Compounds > 14,15-epoxy-5,8,11-eicosatrienoic acid

14,15-epoxy-5,8,11-eicosatrienoic acid and 11,12-epoxy-5,8,14-eicosatrienoic acid

14,15-epoxy-5,8,11-eicosatrienoic acid has been researched along with 11,12-epoxy-5,8,14-eicosatrienoic acid in 92 studies

Research

Studies (92)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (7.61)	18.7374
1990's	29 (31.52)	18.2507
2000's	30 (32.61)	29.6817
2010's	25 (27.17)	24.3611
2020's	1 (1.09)	2.80

Authors

Authors	Studies
Capdevila, JH; Falck, JR; Karara, A; Spady, D; Swift, L; Wei, S	1
Braden, G; Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, J; Shipp, E	1
Carroll, MA; Falck, JR; Garcia, MP; McGiff, JC	1
Amruthesh, SC; Ellis, EF; Police, RJ; Yancey, LM	1
Campbell, WB; Falck, JR; Rosolowsky, M	1
Campbell, WB; Falck, JR; Pfister, SL	1
Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, JA	1
Teien, G; Ulsaker, GA	1
Capdevila, JH; Falck, JR; Guenguerich, FP; Karara, A; Martin, MV; Waxman, DJ	1
Capdevila, JH; Dishman, E; Falck, JR; Jacobson, H; Karara, A	1
Falck, JR; Snyder, GD; Yadagiri, P	1
Blair, IA; Capdevila, JH; Falck, JR; Hammonds, TD	1
Jacoby, M; Levine, SD; Oates, JA; Petty, E; Schlondorff, D	1
Fitzpatrick, F; McGee, J	1
Baze, ME; Ennis, MD; Fitzpatrick, FA; Liggett, WF; McGee, JE; Wynalda, MA	1
Capdevila, J; Falck, JR; Proctor, KG	1
Capdevila, J; Carroll, MA; Falck, JR; McGiff, JC; Schwartzman, M	1
Fang, X; Kaduce, TL; Spector, AA; VanRollins, M	1
Balazy, M; McGiff, JC; Schieber, EB	1
Abraham, N; Escalante, BA; Schwartzman, M; Staudinger, R	1
Evans, RW; Kochanek, PM; Nemoto, EM; Schiding, JK; VanRollins, M	1
Daikh, BE; Koop, DR; Lasker, JM; Raucy, JL	1
Ma, YH; Roman, RJ; Schwartzman, ML	1
Imig, JD; Ortiz de Montellano, PR; Roman, RJ; Sui, Z; Zou, AP	1
Campbell, WB; Rosolowsky, M	1
Bend, JR; Farhangkhoee, P; Karmazyn, M; Mock, T; Moffat, MP; Ward, CA	1
Boyle, JE; Foley, J; Ma, J; Moomaw, CR; Pascual, JM; Steenbergen, C; Tomer, KB; Wu, S; Zeldin, DC	1
Falck, JR; Fleming, JT; Gebremedhin, D; Harder, DR; Jacobs, ER; Roman, RJ; Zou, AP	1
Gimeno, MA; Gonzalez, E; Jawerbaum, A; Novaro, V	1
Chatterjee, P; Fang, X; Kaduce, TL; Spector, AA; VanRollins, M; Weintraub, NL	1
Fedinec, AL; Leffler, CW	1
Baron, A; Bény, JL; Frieden, M	1
Schäfer, W; Schneider, J; Schweer, H; Werner, K; Zahradnik, HP	1
Lee, HC; Lu, T; Shibata, EF; Spector, AA; VanRollins, M; Weintraub, NL	1
Huo, Y; Ley, K; Liao, JK; Node, K; Ruan, X; Spiecker, M; Yang, B; Zeldin, DC	1
Fang, X; Spector, AA; Stoll, LL; Weintraub, NL	1
Bousamra, M; Falck, JR; Harder, DR; Jacobs, ER; Roman, RJ; Townsley, M; Zeldin, DC; Zhu, D	1
Adler, P; Graham, L; Huse, LM; Kroetz, DL; Ma, J; Yu, Z; Zeldin, DC	1
Benech, H; Chéron, G; Colin, I; Cresteil, T; Pruvost, A; Tréluyer, JM	1
Campbell, WB; Nithipatikom, K; Pratt, PF	1
Draper, AJ; Engler, MM; Graham, L; Hammock, BD; Huse, LM; Kroetz, DL; Morisseau, C; Newman, JW; Parker, C; Xu, F; Yu, Z; Zeldin, DC	1
Campbell, WB; Hillard, CJ; Kurian, J; Li, P; Pratt, PF	1
Dai, J; Graham, L; Liao, JK; Node, K; Ruan, XL; Yang, SX; Zeldin, DC	1
Benoit, C; Renaudon, B; Rousseau, E; Salvail, D	1
Dellsperger, KC; Lee, HC; Lu, T; Oltman, CL; VanRollins, M; Zhang, Y	1
Capdevila, JH; Falck, JR; Imig, JD; Wei, S; Zhao, X	1
Harder, D; Medhora, M; Narayanan, J	1
Balazy, M; Falck, JR; Krishna, UM; Reddy, MM; Xia, J	1
Busija, DW; Carrier, GO; Dimitropoulou, C; Han, G; Miller, AW; White, RE	1
Bondlela, M; Campbell, WB; Deeter, C; Falck, JR; Gauthier, KM; Krishna, UM; Reddy, YK	1
Harder, DR; Zhang, C	1
Cox, R; Oleksiak, MF; Parker, C; Qu, W; Stegeman, JJ; Wu, S; Zeldin, DC	1
Callewaert, DM; Campbell, WB; Falck, JR; Gikas, K; Nithipatikom, K; Reddy, M; Sasaki, DM; Yuan, Y	1
Carter, EP; Jacobs, ER; Miyazono, M; Nemenoff, R; Zhu, D	1
Alvarez, DF; Gjerde, EA; Townsley, MI	1
Buerkle, MA; Campbell, WB; Gloe, T; Krötz, F; Nithipatikom, K; Pohl, U; Riexinger, T; Sohn, HY	1
Lee, HC; Ye, D; Zhou, W	1
Liao, JK; Spiecker, M	1
Dunn, BE; Dunn, LK; Falck, JR; Gruenloh, SK; Jacobs, ER; Medhora, M; Reddy, DS	1
Anjaiah, S; Brittin, JJ; Campbell, WB; Capdevila, JH; Cui, L; Falck, JR; Nithipatikom, K; Wei, S	1
Abraham, NG; Bolognesi, M; Di Pascoli, M; Gatta, A; McGiff, JC; Sacerdoti, D; Schwartzman, ML	1
Cao, S; Lee, HC; Lu, T; Shah, VH; Wang, XL	1
Chen, RJ; Cowart, LA; Jiang, JG; Wang, DW; Wang, JN; Wang, Y; Xia, Y; Xiao, B; Xiao, X; Yang, S	1
Falck, JR; Gross, GJ; Hsu, A; Nithipatikom, K	1
Campbell, WB; Falck, JR; Gauthier, KM; Gross, GJ; Hammock, BD; Moore, J; Nithipatikom, K	1
Fu, XN; Jiang, JG; Shen, GF; Wang, DW	1
Hammock, B; King, JA; Morisseau, C; Townsley, MI	1
Baker, JE; Falck, JR; Gross, GJ; Hsu, A; Nithipatikom, K; Wu, HE	1
Ilatovskaya, DV; Levchenko, V; Mattson, DL; Pavlov, TS; Roman, RJ; Staruschenko, A	1
Chen, Z; Jiang, J; Li, Q; Liu, F; Shao, J; Wang, H; Zhu, X; Zou, P	1
Barker, JH; Fleming, I; Frank, J; Jakob, H; Marzi, I; Neumayer, T; Sander, AL; Sommer, K	1
Cracowski, C; Cracowski, JL; Gaillard-Bigot, F; Millet, C; Roustit, M; Sors, C	1
Chen, C; Duan, Q; Edin, ML; Ni, L; Wang, DW; Wang, X; Yang, L; Zeldin, DC	1
Althurwi, HN; El-Kadi, AO; Elshenawy, OH	1
Diani-Moore, S; Gross, SS; Ma, Y; Rifkind, AB	1
Abdelrady, M; Amara, IE; El-Kadi, AO; Elshenawy, OH	1
Jiang, JX; Lin, XX; Liu, YN; Shen, HJ; Sun, YH; Xie, QM; Yan, XF; Zhang, SJ	1
Dong, XW; Jiang, JX; Ma, WJ; Sun, YH; Xie, QM; Zhou, JY	1
Imig, JD	1
Barrett, FG; Binder, V; Bowman, TV; Daley, GQ; Heffner, GC; Lahvic, JL; Li, P; McKinney-Freeman, S; Panigrahy, D; Pugach, EK; Riley, EB; Schlaeger, TM; Tamplin, OJ; Zeldin, DC; Zon, LI	1
Froogh, G; Huang, A; Kandhi, S; Luo, M; Qin, J; Sun, D; Wolin, MS	1
Fleming, I	1
Červenka, L; Falck, JR; Imig, JD; Kopkan, L; Reddy, RN; Sadowski, J; Sporková, A	1
Funk, DJ; Kopka, K; Schmeiser, HH; Sorg, BL	1
Dong, L; Duan, JX; Guan, CX; Hammock, BD; Jiang, JX; Lee, KSS; Li, P; Liu, T; Liu, YP; Sun, GY; Zhang, J; Zhou, Y	1
Eliasson, E; Hayakawa, T; Inotsume, N; Kato, Y; Mukai, Y; Rane, A; Senda, A; Toda, T	1
Barnych, B; Cajka, T; Hammock, BD; Lee, KSS; Morisseau, C; Panigrahy, D; Rand, AA	1
Arand, M; Falck, JR; Marowsky, A; Mule, NK; Orjuela Leon, AC	1
Aliwarga, T; Gharib, SA; Lemaitre, RN; Raccor, BS; Sotoodehnia, N; Totah, RA; Xu, L	1
Chan, ECY; Hagen, T; Karkhanis, A; Leow, JWH	1
Abraham, NG; Bellner, L; Bradbury, JA; Cao, J; Liu, L; Puri, N; Raffaele, M; Schragenheim, J; Singh, SP; Vanella, L; Zeldin, DC	1
Imig, JD; Jankiewicz, WK; Khan, AH	1

Reviews

4 review(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 11,12-epoxy-5,8,14-eicosatrienoic acid

Article	Year
Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids. Trends in cardiovascular medicine, 2001, Volume: 11, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain Chemistry; Cerebrovascular Circulation; Endothelium, Vascular; Humans; Microcirculation; Muscle, Smooth, Vascular; Vasodilation	2001
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. Archives of biochemistry and biophysics, 2005, Jan-15, Volume: 433, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Movement; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Eicosanoids; Fibrinolysis; Humans; Inflammation; Isoenzymes; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Cardiac; NF-kappa B; Oxygenases; Protective Agents; Stereoisomerism; Vasodilation	2005
Epoxyeicosatrienoic acids, hypertension, and kidney injury. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antihypertensive Agents; Disease Models, Animal; Disease Progression; Endothelium, Vascular; Fatty Acids; Humans; Hypertension; Kidney Diseases; Mice; Rats	2015
The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling. Vascular pharmacology, 2016, Volume: 86 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Factors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Docosahexaenoic Acids; Eicosapentaenoic Acid; Endothelium, Vascular; Epoxide Hydrolases; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Humans; Signal Transduction	2016

Trials

1 trial(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 11,12-epoxy-5,8,14-eicosatrienoic acid

Article	Year
Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. Journal of applied physiology (Bethesda, Md. : 1985), 2013, Jan-15, Volume: 114, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Adult; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Fluconazole; Humans; Hyperemia; Lidocaine; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Regional Blood Flow; Sensory Receptor Cells; Skin; Skin Diseases	2013

Article

Year

Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans.

Journal of applied physiology (Bethesda, Md. : 1985), 2013, Jan-15, Volume: 114, Issue:2

Topics: 8,11,14-Eicosatrienoic Acid; Adult; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Fluconazole; Humans; Hyperemia; Lidocaine; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Regional Blood Flow; Sensory Receptor Cells; Skin; Skin Diseases

2013

Other Studies

87 other study(ies) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 11,12-epoxy-5,8,14-eicosatrienoic acid

Article	Year
Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. Biochemical and biophysical research communications, 1992, Feb-14, Volume: 182, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Isomerism; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Oxygenases; Rats; Rats, Inbred Strains	1992
Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease. Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Angina, Unstable; Angioplasty, Balloon, Coronary; Arachidonic Acid; Arachidonic Acids; Colforsin; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Humans; Oxygenases; Platelet Activation; Pre-Eclampsia; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thrombin	1991
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Eicosanoids; Free Radicals; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Renal Circulation; Vascular Resistance	1992
Brain synthesis and cerebrovascular action of cytochrome P-450/monooxygenase metabolites of arachidonic acid. Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Cerebrovascular Circulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Free Radicals; Indomethacin; Mice; Oxygen; Oxygenases; Prostaglandins; Vasodilation	1991
Synthesis and biological activity of epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells. Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Cells, Cultured; Coronary Vessels; Dogs; Endothelium, Vascular; Epoprostenol; Hydroxyeicosatetraenoic Acids; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Vasodilation	1991
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 2 Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acids; Carbon Radioisotopes; Cholesterol, Dietary; Clotrimazole; Diet, Atherogenic; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Kinetics; Masoprocol; Metyrapone; Muscle, Smooth, Vascular; Rabbits; Reference Values; Stereoisomerism	1991
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:15 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Dogs; Fatty Acids, Unsaturated; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Radioisotope Dilution Technique; Reference Values; Tritium	1990
Gas chromatographic-mass spectrometric identification of four triene monoepoxides of arachidonic acid in human plasma. The Analyst, 1990, Volume: 115, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Aluminum; Aluminum Compounds; Deuterium; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Humans; Lithium; Lithium Compounds; Molecular Structure; Oxidation-Reduction	1990
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. The Journal of biological chemistry, 1990, Jul-05, Volume: 265, Issue:19 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism; Substrate Specificity	1990
Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. FEBS letters, 1990, Jul-30, Volume: 268, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Humans; Kidney Cortex; Male; Mass Spectrometry; Oxygenases; Stereoisomerism	1990
Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs. The American journal of physiology, 1989, Volume: 256, Issue:2 Pt 1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cells, Cultured; Fatty Acids, Unsaturated; Growth Hormone; Growth Hormone-Releasing Hormone; Indomethacin; Kinetics; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Somatostatin	1989
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. Analytical biochemistry, 1989, Nov-01, Volume: 182, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Chromatography, High Pressure Liquid; Fatty Acids, Unsaturated; Stereoisomerism	1989
Epoxygenase metabolites of arachidonic acid inhibit vasopressin response in toad bladder. The American journal of physiology, 1987, Volume: 253, Issue:3 Pt 2 Topics: 8,11,14-Eicosatrienoic Acid; Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Bufo marinus; Colforsin; Cyclic AMP; Epithelium; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Urinary Bladder; Vasopressins; Water-Electrolyte Balance	1987
Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes. The Journal of biological chemistry, 1985, Oct-15, Volume: 260, Issue:23 Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acids; Chromatography; Cytosol; Electrophoresis, Polyacrylamide Gel; Epoxide Hydrolases; Erythrocytes; Humans; Isoelectric Point; Leukotriene A4; Leukotriene B4; Molecular Weight; Stilbenes; Substrate Specificity	1985
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry. The Journal of biological chemistry, 1986, Nov-15, Volume: 261, Issue:32 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Humans; Kinetics; Male; Platelet Aggregation; Seminal Vesicles; Sheep; Structure-Activity Relationship	1986
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase. Circulation research, 1987, Volume: 60, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Intestinal Mucosa; Intestines; Male; Rats; Regional Blood Flow; Structure-Activity Relationship; Vasodilation	1987
Vasoactivity of arachidonic acid epoxides. European journal of pharmacology, 1987, Jun-19, Volume: 138, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Rats; Vasodilator Agents	1987
Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells. Journal of lipid research, 1995, Volume: 36, Issue:6 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Kinetics; Muscle, Smooth, Vascular; Phospholipids; Swine; Tritium	1995
Identification of arachidonate epoxides in human platelets. Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23 Topics: 8,11,14-Eicosatrienoic Acid; Blood Platelets; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Phospholipids	1995
Amiloride-sensitive ion transport inhibition by epoxyeicosatrienoic acids in renal epithelial cells. Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23 Topics: 8,11,14-Eicosatrienoic Acid; Amiloride; Animals; Biological Transport; Cell Line; Epithelium; Kidney; Rubidium; Rubidium Radioisotopes; Structure-Activity Relationship	1995
Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo. Biochimica et biophysica acta, 1995, Jun-06, Volume: 1256, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Infusions, Intravenous; Male; Rats; Rats, Wistar	1995
Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Male; Microsomes, Liver; Molecular Sequence Data; Rabbits; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1994
Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Prostaglandins; Rats; Rats, Inbred Strains; Sodium Chloride	1994
Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arterioles; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Kidney Cortex; Miconazole; Microsomes; Muscle, Smooth, Vascular; Oxazines; Perfusion; Rats; Rats, Sprague-Dawley; Renal Circulation	1994
Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. The American journal of physiology, 1993, Volume: 264, Issue:2 Pt 2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arteries; Cattle; Coronary Vessels; Epoprostenol; Vasodilation	1993
Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Heart Rate; Heart Ventricles; Male; Myocardium; Reperfusion Injury; Time Factors	1993
CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. Molecular pharmacology, 1996, Volume: 50, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blotting, Northern; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; Immunohistochemistry; Isoenzymes; Lung; Macrophages, Alveolar; Muscle, Smooth, Vascular; Rats	1996
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. The American journal of physiology, 1996, Volume: 270, Issue:5 Pt 2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Electric Conductivity; Muscle Tonus; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Renal Artery; Stereoisomerism; Vasoconstriction	1996
Influence of epoxyeicosatrienoic acids on uterine function. Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Clotrimazole; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Estradiol; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Ovariectomy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Uterine Contraction	1997
Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids. Circulation research, 1997, Volume: 81, Issue:2 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Bradykinin; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane A2; Vasoconstrictor Agents; Vasodilation	1997
Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids. The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2 Topics: 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arterioles; Carbon Dioxide; Cyclic AMP; Dose-Response Relationship, Drug; Iloprost; Indomethacin; Muscle, Smooth, Vascular; Nitroprusside; Pia Mater; Structure-Activity Relationship; Swine; Vasodilation; Vasodilator Agents	1997
Epoxyeicosatrienoic acids activate a high-conductance, Ca(2+)-dependent K + channel on pig coronary artery endothelial cells. The Journal of physiology, 1997, Nov-01, Volume: 504 ( Pt 3) Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Membrane Potentials; Potassium Channels; Swine	1997
Formation of cytochrome P450 metabolites of arachidonic acid by human placenta. Advances in experimental medicine and biology, 1997, Volume: 433 Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acids; Calcimycin; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxyeicosatetraenoic Acids; Organ Culture Techniques; Placenta; Pregnancy; Reference Values	1997
Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes. The Journal of physiology, 1999, Aug-15, Volume: 519 Pt 1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arachidonic Acid; Cells, Cultured; Heart; Heart Ventricles; Membrane Potentials; Myocardium; Rats; Rats, Sprague-Dawley; Sodium Channels; Structure-Activity Relationship	1999
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science (New York, N.Y.), 1999, Aug-20, Volume: 285, Issue:5431 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Arteries; Cattle; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Coronary Vessels; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; I-kappa B Kinase; I-kappa B Proteins; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Oxygenases; Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1	1999
Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:6 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Chelating Agents; Coronary Vessels; Dose-Response Relationship, Drug; In Vitro Techniques; Intracellular Fluid; Muscle Contraction; Muscle, Smooth, Vascular; Structure-Activity Relationship; Swine; Vasoconstrictor Agents; Vasodilator Agents	1999
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Dogs; In Vitro Techniques; Male; Pressure; Pulmonary Artery; Rabbits; Vasoconstriction; Vasoconstrictor Agents; Vasomotor System	2000
Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. Molecular pharmacology, 2000, Volume: 57, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Hypertension; Kidney; Liver; Male; Oxygenases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger	2000
Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome. Pediatric research, 2000, Volume: 47, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Adult; Age Factors; Arachidonic Acid; Arachidonic Acids; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Infant; Isoenzymes; Liver; Microsomes, Liver; NADP; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sudden Infant Death; Up-Regulation	2000
Determination of EETs using microbore liquid chromatography with fluorescence detection. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bradykinin; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Coronary Vessels; Endothelium, Vascular; Methacholine Chloride; Microchemistry; Spectrometry, Fluorescence	2000
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circulation research, 2000, Nov-24, Volume: 87, Issue:11 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Blood Pressure; Cytosol; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Epoxy Compounds; Hydrolysis; Hypertension; Kidney Cortex; Male; Microsomes; Microsomes, Liver; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Species Specificity; Urea	2000
Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:3 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Benzopyrans; Biological Factors; Bradykinin; Cardiotonic Agents; Cattle; Coronary Vessels; Dihydropyridines; Electrophysiology; Endothelium, Vascular; Membrane Potentials; Muscle, Smooth, Vascular; Nitroprusside; Ouabain; Peptides; Potassium; Potassium Channels; Tritium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2001
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Atropine Derivatives; Cattle; Cells, Cultured; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Oxygenases; Polymerase Chain Reaction; Proadifen; Promoter Regions, Genetic; Saphenous Vein; Tissue Plasminogen Activator; Transcription, Genetic; Transfection	2001
EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization. American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Biological Factors; Bronchoconstriction; Cattle; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Muscarinic Agonists; Muscle, Smooth; Nitric Oxide Synthase; Peptides; Potassium Channels; Potassium Channels, Calcium-Activated; Rabbits; Trachea	2001
EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterioles; Calcium Channel Agonists; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Microcirculation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Stereoisomerism; Swine; Vasodilation; Vasodilator Agents	2001
Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid. Journal of hypertension, 2001, Volume: 19, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II; Animals; Arterioles; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Drug Synergism; Hypertension; Kidney Cortex; Male; Microcirculation; Microsomes; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides; Vasoconstriction	2001
Stereospecific synthesis of trans-arachidonic acids. Bioorganic & medicinal chemistry letters, 2001, Sep-17, Volume: 11, Issue:18 Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Biochemistry; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Stereoisomerism	2001
Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:4 Topics: 8,11,14-Eicosatrienoic Acid; Animals; In Vitro Techniques; Insulin Resistance; Male; Mesenteric Arteries; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reference Values; Vasodilation; Vasodilator Agents	2001
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circulation research, 2002, May-17, Volume: 90, Issue:9 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cattle; Coronary Vessels; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium, Vascular; Iloprost; In Vitro Techniques; Kidney Cortex; Male; Microsomes; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasoconstriction; Vasoconstrictor Agents; Vasodilation	2002
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid. Stroke, 2002, Volume: 33, Issue:12 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain; Capillaries; Cell Differentiation; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Intercellular Signaling Peptides and Proteins; Lymphokines; Mitosis; Neovascularization, Physiologic; Rats; Thymidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2002
Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. Archives of biochemistry and biophysics, 2003, Mar-15, Volume: 411, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Benzphetamine; Cloning, Molecular; Conserved Sequence; Cytochrome P-450 Enzyme System; Fasting; Fundulidae; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Male; Molecular Sequence Data; Multigene Family; Organ Specificity; Phylogeny; Rats; Rats, Inbred F344; RNA, Messenger; Sequence Alignment; Tetradecanoylphorbol Acetate; Vertebrates	2003
Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs. Advances in experimental medicine and biology, 2002, Volume: 507 Topics: 8,11,14-Eicosatrienoic Acid; Antibodies; Arachidonic Acids; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Hydroxylation; Isomerism; Sensitivity and Specificity	2002
Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis. Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:7 Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Arachidonic Acid; Bile Ducts; Blotting, Western; Body Weight; Cell Division; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Hemodynamics; Kidney; Liver Cirrhosis; Nitric Oxide; Perfusion; Phospholipases A; Protein Isoforms; Rats; Time Factors	2003
Role of EETs in regulation of endothelial permeability in rat lung. American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Capillary Permeability; Endothelium, Vascular; Lung; Male; Pulmonary Circulation; Rats; Rats, Inbred Strains; Vasodilator Agents	2004
Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Apamin; Aryl Hydrocarbon Hydroxylases; Biological Factors; Blood Platelets; Cells, Cultured; Charybdotoxin; Cytochrome P-450 CYP2C9; Endothelial Cells; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Ion Channels; Membrane Potentials; Peptides; Platelet Adhesiveness; Platelet Aggregation; Potassium Channels; Recombinant Fusion Proteins; Transfection; Umbilical Veins	2004
Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Potassium Channels; Rats; Vasodilation; Vasodilator Agents	2005
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, 2005, Volume: 285, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Capillaries; Chick Embryo; Chorioallantoic Membrane; Culture Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperemia; Neovascularization, Physiologic; Nitric Oxide Donors; Time Factors; Vasodilator Agents; Vitelline Membrane	2005
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. Analytical biochemistry, 2006, May-01, Volume: 352, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Oxygenases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasodilator Agents	2006
Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:4 Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Carbon Monoxide; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); Male; Mesenteric Arteries; Mesoporphyrins; Organometallic Compounds; Oxadiazoles; Peptides; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents	2006
Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids. Biochimica et biophysica acta, 2006, Volume: 1761, Issue:9 Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Line; Glutathione Transferase; Humans; Ion Channel Gating; Mice; Potassium Channels, Inwardly Rectifying; Protein Binding; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Receptors	2006
Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. Prostaglandins & other lipid mediators, 2007, Volume: 82, Issue:1-4 Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Aorta, Thoracic; Apigenin; Cattle; Cells, Cultured; Chromones; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epoxy Compounds; Flavonoids; Inositol; Male; MAP Kinase Signaling System; Morpholines; Nitric Oxide Synthase Type III; Oxygenases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphothreonine; Proto-Oncogene Proteins c-akt; Rats; Serine	2007
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. Journal of molecular and cellular cardiology, 2007, Volume: 42, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Male; Myocardial Infarction; Potassium Channels; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tiopronin	2007
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:6 Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Blood Pressure; Cardiovascular Agents; Coronary Circulation; Diazoxide; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoxide Hydrolases; Female; Heart Rate; Lauric Acids; Male; Mitochondria, Heart; Myocardial Infarction; Myocardium; Potassium Channels	2008
[Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells]. Ai zheng = Aizheng = Chinese journal of cancer, 2008, Volume: 27, Issue:11 Topics: 8,11,14-Eicosatrienoic Acid; Apigenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Flavonoids; Humans; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction	2008
Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury. Microcirculation (New York, N.Y. : 1994), 2010, Volume: 17, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Capillary Permeability; Cell Adhesion Molecules; Endothelium, Vascular; In Vitro Techniques; Lung; Lung Injury; Rats; Reperfusion Injury; TRPV Cation Channels; Vascular Cell Adhesion Molecule-1	2010
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:6 Topics: 8,11,14-Eicosatrienoic Acid; Analgesics, Opioid; Animals; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gi-Go; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin	2010
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). American journal of physiology. Renal physiology, 2011, Volume: 301, Issue:3 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme System; Diclofenac; Epithelial Sodium Channels; Female; Ibuprofen; Kidney Tubules, Collecting; Mice; Models, Animal; Ovary; Patch-Clamp Techniques; Transfection	2011
P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2011, Volume: 31, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Bone Marrow Neoplasms; Cell Line; Cell Line, Tumor; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelial Cells; Fatty Acids, Unsaturated; Humans; Mice; Mice, Inbred C57BL; Multiple Myeloma; Neovascularization, Pathologic	2011
Soluble epoxide hydrolase disruption as therapeutic target for wound healing. The Journal of surgical research, 2013, Jun-15, Volume: 182, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Epoxide Hydrolases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Re-Epithelialization; Tumor Necrosis Factor-alpha; Wound Healing	2013
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. Molecular pharmacology, 2014, Volume: 85, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Apoptosis; Calcium; Cardiomegaly; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum Stress; Heart Failure; Humans; In Vitro Techniques; Major Histocompatibility Complex; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Rats; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases	2014
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiomegaly; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fenofibrate; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Isoproterenol; Male; Rats; Rats, Sprague-Dawley	2014
Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolas Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:2 Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Chick Embryo; Enzyme Inhibitors; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Heart; Hydroxyeicosatetraenoic Acids; Lauric Acids; Liver; Polychlorinated Dibenzodioxins; RNA, Messenger	2014
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. Toxicology letters, 2014, Apr-07, Volume: 226, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Atrial Natriuretic Factor; Biomarkers; Cardiomegaly; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Heart; Injections, Intraperitoneal; Isoenzymes; Male; Mercuric Chloride; Mice; Mice, Inbred C57BL; Myocardium; Natriuretic Peptide, Brain; RNA, Messenger	2014
EETs alleviate ox-LDL-induced inflammation by inhibiting LOX-1 receptor expression in rat pulmonary arterial endothelial cells. European journal of pharmacology, 2014, Mar-15, Volume: 727 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Inflammation; Inflammation Mediators; Lipoproteins, LDL; Male; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; RNA, Messenger; Scavenger Receptors, Class E; Signal Transduction	2014
Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells. Prostaglandins, leukotrienes, and essential fatty acids, 2015, Volume: 94 Topics: 8,11,14-Eicosatrienoic Acid; Anti-Inflammatory Agents; Bronchi; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epithelial Cells; Gene Expression Regulation; Humans; Interleukin-8; MAP Kinase Signaling System; Smoking; Vasodilator Agents	2015
Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature, 2015, Jul-23, Volume: 523, Issue:7561 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Line; Cell Movement; Core Binding Factor Alpha 2 Subunit; Female; Gene Expression Regulation; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Human Umbilical Vein Endothelial Cells; Humans; Kidney; Male; Mice; Phosphatidylinositol 3-Kinases; Transcription Factor AP-1; Transcription, Genetic; Zebrafish	2015
EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice. American journal of hypertension, 2016, Volume: 29, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterial Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Male; Mice, Inbred C57BL; Pulmonary Artery; Time Factors; Ventricular Function, Right; Ventricular Pressure	2016
Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids. The American journal of the medical sciences, 2016, Volume: 351, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Hypertension, Renovascular; Kidney; Male; Rats; Rats, Sprague-Dawley; Renal Artery; Vasodilation; Vasodilator Agents	2016
Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro. Prostaglandins & other lipid mediators, 2016, Volume: 123 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Adducts; Hydrogen-Ion Concentration; Kinetics; Phosphorus Radioisotopes; Solutions; Stereoisomerism	2016
Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice. Shock (Augusta, Ga.), 2017, Volume: 47, Issue:5 Topics: 8,11,14-Eicosatrienoic Acid; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Epoxide Hydrolases; Interleukin-1beta; Lipopolysaccharides; Mice; NF-kappa B; Pneumonia; RAW 264.7 Cells; Tumor Necrosis Factor-alpha	2017
Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes. Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:4 Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II Type 1 Receptor Blockers; Arachidonic Acid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Kinetics; Liver; Microsomes, Liver; Recombinant Proteins	2017
Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proceedings of the National Academy of Sciences of the United States of America, 2017, 04-25, Volume: 114, Issue:17 Topics: 8,11,14-Eicosatrienoic Acid; Angiogenesis Inducing Agents; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Humans	2017
11,12 -Epoxyeicosatrienoic acid (11,12 EET) reduces excitability and excitatory transmission in the hippocampus. Neuropharmacology, 2017, Sep-01, Volume: 123 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anticonvulsants; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Glutamic Acid; Hippocampus; Immunohistochemistry; Male; Mice, Inbred C57BL; Neurotransmitter Agents; Patch-Clamp Techniques; Presynaptic Terminals; Pyramidal Cells; Synaptic Transmission; Tissue Culture Techniques	2017
Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo. Free radical biology & medicine, 2017, Volume: 112 Topics: 8,11,14-Eicosatrienoic Acid; Aging; Animals; Arachidonic Acid; Benzene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erythrocyte Membrane; Female; Humans; Liposomes; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidation-Reduction; Peroxides; Stereoisomerism; Tandem Mass Spectrometry	2017
Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids. Toxicological sciences : an official journal of the Society of Toxicology, 2018, 05-01, Volume: 163, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Anti-Arrhythmia Agents; Cardiotonic Agents; Cell Line; Cell Survival; Dronedarone; Humans; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac	2018
Ablation of soluble epoxide hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo. Prostaglandins & other lipid mediators, 2018, Volume: 138 Topics: 3T3-L1 Cells; 8,11,14-Eicosatrienoic Acid; Adipocytes; Adiponectin; Adipose Tissue, Beige; Adipose Tissue, White; Animals; Cells, Cultured; Epoxide Hydrolases; Gene Expression; Heme Oxygenase-1; Humans; Mesenchymal Stem Cells; Mice; Mice, Knockout; Mitochondria; RNA Interference; Solubility; Vasodilator Agents	2018
Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture. Hypertension (Dallas, Tex. : 1979), 2020, Volume: 76, Issue:1 Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiovascular Diseases; Cytochrome P-450 Enzyme System; Disease Models, Animal; Epoxide Hydrolases; Forecasting; Humans; Hypertension; Kidney; Kidney Diseases; Mice; Natriuresis; Potassium; Rats; Rats, Inbred Dahl; Sodium Chloride; Sodium Chloride, Dietary; Vasodilation; Water-Electrolyte Balance; Water-Electrolyte Imbalance	2020