10-propargyl-10-deazaaminopterin has been researched along with pemetrexed in 7 studies
| Studies (10-propargyl-10-deazaaminopterin) | Trials (10-propargyl-10-deazaaminopterin) | Recent Studies (post-2010) (10-propargyl-10-deazaaminopterin) | Studies (pemetrexed) | Trials (pemetrexed) | Recent Studies (post-2010) (pemetrexed) |
|---|---|---|---|---|---|
| 119 | 21 | 85 | 2,469 | 657 | 1,695 |
| Protein | Taxonomy | 10-propargyl-10-deazaaminopterin (IC50) | pemetrexed (IC50) |
|---|---|---|---|
| Thymidylate synthase | Escherichia coli | 1.1 | |
| Dihydrofolate reductase | Homo sapiens (human) | 4.0309 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 2.3 | |
| Thymidylate synthase | Homo sapiens (human) | 8.1787 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 2.3 | |
| Folate receptor beta | Homo sapiens (human) | 0.2585 | |
| Folate receptor alpha | Homo sapiens (human) | 0.2417 | |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | 0.0342 | |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | 0.07 | |
| Reduced folate transporter | Homo sapiens (human) | 0.0928 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 1.655 | |
| Proton-coupled folate transporter | Homo sapiens (human) | 0.0229 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Cherian, C; Gangjee, A; Hou, Z; Matherly, LH; Mitchell-Ryan, S; Orr, S; Raghavan, S; Wang, Y | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Gangjee, A; George, C; Hou, Z; Karim, MA; Kushner, J; Matherly, LH; O'Connor, C; Polin, L; Ravindra, M; Wallace-Povirk, A; White, K; Wilson, MR | 1 |
| Chen, XB; Wang, S; Wang, SQ; Yu, B; Yuan, XH; Zhao, W | 1 |
| Campos, D; Diaz, A; Izbicka, E; Saunders, M; Steffen, R; Streeper, R; Wick, M | 1 |
| Bertino, JR; Farooqi, IN; Kathari, YK; Tedeschi, PM | 1 |
2 review(s) available for 10-propargyl-10-deazaaminopterin and pemetrexed
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application.
Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Humans; Molecular Structure; Neoplasms; Pyrimidines; United States; United States Food and Drug Administration | 2021 |
5 other study(ies) available for 10-propargyl-10-deazaaminopterin and pemetrexed
| Article | Year |
|---|---|
Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
Topics: Animals; Cell Proliferation; Cells, Cultured; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Models, Molecular; Molecular Structure; Purine Nucleotides; Pyrimidines; Pyrroles; Structure-Activity Relationship | 2013 |
Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; CHO Cells; Cricetulus; Folate Receptor 1; Folate Receptor 2; Folic Acid Antagonists; Heterografts; Humans; Mice; Mice, SCID; Proton-Coupled Folate Transporter; Purine Nucleotides; Pyrimidines; Pyrroles | 2018 |
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
Topics: Aminopterin; Cell Line, Tumor; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Kinetics; Methotrexate; Neoplasms; Pemetrexed; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Xenograft Model Antitumor Assays | 2009 |
StatBite: FDA oncology drug product approvals in 2009.
Topics: Administration, Oral; Aminopterin; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Cetuximab; Depsipeptides; Drug Approval; Everolimus; Ferrosoferric Oxide; Glutamates; Guanine; Humans; Indazoles; Injections; Panitumumab; Pemetrexed; Pyrimidines; Sirolimus; Sulfonamides; United States; United States Food and Drug Administration | 2010 |
Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts.
Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Folic Acid Antagonists; Glutamates; Guanine; Humans; Leucovorin; Mesothelioma; Methotrexate; Mice, Nude; Pemetrexed; Time Factors; Tumor Burden; Vitamin B Complex; Xenograft Model Antitumor Assays | 2014 |