Compounds > 10-propargyl-10-deazaaminopterin
Page last updated: 2024-09-04

10-propargyl-10-deazaaminopterin and guanine

10-propargyl-10-deazaaminopterin has been researched along with guanine in 3 studies

Compound Research Comparison

Studies
(10-propargyl-10-deazaaminopterin)		Trials
(10-propargyl-10-deazaaminopterin)		Recent Studies (post-2010)
(10-propargyl-10-deazaaminopterin)		Studies
(guanine)		Trials
(guanine)		Recent Studies (post-2010) (guanine)
119218516,2788224,809

Protein Interaction Comparison

ProteinTaxonomy10-propargyl-10-deazaaminopterin (IC50)guanine (IC50)
Purine nucleoside phosphorylaseHomo sapiens (human)5

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Campos, D; Diaz, A; Izbicka, E; Saunders, M; Steffen, R; Streeper, R; Wick, M1
Bertino, JR; Farooqi, IN; Kathari, YK; Tedeschi, PM1

Other Studies

3 other study(ies) available for 10-propargyl-10-deazaaminopterin and guanine

ArticleYear
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
    Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:5

    Topics: Aminopterin; Cell Line, Tumor; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Kinetics; Methotrexate; Neoplasms; Pemetrexed; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Xenograft Model Antitumor Assays

2009
StatBite: FDA oncology drug product approvals in 2009.
    Journal of the National Cancer Institute, 2010, Feb-24, Volume: 102, Issue:4

    Topics: Administration, Oral; Aminopterin; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Cetuximab; Depsipeptides; Drug Approval; Everolimus; Ferrosoferric Oxide; Glutamates; Guanine; Humans; Indazoles; Injections; Panitumumab; Pemetrexed; Pyrimidines; Sirolimus; Sulfonamides; United States; United States Food and Drug Administration

2010
Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts.
    Cancer chemotherapy and pharmacology, 2014, Volume: 74, Issue:5

    Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Folic Acid Antagonists; Glutamates; Guanine; Humans; Leucovorin; Mesothelioma; Methotrexate; Mice, Nude; Pemetrexed; Time Factors; Tumor Burden; Vitamin B Complex; Xenograft Model Antitumor Assays

2014