10-propargyl-10-deazaaminopterin and folic acid

10-propargyl-10-deazaaminopterin has been researched along with folic acid in 6 studies

Compound Research Comparison

Studies (10-propargyl-10-deazaaminopterin)	Trials (10-propargyl-10-deazaaminopterin)	Recent Studies (post-2010) (10-propargyl-10-deazaaminopterin)	Studies (folic acid)	Trials (folic acid)	Recent Studies (post-2010) (folic acid)
119	21	85	30,001	1,945	10,195

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	5 (83.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cherian, C; Gangjee, A; Hou, Z; Matherly, LH; Mitchell-Ryan, S; Orr, S; Raghavan, S; Wang, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Berthelot, CN; Duvic, M; Jones, D; Leitenberger, JJ; McLaughlin, P; Polder, KD; Pro, B	1
Azzoli, CG; Dunne, M; Ginsberg, M; Huntington, M; James, L; Kris, MG; Krug, LM; May, J; Miller, V; Patel, JD; Saunders, M; Sirotnak, FM; Subzwari, S; Tyson, L	1
Hou, Z; Matherly, LH; Wilson, MR	1
Apollo, A; Cox, L; Fury, MG; Haque, S; Ho, AL; Lipson, BL; Lyo, JK; Pfister, DG; Sales, R; Seetharamu, N; Sherman, EJ; Sima, CS; Xiao, H	1

Reviews

2 review(s) available for 10-propargyl-10-deazaaminopterin and folic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:4 Topics: Aminopterin; Animals; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein	2014

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.

Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:4

Topics: Aminopterin; Animals; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein

2014

Trials

2 trial(s) available for 10-propargyl-10-deazaaminopterin and folic acid

Article	Year
Pralatrexate with vitamin supplementation in patients with previously treated, advanced non-small cell lung cancer: safety and efficacy in a phase 1 trial. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2011, Volume: 6, Issue:11 Topics: Adenocarcinoma; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Prognosis; Tissue Distribution; Vitamin B 12; Vitamin B Complex	2011
A phase II study of pralatrexate with vitamin B12 and folic acid supplementation for previously treated recurrent and/or metastatic head and neck squamous cell cancer. Investigational new drugs, 2014, Volume: 32, Issue:3 Topics: Adult; Aged; Aminopterin; Carcinoma, Squamous Cell; Disease Progression; Female; Folic Acid; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Squamous Cell Carcinoma of Head and Neck; Vitamin B 12; Vitamin B Complex; Young Adult	2014

Article

Year

Pralatrexate with vitamin supplementation in patients with previously treated, advanced non-small cell lung cancer: safety and efficacy in a phase 1 trial.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2011, Volume: 6, Issue:11

Topics: Adenocarcinoma; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Prognosis; Tissue Distribution; Vitamin B 12; Vitamin B Complex

2011

A phase II study of pralatrexate with vitamin B12 and folic acid supplementation for previously treated recurrent and/or metastatic head and neck squamous cell cancer.

Investigational new drugs, 2014, Volume: 32, Issue:3

Topics: Adult; Aged; Aminopterin; Carcinoma, Squamous Cell; Disease Progression; Female; Folic Acid; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Squamous Cell Carcinoma of Head and Neck; Vitamin B 12; Vitamin B Complex; Young Adult

2014

Other Studies

2 other study(ies) available for 10-propargyl-10-deazaaminopterin and folic acid

Article	Year
Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis. Journal of medicinal chemistry, 2013, Nov-14, Volume: 56, Issue:21 Topics: Animals; Cell Proliferation; Cells, Cultured; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Models, Molecular; Molecular Structure; Purine Nucleotides; Pyrimidines; Pyrroles; Structure-Activity Relationship	2013
CD4+ CD56+ hematodermic/plasmacytoid dendritic cell tumor with response to pralatrexate. Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:3 Topics: Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; CD4 Antigens; CD56 Antigen; Cyclophosphamide; Dendritic Cells; Doxorubicin; Drug Therapy, Combination; Female; Folic Acid; Humans; Killer Cells, Natural; Lymphoma, T-Cell; Neoplasm Recurrence, Local; Positron-Emission Tomography; Prednisone; Skin Neoplasms; Treatment Outcome; Vincristine; Vitamin B 12	2008

Article

Year

Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.

Journal of medicinal chemistry, 2013, Nov-14, Volume: 56, Issue:21

Topics: Animals; Cell Proliferation; Cells, Cultured; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Models, Molecular; Molecular Structure; Purine Nucleotides; Pyrimidines; Pyrroles; Structure-Activity Relationship

2013

CD4+ CD56+ hematodermic/plasmacytoid dendritic cell tumor with response to pralatrexate.

Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:3

Topics: Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; CD4 Antigens; CD56 Antigen; Cyclophosphamide; Dendritic Cells; Doxorubicin; Drug Therapy, Combination; Female; Folic Acid; Humans; Killer Cells, Natural; Lymphoma, T-Cell; Neoplasm Recurrence, Local; Positron-Emission Tomography; Prednisone; Skin Neoplasms; Treatment Outcome; Vincristine; Vitamin B 12

2008