10-propargyl-10-deazaaminopterin and fluorouracil

10-propargyl-10-deazaaminopterin has been researched along with fluorouracil in 2 studies

Compound Research Comparison

Studies (10-propargyl-10-deazaaminopterin)	Trials (10-propargyl-10-deazaaminopterin)	Recent Studies (post-2010) (10-propargyl-10-deazaaminopterin)	Studies (fluorouracil)	Trials (fluorouracil)	Recent Studies (post-2010) (fluorouracil)
119	21	85	45,562	9,307	14,663

Protein Interaction Comparison

Protein	Taxonomy	fluorouracil (IC50)
Epidermal growth factor receptor	Homo sapiens (human)	0.32
Thymidylate synthase	Mus musculus (house mouse)	1.58
Aromatase	Homo sapiens (human)	0.63

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Evande, RE; Grem, JL; Kos, ME; Meza, JL; Schwarz, JK	1

Reviews

1 review(s) available for 10-propargyl-10-deazaaminopterin and fluorouracil

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for 10-propargyl-10-deazaaminopterin and fluorouracil

Article	Year
A phase 1 clinical trial of sequential pralatrexate followed by a 48-hour infusion of 5-fluorouracil given every other week in adult patients with solid tumors. Cancer, 2015, Nov-01, Volume: 121, Issue:21 Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Incidence; Male; Middle Aged; Mucositis; Pancreatic Neoplasms; Polymorphism, Genetic; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Time Factors; Treatment Outcome	2015

Article

Year

A phase 1 clinical trial of sequential pralatrexate followed by a 48-hour infusion of 5-fluorouracil given every other week in adult patients with solid tumors.

Cancer, 2015, Nov-01, Volume: 121, Issue:21

Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Incidence; Male; Middle Aged; Mucositis; Pancreatic Neoplasms; Polymorphism, Genetic; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Time Factors; Treatment Outcome

2015