10-hydroxycarbamazepine has been researched along with eslicarbazepine acetate in 13 studies
| Studies (10-hydroxycarbamazepine) | Trials (10-hydroxycarbamazepine) | Recent Studies (post-2010) (10-hydroxycarbamazepine) | Studies (eslicarbazepine acetate) | Trials (eslicarbazepine acetate) | Recent Studies (post-2010) (eslicarbazepine acetate) |
|---|---|---|---|---|---|
| 106 | 20 | 30 | 229 | 68 | 175 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Alves, PC; Benes, J; Cunha, RA; Figueiredo, AA; Freitas, AP; Garrett, J; Learmonth, DA; Parada, A; Soares-da-Silva, P | 1 |
| Abdelrahman, A; Dosa, S; El-Tayeb, A; Hinz, S; Müller, CE; Tian, M; Weinhausen, S; Weyer, S | 1 |
| Hainzl, D; Parada, A; Soares-da-Silva, P | 1 |
| Almeida, L; Soares-da-Silva, P | 1 |
| Alves, G; Caramona, M; Castel-Branco, M; Falcão, A; Figueiredo, I; Loureiro, A | 1 |
| Alves, G; Falcão, A; Fortuna, A; Soares-da-Silva, P; Sousa, J | 1 |
| Chandrasekhar, KB; Mone, MK | 1 |
| Almeida, L; Elger, C; Falcão, A; Halász, P; Perucca, E; Soares-da-Silva, P | 1 |
| Fernandes-Lopes, C; Loureiro, AI; Soares-da-Silva, P; Wright, LC | 1 |
| Almeida, L; Falcão, A; Nunes, T; Rocha, JF; Soares-da-Silva, P | 1 |
| Blum, D; Cheng, H; Kharidia, J; Schutz, R; Sunkaraneni, S | 1 |
| Crommen, J; Fillet, M; Janicot, B; Servais, AC; Takam, A | 1 |
| Bak, LK; Jakobsen, E; Krarup, S; Lindholm, SEH; Mertz, C; Pinborg, LH | 1 |
4 trial(s) available for 10-hydroxycarbamazepine and eslicarbazepine acetate
| Article | Year |
|---|---|
Safety, tolerability, and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Carbamazepine; Dibenzazepines; Dose-Response Relationship, Drug; Double-Blind Method; Half-Life; Humans; Male; Middle Aged; Oxcarbazepine; Tablets | 2004 |
Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures.
Topics: Adult; Anticonvulsants; Carbamazepine; Dibenzazepines; Dose-Response Relationship, Drug; Female; Humans; International Cooperation; Male; Middle Aged; Oxcarbazepine; Seizures; Tandem Mass Spectrometry; Time Factors; Young Adult | 2011 |
Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Dibenzazepines; Female; Humans; Male; Middle Aged | 2013 |
A Pharmacokinetic Study Comparing Eslicarbazepine Acetate Administered Orally as a Crushed or Intact Tablet in Healthy Volunteers.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Area Under Curve; Biological Availability; Cross-Over Studies; Dibenzazepines; Female; Humans; Male; Middle Aged; Tablets; Therapeutic Equivalency; Young Adult | 2016 |
9 other study(ies) available for 10-hydroxycarbamazepine and eslicarbazepine acetate
| Article | Year |
|---|---|
Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.
Topics: Amides; Animals; Anticonvulsants; Azepines; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Electroshock; In Vitro Techniques; Ion Channel Gating; Motor Activity; Prodrugs; Rats; Seizures; Sodium; Stereoisomerism; Structure-Activity Relationship; Synaptosomes | 1999 |
Carbamazepine derivatives with P2X4 receptor-blocking activity.
Topics: Adenosine Triphosphate; Animals; Calcium; Carbamazepine; Chemistry Techniques, Synthetic; Dibenzazepines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Mice; Purinergic P2X Receptor Antagonists; Rats; Receptors, Purinergic P2X4; Structure-Activity Relationship | 2014 |
Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(-)-10,11-dihydro-10-hydroxy carbamazepine.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Dibenzazepines; Humans; Liver; Male; Mice; Rabbits; Rats; Rats, Wistar; Stereoisomerism | 2001 |
Simultaneous and enantioselective liquid chromatographic determination of eslicarbazepine acetate, S-licarbazepine, R-licarbazepine and oxcarbazepine in mouse tissue samples using ultraviolet detection.
Topics: Animals; Calibration; Carbamazepine; Chromatography, Liquid; Dibenzazepines; Mice; Mice, Inbred Strains; Oxcarbazepine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism; Tissue Distribution | 2007 |
Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Dibenzazepines; Humans; Molecular Structure; Oxcarbazepine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 2010 |
Development of liquid chromatographic enantiomer separation methods and validation for the estimation of (R)-enantiomer in eslicarbazepine acetate.
Topics: Acetonitriles; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chlorine; Chromatography; Chromatography, Liquid; Dibenzazepines; Ethanol; Methylene Chloride; Organic Chemicals; Reproducibility of Results; Solvents; Stereoisomerism; Temperature | 2011 |
Development and validation of an enantioselective liquid-chromatography/tandem mass spectrometry method for the separation and quantification of eslicarbazepine acetate, eslicarbazepine, R-licarbazepine and oxcarbazepine in human plasma.
Topics: Carbamazepine; Chromatography, Liquid; Dibenzazepines; Drug Stability; Humans; Male; Oxcarbazepine; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry | 2011 |
Liquid chromatography separation of the chiral prodrug eslicarbazepine acetate and its main metabolites in polar organic mode. Application to their analysis after in vitro metabolism.
Topics: Acetic Acid; Acetonitriles; Carbamazepine; Cellulose; Chromatography, Liquid; Dibenzazepines; Diethylamines; Humans; Microsomes, Liver; Oxcarbazepine; Phenylcarbamates; Prodrugs; Solid Phase Extraction; Solvents; Stereoisomerism | 2016 |
Distinct effects on cAMP signaling of carbamazepine and its structural derivatives do not correlate with their clinical efficacy in epilepsy.
Topics: Adenylyl Cyclases; Anticonvulsants; Calcium Signaling; Carbamazepine; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dibenzazepines; Epilepsy; HEK293 Cells; Humans; Oxcarbazepine; Seizures; Signal Transduction; Treatment Outcome | 2020 |