Compounds > 10-hydroxycamptothecin

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10-hydroxycamptothecin and topotecan

10-hydroxycamptothecin has been researched along with topotecan in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (28.57)	18.2507
2000's	6 (42.86)	29.6817
2010's	4 (28.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Boehm, JC; Caranfa, MJ; Faucette, LF; Gallagher, G; Hecht, SM; Holden, KG; Jakas, DR; Johnson, RK; Kingsbury, WD; McCabe, FL	1
Burke, TG; Mi, Z	1
Besterman, JM; Leitner, P; Manikumar, G; Moore, L; Nicholas, AW; Tele, C; Truesdale, A; Wall, ME; Wani, MC	1
Bingcang, AL; Bom, D; Burke, TG; Chavan, AJ; Curran, DP; Du, W; Fraley, KA; Kohlhagen, G; Kruszewski, S; Latus, LJ; Pommier, Y; Thompson Strode, J; Zimmer, SG	1
Chen, Y; Ding, J; Gao, H; Huang, M; Li, C; Lu, W; Shen, H; Sun, J; Zhang, X	1
Jiang, C; Jin, W; Li, M; Lou, L; Tang, W; You, T; Zheng, C	1
Chen, XG; Chern, JW; Guo, QL; He, XG; Huang, CH; Li, TK; Li, ZY; Wang, XJ; Yang, Q; You, QD	1
Alloatti, D; Badaloni, E; Cabri, W; Castorina, M; Giannini, G; Pisano, C; Vesci, L	1
Abasolo, I; Bermejo, M; Cabañas, MJ; Corma, A; Gonzalez-Alvarez, I; Gonzalez-Alvarez, M; Mangas-Sanjuán, V; Rodriguez-Berna, G; Schwartz, S	1
Guo, Q; Li, Z; Liu, X; Xie, Z; Xu, X; You, Q; Zhao, Q; Zhong, Y	1
Shen, K; Sun, Z; Xu, X	1
Leu, YL; Prijovich, ZM; Roffler, SR	1
Li, Y; Liu, Y; Lu, A; Wang, S; You, Q	1
Dong, M; Ju, D; Li, J; Li, Y; Liu, Z; Meng, G; Tan, H; Wang, G; Zhang, Q	1

Other Studies

14 other study(ies) available for 10-hydroxycamptothecin and topotecan

Article	Year
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Line; Colonic Neoplasms; DNA, Superhelical; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Leukemia L1210; Lung Neoplasms; Melanoma, Experimental; Mice; Molecular Structure; Plasmids; Structure-Activity Relationship; Thymus Gland; Topoisomerase I Inhibitors; Transplantation, Heterologous	1991
The structural basis of camptothecin interactions with human serum albumin: impact on drug stability. Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1 Topics: Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Half-Life; Irinotecan; Kinetics; Lactones; Molecular Structure; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Topotecan	1994
Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. Journal of medicinal chemistry, 1993, Sep-03, Volume: 36, Issue:18 Topics: Animals; Antineoplastic Agents; Camptothecin; Female; Humans; Leukemia L1210; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred DBA; Molecular Conformation; Molecular Structure; Plants, Medicinal; Stereoisomerism; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured	1993
The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity. Journal of medicinal chemistry, 2000, Oct-19, Volume: 43, Issue:21 Topics: Animals; Antineoplastic Agents; Camptothecin; DNA; Drug Screening Assays, Antitumor; Drug Stability; Electrophoresis, Agar Gel; Humans; Hydrolysis; Kinetics; Mice; Mice, Nude; Organosilicon Compounds; Spectrometry, Fluorescence; Structure-Activity Relationship; Tumor Cells, Cultured	2000
Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin. Bioorganic & medicinal chemistry letters, 2005, Apr-15, Volume: 15, Issue:8 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Humans	2005
7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Colorectal Neoplasms; Drug Design; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Hydrolysis; Inhibitory Concentration 50; Irinotecan; Models, Chemical; Rhodamines; Structure-Activity Relationship; Topotecan	2009
Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification. Journal of medicinal chemistry, 2009, Sep-24, Volume: 52, Issue:18 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Drug Discovery; Enzyme Inhibitors; Female; Humans; Mice; Mice, Nude; Models, Molecular; Molecular Conformation; Naphthyridines; Neoplasms; Quinolones; Topoisomerase I Inhibitors; Transplantation, Heterologous	2009
Camptothecins in tumor homing via an RGD sequence mimetic. Bioorganic & medicinal chemistry letters, 2012, Oct-15, Volume: 22, Issue:20 Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Integrins; Male; Oligopeptides; Ovarian Neoplasms; Prostatic Neoplasms; Rats	2012
Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives. ACS medicinal chemistry letters, 2013, Jul-11, Volume: 4, Issue:7 Topics:	2013
Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors. Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Drug Design; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Isoquinolines; Structure-Activity Relationship; Topoisomerase I Inhibitors	2016
[The effect of hydroxycamptothecin and topotecan to SKOV3 and CAOV3 in vitro]. Zhonghua fu chan ke za zhi, 1999, Volume: 34, Issue:9 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Division; Cystadenocarcinoma, Papillary; Cystadenocarcinoma, Serous; Female; Humans; Ovarian Neoplasms; Topotecan; Tumor Cells, Cultured	1999
Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin. Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; DNA Fragmentation; Dose-Response Relationship, Drug; Glucuronidase; Glucuronides; Humans; Hybridomas; Hydrogen-Ion Concentration; Hydrolysis; Immunoconjugates; Inhibitory Concentration 50; Irinotecan; Lactones; Molecular Structure; Prodrugs; Serum Albumin; Thymidine; Time Factors; Topotecan; Tritium	2007
Novel hexacyclic camptothecin derivatives. Part 1: synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ring. Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Models, Chemical; Oxazines; Topotecan	2008
Synthesis of novel 10-hydroxycamptothecin derivatives utilizing topotecan hydrochloride as ortho-quinonemethide precursor. Bioorganic & medicinal chemistry, 2015, Jan-01, Volume: 23, Issue:1 Topics: Antineoplastic Agents; Camptothecin; Cycloaddition Reaction; Hep G2 Cells; Humans; KB Cells; Molecular Docking Simulation; Quinones; Topotecan	2015