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10-deazaaminopterin and methotrexate

10-deazaaminopterin has been researched along with methotrexate in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199012 (52.17)18.7374
1990's11 (47.83)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abraham, A; Galivan, J; Gaumont, Y; Kisliuk, RL; McGuire, JJ; Nair, MG; Nimec, Z1
Christie, PH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sirotnak, FM1
Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG; Nanavati, NT1
Bridges, TW; Gaumont, Y; Henkel, TJ; Kisliuk, RL; Nair, MG; Sirotnak, FM1
Brown, VH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sirotnak, FM; Tagawa, H1
Colwell, WT; DeGraw, JI; Piper, JR; Sirotnak, FM2
Colwell, WT; Crase, J; DeGraw, JI; Piper, JR; Sirotnak, FM; Smith, RL; Waud, WR1
DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM1
Alarcón, GS; Castañeda, O; Ferrándiz, M; Koopman, WJ; Krumdieck, CL1
Baggott, JE; Freeberg, LE; Gay, RE; Gay, S; Gopal Nair, M; Hudson, BB; Koopman, WJ; Krumdieck, CL; Morgan, SL; Vaughn, WH1
Alarcón, GS; Castañeda, O; Ferrándiz, M; Koopman, WJ; Krumdieck, CL; Nair, MG1
McCord, JM; Nair, MG; Weber, GF1
Cheng, YC; Degraw, JI; Dutschman, GE; Nair, MG; Sirotnak, FM; Ueda, T1
Baugh, CM; Gaumont, Y; Kaufman, BT; Kisliuk, RL; Kumar, P; Nair, MG1
Freisheim, JH; Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG1
Moccio, DM; Samuels, LL; Sirotnak, FM1
DeGraw, JI; Otter, GM; Schmid, FA; Sirotnak, FM1
Moccio, DM; Sirotnak, FM; Yang, CH1
DeGraw, JI; Goutas, LJ; Moccio, DM; Schmid, FA; Sirotnak, FM1
Chello, PL; DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM1
Abraham, A; Galivan, J; McGuire, JJ; Nair, MG; Vishnuvajjala, BR1
Chiao, JH; Roy, K; Sirotnak, FM; Tolner, B1

Trials

2 trial(s) available for 10-deazaaminopterin and methotrexate

ArticleYear
Efficacy and safety of 10-deazaaminopterin in the treatment of rheumatoid arthritis. A one-year continuation, double-blind study.
    Arthritis and rheumatism, 1992, Volume: 35, Issue:11

    Topics: Adult; Alkaline Phosphatase; Aminopterin; Arthritis, Rheumatoid; Aspartate Aminotransferases; Double-Blind Method; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged

1992
Controlled trial of methotrexate versus 10-deazaaminopterin in the treatment of rheumatoid arthritis.
    Annals of the rheumatic diseases, 1992, Volume: 51, Issue:5

    Topics: Aminopterin; Arthritis, Rheumatoid; Double-Blind Method; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Treatment Outcome

1992

Other Studies

21 other study(ies) available for 10-deazaaminopterin and methotrexate

ArticleYear
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Indicators and Reagents; Methotrexate; Molecular Structure; Recombinant Proteins; Structure-Activity Relationship

1991
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: Aminopterin; Animals; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Methotrexate; Molecular Structure; Tumor Cells, Cultured

1990
Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:1

    Topics: Aminopterin; Animals; Anti-Bacterial Agents; Female; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Humans; Lacticaseibacillus casei; Methotrexate; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Peptides; Polyglutamic Acid; Streptococcus; Structure-Activity Relationship; Substrate Specificity

1988
Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:9

    Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chemical Phenomena; Chemistry; Lacticaseibacillus casei; Leukemia L1210; Mice; Streptococcus

1981
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:10

    Topics: Aminopterin; Animals; Antineoplastic Agents; Bacteria; Chemical Phenomena; Chemistry; Kinetics; Leukemia L1210; Mice

1982
Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.
    Journal of medicinal chemistry, 1993, Jul-23, Volume: 36, Issue:15

    Topics: Aminopterin; Animals; Antineoplastic Agents; Female; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Structure-Activity Relationship

1993
Analogues of methotrexate in rheumatoid arthritis. 1. Effects of 10-deazaaminopterin analogues on type II collagen-induced arthritis in mice.
    Journal of medicinal chemistry, 1997, Jan-31, Volume: 40, Issue:3

    Topics: Aminopterin; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Cell Survival; Collagen; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methotrexate; Mice; Molecular Structure; Tumor Cells, Cultured

1997
Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.
    Cancer treatment reports, 1978, Volume: 62, Issue:7

    Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Drug Evaluation, Preclinical; Female; Folic Acid; Leukemia L1210; Liver Neoplasms; Male; Methotrexate; Mice; Neoplasms, Experimental; Plasmacytoma; Sarcoma 180

1978
Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin.
    Agents and actions, 1992, Volume: 35, Issue:1-2

    Topics: Aminopterin; Animals; Autoimmune Diseases; Blood Urea Nitrogen; Dermatitis; Disease Models, Animal; Female; Joints; Lymph Nodes; Methotrexate; Mice; Proteinuria

1992
The antifolate 10-deazaaminopterin inhibits neutrophil chemotaxis and superoxide generation.
    Immunopharmacology and immunotoxicology, 1991, Volume: 13, Issue:3

    Topics: Adult; Aminopterin; Cell Degranulation; Cells, Cultured; Chemotaxis, Leukocyte; Female; Folic Acid; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Superoxides

1991
Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.
    Molecular pharmacology, 1986, Volume: 30, Issue:2

    Topics: Alkylation; Aminopterin; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Methylation; Peptides; Polyglutamic Acid; Structure-Activity Relationship; Thymidylate Synthase

1986
Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase.
    Cancer research, 1986, Volume: 46, Issue:10

    Topics: Aminopterin; Animals; Cattle; Chickens; Folic Acid; Folic Acid Antagonists; Methotrexate; Peptides; Polyglutamic Acid; Potassium Chloride; Sheep; Structure-Activity Relationship

1986
Inhibition of human dihydrofolate reductase by antifolyl polyglutamates.
    Biochemical pharmacology, 1989, Feb-01, Volume: 38, Issue:3

    Topics: Aminopterin; Folic Acid Antagonists; Humans; Methotrexate; Peptides; Polyglutamic Acid

1989
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
    Cancer research, 1985, Volume: 45, Issue:4

    Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay

1985
New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.
    Cancer treatment reports, 1985, Volume: 69, Issue:5

    Topics: Aminopterin; Animals; Antineoplastic Agents; Female; Folic Acid Antagonists; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous

1985
Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.
    Cancer research, 1984, Volume: 44, Issue:11

    Topics: Aminopterin; Animals; Biological Transport; Cell Division; DNA Replication; Epithelial Cells; Epithelium; Folic Acid Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Intestine, Small; Kinetics; Male; Methotrexate; Mice; Mice, Inbred Strains; Tetrahydrofolate Dehydrogenase; Thermodynamics

1984
New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models.
    Cancer chemotherapy and pharmacology, 1984, Volume: 12, Issue:1

    Topics: Aminopterin; Animals; Drug Evaluation, Preclinical; Female; Methotrexate; Mice; Neoplasms, Experimental; Structure-Activity Relationship

1984
Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice.
    Cancer treatment reports, 1982, Volume: 66, Issue:2

    Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Membranes; Methotrexate; Mice; Sarcoma 180; Tetrahydrofolate Dehydrogenase

1982
New thiophene substituted 10-deazaaminopterins: synthesis and biological evaluation.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Glutamates; Humans; Male; Methotrexate; Mice; Pterins; Rats; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured

1993
A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within
    The Journal of biological chemistry, 1998, Jan-30, Volume: 273, Issue:5

    Topics: Amino Acid Sequence; Aminopterin; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Membrane; Drug Resistance, Neoplasm; Folic Acid Antagonists; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Protein Conformation; Sarcoma 180; Sequence Homology, Amino Acid; Tumor Cells, Cultured

1998
A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:4

    Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Methotrexate; Mice; Mice, Nude; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured

1998