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10-deazaaminopterin and aminopterin

10-deazaaminopterin has been researched along with aminopterin in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199020 (66.67)18.7374
1990's9 (30.00)18.2507
2000's1 (3.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abraham, A; Galivan, J; Gaumont, Y; Kisliuk, RL; McGuire, JJ; Nair, MG; Nimec, Z1
Bridges, TW; Gaumont, Y; Henkel, TJ; Kisliuk, RL; Nair, MG; Sirotnak, FM1
Brown, VH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sirotnak, FM; Tagawa, H1
DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM1
Alarcón, GS; Castañeda, O; Ferrándiz, M; Koopman, WJ; Krumdieck, CL1
Baggott, JE; Freeberg, LE; Gay, RE; Gay, S; Gopal Nair, M; Hudson, BB; Koopman, WJ; Krumdieck, CL; Morgan, SL; Vaughn, WH1
Alarcón, GS; Castañeda, O; Ferrándiz, M; Koopman, WJ; Krumdieck, CL; Nair, MG1
McCord, JM; Nair, MG; Weber, GF1
Fanucchi, MP; Farag, F; Kinahan, JJ; Samuels, LL; Sirotnak, FM; Vidal, PM; Young, CW1
Cheng, YC; Degraw, JI; Dutschman, GE; Nair, MG; Sirotnak, FM; Ueda, T1
Baugh, CM; Gaumont, Y; Kaufman, BT; Kisliuk, RL; Kumar, P; Nair, MG1
Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG; Nanavati, NT1
Freisheim, JH; Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG1
Ahmed, T; Scher, HI; Sternberg, C; Watson, RC; Yagoda, A1
Budman, D; Currie, VE; Thongprasert, S1
Moccio, DM; Samuels, LL; Sirotnak, FM1
DeGraw, JI; Otter, GM; Schmid, FA; Sirotnak, FM1
Baugh, CM; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Nair, MG1
Moccio, DM; Sirotnak, FM; Yang, CH1
DeGraw, JI; Goutas, LJ; Moccio, DM; Samuels, LL; Sirotnak, FM1
DeGraw, JI; Goutas, LJ; Moccio, DM; Schmid, FA; Sirotnak, FM1
Arlin, Z; Currie, VE; Greene, G; Sirotnak, FM; Tan, C; Warrell, RP; Young, CW1
Cheng, EW; Currie, VE; Yagoda, A1
Chello, PL; DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM1
Montgomery, JA; Piper, JR1
Abraham, A; Galivan, J; McGuire, JJ; Nair, MG; Vishnuvajjala, BR1
Johnson, CA; Otter, GM; Piper, JR; Ramamurthy, B; Sirotnak, FM1
Chiao, JH; Roy, K; Sirotnak, FM; Tolner, B1
Colwell, WT; DeGraw, JI; Piper, JR; Sirotnak, FM1
Bornmann, WG; Kris, MG; Miller, VA; Scher, HI; Sirotnak, FM; Tong, WP; Wendel, HG1

Trials

2 trial(s) available for 10-deazaaminopterin and aminopterin

ArticleYear
Efficacy and safety of 10-deazaaminopterin in the treatment of rheumatoid arthritis. A one-year continuation, double-blind study.
    Arthritis and rheumatism, 1992, Volume: 35, Issue:11

    Topics: Adult; Alkaline Phosphatase; Aminopterin; Arthritis, Rheumatoid; Aspartate Aminotransferases; Double-Blind Method; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged

1992
Controlled trial of methotrexate versus 10-deazaaminopterin in the treatment of rheumatoid arthritis.
    Annals of the rheumatic diseases, 1992, Volume: 51, Issue:5

    Topics: Aminopterin; Arthritis, Rheumatoid; Double-Blind Method; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Treatment Outcome

1992

Other Studies

28 other study(ies) available for 10-deazaaminopterin and aminopterin

ArticleYear
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Indicators and Reagents; Methotrexate; Molecular Structure; Recombinant Proteins; Structure-Activity Relationship

1991
Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:9

    Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chemical Phenomena; Chemistry; Lacticaseibacillus casei; Leukemia L1210; Mice; Streptococcus

1981
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:10

    Topics: Aminopterin; Animals; Antineoplastic Agents; Bacteria; Chemical Phenomena; Chemistry; Kinetics; Leukemia L1210; Mice

1982
Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.
    Cancer treatment reports, 1978, Volume: 62, Issue:7

    Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Drug Evaluation, Preclinical; Female; Folic Acid; Leukemia L1210; Liver Neoplasms; Male; Methotrexate; Mice; Neoplasms, Experimental; Plasmacytoma; Sarcoma 180

1978
Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin.
    Agents and actions, 1992, Volume: 35, Issue:1-2

    Topics: Aminopterin; Animals; Autoimmune Diseases; Blood Urea Nitrogen; Dermatitis; Disease Models, Animal; Female; Joints; Lymph Nodes; Methotrexate; Mice; Proteinuria

1992
The antifolate 10-deazaaminopterin inhibits neutrophil chemotaxis and superoxide generation.
    Immunopharmacology and immunotoxicology, 1991, Volume: 13, Issue:3

    Topics: Adult; Aminopterin; Cell Degranulation; Cells, Cultured; Chemotaxis, Leukocyte; Female; Folic Acid; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Superoxides

1991
Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites.
    Analytical biochemistry, 1985, Volume: 150, Issue:1

    Topics: Aminopterin; Animals; Chromatography, High Pressure Liquid; Humans; Leukemia L1210; Mice; Mice, Nude; Neoplasms; Polyglutamic Acid; Spectrometry, Fluorescence

1985
Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.
    Molecular pharmacology, 1986, Volume: 30, Issue:2

    Topics: Alkylation; Aminopterin; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Methylation; Peptides; Polyglutamic Acid; Structure-Activity Relationship; Thymidylate Synthase

1986
Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase.
    Cancer research, 1986, Volume: 46, Issue:10

    Topics: Aminopterin; Animals; Cattle; Chickens; Folic Acid; Folic Acid Antagonists; Methotrexate; Peptides; Polyglutamic Acid; Potassium Chloride; Sheep; Structure-Activity Relationship

1986
Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:1

    Topics: Aminopterin; Animals; Anti-Bacterial Agents; Female; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Humans; Lacticaseibacillus casei; Methotrexate; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Peptides; Polyglutamic Acid; Streptococcus; Structure-Activity Relationship; Substrate Specificity

1988
Inhibition of human dihydrofolate reductase by antifolyl polyglutamates.
    Biochemical pharmacology, 1989, Feb-01, Volume: 38, Issue:3

    Topics: Aminopterin; Folic Acid Antagonists; Humans; Methotrexate; Peptides; Polyglutamic Acid

1989
Phase II trial of 10 deaza-aminopterin in patients with bladder cancer.
    Investigational new drugs, 1986, Volume: 4, Issue:2

    Topics: Aged; Aminopterin; Antineoplastic Agents; Carcinoma, Transitional Cell; Drug Evaluation; Female; Humans; Male; Middle Aged; Urinary Bladder Neoplasms

1986
Phase II trial of 10-deaza-aminopterin in advanced breast cancer.
    Cancer treatment reports, 1987, Volume: 71, Issue:1

    Topics: Adult; Aged; Aminopterin; Breast Neoplasms; Drug Evaluation; Humans; Inflammation; Middle Aged; Mucous Membrane

1987
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
    Cancer research, 1985, Volume: 45, Issue:4

    Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay

1985
New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.
    Cancer treatment reports, 1985, Volume: 69, Issue:5

    Topics: Aminopterin; Animals; Antineoplastic Agents; Female; Folic Acid Antagonists; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous

1985
Synthesis and antifolate activity of 10-deazaminopterin.
    Journal of medicinal chemistry, 1974, Volume: 17, Issue:5

    Topics: Aminopterin; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid Antagonists; Lacticaseibacillus casei; Microbial Sensitivity Tests; Pediococcus; Thymidylate Synthase

1974
Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.
    Cancer research, 1984, Volume: 44, Issue:11

    Topics: Aminopterin; Animals; Biological Transport; Cell Division; DNA Replication; Epithelial Cells; Epithelium; Folic Acid Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Intestine, Small; Kinetics; Male; Methotrexate; Mice; Mice, Inbred Strains; Tetrahydrofolate Dehydrogenase; Thermodynamics

1984
New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties.
    Cancer chemotherapy and pharmacology, 1984, Volume: 12, Issue:1

    Topics: Aminopterin; Animals; Cells, Cultured; Epithelium; Female; Folic Acid Antagonists; Intestine, Small; Kinetics; Mice; Structure-Activity Relationship

1984
New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models.
    Cancer chemotherapy and pharmacology, 1984, Volume: 12, Issue:1

    Topics: Aminopterin; Animals; Drug Evaluation, Preclinical; Female; Methotrexate; Mice; Neoplasms, Experimental; Structure-Activity Relationship

1984
Phase I trial of 10-deaza-aminopterin in patients with advanced cancer.
    Cancer treatment reports, 1983, Volume: 67, Issue:2

    Topics: Adult; Aminopterin; Bone Marrow; Drug Administration Schedule; Drug Evaluation; Folic Acid Antagonists; Humans; Infusions, Parenteral; Injections, Intravenous; Leukemia; Mucous Membrane; Skin

1983
Phase II trial of 10-deaza-aminopterin in patients with advanced colorectal cancer.
    American journal of clinical oncology, 1983, Volume: 6, Issue:4

    Topics: Adenocarcinoma; Aminopterin; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Humans; Rectal Neoplasms

1983
Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice.
    Cancer treatment reports, 1982, Volume: 66, Issue:2

    Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Membranes; Methotrexate; Mice; Sarcoma 180; Tetrahydrofolate Dehydrogenase

1982
Convenient synthesis of 10-deazaaminopterin via a pteridine ylide.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:3

    Topics: Aminopterin; Antineoplastic Agents; Methods; Pteridines

1980
New thiophene substituted 10-deazaaminopterins: synthesis and biological evaluation.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Glutamates; Humans; Male; Methotrexate; Mice; Pterins; Rats; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured

1993
Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl.
    Journal of medicinal chemistry, 1996, Jan-19, Volume: 39, Issue:2

    Topics: Adenocarcinoma; Alkylation; Aminopterin; Animals; Antineoplastic Agents; Cell Division; Mammary Neoplasms, Experimental; Mice; Tumor Cells, Cultured

1996
A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within
    The Journal of biological chemistry, 1998, Jan-30, Volume: 273, Issue:5

    Topics: Amino Acid Sequence; Aminopterin; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Membrane; Drug Resistance, Neoplasm; Folic Acid Antagonists; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Protein Conformation; Sarcoma 180; Sequence Homology, Amino Acid; Tumor Cells, Cultured

1998
A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:4

    Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Methotrexate; Mice; Mice, Nude; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured

1998
Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:9

    Topics: Adenosine Triphosphatases; Aminopterin; Animals; Anion Transport Proteins; Antineoplastic Combined Chemotherapy Protocols; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Membrane; Drug Synergism; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Mice; Multidrug Resistance-Associated Proteins; Neoplasms, Experimental; Probenecid; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000