10-deazaaminopterin has been researched along with aminopterin in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (66.67) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 1 (3.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abraham, A; Galivan, J; Gaumont, Y; Kisliuk, RL; McGuire, JJ; Nair, MG; Nimec, Z | 1 |
| Bridges, TW; Gaumont, Y; Henkel, TJ; Kisliuk, RL; Nair, MG; Sirotnak, FM | 1 |
| Brown, VH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sirotnak, FM; Tagawa, H | 1 |
| DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| Alarcón, GS; Castañeda, O; Ferrándiz, M; Koopman, WJ; Krumdieck, CL | 1 |
| Baggott, JE; Freeberg, LE; Gay, RE; Gay, S; Gopal Nair, M; Hudson, BB; Koopman, WJ; Krumdieck, CL; Morgan, SL; Vaughn, WH | 1 |
| Alarcón, GS; Castañeda, O; Ferrándiz, M; Koopman, WJ; Krumdieck, CL; Nair, MG | 1 |
| McCord, JM; Nair, MG; Weber, GF | 1 |
| Fanucchi, MP; Farag, F; Kinahan, JJ; Samuels, LL; Sirotnak, FM; Vidal, PM; Young, CW | 1 |
| Cheng, YC; Degraw, JI; Dutschman, GE; Nair, MG; Sirotnak, FM; Ueda, T | 1 |
| Baugh, CM; Gaumont, Y; Kaufman, BT; Kisliuk, RL; Kumar, P; Nair, MG | 1 |
| Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG; Nanavati, NT | 1 |
| Freisheim, JH; Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG | 1 |
| Ahmed, T; Scher, HI; Sternberg, C; Watson, RC; Yagoda, A | 1 |
| Budman, D; Currie, VE; Thongprasert, S | 1 |
| Moccio, DM; Samuels, LL; Sirotnak, FM | 1 |
| DeGraw, JI; Otter, GM; Schmid, FA; Sirotnak, FM | 1 |
| Baugh, CM; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Nair, MG | 1 |
| Moccio, DM; Sirotnak, FM; Yang, CH | 1 |
| DeGraw, JI; Goutas, LJ; Moccio, DM; Samuels, LL; Sirotnak, FM | 1 |
| DeGraw, JI; Goutas, LJ; Moccio, DM; Schmid, FA; Sirotnak, FM | 1 |
| Arlin, Z; Currie, VE; Greene, G; Sirotnak, FM; Tan, C; Warrell, RP; Young, CW | 1 |
| Cheng, EW; Currie, VE; Yagoda, A | 1 |
| Chello, PL; DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| Montgomery, JA; Piper, JR | 1 |
| Abraham, A; Galivan, J; McGuire, JJ; Nair, MG; Vishnuvajjala, BR | 1 |
| Johnson, CA; Otter, GM; Piper, JR; Ramamurthy, B; Sirotnak, FM | 1 |
| Chiao, JH; Roy, K; Sirotnak, FM; Tolner, B | 1 |
| Colwell, WT; DeGraw, JI; Piper, JR; Sirotnak, FM | 1 |
| Bornmann, WG; Kris, MG; Miller, VA; Scher, HI; Sirotnak, FM; Tong, WP; Wendel, HG | 1 |
2 trial(s) available for 10-deazaaminopterin and aminopterin
| Article | Year |
|---|---|
Efficacy and safety of 10-deazaaminopterin in the treatment of rheumatoid arthritis. A one-year continuation, double-blind study.
Topics: Adult; Alkaline Phosphatase; Aminopterin; Arthritis, Rheumatoid; Aspartate Aminotransferases; Double-Blind Method; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged | 1992 |
Controlled trial of methotrexate versus 10-deazaaminopterin in the treatment of rheumatoid arthritis.
Topics: Aminopterin; Arthritis, Rheumatoid; Double-Blind Method; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Treatment Outcome | 1992 |
28 other study(ies) available for 10-deazaaminopterin and aminopterin
| Article | Year |
|---|---|
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Indicators and Reagents; Methotrexate; Molecular Structure; Recombinant Proteins; Structure-Activity Relationship | 1991 |
Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.
Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chemical Phenomena; Chemistry; Lacticaseibacillus casei; Leukemia L1210; Mice; Streptococcus | 1981 |
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Bacteria; Chemical Phenomena; Chemistry; Kinetics; Leukemia L1210; Mice | 1982 |
Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.
Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Drug Evaluation, Preclinical; Female; Folic Acid; Leukemia L1210; Liver Neoplasms; Male; Methotrexate; Mice; Neoplasms, Experimental; Plasmacytoma; Sarcoma 180 | 1978 |
Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin.
Topics: Aminopterin; Animals; Autoimmune Diseases; Blood Urea Nitrogen; Dermatitis; Disease Models, Animal; Female; Joints; Lymph Nodes; Methotrexate; Mice; Proteinuria | 1992 |
The antifolate 10-deazaaminopterin inhibits neutrophil chemotaxis and superoxide generation.
Topics: Adult; Aminopterin; Cell Degranulation; Cells, Cultured; Chemotaxis, Leukocyte; Female; Folic Acid; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Superoxides | 1991 |
Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites.
Topics: Aminopterin; Animals; Chromatography, High Pressure Liquid; Humans; Leukemia L1210; Mice; Mice, Nude; Neoplasms; Polyglutamic Acid; Spectrometry, Fluorescence | 1985 |
Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.
Topics: Alkylation; Aminopterin; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Methylation; Peptides; Polyglutamic Acid; Structure-Activity Relationship; Thymidylate Synthase | 1986 |
Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase.
Topics: Aminopterin; Animals; Cattle; Chickens; Folic Acid; Folic Acid Antagonists; Methotrexate; Peptides; Polyglutamic Acid; Potassium Chloride; Sheep; Structure-Activity Relationship | 1986 |
Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.
Topics: Aminopterin; Animals; Anti-Bacterial Agents; Female; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Humans; Lacticaseibacillus casei; Methotrexate; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Peptides; Polyglutamic Acid; Streptococcus; Structure-Activity Relationship; Substrate Specificity | 1988 |
Inhibition of human dihydrofolate reductase by antifolyl polyglutamates.
Topics: Aminopterin; Folic Acid Antagonists; Humans; Methotrexate; Peptides; Polyglutamic Acid | 1989 |
Phase II trial of 10 deaza-aminopterin in patients with bladder cancer.
Topics: Aged; Aminopterin; Antineoplastic Agents; Carcinoma, Transitional Cell; Drug Evaluation; Female; Humans; Male; Middle Aged; Urinary Bladder Neoplasms | 1986 |
Phase II trial of 10-deaza-aminopterin in advanced breast cancer.
Topics: Adult; Aged; Aminopterin; Breast Neoplasms; Drug Evaluation; Humans; Inflammation; Middle Aged; Mucous Membrane | 1987 |
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay | 1985 |
New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Female; Folic Acid Antagonists; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous | 1985 |
Synthesis and antifolate activity of 10-deazaminopterin.
Topics: Aminopterin; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid Antagonists; Lacticaseibacillus casei; Microbial Sensitivity Tests; Pediococcus; Thymidylate Synthase | 1974 |
Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.
Topics: Aminopterin; Animals; Biological Transport; Cell Division; DNA Replication; Epithelial Cells; Epithelium; Folic Acid Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Intestine, Small; Kinetics; Male; Methotrexate; Mice; Mice, Inbred Strains; Tetrahydrofolate Dehydrogenase; Thermodynamics | 1984 |
New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties.
Topics: Aminopterin; Animals; Cells, Cultured; Epithelium; Female; Folic Acid Antagonists; Intestine, Small; Kinetics; Mice; Structure-Activity Relationship | 1984 |
New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models.
Topics: Aminopterin; Animals; Drug Evaluation, Preclinical; Female; Methotrexate; Mice; Neoplasms, Experimental; Structure-Activity Relationship | 1984 |
Phase I trial of 10-deaza-aminopterin in patients with advanced cancer.
Topics: Adult; Aminopterin; Bone Marrow; Drug Administration Schedule; Drug Evaluation; Folic Acid Antagonists; Humans; Infusions, Parenteral; Injections, Intravenous; Leukemia; Mucous Membrane; Skin | 1983 |
Phase II trial of 10-deaza-aminopterin in patients with advanced colorectal cancer.
Topics: Adenocarcinoma; Aminopterin; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Humans; Rectal Neoplasms | 1983 |
Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice.
Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Membranes; Methotrexate; Mice; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1982 |
Convenient synthesis of 10-deazaaminopterin via a pteridine ylide.
Topics: Aminopterin; Antineoplastic Agents; Methods; Pteridines | 1980 |
New thiophene substituted 10-deazaaminopterins: synthesis and biological evaluation.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Glutamates; Humans; Male; Methotrexate; Mice; Pterins; Rats; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 1993 |
Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl.
Topics: Adenocarcinoma; Alkylation; Aminopterin; Animals; Antineoplastic Agents; Cell Division; Mammary Neoplasms, Experimental; Mice; Tumor Cells, Cultured | 1996 |
A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within
Topics: Amino Acid Sequence; Aminopterin; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Membrane; Drug Resistance, Neoplasm; Folic Acid Antagonists; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Protein Conformation; Sarcoma 180; Sequence Homology, Amino Acid; Tumor Cells, Cultured | 1998 |
A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Methotrexate; Mice; Mice, Nude; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1998 |
Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo.
Topics: Adenosine Triphosphatases; Aminopterin; Animals; Anion Transport Proteins; Antineoplastic Combined Chemotherapy Protocols; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Membrane; Drug Synergism; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Mice; Multidrug Resistance-Associated Proteins; Neoplasms, Experimental; Probenecid; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2000 |