10(9)-hydroxystearic-acid and palmitoleic-acid

Fatty acid esters of hydroxy fatty acids (FAHFAs) are newly discovered long-chain fatty acids. However, the major endogenous FAHFAs in healthy human circulation, their correlation with cardiovascular (CV) biomarkers, and their anti-inflammatory effects have not been investigated and remain unclear. In the present study, a total of 57 healthy subjects were recruited. Liquid chromatography-mass spectrometry (LC-MS) was developed for the simultaneous determination of seven FAHFAs, four long-chain fatty acids, and four non-traditional circulating CV-related biomarkers. We found two major types of FAHFAs in healthy human circulation, palmitoleic acid ester of 9-hydroxystearic acid (9-POHSA), and oleic acid ester of 9-hydroxystearic acid (9-OAHSA). Both 9-POHSA and 9-OAHSA had a strong positive correlation with each other and were negatively correlated with fasting blood glucose,

Topics: Adult; Aged; Animals; Anti-Inflammatory Agents; Biomarkers; Calibration; Cardiovascular Diseases; Carnitine; Cytokines; Esters; Fatty Acids; Fatty Acids, Monounsaturated; Humans; Lipopolysaccharides; Mice; Middle Aged; Prospective Studies; RAW 264.7 Cells; Risk Factors; Stearic Acids