Compounds > 1-phenethylamine--(r)-isomer

1-phenethylamine--(r)-isomer and 1-phenethylamine

1-phenethylamine--(r)-isomer has been researched along with 1-phenethylamine* in 1 studies

Other Studies

1 other study(ies) available for 1-phenethylamine--(r)-isomer and 1-phenethylamine

Article	Year
Probes of the active site of norepinephrine N-methyltransferase: effect of hydrophobic and hydrophilic interactions on side-chain binding of amphetamine and alpha-methylbenzylamine. Journal of medicinal chemistry, 1982, Volume: 25, Issue:10 A series of omega-substituted analogues of amphetamine and alpha-methylbenzylamine were prepared and evaluated as inhibitors of norepinephrine N-methyltransferase (NMT). These included several alkyl side chain extended analogues (1-5), as well as the terminally hydroxylated derivatives phenylalanol (6a) and phenylglycinol (7a). None of the alkyl-substituted derivatives displayed appreciable activity as inhibitors; however, the hydroxylated analogues were up to twofold more potent than the parent compounds. The positive contribution of the side-chain hydroxy suggests that the terminal methyl group of the lead compounds is situated close to a hydrophilic area or hydrogen bonding functional group within the active site. Topics: Amines; Amphetamines; Benzylamines; Binding Sites; Catalysis; Phenethylamines; Phenylethanolamine N-Methyltransferase; Structure-Activity Relationship	1982

Article

Year

Probes of the active site of norepinephrine N-methyltransferase: effect of hydrophobic and hydrophilic interactions on side-chain binding of amphetamine and alpha-methylbenzylamine.

Journal of medicinal chemistry, 1982, Volume: 25, Issue:10

A series of omega-substituted analogues of amphetamine and alpha-methylbenzylamine were prepared and evaluated as inhibitors of norepinephrine N-methyltransferase (NMT). These included several alkyl side chain extended analogues (1-5), as well as the terminally hydroxylated derivatives phenylalanol (6a) and phenylglycinol (7a). None of the alkyl-substituted derivatives displayed appreciable activity as inhibitors; however, the hydroxylated analogues were up to twofold more potent than the parent compounds. The positive contribution of the side-chain hydroxy suggests that the terminal methyl group of the lead compounds is situated close to a hydrophilic area or hydrogen bonding functional group within the active site.

Topics: Amines; Amphetamines; Benzylamines; Binding Sites; Catalysis; Phenethylamines; Phenylethanolamine N-Methyltransferase; Structure-Activity Relationship

1982