1-palmitoyl-2-oleoylphosphatidylethanolamine has been researched along with epicatechin-gallate* in 1 studies
1 other study(ies) available for 1-palmitoyl-2-oleoylphosphatidylethanolamine and epicatechin-gallate
| Article | Year |
|---|---|
A-type ECG and EGCG dimers inhibit 3T3-L1 differentiation by binding to cholesterol in lipid rafts.
The present study aimed to explore the underlying mechanisms of epicatechin-3-gallate-(4β→8, 2β→O→7)-epicatechin-3-gallate (A-type ECG dimer) and epigallocatechin-3-gallate-(4β→8, 2β→O→7)-epigallocatechin-3-gallate (A-type EGCG dimer) involved in their strong inhibitory effects on 3T3-L1 preadipocytes differentiation. In the synthetic "lipid raft-like" liposome, A-type ECG and EGCG dimers incorporated into the liposome with high affinity and decreased the fluidity of the liposome. In 3T3-L1 preadipocytes, A-type ECG and EGCG dimers possibly bonded to lipid rafts cholesterol and disrupted the integrity of lipid rafts, thus exerting their notable inhibitory effects on 3T3-L1 preadipocytes differentiation by suppressing mitotic clonal expansion process and mRNA levels of PPARγ, C/EBPα and SREBP1C. A highly positive correlation between the cholesterol binding capacity of the two dimers and their inhibitory effect on 3T3-L1 preadipocytes differentiation (R Topics: 3T3-L1 Cells; Adipocytes; Animals; Catechin; Cell Differentiation; Cholesterol; Dimerization; Lipid Bilayers; Membrane Microdomains; Mice; Microscopy, Fluorescence; Molecular Dynamics Simulation; Phosphatidylcholines; Phosphatidylethanolamines | 2017 |