1-palmitoyl-2-oleoylphosphatidylethanolamine--(z-&-r)-isomer and 1-2-hexanoylphosphatidylcholine

The spontaneously formed structures of physiologically relevant lipid model membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) and 1,2-hexanoyl-sn-glycero-3-phosphocholine have been evaluated in depth using small angle neutron scattering. Although a common molar ratio of long- to short- chain phospholipids (~4) as reported in many bicellar mixtures was used, discoidal bicelles were not found as the major phase throughout the range of lipid concentration and temperature studied, indicating that the required condition for the formation of bicelle is the immiscibility between the long- and short- chain lipids, which were in the gel and L

Topics: Lipid Bilayers; Membrane Fluidity; Membrane Lipids; Neutrons; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Scattering, Small Angle; Unilamellar Liposomes