Compounds > 1-palmitoyl-2-oleoylglycero-3-phosphoserine

1-palmitoyl-2-oleoylglycero-3-phosphoserine and inositol-3-4-bisphosphate

1-palmitoyl-2-oleoylglycero-3-phosphoserine has been researched along with inositol-3-4-bisphosphate* in 1 studies

Other Studies

1 other study(ies) available for 1-palmitoyl-2-oleoylglycero-3-phosphoserine and inositol-3-4-bisphosphate

Article	Year
Roles of PIP2 in the membrane binding of MIM I-BAR: insights from molecular dynamics simulations. FEBS letters, 2018, Volume: 592, Issue:15 In order to probe the roles of PIP2 in the interactions between MIM I-BAR and model membranes, we performed a series of 10 μs-scale coarse-grained molecular dynamics simulations. Our results indicate that PIP2 plays predominant roles in the membrane binding of MIM I-BAR in a concentration-dependent manner and via electrostatic interactions. Besides, we find that the occurrence of the membrane curvature may induce the re-distribution of lipids in the membrane and result in the local enrichment of PIP2 at negatively curved membrane areas. Combining these roles of PIP2 in the membrane binding of MIM I-BAR helps explain how MIM I-BAR senses negative curvature and, thus, contributes to maintaining membrane protrusions. Topics: Amino Acid Sequence; Cell Membrane; Humans; Inositol Phosphates; Lipid Bilayers; Microfilament Proteins; Molecular Dynamics Simulation; Neoplasm Proteins; Phosphatidylserines; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Tertiary; Static Electricity	2018

Article

Year

Roles of PIP2 in the membrane binding of MIM I-BAR: insights from molecular dynamics simulations.

FEBS letters, 2018, Volume: 592, Issue:15

In order to probe the roles of PIP2 in the interactions between MIM I-BAR and model membranes, we performed a series of 10 μs-scale coarse-grained molecular dynamics simulations. Our results indicate that PIP2 plays predominant roles in the membrane binding of MIM I-BAR in a concentration-dependent manner and via electrostatic interactions. Besides, we find that the occurrence of the membrane curvature may induce the re-distribution of lipids in the membrane and result in the local enrichment of PIP2 at negatively curved membrane areas. Combining these roles of PIP2 in the membrane binding of MIM I-BAR helps explain how MIM I-BAR senses negative curvature and, thus, contributes to maintaining membrane protrusions.

Topics: Amino Acid Sequence; Cell Membrane; Humans; Inositol Phosphates; Lipid Bilayers; Microfilament Proteins; Molecular Dynamics Simulation; Neoplasm Proteins; Phosphatidylserines; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Tertiary; Static Electricity

2018