Compounds > 1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8)

Page last updated: 2024-09-03

1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) and u-50488

1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) has been researched along with u-50488 in 5 studies

Compound Research Comparison

Studies (1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8))	Trials (1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8))	Recent Studies (post-2010) (1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8))	Studies (u-50488)	Trials (u-50488)	Recent Studies (post-2010) (u-50488)
35	2	0	1,664	3	209

Protein Interaction Comparison

Protein	Taxonomy	1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) (IC50)	u-50488 (IC50)
Delta-type opioid receptor	Rattus norvegicus (Norway rat)		2.15
Kappa-type opioid receptor	Mus musculus (house mouse)		0.0027
Mu-type opioid receptor	Rattus norvegicus (Norway rat)		2.15
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)		0.7171
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)		0.0958
Kappa-type opioid receptor	Homo sapiens (human)		0.0537

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (80.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX	1
Kaneko, T; Nakazawa, T; Yamanishi, Y	1
Furuya, Y; Kaneko, T; Nakazawa, T; Tachibana, S; Yamatsu, K; Yoshino, H	1
Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T	1
Ambo, A; Hiramatsu, M; Inoue, K; Kameyama, T; Sasaki, Y	1

Other Studies

5 other study(ies) available for 1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) and u-50488

Article	Year
Cloning and pharmacological characterization of a rat kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America, 1993, Nov-01, Volume: 90, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection	1993
A comparative study of monoaminergic involvement in the antinociceptive action of E-2078, morphine and U-50,488E. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Biogenic Monoamines; Drug Interactions; Dynorphins; Male; Mice; Morphine; Neurotoxins; Peptide Fragments; Pyrrolidines	1991
Analgesia produced by E-2078, a systemically active dynorphin analog, in mice. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Buprenorphine; Drug Interactions; Dynorphins; Male; Mice; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid	1990
Blockade of morphine reward through the activation of kappa-opioid receptors in mice. Neuropharmacology, 1993, Volume: 32, Issue:12 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Apomorphine; Conditioning, Operant; Dopamine; Dynorphins; Homovanillic Acid; Injections, Subcutaneous; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motivation; Naltrexone; Peptide Fragments; Prosencephalon; Pyrrolidines; Receptors, Opioid, kappa; Reward	1993
Long-lasting antinociceptive effects of a novel dynorphin analogue, Tyr-D-Ala-Phe-Leu-Arg psi (CH(2)NH) Arg-NH(2), in mice. British journal of pharmacology, 2001, Volume: 132, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Dynorphins; Guinea Pigs; Hot Temperature; In Vitro Techniques; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Mice; Narcotic Antagonists; Oligopeptides; Pain Measurement; Peptide Fragments; Reaction Time; Receptors, Opioid	2001