1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) has been researched along with naltrexone in 5 studies
| Studies (1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8)) | Trials (1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8)) | Recent Studies (post-2010) (1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8)) | Studies (naltrexone) | Trials (naltrexone) | Recent Studies (post-2010) (naltrexone) |
|---|---|---|---|---|---|
| 35 | 2 | 0 | 8,745 | 1,228 | 2,642 |
| Protein | Taxonomy | 1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) (IC50) | naltrexone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 1 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.0051 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0063 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.006 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.006 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.0319 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0093 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0377 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0076 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0004 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Furuya, Y; Kaneko, T; Nakazawa, T; Yamatsu, K | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Misawa, M; Nagase, H; Suzuki, T; Tsuda, M | 1 |
| Butelman, ER; Harris, TJ; Kreek, MJ | 1 |
| Ball, JW; Butelman, ER; Kreek, MJ | 1 |
5 other study(ies) available for 1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) and naltrexone
| Article | Year |
|---|---|
Spinal kappa receptor-mediated analgesia of E-2078, a systemically active dynorphin analog, in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Blockade of morphine reward through the activation of kappa-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Apomorphine; Conditioning, Operant; Dopamine; Dynorphins; Homovanillic Acid; Injections, Subcutaneous; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motivation; Naltrexone; Peptide Fragments; Prosencephalon; Pyrrolidines; Receptors, Opioid, kappa; Reward | 1993 |
Involvement of the opioid system in the anxiolytic effect of diazepam in mice.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Anticonvulsants; Body Temperature; Conflict, Psychological; Diazepam; Drug Interactions; Dynorphins; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa | 1996 |
Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys.
Topics: Animals; Azocines; Dose-Response Relationship, Drug; Dynorphins; Female; Hypnotics and Sedatives; Injections, Subcutaneous; Macaca mulatta; Male; Motor Activity; Muscle Relaxation; Naltrexone; Narcotic Antagonists; Peptide Fragments; Prolactin; Pyrrolidines; Receptors, Opioid, kappa; Time Factors | 1999 |
Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic kappa-opioid agonists in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Blood-Brain Barrier; Discrimination Learning; Dose-Response Relationship, Drug; Dynorphins; Female; Hypothalamus; Injections, Intravenous; Macaca mulatta; Male; Naltrexone; Neurosecretory Systems; Peptide Fragments; Prolactin; Pyrrolidines; Receptors, Opioid, kappa | 2004 |