1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) has been researched along with dynorphins in 33 studies
| Studies (1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8)) | Trials (1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8)) | Recent Studies (post-2010) (1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8)) | Studies (dynorphins) | Trials (dynorphins) | Recent Studies (post-2010) (dynorphins) |
|---|---|---|---|---|---|
| 35 | 2 | 0 | 3,096 | 24 | 514 |
| 35 | 2 | 0 | 368 | 4 | 15 |
| Protein | Taxonomy | 1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) (IC50) | dynorphins (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.0077 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0001 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.06) | 18.7374 |
| 1990's | 28 (84.85) | 18.2507 |
| 2000's | 3 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ohno, M; Ueki, S; Yamamoto, T | 1 |
| Huidobro-Toro, JP; López, LF; Roblero, JS; Salas, SP; Tachibana, S | 1 |
| Furuya, Y; Kaneko, T; Nakazawa, T; Yamatsu, K | 1 |
| Kaneko, T; Nakazawa, T; Yamanishi, Y | 1 |
| Deguchi, Y; Hirai, K; Sato, H; Terasaki, T; Tsuji, A | 1 |
| Goto, M; Kaneko, T; Nakazawa, T; Tachibana, S; Taki, T; Yamatsu, K; Yoshino, H | 1 |
| Donoso, MV; Huidobro-Toro, JP; López, LF; Pérez, A; Roblero, J; Tachibana, S | 1 |
| Furuya, Y; Kaneko, T; Nakazawa, T; Tachibana, S; Yamatsu, K; Yoshino, H | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T | 1 |
| Han, JS; Wang, XH; Wang, XJ | 2 |
| Asakawa, N; Kodama, M; Komeda, K; Niikawa, N; Nose, K; Tanase, T; Tsujii, M; Yamatsu, K; Yoshino, H | 1 |
| Herz, A; Shippenberg, TS; Spanagel, R | 1 |
| Hirota, K | 1 |
| Muraoka, M | 1 |
| Han, JS; Wang, XJ; Zhang, LJ | 1 |
| Hirai, K; Kang, YS; Sato, H; Terasaki, T; Tsuji, A | 1 |
| Kato, A; Koyama, N; Miyake, Y; Murahashi, N; Watanabe, S; Yuzuriha, T | 1 |
| Funada, M; Misawa, M; Nagase, H; Narita, M; Suzuki, T | 1 |
| Hasegawa, J; Mihara, M; Ohnishi, A; Tanaka, T; Tomono, Y; Yasuda, S | 1 |
| Chen, SZ; Han, JS | 1 |
| Ableitner, A; Bals-Kubik, R; Herz, A; Shippenberg, TS | 1 |
| Fujimoto, K; Momose, T | 1 |
| Misawa, M; Nagase, H; Suzuki, T; Tsuda, M | 1 |
| Butelman, ER; Chait, BT; Kreek, MJ; Woods, JH; Yu, J | 2 |
| Butelman, ER; Kreek, MJ; Vivian, JA; Woods, JH; Yu, J | 1 |
| Asai, Y; Watanabe, S | 1 |
| Butelman, ER; Harris, TJ; Kreek, MJ | 1 |
| Ambo, A; Hiramatsu, M; Inoue, K; Kameyama, T; Sasaki, Y | 1 |
| Ball, JW; Butelman, ER; Harris, TJ; Kreek, MJ | 1 |
| Ball, JW; Butelman, ER; Kreek, MJ | 1 |
| Akil, H; Goldstein, A; Mansour, A; Meng, F; Thompson, RC; Watson, SJ; Xie, GX | 1 |
2 trial(s) available for 1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) and dynorphins
| Article | Year |
|---|---|
Aquaretic effect of the stable dynorphin-A analog E2078 in the human.
Topics: Adult; Diuresis; Diuretics; Drug Administration Schedule; Dynorphins; Electrolytes; Humans; Male; Middle Aged; Osmolar Concentration; Peptide Fragments; Single-Blind Method; Urine; Vasopressins; Water | 1994 |
[Analgesic efficacy of E2078 (dynorphin analog) in patients following abdominal surgery].
Topics: Abdomen; Adult; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Dynorphins; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Pain, Postoperative; Pentazocine; Peptide Fragments | 1995 |
31 other study(ies) available for 1-n-me-tyr(1)-7-n-me-arg-8-n-et-leunh2-dynorphin (1-8) and dynorphins
| Article | Year |
|---|---|
Analgesic and discriminative stimulus properties of U-62,066E, the selective kappa-opioid receptor agonist, in the rat.
Topics: Analgesics; Animals; Benzomorphans; Cues; Discrimination, Psychological; Dopamine; Dopamine Antagonists; Dynorphins; Male; Morphine; Narcotic Antagonists; Peptide Fragments; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
[N-methyl-Tyr1,N-methyl-Arg7-D-Leu8]-dynorphin-A-(1-8)ethylamide, a stable dynorphin analog, produces diuresis by kappa-opiate receptor activation in the rat.
Topics: Animals; Diuresis; Diuretics; Dynorphins; Female; Kidney; Male; Narcotic Antagonists; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1992 |
Spinal kappa receptor-mediated analgesia of E-2078, a systemically active dynorphin analog, in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
A comparative study of monoaminergic involvement in the antinociceptive action of E-2078, morphine and U-50,488E.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Biogenic Monoamines; Drug Interactions; Dynorphins; Male; Mice; Morphine; Neurotoxins; Peptide Fragments; Pyrrolidines | 1991 |
In vivo transport of a dynorphin-like analgesic peptide, E-2078, through the blood-brain barrier: an application of brain microdialysis.
Topics: Amino Acid Sequence; Animals; Blood Volume; Blood-Brain Barrier; Brain Chemistry; Capillaries; Chromatography, High Pressure Liquid; Dialysis; Dynorphins; Endocytosis; Male; Molecular Sequence Data; Peptide Fragments; Perfusion; Rats; Rats, Inbred Strains; Tyrosine | 1991 |
Physical dependence liability of dynorphin A analogs in rodents.
Topics: Analgesics; Animals; Dynorphins; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
Diuretic profile of 66A-078, a synthetic non hydrolizable dynorphin derivative active centrally.
Topics: Amino Acid Sequence; Animals; Blood Pressure; Diuresis; Diuretics; Dynorphins; Hydrolysis; Molecular Sequence Data; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Analgesia produced by E-2078, a systemically active dynorphin analog, in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Buprenorphine; Drug Interactions; Dynorphins; Male; Mice; Morphine; Naloxone; Peptide Fragments; Pyrrolidines; Receptors, Opioid | 1990 |
Behavioral changes induced by stressful situations: effects of enkephalins, dynorphin, and their interactions.
Topics: Animals; Behavior, Animal; Drug Interactions; Dynorphins; Endorphins; Enkephalins; Male; Mice; Peptide Fragments; Physical Exertion; Stress, Physiological; Swimming | 1990 |
Cholecystokinin octapeptide antagonized opioid analgesia mediated by mu- and kappa- but not delta-receptors in the spinal cord of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Proglumide; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Spinal Cord | 1990 |
A large-scale synthesis of [MeTyr1, MeArg7, D-Leu8]dynorphin A-(1-8)-NHEt (E-2078) by application of the trifluoroacetic acid-pentamethylbenzene deprotecting procedure in the final stage.
Topics: Amino Acid Sequence; Dynorphins; Molecular Sequence Data; Peptide Fragments; Trifluoroacetic Acid | 1990 |
The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study.
Topics: Analgesics; Animals; Dialysis; Dopamine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Magnesium; Male; Nucleus Accumbens; Peptide Fragments; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin | 1990 |
[Effects of the dynorphin derivative "E2078" on hemodynamics and plasma catecholamines in dogs].
Topics: Analgesics; Animals; Catecholamines; Dogs; Dynorphins; Hemodynamics; Peptide Fragments | 1990 |
[Effects of E2078, a new dynorphin derivative, on pituitary-adrenocortical functions in dogs].
Topics: Analgesics; Animals; Dogs; Dynorphins; Peptide Fragments; Pituitary-Adrenal System | 1990 |
Phorbol ester suppression of opioid analgesia in rats.
Topics: Analgesia; Animals; Calcium; Cyclic AMP; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotic Antagonists; Peptide Fragments; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Spinal Cord; Tetradecanoylphorbol Acetate | 1990 |
[Cholecystokinin octapeptide (CCK-8) antagonized analgesia mediated by mu and kappa opioid receptors].
Topics: Analgesics; Animals; Dynorphins; Endorphins; Injections, Spinal; Male; Pain; Peptide Fragments; Proglumide; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Sincalide; Spinal Cord | 1990 |
Absorptive-mediated endocytosis of a dynorphin-like analgesic peptide, E-2078 into the blood-brain barrier.
Topics: Animals; Arsenicals; Blood-Brain Barrier; Brain; Capillaries; Cattle; Chromatography, High Pressure Liquid; Dynorphins; Endocytosis; In Vitro Techniques; Male; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains | 1989 |
Rectal absorption of E-2078 (dynorphin analogue peptide) in rats.
Topics: Administration, Oral; Administration, Rectal; Amino Acid Sequence; Analgesics; Animals; Biological Availability; Dynorphins; Hydrogen-Ion Concentration; Injections; Intestinal Absorption; Male; Molecular Sequence Data; Osmolar Concentration; Peptide Fragments; Rats; Rats, Inbred Strains; Viscosity | 1989 |
Blockade of morphine reward through the activation of kappa-opioid receptors in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Apomorphine; Conditioning, Operant; Dopamine; Dynorphins; Homovanillic Acid; Injections, Subcutaneous; Limbic System; Male; Mice; Mice, Inbred Strains; Morphine; Motivation; Naltrexone; Peptide Fragments; Prosencephalon; Pyrrolidines; Receptors, Opioid, kappa; Reward | 1993 |
[Cholecystokinin octapeptide antagonized the effect of NDAP on CaM in rat dorsal spinal synaptosome].
Topics: Animals; Calmodulin; Dynorphins; Female; Male; Peptide Fragments; Rats; Rats, Wistar; Sincalide; Spinal Cord; Synaptosomes | 1994 |
Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.
Topics: Amino Acid Sequence; Animals; Association Learning; Autoradiography; Brain Mapping; Conditioning, Operant; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamus, Middle; Injections, Intraventricular; Limbic System; Male; Microinjections; Molecular Sequence Data; Motivation; Narcotics; Nucleus Accumbens; Peptide Fragments; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substantia Nigra | 1993 |
Involvement of the opioid system in the anxiolytic effect of diazepam in mice.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Anticonvulsants; Body Temperature; Conflict, Psychological; Diazepam; Drug Interactions; Dynorphins; Male; Mice; Mice, Inbred Strains; Motor Activity; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa | 1996 |
Dynorphin A (1-8) analog, E-2078, is stable in human and rhesus monkey blood.
Topics: Adult; Analgesics, Non-Narcotic; Animals; Biotransformation; Dynorphins; Female; Humans; Macaca mulatta; Male; Peptide Fragments; Reference Standards; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1997 |
Dynorphin A (1-8) analog, E-2078, crosses the blood-brain barrier in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Animals; Biotransformation; Blood-Brain Barrier; Dynorphins; Erythrocyte Count; Female; Macaca mulatta; Male; Peptide Fragments; Reference Standards; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1997 |
Systemic effects of E-2078, a stabilized dynorphin A(1-8) analog, in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Conditioning, Operant; Discrimination, Psychological; Diuresis; Dynorphins; Ethylketocyclazocine; Female; Food; Injections, Intramuscular; Injections, Subcutaneous; Macaca mulatta; Male; Pain Measurement; Peptide Fragments; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
Effect of a Dynorphin A analog, E2078, on phospholipid membrane properties.
Topics: Dynorphins; Lipid Bilayers; Membrane Fluidity; Peptide Fragments; Permeability; Phosphatidylglycerols; Phospholipids; Temperature | 1999 |
Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys.
Topics: Animals; Azocines; Dose-Response Relationship, Drug; Dynorphins; Female; Hypnotics and Sedatives; Injections, Subcutaneous; Macaca mulatta; Male; Motor Activity; Muscle Relaxation; Naltrexone; Narcotic Antagonists; Peptide Fragments; Prolactin; Pyrrolidines; Receptors, Opioid, kappa; Time Factors | 1999 |
Long-lasting antinociceptive effects of a novel dynorphin analogue, Tyr-D-Ala-Phe-Leu-Arg psi (CH(2)NH) Arg-NH(2), in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Dynorphins; Guinea Pigs; Hot Temperature; In Vitro Techniques; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Mice; Narcotic Antagonists; Oligopeptides; Pain Measurement; Peptide Fragments; Reaction Time; Receptors, Opioid | 2001 |
Topical capsaicin-induced allodynia in unanesthetized primates: pharmacological modulation.
Topics: Aminobutyrates; Analgesics; Animals; Benzeneacetamides; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Dynorphins; Female; Ketamine; Macaca mulatta; Pain; Pain Measurement; Peptide Fragments; Pyrrolidines | 2003 |
Peripheral selectivity and apparent efficacy of dynorphins: comparison to non-peptidic kappa-opioid agonists in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Blood-Brain Barrier; Discrimination Learning; Dose-Response Relationship, Drug; Dynorphins; Female; Hypothalamus; Injections, Intravenous; Macaca mulatta; Male; Naltrexone; Neurosecretory Systems; Peptide Fragments; Prolactin; Pyrrolidines; Receptors, Opioid, kappa | 2004 |
Cloning and pharmacological characterization of a rat kappa opioid receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Cell Line; Cell Membrane; Cloning, Molecular; Corpus Striatum; Cyclic AMP; DNA Primers; DNA, Complementary; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Library; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; Molecular Sequence Data; Pyrrolidines; Rats; Receptors, Opioid, kappa; Restriction Mapping; RNA, Messenger; Transfection | 1993 |