1-monooleoyl-rac-glycerol and maltodextrin

1-monooleoyl-rac-glycerol has been researched along with maltodextrin* in 2 studies

Other Studies

2 other study(ies) available for 1-monooleoyl-rac-glycerol and maltodextrin

Article	Year
Resistant Maltodextrin Decreases Micellar Solubility of Lipids and Diffusion of Bile Salt Micelles and Suppresses Incorporation of Micellar Fatty Acids into Caco-2 Cells. Journal of nutritional science and vitaminology, 2016, Volume: 62, Issue:5 Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD. Incorporation of [1- Topics: Bile Acids and Salts; Caco-2 Cells; Cell Differentiation; Fatty Acids; Glycerides; Humans; Intestinal Absorption; Micelles; Oleic Acid; Phosphatidylcholines; Polysaccharides; Solubility; Triglycerides	2016
Characterization of naproxen-loaded solid SMEDDSs prepared by spray drying: the effect of the polysaccharide carrier and naproxen concentration. International journal of pharmaceutics, 2015, May-15, Volume: 485, Issue:1-2 The purpose of this study was to prepare solid SMEDDS (sSMEDDS) particles produced by spray-drying using maltodextrin (MD), hypromellose (HPMC), and a combination of the two as a solid carrier. Naproxen (NPX) as the model drug was dissolved (at 6% concentration) or partially suspended (at 18% concentration) in a liquid SMEDDS composed of Miglyol(®) 812, Peceol™, Gelucire(®) 44/14, and Solutol(®) HS 15. Among the sSMEDDSs tested, the MD-based sSMEDDSs (with a granular, smooth-surfaced, microspherical appearance) preserved the self-microemulsifying properties of liquid SMEDDSs and exhibited dissolution profiles similar to those of liquid SMEDDSs, irrespective of the concentration of NPX. In contrast, HPMC-based sSMEDDSs (irregular-shaped microparticles) exhibited slightly prolonged release times due to the polymeric nature of the carrier. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and Raman mapping analysis confirmed molecularly dissolved NPX (at 6% of drug loading), whereas at 18% NPX loading drug is partially molecularly dissolved and partially in the crystalline state. Topics: Aerosols; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Crystallography, X-Ray; Desiccation; Drug Carriers; Emulsions; Hypromellose Derivatives; Kinetics; Microscopy, Electron, Scanning; Naproxen; Oleic Acids; Particle Size; Polyethylene Glycols; Polysaccharides; Powder Diffraction; Solubility; Spectrum Analysis, Raman; Stearic Acids; Surface Properties; Technology, Pharmaceutical; Triglycerides	2015

Article

Year

Resistant Maltodextrin Decreases Micellar Solubility of Lipids and Diffusion of Bile Salt Micelles and Suppresses Incorporation of Micellar Fatty Acids into Caco-2 Cells.

Journal of nutritional science and vitaminology, 2016, Volume: 62, Issue:5

Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD. Incorporation of [1-

Topics: Bile Acids and Salts; Caco-2 Cells; Cell Differentiation; Fatty Acids; Glycerides; Humans; Intestinal Absorption; Micelles; Oleic Acid; Phosphatidylcholines; Polysaccharides; Solubility; Triglycerides

2016

Characterization of naproxen-loaded solid SMEDDSs prepared by spray drying: the effect of the polysaccharide carrier and naproxen concentration.

International journal of pharmaceutics, 2015, May-15, Volume: 485, Issue:1-2

The purpose of this study was to prepare solid SMEDDS (sSMEDDS) particles produced by spray-drying using maltodextrin (MD), hypromellose (HPMC), and a combination of the two as a solid carrier. Naproxen (NPX) as the model drug was dissolved (at 6% concentration) or partially suspended (at 18% concentration) in a liquid SMEDDS composed of Miglyol(®) 812, Peceol™, Gelucire(®) 44/14, and Solutol(®) HS 15. Among the sSMEDDSs tested, the MD-based sSMEDDSs (with a granular, smooth-surfaced, microspherical appearance) preserved the self-microemulsifying properties of liquid SMEDDSs and exhibited dissolution profiles similar to those of liquid SMEDDSs, irrespective of the concentration of NPX. In contrast, HPMC-based sSMEDDSs (irregular-shaped microparticles) exhibited slightly prolonged release times due to the polymeric nature of the carrier. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and Raman mapping analysis confirmed molecularly dissolved NPX (at 6% of drug loading), whereas at 18% NPX loading drug is partially molecularly dissolved and partially in the crystalline state.

Topics: Aerosols; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Crystallography, X-Ray; Desiccation; Drug Carriers; Emulsions; Hypromellose Derivatives; Kinetics; Microscopy, Electron, Scanning; Naproxen; Oleic Acids; Particle Size; Polyethylene Glycols; Polysaccharides; Powder Diffraction; Solubility; Spectrum Analysis, Raman; Stearic Acids; Surface Properties; Technology, Pharmaceutical; Triglycerides

2015