Page last updated: 2024-08-25

1-methylxanthine and uric acid

1-methylxanthine has been researched along with uric acid in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (4.88)	18.7374
1990's	17 (41.46)	18.2507
2000's	13 (31.71)	29.6817
2010's	9 (21.95)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cameron, IL; Lyles, MB; Rawls, HR	1
Birkett, DJ; Day, RO; Miners, JO	1
Kalow, W; Tang, BK	1
Karnes, HT; Sarkar, MA	1
Iriah, J; Kadar, D; Kalow, W; Qian, L; Tang, BK; Yip, J	1
Beitins, IZ; Kilbane, AJ; Manis, M; Silbart, LK; Weber, WW	1
Guzelian, PS; Hunt, C; Karnes, HT; Polk, RE; Sarkar, M	1
Birkett, DJ; Gregor, D; McManus, ME; Miners, JO; Stupans, I	1
Campbell, ME; Kalow, W; Spielberg, SP	1
Aarons, L; Davis, JD; Houston, JB	1
Chen, J; Follath, F; Freiburghaus, AU; Ha, HR	1
Brøsen, K; Nielsen, KK; Rasmussen, BB	1
Galteau, MM; Gueguen, R; Pontes, ZB; Siest, G; Vincent-Viry, M	1
Iga, T; Kawakami, J; Sawada, Y; Toyama, E; Yamamoto, K	1
Birkett, DJ; Day, RO; Lillywhite, KJ; Miners, JO; Valente, L	1
Norman, A; Rodopoulos, N	1
Bernal, ML; Fanlo, A; Juste, JL; Lanuza, J; Mayayo, E; Sáenz, MA; Sinués, B	1
Cao, W; Chen, G; Ling, SS; Zhuo, HT	1
Cao, XM; Ling, SS; Lu, JF; Yi, T; Zhuo, HT	1
Cao, XM; Lin, SS; Lu, JF; Yi, T; Zhuo, HT	1
Barrett, EJ; Clark, AD; Clark, MG; Dawson, D; Lindner, JR; Rattigan, S; Vincent, MA	1
Crews, HM; Olivier, L; Wilson, LA	1
Abraham, K; Bauer, S; Brockmöller, J; Geusau, A; Helge, H; Tosun, Y	1
Borlak, J; Cascorbi, I; Erb, K; Fuhr, U; Hermann, R; Illauer, M; Jetter, A; Kinzig-Schippers, M; Smith, G; Sörgel, F; Wolf, H	1
Kim, JQ; Park, HD; Park, KU; Song, J; Yoon, Y	1
Li, J; Peng, XQ; Xu, JP; Zhang, J	1
Brüning, T; John, A; Rihs, HP; Scherenberg, M; Seidel, A	1
Brøsen, K; Damkier, P; Grandjean, P; Halling, J; Nielsen, F; Petersen, MS; Weihe, P	1
Asprodini, EK; Begas, E; Kouvaras, E; Papakosta, S; Tsakalof, A	1
Fuhr, U; Jetter, A; Kinzig, M; Rodamer, M; Sörgel, F; Tomalik-Scharte, D	1
Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Summers, R; Yu, CL	1
Ashida, H; Hashimoto, T; Kanazawa, K; Nakabayashi, H; Nishiumi, S	1
Aklillu, E; Carrillo, JA; Djordjevic, N; Fukasawa, T; Gervasini, G; Jankovic, S; Suda, A; Ueda, N	1
Aklillu, E; Bertilsson, L; Carrillo, JA; Djordjevic, N; Karlsson, S; Roh, HK; Ueda, N	1
Chae, JW; Kim, DH; Kim, Ej; Kwon, KI; Lee, BY	1
Kamataki, T; Kimura, M; Kiyotani, K; Nakagawa, K; Shimizu, M; Yamazaki, H	1
Fan, XR; Li, XY; Li, YF; Li, YP; Liu, YN; Yang, M; Yao, XC; Yin, YM; Yuan, M; Zhu, JB	1
Ahluwalia, N; Pao, CI; Pfeiffer, CM; Rybak, ME; Sternberg, MR	1
Kishimoto, I; Kobayashi, K; Murayama, N; Shimizu, M; Yamazaki, H	1
Aklillu, E; Bertilsson, L; Carrillo, JA; Djordjevic, N; Makonnen, E	1
Dong, ZB; Liang, YR; Lu, J; Ma, YX; Wu, HS; Wu, XH; Ye, JH; Zheng, XQ	1

Trials

2 trial(s) available for 1-methylxanthine and uric acid

Article	Year
Urinary biomarkers for assessing dietary exposure to caffeine. Food additives and contaminants, 2001, Volume: 18, Issue:12 Topics: Adult; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Diet; Female; Humans; Liver; Male; Middle Aged; Phenotype; Theophylline; Time Factors; Uric Acid; Xanthines	2001
Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers. Drug metabolism letters, 2012, Jun-01, Volume: 6, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genotype; Humans; Japan; Male; Phenotype; Pilot Projects; Theophylline; Uric Acid; Xanthines; Young Adult	2012

Other Studies

39 other study(ies) available for 1-methylxanthine and uric acid

Article	Year
Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange. Journal of medicinal chemistry, 2001, Dec-20, Volume: 44, Issue:26 Topics: Acridine Orange; Intercalating Agents; Methylation; Nonlinear Dynamics; Spectrophotometry; Structure-Activity Relationship; Xanthines	2001
1-Methylxanthine derived from theophylline as an in vivo biochemical probe of allopurinol effect. British journal of clinical pharmacology, 1991, Volume: 32, Issue:2 Topics: Adult; Allopurinol; Biomarkers; Female; Humans; Male; Oxypurinol; Theophylline; Uric Acid; Xanthines	1991
Caffeine as a metabolic probe: exploration of the enzyme-inducing effect of cigarette smoking. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:1 Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Liver; Nicotiana; Oxidoreductases; Plants, Toxic; Smoking; Uric Acid; Xanthines	1991
High performance liquid chromatographic determination of theophylline metabolites in human liver microsomes. Biomedical chromatography : BMC, 1991, Volume: 5, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Microchemistry; Microsomes, Liver; Quality Control; Uric Acid; Xanthines	1991
Caffeine as a metabolic probe: validation of its use for acetylator phenotyping. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:6 Topics: Acetylation; Acetyltransferases; Adult; Caffeine; Humans; Phenotype; Polymorphism, Genetic; Sulfamethazine; Time Factors; Uracil; Uric Acid; Xanthines	1991
Human N-acetylation genotype determination with urinary caffeine metabolites. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4 Topics: Acetylation; Caffeine; Chromatography, High Pressure Liquid; Gene Frequency; Genetics, Population; Genotype; Humans; Nitrogen; Pedigree; Phenotype; Theophylline; Time Factors; Uracil; Uric Acid; Xanthines	1990
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:4 Topics: Biotransformation; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Hydroxylation; Microsomes, Liver; Norfloxacin; Theophylline; Uric Acid; Xanthines	1990
Theophylline metabolism by human, rabbit and rat liver microsomes and by purified forms of cytochrome P450. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:6 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Theophylline; Uric Acid; Xanthines	1988
A urinary metabolite ratio that reflects systemic caffeine clearance. Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:2 Topics: Adult; Age Factors; Asian People; Caffeine; Child; Child, Preschool; Contraceptives, Oral; Cytochrome P-450 Enzyme System; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Smoking; Time Factors; Uracil; Uric Acid; White People; Xanthines	1987
Metabolism of theophylline and its inhibition by fluoroquinolones in rat hepatic microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:6 Topics: Animals; Anti-Infective Agents; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Enoxacin; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Xanthines	1995
Metabolism of theophylline by cDNA-expressed human cytochromes P-450. British journal of clinical pharmacology, 1995, Volume: 39, Issue:3 Topics: Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Induction; Epoxide Hydrolases; Humans; Hydroxylation; Isoenzymes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Smoking; Theophylline; Tumor Cells, Cultured; Uric Acid; Xanthines	1995
Determination of theophylline metabolites in human liver microsomes by high-performance liquid chromatography. Analytical biochemistry, 1994, Volume: 222, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Microsomes, Liver; Reproducibility of Results; Spectrophotometry, Ultraviolet; Uric Acid; Xanthines	1994
Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes. Genetic epidemiology, 1994, Volume: 11, Issue:2 Topics: Acetylation; Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; Caffeine; Child; Chromatography, High Pressure Liquid; Family; Female; Gene Frequency; Genes, Recessive; Humans; Male; Middle Aged; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Genetic; Theophylline; Uracil; Uric Acid; Xanthines	1994
Neurotoxic convulsions induced by theophylline and its metabolites in mice. Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:6 Topics: Animals; Blood-Brain Barrier; Brain; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; Neurotoxins; Seizures; Theophylline; Uric Acid; Xanthines	1996
1-Methylxanthine derived from caffeine as a pharmacodynamic probe of oxypurinol effect. British journal of clinical pharmacology, 1997, Volume: 43, Issue:2 Topics: Adult; Caffeine; Female; Humans; Male; Molecular Probes; Oxypurinol; Uric Acid; Xanthines	1997
Elimination of theophylline metabolites in healthy adults. Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:3 Topics: Administration, Oral; Adult; Female; Humans; Male; Middle Aged; Theophylline; Time Factors; Uric Acid; Xanthines	1997
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:2 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Environmental Exposure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutagens; Rheology; Smoking; Theophylline; Time Factors; Uracil; Uric Acid; Urination; Xanthines	1999
Pharmacokinetics of theophylline metabolites in 8 Chinese patients. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:5 Topics: Adult; Aminophylline; Asthma; Bronchodilator Agents; Circadian Rhythm; Humans; Middle Aged; Theophylline; Uric Acid; Xanthines	1998
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:11 Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	1997
[HPLC determination of five caffeine metabolites]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:8 Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Uracil; Uric Acid; Xanthines	1997
Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow. Diabetes, 2002, Volume: 51, Issue:1 Topics: Animals; Biotransformation; Capillaries; Hindlimb; Hyperinsulinism; Infusions, Intravenous; Insulin; Kinetics; Male; Microcirculation; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Uric Acid; Xanthine Oxidase; Xanthines	2002
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2 Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines	2002
Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure. European journal of clinical pharmacology, 2004, Volume: 60, Issue:1 Topics: Acetylation; Administration, Oral; Adult; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Diet; Female; Genotype; Humans; Male; Middle Aged; Phenotype; Spectrometry, Mass, Electrospray Ionization; Time Factors; Uracil; Uric Acid; Xanthines	2004
High-throughput liquid chromatography-tandem mass spectrometry assay for plasma theophylline and its metabolites. Clinical chemistry, 2004, Volume: 50, Issue:11 Topics: Bronchodilator Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Plasma; Theophylline; Uric Acid; Xanthines	2004
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:3 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Theophylline; Uracil; Uric Acid; Xanthines	2006
Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay. Clinica chimica acta; international journal of clinical chemistry, 2007, Volume: 376, Issue:1-2 Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Biotransformation; Caffeine; Genotype; Humans; Male; Middle Aged; Phenotype; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Uracil; Uric Acid; White People; Xanthines	2007
Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls. European journal of clinical pharmacology, 2006, Volume: 62, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Biometry; Caffeine; Cohort Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Female; Genotype; Humans; Male; Methylation; Middle Aged; Polychlorinated Biphenyls; Sex Factors; Smoking; Uracil; Uric Acid; Xanthines	2006
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomedical chromatography : BMC, 2007, Volume: 21, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	2007
Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected? European journal of clinical pharmacology, 2009, Volume: 65, Issue:4 Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Humans; Male; Phenotype; Time Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines	2009
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5. Journal of bacteriology, 2009, Volume: 191, Issue:14 Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2009
Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes. BioFactors (Oxford, England), 2008, Volume: 34, Issue:4 Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Biological Transport; Caffeine; Cell Differentiation; Glucose; Insulin; Lipid Metabolism; Mice; Theophylline; Uracil; Uric Acid; Xanthines	2008
N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population. Journal of clinical pharmacology, 2011, Volume: 51, Issue:7 Topics: Acetylation; Adolescent; Adult; Arylamine N-Acetyltransferase; Caffeine; Female; Genetic Association Studies; Haplotypes; Humans; Isoenzymes; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Serbia; Uracil; Uric Acid; White People; Xanthines; Young Adult	2011
Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans. Journal of clinical pharmacology, 2012, Volume: 52, Issue:10 Topics: Arylamine N-Acetyltransferase; Asian People; Caffeine; Contraceptives, Oral; Genotype; Humans; Phenotype; Polymorphism, Single Nucleotide; Sex Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines	2012
Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Mar-15, Volume: 889-890 Topics: Animals; Chromatography, Liquid; Drug Stability; Least-Squares Analysis; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2012
[Effect of Tibetan medicine zuotai on the activity, protein and mRNA expression of CYP1A2 and NAT2]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:2 Topics: Administration, Oral; Animals; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Male; Medicine, Tibetan Traditional; Rats; Rats, Sprague-Dawley; RNA, Messenger; Theophylline; Uracil; Uric Acid; Xanthines	2014
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake. The Journal of nutrition, 2015, Volume: 145, Issue:4 Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult	2015
Cytochrome P450 2A6 Phenotyping Using Dietary Caffeine Salivary Metabolite Ratios and Genotyping Using Blood on Storage Cards in Non-smoking Japanese Volunteers. Drug metabolism letters, 2017, Volume: 10, Issue:4 Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Diet; Female; Genotyping Techniques; Healthy Volunteers; Humans; Male; Middle Aged; Multiplex Polymerase Chain Reaction; Phenotype; Real-Time Polymerase Chain Reaction; Saliva; Specimen Handling; Tea; Uric Acid; Xanthines	2017
N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians. European journal of clinical pharmacology, 2018, Volume: 74, Issue:7 Topics: Adult; Arylamine N-Acetyltransferase; Black People; Caffeine; Ethiopia; Female; Gene-Environment Interaction; Genotype; Humans; Male; Phenotype; Polymorphism, Single Nucleotide; Sweden; Uracil; Uric Acid; Xanthines	2018
Different Catabolism Pathways Triggered by Various Methylxanthines in Caffeine-Tolerant Bacterium Journal of microbiology and biotechnology, 2018, Jul-28, Volume: 28, Issue:7 Topics: Biodegradation, Environmental; Caffeine; Drug Tolerance; Gardens; Metabolic Networks and Pathways; Pseudomonas putida; Soil; Soil Microbiology; Substrate Specificity; Tea; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2018