Page last updated: 2024-08-25

1-methylxanthine and theophylline

1-methylxanthine has been researched along with theophylline in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (7.69)	18.7374
1990's	19 (48.72)	18.2507
2000's	11 (28.21)	29.6817
2010's	6 (15.38)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hasegawa, T; Iwasaki, N; Kakiuchi, M; Kato, H; Konno, K; Miyamoto, K; Sakai, R; Sanae, F; Takagi, K; Yamamoto, Y	1
Daly, JW; Padgett, WL; Shamim, MT; Ukena, D	1
Abdallah, AH; Daly, JW; Dickerson, GA; Peet, NP; Ukena, D	1
Grahner, B; Lanzner, W; Müller, CE; Winiwarter, S	1
Daly, JW; Manning, M; Müller, CE; Shi, D	1
Cameron, IL; Lyles, MB; Rawls, HR	1
Gottehrer, A; Vaughan, LM	1
Birkett, DJ; Day, RO; Miners, JO	1
Kiss, T; Osipenko, ON	1
Beitins, IZ; Kilbane, AJ; Manis, M; Silbart, LK; Weber, WW	1
Guzelian, PS; Hunt, C; Karnes, HT; Polk, RE; Sarkar, M	1
Butler, MA; Kadlubar, FF; Lang, NP; Massengill, JP; Talaska, G; Teitel, CH	1
Birkett, DJ; Gregor, D; McManus, ME; Miners, JO; Stupans, I	1
Aarons, L; Davis, JD; Houston, JB	1
Chen, J; Follath, F; Freiburghaus, AU; Ha, HR	1
Bresnick, E; McQuilkin, SH; Nierenberg, DW	1
Galteau, MM; Gueguen, R; Pontes, ZB; Siest, G; Vincent-Viry, M	1
Iga, T; Kawakami, J; Sawada, Y; Toyama, E; Yamamoto, K	1
Norman, A; Rodopoulos, N	1
Bernal, ML; Fanlo, A; Juste, JL; Lanuza, J; Mayayo, E; Sáenz, MA; Sinués, B	1
Cao, W; Chen, G; Ling, SS; Zhuo, HT	1
Boobis, AR; Edwards, RJ; Murray, BP; Murray, S; Odupitan, AO	1
Cao, XM; Ling, SS; Lu, JF; Yi, T; Zhuo, HT	1
Cao, XM; Lin, SS; Lu, JF; Yi, T; Zhuo, HT	1
Barrett, E; Coggins, M; Fasy, E; Jahn, L; Kaul, S; Lindner, J; Rattigan, S	1
Crews, HM; Olivier, L; Wilson, LA	1
Abraham, K; Bauer, S; Brockmöller, J; Geusau, A; Helge, H; Tosun, Y	1
Cihlar, T; Haefeli, WE; Lindenmaier, H; Rengelshausen, J; Walter-Sack, I; Weiss, J	1
Kim, JQ; Park, HD; Park, KU; Song, J; Yoon, Y	1
Li, J; Peng, XQ; Xu, JP; Zhang, J	1
Asprodini, EK; Begas, E; Kouvaras, E; Papakosta, S; Tsakalof, A	1
Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Summers, R; Yu, CL	1
Ashida, H; Hashimoto, T; Kanazawa, K; Nakabayashi, H; Nishiumi, S	1
Justino, GC; Santos, PM; Silva, SA; Vieira, AJ	1
Chae, JW; Kim, DH; Kim, Ej; Kwon, KI; Lee, BY	1
Kamataki, T; Kimura, M; Kiyotani, K; Nakagawa, K; Shimizu, M; Yamazaki, H	1
Fan, XR; Li, XY; Li, YF; Li, YP; Liu, YN; Yang, M; Yao, XC; Yin, YM; Yuan, M; Zhu, JB	1
Ahluwalia, N; Pao, CI; Pfeiffer, CM; Rybak, ME; Sternberg, MR	1
Dong, ZB; Liang, YR; Lu, J; Ma, YX; Wu, HS; Wu, XH; Ye, JH; Zheng, XQ	1

Reviews

1 review(s) available for 1-methylxanthine and theophylline

Article	Year
Effect of xanthine-related compounds on a theophylline assay using theophylline oxidase. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:12 Topics: Allopurinol; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Oxidoreductases; Oxypurinol; Pentoxifylline; Theophylline; Xanthines	1992

Trials

2 trial(s) available for 1-methylxanthine and theophylline

Article	Year
Urinary biomarkers for assessing dietary exposure to caffeine. Food additives and contaminants, 2001, Volume: 18, Issue:12 Topics: Adult; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Diet; Female; Humans; Liver; Male; Middle Aged; Phenotype; Theophylline; Time Factors; Uric Acid; Xanthines	2001
Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers. Drug metabolism letters, 2012, Jun-01, Volume: 6, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genotype; Humans; Japan; Male; Phenotype; Pilot Projects; Theophylline; Uric Acid; Xanthines; Young Adult	2012

Other Studies

36 other study(ies) available for 1-methylxanthine and theophylline

Article	Year
Effects of alkyl substitutions of xanthine skeleton on bronchodilation. Journal of medicinal chemistry, 1992, Oct-30, Volume: 35, Issue:22 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Animals; Bronchodilator Agents; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Organ Specificity; Receptors, Purinergic; Structure-Activity Relationship; Trachea; Xanthines	1992
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines	1989
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. Journal of medicinal chemistry, 1988, Volume: 31, Issue:10 Topics: Adenosine; Animals; Bronchi; Guinea Pigs; Humans; Muscle Contraction; Pyrazoles; Rats; Receptors, Purinergic; Structure-Activity Relationship	1988
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists. Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10 Topics: Animals; Brain; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Xanthines	1994
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: Animals; Brain; Radioligand Assay; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theophylline; Xanthines	1993
Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange. Journal of medicinal chemistry, 2001, Dec-20, Volume: 44, Issue:26 Topics: Acridine Orange; Intercalating Agents; Methylation; Nonlinear Dynamics; Spectrophotometry; Structure-Activity Relationship; Xanthines	2001
1-Methylxanthine derived from theophylline as an in vivo biochemical probe of allopurinol effect. British journal of clinical pharmacology, 1991, Volume: 32, Issue:2 Topics: Adult; Allopurinol; Biomarkers; Female; Humans; Male; Oxypurinol; Theophylline; Uric Acid; Xanthines	1991
Neurohypophysial peptides selectively depressed high voltage-activated Ca-current in snail neurons. Neuroscience letters, 1990, Nov-27, Volume: 120, Issue:1 Topics: Animals; Barium; Caffeine; Calcium Channels; Ganglia; Helix, Snails; In Vitro Techniques; Lypressin; Membrane Potentials; Neurons; Oxytocin; Phosphodiesterase Inhibitors; Theophylline; Xanthines	1990
Human N-acetylation genotype determination with urinary caffeine metabolites. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4 Topics: Acetylation; Caffeine; Chromatography, High Pressure Liquid; Gene Frequency; Genetics, Population; Genotype; Humans; Nitrogen; Pedigree; Phenotype; Theophylline; Time Factors; Uracil; Uric Acid; Xanthines	1990
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:4 Topics: Biotransformation; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Hydroxylation; Microsomes, Liver; Norfloxacin; Theophylline; Uric Acid; Xanthines	1990
Determination of carcinogenic arylamine N-oxidation phenotype in humans by analysis of caffeine urinary metabolites. Progress in clinical and biological research, 1990, Volume: 340B Topics: Acetylation; Arylamine N-Acetyltransferase; Biotransformation; Caffeine; Cytochrome P-450 Enzyme System; Disease Susceptibility; Humans; Isoenzymes; Oxidation-Reduction; Phenotype; Theophylline; Uracil; Urinary Bladder Neoplasms; Xanthines	1990
Theophylline metabolism by human, rabbit and rat liver microsomes and by purified forms of cytochrome P450. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:6 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Theophylline; Uric Acid; Xanthines	1988
Metabolism of theophylline and its inhibition by fluoroquinolones in rat hepatic microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:6 Topics: Animals; Anti-Infective Agents; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Enoxacin; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Xanthines	1995
Metabolism of theophylline by cDNA-expressed human cytochromes P-450. British journal of clinical pharmacology, 1995, Volume: 39, Issue:3 Topics: Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Induction; Epoxide Hydrolases; Humans; Hydroxylation; Isoenzymes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Smoking; Theophylline; Tumor Cells, Cultured; Uric Acid; Xanthines	1995
Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1995, Volume: 4, Issue:2 Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Genetic Variation; Humans; Male; Middle Aged; Oxidoreductases; Phenotype; Spectrophotometry, Ultraviolet; Theophylline; Time Factors; Uracil; Xanthines	1995
Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes. Genetic epidemiology, 1994, Volume: 11, Issue:2 Topics: Acetylation; Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; Caffeine; Child; Chromatography, High Pressure Liquid; Family; Female; Gene Frequency; Genes, Recessive; Humans; Male; Middle Aged; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Genetic; Theophylline; Uracil; Uric Acid; Xanthines	1994
Neurotoxic convulsions induced by theophylline and its metabolites in mice. Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:6 Topics: Animals; Blood-Brain Barrier; Brain; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; Neurotoxins; Seizures; Theophylline; Uric Acid; Xanthines	1996
Elimination of theophylline metabolites in healthy adults. Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:3 Topics: Administration, Oral; Adult; Female; Humans; Male; Middle Aged; Theophylline; Time Factors; Uric Acid; Xanthines	1997
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:2 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Environmental Exposure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutagens; Rheology; Smoking; Theophylline; Time Factors; Uracil; Uric Acid; Urination; Xanthines	1999
Pharmacokinetics of theophylline metabolites in 8 Chinese patients. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:5 Topics: Adult; Aminophylline; Asthma; Bronchodilator Agents; Circadian Rhythm; Humans; Middle Aged; Theophylline; Uric Acid; Xanthines	1998
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:3 Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Inhibitory Concentration 50; Kinetics; Magnesium Chloride; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; Pentoxifylline; Phenacetin; Protein Binding; Serum Albumin; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Theophylline; Time Factors; Tromethamine; Xanthines	2001
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:11 Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	1997
[HPLC determination of five caffeine metabolites]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:8 Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Uracil; Uric Acid; Xanthines	1997
Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. Diabetes, 2001, Volume: 50, Issue:12 Topics: Adult; Albumins; Blood Flow Velocity; Blood Glucose; Blood Volume; Brachial Artery; Caffeine; Capillaries; Female; Glucose; Humans; Insulin; Lactic Acid; Male; Muscle, Skeletal; Oxygen Consumption; Theophylline; Xanthines	2001
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2 Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines	2002
Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine. Biochemical and biophysical research communications, 2004, Jul-16, Volume: 320, Issue:1 Topics: Animals; Caffeine; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Fluoresceins; Humans; Organic Anion Transporters; Theophylline; Xanthines	2004
High-throughput liquid chromatography-tandem mass spectrometry assay for plasma theophylline and its metabolites. Clinical chemistry, 2004, Volume: 50, Issue:11 Topics: Bronchodilator Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Plasma; Theophylline; Uric Acid; Xanthines	2004
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:3 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Theophylline; Uracil; Uric Acid; Xanthines	2006
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomedical chromatography : BMC, 2007, Volume: 21, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	2007
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5. Journal of bacteriology, 2009, Volume: 191, Issue:14 Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2009
Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes. BioFactors (Oxford, England), 2008, Volume: 34, Issue:4 Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Biological Transport; Caffeine; Cell Differentiation; Glucose; Insulin; Lipid Metabolism; Mice; Theophylline; Uracil; Uric Acid; Xanthines	2008
Demethylation of theophylline (1,3-dimethylxanthine) to 1-methylxanthine: the first step of an antioxidising cascade. Redox report : communications in free radical research, 2010, Volume: 15, Issue:3 Topics: Antioxidants; Free Radicals; Molecular Structure; Oxidative Stress; Phosphodiesterase Inhibitors; Signal Transduction; Theophylline; Xanthines	2010
Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Mar-15, Volume: 889-890 Topics: Animals; Chromatography, Liquid; Drug Stability; Least-Squares Analysis; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2012
[Effect of Tibetan medicine zuotai on the activity, protein and mRNA expression of CYP1A2 and NAT2]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:2 Topics: Administration, Oral; Animals; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Male; Medicine, Tibetan Traditional; Rats; Rats, Sprague-Dawley; RNA, Messenger; Theophylline; Uracil; Uric Acid; Xanthines	2014
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake. The Journal of nutrition, 2015, Volume: 145, Issue:4 Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult	2015
Different Catabolism Pathways Triggered by Various Methylxanthines in Caffeine-Tolerant Bacterium Journal of microbiology and biotechnology, 2018, Jul-28, Volume: 28, Issue:7 Topics: Biodegradation, Environmental; Caffeine; Drug Tolerance; Gardens; Metabolic Networks and Pathways; Pseudomonas putida; Soil; Soil Microbiology; Substrate Specificity; Tea; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2018