Page last updated: 2024-08-25

1-methyluric acid and 1-methylxanthine

1-methyluric acid has been researched along with 1-methylxanthine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.70)18.7374
1990's10 (37.04)18.2507
2000's10 (37.04)29.6817
2010's6 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Birkett, DJ; Day, RO; Miners, JO1
Iriah, J; Kadar, D; Kalow, W; Qian, L; Tang, BK; Yip, J1
Beitins, IZ; Kilbane, AJ; Manis, M; Silbart, LK; Weber, WW1
Campbell, ME; Kalow, W; Spielberg, SP1
Galteau, MM; Gueguen, R; Pontes, ZB; Siest, G; Vincent-Viry, M1
Birkett, DJ; Day, RO; Lillywhite, KJ; Miners, JO; Valente, L1
Norman, A; Rodopoulos, N1
Bernal, ML; Fanlo, A; Juste, JL; Lanuza, J; Mayayo, E; Sáenz, MA; Sinués, B1
Cao, W; Chen, G; Ling, SS; Zhuo, HT1
Cao, XM; Ling, SS; Lu, JF; Yi, T; Zhuo, HT1
Cao, XM; Lin, SS; Lu, JF; Yi, T; Zhuo, HT1
Barrett, EJ; Clark, AD; Clark, MG; Dawson, D; Lindner, JR; Rattigan, S; Vincent, MA1
Abraham, K; Bauer, S; Brockmöller, J; Geusau, A; Helge, H; Tosun, Y1
Borlak, J; Cascorbi, I; Erb, K; Fuhr, U; Hermann, R; Illauer, M; Jetter, A; Kinzig-Schippers, M; Smith, G; Sörgel, F; Wolf, H1
Kim, JQ; Park, HD; Park, KU; Song, J; Yoon, Y1
Li, J; Peng, XQ; Xu, JP; Zhang, J1
Brüning, T; John, A; Rihs, HP; Scherenberg, M; Seidel, A1
Brøsen, K; Damkier, P; Grandjean, P; Halling, J; Nielsen, F; Petersen, MS; Weihe, P1
Asprodini, EK; Begas, E; Kouvaras, E; Papakosta, S; Tsakalof, A1
Fuhr, U; Jetter, A; Kinzig, M; Rodamer, M; Sörgel, F; Tomalik-Scharte, D1
Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Summers, R; Yu, CL1
Aklillu, E; Carrillo, JA; Djordjevic, N; Fukasawa, T; Gervasini, G; Jankovic, S; Suda, A; Ueda, N1
Aklillu, E; Bertilsson, L; Carrillo, JA; Djordjevic, N; Karlsson, S; Roh, HK; Ueda, N1
Chae, JW; Kim, DH; Kim, Ej; Kwon, KI; Lee, BY1
Fan, XR; Li, XY; Li, YF; Li, YP; Liu, YN; Yang, M; Yao, XC; Yin, YM; Yuan, M; Zhu, JB1
Ahluwalia, N; Pao, CI; Pfeiffer, CM; Rybak, ME; Sternberg, MR1
Aklillu, E; Bertilsson, L; Carrillo, JA; Djordjevic, N; Makonnen, E1

Other Studies

27 other study(ies) available for 1-methyluric acid and 1-methylxanthine

ArticleYear
1-Methylxanthine derived from theophylline as an in vivo biochemical probe of allopurinol effect.
    British journal of clinical pharmacology, 1991, Volume: 32, Issue:2

    Topics: Adult; Allopurinol; Biomarkers; Female; Humans; Male; Oxypurinol; Theophylline; Uric Acid; Xanthines

1991
Caffeine as a metabolic probe: validation of its use for acetylator phenotyping.
    Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:6

    Topics: Acetylation; Acetyltransferases; Adult; Caffeine; Humans; Phenotype; Polymorphism, Genetic; Sulfamethazine; Time Factors; Uracil; Uric Acid; Xanthines

1991
Human N-acetylation genotype determination with urinary caffeine metabolites.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4

    Topics: Acetylation; Caffeine; Chromatography, High Pressure Liquid; Gene Frequency; Genetics, Population; Genotype; Humans; Nitrogen; Pedigree; Phenotype; Theophylline; Time Factors; Uracil; Uric Acid; Xanthines

1990
A urinary metabolite ratio that reflects systemic caffeine clearance.
    Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:2

    Topics: Adult; Age Factors; Asian People; Caffeine; Child; Child, Preschool; Contraceptives, Oral; Cytochrome P-450 Enzyme System; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Smoking; Time Factors; Uracil; Uric Acid; White People; Xanthines

1987
Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes.
    Genetic epidemiology, 1994, Volume: 11, Issue:2

    Topics: Acetylation; Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; Caffeine; Child; Chromatography, High Pressure Liquid; Family; Female; Gene Frequency; Genes, Recessive; Humans; Male; Middle Aged; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Genetic; Theophylline; Uracil; Uric Acid; Xanthines

1994
1-Methylxanthine derived from caffeine as a pharmacodynamic probe of oxypurinol effect.
    British journal of clinical pharmacology, 1997, Volume: 43, Issue:2

    Topics: Adult; Caffeine; Female; Humans; Male; Molecular Probes; Oxypurinol; Uric Acid; Xanthines

1997
Elimination of theophylline metabolites in healthy adults.
    Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:3

    Topics: Administration, Oral; Adult; Female; Humans; Male; Middle Aged; Theophylline; Time Factors; Uric Acid; Xanthines

1997
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Environmental Exposure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutagens; Rheology; Smoking; Theophylline; Time Factors; Uracil; Uric Acid; Urination; Xanthines

1999
Pharmacokinetics of theophylline metabolites in 8 Chinese patients.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:5

    Topics: Adult; Aminophylline; Asthma; Bronchodilator Agents; Circadian Rhythm; Humans; Middle Aged; Theophylline; Uric Acid; Xanthines

1998
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:11

    Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines

1997
[HPLC determination of five caffeine metabolites].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:8

    Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Uracil; Uric Acid; Xanthines

1997
Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow.
    Diabetes, 2002, Volume: 51, Issue:1

    Topics: Animals; Biotransformation; Capillaries; Hindlimb; Hyperinsulinism; Infusions, Intravenous; Insulin; Kinetics; Male; Microcirculation; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Uric Acid; Xanthine Oxidase; Xanthines

2002
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction.
    Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2

    Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines

2002
Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.
    European journal of clinical pharmacology, 2004, Volume: 60, Issue:1

    Topics: Acetylation; Administration, Oral; Adult; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Diet; Female; Genotype; Humans; Male; Middle Aged; Phenotype; Spectrometry, Mass, Electrospray Ionization; Time Factors; Uracil; Uric Acid; Xanthines

2004
High-throughput liquid chromatography-tandem mass spectrometry assay for plasma theophylline and its metabolites.
    Clinical chemistry, 2004, Volume: 50, Issue:11

    Topics: Bronchodilator Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Plasma; Theophylline; Uric Acid; Xanthines

2004
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:3

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Theophylline; Uracil; Uric Acid; Xanthines

2006
Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay.
    Clinica chimica acta; international journal of clinical chemistry, 2007, Volume: 376, Issue:1-2

    Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Biotransformation; Caffeine; Genotype; Humans; Male; Middle Aged; Phenotype; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Uracil; Uric Acid; White People; Xanthines

2007
Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls.
    European journal of clinical pharmacology, 2006, Volume: 62, Issue:12

    Topics: Administration, Oral; Adolescent; Adult; Biometry; Caffeine; Cohort Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Female; Genotype; Humans; Male; Methylation; Middle Aged; Polychlorinated Biphenyls; Sex Factors; Smoking; Uracil; Uric Acid; Xanthines

2006
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.
    Biomedical chromatography : BMC, 2007, Volume: 21, Issue:2

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines

2007
Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?
    European journal of clinical pharmacology, 2009, Volume: 65, Issue:4

    Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Humans; Male; Phenotype; Time Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines

2009
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.
    Journal of bacteriology, 2009, Volume: 191, Issue:14

    Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines

2009
N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population.
    Journal of clinical pharmacology, 2011, Volume: 51, Issue:7

    Topics: Acetylation; Adolescent; Adult; Arylamine N-Acetyltransferase; Caffeine; Female; Genetic Association Studies; Haplotypes; Humans; Isoenzymes; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Serbia; Uracil; Uric Acid; White People; Xanthines; Young Adult

2011
Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:10

    Topics: Arylamine N-Acetyltransferase; Asian People; Caffeine; Contraceptives, Oral; Genotype; Humans; Phenotype; Polymorphism, Single Nucleotide; Sex Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines

2012
Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Mar-15, Volume: 889-890

    Topics: Animals; Chromatography, Liquid; Drug Stability; Least-Squares Analysis; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines

2012
[Effect of Tibetan medicine zuotai on the activity, protein and mRNA expression of CYP1A2 and NAT2].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:2

    Topics: Administration, Oral; Animals; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Male; Medicine, Tibetan Traditional; Rats; Rats, Sprague-Dawley; RNA, Messenger; Theophylline; Uracil; Uric Acid; Xanthines

2014
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake.
    The Journal of nutrition, 2015, Volume: 145, Issue:4

    Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult

2015
N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:7

    Topics: Adult; Arylamine N-Acetyltransferase; Black People; Caffeine; Ethiopia; Female; Gene-Environment Interaction; Genotype; Humans; Male; Phenotype; Polymorphism, Single Nucleotide; Sweden; Uracil; Uric Acid; Xanthines

2018