1-methylspermidine has been researched along with spermidine in 19 studies
| Studies (1-methylspermidine) | Trials (1-methylspermidine) | Recent Studies (post-2010) (1-methylspermidine) | Studies (spermidine) | Trials (spermidine) | Recent Studies (post-2010) (spermidine) |
|---|---|---|---|---|---|
| 20 | 1 | 3 | 5,643 | 28 | 1,281 |
| Protein | Taxonomy | 1-methylspermidine (IC50) | spermidine (IC50) |
|---|---|---|---|
| Pyruvate kinase PKM | Homo sapiens (human) | 1.41 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Coward, JK; Lakanen, JR; Pegg, AE | 1 |
| Byers, TL; Hu, RH; Pegg, AE; Wechter, RS | 1 |
| Byers, TL; Coward, JK; Lakanen, JR; Pegg, AE | 1 |
| Coward, JK; Lakanen, JR; Pegg, AE; Poulin, R | 1 |
| Andreasson, B; Nordenskiöld, L; Schultz, J | 1 |
| Hu, RH; Pegg, AE | 1 |
| Alhonen, L; Herzig, KH; Janne, J; Keinanen, T; Khomutov, AR; Rasanen, TL; Sinervirta, R; Suppola, S; Vepsalainen, J | 1 |
| Pillai, CK; Saminathan, M; Shirahata, A; Thomas, T; Thomas, TJ | 1 |
| Alhonen, L; Grigorenko, N; Hyvönen, MT; Jänne, J; Järvinen, A; Keinänen, TA; Khomutov, AR; Porter, CW; Sinervirta, R; Uimari, A; Vepsäläinen, J; Vujcic, S | 1 |
| Alhonen, LI; Cerrada-Gimenez, M; Grigorenko, NA; Jänne, JE; Järvinen, AJ; Keinänen, TA; Khomutov, AR; Sinervirta, RM; Vepsäläinen, JJ | 1 |
| Alhonen, L; Cerrada-Gimenez, M; Grigorenko, N; Hyvönen, MT; Jänne, J; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J | 1 |
| Alhonen, L; Anderson, CB; Grigorenko, N; Howard, MT; Hyvönen, MT; Jänne, J; Keinänen, TA; Khomutov, AR; Vepsäläinen, J | 1 |
| Alhonen, L; Cerrada-Gimenez, M; Jänne, J; Keinänen, TA; Khomutov, AR; Pietilä, M; Pirinen, E; Uimari, A; Vuohelainen, S | 1 |
| Alhonen, L; Fashe, TM; Grigorenko, NA; Jänne, J; Keinänen, TA; Khomutov, AR; Pietilä, M | 1 |
| Alhonen, L; Grigorenko, N; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J | 1 |
| Alhonen, L; Fashe, T; Grigorenko, N; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J | 1 |
| Mandal, A; Mandal, S; Park, MH | 1 |
| Marzani, B; Pinto, D; Rinaldi, F; Sorbellini, E | 1 |
| Hardman, JA; Harries, M; Mironov, A; Nicu, C; Paus, R; Purba, TS; Tai, C | 1 |
1 trial(s) available for 1-methylspermidine and spermidine
| Article | Year |
|---|---|
New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies.
Topics: Administration, Topical; Adolescent; Adult; Alopecia; Autophagy; Butanols; Cell Line, Tumor; Chronic Disease; Cyclopentanes; Double-Blind Method; Female; Follow-Up Studies; Hair; Humans; Male; Middle Aged; Skin Cream; Spermidine; Treatment Outcome; Young Adult | 2018 |
18 other study(ies) available for 1-methylspermidine and spermidine
| Article | Year |
|---|---|
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.
Topics: Animals; Cell Division; Cell Line, Transformed; Colonic Neoplasms; Eflornithine; Humans; Leukemia L1210; Methylation; Mice; Putrescine; Spermidine; Spermine; Spermine Synthase; Substrate Specificity; Tumor Cells, Cultured | 1992 |
Effects of the S-adenosylmethionine decarboxylase inhibitor, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Cell Division; CHO Cells; Cricetinae; Cycloheximide; Deoxyadenosines; Eflornithine; Kinetics; Polyamines; Putrescine; Spermidine; Spermine | 1994 |
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Deoxyadenosines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Leukemia L1210; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine; Spermine; Substrate Specificity; Tumor Cells, Cultured | 1994 |
Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress.
Topics: Animals; Biological Transport; Cell Division; Cell Survival; Leukemia L1210; Mice; Ornithine Decarboxylase; Osmotic Pressure; Putrescine; Spermidine; Tumor Cells, Cultured | 1993 |
Interactions of spermidine and methylspermidine with DNA studied by nuclear magnetic resonance self-diffusion measurements.
Topics: Animals; Binding Sites; Biophysical Phenomena; Biophysics; Cattle; Diffusion; DNA; In Vitro Techniques; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Solutions; Spermidine; Static Electricity | 1996 |
Rapid induction of apoptosis by deregulated uptake of polyamine analogues.
Topics: Alkylation; Animals; Apoptosis; Cell Death; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Eflornithine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Putrescine; Spermidine; Spermine | 1997 |
A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism.
Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Immunohistochemistry; Liver; Mice; Pancreatitis; Polyamines; Proliferating Cell Nuclear Antigen; Protein Binding; Rats; Regeneration; Spermidine; Spermine; Time Factors; Zinc | 2002 |
Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics.
Topics: Animals; Cattle; Crystallization; DNA; Genetic Therapy; Methenamine; Microscopy, Polarization; Nucleic Acid Conformation; Polyamines; Spermidine; Spermine; Structure-Activity Relationship; Thymus Gland | 2002 |
Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines.
Topics: Acetyltransferases; Animals; Animals, Genetically Modified; Biotransformation; Drug Stability; Fibroblasts; Kinetics; Liver; Methylation; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Rats; Spermidine; Tissue Distribution | 2005 |
Alpha-methyl polyamines: efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase.
Topics: Animals; Animals, Genetically Modified; Dose-Response Relationship, Drug; Drug Tolerance; Fibroblasts; Humans; In Vitro Techniques; Kidney; Liver; Mice; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Pancreas; Polyamine Oxidase; Rats; Recombinant Proteins; Spermidine; Spermine; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2006 |
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Cell Proliferation; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Humans; Kinetics; Lysine; Models, Biological; Pancreatitis; Peptide Initiation Factors; Polyamines; Rats; Recombinant Proteins; RNA-Binding Proteins; Spermidine; Stereoisomerism | 2007 |
Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.
Topics: Animals; Cell Line; Cell Line, Tumor; Cells, Cultured; DNA Methylation; Dose-Response Relationship, Drug; Enzymes; Humans; Mice; Polyamines; Spermidine; Stereoisomerism | 2009 |
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Cell Differentiation; Cell Proliferation; Cell Shape; Eflornithine; Fibroblasts; Gene Expression Regulation; Glucose Transporter Type 4; Isomerism; Lipid Metabolism; Mice; Organ Specificity; Putrescine; Spermidine; Time Factors | 2010 |
Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice.
Topics: Administration, Cutaneous; Animals; beta Catenin; Cell Proliferation; Cells, Cultured; Female; Hair Follicle; Keratinocytes; Mice; Mice, Inbred C57BL; Polyamines; Spermidine | 2010 |
alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage.
Topics: Acetyltransferases; Animals; Carbon Tetrachloride; Female; Liver; Pancreas; Polyamines; Protective Agents; Rats; Rats, Transgenic; Rats, Wistar; Spermidine | 2010 |
Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis.
Topics: Acetyltransferases; Animals; Blood Coagulation; Blood Coagulation Disorders; Disease Models, Animal; Fibrinolysis; Hemostasis; Pancreatitis; Polyamines; Rats; Rats, Transgenic; Spermidine | 2010 |
Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N¹-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells.
Topics: Acetyltransferases; Antimetabolites; Apoptosis; Apoptosis Regulatory Proteins; Cell Proliferation; Cell Shape; Cell Size; HEK293 Cells; Humans; In Situ Nick-End Labeling; Kidney; Kinetics; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Mitochondria; Recombinant Proteins; Spermidine; Spermine | 2015 |
Does dysfunctional autophagy contribute to immune privilege collapse and alopecia areata pathogenesis?
Topics: Adult; Alopecia Areata; Apoptosis; Autophagy; Biopsy; Case-Control Studies; Dietary Supplements; Female; Hair Follicle; Healthy Volunteers; Humans; Immune Privilege; Interferon-gamma; Male; Microscopy, Electron, Transmission; Middle Aged; Pilot Projects; Scalp; Spermidine; Young Adult | 2020 |