1-methyl-4-piperidyl acetate has been researched along with phenyl acetate in 23 studies
| Studies (1-methyl-4-piperidyl acetate) | Trials (1-methyl-4-piperidyl acetate) | Recent Studies (post-2010) (1-methyl-4-piperidyl acetate) | Studies (phenyl acetate) | Trials (phenyl acetate) | Recent Studies (post-2010) (phenyl acetate) |
|---|---|---|---|---|---|
| 24 | 5 | 10 | 41,232 | 1,558 | 8,330 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukushi, K; Ikota, N; Irie, T; Iyo, M; Nagatsuka, S; Namba, H; Tamagami, H | 1 |
| Bormans, G; Kilbourn, MR; Sherman, P; Snyder, SE | 1 |
| Fukushi, K; Irie, T; Iyo, M; Nagatsuka, S; Namba, H; Shinotoh, H; Sudo, Y; Suhara, T; Suzuki, K | 1 |
| Aotsuka, A; Fukushi, K; Irie, T; Iyo, M; Nagatsuka , S; Namba, H; Ota, T; Shinotoh, H; Tanada, S; Tanaka, N | 1 |
| Bauer, B; Heiss, WD; Herholz, K; Lenz, O; Lercher, M; Wienhard, K | 1 |
| Bauer, B; Heiss, WD; Herholz, K; Kracht, L; Lenz, MO; Mielke, R; Strotmann, T; Wienhard, K | 1 |
| Aotsuka, A; Fukushi, K; Irie, T; Iyo, M; Nagatsuka Si, S; Namba, H; Ota, T; Shinotoh, H; Tanada, S; Tanaka, N | 1 |
| Järvenpää, T; Kaasinen, V; Kurki, T; Någren, K; Oikonen, V; Rinne, JO; Roivainen, A; Yu, M | 1 |
| Furutsuka, K; Irie, T; Kida, T; Kikuchi, T; Maeda, J; Okauchi, T; Suzuki, K; Zhang, MR | 1 |
| Bauer, B; Heiss, WD; Herholz, K; Kalbe, E; Lenz, O; Schröder, H; Weisenbach, S; Zündorf, G | 1 |
| Aotsuka, A; Arai, H; Fukushi, K; Irie, T; Iyo, M; Nagatsuka, S; Namba, H; Ota, T; Sato, K; Shinotoh, H; Shiraishi, T; Tanada, S; Tanaka, N | 1 |
| Bosso, N; Carpinelli, A; Cattaneo, A; Fazio, F; Galli Kienle, M; Magni, F; Matarrese, M; Todde, S; Turolla, E | 1 |
| Burghaus, L; Heiss, WD; Herholz, K; Hilker, R; Jacobs, AH; Kalbe, E; Klein, JC; Thomas, AV; Weisenbach, S | 1 |
| Futatsubashi, M; Irie, T; Iwata, Y; Kikuchi, M; Matsumoto, K; Mori, N; Nakamura, K; Ouchi, Y; Suda, S; Sugihara, G; Sugiyama, T; Suzuki, K; Takebayashi, K; Takei, N; Tsuchiya, KJ; Tsujii, M; Wakuda, T; Yoshihara, Y | 1 |
| Arponen, E; Luoto, P; Någren, K; Oikonen, V; Östberg, A; Rinne, JO; Tenovuo, O; Virta, J | 1 |
| Bertoldo, A; Borroni, B; Cappa, SF; Carpinelli, A; Florea, I; Garibotto, V; Herholz, K; Marcone, A; Moresco, RM; Padovani, A; Panzacchi, A; Perani, D; Rinne, JO; Tettamanti, M; Virta, JR | 1 |
| Fukumura, T; Fukushi, K; Irie, T; Kikuchi, T; Ohya, T; Zhang, MR | 1 |
| Cappa, SF; Florea, I; Garibotto, V; Marcone, A; Moresco, R; Panzacchi, A; Perani, D; Rinne, J; Tettamanti, M; Virta, JR | 1 |
| Allendorf, I; Dietlein, M; Fink, GR; Kracht, L; Kukolja, J; Neumaier, B; Onur, OA; Richter, N; Tittgemeyer, M | 1 |
| Dietlein, M; Fink, GR; Kracht, L; Kukolja, J; Michel, A; Neumaier, B; Onur, OA; Richter, N; Tittgemeyer, M | 1 |
| Beckers, N; Dietlein, M; Fink, GR; Kracht, L; Kukolja, J; Neumaier, B; Onur, OA; Richter, N; Tittgemeyer, M | 1 |
| Fukushi, K; Higuchi, M; Hirano, S; Irie, T; Kuwabara, S; Ota, T; Sato, K; Shimada, H; Shinotoh, H; Suhara, T; Tanaka, N; Zhang, MR | 1 |
| Dietlein, M; Dillen, K; Dronse, J; Fink, GR; Jacobs, HIL; Kracht, L; Kukolja, J; Langen, KJ; Nellessen, N; Neumaier, B; Onur, OA; Richter, N | 1 |
5 trial(s) available for 1-methyl-4-piperidyl acetate and phenyl acetate
| Article | Year |
|---|---|
Positron emission tomographic measurement of brain acetylcholinesterase activity using N-[(11)C]methylpiperidin-4-yl acetate without arterial blood sampling: methodology of shape analysis and its diagnostic power for Alzheimer's disease.
Topics: Acetates; Acetylcholinesterase; Aged; Alzheimer Disease; Arteries; Blood Specimen Collection; Brain; Carbon Radioisotopes; Humans; Middle Aged; Monte Carlo Method; Piperidines; Tomography, Emission-Computed | 2001 |
Kinetic analysis of [(11)C]MP4A using a high-radioactivity brain region that represents an integrated input function for measurement of cerebral acetylcholinesterase activity without arterial blood sampling.
Topics: Acetates; Acetylcholinesterase; Adult; Aged; Alzheimer Disease; Blood Specimen Collection; Brain; Carbon Radioisotopes; Computer Simulation; Humans; Kinetics; Least-Squares Analysis; Middle Aged; Models, Biological; Piperidines; Tomography, Emission-Computed | 2001 |
Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease.
Topics: Acetates; Acetylcholinesterase; Aged; Alzheimer Disease; Analysis of Variance; Brain; Carbon Radioisotopes; Cognition Disorders; Female; Hippocampus; Humans; Imaging, Three-Dimensional; Male; Middle Aged; Neuropsychological Tests; Piperidines; Predictive Value of Tests; Reference Values; Tomography, Emission-Computed | 2003 |
A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT.
Topics: Acetates; Acetylcholinesterase; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Carbon Radioisotopes; Cerebral Cortex; Female; Humans; Image Interpretation, Computer-Assisted; Iofetamine; Male; Middle Aged; Piperidines; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2004 |
Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways.
Topics: Acetates; Acetylcholine; Acetylcholinesterase; Aged; Atrophy; Binding, Competitive; Brain; Brain Mapping; Dihydroxyphenylalanine; Dopamine; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Neuropsychological Tests; Parkinson Disease; Piperidines; Positron-Emission Tomography; Synaptic Transmission | 2005 |
18 other study(ies) available for 1-methyl-4-piperidyl acetate and phenyl acetate
| Article | Year |
|---|---|
Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease.
Topics: Acetates; Acetylcholinesterase; Alzheimer Disease; Amphetamines; Animals; Brain; Carbon Radioisotopes; Iodine Radioisotopes; Iofetamine; Male; Piperidines; Propionates; Rats; Rats, Wistar; Sensitivity and Specificity; Tomography, Emission-Computed | 1996 |
Synthesis of carbon-11- and fluorine-18-labeled 1-methyl-4-piperidyl-4'-fluorobenzoate and their biodistribution in mice.
Topics: Acetates; Animals; Benzoates; Carbon Radioisotopes; Female; Fluorine Radioisotopes; Isotope Labeling; Mice; Mice, Inbred Strains; Piperidines; Tissue Distribution | 1996 |
Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age.
Topics: Acetates; Acetylcholinesterase; Adult; Aged; Aged, 80 and over; Aging; Brain; Carbon Radioisotopes; Cerebral Cortex; Chromatography, Thin Layer; Female; Humans; Male; Middle Aged; Nerve Degeneration; Piperidines; Reference Values; Thalamus; Tomography, Emission-Computed | 1999 |
PET measurement of cerebral acetylcholine esterase activity without blood sampling.
Topics: Acetates; Acetylcholinesterase; Aged; Algorithms; Alzheimer Disease; Basal Ganglia; Brain; Female; Humans; Lewy Body Disease; Male; Middle Aged; Piperidines; Radiopharmaceuticals; Tomography, Emission-Computed | 2001 |
In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism.
Topics: Acetates; Acetylcholinesterase; Aged; Alzheimer Disease; Brain; Brain Stem; Carbon Radioisotopes; Cerebellum; Cerebrovascular Circulation; Corpus Striatum; Female; Glucose; Humans; Lewy Body Disease; Male; Mental Status Schedule; Middle Aged; Piperidines; Reference Values; Regression Analysis; Thalamus; Tomography, Emission-Computed | 2000 |
N-[18F]fluoroethyl-4-piperidyl acetate ([18F]FEtP4A): A PET tracer for imaging brain acetylcholinesterase in vivo.
Topics: Acetates; Acetylcholinesterase; Animals; Autoradiography; Brain; Carbon Radioisotopes; Fluorine Radioisotopes; Hydrolysis; Macaca mulatta; Male; Piperidines; Radiopharmaceuticals; Rats; Sensitivity and Specificity; Tomography, Emission-Computed | 2003 |
In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease.
Topics: Acetates; Acetylcholinesterase; Aged; Alzheimer Disease; Amygdala; Basal Nucleus of Meynert; Blood Glucose; Carbon Radioisotopes; Cerebral Cortex; Cholinergic Fibers; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Piperidines; Tomography, Emission-Computed | 2004 |
Improved synthesis and radiolabeling of [11C]MP4A, a suitable ligand for the investigation of the cholinergic system using PET.
Topics: Acetates; Acetylation; Acetylcholinesterase; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Hydrocarbons, Iodinated; Isotope Labeling; Magnetic Resonance Spectroscopy; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals | 2006 |
Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders.
Topics: Acetates; Acetylcholinesterase; Adolescent; Adult; Brain Mapping; Carbon Radioisotopes; Child; Child Development Disorders, Pervasive; Communication; Female; Humans; Image Processing, Computer-Assisted; Male; Piperidines; Positron-Emission Tomography; Reference Values; Social Behavior; Stereotyped Behavior; Temporal Lobe; Young Adult | 2011 |
Cholinergic dysfunction after traumatic brain injury: preliminary findings from a PET study.
Topics: Acetates; Acetylcholinesterase; Adult; Brain; Brain Injuries; Brain Mapping; Carbon Radioisotopes; Cognition Disorders; Female; Humans; Male; Middle Aged; Piperidines; Positron-Emission Tomography; Radioligand Assay | 2011 |
[11C]-MP4A PET cholinergic measurements in amnestic mild cognitive impairment, probable Alzheimer's disease, and dementia with Lewy bodies: a Bayesian method and voxel-based analysis.
Topics: Acetates; Acetylcholinesterase; Aged; Aged, 80 and over; Amnesia; Bayes Theorem; Carbon Radioisotopes; Cognitive Dysfunction; Female; Humans; Lewy Body Disease; Male; Middle Aged; Piperidines; Positron-Emission Tomography | 2012 |
A method to predict the ratio of the tracer conversion rate to the tracer back-diffusion rate of an irreversible-type radiotracer in humans by preclinical evaluations.
Topics: Acetates; Acetylcholinesterase; Animals; Cerebral Cortex; Diffusion; Humans; Kinetics; Models, Biological; Piperidines; Positron-Emission Tomography; Propionates; Radioactive Tracers; Rats; Reproducibility of Results; Species Specificity | 2012 |
Cholinergic activity correlates with reserve proxies in Alzheimer's disease.
Topics: Acetates; Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Carbon Isotopes; Cognitive Dysfunction; Cognitive Reserve; Educational Status; Employment; Female; Fluorodeoxyglucose F18; Humans; Male; Mental Status Schedule; Middle Aged; Piperidines; Positron-Emission Tomography; Radiography; Statistics, Nonparametric; Tomography Scanners, X-Ray Computed | 2013 |
The integrity of the cholinergic system determines memory performance in healthy elderly.
Topics: Acetates; Acetylcholinesterase; Aged; Aging; Cerebral Cortex; Female; Humans; Magnetic Resonance Imaging; Male; Memory, Episodic; Middle Aged; Piperidines; Positron-Emission Tomography | 2014 |
White matter lesions and the cholinergic deficit in aging and mild cognitive impairment.
Topics: Acetates; Acetylcholinesterase; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognitive Dysfunction; Female; Humans; Male; Memory; Middle Aged; Neuropsychological Tests; Piperidines; Positron-Emission Tomography; White Matter | 2017 |
Effect of cholinergic treatment depends on cholinergic integrity in early Alzheimer's disease.
Topics: Acetates; Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cerebral Cortex; Cholinergic Agents; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Oxygen; Piperidines; Positron-Emission Tomography; Rivastigmine | 2018 |
Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease.
Topics: Acetates; Acetylcholinesterase; Age of Onset; Aged; Aging; Alzheimer Disease; Brain; Brain Mapping; Carbon Radioisotopes; Female; Humans; Male; Middle Aged; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals | 2018 |
Spatial distributions of cholinergic impairment and neuronal hypometabolism differ in MCI due to AD.
Topics: Acetates; Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals | 2019 |