1-methyl-4-phenyl-2,3-dihydropyridinium has been researched along with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in 31 studies
| Studies (1-methyl-4-phenyl-2,3-dihydropyridinium) | Trials (1-methyl-4-phenyl-2,3-dihydropyridinium) | Recent Studies (post-2010) (1-methyl-4-phenyl-2,3-dihydropyridinium) | Studies (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) | Trials (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) | Recent Studies (post-2010) (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) |
|---|---|---|---|---|---|
| 46 | 0 | 3 | 3,859 | 8 | 1,052 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (45.16) | 18.7374 |
| 1990's | 12 (38.71) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Delanney, LE; Di Monte, DA; Irwin, I; Langston, JW; Wu, EY | 1 |
| Chiueh, CC; Obata, T | 1 |
| Misra, HP; Zang, LY | 1 |
| Das, NP; Moochhala, SM; Sato, T; Shahi, GS; Sunamoto, J | 1 |
| Albanese, A; Del Zompo, M; Morelli, M; Piccardi, MP; Ruiu, S | 1 |
| Jenner, P; Marsden, CD; Walker, MJ | 1 |
| Doyle, TJ; Lau, YS; Wilson, JA | 1 |
| Krueger, MJ; McKeown, K; Ramsay, RR; Singer, TP; Youngster, SK | 1 |
| Chiba, K; Horii, H; Ishizaki, T; Kato, Y; Kubota, E | 1 |
| Arora, PK; Blue, P; Harik, SI; Iacofano, LA; Sayre, LM; Schmidley, JW | 1 |
| Hiebert, CK; Sayre, LM; Silverman, RB | 1 |
| Chacón, JN; Chedekel, MR; Land, EJ; Truscott, TG | 1 |
| Felix, CC; Kalyanaraman, B; Korytowski, W | 1 |
| Cashman, JR | 2 |
| Bocchetta, A; Corsini, GU; Del Zompo, M; Piccardi, MP; Pintus, S | 1 |
| Castagnoli, N; Salach, JI; Singer, TP; Trevor, A | 1 |
| Castagnoli, N; Chiba, K; Trevor, AJ; Wu, EY | 1 |
| Castagnoli, N; Ramsay, RR; Singer, TP; Trevor, AJ | 1 |
| Di Monte, D; Ekström, G; Sandy, MS; Smith, MT | 1 |
| Castagnoli, N; Di Monte, D; Ekström, G; Shinka, T; Smith, MT; Trevor, AJ | 1 |
| Jonsson, G; Luthman, J; Nwanze, E; Sundström, E | 1 |
| Crabtree, D; Salach, JI; Singer, TP | 1 |
| McCrodden, JM; Sullivan, JP; Tipton, KF | 1 |
| Cosi, C; Marien, M | 1 |
| Ohta, S; Yoshihara, S | 1 |
| Castagnoli, N; Khalil, AA; Steyn, S | 1 |
| Galisteo, J; Guillén, H; Herraiz, T | 2 |
| Herraiz, T | 1 |
| Brunner, T; Cirri, E; Ferger, B; Friemel, A; Hiller, K; Karreman, C; Leist, M; Marx, A; Meiser, J; Möller, HM; Odermatt, M; Pape, R; Pasquarelli, N; Ringwald, M; Schildknecht, S; Strittmatter, T | 1 |
1 review(s) available for 1-methyl-4-phenyl-2,3-dihydropyridinium and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Article | Year |
|---|---|
Metabolic aspects of the behavior of MPTP and some analogues.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Humans; Monoamine Oxidase; Parkinson Disease, Secondary; Pyridinium Compounds; Structure-Activity Relationship; Substantia Nigra | 1993 |
30 other study(ies) available for 1-methyl-4-phenyl-2,3-dihydropyridinium and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Article | Year |
|---|---|
Production and disposition of 1-methyl-4-phenylpyridinium in primary cultures of mouse astrocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Astrocytes; Biotransformation; Bucladesine; Cell Death; Cells, Cultured; Extracellular Space; Mice; Monoamine Oxidase; Prosencephalon; Pyridinium Compounds | 1992 |
In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dialysis; Dopamine; Free Radicals; Hydroxides; Hydroxyl Radical; Male; Nerve Endings; Perfusion; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Salicylates; Salicylic Acid; Substantia Nigra | 1992 |
EPR kinetic studies of superoxide radicals generated during the autoxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium, a bioactivated intermediate of parkinsonian-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrogen-Ion Concentration; Kinetics; Mathematics; Oxidation-Reduction; Parkinson Disease, Secondary; Pyridinium Compounds; Spin Labels; Superoxides | 1992 |
Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its toxic metabolites on the physicochemical property of the liposomal membrane in relation to their cytochrome P-450 inhibition.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Dimyristoylphosphatidylcholine; Fluoresceins; Fluorescent Dyes; Kinetics; Liposomes; Male; Membrane Fluidity; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Pyridinium Compounds; Spectrometry, Fluorescence | 1992 |
Localization of MPP+ binding sites in the brain of various mammalian species.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Brain Chemistry; Callithrix; Corpus Striatum; Female; Image Processing, Computer-Assisted; Male; Mice; Monoamine Oxidase; Oxidopamine; Pyridinium Compounds; Rats; Rats, Inbred Strains; Species Specificity | 1992 |
A redox reaction between MPP+ and MPDP+ to produce superoxide radicals does not impair mitochondrial function.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Free Radicals; Male; Mitochondria; MPTP Poisoning; Oxidation-Reduction; Oxygen Consumption; Pyridinium Compounds; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Superoxide Dismutase; Superoxides | 1991 |
MPTP, MPDP+ and MPP+ cause decreases in dopamine content in mouse brain slices.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Dopamine; In Vitro Techniques; Mice; Mice, Inbred C57BL; Pyridinium Compounds | 1990 |
Mechanism-based inactivation of monoamine oxidases A and B by tetrahydropyridines and dihydropyridines.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Pregnancy; Pyridinium Compounds; Spectrophotometry; Substrate Specificity | 1990 |
Effects of N-methylmercaptoimidazole on the disposition of MPTP and its metabolites in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Cerebral Cortex; Corpus Striatum; Half-Life; Male; Methimazole; Mice; Mixed Function Oxygenases; Pyridinium Compounds | 1990 |
On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: the effect of perinigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, its metabolite and their analogs in the rat.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Histocytochemistry; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Neurons; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains; Serotonin; Substantia Nigra | 1987 |
Inactivation of monoamine oxidase by 3,3-dimethyl analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-2,3-dihydropyridinium ion. Dramatic effect of beta-mercaptoethanol on substrate turnover and enzyme inactivation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cattle; Kinetics; Mercaptoethanol; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyridinium Compounds; Substrate Specificity | 1989 |
Chemically induced Parkinson's disease. II: Intermediates in the oxidation and reduction reactions of the 1-methyl-4-phenyl-2,3-dihydropyridinium ion and its deprotonated form.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Electrons; Humans; Indicators and Reagents; Kinetics; Oxidation-Reduction; Parkinson Disease, Secondary; Photolysis; Pyridines; Pyridinium Compounds; Spectrophotometry | 1989 |
Oxygen activation during the interaction between MPTP metabolites and synthetic neuromelanin--an ESR-spin trapping, optical, and oxidase electrode study.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Dopamine; Electrodes; Electron Spin Resonance Spectroscopy; Hydroxides; Hydroxyl Radical; Melanins; Oxidoreductases; Oxygen; Pyridines; Pyridinium Compounds | 1988 |
Mutagenicity of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its metabolites.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biotransformation; Methylnitronitrosoguanidine; Monoamine Oxidase; Mutagenicity Tests; Pyridines; Pyridinium Compounds; Salmonella typhimurium; Zimeldine | 1987 |
Facile N-oxygenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by the flavin-containing monooxygenase. A convenient synthesis of tritiated [methyl-3H]-4-phenyl-2,3-dihydropyridinium species.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Microsomes, Liver; Oxygenases; Pyridines; Pyridinium Compounds; Swine; Tritium | 1988 |
A reactive metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is formed in rat brain in vitro by type B monoamine oxidase.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Biotransformation; Brain; In Vitro Techniques; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains | 1986 |
Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Dialysis; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Pyridines; Pyridinium Compounds; Spectrophotometry | 1986 |
Interactions of the 1-methyl-4-phenyl-2,3-dihydropyridinium species with synthetic dopamine-melanin.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Dopamine; Melanins; Oxidation-Reduction; Pyridines; Pyridinium Compounds | 1986 |
Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Biotransformation; Brain; Humans; Mitochondria; Monoamine Oxidase; NAD; Parkinson Disease, Secondary; Pyridines; Pyridinium Compounds; Rats | 1987 |
Comparative toxicity and antioxidant activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its monoamine oxidase B-generated metabolites in isolated hepatocytes and liver microsomes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; In Vitro Techniques; Lipid Peroxides; Liver; Male; Microsomes, Liver; Monoamine Oxidase; Pyridines; Pyridinium Compounds; Rats; Rats, Inbred Strains | 1987 |
Role of 1-methyl-4-phenylpyridinium ion formation and accumulation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity to isolated hepatocytes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine Triphosphate; Animals; Biotransformation; Dose-Response Relationship, Drug; Ions; Liver; Male; Pargyline; Pyridines; Pyridinium Compounds; Rats | 1987 |
Effect of MPTP and its pyridinium metabolites on monoamine uptake and on central catecholamine neurons in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Dopamine; Fluorescent Antibody Technique; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Monoamine Oxidase; Neurons; Norepinephrine; Pyridines; Pyridinium Compounds | 1986 |
Reversible inhibition and mechanism-based irreversible inactivation of monoamine oxidases by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Brain; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyridines; Pyridinium Compounds; Spectrophotometry | 1985 |
Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP): prevention by the poly(ADP-ribose) polymerase inhibitor, benzamide.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Benzamides; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Agents; Frontal Lobe; Male; Mesencephalon; Mice; Mice, Inbred C57BL; NAD; Neuroprotective Agents; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Pyridinium Compounds | 1998 |
Involvement of hepatic aldehyde oxidase in conversion of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+) to 1-methyl-4-phenyl-5,6-dihydro-2-pyridone.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Biotransformation; Lactams; Male; Mice; Mice, Inbred ICR; Mitochondria, Liver; Pyridinium Compounds; Pyridones | 1998 |
Isolation and characterization of a monoamine oxidase inhibitor from tobacco leaves.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding, Competitive; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Gastric Mucosa; Humans; Intestinal Mucosa; Kinetics; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nicotiana; Papio; Plant Leaves; Plants, Toxic; Pyridinium Compounds | 2000 |
N-methyltetrahydro-beta-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic beta-carbolinium cations by heme peroxidases.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Carbolines; Cations; Chromatography, High Pressure Liquid; Heme; Kinetics; Models, Chemical; Neurotoxins; Oxidation-Reduction; Peroxidases; Pyridinium Compounds; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2007 |
Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Carbolines; Chromatography, High Pressure Liquid; Clorgyline; Enzyme Assays; Harmine; Humans; Indazoles; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Nicotiana; Oxidation-Reduction; Pyridinium Compounds; Recombinant Proteins; Selegiline; Smoke; Vitamin K 3 | 2012 |
Metabolite profile resulting from the activation/inactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-methyltetrahydro-β-carboline by oxidative enzymes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Carbolines; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzymes; Humans; Metabolomics; Monoamine Oxidase; Oxidation-Reduction; Peroxidases; Pyridinium Compounds | 2013 |
Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Astrocytes; Biological Transport; Catecholamines; Cell Line; Cell Membrane; Diffusion; Dopaminergic Neurons; Extracellular Fluid; Humans; Monoamine Oxidase; Oxidation-Reduction; Parkinson Disease; Pyridinium Compounds | 2015 |