Compounds > 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactic acid

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with lactic acid in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19903 (20.00)18.7374
1990's4 (26.67)18.2507
2000's7 (46.67)29.6817
2010's1 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Basma, AN; Geller, HM; Heikkila, RE; Nicklas, WJ; Philbert, M; Saporito, MS1
Andersen, JK; Howard, BD; Rozenberg, YY; Zhang, MB; Zhong, XH1
Booth, RG; Caldera, P; Castagnoli, N; Johnson, EA; Lampen, P; Naiman, N; Rollema, H; Trevor, AJ; Youngster, SK1
Heikkila, RE; Nicklas, WJ; Ofori, S1
Damsma, G; de Vries, JB; Horn, AS; Kranenborg, GL; Kuhr, WG; Rollema, H; Westerink, BH1
Heikkila, RE; Kindt, MV; Nicklas, WJ1
Samuelsson, EB; Sundström, E1
Bergh, JJ; Castagnoli, N; Mienie, LJ; Petzer, JP; Van der Schyf, CJ1
Di Monte, DA; Langston, JW; Thiffault, C1
Hirata, Y; Kiuchi, K; Nagatsu, T1
Mazzio, E; Soliman, KF; Yoon, KJ1
Behrouz, B; Drolet, RE; Goudreau, JL; Lookingland, KJ1
Ishikawa, M; Kitagawa, H; Koga, K; Kurihara, N; Mitsumoto, Y; Mori, A; Nakai, M; Ohashi, S1
Abert, B; Bodard, S; Castelnau, P; Chalon, S; Lagrue, E; Lombes, A; Medja, F; Nadal, L; Tabone, L1
Agarwal, S; Bhatnagar, P; Brashket, S; Chaturvedi, RK; Gupta, KC; Kumar, P; Patel, DK; Singh, MP; Singhal, NK; Srivastava, G; Tiwari, MN; Tiwari, SK1

Other Studies

15 other study(ies) available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactic acid

ArticleYear
1-Methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells is enhanced by preventing glycolysis.
    Journal of neurochemistry, 1992, Volume: 58, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Glucose; Glycolysis; Lactates; Lactic Acid; PC12 Cells; Rotenone; Time Factors

1992
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-resistant, flat-cell PC12 variants having a partial loss of transformed phenotype.
    Journal of neurochemistry, 1990, Volume: 55, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Cell Transformation, Neoplastic; Drug Resistance; Gene Expression; Genetic Variation; Glycolysis; Isoenzymes; Karyotyping; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Mitochondria; Phenotype; Pheochromocytoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Rats; RNA, Messenger; Tumor Cells, Cultured

1990
In vivo intracerebral microdialysis studies in rats of MPP+ analogues and related charged species.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Chemical Phenomena; Chemistry; Corpus Striatum; Dialysis; Dopamine; Kinetics; Lactates; Lactic Acid; Male; Molecular Structure; MPTP Poisoning; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1990
Attenuation by dopamine uptake blockers of the inhibitory effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and some of its analogs on NADH-linked metabolism in mouse neostriatal slices.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cocaine; Corpus Striatum; Dopamine; In Vitro Techniques; Lactates; Lactic Acid; Male; Mice; NAD; Neurotransmitter Uptake Inhibitors; Rats; Tyrosine 3-Monooxygenase

1989
The use of in vivo brain dialysis of dopamine, acetylcholine, amino acids and lactic acid in studies on the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
    Toxicology, 1988, Volume: 49, Issue:2-3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 2,4-Dinitrophenol; Acetylcholine; Amino Acids; Amphetamine; Animals; Brain; Dialysis; Dinitrophenols; Dopamine; Lactates; Lactic Acid; Pyridines; Pyridinium Compounds; Rats

1988
Mitochondrial and metabolic toxicity of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Allylamine; Animals; Brain; Corpus Striatum; Dose-Response Relationship, Drug; In Vitro Techniques; Lactates; Lactic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria; Pyridines; Pyridinium Compounds

1987
Comparison of key steps in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in rodents.
    Pharmacology & toxicology, 1997, Volume: 81, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Brain; Dopamine; Lactic Acid; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Norepinephrine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Synaptosomes

1997
Metabolic defects caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and by HPTP (the tetrahydropyridinyl analog of haloperidol), in rats.
    Life sciences, 2000, Apr-07, Volume: 66, Issue:20

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antipsychotic Agents; Haloperidol; Lactic Acid; Male; Metabolism, Inborn Errors; Mitochondria; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Valerates

2000
Increased striatal dopamine turnover following acute administration of rotenone to mice.
    Brain research, 2000, Dec-08, Volume: 885, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Chelating Agents; Corpus Striatum; Ditiocarb; Dopamine; Dopamine Agents; Homovanillic Acid; Lactic Acid; Male; Mice; Mice, Inbred C57BL; Rotenone; Uncoupling Agents

2000
Manganese mimics the action of 1-methyl-4-phenylpyridinium ion, a dopaminergic neurotoxin, in rat striatal tissue slices.
    Neuroscience letters, 2001, Sep-21, Volume: 311, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Glycolysis; Hydroxylation; Lactic Acid; Male; Manganese; Manganese Poisoning; MPTP Poisoning; Neostriatum; Neurotoxins; Rats; Rats, Wistar; Tyrosine; Tyrosine 3-Monooxygenase

2001
Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells.
    Biochemical pharmacology, 2003, Jul-15, Volume: 66, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcarnitine; Adenosine Triphosphate; Animals; Cell Survival; Cytoprotection; Drug Interactions; Glucose; Lactic Acid; Mice; Neuroblastoma; Oxygen Consumption; Protective Agents; Tumor Cells, Cultured

2003
Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration.
    Neurotoxicology, 2004, Volume: 25, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; alpha-Synuclein; Animals; Blotting, Western; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Lactic Acid; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neostriatum; Nerve Tissue Proteins; Neuropeptides; Substantia Nigra; Synucleins; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins

2004
H MRS identifies lactate rise in the striatum of MPTP-treated C57BL/6 mice.
    The European journal of neuroscience, 2006, Volume: 23, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blotting, Western; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Drug Interactions; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Piperazines; Protons; Selegiline; Time Factors

2006
MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood.
    Metabolic brain disease, 2009, Volume: 24, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Basal Ganglia; Basal Ganglia Diseases; Disease Models, Animal; Dopamine; Electron Transport Complex I; Energy Metabolism; Enzyme Inhibitors; Lactic Acid; Leigh Disease; Male; Mice; Mice, Inbred C57BL; Mitochondrial Diseases; MPTP Poisoning; Neostriatum; Nerve Degeneration

2009
Mechanism of Nanotization-Mediated Improvement in the Efficacy of Caffeine Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinsonism.
    Journal of biomedical nanotechnology, 2015, Volume: 11, Issue:12

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Active Transport, Cell Nucleus; Animals; Biological Transport; Caffeine; Cell Count; Cell Nucleus; Cell Survival; Dopamine; Dopaminergic Neurons; Drug Carriers; Drug Liberation; Fluorescein-5-isothiocyanate; GAP-43 Protein; Gene Expression Regulation; Lactic Acid; Lipid Peroxidation; Male; Mice; Microglia; Nanoparticles; Neuroprotective Agents; NF-kappa B; Nitrites; Parkinsonian Disorders; Phosphoproteins; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Proto-Oncogene Proteins c-akt; RNA, Messenger

2015