Compounds > 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and carbidopa

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with carbidopa in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19909 (25.00)18.7374
1990's19 (52.78)18.2507
2000's6 (16.67)29.6817
2010's2 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aigner, TG; Cohen, RM; Doudet, DJ; McLellan, CA1
Camarata, PJ; Chae, H; Ebner, TJ; Haines, SJ; Park, SK; Parker, RG; Turner, DA1
Bédard, PJ; Di Paolo, T; Gagnon, C1
Bhatti, AR; Devlin, AJ; Ramsden, DB; Williams, AC1
Gash, DM; Kim, MH; Kurlan, R1
DeLanney, LE; Irwin, I; Langston, JW; Maze, M; Ricaurte, GA; Segal, IS; Walton, JK1
Boyce, S; Clarke, CA; Crossman, AR; Robertson, RG; Sambrook, MA1
Bakay, RA; Byrd, LD; Colbassani, HJ; Herring, CJ; Iuvone, PM; Mandir, A; Sweeney, KM; Watts, RL1
Jankovic, J1
Boyes, BE; Cumming, P; Martin, WR; McGeer, EG1
Bioulac, B; Doudet, D; Gross, C; Lebrun-Grandié, P2
Bey, P; McDonald, IA; Palfreyman, MG; Schechter, PJ; Sjoerdsma, A1
Lieberman, AN1
Bankiewicz, KS; Chiueh, CC; Doppman, JL; Jacobowitz, DM; Kopin, IJ; Oldfield, EH1
Ballard, PA; Langston, JW; Tetrud, JW1
Ballard, P; Langston, JW1
Carmichael, SW; Cook, JA; Merkel, GJ; Stoddard, SL; Zinsmeister, AR1
Bédard, PJ; Blanchette, P; DiPaolo, T; Falardeau, P; Gagnon, C; Gomez-Mancilla, B1
Eller, RV; Gash, DM; Greenamyre, JT; Kurlan, R; Ovadia, A; Zhang, Z1
Gash, DM; Kurlan, R; McDermott, M; Smith, RD; Zhang, Z1
Jackson, M; Jenner, P; Marsden, CD; Pearce, RK; Smith, L1
Andersen, AH; Avison, MJ; Chen, Q; Gash, DM; Ovadia, A; Zhang, Z1
Andrén, PE; Ekesbo, A; Gunne, LM; Tedroff, J1
Collins, F; Gash, DM; Hilt, D; Kryscio, R; Lapchak, PA; Lebel, C; Miyoshi, Y; Ovadia, A; Zhang, Z1
Gordin, A; Jenner, P; Marsden, CD; Smith, LA1
Andersen, AH; Avison, MJ; Gash, DM1
Desimone, R; Fiorani, M; Oldfield, EH; Papa, SM1
Jackson, MJ; Jenner, P; Kanda, T; Kase, H; Kuwana, Y; Nakamura, J; Pearce, RK; Smith, LA1
Bankiewicz, KS; Bringas, J; Budinger, TF; Cunningham, J; Eberling, JL; Harvey-White, J; Jagust, W; Kohutnicka, M; Pivirotto, P1
Bar-Gad, I; Bergman, H; Goldberg, JA; Heimer, G1
Hansard, MJ; Jackson, MJ; Jenner, P; Maratos, E; Smith, LA1
Hanger, D; Joyce, JN; Reploge, M; Yarkov, AV1
Al-Barghouthy, G; Jackson, MJ; Jenner, P; Kuoppamaki, M; Olanow, W; Rose, S; Smith, LA1
Fisher, R; Jackson, MJ; Jenner, P; Rose, S; Tayarani-Binazir, KA; Zoubiane, G1
Alhadhrami, A; Alharthi, SS; Alrobaian, MM; Kabel, AM; Omar, MS1

Reviews

1 review(s) available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and carbidopa

ArticleYear
Parkinson's disease: recent advances in therapy.
    Southern medical journal, 1988, Volume: 81, Issue:8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Medulla; Antiparkinson Agents; Carbidopa; Dopamine; Drug Administration Schedule; Drug Combinations; Humans; Levodopa; Middle Aged; Parkinson Disease; Parkinson Disease, Secondary; Pyridines

1988

Other Studies

35 other study(ies) available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and carbidopa

ArticleYear
Positron emission tomography with 18F-dopa: interpretation and biological correlates in nonhuman primates.
    Psychiatry research, 1992, Volume: 45, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Carbidopa; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Macaca mulatta; Methoxyhydroxyphenylglycol; Parkinson Disease, Secondary; Receptors, Dopamine; Tomography, Emission-Computed

1992
Effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-induced hemiparkinsonism on the kinematics of a two-dimensional,multijoint arm movement in the rhesus monkey.
    Neuroscience, 1992, Volume: 48, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Arm; Behavior, Animal; Carbidopa; Female; Levodopa; Macaca mulatta; Male; Movement; Parkinson Disease, Secondary; Reaction Time; Substantia Nigra; Tyrosine 3-Monooxygenase

1992
Effect of chronic treatment of MPTP monkeys with dopamine D-1 and/or D-2 receptor agonists.
    European journal of pharmacology, 1990, Mar-13, Volume: 178, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Autoradiography; Brain; Bromocriptine; Carbidopa; Catecholamines; Dopamine Agents; Female; Levodopa; Macaca fascicularis; Receptors, Dopamine; Spiperone

1990
Inhibition of human benzylamine oxidase (BzAO) by analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
    Toxicology letters, 1990, Volume: 54, Issue:2-3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Benzylamine Oxidase; Carbidopa; Dopamine Agents; Humans; Kinetics; Parkinson Disease; Selegiline

1990
Oral levodopa dose-response study in MPTP-induced hemiparkinsonian monkeys: assessment with a new rating scale for monkey parkinsonism.
    Movement disorders : official journal of the Movement Disorder Society, 1991, Volume: 6, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Oral; Animals; Antiparkinson Agents; Carbidopa; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Levodopa; Macaca mulatta; Neurologic Examination; Parkinson Disease, Secondary; Stereotyped Behavior

1991
Modulating role of dopamine on anesthetic requirements.
    European journal of pharmacology, 1990, Sep-04, Volume: 186, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Anesthesia; Animals; Benzamides; Benzazepines; Carbidopa; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Halothane; Kinetics; Levodopa; Mice; Mice, Inbred C57BL; Receptors, Dopamine

1990
The role of striatopallidal neurones utilizing gamma-aminobutyric acid in the pathophysiology of MPTP-induced parkinsonism in the primate: evidence from [3H]flunitrazepam autoradiography.
    Brain research, 1990, Oct-29, Volume: 531, Issue:1-2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain; Carbidopa; Corpus Striatum; Deoxyglucose; Flunitrazepam; gamma-Aminobutyric Acid; Globus Pallidus; Levodopa; Macaca fascicularis; Neurons; Organ Specificity; Parkinson Disease; Parkinson Disease, Secondary; Tritium

1990
Preliminary report on adrenal medullary grafting and cografting with sural nerve in the treatment of hemiparkinson monkeys.
    Progress in brain research, 1990, Volume: 82

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Medulla; Animals; Apomorphine; Behavior, Animal; Carbidopa; Caudate Nucleus; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Induced; Levodopa; Macaca mulatta; Motor Activity; Parkinson Disease; Sural Nerve; Transplantation, Heterotopic

1990
Determination of plasma [18F]-6-fluorodopa during positron emission tomography: elimination and metabolism in carbidopa treated subjects.
    Life sciences, 1986, Dec-08, Volume: 39, Issue:23

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dystonia; Humans; Kinetics; Metabolic Clearance Rate; Parkinson Disease; Pyridines; Tomography, Emission-Computed

1986
[A model of Parkinson's disease: effect of L-dopa therapy on movement parameters and electromyographic activity in monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1985, Volume: 179, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Carbidopa; Disease Models, Animal; Drug Combinations; Electromyography; Levodopa; Macaca mulatta; Movement Disorders; Parkinson Disease, Secondary; Pyridines

1985
Design and early clinical evaluation of selective inhibitors of monoamine oxidase.
    Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Allyl Compounds; Allylamine; Amines; Animals; Blood Platelets; Blood Pressure; Brain; Butylamines; Carbidopa; Dogs; Female; Heart Rate; Humans; In Vitro Techniques; Isoenzymes; Male; Methoxyhydroxyphenylglycol; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Pyridines; Rats; Rats, Inbred Strains; Serotonin; Tyramine

1988
Parkinson's disease.
    Comprehensive therapy, 1986, Volume: 12, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amantadine; Animals; Benserazide; Carbidopa; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Humans; Levodopa; Monoamine Oxidase Inhibitors; Parasympatholytics; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Rats

1986
Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
    Life sciences, 1986, Jul-07, Volume: 39, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Brain; Brain Chemistry; Carbidopa; Carotid Artery, Internal; Disease Models, Animal; Dominance, Cerebral; Dopamine; Homovanillic Acid; Injections, Intra-Arterial; Levodopa; Macaca fascicularis; Movement; Neurons; Parkinson Disease, Secondary; Pyridines

1986
Effect of increasing regimens of levodopa on chronic MPTP-induced parkinsonism in monkey; mechanographic and electromyographic data.
    Electromyography and clinical neurophysiology, 1986, Volume: 26, Issue:8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Carbidopa; Dose-Response Relationship, Drug; Drug Combinations; Electromyography; Levodopa; Macaca mulatta; Parkinson Disease, Secondary; Pyridines

1986
Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases.
    Neurology, 1985, Volume: 35, Issue:7

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acute Disease; Adult; Carbidopa; Chronic Disease; Drug Combinations; Female; Humans; Levodopa; Male; Parkinson Disease; Pyridines; Substance-Related Disorders; Substantia Nigra

1985
Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson's disease.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1984, Volume: 11, Issue:1 Suppl

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adult; Carbidopa; Drug Combinations; Female; Hallucinations; Humans; Levodopa; Male; Movement Disorders; Parkinson Disease; Parkinson Disease, Secondary; Pyridines

1984
Adrenal medulla and Parkinson's disease.
    Microscopy research and technique, 1994, Oct-01, Volume: 29, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Medulla; Animals; Carbidopa; Catecholamines; Disease Models, Animal; Drug Combinations; Humans; Levodopa; Male; Mice; Mice, Inbred C57BL; Parkinson Disease, Secondary

1994
Role of selective D1 and D2 agonists in inducing dyskinesia in drug-naive MPTP monkeys.
    Advances in neurology, 1993, Volume: 60

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Brain Mapping; Carbidopa; Corpus Striatum; Dopamine Agents; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Dyskinesia, Drug-Induced; Female; Levodopa; Locomotion; Macaca fascicularis; Parkinson Disease, Secondary; Psychomotor Performance; Receptors, Dopamine D1; Receptors, Dopamine D2

1993
Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease.
    Annals of neurology, 1994, Volume: 35, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetamides; Analysis of Variance; Animals; Anticonvulsants; Antiparkinson Agents; Brain; Carbidopa; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Levodopa; Macaca mulatta; Male; Motor Activity; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors

1994
Developing a stable bilateral model of parkinsonism in rhesus monkeys.
    Neuroscience, 1993, Volume: 52, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Carbidopa; Carotid Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Feeding Behavior; Female; Injections, Intra-Arterial; Levodopa; Macaca mulatta; Motor Activity; Parkinson Disease, Secondary

1993
Chronic L-DOPA administration induces dyskinesias in the 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-treated common marmoset (Callithrix Jacchus).
    Movement disorders : official journal of the Movement Disorder Society, 1995, Volume: 10, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Oral; Animals; Antiparkinson Agents; Callithrix; Carbidopa; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Neurologic Examination; Parkinson Disease, Secondary

1995
Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI.
    Magnetic resonance imaging, 1996, Volume: 14, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Mapping; Carbidopa; Female; Levodopa; Macaca mulatta; Magnetic Resonance Imaging; Parkinson Disease, Secondary

1996
(-)-OSU 6162 inhibits levodopa-induced dyskinesias in a monkey model of Parkinson's disease.
    Neuroreport, 1997, Jul-28, Volume: 8, Issue:11

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callithrix; Carbidopa; Dopamine Antagonists; Levodopa; Male; Motor Activity; Parkinson Disease, Secondary; Piperidines; Posture; Raclopride; Salicylamides

1997
Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys.
    Annals of neurology, 1997, Volume: 42, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Carbidopa; Cerebral Ventricles; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Female; Glial Cell Line-Derived Neurotrophic Factor; Injections, Intraventricular; Levodopa; Macaca mulatta; Motor Activity; Nerve Growth Factors; Nerve Tissue Proteins; Neuroprotective Agents; Parkinson Disease, Secondary; Stereotyped Behavior

1997
Entacapone enhances levodopa-induced reversal of motor disability in MPTP-treated common marmosets.
    Movement disorders : official journal of the Movement Disorder Society, 1997, Volume: 12, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callithrix; Carbidopa; Catechols; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Female; Levodopa; Male; Movement Disorders; Nitriles; Severity of Illness Index

1997
Principal component analysis of the dynamic response measured by fMRI: a generalized linear systems framework.
    Magnetic resonance imaging, 1999, Volume: 17, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Mapping; Carbidopa; Dopamine Agents; Female; Levodopa; Linear Models; Macaca mulatta; Magnetic Resonance Imaging; Mathematics; Models, Statistical; Parkinson Disease, Secondary; Regression Analysis; Systems Analysis

1999
Internal globus pallidus discharge is nearly suppressed during levodopa-induced dyskinesias.
    Annals of neurology, 1999, Volume: 46, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Carbidopa; Drug Combinations; Dyskinesia, Drug-Induced; Dyskinesias; Electrophysiology; Eye Movements; Globus Pallidus; Levodopa; Macaca mulatta; Motor Activity; Neurons; Parkinsonian Disorders

1999
Combined use of the adenosine A(2A) antagonist KW-6002 with L-DOPA or with selective D1 or D2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in MPTP-treated monkeys.
    Experimental neurology, 2000, Volume: 162, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Oral; Animals; Callithrix; Carbidopa; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Injections, Intraperitoneal; Levodopa; Male; Motor Activity; Parkinson Disease, Secondary; Purinergic P1 Receptor Antagonists; Purines; Quinpirole; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2

2000
Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach.
    Experimental neurology, 2000, Volume: 164, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aromatic-L-Amino-Acid Decarboxylases; Carbidopa; Catheterization; Caudate Nucleus; Cell Line; Dependovirus; Dopamine; Drug Administration Routes; Drug Combinations; Fluorine Radioisotopes; Genetic Therapy; Genetic Vectors; Levodopa; Macaca mulatta; Magnetic Resonance Imaging; Neurons; Parkinson Disease, Secondary; Prodrugs; Putamen; Tomography, Emission-Computed; Tyrosine; Tyrosine 3-Monooxygenase

2000
Dopamine replacement therapy reverses abnormal synchronization of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of parkinsonism.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Sep-15, Volume: 22, Issue:18

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Action Potentials; Animals; Antiparkinson Agents; Bromocriptine; Carbidopa; Chlorocebus aethiops; Disease Models, Animal; Dopamine; Dopamine Agonists; Drug Therapy, Combination; Electrodes, Implanted; Female; Globus Pallidus; Levodopa; Neurons; Organic Chemicals; Parkinsonian Disorders

2002
Effect of pulsatile administration of levodopa on dyskinesia induction in drug-naïve MPTP-treated common marmosets: effect of dose, frequency of administration, and brain exposure.
    Movement disorders : official journal of the Movement Disorder Society, 2003, Volume: 18, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Callithrix; Carbidopa; Catechols; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Levodopa; Locomotion; Male; Nitriles; Parkinsonian Disorders; Pulse Therapy, Drug; Substantia Nigra; Time Factors

2003
Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D3 receptor knockout mice.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 76, Issue:3-4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Autoradiography; Behavior, Animal; Benzopyrans; Carbidopa; Cocaine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Female; Grooming; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Nerve Tissue Proteins; Oxazines; Pyrroles; Radiopharmaceuticals; Receptors, Dopamine D2; Receptors, Dopamine D3; Stereotyped Behavior

2003
Multiple small doses of levodopa plus entacapone produce continuous dopaminergic stimulation and reduce dyskinesia induction in MPTP-treated drug-naive primates.
    Movement disorders : official journal of the Movement Disorder Society, 2005, Volume: 20, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Callithrix; Carbidopa; Catechols; Dopamine Agents; Drug Administration Schedule; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Injections, Subcutaneous; Levodopa; Locomotion; Male; MPTP Poisoning; Nitriles; Severity of Illness Index; Substantia Nigra; Time Factors

2005
The timing of administration, dose dependence and efficacy of dopa decarboxylase inhibitors on the reversal of motor disability produced by L-DOPA in the MPTP-treated common marmoset.
    European journal of pharmacology, 2010, Jun-10, Volume: 635, Issue:1-3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Callithrix; Carbidopa; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; Female; Levodopa; Male; Methyldopa; Motor Activity; Movement Disorders

2010
Linagliptin potentiates the effect of l-dopa on the behavioural, biochemical and immunohistochemical changes in experimentally-induced Parkinsonism: Role of toll-like receptor 4, TGF-β1, NF-κB and glucagon-like peptide 1.
    Physiology & behavior, 2018, 05-01, Volume: 188

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Carbidopa; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Glucagon-Like Peptide 1; Levodopa; Linagliptin; Mice; Mice, Inbred BALB C; NF-kappa B; Parkinsonian Disorders; Toll-Like Receptor 4; Transforming Growth Factor beta1

2018