Compounds > 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine
Page last updated: 2024-09-03

1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine has been researched along with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in 9 studies

Compound Research Comparison

Studies
(1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine)		Trials
(1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine)		Recent Studies (post-2010)
(1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine)		Studies
(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)		Trials
(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)		Recent Studies (post-2010) (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
9003,85981,052

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (44.44)18.2507
2000's5 (55.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrews, AM; Murphy, DL3
Andrews, AM; Cadet, JL; Epstein, CJ; Ladenheim, B; Murphy, DL1
Andrews, AM; Mazzola-Pomietto, P; Murphy, DL; Unger, EL1
Andrews, AM; Chisnell, AC; Luellen, BA; Miller, DB; Murphy, DL; O'Callaghan, JP1
Andrews, AM; Numis, AL; Szapacs, ME1
Andrews, AM; Chisnell, AC; Numis, AL; Sheridan, DL; Unger, EL1
Andrews, AM; Luellen, BA; Materese, CK; Szapacs, ME1

Other Studies

9 other study(ies) available for 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

ArticleYear
Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP.
    Journal of neurochemistry, 1993, Volume: 60, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cerebral Cortex; Corpus Striatum; Dopamine; Dopamine Agents; Hippocampus; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Serotonin; Tissue Distribution

1993
Fluoxetine and desipramine selectively attenuate 2'-NH2-MPTP-induced depletions in serotonin and norepinephrine.
    European journal of pharmacology, 1993, Dec-07, Volume: 250, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Body Temperature; Brain Chemistry; Carrier Proteins; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters

1993
2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neuro
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cerebral Cortex; Clorgyline; Desipramine; Fluoxetine; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; MPTP Poisoning; Neurotransmitter Uptake Inhibitors; Norepinephrine; Paroxetine; Selegiline; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Time Factors

1993
Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals.
    Molecular pharmacology, 1996, Volume: 50, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monoamine Oxidase; MPTP Poisoning; Nerve Endings; Norepinephrine; Serotonin; Superoxide Dismutase

1996
2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine].
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Body Temperature; Brain Chemistry; Carrier Proteins; Hydroxyindoleacetic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Plasma Membrane Transport Proteins

2002
Neuronal and astroglial responses to the serotonin and norepinephrine neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Brain Chemistry; Dopamine; Enzyme-Linked Immunosorbent Assay; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Male; Mice; Neostriatum; Neurons; Neurotoxins; Norepinephrine; Serotonin; Silver Staining; Tyrosine 3-Monooxygenase

2003
Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1.
    Neurobiology of disease, 2004, Volume: 16, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; Amyloid beta-Protein Precursor; Animals; Brain-Derived Neurotrophic Factor; Corpus Striatum; Dopamine; Hippocampus; Humans; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Mice, Transgenic; Norepinephrine; Presenilin-1; Serotonin

2004
The role of membrane and vesicular monoamine transporters in the neurotoxic and hypothermic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP).
    Molecular pharmacology, 2004, Volume: 66, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Body Temperature; Carrier Proteins; Gene Silencing; Hypothermia, Induced; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; MPTP Poisoning; Nerve Tissue Proteins; Neuropeptides; Serotonin; Serotonin Plasma Membrane Transport Proteins; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins

2004
The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF.
    Neuropharmacology, 2006, Volume: 50, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Axons; Biogenic Monoamines; Brain Chemistry; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Immunohistochemistry; Male; Mice; Nerve Degeneration; RNA, Messenger; Serotonin; Time Factors; Tyrosine 3-Monooxygenase

2006