1-methyl-3-isobutylxanthine has been researched along with zaprinast in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (15.15) | 18.7374 |
| 1990's | 36 (54.55) | 18.2507 |
| 2000's | 18 (27.27) | 29.6817 |
| 2010's | 2 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bristol, JA; Cain, MH; Weishaar, RE | 1 |
| Hughes, RA; Manallack, DT; Thompson, PE | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Gauthier, C; Le Bec, A; Lugnier, C; Soustre, H | 1 |
| Barbier, AJ; Lefebvre, RA | 2 |
| Donaldson, J; Hall, IP; Hill, SJ | 1 |
| Bolton, TB; Hering, S; Hughes, AD | 1 |
| Abdel-Aleem, S; Badr, M; Frangakis, C | 1 |
| Nunes, JP; Soares-da-Silva, P; Villanueva, MM | 1 |
| Chiba, S; Horiuchi, A; Iwatsuki, K; Ren, LM | 1 |
| Furchgott, RF; Jothianandan, D; Martin, W; Villani, GM | 1 |
| Le Bec, A; Lugnier, C; Schoeffter, P; Stoclet, JC; Strouthou, E | 1 |
| O'Donnell, ME; Owen, NE | 1 |
| Ignarro, LJ; Wood, KS | 1 |
| Lee, MA; Moss, J; West, RE | 1 |
| Brown, AM; Hill, SJ; Stanley, C | 1 |
| Brazdil, R; Diocee, BK; Jordan, R; Souness, JE | 1 |
| Clark, KL; Drew, GM; Hilditch, A | 1 |
| Fredholm, B; Sydbom, A; Uvnäs, B | 1 |
| Fujita, H; Kurahashi, K; Usui, H; Yoshikawa, M | 1 |
| de Vente, J; Sanders, KM; Shuttleworth, CW; Ward, SM; Xue, C | 1 |
| Dent, G; Magnussen, H; Nakashima, M; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Barnette, M; Grous, M | 1 |
| Osswald, W; Soares-da-Silva, P; Villanueva, MM | 1 |
| Fredholm, BB; Johansson, B; Svenningsson, P | 1 |
| Barnette, MS; Barone, FC; Manning, CD; Price, WJ | 1 |
| Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Furman, BL; Pyne, NJ; Shafiee-Nick, R | 1 |
| Chaudhuri, G; Chopra, M; Gryglewski, R; Ignarro, LJ; Radziszewski, W; Zembowicz, A | 1 |
| Hartell, NA | 1 |
| Couser, WG; Humphreys, MH; Ling, KT; Qiu, C; Sechi, LA; Valentin, JP; Ying, WZ | 1 |
| de Vente, J; Hopkins, DA; Markerink-van Ittersum, M; Steinbusch, HW | 1 |
| Cao, L; Cheng, Y; Gardner, DG; Humphreys, MH; Ni, X | 1 |
| Bakre, MM; Visweswariah, SS | 1 |
| Kaneda, T; Nakajyo, S; Shimizu, K; Urakawa, N | 1 |
| Horita, T; Kasugai, S; Miyamoto, K; Ohya, K; Waki, Y | 2 |
| Fabiano, C; Ientile, R; Macaione, S; Macaione, V; Pedale, S; Picciurro, V | 1 |
| Bina, S; Hart, JL; Muldoon, SM; Sei, Y | 1 |
| Conti, M; Hanssen, RG; Hirsch, B; Hsueh, AJ; Kloosterboer, HJ; Tsafriri, A; Van de Kant, M; Wiersma, A | 1 |
| Fagard, R; Lijnen, P; Petrov, V | 1 |
| Adcock, IM; Barnes, PJ; Robichaud, A; Seybold, J; Wright, LC | 1 |
| Gotow, T; Nishi, T | 1 |
| Hanni, KB; Keller, JN; Markesbery, WR; Mattson, MP | 1 |
| Fyhrquist, F; Saijonmaa, O | 1 |
| Cohen, RA; Griswold, MC; Komalavilas, P; Lincoln, TM; Weisbrod, RM; Yaghoubi, M | 1 |
| Gibson, A; O'Kane, K | 1 |
| Abdel-Wahab, YH; Ahmad, M; Flatt, PR; Furman, BL; Pyne, NJ; Tate, R | 1 |
| Goy, MF; Nandi, A; Prabhakar, S; Qian, X; Visweswariah, SS | 1 |
| Steinbusch, HW | 1 |
| Cherry, JA; Pho, V; Thompson, BE | 1 |
| Billah, MM; Egan, RW; Myers, JG; Stamford, A; Wang, P; Wu, P | 1 |
| Edvinsson, L; Jansen-Olesen, I; Khurana, TS; Kruuse, C; Olesen, J; Rybalkin, SD | 1 |
| D'Ocon, P; Ivorra, MD; Lugnier, C; Noguera, MA | 1 |
| Alarcón, C; Caballero-Plasencia, AM; Esteban, JM; Esteban, P; Herrerías, JM; Martín, J; Motilva, V; Valenzuela-Barranco, M | 1 |
| Delgado, M; Fernandez-Alfonso, MS; Fuentes, JA | 1 |
| Billah, MM; Egan, RW; Wang, P; Wu, P | 1 |
| Baltrons, MA; García, A; Navarra, M; Pedraza, CE; Sardón, T | 1 |
| Breese, E; Del Soldato, P; Mitchell, J; Warner, T; Wood, E; Zacharowski, P | 1 |
| Hoshi, M; Kawase, O; Matsumoto, M; Minakata, H; Ueno, S | 1 |
| Cia, D; Duboc, A; Forster, V; Gong, J; Jellali, A; Picaud, S; Sahel, JA; Tessier, LH; Vallazza-Deschamps, G | 1 |
| Prehm, P; Schulz, T; Schumacher, U | 1 |
| Barman, SA; White, RE; Zhu, S | 1 |
| Denda, M; Denda, S; Goto, M; Ikeyama, K; Tsutsumi, M | 1 |
| Hou, J; Ke, H; Liu, M; Luo, HB; Xu, J; Zhao, R | 1 |
2 review(s) available for 1-methyl-3-isobutylxanthine and zaprinast
| Article | Year |
|---|---|
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity | 1985 |
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines | 2005 |
64 other study(ies) available for 1-methyl-3-isobutylxanthine and zaprinast
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Chloride; Calmodulin; Chromatography, Ion Exchange; Cyclic GMP; Cytosol; Dipyridamole; Heart Atria; Heart Ventricles; Kinetics; Myocardium; Papaverine; Purinones; Pyrrolidinones; Rana esculenta; Rana ridibunda; Rolipram; Substrate Specificity; Theophylline | 1992 |
Effect of 3-isobutyl-1-methylxanthine and zaprinast on non-adrenergic non-cholinergic relaxation in the rat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Colforsin; Drug Interactions; Electric Stimulation; Female; Gastric Fundus; Male; Muscle Relaxation; Purinones; Rats; Rats, Inbred Strains | 1992 |
Modulation of carbachol-induced inositol phosphate formation in bovine tracheal smooth muscle by cyclic AMP phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Albuterol; Animals; Calcium; Carbachol; Cattle; Colforsin; Cyclic AMP; Drug Interactions; In Vitro Techniques; Inositol Phosphates; Male; Membrane Lipids; Muscle, Smooth; Phospholipids; Purinones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1990 |
The action of caffeine on inward barium current through voltage-dependent calcium channels in single rabbit ear artery cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Barium; Caffeine; Calcium Channels; Cell Membrane; Ear; Electric Conductivity; Female; Ion Channels; Male; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rabbits; Rolipram; Xanthines | 1990 |
Stimulation of fatty acid oxidation in myocytes by phosphodiesterase inhibitors and adenosine analogues.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Amrinone; Animals; Cells, Cultured; Dipyridamole; Enoximone; Heart; Imidazoles; Milrinone; Myocardium; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Phosphodiesterase Inhibitors; Purinones; Pyridazines; Pyridones; Rats | 1991 |
Relaxant effects of alpha-human atrial natriuretic peptide on venous smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Carbachol; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Peptide Fragments; Purinones; Saphenous Vein; Splenic Artery; Vasodilation | 1991 |
Effects of the cyclic nucleotide phosphodiesterase inhibitors, rolipram, 3-isobutyl-1-methylxanthine, amrinone and zaprinast, on pancreatic exocrine secretion in dogs.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amrinone; Animals; Bicarbonates; Cyclic AMP; Cyclic GMP; Dogs; Female; Male; Pancreas; Pancreatic Juice; Perfusion; Phosphodiesterase Inhibitors; Proteins; Purinones; Pyrrolidinones; Rolipram; Secretin; Sincalide | 1991 |
Phosphodiesterase inhibitors induce endothelium-dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cyclic GMP; Drug Synergism; Endothelium; Hemoglobins; In Vitro Techniques; Isoproterenol; Male; Nitric Oxide; Nitroglycerin; Papaverine; Phosphodiesterase Inhibitors; Purinones; Rabbits; Rats; Rats, Inbred Strains; Vasodilation; Vasodilator Agents | 1986 |
Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Cattle; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Humans; Kinetics; Muscle, Smooth, Vascular; Purinones; Rats; Species Specificity; Substrate Specificity | 1986 |
Role of cyclic GMP in atrial natriuretic factor stimulation of Na+,K+,Cl- cotransport in vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Aminoquinolines; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Carrier Proteins; Cyclic GMP; Muscle, Smooth, Vascular; Purinones; Rats; Sodium-Potassium-Chloride Symporters | 1986 |
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine | 1987 |
Atrial natriuretic factor reduces cyclic adenosine monophosphate content of human fibroblasts by enhancing phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylate Cyclase Toxin; Alprostadil; Atrial Natriuretic Factor; Cyclic AMP; Enzyme Activation; Fibroblasts; Humans; Isoproterenol; Pertussis Toxin; Purinones; Receptors, Cyclic AMP; Skin; Virulence Factors, Bordetella | 1988 |
Effect of isozyme-selective inhibitors of phosphodiesterase on histamine-stimulated cyclic AMP accumulation in guinea-pig hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cerebral Cortex; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine; Isoenzymes; Male; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1989 |
Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Kinetics; Male; Methylene Blue; Muscle Relaxants, Central; Nitric Oxide; Phthalazines; Purinones; Pyridazines; Rats; Rats, Inbred Strains; Theophylline; Vinca Alkaloids | 1989 |
Potentiation of the effects of dopamine in the rabbit isolated splenic artery by 3-isobutyl-1-methylxanthine or forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Benzopyrans; Colforsin; Cromakalim; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Male; Parasympatholytics; Purinergic Antagonists; Purinones; Pyrroles; Rabbits; Splenic Artery; Theophylline | 1989 |
Evidence against a role of cyclic nucleotides in the regulation of anaphylactic histamine release in isolated rat mast cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aza Compounds; Cyclic AMP; Cyclic GMP; Histamine Release; Male; Mast Cells; Purinones; Rats; Rats, Inbred Strains; Theophylline | 1981 |
Isolation and characterization of ovokinin, a bradykinin B1 agonist peptide derived from ovalbumin.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bradykinin; Dinoprost; Dogs; Dose-Response Relationship, Drug; Egg Proteins; In Vitro Techniques; Mesenteric Arteries; Molecular Sequence Data; Muscle Relaxation; Muscle, Smooth, Vascular; Ovalbumin; Papaverine; Peptide Fragments; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rolipram; Vasodilator Agents | 1995 |
Immunohistochemical localization of 3',5'-cyclic guanosine monophosphate in the canine proximal colon: responses to nitric oxide and electrical stimulation of enteric inhibitory neurons.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Colon; Cyclic GMP; Dogs; Electric Stimulation; Enteric Nervous System; Female; Ganglia, Autonomic; Male; Nitric Oxide; Nitroprusside; Purinones; Second Messenger Systems | 1993 |
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Antihypertensive Agents; Carbachol; Colforsin; Cytosol; Dinoprost; Dose-Response Relationship, Drug; Female; Humans; Isoenzymes; Kinetics; Lung Neoplasms; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Purinones; Pyridazines; Pyrrolidinones; Rolipram | 1994 |
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antigens; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Immunization; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1994 |
Effect of sympathetic denervation on the relaxing responses of rabbit arterial smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Colforsin; Cyclic AMP; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroprusside; Purinones; Rabbits; Sympathectomy, Chemical; Vasodilation | 1994 |
Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Female; Gastric Fundus; In Vitro Techniques; Isoenzymes; Male; Muscle Relaxation; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrrolidinones; Rolipram; Vasoactive Intestinal Peptide | 1995 |
Effect of different xanthines and phosphodiesterase inhibitors on c-fos expression in rat striatum.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Administration Schedule; In Situ Hybridization; Male; Neostriatum; Nicotinic Acids; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins c-fos; Purinones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Xanthines | 1995 |
Initial biochemical and functional characterization of cyclic nucleotide phosphodiesterase isozymes in canine colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Colforsin; Colon; Cyclic AMP; Cyclic GMP; Dogs; Isoenzymes; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rolipram | 1993 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity | 1993 |
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Thiophenes | 1995 |
Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Cells, Cultured; Culture Media; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; Guanylate Cyclase; Humans; Ion Transport; Molsidomine; Nitric Oxide; Ouabain; Penicillamine; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Probenecid; Prostaglandin D2; Prostaglandins; Prostaglandins A; Purinones; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase; Time Factors; Triazoles | 1995 |
Inhibition of cGMP breakdown promotes the induction of cerebellar long-term depression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cerebellum; Cyclic GMP; Dipyridamole; Long-Term Potentiation; Male; Phosphodiesterase Inhibitors; Purinones; Purkinje Cells; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
Phosphodiesterase inhibitors correct resistance to natriuretic peptides in rats with Heymann Nephritis.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Atrial Natriuretic Factor; Cyclic GMP; Diuretics; Glomerular Filtration Rate; Glomerulonephritis; In Vitro Techniques; Kidney Glomerulus; Kidney Tubules, Collecting; Male; Natriuresis; Peptide Fragments; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor | 1996 |
Effects of the 3',5'-phosphodiesterase inhibitors isobutylmethylxanthine and zaprinast on NO-mediated cGMP accumulation in the hippocampus slice preparation: an immunocytochemical study.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Hippocampus; Immunohistochemistry; Nitric Oxide; Organ Culture Techniques; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Inbred Strains | 1996 |
Mechanisms contributing to renal resistance to atrial natriuretic peptide in rats with common bile-duct ligation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Blood Volume; Common Bile Duct; Cyclic GMP; Drug Resistance; Kidney; Ligation; Liver Diseases; Male; Natriuresis; Nervous System; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley | 1996 |
Dual regulation of heat-stable enterotoxin-mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bacterial Toxins; Cell Line; Cell Membrane; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Guanylate Cyclase; Humans; Kinetics; Milrinone; Phenothiazines; Purinones; Pyridones | 1997 |
Effects of various selective phosphodiesterase inhibitors on muscle contractility in guinea pig ileal longitudinal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carbachol; Cell Membrane Permeability; Cyclic AMP; Cyclic GMP; Detergents; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Nitroprusside; Octoxynol; Phosphodiesterase Inhibitors; Potassium; Purinones; Type C Phospholipases; Vasodilator Agents | 1997 |
Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone Marrow Cells; Bone Resorption; Bucladesine; Calcification, Physiologic; Carcinoma 256, Walker; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Mice; Milrinone; Osteoclasts; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyridones; Rats; Rats, Wistar; Xanthines | 1997 |
Nitric oxide mediates NMDA-evoked [3H]GABA release from chick retina cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cells, Cultured; Chick Embryo; Cyclic GMP; Dizocilpine Maleate; gamma-Aminobutyric Acid; Isoquinolines; N-Methylaspartate; Nitric Oxide; Nitroarginine; Nitrogen Oxides; Purinones; Receptors, N-Methyl-D-Aspartate; Retina; Spermine; Tritium | 1997 |
Factors contributing to differences in the regulation of cGMP in isolated porcine pulmonary vessels.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Blotting, Western; Carbon Radioisotopes; Citrulline; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Guanylate Cyclase; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroarginine; Pulmonary Veins; Purinones; Swine | 1998 |
Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Contraceptive Agents, Female; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Estrus; Female; Fertilization; Heart Rate; Hypoxanthine; Isoenzymes; Meiosis; Menotropins; Mice; Mice, Inbred C57BL; Milrinone; Oogenesis; Ovarian Follicle; Ovulation; Ovulation Induction; Phosphodiesterase Inhibitors; Pregnancy; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Second Messenger Systems; Substrate Specificity; Thiophenes | 1998 |
Human erythrocytes contain Ca2+, calmodulin-dependent cyclic nucleotide phosphodiesterase which is involved in the hydrolysis of cGMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Calcium; Calmodulin; Cyclic GMP; Erythrocytes; Humans; Hydrolysis; Phosphodiesterase Inhibitors; Purinones; Sulfonamides; Vinca Alkaloids | 1998 |
Phosphodiesterase expression in human epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Cell Line; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 1; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Lung; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Thiophenes | 1998 |
Light-increased cGMP and K+ conductance in the hyperpolarizing receptor potential of Onchidium extra-ocular photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Abdomen; Aminoquinolines; Animals; Cyclic GMP; Electric Conductivity; Electrophysiology; Enzyme Inhibitors; Membrane Potentials; Mollusca; Phosphodiesterase Inhibitors; Photic Stimulation; Photoreceptor Cells, Invertebrate; Potassium; Purinones; Second Messenger Systems; Tetraethylammonium; Vision, Ocular | 1998 |
Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Aldehydes; Animals; Calcium; Cell Death; Cell Survival; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cysteine Proteinase Inhibitors; Lipid Peroxidation; Mitochondria; Neurons; Neurotoxins; PC12 Cells; Phosphodiesterase Inhibitors; Purinones; Rats; Reactive Oxygen Species | 1998 |
Upregulation of angiotensin converting enzyme by atrial natriuretic peptide and cyclic GMP in human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; Peptidyl-Dipeptidase A; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Purinones; Stimulation, Chemical; Thionucleotides; Umbilical Veins; Vasodilator Agents | 1998 |
Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Aorta; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Manganese; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinase C; Purinones; Quinoxalines; Rabbits; Thionucleotides; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
Effects of XT-44, a phosphodiesterase 4 inhibitor, in osteoblastgenesis and osteoclastgenesis in culture and its therapeutic effects in rat osteopenia models.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Bone Marrow Cells; Cyclic Nucleotide Phosphodiesterases, Type 4; Denervation; Dose-Response Relationship, Drug; Female; Femur; Giant Cells; Male; Mice; Osteoblasts; Osteoclasts; Osteogenesis; Ovariectomy; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Sciatic Nerve; Xanthines | 1999 |
Characterisation of nitrergic transmission in the isolated anococcygeus muscle of the female mouse.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catechols; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Estrus; Female; Guanylate Cyclase; In Vitro Techniques; Mice; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Synaptic Transmission; Vasoactive Intestinal Peptide; Vasodilator Agents | 1999 |
Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Base Sequence; Calcium; Calmodulin; Clone Cells; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Glucose; Humans; Insulin; Insulin Secretion; Insulin-Like Growth Factor I; Islets of Langerhans; Molecular Sequence Data; Phosphodiesterase Inhibitors; Purinones; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2000 |
Expression of GC-C, a receptor-guanylate cyclase, and its endogenous ligands uroguanylin and guanylin along the rostrocaudal axis of the intestine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoradiography; Binding Sites; Blotting, Western; Colon; Duodenum; Gastrointestinal Hormones; Guanylate Cyclase; Intestinal Mucosa; Ligands; Luminescent Measurements; Male; Natriuretic Peptides; Peptides; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; RNA, Messenger | 2000 |
The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Guanylate Cyclase; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Purinones; Radioimmunoassay; Rats; Signal Transduction | 2001 |
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diazepam; DNA, Complementary; Humans; Immunoblotting; Mice; Milrinone; Molecular Sequence Data; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rolipram; Sequence Homology, Amino Acid | 2001 |
Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Chromatography; Cyclic Nucleotide Phosphodiesterases, Type 5; Dipyridamole; Dogs; Humans; Isoenzymes; Kinetics; Male; Muscle, Smooth; Penis; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Purinones; Rabbits; Sildenafil Citrate; Species Specificity; Sulfones | 2001 |
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Milrinone; Nitroprusside; Oxadiazoles; Pentoxifylline; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Vasodilation; Vasodilator Agents | 2001 |
Role of cyclic nucleotide phosphodiesterase isoenzymes in contractile responses of denuded rat aorta related to various Ca2+ sources.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Aorta; Calcium; Isoenzymes; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Wistar; Rolipram; Vasoconstriction | 2001 |
Preventive effect of zaprinast and 3-isobutyl, 1-methylxanthine (phosphodiesterase inhibitors) on gastric injury induced by nonsteroidal antiinflammatory drugs in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Disease Models, Animal; Drug Interactions; Gastric Mucosa; Gastritis; Male; Phosphodiesterase Inhibitors; Primary Prevention; Purinones; Random Allocation; Rats; Rats, Wistar; Sensitivity and Specificity | 2003 |
Histamine up-regulates phosphodiesterase IV activity in U-937 cells through H2 receptor stimulation and cAMP increase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diphenhydramine; Guanidines; Histamine; Humans; Kinetics; Purinones; Pyridazines; Ranitidine; Receptors, Histamine H2; Rolipram; U937 Cells | 2003 |
Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Alternative Splicing; Amino Acid Sequence; Base Sequence; Blotting, Western; Cell Line; Cloning, Molecular; Cyclic GMP; DNA, Complementary; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Isoenzymes; Male; Molecular Sequence Data; Phosphodiesterase Inhibitors; Piperazines; Purines; Purinones; Recombinant Proteins; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Sildenafil Citrate; Sulfones | 2003 |
HIV-1 coat protein gp120 decreases NO-dependent cyclic GMP accumulation in rat brain astroglia by increasing cyclic GMP phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Astrocytes; Brain Chemistry; Cells, Cultured; Cyclic AMP; Flow Cytometry; Fluorescent Dyes; Guanylate Cyclase; HIV Envelope Protein gp120; Microglia; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2004 |
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Membrane Proteins; Naproxen; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Purinones; Synovial Membrane; Time Factors | 2005 |
Guanylyl cyclase and cGMP-specific phosphodiesterase participate in the acrosome reaction of starfish sperm.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Acrosome Reaction; Animals; Blotting, Western; Calcium; Electrophoresis, Polyacrylamide Gel; Guanylate Cyclase; Japan; Male; Purinones; Spermatozoa; Starfish; Tasmania | 2004 |
Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Blotting, Western; Cadmium Chloride; Calcium Channel Blockers; Cell Death; Cells, Cultured; Cyclic Nucleotide-Gated Cation Channels; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; In Situ Nick-End Labeling; In Vitro Techniques; Ion Channels; Mice; Mice, Mutant Strains; Nerve Degeneration; Neuroglia; Phosphodiesterase Inhibitors; Photoreceptor Cells; Purinones; Rats; Rats, Wistar; Swine; Verapamil | 2005 |
Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport; Cell Membrane; Cyclic GMP; Cytosol; Fibroblasts; Humans; Hyaluronic Acid; Models, Biological; Multidrug Resistance-Associated Proteins; NG-Nitroarginine Methyl Ester; Purinones; RNA Interference; Xanthines | 2007 |
Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Hypertension, Pulmonary; Milrinone; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Potassium Channels, Calcium-Activated; Protein Kinase C; Pulmonary Artery; Purinones; Rats; Vasoconstriction | 2008 |
Phosphodiesterase inhibitors block the acceleration of skin permeability barrier repair by red light.
Topics: 1-Methyl-3-isobutylxanthine; Acetone; Animals; Cyclic Nucleotide Phosphodiesterases, Type 6; Epidermis; Gene Expression; Hyperplasia; Male; Mice; Mice, Hairless; Naphthyridines; Permeability; Phosphodiesterase Inhibitors; Phototherapy; Purinones; Pyrimidines; Skin; Transducin; Water; Wound Healing | 2011 |
Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic acid, and role of the invariant glutamine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Glutamic Acid; Glutamine; Humans; Hydrogen Bonding; Kinetics; Molecular Dynamics Simulation; Mutation; Protein Structure, Secondary; Purinones; Structure-Activity Relationship | 2011 |