1-methyl-3-isobutylxanthine has been researched along with wortmannin in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 11 (57.89) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Arimura, S; Nakata, H; Nishio, E; Sasa, H; Tomiyama, K; Watanabe, Y | 1 |
| Bos, JL; Dorrestijn, J; Maassen, JA; Ouwens, DM; Van den Berghe, N | 1 |
| Earp, HS; Graves, LM; Li, X; Yu, H | 1 |
| Dunzendorfer, S; Kähler, CM; Reinisch, N; Schratzberger, P; Wiedermann, CJ | 1 |
| Carnero, A; Lacal, JC | 1 |
| Halbwachs-Mecarelli, L; Lesavre, P; Lopez, S; Robinson, MK; Seveau, S | 1 |
| Lu, D; Saito, I; Shibata, H; Takeuchi, T; Tamemoto, H | 1 |
| Adachi, T; Kagimoto, S; Kubota, A; Nunoi, K; Okamoto, Y; Seino, Y; Shihara, N; Tanaka, H; Tsuda, K; Uno, M; Xu, LM; Yamada, Y; Yasuda, K | 1 |
| Haruta, T; Iwata, M; Kawahara, J; Kobayashi, M; Sasaoka, T; Takano, A; Ueno, E; Uno, T; Usui, I | 1 |
| Byrnes, HD; Fine, JS; Hipkin, RW; Zavodny, PJ | 1 |
| Greenberg, AG; Kraemer, FB; Xue, B; Zemel, MB | 1 |
| Ammar, DA; Forte, JG; Yao, X; Zhou, R | 1 |
| Bazan, NG; Bernatchez, PN; Gélinas, DS; Rollin, S; Sirois, MG | 1 |
| Lee, JW; Romsos, DR; Swick, AG | 1 |
| Andersson, TP; Sköld, HN; Svensson, SP | 1 |
| Djanani, AM; Feistritzer, C; Kaneider, NC; Lindner, J; Mosheimer, BA; Sturn, DH; Wiedermann, CJ | 1 |
| Christensen, GP; Forte, JG; Ghayouri, S; Mettler, SE | 1 |
| Das, D; Khan, PP; Maitra, S | 1 |
19 other study(ies) available for 1-methyl-3-isobutylxanthine and wortmannin
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells.
Topics: 1-Methyl-3-isobutylxanthine; 1-Phosphatidylinositol 4-Kinase; 3T3 Cells; Adipocytes; Androstadienes; Animals; Cell Differentiation; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; Insulin; Mice; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Wortmannin | 1995 |
Expression of a dominant-negative Ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulin.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Androstadienes; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Deoxyglucose; Glycogen; Guanosine Diphosphate; Guanosine Triphosphate; Insulin; Insulin Antagonists; Kinetics; Mice; Mutagenesis; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Transfection; Wortmannin | 1996 |
Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; Liver; Mitogen-Activated Protein Kinases; Models, Biological; Polyenes; Protein Kinases; Rats; Recombinant Proteins; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Wortmannin | 1997 |
Secretoneurin, a novel neuropeptide, is a potent chemoattractant for human eosinophils.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Catechols; Chemotactic Factors; Chemotaxis; Enzyme Inhibitors; Eosinophils; Humans; Interleukin-8; Neuropeptides; Nitriles; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Protein-Tyrosine Kinases; Secretogranin II; Signal Transduction; Substance P; Tyrphostins; Wortmannin | 1998 |
Wortmannin, an inhibitor of phosphatidyl-inositol 3-kinase, induces oocyte maturation through a MPF-MAPK-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Cycloheximide; Enzyme Activation; Enzyme Inhibitors; Female; In Vitro Techniques; Kinetics; Maturation-Promoting Factor; Morpholines; Oocytes; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Wortmannin; Xenopus laevis | 1998 |
CD43 (sialophorin, leukosialin) shedding is an initial event during neutrophil migration, which could be closely related to the spreading of adherent cells.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Antibodies, Monoclonal; Antigens, CD; Bucladesine; CD18 Antigens; Cell Adhesion; Cell Size; Cells, Cultured; Chemotaxis, Leukocyte; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Edetic Acid; Endothelium, Vascular; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation; Genistein; Humans; Leukosialin; Manganese; Neutrophils; Sialoglycoproteins; Signal Transduction; Stress, Mechanical; Tumor Necrosis Factor-alpha; Umbilical Veins; Wortmannin | 1998 |
Regulatable production of insulin from primary-cultured hepatocytes: insulin production is up-regulated by glucagon and cAMP and down-regulated by insulin.
Topics: 1-Methyl-3-isobutylxanthine; Adenoviridae; Androstadienes; Animals; Cells, Cultured; Cyclic AMP; Gene Expression Regulation; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Glucagon; Insulin; Insulin Antagonists; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Proinsulin; Rats; Rats, Wistar; Wortmannin | 1998 |
Wortmannin, a PI3-kinase inhibitor: promoting effect on insulin secretion from pancreatic beta cells through a cAMP-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Colforsin; Cyclic AMP; Enzyme Inhibitors; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Perfusion; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Wistar; Signal Transduction; Wortmannin | 2000 |
Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Androstadienes; Animals; Cell Differentiation; Clone Cells; Dexamethasone; Flavonoids; Insulin; Insulin Antagonists; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Retinoblastoma Protein; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2000 |
Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Colforsin; Flavonoids; Humans; In Vitro Techniques; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Signal Transduction; Wortmannin | 2001 |
Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Androstadienes; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Humans; Insulin; Isoproterenol; Lipolysis; Phosphodiesterase Inhibitors; Phosphorylation; Potassium Chloride; Quinolones; Sterol Esterase; Wortmannin; Xanthines | 2001 |
Syntaxin 3 is required for cAMP-induced acid secretion: streptolysin O-permeabilized gastric gland model.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Adenosine Triphosphate; Aminopyrine; Androstadienes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bacterial Proteins; Bucladesine; Carbon Radioisotopes; Cell Membrane Permeability; Cyclic AMP; Cytoskeletal Proteins; Gastric Acid; Gastric Mucosa; Glutathione Transferase; H(+)-K(+)-Exchanging ATPase; Membrane Fusion; Membrane Proteins; Phosphodiesterase Inhibitors; Phosphoproteins; Pyridines; Qa-SNARE Proteins; Rabbits; SNARE Proteins; Streptolysins; Thiazoles; Vesicular Transport Proteins; Wortmannin | 2002 |
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2002 |
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin | 2003 |
Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Androstadienes; Animals; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Kinetics; Melanocyte-Stimulating Hormones; Melanophores; Melanosomes; Melatonin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Norepinephrine; Papaverine; Perciformes; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Rolipram; Signal Transduction; Wortmannin; Xenopus laevis | 2003 |
The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
Topics: 1-Methyl-3-isobutylxanthine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Androstadienes; Bombesin; Calcitonin Gene-Related Peptide; Cell Movement; Chemotaxis, Leukocyte; Cholera Toxin; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fingolimod Hydrochloride; Gene Expression Regulation; Heterotrimeric GTP-Binding Proteins; Humans; Immunologic Factors; Indoles; Leukocytes, Mononuclear; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neuropeptides; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Receptors, Lysosphingolipid; RNA, Messenger; Secretogranin II; Sphingosine; Staurosporine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin | 2004 |
Modulatory role of phosphoinositide 3-kinase in gastric acid secretion.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Androstadienes; Animals; Carbachol; Cell Shape; Cells, Cultured; Cholinergic Agonists; Chromones; Cyclic AMP; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Morpholines; Mutation; Organ Culture Techniques; Parietal Cells, Gastric; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidinones; Rabbits; Receptors, Histamine H2; Signal Transduction; Time Factors; Transduction, Genetic; Wortmannin | 2007 |
Participation of PI3-kinase/Akt signalling in insulin stimulation of p34cdc2 activation in zebrafish oocyte: phosphodiesterase 3 as a potential downstream target.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Chromones; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Female; Gene Expression Regulation, Developmental; Hydroxyprogesterones; Insulin; Isoenzymes; Meiosis; Morpholines; Oocytes; Phosphatidylinositol 3-Kinase; Phosphodiesterase 3 Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinolones; Recombinant Proteins; Signal Transduction; Wortmannin; Zebrafish | 2013 |