1-methyl-3-isobutylxanthine and vardenafil dihydrochloride

1-methyl-3-isobutylxanthine has been researched along with vardenafil dihydrochloride in 2 studies

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Corbin, JD; Francis, SH; Zoraghi, R	2

Other Studies

2 other study(ies) available for 1-methyl-3-isobutylxanthine and vardenafil dihydrochloride

Article	Year
Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity. The Journal of biological chemistry, 2006, Mar-03, Volume: 281, Issue:9 Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Glutamine; Humans; Imidazoles; Molecular Structure; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Protein Conformation; Purines; Sildenafil Citrate; Substrate Specificity; Sulfones; Triazines; Vardenafil Dihydrochloride	2006
Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors. Biochemistry, 2007, Nov-27, Volume: 46, Issue:47 Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Binding Sites; Carbolines; Catalytic Domain; Crystallography, X-Ray; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Histidine; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Kinetics; Molecular Sequence Data; Mutation; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Sequence Alignment; Sildenafil Citrate; Sulfones; Tadalafil; Thermodynamics; Triazines; Tyrosine; Vardenafil Dihydrochloride	2007

Article

Year

Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity.

The Journal of biological chemistry, 2006, Mar-03, Volume: 281, Issue:9

Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Glutamine; Humans; Imidazoles; Molecular Structure; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Protein Conformation; Purines; Sildenafil Citrate; Substrate Specificity; Sulfones; Triazines; Vardenafil Dihydrochloride

2006

Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors.

Biochemistry, 2007, Nov-27, Volume: 46, Issue:47

Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Binding Sites; Carbolines; Catalytic Domain; Crystallography, X-Ray; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Histidine; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Kinetics; Molecular Sequence Data; Mutation; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Sequence Alignment; Sildenafil Citrate; Sulfones; Tadalafil; Thermodynamics; Triazines; Tyrosine; Vardenafil Dihydrochloride

2007