1-methyl-3-isobutylxanthine has been researched along with rolipram in 104 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (13.46) | 18.7374 |
| 1990's | 52 (50.00) | 18.2507 |
| 2000's | 25 (24.04) | 29.6817 |
| 2010's | 11 (10.58) | 24.3611 |
| 2020's | 2 (1.92) | 2.80 |
| Authors | Studies |
|---|---|
| Browne, RG; Howard, HR; Koe, BK; Lebel, LA; Sarges, R; Seymour, PA | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bristol, JA; Cain, MH; Weishaar, RE | 1 |
| Hughes, RA; Manallack, DT; Thompson, PE | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Chen, G; Ke, H; Kunz, S; Martinelli, S; Robinson, H; Seebeck, T; Wan, Y; Wang, H | 1 |
| de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R | 1 |
| Bucki, A; Chłoń-Rzepa, G; Gawalska, A; Jankowska, A; Kołaczkowski, M; Pawłowski, M; Pociecha, K; Ślusarczyk, M; Świerczek, A; Wyska, E | 1 |
| Bucki, A; Chłoń-Rzepa, G; Gawalska, A; Jankowska, A; Kazek, G; Kołaczkowski, M; Pawłowski, M; Pociecha, K; Sałat, K; Ślusarczyk, M; Świerczek, A; Wyska, E; Zygmunt, M | 1 |
| Berk, B; Biltekin, SN; Demirayak, Ş; Gao, ZG; Jacobson, KA; Özhan, Y; Sahin, Z; Sipahi, H; Yurttas, L | 1 |
| Endoh, M; Katano, Y | 1 |
| Altiok, N; Fredholm, BB | 2 |
| Balcarek, JM; Chilton, FH; Livi, GP; Torphy, TJ; Undem, BJ; White, JR | 1 |
| Gauthier, C; Le Bec, A; Lugnier, C; Soustre, H | 1 |
| Bethke, T; Meyer, W; Schmitz, W; Scholz, H; Stein, B; Thomas, K; Wenzlaff, H | 1 |
| Donaldson, J; Hall, IP; Hill, SJ | 1 |
| Devall, LJ; Klinkefus, BA; Kobylarz-Singer, D; Kuipers, PJ; Weishaar, RE; Wright, CD | 1 |
| Bolton, TB; Hering, S; Hughes, AD | 1 |
| Nicholson, CD; Shahid, M | 1 |
| Rapoport, RM | 1 |
| Nicholson, D; Sawynok, J; White, TD | 1 |
| Levine, JD; Taiwo, YO | 1 |
| Gaal, L; Illes, P; Schudt, C | 1 |
| Sadler, SE | 1 |
| Chiba, S; Horiuchi, A; Iwatsuki, K; Ren, LM | 1 |
| Mulder, AH; Schoffelmeer, AN; Wierenga, EA | 1 |
| Fredholm, BB; Lerner, U; Ransjö, M | 1 |
| Luscombe, DK; Mustafa, MR; Stolz, JF | 1 |
| Fredholm, BB; Lerner, UH; Ransjö, M | 1 |
| Brown, AM; Hill, SJ; Stanley, C | 1 |
| Koch, B; Lutz-Bucher, B | 2 |
| Cottney, J; Marsden, G; Nicholson, CD; Shahid, M | 1 |
| Hertting, G; Jackisch, R; Kasakov, L; Strittmatter, H | 1 |
| Przegaliński, E; Rawłów, A | 1 |
| Wachtel, H | 2 |
| Schneider, HH | 1 |
| Fujita, H; Kurahashi, K; Usui, H; Yoshikawa, M | 1 |
| Fukui, S; Hashimoto, K; Inada, T; Iyo, M; Sasaki, H | 1 |
| Colicelli, J; Kytle, K; Pillai, R; Reyes, A | 1 |
| Botana, LM; MacGlashan, DW | 1 |
| Dent, G; Magnussen, H; Nakashima, M; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Barnette, M; Grous, M | 1 |
| Akita, T; Hartzell, HC; Joyner, RW; Kumar, R; Lu, C | 1 |
| Arauz, E; Fitzpatrick, DF; Krzanowski, JJ; Pan, X; Polson, JB | 1 |
| Amirchetty-Rao, S; Kendall, DA; Wright, IK | 1 |
| Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M | 1 |
| Brown, N; Houslay, MD; Sullivan, M; Wilson, M | 1 |
| Hatzelmann, A; Schudt, C; Tenor, H | 1 |
| Barbier, AJ; Lefebvre, RA | 1 |
| Fredholm, BB; Johansson, B; Svenningsson, P | 1 |
| Barnette, MS; Barone, FC; Manning, CD; Price, WJ | 1 |
| Schudt, C; Sybrecht, GW; Ukena, D | 1 |
| Dent, G; Liebig, S; Magnussen, H; Rabe, KF; Schudt, C; Tenor, H | 1 |
| Houslay, MD; Pryde, JG; Shakur, Y | 1 |
| Challiss, RA; Morgan, AJ; Murray, KJ | 1 |
| Akaike, N; Kawa, K; Uneyama, H; Yamashita, Y | 1 |
| Furman, BL; Pyne, NJ; Shafiee-Nick, R | 1 |
| Azizeh, BY; Houslay, MD; Hruby, VJ; Johnson, DG; Phelps, JR; Trivedi, D; Van Tine, BA | 1 |
| Evans, CJ; Gylys, KH; Magendzo, K; Tran, N; Zaki, P | 1 |
| Agematsu, K; Hu, B; Komiyama, A; Nakazawa, T; Yasui, K | 1 |
| Poduslo, JF; Walikonis, RS | 1 |
| Götz, KH; Hamann, M; Kurtz, A; Wagner, C | 1 |
| Conti, M; Hanssen, RG; Hirsch, B; Hsueh, AJ; Kloosterboer, HJ; Tsafriri, A; Van de Kant, M; Wiersma, A | 1 |
| Majluf-Cruz, A; Omburo, GA; Zhu, WH | 1 |
| Adcock, IM; Barnes, PJ; Robichaud, A; Seybold, J; Wright, LC | 1 |
| Mercurio, AM; O'Connor, KL; Shaw, LM | 1 |
| Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M | 1 |
| Horita, T; Kasugai, S; Miyamoto, K; Ohya, K; Waki, Y | 1 |
| Keravis, T; Le Bec, A; Lugnier, C; Pauvert, O; Proteau, S; Rousseau, E | 1 |
| Dormer, RL; Lloyd Mills, C; McPherson, MA; Murray, KJ; Pereira, MM | 1 |
| Jankovic, V; Maksimovic, D; Samardzic, T; Stosic-Grujicic, S; Trajkovic, V | 1 |
| Giovanni, A; Wirtz-Brugger, F | 1 |
| Branscheid, D; Dent, G; Magnussen, H; Rabe, KF; Rühlmann, E; Schmidt, DT; Watson, N | 1 |
| Cherry, JA; Pho, V; Thompson, BE | 1 |
| D'Ocon, P; Ivorra, MD; Lugnier, C; Noguera, MA | 1 |
| Kambayashi, T; Ljunggren, HG; Wallin, RP | 1 |
| Ang, KL; Antoni, FA | 1 |
| Dortch-Carnes, J; Potter, DE | 1 |
| Alkhalaf, M; El-Mowafy, AM | 1 |
| Baillie, GS; Bolger, GB; Houslay, MD; Huston, E; MacKenzie, C; McEwan, DG; Peden, AH; Steele, MR; Wallace, DA | 1 |
| Delgado, M; Fernandez-Alfonso, MS; Fuentes, JA | 1 |
| Andersson, TP; Sköld, HN; Svensson, SP | 1 |
| Baum, M; Chakravarty, S; Quigley, R | 1 |
| Fleming, YM; Frame, MC; Houslay, MD | 1 |
| Bhattacharjee, S; Haynes-Johnson, D; Kraft, PJ; Lundeen, SG; Qiu, Y | 1 |
| Kyoi, T; Noda, K; Oka, M; Ukai, Y | 1 |
| Huai, Q; Ke, H; Xu, RX | 1 |
| Alvarez, E; Cairrão, E; Morgado, M; Santos-Silva, AJ; Verde, I | 1 |
| Aandahl, EM; Aukrust, P; Bryn, T; Frøland, SS; Mahic, M; Taskén, K | 1 |
| Carabelli, V; Carbone, E; Comunanza, V; Marcantoni, A; Vandael, DH | 1 |
| Sosroseno, W; Sugiatno, E | 1 |
| Dorin, JR; Jackson, IJ; Lundegaard, PR; Patton, EE; Porteous, DJ; Reynolds, NL; Richardson, J | 1 |
| Batuca, JR; Monteiro, EC; Nunes, AR | 1 |
| Chen, ZY; Huang, Y; Lau, CW; Leung, FP; Liu, CQ; Lu, L; Tian, XY; Wong, SL; Yao, T; Yao, X | 1 |
| Aihara, E; Honda, M; Ito, Y; Kato, S; Mitsufuji, S; Okuda, S; Takeuchi, K; Yoshikawa, T | 1 |
| Bulaeva, SV; Miloradov, MJ; Muravyov, AV; Tikhomirova, IA; Uzikova, EV; Zamishlayev, AV | 1 |
| Kim, HM; Lee, GH; Lee, JW; Lee, MS; Moon, EY | 1 |
| Geras-Raaka, E; Gershengorn, MC; Neumann, S | 1 |
| de Seigneux, S; Derouette, JP; Dizin, E; Féraille, E; Hasler, U; Martin, PY; Roth, I; Szanto, I | 1 |
| Andric, N; Kopitovic, V; Pogrmic-Majkic, K; Samardzija, D; Stojkov-Mimic, N; Trninic-Pjevic, A; Vukosavljevic, J | 1 |
| Alvarez, DF; Annamdevula, N; Audia, JP; Britain, A; Dunbar, G; Hardy, KS; Housley, N; Leavesley, S; Renema, P; Rich, T; Spadafora, D | 1 |
3 review(s) available for 1-methyl-3-isobutylxanthine and rolipram
| Article | Year |
|---|---|
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity | 1985 |
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines | 2005 |
Therapeutic potential of isozyme-selective phosphodiesterase inhibitors in the treatment of asthma.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Asthma; Colforsin; Cyclic AMP; Humans; Mast Cells; Mice; Pyrrolidinones; Rolipram | 1992 |
1 trial(s) available for 1-methyl-3-isobutylxanthine and rolipram
| Article | Year |
|---|---|
Macro- and microrheological parameters of blood in patients with cerebral and peripheral atherosclerosis: the molecular change mechanisms after pentoxifylline treatment.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Anemia; Blood Transfusion; Erythrocytes; Erythropoietin; Female; Hemorheology; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Organoplatinum Compounds; Pentoxifylline; Peripheral Arterial Disease; Phosphodiesterase Inhibitors; Prospective Studies; Recombinant Proteins; Rolipram; Vinca Alkaloids; Young Adult | 2011 |
100 other study(ies) available for 1-methyl-3-isobutylxanthine and rolipram
| Article | Year |
|---|---|
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Cats; Cell Membrane; Cerebral Cortex; Chemical Phenomena; Chemistry; Corpus Striatum; Male; Molecular Structure; Motor Activity; Purinergic Antagonists; Quinoxalines; Rats; Receptors, Purinergic; Sleep; Structure-Activity Relationship; Triazoles | 1990 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Design; Kinetics; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sulfonamides; Surface Properties; Trypanosoma cruzi | 2012 |
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship | 2016 |
Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanes; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 7; Dose-Response Relationship, Drug; Drug Design; Endotoxemia; Humans; Hydrazines; Lipopolysaccharides; Male; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Wistar; Structure-Activity Relationship | 2018 |
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
Topics: Amides; Analgesics; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 7; Hyperalgesia; Male; Mice; Molecular Docking Simulation; Pain; Pain Measurement; Peripheral Nervous System Diseases; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats, Wistar; TRPA1 Cation Channel | 2018 |
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition.
Topics: Antineoplastic Agents; Binding Sites; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytosine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Molecular Structure; Phosphodiesterase 4 Inhibitors; Receptors, Purinergic P1; Structure-Activity Relationship; Thiouracil | 2021 |
Effects of a cardiotonic quinolinone derivative Y-20487 on the isoproterenol-induced positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: comparison with rolipram, Ro 20-1724, milrinone, and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram; Stimulation, Chemical; Thiadiazines | 1992 |
Bradykinin inhibition of cyclic AMP accumulation in D384 astrocytoma cells. Evidence against a role of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Arginine; Astrocytoma; Bradykinin; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Hydroxylamine; Hydroxylamines; Kinetics; NG-Nitroarginine Methyl Ester; Nitroprusside; Pyrrolidinones; Rolipram; Tumor Cells, Cultured | 1992 |
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Chloride; Calmodulin; Chromatography, Ion Exchange; Cyclic GMP; Cytosol; Dipyridamole; Heart Atria; Heart Ventricles; Kinetics; Myocardium; Papaverine; Purinones; Pyrrolidinones; Rana esculenta; Rana ridibunda; Rolipram; Substrate Specificity; Theophylline | 1992 |
Phosphodiesterase inhibition in ventricular cardiomyocytes from guinea-pig hearts.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Chromatography, Ion Exchange; Cyclic AMP; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Isoenzymes; Myocardium; Phosphodiesterase Inhibitors; Pyridazines; Pyrrolidinones; Rolipram | 1992 |
Modulation of carbachol-induced inositol phosphate formation in bovine tracheal smooth muscle by cyclic AMP phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Albuterol; Animals; Calcium; Carbachol; Cattle; Colforsin; Cyclic AMP; Drug Interactions; In Vitro Techniques; Inositol Phosphates; Male; Membrane Lipids; Muscle, Smooth; Phospholipids; Purinones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1990 |
Differential inhibition of human neutrophil functions. Role of cyclic AMP-specific, cyclic GMP-insensitive phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Humans; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram | 1990 |
The action of caffeine on inward barium current through voltage-dependent calcium channels in single rabbit ear artery cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Barium; Caffeine; Calcium Channels; Cell Membrane; Ear; Electric Conductivity; Female; Ion Channels; Male; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rabbits; Rolipram; Xanthines | 1990 |
Comparison of cyclic nucleotide phosphodiesterase isoenzymes in rat and rabbit ventricular myocardium: positive inotropic and phosphodiesterase inhibitory effects of Org 30029, milrinone and rolipram.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cardiotonic Agents; Heart; Heart Ventricles; Isoenzymes; Male; Milrinone; Myocardial Contraction; Myocardium; Organic Chemicals; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rabbits; Rats; Rats, Inbred Strains; Rolipram | 1990 |
Inhibitory effects of cyclic AMP-elevating agents on norepinephrine-induced phosphatidylinositide hydrolysis and contraction in rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Bucladesine; Cyclic AMP; Hydrolysis; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phosphatidylglycerols; Phosphatidylinositols; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram | 1991 |
Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 5'-Nucleotidase; Adenosine; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Morphine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rolipram; Spinal Cord; Synaptosomes | 1991 |
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dinoprostone; Epoprostenol; Hyperalgesia; Male; Phosphorylation; Protein Kinases; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Second Messenger Systems; Sensory Thresholds; Thionucleotides | 1991 |
Effects of phosphodiesterase inhibition on the excitability of hippocampal pyramidal neurons in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Isoproterenol; Male; Neurons; Phosphodiesterase Inhibitors; Pyramidal Tracts; Pyridazines; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram | 1991 |
Inhibitors of phosphodiesterase III block stimulation of Xenopus laevis oocyte ribosomal S6 kinase activity by insulin-like growth factor-I.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cricetinae; Female; Insulin-Like Growth Factor I; Meiosis; Oocytes; Oogenesis; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyridazines; Pyrrolidinones; Ribosomal Protein S6 Kinases; Rolipram; Theophylline; Xenopus laevis | 1991 |
Effects of the cyclic nucleotide phosphodiesterase inhibitors, rolipram, 3-isobutyl-1-methylxanthine, amrinone and zaprinast, on pancreatic exocrine secretion in dogs.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amrinone; Animals; Bicarbonates; Cyclic AMP; Cyclic GMP; Dogs; Female; Male; Pancreas; Pancreatic Juice; Perfusion; Phosphodiesterase Inhibitors; Proteins; Purinones; Pyrrolidinones; Rolipram; Secretin; Sincalide | 1991 |
Role of adenylate cyclase in presynaptic alpha 2-adrenoceptor- and mu-opioid receptor-mediated inhibition of [3H]noradrenaline release from rat brain cortex slices.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Cadmium; Calcimycin; Cerebral Cortex; Clonidine; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Norepinephrine; Phentolamine; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Rolipram | 1986 |
Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone and Bones; Bone Resorption; Calcium; Colforsin; Cyclic AMP; Dinoprostone; In Vitro Techniques; Indomethacin; Kinetics; Lysosomes; Mice; Parathyroid Hormone; Prostaglandins E; Pyrrolidinones; Rolipram; Theophylline | 1986 |
Effect of long-term rolipram administration on the sensitivity of alpha 2-adrenoceptors in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Clonidine; Desipramine; Drug Administration Schedule; Locomotion; Male; Phosphodiesterase Inhibitors; Pyrimidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Rolipram | 1988 |
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Bone Resorption; Calcium; Cells, Cultured; Cholera Toxin; Cyclic AMP; Hydrocortisone; Indomethacin; Meclofenamic Acid; Mice; Mice, Inbred Strains; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Skull; Theophylline | 1988 |
Effect of isozyme-selective inhibitors of phosphodiesterase on histamine-stimulated cyclic AMP accumulation in guinea-pig hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cerebral Cortex; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine; Isoenzymes; Male; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1989 |
Indirect relationship between vasopressin-induced secretion of ACTH and cyclic nucleotides in cultured anterior pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adrenocorticotropic Hormone; Animals; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Pituitary Gland, Anterior; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Vasopressins | 1989 |
A comparison of the inotropic activity of Org 30029, IBMX, milrinone and rolipram in rat papillary muscles.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cardiotonic Agents; In Vitro Techniques; Milrinone; Myocardial Contraction; Organic Chemicals; Papillary Muscles; Pyridones; Pyrrolidinones; Rats; Rolipram; Theophylline | 1989 |
Endogenous adenosine as a modulator of hippocampal acetylcholine release.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenosine; Animals; Caudate Nucleus; Dipyridamole; Electric Stimulation; Hippocampus; In Vitro Techniques; Pyrrolidinones; Rabbits; Receptors, Cell Surface; Receptors, Purinergic; Rolipram; Theophylline | 1984 |
The stimulatory action of phosphodiesterase inhibitors on the flexor reflex of the hind limb in the spinal rat.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Drug Interactions; Male; Phenoxybenzamine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Reflex; Rolipram; Spinal Cord; Theophylline | 1982 |
Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3', 5'-monophosphate phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Behavior, Animal; Body Temperature; Bucladesine; Imidazoles; Male; Motor Activity; Pyrimidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram | 1982 |
Species differences in behavioural effects of rolipram and other adenosine cyclic 3H, 5H-monophosphate phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Behavior, Animal; Body Temperature Regulation; Cyclic AMP; Dose-Response Relationship, Drug; Grooming; Guinea Pigs; Male; Motor Activity; Muridae; Muscle Contraction; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Species Specificity | 1983 |
Brain cAMP response to phosphodiesterase inhibitors in rats killed by microwave irradiation or decapitation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Brain Chemistry; Cyclic AMP; Male; Microwaves; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Time Factors | 1984 |
Isolation and characterization of ovokinin, a bradykinin B1 agonist peptide derived from ovalbumin.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bradykinin; Dinoprost; Dogs; Dose-Response Relationship, Drug; Egg Proteins; In Vitro Techniques; Mesenteric Arteries; Molecular Sequence Data; Muscle Relaxation; Muscle, Smooth, Vascular; Ovalbumin; Papaverine; Peptide Fragments; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rolipram; Vasodilator Agents | 1995 |
Suppression of oro-facial movements by rolipram, a cAMP phosphodiesterase inhibitor, in rats chronically treated with haloperidol.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antipsychotic Agents; Depression, Chemical; Dopamine Antagonists; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Haloperidol; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram | 1995 |
Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Base Sequence; Cloning, Molecular; DNA Primers; Drug Resistance; Kinetics; Mammals; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Point Mutation; Polymerase Chain Reaction; Pyrrolidinones; Rats; Recombinant Proteins; Rolipram | 1993 |
Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Basophils; Calcium; Colforsin; Cyclic AMP; Cytosol; Fluorescent Dyes; Fura-2; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Kinetics; Leukotrienes; Microscopy, Fluorescence; N-Formylmethionine Leucyl-Phenylalanine; Pyrrolidinones; Rolipram; Time Factors | 1994 |
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Antihypertensive Agents; Carbachol; Colforsin; Cytosol; Dinoprost; Dose-Response Relationship, Drug; Female; Humans; Isoenzymes; Kinetics; Lung Neoplasms; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Purinones; Pyridazines; Pyrrolidinones; Rolipram | 1994 |
Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antigens; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Immunization; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyrrolidinones; Rolipram | 1994 |
Developmental changes in modulation of calcium currents of rabbit ventricular cells by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Female; Isoproterenol; Male; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rabbits; Rolipram; Ventricular Function | 1994 |
Synergistic interactions between selective pharmacological inhibitors of phosphodiesterase isozyme families PDE III and PDE IV to attenuate proliferation of rat vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Cell Line; Drug Synergism; Isoenzymes; Models, Chemical; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyrrolidinones; Quinolones; Rats; Rolipram; Thymidine | 1994 |
Potentiation by forskolin of both SNP- and ANP-stimulated cyclic GMP accumulation in porcine isolated palmar lateral vein.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Colforsin; Cyclic GMP; Drug Synergism; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroprusside; Pyrrolidinones; Rolipram; Veins | 1994 |
[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cell Line; Cell Membrane; Cyclic AMP; Cytosol; Glioma; Kinetics; Mice; Neuroblastoma; Neuroglia; Neurons; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rats; Rolipram; Tritium; Tumor Cells, Cultured | 1994 |
Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Base Sequence; Cyclic AMP; Edetic Acid; Enzyme Stability; Hot Temperature; Humans; Hydrolysis; Kinetics; Magnesium; Manganese; Molecular Sequence Data; Molecular Weight; Pyrrolidinones; Recombinant Proteins; Rolipram; Saccharomyces cerevisiae | 1994 |
Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Benzamides; Blood Proteins; Cell Separation; Complement C5a; Cyclic Nucleotide Phosphodiesterases, Type 4; Electromagnetic Fields; Eosinophil Granule Proteins; Eosinophil-Derived Neurotoxin; Eosinophils; Humans; Inflammation Mediators; Luminescent Measurements; Naphthyridines; Neurotoxins; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridines; Pyrrolidinones; Ribonuclease, Pancreatic; Ribonucleases; Rolipram; Theophylline | 1995 |
Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Female; Gastric Fundus; In Vitro Techniques; Isoenzymes; Male; Muscle Relaxation; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrrolidinones; Rolipram; Vasoactive Intestinal Peptide | 1995 |
Effect of different xanthines and phosphodiesterase inhibitors on c-fos expression in rat striatum.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Administration Schedule; In Situ Hybridization; Male; Neostriatum; Nicotinic Acids; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins c-fos; Purinones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Xanthines | 1995 |
Multifactorial regulation of pituitary adenylate cyclase-activating polypeptide (PACAP)-induced production of cyclic AMP in ATT-20 corticotrophs: major involvement of Rolipram-sensitive and insensitive phosphodiesterases.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Alkaloids; Animals; Cell Line; Corticotropin-Releasing Hormone; Cyclic AMP; Enzyme Inhibitors; Kinetics; Male; Neuropeptides; Phosphodiesterase Inhibitors; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland, Anterior; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Staurosporine | 1995 |
Initial biochemical and functional characterization of cyclic nucleotide phosphodiesterase isozymes in canine colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Colforsin; Colon; Cyclic AMP; Cyclic GMP; Dogs; Isoenzymes; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rolipram | 1993 |
Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Dogs; Humans; Isoenzymes; Phosphodiesterase Inhibitors; Purinergic Antagonists; Pyrrolidinones; Rats; Receptors, Purinergic; Rolipram; Theophylline; Xanthines | 1993 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity | 1993 |
Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acid Sequence; Animals; Brain; Cell Line; Cell Membrane; Chlorocebus aethiops; Enzyme Stability; Kidney; Kinetics; Methionine; Phosphodiesterase Inhibitors; Protein Engineering; Pyrrolidinones; Rats; Recombinant Proteins; RNA, Messenger; Rolipram; Sequence Deletion; Thermodynamics; Transfection | 1993 |
Comparison of the effect of isobutylmethylxanthine and phosphodiesterase-selective inhibitors on cAMP levels in SH-SY5Y neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenylyl Cyclase Inhibitors; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Neuroblastoma; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Tumor Cells, Cultured | 1993 |
Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Astrocytoma; Bradykinin; Brain Neoplasms; Calcimycin; Calcium; Calmodulin; Colforsin; Cyclic AMP; Dopamine; Egtazic Acid; Humans; Hydroquinones; Inositol 1,4,5-Trisphosphate; Neoplasm Proteins; Pyrrolidinones; Rolipram; Signal Transduction; Tumor Cells, Cultured | 1993 |
Existence of rolipram-sensitive phosphodiesterase in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Diphosphate; Adenylyl Cyclases; Animals; Bone Marrow Cells; Calcimycin; Calcium Channels; Colforsin; Cyclic AMP; Electrophysiology; Female; In Vitro Techniques; Inosine Triphosphate; Isoquinolines; Male; Megakaryocytes; Nystatin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Rolipram | 1993 |
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Thiophenes | 1995 |
Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Amrinone; Animals; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; Liver; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram | 1996 |
cAMP decreases steady-state levels of delta-opioid receptor mRNA in NG108-15 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dinoprostone; Neuroblastoma; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Opioid, delta; RNA, Messenger; Rolipram | 1997 |
Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bucladesine; Cell Survival; Cyclic AMP; Dose-Response Relationship, Drug; fas Receptor; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Humans; Interleukin-5; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Proto-Oncogene Proteins c-bcl-2; Pyrrolidinones; Rolipram; Theophylline | 1997 |
Activity of cyclic AMP phosphodiesterases and adenylyl cyclase in peripheral nerve after crush and permanent transection injuries.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Gene Expression Regulation, Enzymologic; Male; Myelin Sheath; Nerve Crush; Nerve Regeneration; Phosphoric Diester Hydrolases; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Rolipram; S100 Proteins; Sciatic Nerve; Time Factors; Transcription, Genetic; Xanthines | 1998 |
Stimulation of renin secretion by nitric oxide is mediated by phosphodiesterase 3.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bumetanide; Cyclic Nucleotide Phosphodiesterases, Type 3; In Vitro Techniques; Isoproterenol; Kidney; Kinetics; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Renin; Rolipram | 1998 |
Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Contraceptive Agents, Female; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Estrus; Female; Fertilization; Heart Rate; Hypoxanthine; Isoenzymes; Meiosis; Menotropins; Mice; Mice, Inbred C57BL; Milrinone; Oogenesis; Ovarian Follicle; Ovulation; Ovulation Induction; Phosphodiesterase Inhibitors; Pregnancy; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Second Messenger Systems; Substrate Specificity; Thiophenes | 1998 |
Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Apoptosis; Cyclic AMP; Cyclic GMP; Female; HL-60 Cells; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram | 1998 |
Phosphodiesterase expression in human epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Cell Line; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 1; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Lung; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Thiophenes | 1998 |
Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antibodies; Antigens, Surface; Breast Neoplasms; Chemotaxis; Colforsin; Culture Media, Conditioned; Cyclic AMP; Female; Fibroblasts; Humans; Integrin alpha6beta4; Integrins; Kinetics; Lysophospholipids; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Signal Transduction; Tumor Cells, Cultured | 1998 |
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines | 1999 |
Effects of XT-44, a phosphodiesterase 4 inhibitor, in osteoblastgenesis and osteoclastgenesis in culture and its therapeutic effects in rat osteopenia models.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Bone Marrow Cells; Cyclic Nucleotide Phosphodiesterases, Type 4; Denervation; Dose-Response Relationship, Drug; Female; Femur; Giant Cells; Male; Mice; Osteoblasts; Osteoclasts; Osteogenesis; Ovariectomy; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Sciatic Nerve; Xanthines | 1999 |
Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Nucleus; Chromatography, High Pressure Liquid; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Ventricles; Intracellular Membranes; Isoenzymes; Myocardium; Pyrazines; Rolipram; Sheep | 1999 |
A cyclic nucleotide PDE5 inhibitor corrects defective mucin secretion in submandibular cells containing antibody directed against the cystic fibrosis transmembrane conductance regulator protein.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antibodies; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Isoproterenol; Mucins; Purinones; Pyridazines; Pyridines; Rats; Rolipram; Submandibular Gland | 1999 |
Differential regulation of nitric oxide production by increase of intracellular cAMP in murine primary fibroblasts and L929 fibrosarcoma cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Catalysis; Cells, Cultured; Cyclic AMP; Fibroblasts; Fibrosarcoma; Interferon-gamma; Intracellular Fluid; Mice; Mice, Inbred CBA; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphodiesterase Inhibitors; Rolipram; Tumor Cells, Cultured | 2000 |
Guanosine 3',5'-cyclic monophosphate mediated inhibition of cell death induced by nerve growth factor withdrawal and beta-amyloid: protective effects of propentofylline.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amyloid beta-Peptides; Animals; Apoptosis; Caspase 3; Caspases; Cyclic GMP; Dose-Response Relationship, Drug; Nerve Growth Factor; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; PC12 Cells; Penicillamine; Peptide Fragments; Phosphodiesterase Inhibitors; Rats; Rolipram; Xanthines | 2000 |
The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antigens, Dermatophagoides; Benzamides; Bronchi; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glycoproteins; Histamine; Humans; In Vitro Techniques; Leukotriene C4; Lung Neoplasms; Muscle Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridines; Rolipram; Theophylline | 2000 |
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diazepam; DNA, Complementary; Humans; Immunoblotting; Mice; Milrinone; Molecular Sequence Data; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rolipram; Sequence Homology, Amino Acid | 2001 |
Role of cyclic nucleotide phosphodiesterase isoenzymes in contractile responses of denuded rat aorta related to various Ca2+ sources.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Aorta; Calcium; Isoenzymes; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Wistar; Rolipram; Vasoconstriction | 2001 |
cAMP-elevating agents suppress dendritic cell function.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antigen Presentation; Cells, Cultured; Cyclic AMP; Dendritic Cells; Interleukin-10; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Rolipram; Tumor Necrosis Factor-alpha | 2001 |
Functional plasticity of cyclic AMP hydrolysis in rat adenohypophysial corticotroph cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Arginine Vasopressin; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Hydrolysis; Isoenzymes; Male; Mice; Models, Biological; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pituitary Gland, Anterior; Rats; Rats, Wistar; RNA, Messenger; Rolipram | 2002 |
Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Benzophenanthridines; Ciliary Body; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; In Vitro Techniques; Iris; Naltrexone; Narcotic Antagonists; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Protein Kinase C; Pyrrolidines; Rabbits; Receptors, Opioid, kappa; Rolipram | 2002 |
Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Antineoplastic Agents, Phytogenic; Arachidonic Acids; Breast Neoplasms; Cell Division; Cyclic AMP; Cyclic GMP; Dactinomycin; Enzyme Activation; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; Receptors, Estrogen; Resveratrol; Rolipram; Stilbenes; Tamoxifen; Tumor Cells, Cultured | 2003 |
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alanine; Amino Acid Sequence; Animals; Cloning, Molecular; Colforsin; COS Cells; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Glutathione Transferase; Humans; Immunoblotting; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Mutation; Open Reading Frames; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proteins; Rats; Recombinant Fusion Proteins; Rolipram; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Time Factors; Two-Hybrid System Techniques | 2003 |
Histamine up-regulates phosphodiesterase IV activity in U-937 cells through H2 receptor stimulation and cAMP increase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diphenhydramine; Guanidines; Histamine; Humans; Kinetics; Purinones; Pyridazines; Ranitidine; Receptors, Histamine H2; Rolipram; U937 Cells | 2003 |
Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Androstadienes; Animals; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Kinetics; Melanocyte-Stimulating Hormones; Melanophores; Melanosomes; Melatonin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Norepinephrine; Papaverine; Perciformes; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Rolipram; Signal Transduction; Wortmannin; Xenopus laevis | 2003 |
Antidiuretic hormone resistance in the neonatal cortical collecting tubule is mediated in part by elevated phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Age Factors; Animals; Animals, Newborn; Cyclic AMP; Kidney Concentrating Ability; Kidney Tubules, Collecting; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rabbits; Rolipram; Vasopressins | 2004 |
PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Actins; Animals; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Line; Cell Movement; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Embryo, Mammalian; Enzyme Activation; Fibroblasts; Integrins; Intracellular Signaling Peptides and Proteins; Laminin; Myosin-Light-Chain Kinase; Neuropeptides; Protein Serine-Threonine Kinases; Pseudopodia; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Rolipram | 2004 |
Altered activities of cyclic nucleotide phosphodiesterases and soluble guanylyl cyclase in cultured RFL-6 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Culture Techniques; Cell Line; Colforsin; Cyclic AMP; Fibroblasts; Gene Expression; Guanylate Cyclase; Lung; Nitric Oxide; Peptides, Cyclic; Phosphoric Diester Hydrolases; Rats; Receptors, Cell Surface; Rolipram; Solubility | 2004 |
Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Anti-Ulcer Agents; Bucladesine; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Gastric Mucosa; Humans; Isoenzymes; Isoquinolines; Neutrophils; Rolipram; Sulfonamides; Superoxides; Triazines | 2004 |
Crystallization of cyclic nucleotide phosphodiesterases.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Crystallography, X-Ray; Humans; Rolipram | 2005 |
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Dipyridamole; Female; Guanylate Cyclase; Histamine; Humans; In Vitro Techniques; Isoenzymes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthyridines; Nitroprusside; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Serotonin; Umbilical Arteries; Vasodilator Agents | 2008 |
Inhibition of protein kinase A improves effector function of monocytes from HIV-infected patients.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dinoprostone; Female; HIV; HIV Infections; Humans; Lipopolysaccharides; Male; Middle Aged; Monocytes; Phosphodiesterase Inhibitors; Rolipram; Tumor Necrosis Factor-alpha | 2008 |
PDE type-4 inhibition increases L-type Ca(2+) currents, action potential firing, and quantal size of exocytosis in mouse chromaffin cells.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Calcium Channels, L-Type; Chromaffin Cells; Cyclic Nucleotide Phosphodiesterases, Type 4; Ethanolamines; Exocytosis; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rolipram; Secretory Vesicles; Up-Regulation | 2009 |
Cyclic-AMP-dependent proliferation of a human osteoblast cell line (HOS cells) induced by hydroxyapatite: effect of exogenous nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Arginase; Cell Communication; Cell Differentiation; Cell Line; Colforsin; Colorimetry; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dichlororibofuranosylbenzimidazole; Durapatite; Guanylate Cyclase; Humans; Nitric Oxide; Nitric Oxide Donors; Osteoblasts; Penicillamine; Phosphodiesterase Inhibitors; Rolipram; S-Nitroso-N-Acetylpenicillamine | 2008 |
mc1r Pathway regulation of zebrafish melanosome dispersion.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Gene Expression Regulation, Developmental; Gene Silencing; Melanins; Melanocytes; Melanosomes; Receptor, Melanocortin, Type 2; Rolipram; Zebrafish | 2008 |
Acute hypoxia modifies cAMP levels induced by inhibitors of phosphodiesterase-4 in rat carotid bodies, carotid arteries and superior cervical ganglia.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Carotid Arteries; Carotid Body; Cell Hypoxia; Cyclic AMP; Female; In Vitro Techniques; Male; Oxygen; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Rolipram; Superior Cervical Ganglion | 2010 |
Prostanoid TP receptor-mediated impairment of cyclic AMP-dependent vasorelaxation is reversed by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Endothelium; Male; Phosphodiesterase Inhibitors; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Rolipram; Vasodilation | 2010 |
Phosphodiesterase isozymes involved in regulating acid secretion in the isolated mouse stomach.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine Agonists; Histamine Antagonists; Histamine Release; In Vitro Techniques; Isoenzymes; Male; Mice; Organ Specificity; Perfusion; Phosphodiesterase Inhibitors; Pituitary Adenylate Cyclase-Activating Polypeptide; Rolipram; Stomach; Time Factors | 2009 |
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glioblastoma; Guanine Nucleotide Exchange Factors; Humans; Isoquinolines; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Rolipram; Shelterin Complex; Signal Transduction; Sulfonamides; Telomere-Binding Proteins; Theophylline | 2012 |
Persistent cAMP signaling by TSH receptors revealed by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Biosensing Techniques; Cell Line, Tumor; Cyclic AMP; HEK293 Cells; Humans; Immunoassay; Luminescence; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Receptors, Thyrotropin; Rolipram; Signal Transduction; Thyroid Gland; Thyrotropin; Time Factors | 2013 |
NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aquaporin 2; Arginine Vasopressin; Blotting, Western; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Kidney Tubules, Collecting; Mice; NADPH Oxidase 4; NADPH Oxidases; Quinolones; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Rolipram; Signal Transduction | 2014 |
Atrazine suppresses FSH-induced steroidogenesis and LH-dependent expression of ovulatory genes through PDE-cAMP signaling pathway in human cumulus granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Atrazine; Cell Survival; Colforsin; Cumulus Cells; Cyclic AMP; Estradiol; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Humans; Luteinizing Hormone; Ovulation; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Progesterone; RNA, Messenger; Rolipram; Signal Transduction; Steroids | 2018 |
cAMP signaling primes lung endothelial cells to activate caspase-1 during
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Alprostadil; Animals; Caspase 1; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic GMP; Dinoprostone; Endothelial Cells; Gene Expression Regulation; Host-Pathogen Interactions; Inflammasomes; Interleukin-1beta; Lung; Primary Cell Culture; Pseudomonas aeruginosa; Rats; Rolipram; Signal Transduction; Single-Cell Analysis | 2020 |