1-methyl-3-isobutylxanthine has been researched along with roflumilast in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hughes, RA; Manallack, DT; Thompson, PE | 1 |
| de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R | 1 |
| Allart-Simon, I; Audonnet, S; Bisi, N; Gérard, S; Hénon, E; Laronze-Cochard, M; Moniot, A; Ponce-Vargas, M; Sapi, J; Velard, F | 1 |
| Chou, CL; Knepper, MA; Umejiego, EN; Wang, Y | 1 |
1 review(s) available for 1-methyl-3-isobutylxanthine and roflumilast
| Article | Year |
|---|---|
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines | 2005 |
3 other study(ies) available for 1-methyl-3-isobutylxanthine and roflumilast
| Article | Year |
|---|---|
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship | 2016 |
Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors.
Topics: | 2021 |
Roflumilast and aquaporin-2 regulation in rat renal inner medullary collecting duct.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyridines; Animals; Aquaporin 2; Benzamides; Capillary Permeability; Cyclopropanes; Dose-Response Relationship, Drug; Kidney Medulla; Kidney Tubules, Collecting; Male; Phosphodiesterase 4 Inhibitors; Phosphorylation; Protein Transport; Rats; Rats, Sprague-Dawley; Vasopressins; Water | 2017 |