1-methyl-3-isobutylxanthine has been researched along with pentoxifylline in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 13 (52.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Chen, G; Ke, H; Kunz, S; Martinelli, S; Robinson, H; Seebeck, T; Wan, Y; Wang, H | 1 |
| de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R | 1 |
| Bucki, A; Chłoń-Rzepa, G; Gawalska, A; Jankowska, A; Kołaczkowski, M; Pawłowski, M; Pociecha, K; Ślusarczyk, M; Świerczek, A; Wyska, E | 1 |
| de Prost, D; Hakim, J; Ollivier, V | 2 |
| Bang, YJ; Danielpour, D; Kim, KY; Kim, SJ; Myers, CE; O'Reilly, MA; Trepel, JB | 1 |
| Cohen, HJ; Currie, MS; McCachren, SS; Rao, KM | 1 |
| Emeis, JJ; Tranquille, N | 1 |
| Kunkel, SL; Larrick, J; Lynch, JP; Remick, DG; Spengler, RN; Strieter, RM; Ward, PA | 1 |
| Herman, G; Mauduit, P; Rossignol, B | 1 |
| Bruynzeel, I; Stoof, TJ; van der Raaij, LM; Willemze, R | 1 |
| Deguine, V; Dosne, AM; Greenberg, SM; Kerbiriou-Nabias, D; Lecoq, D; Meyer, D | 1 |
| Babin-Chevaye, C; Franzini, E; Hakim, J; Pasquier, C; Sellak, H | 1 |
| Babin-Chevaye, C; Franzini, E; Hakim, J; Marquetty, C; Pasquier, C; Sellak, H | 1 |
| de Koster, BM; Elferink, JG; Huizinga, TW | 1 |
| Buratti, T; Dunzendorfer, S; Herold, M; Kähler, CM; Reinisch, N; Schratzberger, P; Tilg, H; Wiedermann, CJ | 1 |
| Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M | 1 |
| Daly, JW; Shi, D | 1 |
| Edvinsson, L; Jansen-Olesen, I; Khurana, TS; Kruuse, C; Olesen, J; Rybalkin, SD | 1 |
| Hareng, L; Hartung, T; Meergans, T; Volk, HD; von Aulock, S | 1 |
| Anderson, CM; Thwaites, DT | 1 |
| Bulaeva, SV; Chuchkanov, FA; Maimistova, AA; Muravyov, AV; Yakusevich, VV; Zaitsev, LG | 1 |
| Baviera, AM; Goncalves, DA; Graca, FA; Kettelhut, IC; Lira, EC; Lönnroth, P; Migliorini, RH; Navegantes, LC; Strindberg, L; Zanon, NM | 1 |
| Bulaeva, SV; Miloradov, MJ; Muravyov, AV; Tikhomirova, IA; Uzikova, EV; Zamishlayev, AV | 1 |
1 trial(s) available for 1-methyl-3-isobutylxanthine and pentoxifylline
| Article | Year |
|---|---|
Macro- and microrheological parameters of blood in patients with cerebral and peripheral atherosclerosis: the molecular change mechanisms after pentoxifylline treatment.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Anemia; Blood Transfusion; Erythrocytes; Erythropoietin; Female; Hemorheology; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Organoplatinum Compounds; Pentoxifylline; Peripheral Arterial Disease; Phosphodiesterase Inhibitors; Prospective Studies; Recombinant Proteins; Rolipram; Vinca Alkaloids; Young Adult | 2011 |
24 other study(ies) available for 1-methyl-3-isobutylxanthine and pentoxifylline
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Design; Kinetics; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sulfonamides; Surface Properties; Trypanosoma cruzi | 2012 |
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship | 2016 |
Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanes; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 7; Dose-Response Relationship, Drug; Drug Design; Endotoxemia; Humans; Hydrazines; Lipopolysaccharides; Male; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Wistar; Structure-Activity Relationship | 2018 |
[Inhibition by pentoxifylline of procoagulant activity produced by endotoxin-active monocytes].
Topics: 1-Methyl-3-isobutylxanthine; Blood Coagulation; Bucladesine; Cyclic AMP; Dose-Response Relationship, Drug; Endotoxins; Humans; In Vitro Techniques; Monocytes; Pentoxifylline; Thromboplastin | 1992 |
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.
Topics: 1-Methyl-3-isobutylxanthine; Aprotinin; Blotting, Northern; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; DNA Replication; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Leupeptins; Male; Pentoxifylline; Phenylmethylsulfonyl Fluoride; Prostatic Neoplasms; RNA, Neoplasm; Theophylline; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Pentoxifylline inhibition of procoagulant activity generated by activated mononuclear phagocytes.
Topics: 1-Methyl-3-isobutylxanthine; Blood Coagulation Factors; Bucladesine; Cyclic AMP; Humans; Lipopolysaccharides; Monocytes; Pentoxifylline; Tumor Cells, Cultured | 1990 |
Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes.
Topics: 1-Methyl-3-isobutylxanthine; Aphidicolin; Calmodulin; Cells, Cultured; Cyclic AMP; Diterpenes; Histocompatibility Antigens Class I; Humans; Interleukin-2; Lymphocyte Activation; Lymphocytes; Pentoxifylline; Receptors, Interleukin-2; Receptors, Transferrin; RNA, Messenger | 1991 |
The effect of pentoxifylline (Trental) and two analogues, BL 194 and HWA 448, on the release of plasminogen activators and von Willebrand factor in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Endotoxins; Enzyme-Linked Immunosorbent Assay; Fibrinolysis; Hindlimb; In Vitro Techniques; Male; Pentoxifylline; Rats; Rats, Inbred Strains; Regional Blood Flow; Tissue Plasminogen Activator; von Willebrand Factor | 1991 |
Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Assay; Bucladesine; Cyclic AMP; Dinoprostone; Lipopolysaccharides; Mice; Pentoxifylline; Theobromine; Theophylline; Tumor Necrosis Factor-alpha | 1988 |
A tentative explanation of the stimulatory effect of methylxanthines (pentoxifylline and isobutylmethylxanthine) on the secretory process in rat extraorbital lacrimal gland.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carbachol; Dose-Response Relationship, Drug; Lacrimal Apparatus; Male; Norepinephrine; Pentoxifylline; Proteins; Rats; Rats, Inbred Strains; Sympathomimetics; Theobromine; Theophylline; Xanthines | 1981 |
Pentoxifylline inhibits T-cell adherence to keratinocytes.
Topics: 1-Methyl-3-isobutylxanthine; Cell Adhesion; Cyclic AMP; Enzyme-Linked Immunosorbent Assay; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Keratinocytes; Male; Organ Culture Techniques; Pentoxifylline; T-Lymphocytes; Tumor Necrosis Factor-alpha | 1995 |
Cyclic adenosine monophosphate-dependent mechanisms induce von Willebrand factor expression in the Dami megakaryoblastic cell line.
Topics: 1-Methyl-3-isobutylxanthine; Aneuploidy; Bucladesine; Colforsin; Cyclic AMP; Fluorescent Antibody Technique; Gene Expression Regulation, Leukemic; Humans; L-Lactate Dehydrogenase; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Neoplasm Proteins; Pentoxifylline; Platelet Membrane Glycoproteins; Tumor Cells, Cultured; von Willebrand Factor | 1995 |
Effects of pentoxifylline on the adherence of polymorphonuclear neutrophils to oxidant-stimulated human endothelial cells: involvement of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Cell Adhesion; Cells, Cultured; Cyclic AMP; Endothelium, Vascular; Humans; Isoproterenol; Neutrophils; Oxidants; Pentoxifylline; Phosphodiesterase Inhibitors; Reactive Oxygen Species | 1995 |
Inhibition of human neutrophil binding to hydrogen peroxide-treated endothelial cells by cAMP and hydroxyl radical scavengers.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Bucladesine; Cell Adhesion; Cells, Cultured; Cyclic AMP; Deferoxamine; Endothelium, Vascular; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Hydroxyl Radical; Hypoxanthine; Isoproterenol; Neutrophils; Pentoxifylline; Tetradecanoylphorbol Acetate; Thrombin; Transferrin; Umbilical Veins; Xanthine Oxidase | 1996 |
The effect of pentoxifylline on human neutrophil migration: a possible role for cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Cell Movement; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentoxifylline | 1997 |
Mediator-dependent effects of pentoxifylline on endothelium for transmigration of neutrophils.
Topics: 1-Methyl-3-isobutylxanthine; Adjuvants, Immunologic; Bucladesine; Cell Adhesion; Cell Movement; Endothelium, Vascular; Granulocyte Colony-Stimulating Factor; Humans; Interleukin-1; Interleukin-8; Lipopolysaccharides; Neutrophils; Pentoxifylline; Phosphodiesterase Inhibitors; Theophylline; Tumor Necrosis Factor-alpha | 1999 |
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines | 1999 |
Chronic effects of xanthines on levels of central receptors in mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Chemistry; Caffeine; Calcium Channels; Central Nervous System Stimulants; Cerebral Cortex; Corpus Striatum; Drug Interactions; Gene Expression Regulation; Male; Mice; Nerve Tissue Proteins; Pentoxifylline; Radioligand Assay; Receptors, Cholinergic; Receptors, Drug; Receptors, GABA; Receptors, Purinergic P1; Receptors, Serotonin; Theobromine; Theophylline; Xanthines | 1999 |
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Milrinone; Nitroprusside; Oxadiazoles; Pentoxifylline; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Vasodilation; Vasodilator Agents | 2001 |
Cyclic AMP increases endogenous granulocyte colony-stimulating factor formation in monocytes and THP-1 macrophages despite attenuated TNF-alpha formation.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Bucladesine; Cell Line; Colforsin; Cyclic AMP; Dinoprostone; Female; Granulocyte Colony-Stimulating Factor; Humans; In Vitro Techniques; Lipopolysaccharides; Macrophages; Monocytes; Naphthyridines; Pentoxifylline; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Tumor Necrosis Factor-alpha; Up-Regulation | 2003 |
Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3).
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Transport Systems; Caco-2 Cells; Caffeine; Dipeptides; Humans; Hydrogen-Ion Concentration; Pentoxifylline; Peptide Transporter 1; Phosphodiesterase Inhibitors; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Symporters; Theophylline | 2007 |
Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Blood Viscosity; Caffeine; Calcimycin; Calcium; Egtazic Acid; Erythrocyte Aggregation; Hemorheology; Humans; Male; Nifedipine; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Verapamil; Vinca Alkaloids | 2007 |
Cyclic adenosine monophosphate-phosphodiesterase inhibitors reduce skeletal muscle protein catabolism in septic rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carotid Arteries; Cyclic AMP; Male; Muscle, Skeletal; Muscles; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Sepsis; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |