1-methyl-3-isobutylxanthine has been researched along with naloxone in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (42.86) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Karras, PJ; North, RA | 1 |
| Chesher, GB; Jackson, DM; Malor, R; Zaluzny, SG | 1 |
| Neal, BS; Sparber, SB | 1 |
| Messing, RB; Neal, BS; Sparber, SB | 1 |
| Shimada, Y; Yamada, K; Yoshida, S | 1 |
| Hansen, HA; Mulder, AH; Schoffelmeer, AN; Stoof, JC | 1 |
| Laurent, S; Marsh, JD; Smith, TW | 1 |
| DeLander, GE; Hopkins, CJ | 1 |
| Kleven, MS; Sparber, SB | 1 |
| Collier, HO; Cuthbert, NJ; Francis, DL | 1 |
| Galloway, MP; Roth, RH | 1 |
| Grant, SJ; Redmond, DE | 1 |
| Bilsky, EJ; Porreca, F; Sadée, W; Wang, Z | 1 |
| Gelfand, RA; Jadus, MR; Parker, LN; Wepsic, HT | 1 |
| Gabrilovac, J | 1 |
| Avidor-Reiss, T; Bayewitch, M; Levy, R; Matus-Leibovitch, N; Nevo, I; Vogel, Z | 1 |
| Bilsky, EJ; Porreca, F; Sadée, W; Wang, D; Wang, Z | 1 |
| Baldelli, P; Carabelli, V; Carbone, E; Hernández-Guijo, JM | 1 |
| Baumgart, MI; Schrott, LM; Sparber, SB; Zhang, X | 1 |
| Ahn, DS; Chae, JE; Chang, CH; Cho, YL; Kim, MH; Park, WK | 1 |
| Cvijic, ME; Kang, L; Kong, Y; Shei, GJ; Wang, Y | 1 |
21 other study(ies) available for 1-methyl-3-isobutylxanthine and naloxone
| Article | Year |
|---|---|
Inhibition of neuronal firing by opiates: evidence against the involvement of cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Bucladesine; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Naloxone; Narcotics; Neurons; Prostaglandins E; Time Factors | 1979 |
The attenuation of delta 9-tetrahydrocannabinol and morphine of the quasi-morphine withdrawal syndrome in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Chlordiazepoxide; Dronabinol; Haloperidol; Humans; Male; Morphine; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome | 1979 |
The serotonin2 antagonist ritanserin blocks quasi-morphine withdrawal at a time when mianserin is no longer effective.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Conditioning, Operant; Male; Mianserin; Morphine Dependence; Naloxone; Piperidines; Rats; Reinforcement Schedule; Ritanserin; Serotonin Antagonists; Substance Withdrawal Syndrome | 1990 |
Long-term effects of neonatal exposure to isobutylmethylxanthine. II. Attenuation of acute morphine withdrawal in mature rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Body Temperature; Conditioning, Operant; Dose-Response Relationship, Drug; Mianserin; Morphine; Naloxone; Rats; Receptors, Opioid; Reinforcement Schedule; Substance Withdrawal Syndrome | 1991 |
Atrial natriuretic polypeptide secretion via selective activation of kappa-opioid receptor: role of dynorphin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Benzomorphans; Cells, Cultured; Diuretics; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Heart; Heart Atria; Kinetics; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1991 |
Inhibition of dopamine-stimulated cyclic AMP efflux from rat neostriatal slices by activation of mu- and delta-opioid receptors: a permissive role for D-2 dopamine receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Corpus Striatum; Cyclic AMP; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Enkephalins increase cyclic adenosine monophosphate content, calcium uptake, and contractile state in cultured chick embryo heart cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Chick Embryo; Cyclic AMP; Enkephalin, Methionine; Enkephalins; GTP-Binding Proteins; Heart; Myocardial Contraction; Myocardium; Naloxone | 1986 |
Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Analgesia; Animals; Caffeine; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Nociceptors; Spinal Cord; Theophylline; Xanthines | 1986 |
Morphine blocks and naloxone enhances suppression of operant behavior by low doses of 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Body Temperature; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Theophylline | 1989 |
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Humans; Hypoxanthines; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Pyrimidines; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Triazoles; Xanthines | 1981 |
Clonidine prevents methylxanthine stimulation of norepinephrine metabolism in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Brain; Cerebellum; Clonidine; Diazepam; Hippocampus; Kinetics; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Clonidine suppresses methylxanthine induced quasi-morphine withdrawal syndrome.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Clonidine; Humans; Male; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome; Theophylline | 1982 |
Constitutive mu opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cerebral Ventricles; Cyclic AMP; Drug Tolerance; Homeostasis; Humans; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Neuroblastoma; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome; Tumor Cells, Cultured; Up-Regulation | 1994 |
Prostaglandin E2 induces up-regulation of murine macrophage beta-endorphin receptors.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; beta-Endorphin; Binding, Competitive; Bone Marrow Cells; Cells, Cultured; Dinoprostone; Macrophages; Mice; Mice, Inbred DBA; Molecular Sequence Data; Naloxone; Peptide Fragments; Protein Binding; Receptors, Opioid; Up-Regulation | 1995 |
Leu-enkephalin modulates the migration inhibition of mouse splenocytes induced by cAMP-elevating agents.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Migration Inhibition; Cell Movement; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; In Vitro Techniques; Mice; Mice, Inbred CBA; Naloxone; Spleen; Theophylline | 1993 |
Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics; Analgesics, Opioid; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Morphine; Naloxone; Pertussis Toxin; Phosphodiesterase Inhibitors; Rats; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1995 |
3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Cyclic AMP; Drug Tolerance; Mice; Morphine Dependence; Naloxone; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Phosphorylation; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Time Factors | 1999 |
Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Autocrine Communication; Calcium; Calcium Channels, L-Type; Cattle; Cells, Cultured; Chromaffin Cells; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; GABA Antagonists; Isoquinolines; Kinetics; Naloxone; Narcotic Antagonists; Patch-Clamp Techniques; Picrotoxin; Protein Kinase Inhibitors; Sulfonamides; Suramin | 2001 |
Prenatal opiate withdrawal activates the chick embryo hypothalamic pituitary-adrenal axis and dilates vitelline blood vessels via serotonin(2) receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chick Embryo; Corticosterone; Disease Models, Animal; Hypothalamo-Hypophyseal System; Methadyl Acetate; Morphogenesis; Naloxone; Narcotics; Pituitary-Adrenal System; Receptors, Serotonin; Ritanserin; Substance Withdrawal Syndrome | 2002 |
Phosphodiesterase inhibition by naloxone augments the inotropic actions of beta-adrenergic stimulation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cardiotonic Agents; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Myocardium; Naloxone; Narcotic Antagonists; Papillary Muscles; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors | 2009 |
Development of a cyclic adenosine monophosphate assay for Gi-coupled G protein-coupled receptors by utilizing the endogenous calcitonin activity in Chinese hamster ovary cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Calcitonin; Cell Culture Techniques; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Female; Humans; Inhibitory Concentration 50; Ligands; Molecular Targeted Therapy; Naloxone; Narcotic Antagonists; Phosphodiesterase Inhibitors; Radioligand Assay; Rats; Receptors, Calcitonin; Receptors, G-Protein-Coupled; Receptors, Islet Amyloid Polypeptide; Receptors, Opioid, mu; Salmon | 2011 |