1-methyl-3-isobutylxanthine and glucagon-like peptide 1

1-methyl-3-isobutylxanthine has been researched along with glucagon-like peptide 1 in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (46.67)18.2507
2000's13 (43.33)29.6817
2010's2 (6.67)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Itoh, H; Komatsu, R; Kono, N; Matsumura, T; Matsuyama, T; Matsuzawa, Y; Namba, M; Oda, Y; Tanaka, M; Watanabe, N1
Arnold, R; Bächle, R; Fehmann, HC; Göke, B; Göke, R; Wagner, B1
Classen, M; Fürlinger, C; Janczewska, I; Schepp, W; Schmidtler, J; Schusdziarra, V; Weigert, N1
Abrahamsen, N; Nishimura, E1
Asa, SL; Brubaker, PL; Drucker, DJ; Jin, T; Young, TA1
Hanafusa, T; Kuwajima, M; Matsumura, T; Matsuzawa, Y; Miki, H; Mineo, I; Miyagawa, J; Nakajima, H; Namba, M; Nishimura, T1
Laychock, SG1
Ahrén, B; Karlsson, S; Simonsson, E2
Boissard, C; Chastre, E; Marie, JC; Phan, HH; Rosselin, G1
Deeg, MA; Verchere, CB1
Ding, WG; Gromada, J1
Nakata, M; Tanaka, H; Yada, T; Yaekura, K1
Egan, JM; Montrose, MH; Montrose-Rafizadeh, C; Moyes, CD; Roth, J; Wang, Y; Yang, H1
Mamujee, SN; Sun, AM; Vacek, I; Wheeler, MB; Zhou, D1
Daniel, PB; Habener, JF; Hussain, MA1
Brubaker, PL; Dhanvantari, S; Izzo, A; Jansen, E1
Díaz-Miguel, M; González, N; Márquez, L; Valverde, I; Villanueva-Peñacarrillo, ML1
Aizawa, T; Hashizume, K; Komatsu, M; Sato, Y; Yamada, S; Yamauchi, K1
De Proft, R; Dejonghe, S; Gorus, F; Ling, Z; Pipeleers, D; Schuit, F; Winnock, F1
Civelek, VN; Corkey, BE; Cunningham, BA; Daley, JT; Deeney, JT; Dillon, JS; Richard, AM; Tornheim, K; Yaney, GC1
Aizawa, T; Hashizume, K; Kojima, I; Komatsu, M; Sato, Y; Yamada, S; Yamauchi, K1
Lee, JW; Romsos, DR; Swick, AG1
Buettger, CW; Carr, RD; Collins, HW; Doliba, NM; Li, C; Magnuson, MA; Matschinsky, FM; Najafi, H; Qin, W; Vatamaniuk, MZ; Zelent, D1
Collord, GJ; Gribble, FM; Habib, AM; Reimann, F; Simpson, AK; Ward, PS; Wong, KY1
Bara, H; Sambanis, A1
Harada, N; Hosaka, T; Kim Chung, le T; Nakaya, Y; Sakai, T; Sakaue, H; Yoshida, M1
Cornu, M; Joffraud, M; Kawamori, D; Kulkarni, RN; Modi, H; Thorens, B1
Chimerel, C; Gribble, FM; Murison, K; Reimann, F; Riccio, C1
Anini, Y; Bado, A; Benadda, S; Cavin, JB; Couvelard, A; Hourseau, M; Jarry, AC; Le Beyec, J; Le Gall, M; Ledoux, S; Léger, T; Marmuse, JP; Morlet, B; Msika, S; Pelletier, AL; Ribeiro-Parenti, L; Sannier, A; Willemetz, A1

Other Studies

30 other study(ies) available for 1-methyl-3-isobutylxanthine and glucagon-like peptide 1

ArticleYear
Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells.
    Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Clone Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptide Fragments; Peptides

1992
Priming effect of glucagon-like peptide-1 (7-36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas.
    Biochimica et biophysica acta, 1991, Feb-19, Volume: 1091, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Sincalide

1991
GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function.
    The American journal of physiology, 1991, Volume: 260, Issue:6 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Biological Transport; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; In Vitro Techniques; Inositol Phosphates; Kinetics; Parietal Cells, Gastric; Peptide Fragments; Peptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella

1991
Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids.
    Endocrinology, 1995, Volume: 136, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Ribonucleases; RNA, Messenger

1995
Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.
    Molecular endocrinology (Baltimore, Md.), 1994, Volume: 8, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Polyomavirus Transforming; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Intestinal Neoplasms; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Electron; Neoplasm Transplantation; Peptide Fragments; Proglucagon; Protein Precursors; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured

1994
Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes.
    Biochimica et biophysica acta, 1996, Jun-13, Volume: 1312, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Animals; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Glucose; Insulin; Male; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Rats

1996
Impaired cyclic AMP response to stimuli in glucose-desensitized rat pancreatic islets.
    Molecular and cellular endocrinology, 1995, Aug-30, Volume: 113, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Drug Tolerance; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley

1995
Glucagon-like peptide-1(7-36)amide and cytoplasmic calcium in insulin producing cells.
    Acta physiologica Scandinavica, 1996, Volume: 157, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cytoplasm; Fura-2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulinoma; Islets of Langerhans; Male; Neurotransmitter Agents; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Sincalide; Tumor Cells, Cultured

1996
Effect of PACAP, VIP, glucagon, and GLP1 on cAMP production and insulin release of HIT-T15 cells is passage dependent.
    Annals of the New York Academy of Sciences, 1996, Dec-26, Volume: 805

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Line, Transformed; Colforsin; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Swine; Vasoactive Intestinal Peptide

1996
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
    Endocrinology, 1997, Volume: 138, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Pancreatic Neoplasms; Peptide Fragments; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1997
Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucose-dependent insulinotropic polypeptide.
    Diabetes, 1997, Volume: 46, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Exocytosis; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Peptide Fragments; Phosphodiesterase Inhibitors; Tetradecanoylphorbol Acetate; Thionucleotides

1997
Cyclic AMP, a mediator of GLP-1, acts in concert with glucose and tolbutamide to increase cytosolic Ca2+ in pancreatic B-cells.
    Advances in experimental medicine and biology, 1997, Volume: 426

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islets of Langerhans; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide

1997
GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cell Line; Cloning, Molecular; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycogen; Glycolysis; Insulin; Kinetics; Muscle, Skeletal; Pancreas; Peptide Fragments; Protein Precursors; Rats; Receptors, Glucagon; Recombinant Proteins; Transfection; Venoms

1998
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
    Annals of transplantation, 1997, Volume: 2, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Capsules; Cell Division; Cell Separation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Insulinoma; Pancreas, Artificial; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Time Factors; Tumor Cells, Cultured

1997
The cyclic AMP-protein kinase A pathway restrains islet phospholipase A(2) activation.
    Biochemical and biophysical research communications, 2000, Mar-05, Volume: 269, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Carbachol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Melitten; Peptide Fragments; Phospholipases A; Protein Precursors; Rats; Rats, Sprague-Dawley; Signal Transduction; Sincalide; Vasoactive Intestinal Peptide

2000
Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells.
    Diabetes, 2000, Volume: 49, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding Sites; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Diabetes Mellitus; DNA; DNA-Binding Proteins; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Insulin; Islets of Langerhans; Male; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2000
Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells.
    Endocrinology, 2001, Volume: 142, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Aspartic Acid Endopeptidases; Cell Line; Colforsin; Gene Expression Regulation; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Kinetics; Luciferases; Mice; Peptide Fragments; Proglucagon; Proprotein Convertase 1; Proprotein Convertases; Protein Precursors; Rats; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection

2001
Effect of GLP-1 on lipid metabolism in human adipocytes.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2001, Volume: 33, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Cyclic AMP; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Lipid Metabolism; Lipids; Lipolysis; Male; Middle Aged; Peptide Fragments; Protein Precursors

2001
Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon.
    Diabetes, 2002, Volume: 51 Suppl 1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Colforsin; Cyclic AMP; Diazoxide; Glucagon; Glucagon-Like Peptide 1; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Phosphodiesterase Inhibitors; Potassium Channels; Protein Precursors; Rats; Rats, Wistar; Signal Transduction; Sodium Azide; Vasodilator Agents

2002
Correlation between GABA release from rat islet beta-cells and their metabolic state.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Calcium; Culture Media, Conditioned; Cycloheximide; Diazoxide; gamma-Aminobutyric Acid; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamate Decarboxylase; Glyburide; Islets of Langerhans; Male; Mannoheptulose; Oxidation-Reduction; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Verapamil

2002
Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets.
    The Biochemical journal, 2003, Jan-01, Volume: 369, Issue:Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Lipolysis; Male; Peptide Fragments; Phosphofructokinase-2; Protein Precursors; Rats; Rats, Sprague-Dawley; Rats, Wistar

2003
Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell.
    Endocrinology, 2002, Volume: 143, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Calcium; Cerulenin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Membrane Potentials; Peptide Fragments; Potassium; Protein Precursors; Rats; Rats, Wistar

2002
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
    Experimental biology and medicine (Maywood, N.J.), 2003, Volume: 228, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin

2003
Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 286, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; ATP-Binding Cassette Transporters; Blood Glucose; Calcium; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Intracellular Fluid; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Peptide Fragments; Phosphodiesterase Inhibitors; Potassium Channels, Inwardly Rectifying; Protein Precursors; Receptors, Drug; Second Messenger Systems; Signal Transduction; Sulfonylurea Receptors

2004
Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line.
    Diabetologia, 2007, Volume: 50, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Colforsin; Cyclic AMP; Enteroendocrine Cells; Glucagon-Like Peptide 1; Humans; Ion Channels; Membrane Potentials

2007
Insulin-secreting L-cells for the treatment of insulin-dependent diabetes.
    Biochemical and biophysical research communications, 2008, Jun-20, Volume: 371, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Diabetes Mellitus; Drug Resistance; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Neomycin; Proinsulin; Transfection

2008
Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression.
    Biochemical and biophysical research communications, 2009, Dec-18, Volume: 390, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipocytes; Adipokines; Adiponectin; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Inflammation; Insulin Resistance; Isoquinolines; Mice; Peptides; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Receptors, Glucagon; RNA, Messenger; Sulfonamides; Venoms

2009
Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.
    The Journal of biological chemistry, 2010, Apr-02, Volume: 285, Issue:14

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Fluorescent Antibody Technique; Glucagon-Like Peptide 1; Glucose; Insulin-Like Growth Factor II; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Biosynthesis; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic

2010
Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release.
    Endocrinology, 2017, 10-01, Volume: 158, Issue:10

    Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Colforsin; Enteroendocrine Cells; Glucagon-Like Peptide 1; Membrane Potentials; Mice; Nifedipine; omega-Conotoxin GVIA; Optogenetics; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rhodopsin; Sodium Channel Blockers; Tetrodotoxin; Vasodilator Agents

2017
Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells.
    Nature communications, 2021, 01-04, Volume: 12, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adult; Amino Acid Sequence; Animals; Bariatric Surgery; Diet, High-Fat; Female; Gastric Mucosa; Glucagon-Like Peptide 1; Glucose; Humans; Male; Middle Aged; Obesity; Phenotype; Rats, Wistar

2021