1-methyl-3-isobutylxanthine has been researched along with cyclic gmp in 582 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 171 (29.38) | 18.7374 |
| 1990's | 281 (48.28) | 18.2507 |
| 2000's | 110 (18.90) | 29.6817 |
| 2010's | 18 (3.09) | 24.3611 |
| 2020's | 2 (0.34) | 2.80 |
| Authors | Studies |
|---|---|
| Birnbaumer, L; Entman, ML; Garber, AJ | 1 |
| Bennett, T; Strange, PG | 1 |
| Coquil, JF; Hamet, P | 1 |
| Bloom, SR; Iversen, LL; Quik, M | 1 |
| Hofbauer, KG; Konrads, A; Schwarz, K; Werner, U | 1 |
| Handler, JS; Sahib, MK; Schwartz, JH | 1 |
| Brackett, NL; Helfman, DM; Kuo, JF; Shoji, M | 1 |
| Fawcett, CP; McCann, SM; Naor, Z; Snyder, G | 1 |
| Andersson, RG; Brundin, A; Lindgren, BR | 1 |
| Gagerman, E; Hellman, B; Täljedal, IB | 1 |
| Kraicer, J; Sheppard, MS; Spence, JW | 1 |
| Brown, BS; Krzanowski, JJ; Polson, JB | 1 |
| Losier, AJ; YoungLai, EV | 1 |
| Garbers, DL; Kopf, GS; Tubb, DJ | 1 |
| Adachi, K; Halprin, KM; Iizuka, H; Levine, V | 1 |
| Donaldson, RM; Ebersole, ER; Kapadia, CR; Schafer, DE | 1 |
| Austen, KF; Goetzl, EJ; Pickett, WC | 1 |
| Pritchard, ET; Spearman, TN | 1 |
| Engels, J; Korth, M | 1 |
| Butcher, RW; Nemecek, GM | 1 |
| Böhme, E; Klatt, P; Mayer, B; Schmidt, K | 1 |
| Barsony, J; McKoy, W | 1 |
| Benzing, T; Busse, R; Hecker, M | 1 |
| Assender, JW; Hallett, MB; Newby, AC; Southgate, KM | 1 |
| Cernacek, P; Legault, L; Levy, M; Stewart, DJ | 1 |
| Khalifa-Zade, MCh; Kolesnikov, SS; Kosolapov, AV | 1 |
| Cramb, G; Gilkes, AF; Guild, SB; MacKay, KB | 1 |
| Mukhopadhyay, AK; Müller, D; Schumacher, H | 1 |
| Altiok, N; Fredholm, BB | 1 |
| Wei, JW; Wei, MM | 1 |
| Hildebrand, E; Schimz, A | 1 |
| Ashikaga, T; Kishi, Y; Numano, F | 1 |
| Gauthier, C; Le Bec, A; Lugnier, C; Soustre, H | 1 |
| Barsony, J; Kohidai, L; Marx, SJ; Roth, J | 1 |
| Giridhar, J; Isom, GE; Peoples, RW | 1 |
| Diamond, J; Stern, PH | 1 |
| Catravas, JD; Marczin, N; Ryan, US | 1 |
| Buchholz, RA; Pagani, ED; Silver, PJ | 1 |
| Zatz, M | 1 |
| Okada, D | 1 |
| Ache, BW; Michel, WC | 1 |
| Barber, R; Butcher, RW; Goka, TJ | 1 |
| Barnett, R; Blaufox, S; Nord, EP; Ortiz, PA; Ramsammy, L; Singer, S | 1 |
| Ertel, EA | 1 |
| Allan, BJ; Ensign, WY; Izutsu, KT; Ramsey, BW; Schubert, MM; Truelove, EL | 1 |
| Adolfs, MJ; Bonta, IL; De Jonge, HR; Houdijk, AP | 1 |
| Blayney, LM; Gapper, PW; Newby, AC | 1 |
| Jahr, CE; Nawy, S | 1 |
| Beasley, D | 1 |
| Garg, UC; Hassid, A | 2 |
| Corbin, JD; Francis, SH; Thomas, MK | 1 |
| Fukuda, A; Minami, T; Nabekura, J; Oomura, Y | 1 |
| Ney, P; Schröder, H; Schrör, K; Woditsch, I | 1 |
| Appel, RG | 1 |
| Fischmeister, R; Hartzell, HC | 2 |
| Hirsch, J | 1 |
| Cornwall, MC; Fein, A; MacNichol, EF | 1 |
| Beavo, J; Jacobson, KL; McPhee, C; Singh, JC; Watson, EL | 1 |
| Berson, EL; Miller, S; Sandberg, MA | 1 |
| Goy, MF | 1 |
| Meeley, MP; Regunathan, S; Reis, DJ | 1 |
| Myers, LM; Sumners, C | 1 |
| Schwarzschild, MA; Zigmond, RE | 1 |
| Moreno, S; Tomes, C | 1 |
| Flawn, P; Loten, EG | 1 |
| Fischmeister, R; Lohmann, SM; Méry, PF; Walter, U | 1 |
| Das, S; Garepapaghi, M; Palmer, LG | 1 |
| Ardaillou, R; Béa, ML; Bens, M; Dussaule, JC | 1 |
| Aronica, SM; Katzenellenbogen, BS | 1 |
| Frings, S; Lindemann, B | 1 |
| Wainwright, LK; Wainwright, SD | 2 |
| Blazquez, JL; Colin, JP; Folcòn, J; Ling, N; Thibault, C; Vaudry, H | 1 |
| Korbut, R; Radziszewski, W; Salvemini, D; Vane, J | 1 |
| Junquero, DC; Schini, VB; Scott-Burden, T; Vanhoutte, PM | 1 |
| Hamet, P; Kuchel, O; Matusak, O | 1 |
| Darrow, B; Firestein, S; Shepherd, GM | 1 |
| Hamet, P; Tremblay, J | 1 |
| Lachowicz, L; Turski, WA | 1 |
| Nunes, JP; Soares-da-Silva, P; Villanueva, MM | 1 |
| Ishizaki, Y; Ma, LJ; Morita, I; Murota, S | 1 |
| Mensah, LM; Murray, KJ; Worby, A | 1 |
| Anderson, RJ; Breckon, R; Colston, D | 1 |
| Jungermann, K; Runge, D | 1 |
| Nakatani, K; Tamura, T; Yau, KW | 1 |
| Firestein, S; Shepherd, GM; Zufall, F | 1 |
| Haneda, M; Horide, N; Kajiwara, N; Kikkawa, R; Koya, D; Maeda, S; Shigeta, Y; Togawa, M | 1 |
| Fujita, N; Hayashi, H; Okada, N; Shibanaka, Y | 1 |
| Braquet, P; Chabrier, PE; Demerlé-Pallardy, C; Lonchampt, MO | 1 |
| Gotow, T; Nishi, T | 3 |
| Beavo, JA; Stroop, SD | 1 |
| Cobbs, WH | 1 |
| Ervens, J; Seifert, R; Wenzel-Seifert, K | 1 |
| Anggard, E; Mollace, V; Salvemini, D; Vane, J | 1 |
| Fiscus, RR; Han, C; Wang, X | 1 |
| Dewey, D; Douglas, PB; Putnam, RW | 1 |
| Chiba, S; Horiuchi, A; Iwatsuki, K; Ren, LM | 1 |
| Adolfs, MJ; Bonta, IL; De Jonge, HR; Houdijk, AP; Van Leeuwen, PA | 1 |
| Brückner, R; Gramann, S; Nose, M; Schmitz, W; Scholz, H | 1 |
| Blazynski, C; Cohen, AI; Ferrendelli, JA | 1 |
| Craven, PA; DeRubertis, FR | 2 |
| Hofmann, KP; Kamps, KM; Reichert, J | 1 |
| Dohi, T; Kitayama, S; Morita, K; Tsujimoto, A | 1 |
| Alberts, P; Ogren, VR; Sellström, AI | 1 |
| Heim, HK; Ruoff, HJ | 1 |
| Hori, R; Imura, H; Inui, K; Kiso, Y; Matsukawa, Y; Morii, N; Nakao, K; Saito, H; Shimokura, M | 1 |
| Kraicer, J; Moor, BC; Sheppard, MS | 1 |
| Daemen, FJ; de Grip, WJ; Dratz, EA; Kamps, KM | 1 |
| Friedl, A; Hamprecht, B; Harmening, C | 1 |
| Furchgott, RF; Jothianandan, D; Martin, W; Villani, GM | 1 |
| Le Bec, A; Lugnier, C; Schoeffter, P; Stoclet, JC; Strouthou, E | 1 |
| Gemba, M; Mikuriya, N; Nakajima, M; Nakanishi, J | 1 |
| Morton, DB; Truman, JW | 1 |
| Kwon, HB; Schuetz, AW | 1 |
| Kendall, DA | 1 |
| Adachi, S; Nagahama, Y; Tan, JD | 1 |
| Aiyar, N; Crooke, ST; Gessner, G; Nambi, P; Whitman, M | 1 |
| O'Donnell, ME; Owen, NE | 1 |
| Fiscus, RR; Murad, F; Robles, BT; Waldman, SA | 1 |
| Cassity, N; Martinez, JR | 1 |
| Laychock, SG | 1 |
| Basci, A; Shah, SV; Wallin, JD | 1 |
| Brenner, BM; Seifter, JL; Silva, P; Zeidel, ML | 1 |
| Ignarro, LJ; Wood, KS | 1 |
| Manganiello, VC; Osborne, JC; Wada, H | 2 |
| Dage, RC; Hsieh, CP; Kariya, T; Ruberg, SJ | 1 |
| Segal, J | 1 |
| Narahashi, T; Tsunoo, A | 1 |
| Gemignani, A; Marchi, M; Paudice, P; Raiteri, M | 1 |
| Cline, WH; Nickols, GA | 1 |
| Butlen, D; Chabardès, D; Mistaoui, M; Montégut, M; Morel, F | 1 |
| Goldberg, ND; Graeff, RM; Walseth, TF | 1 |
| Lincoln, TM; Smith, JB | 1 |
| Duemler, BH; Keravis, TM; Kuttesch, NJ; Sullivan, TA; Wells, JN | 1 |
| Singh, JC; Watson, EL | 1 |
| Athias, P; Ettaiche, M; Variot, N | 1 |
| Groome, JR; Watson, WH | 2 |
| Fain, GL; Schröder, WH | 1 |
| Haynes, LW; Nakatani, K; Yau, KW | 1 |
| Berg, DK; Dionne, VE; Margiotta, JF | 1 |
| Brunswig, B; Budnik, LT; Mukhopadhyay, AK | 1 |
| Bryson, SE; Rodger, IW | 1 |
| Kreisberg, J; Kremer, S; Skorecki, K; Troyer, D | 1 |
| Berson, EL; Crane, WG; Pawlyk, BS; Sandberg, MA; Schmidt, SY | 1 |
| Orekhov, AN; Smirnov, VN; Tertov, VV | 1 |
| Berkowitz, AS; Preslock, JP; Wun, WS | 1 |
| Kirk, MD; Scheller, RH; Taussig, R | 1 |
| Eckstein, H | 1 |
| Hartzell, HC; Simmons, MA | 1 |
| Hurwitz, S; Pines, M | 2 |
| Böhm, M; Brückner, R; Neumann, J; Nose, M; Schmitz, W; Scholz, H | 1 |
| Butler, RD; Evans, RL; McCrohan, CR | 1 |
| Furuya, M; Hayashi, Y; Iwasa, F; Ohnuma, N | 1 |
| Alberts, P; Ogren, VR | 1 |
| Nakatani, K; Yau, KW | 1 |
| Degerman, E; Elks, M; Manganiello, V | 1 |
| Díez, J; Esparza, N | 1 |
| Laasberg, T; Neuman, T; Paves, H; Pihlak, A; Saarma, M | 1 |
| Anderson, RJ; Dillingham, MA | 1 |
| Iida, H; Page, E | 1 |
| Clancey, MA; Gerzer, R; Graber, SE; Wells, JN | 1 |
| Friedl, A; Hamprecht, B; Harmening, C; Schiller, M; Schmalz, F; Schuricht, B | 1 |
| Aghajanian, GK; Wang, YY | 1 |
| Marumo, F; Shiigai, T; Terada, Y; Tomita, K; Yoshiyama, N | 1 |
| Berry, L; Brigham, KL; Graber, S; Hussein, A; Meyrick, B | 1 |
| Berton, F; Brunelli, M; Garcia-Gil, M; Tongiorgi, E | 1 |
| Ichinose, M; McAdoo, DJ | 1 |
| Ishii, K; Murad, F | 1 |
| Hilf, G; Merz, WE | 2 |
| Koch, B; Lutz-Bucher, B | 1 |
| Arend, LJ; Gusovsky, F; Handler, JS; Rhim, JS; Spielman, WS | 1 |
| Benishin, CG; Pang, PK; Zeng, YY | 1 |
| Hodgkin, AL; Nunn, BJ | 1 |
| Ames, A; Barad, M | 1 |
| DiFrancesco, D; Tromba, C | 1 |
| Stieve, H | 1 |
| Kotecha, N; Neild, TO | 1 |
| Rodger, IW; Shahid, M | 1 |
| Brazdil, R; Diocee, BK; Jordan, R; Souness, JE | 1 |
| Houslay, MD; Lakey, T; Lavan, BE | 1 |
| Kamiya, J; Kawai, K; Kobari, T; Maruyama, M | 1 |
| Fong, J; Hirschowitz, BI; Inoue, M; Shah, G | 1 |
| Kane, KA; Morcillo-Sanchez, EJ; Parratt, JR; Rodger, IW; Shahid, M | 1 |
| Hirata, Y; Takada, S; Tomita, M; Yoshimi, H | 1 |
| Erneux, C; Miot, F; Van Haastert, PJ | 1 |
| Abboud, HE; Sedor, JR | 1 |
| Corbin, JD; Francis, SH; Lincoln, TM | 1 |
| Brown, BS; Krzanowski, JJ; Polson, JB; Wiggins, JR | 1 |
| Ausiello, DA; Karnovsky, MJ; Kreisberg, JI; Roy, C | 1 |
| Atkinson, JP; Fischbein, LC; Simchowitz, L; Spilberg, I | 1 |
| Gruetter, CA; Ignarro, LJ; Kadowitz, PJ; Napoli, SA | 1 |
| Andersson, RG; Börjesson, S; Nilsson, KB | 1 |
| Casnellie, JE; Greengard, P; Ives, HE; Jamieson, JD | 1 |
| Levitan, IB; Norman, J | 1 |
| Gualtieri, RT; Hechter, O; Janis, RA; Schlageter, N | 1 |
| Epstein, PM; Hersh, EM; Ross, CP; Strada, SJ; Thompson, WJ | 1 |
| Boutwell, RK; Perchellet, JP | 3 |
| Betteridge, A | 1 |
| Abboud, HE; Dousa, TP; Shah, SV | 1 |
| Schwartz, LM; Truman, JW | 1 |
| Oleshansky, MA | 1 |
| Bartfai, T; Danielsson, E; Nordström, O | 1 |
| Best, LC; Bone, EA; Holland, TK; Hunt, NH; Jones, PB | 1 |
| Bourke, JR; Carseldine, KL; Ferris, SH; Huxham, GJ; Manley, SW | 1 |
| George, WJ; White, LE | 1 |
| Mackenzie, CW | 1 |
| Bicknell, RJ; Schofield, JG | 1 |
| Frey, EA; McIsaac, RJ | 1 |
| Kramer, GL; Wells, JN | 1 |
| Fredholm, B; Sydbom, A; Uvnäs, B | 1 |
| Bochkin, LM; Ostrovskiĭ, MA; Zak, PP | 1 |
| Rochette-Egly, C; Tovey, MG | 1 |
| Kohen, KR; Levine, RA; Ramsay, CE; Schwartzel, EH | 1 |
| Davis, BB; Rapp, NS; Zenser, TV | 1 |
| Boeynaems, JM; Dumont, JE; Erneux, C; Miot, F | 1 |
| Alberts, P; Stjärne, L | 1 |
| Dowd, F; Jacobson, KL; Watson, EL | 1 |
| Flockerzi, V; Hofmann, F; Pfitzer, G; Rüegg, JC | 1 |
| Amakawa, T; Hayashi, F; Inoue, H; Takagi, M; Yoshioka, T | 1 |
| Bartfai, T; Lazaridis, G; Tjörnhammar, ML | 1 |
| Kopf, GS; Lewis, CA; Vacquier, VD | 1 |
| Cameron, CM; Rillema, JA | 1 |
| Quenzer, LF; Volle, RL | 1 |
| Waloga, G | 1 |
| Barzen, KA; Lafferty, JL; Quissell, DO | 1 |
| Beyer, C; Fernández-Guasti, A; Rodríguez-Manzo, G | 1 |
| Daniel, JW; Oleinick, NL | 1 |
| Evans, PD | 1 |
| Bousseau-Lafortune, S; Coquil, JF; Franks, DJ; Hamet, P; Tremblay, J | 1 |
| Braquet, P; Dagher, G; Diez, J; Garay, R; Hannaert, P; Nazaret, C | 1 |
| Blazynski, C; Cohen, AI | 1 |
| Matsuura, M | 1 |
| Soliman, S | 1 |
| Dartt, DA; Donowitz, M; Joshi, VJ; Mathieu, RS; Sharp, GW | 1 |
| Dobbins, JW; Forrest, JN; Laurenson, JP | 1 |
| Brown, JE; Kaupp, UB; Malbon, CC | 1 |
| Connor, JA; Hockberger, P | 2 |
| Aloj, SM; Brandi, ML; Kohn, LD; Lopponi, A; Rotella, CM; Toccafondi, R | 1 |
| Adzick, NS; Bealer, JF; Harrison, MR; VanderWall, KJ | 1 |
| Giles, WR; Han, X; Shimoni, Y | 1 |
| Fujitani, Y; Karaki, H; Okada, T; Ueda, H; Urade, Y | 1 |
| de Vente, J; Sanders, KM; Shuttleworth, CW; Ward, SM; Xue, C | 1 |
| Angielski, S; Lewko, B; Stepinski, J; Wendt, U | 1 |
| Zufall, F | 1 |
| Bertaccini, G; Coruzzi, G; Poli, E; Pozzoli, C | 1 |
| Boucher, RC; Geary, CA; Goy, MF | 1 |
| Craven, PA; DeRubertis, FR; Studer, RK | 1 |
| Ando, J; Kamiya, A; Korenaga, R; Sakuma, I; Toyo-oka, T; Tsuboi, H; Yang, W | 1 |
| Ahmad, I; Barnstable, CJ; Kocsis, JD; Leinders-Zufall, T; Shepherd, GM; Zufall, F | 1 |
| Kennedy, MW; Kusel, JR; Proudfoot, L; Smith, HV | 1 |
| Anfossi, G; Cavalot, F; Massucco, P; Mattiello, L; Mularoni, E; Trovati, M | 2 |
| Raiteri, M; Vallebuona, F | 1 |
| Cockram, CS; Ho, SK; Leung, DH; Nicholls, MG; Stadlin, A; Yeung, VT | 1 |
| Marumo, F; Nonoguchi, H; Owada, A; Sakamoto, H; Terada, Y; Tomita, K | 1 |
| De Kimpe, SJ; Nijkamp, FP; Radomski, MW; van Amsterdam, JG; Van Heuven-Nolsen, D | 1 |
| Gorczyca, WA; Palczewski, K; Van Hooser, JP | 1 |
| Catravas, JD; Cheng, C; Marczin, N; Milici, A; Papapetropoulos, A; Snead, MD | 1 |
| Baba, A; Gotoh, M; Hayata, K; Kitanaka, J; Matsuda, T; Takuma, K; Yoshikawa, T | 1 |
| Satoh, K; Taira, N; Yamagishi, T; Yanagisawa, T | 1 |
| Beusenberg, FD; Bonta, IL; Hoogsteden, HC; van Amsterdam, JG | 1 |
| Alexander, SP; Hernández, F; Kendall, DA | 1 |
| Frelin, C; Lund, L; Vigne, P | 1 |
| Gögelein, H; Popp, R; Schölkens, BA; Wiemer, G | 1 |
| Hartell, NA | 2 |
| Alessio, P; Bussolino, F; Calvino, R; Fruttero, R; Gasco, A; Ghigo, D; Heller, R; Pescarmona, G; Till, U; Todde, R | 1 |
| Bergamaschi, M; Bongrani, S; Caruso, P; Civelli, M; Gasco, A; Giossi, M; Razzetti, R | 2 |
| Alkon, DL; Inoue, H; Kouchi, T; Sakakibara, M; Yoshioka, T | 1 |
| Shaul, PW; Wells, LB | 1 |
| de Bessé, N; Lachaise, F; Saïdi, B; Sedlmeier, D; Webster, SG | 1 |
| Armstead, WM; Leffler, CW; Parfenova, H; Shibata, M; Zuckerman, SL | 1 |
| Amirchetty-Rao, S; Kendall, DA; Wright, IK | 1 |
| Bottari, SP; Brechler, V; De Gasparo, M; Levens, NR | 1 |
| Halldorsson, H; Kjeld, M; Magnusson, A; Thorgeirsson, G | 1 |
| Finkelman, F; Fong, M; Kambayashi, T; Patil-Koota, V; Strassmann, G | 1 |
| McKenna, TM; Tao, S | 1 |
| Aptel, HB; Deacon, CF; Henderson, IW | 1 |
| Cramb, G; Gilkes, AF; Guild, SB | 1 |
| Ko, FN; Kuo, SC; Lee, FY; Teng, CM; Wu, CC | 1 |
| Ashikaga, T; Kishi, Y; Numano, F; Watanabe, R | 1 |
| Angelini, GD; Newby, AC; Soyombo, AA | 1 |
| Chiba, S; Iwatsuki, K; Ren, LM | 1 |
| Assmann, SM; Li, W; Luan, S; Schreiber, SL | 1 |
| Glusa, E | 1 |
| Bergh, CM; Brophy, CM; Dransfield, DT; Goldenring, JR; Lincoln, T; Rasmussen, H | 1 |
| Ikeda, K; Sunose, H; Suzuki, M; Takasaka, T | 1 |
| Chik, CL; Ho, AK; Murdoch, G; Ogiwara, T | 1 |
| Akesson, B; Lundquist, I; Panagiotidis, G; Rydell, EL | 1 |
| Ikeda, M; Ikeda, U; Kano, S; Ohkawa, F; Shimada, K | 1 |
| Chik, CL; Ho, AK | 1 |
| Koutalos, Y; Nakatani, K; Yau, KW | 2 |
| Patel, MJ; Rimele, TJ; Rose, DA; Wiseman, JS; Wypij, DM | 1 |
| Hong, CY; Huang, YT; Lin, HC; Lo, JW; Tsai, YT; Yang, MC | 1 |
| Lefebvre, RA; Smits, GJ | 1 |
| Hara, N; Ichinose, M; Sawada, M | 1 |
| Bousquet, J; Dugas, B; Paul-Eugène, N; Pène, J | 1 |
| Noma, A; Ono, K | 1 |
| Bartoli, F; Billiar, TR; Di Silvio, M; Dorko, K; Freeswick, P; Geller, DA; Liu, ZZ; Nussler, AK | 1 |
| Kanno, M; Nakaya, H; Takeda, Y; Tohse, N | 1 |
| Barbier, AJ; Lefebvre, RA | 1 |
| Usachev, Y; Verkhratsky, A | 1 |
| Eneroth, PH; Nilsson, CG; Xiao, L | 1 |
| Kangawa, K; Matsukura, S; Matsuo, H; Miyazato, M; Nakazato, M; Yamaguchi, H | 1 |
| Cahill, PA; Hassid, A | 1 |
| Kolb, H; Kolb-Bachofen, V; Kröncke, KD; Rodriguez, ML | 1 |
| Cunningham, JM; Delaney, CA; Green, IC; Karmiris, V; Southern, C | 1 |
| Barnette, MS; Barone, FC; Manning, CD; Price, WJ | 1 |
| Alexandre, A; Deana, R; Doni, MG; Francesconi, MA; Padoin, E | 1 |
| Käppler, K; McArdle, CA; Poch, A | 1 |
| Patel, TB; Rashed, HM; Sun, H | 1 |
| Damais, C; Frelin, C; Vigne, P | 1 |
| Hagiwara, H; Hirose, S; Ito, T; Katafuchi, T | 1 |
| Blum, G; Caramelo, C; Casado, S; Gallego, MJ; López Farré, A; Montón, M; Riesco, A | 1 |
| Fabczak, H; Fabczak, S; Song, PS; Tao, N | 1 |
| Kasuya, Y; Masuda, Y; Sakai, T; Tanaka, S; Yamashita, T | 1 |
| Ikeda, M; Kaji, K; Morita, I; Murota, S; Nagao, M; Sato, I | 1 |
| Matsuda, Y; Mukhopadhyay, AK; Schumacher, H | 1 |
| Burnside, B; Liepe, BA | 1 |
| De Vente, J; Furness, JB; McConalogue, K; Young, HM | 1 |
| Spessert, R; Vollrath, L | 1 |
| Babcock, DF; Cook, SP | 1 |
| Carreau, A; Nowicki, JP; Scatton, B; Vigé, X | 1 |
| Moreau, M; Mubagwa, K; Pappano, AJ; Shirayama, T | 1 |
| Bloch, DB; Bloch, KD; Janssens, SP; Shimouchi, A; Zapol, WM | 1 |
| D'Souza, T; Dryer, SE | 1 |
| Chaudhuri, G; Chopra, M; Gryglewski, R; Ignarro, LJ; Radziszewski, W; Zembowicz, A | 1 |
| Paulding, WR; Sumners, C | 1 |
| Chang, EB; De Jonge, HR; De Vente, J; Musch, MW; Vaandrager, AB; Wilson, KT | 1 |
| Grune, S; Jameson, HL; Myers, NC; Sawkat-Anwer, M | 1 |
| Miras-Portugal, MT; Rodriguez-Pascual, F; Torres, M | 1 |
| Bendig, J; Dzeja, C; Frings, S; Hagen, V; Kaupp, UB; Krause, E | 1 |
| Telfer, WH; Wang, Y | 1 |
| Folts, JD; Keaney, JF; Loscalzo, J; Marks, DS; Vita, JA; Welch, GN | 1 |
| Akamatsu, N; Inenaga, K; Yamashita, H | 1 |
| Couser, WG; Humphreys, MH; Ling, KT; Qiu, C; Sechi, LA; Valentin, JP; Ying, WZ | 1 |
| Akai, Y; Amemiya, M; Asano, Y; Homma, S; Kusano, E; Ono, S; Takeda, S | 1 |
| DeSantis, L; Matsumoto, S; Pang, IH; Shade, DL; Steely, HT | 1 |
| Brockway, PD; Gall, DG; Hardin, JA | 1 |
| de Vente, J; Hopkins, DA; Markerink-van Ittersum, M; Steinbusch, HW | 1 |
| Pearce, WJ; White, CR | 1 |
| Abe, M; Arai, J; Asami, K; Kusunoki, S; Miyashita, Y; Moriya, T | 1 |
| Dun, NJ; Wu, SY | 1 |
| Cao, L; Cheng, Y; Gardner, DG; Humphreys, MH; Ni, X | 1 |
| Chou, TC; Ding, YA; Hong, HJ; Wu, CC; Yen, MH | 1 |
| Baudouin, B; Géniteau-Legendre, M; Millul, V; Prié, D; Ronco, PM; Verpont, MC | 1 |
| Davis, P; Gossell, M; Powell, N; Simon, OR | 1 |
| Duvilanski, BH; Lasaga, M; Pisera, D; Seilicovich, A; Zambruno, C | 1 |
| Pappano, AJ; Shirayama, T | 1 |
| Graham, A; Owen, JS; Riddell, DR | 1 |
| Bicker, G; De Vente, J; Schmachtenberg, O | 1 |
| Habuchi, Y; Lu, LL; Nishio, M; Tanaka, H; Yamamoto, T; Yoshimura, M | 1 |
| Garvin, JL; Stoos, BA | 2 |
| Brown, JC; Burns, DM; Dykes, EL; Flitney, FW; Hirst, DG; Kennovin, GD; Ruddock, MW | 1 |
| Joyner, RW; Kumar, R; Namiki, T | 1 |
| De Vente, J; Markerink-van Ittersum, M; Steinbusch, HW; Tanaka, J | 1 |
| Basten, GP; Holland, ED; Knox, AJ; Range, SP | 1 |
| Agulló, L; García, A | 1 |
| Crilley, CT; Garcia, R | 1 |
| McCaslin, PP; Oh, S; Tokuyama, S | 1 |
| Kinnamon, SC; Mackay-Sim, A; Ogura, T | 1 |
| Deschepper, CF; Gonçalves, J; Grove, KL; Picard, S; Thibault, G | 1 |
| Greer, CA; Leinders-Zufall, T; Rand, MN; Shepherd, GM; Zufall, F | 1 |
| Branka, JE; Jarry, A; Laboisse, CL; Vallette, G | 1 |
| Laitinen, JT; Laitinen, KS; Salovaara, K; Severgnini, S | 1 |
| Dun, NJ; Dun, SL; Förstermann, U; Wu, SY | 1 |
| Bakre, MM; Visweswariah, SS | 1 |
| Miller, BJ; Robinson, KR | 1 |
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| Agulló, L; Baltrons, MA; García, A; Saadoun, S | 1 |
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| Aragonés, MD; Catalán, RE; Lombardía, M; Martínez, AM | 1 |
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| Barber, DA; Crotty, TB; Gloviczki, P; Katusic, ZS; Kullo, IJ; Mozes, G; O'Brien, T; Schwartz, RS | 1 |
| Hamad, AM; Holland, E; Knox, AJ; Range, S | 1 |
| Copenhagen, DR; Dixon, DB | 1 |
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| Fabiano, C; Ientile, R; Macaione, S; Macaione, V; Pedale, S; Picciurro, V | 1 |
| Earm, YE; Han, J; Ho, WK; Kim, E; Lee, SH; Yoo, S | 1 |
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| Friebe, A; Koesling, D; Müllershausen, F; Schultz, G; Smolenski, A; Walter, U | 1 |
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| Cohen, RA; Griswold, MC; Komalavilas, P; Lincoln, TM; Weisbrod, RM; Yaghoubi, M | 1 |
| Drummer, C; Gerzer, R; Herten, M; Lenz, W | 1 |
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| Axer, H; de Vente, J; Emson, PC; Markerink-van Ittersum, M; Steinbusch, HW; van Abeelen, J | 1 |
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| Steinbusch, HW | 1 |
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| Bell, EL; Doyle, DD; Palfrey, HC; Upshaw-Earley, J | 1 |
| Lugnier, C; Marthan, R; Pauvert, O; Rousseau, E; Salvail, D; Savineau, JP | 1 |
| Bruno, GA; Ferri, M; Martina, V; Origlia, C; Pescarmona, GP; Zumpano, E | 1 |
| Harayama, H; Kato, S | 1 |
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| Bloodsworth, A; Clark, SR; Coles, B; Cross, AR; Freeman, BA; Lewis, MJ; O'Donnell, VB | 1 |
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| Beijnen, JH; Borst, P; Reid, G; van der Heijden, I; Wielinga, PR; Wijnholds, J | 1 |
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| Delbecque, JP; Gautron, F; Manière, G; Vanhems, E | 1 |
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| Chung, C; MacNeil, DJ; Morin, NR; Patel, S; Scapin, G; Singh, SB; Tota, MR; Van der Ploeg, LH; Varnerin, JP | 1 |
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| Barrand, MA; Hladky, SB; Klokouzas, A; van Veen, HW; Wu, CP | 1 |
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| Corbin, JD; Francis, SH; Huai, Q; Ke, H; Liu, Y | 1 |
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| Puggina, E; Sellitti, D | 1 |
| Bah, MM; Deptula, K; Lee, HY; Okuda, K; Skarzynski, DJ; Woclawek-Potocka, I | 1 |
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| Fujita-Yoshigaki, J; Furuyama, S; Michikawa, H; Sugiya, H; Yoshigaki, T | 1 |
| Ahmed, Z; Batchelor, AM; Cuzner, ML; Garthwaite, G; Garthwaite, J; Goodwin, DA; Hewson, AK; Leeming, K | 1 |
| Agulló, L; Escalona, N; Garcia-Dorado, D; Inserte, J; Mirabet, M; Ruiz-Meana, M; Soler-Soler, J | 1 |
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| Berkova, Z; Hassell, KA; Morris, AP; Piggott, LA; Rich, TC; Silberbach, M | 1 |
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| Kaneda, T; Konno, Y; Nakajyo, S; Shimizu, K; Urakawa, N | 1 |
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3 review(s) available for 1-methyl-3-isobutylxanthine and cyclic gmp
| Article | Year |
|---|---|
Potential role of cyclic nucleotides in glomerular pathophysiology.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cholera Toxin; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Kidney Cortex; Kidney Diseases; Kidney Failure, Chronic; Kidney Glomerulus; Kidney Tubules; Rats | 1980 |
Phosphodiesterase inhibitors as tools in cyclic nucleotide research: a precautionary comment.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Cyclic AMP; Cyclic GMP; Isoenzymes; Phosphodiesterase Inhibitors; Theophylline; Xanthines | 1981 |
Cyclic AMP-gated cation channels of olfactory receptor neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cations; Cations, Divalent; Cell Membrane; Cyclic AMP; Cyclic GMP; Ion Channel Gating; Ion Channels; Membrane Potentials; Neurons; Odorants; Second Messenger Systems; Signal Transduction; Smell; Urodela | 1993 |
579 other study(ies) available for 1-methyl-3-isobutylxanthine and cyclic gmp
| Article | Year |
|---|---|
Cholinergic stimulation of skeletal muscle alanine and glutamine formation and release. Evidence for mediation by a nicotinic cholinergic receptor and guanosine 3':5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Alanine; Animals; Atropine; Carbachol; Cyclic AMP; Cyclic GMP; Glutamine; Hexamethonium Compounds; Muscles; Phosphorylases; Pilocarpine; Quaternary Ammonium Compounds; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Theophylline | 1978 |
Effect of a phosphodiesterase inhibitor on cyclic GMP changes induced by muscarinic agonists in mouse neuroblastoma cells [proceedings].
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic GMP; Mice; Neuroblastoma; Parasympathomimetics; Theophylline | 1978 |
Cyclic GMP binding and cyclic GMP phosphodiesterase in rat platelets.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Carrier Proteins; Cyclic GMP; Dithiothreitol; Hydrogen-Ion Concentration; Mercaptoethanol; Protein Binding; Protein Kinases; Rats | 1978 |
Effect of vasoactive intestinal peptide (VIP) and other peptides on cAMP accumulation in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brain; Calcium; Cyclic AMP; Cyclic GMP; Flupenthixol; Gastrointestinal Hormones; In Vitro Techniques; Male; Peptides; Rats; Vasoactive Intestinal Peptide | 1978 |
Role of cyclic AMP in the regulation of renin release from the isolated perfused rat kidney.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Glomerular Filtration Rate; Isoproterenol; Kidney; Male; Rats; Renin; Sodium | 1978 |
Inhibition of toad urinary bladder sodium transport by carbamylcholine: possible role of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Aldosterone; Animals; Biological Transport, Active; Bufo marinus; Calcimycin; Carbachol; Cyclic GMP; In Vitro Techniques; Sodium; Urinary Bladder; Vasopressins | 1978 |
Effects of phosphodiesterase inhibitors, imidazole and phosphate on cyclic CMP phosphodiesterase are different from those on cyclic AMP and cyclic GMP phosphodiesterases.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Imidazoles; Liver; Male; Myocardium; Organ Specificity; Papaverine; Phosphates; Phosphodiesterase Inhibitors; Rats; Theophylline | 1978 |
A possible role for cyclic GMP in mediating the effect of luteinizing hormone releasing hormone on gonadotropin release in dispersed pituitary cells of the female rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Pituitary Gland, Anterior; Rats; Theophylline | 1978 |
Changes in histamine and cyclic nucleotide levels after bronchoprovocation in patients with extrinsic asthma.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Allergens; Asthma; Bronchial Spasm; Cyclic AMP; Cyclic GMP; Female; Histamine; Histamine Release; Humans; Isoproterenol; Leukocytes; Male; Middle Aged; Peak Expiratory Flow Rate; Phosphodiesterase Inhibitors; Receptors, Adrenergic, beta | 1978 |
Effects of ouabain on insulin release, adenosine 3',5'-monophosphate and guanine 3',5'-monophosphate in pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Obese; Ouabain | 1979 |
Release of growth hormone from purified somatotrophs: role of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Growth Hormone; Male; Pituitary Gland, Anterior; Prostaglandins E; Rats; Somatostatin | 1979 |
Methacholine-induced attenuation of methylisobutylxanthine- and isoproterenol-elevated cyclic AMP levels in isolated rat atria.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Electric Stimulation; Female; In Vitro Techniques; Isoproterenol; Methacholine Compounds; Myocardium; Rats; Theophylline | 1979 |
Molecular control of rabbit follicular testosterone production: role of cyclic AMP and cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Female; Ovary; Protein Biosynthesis; Puromycin; Rabbits; RNA; Testosterone; Theophylline | 1979 |
Activation of sperm respiration by a low molecular weight egg factor and by 8-bromoguanosine 3',5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acids; Cyclic AMP; Cyclic GMP; Female; Kinetics; Male; Ovum; Oxygen Consumption; Peptides; Sea Urchins; Spermatozoa; Structure-Activity Relationship | 1979 |
Cyclic GMP System in epidermis: I. Effect of ischemia.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cells, Cultured; Culture Media; Cyclic GMP; Skin; Swine | 1979 |
Evidence for involvement of cyclic nucleotides in intrinsic factor secretion by isolated rabbit gastric mucosa.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cimetidine; Cyclic AMP; Cyclic GMP; Gastric Mucosa; Histamine; In Vitro Techniques; Intrinsic Factor; Rabbits | 1979 |
Inhibition by non-steroidal anti-inflammatory agents of the ascorbate-induced elevations of platelet cyclic AMP levels.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 5,8,11,14-Eicosatetraynoic Acid; Anaerobiosis; Ascorbic Acid; Aspirin; Blood Platelets; Cyclic GMP; Enzyme Activation; Humans; Oxygen Consumption; Phospholipases A; Phospholipases A2 | 1979 |
Role of cyclic GMP in submandibular gland secretion.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Calcium; Carbachol; Cyclic GMP; Egtazic Acid; In Vitro Techniques; Male; Parasympathomimetics; Rats; Stimulation, Chemical; Submandibular Gland; Sympathomimetics | 1979 |
The effects of adenosine- and guanosine 3',5'-phosphoric acid benzyl esters on guinea-pig ventricular myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Guinea Pigs; Half-Life; In Vitro Techniques; Myocardial Contraction; Phosphodiesterase Inhibitors; Stimulation, Chemical; Time Factors | 1979 |
Dissimilar cyclic nucleotide phosphodiesterase activities in subcellular fractions from normal and SV40-transformed WI-38 fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Cell Line; Cell Transformation, Viral; Chromatography, DEAE-Cellulose; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Fibroblasts; Humans; Kinetics; Papaverine; Simian virus 40; Subcellular Fractions | 1979 |
Regulation of neuronal nitric oxide and cyclic GMP formation by Ca2+.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Calcium; Calmodulin; Cyclic GMP; Cytosol; Dose-Response Relationship, Drug; Down-Regulation; Female; Male; Molecular Sequence Data; Neurons; Nitric Oxide; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Rats; Synaptosomes | 1992 |
Molybdate increases intracellular 3',5'-guanosine cyclic monophosphate and stabilizes vitamin D receptor association with tubulin-containing filaments.
Topics: 1-Methyl-3-isobutylxanthine; Actin Cytoskeleton; Animals; Calcitriol; Cell Line; Cell Nucleus; Cyclic GMP; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Humans; Kinetics; Molybdenum; Nocodazole; Receptors, Calcitriol; Receptors, Steroid; Time Factors; Tubulin; Tumor Cells, Cultured | 1992 |
Stimulation of endothelial autacoid formation by inhibitors of angiotensin-converting enzyme.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Calcium; Cells, Cultured; Cyclic GMP; Enalaprilat; Endothelium, Vascular; Epoprostenol; Humans; Isoquinolines; Kinetics; Peptidyl-Dipeptidase A; Ramipril; Tetrahydroisoquinolines; Umbilical Veins | 1992 |
Inhibition of proliferation, but not of Ca2+ mobilization, by cyclic AMP and GMP in rabbit aortic smooth-muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Aorta; Calcium; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Muscle, Smooth; Platelet-Derived Growth Factor; Rabbits; Serotonin | 1992 |
Specific endothelin binding sites in renal medullary collecting duct cells: lack of interaction with ANP binding and cGMP signalling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Autoradiography; Body Water; Chromatography, High Pressure Liquid; Cyclic AMP; Cyclic GMP; Dogs; Endothelins; Female; Guanylate Cyclase; In Vitro Techniques; Iodine Radioisotopes; Kidney Medulla; Kidney Tubules, Collecting; Male; Receptors, Endothelin; Signal Transduction; Sodium | 1992 |
Photosensitivity of 8BrcGMP-induced conductance in ROS-excised patches.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; In Vitro Techniques; Light; Rod Cell Outer Segment; Signal Transduction; Xenopus laevis | 1992 |
Atrial natriuretic peptide effects in AtT-20 pituitary tumour cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Atrial Natriuretic Factor; Calcium; Cell Membrane Permeability; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic GMP; Hypothalamo-Hypophyseal System; Mice; Nitroprusside; Pituitary Neoplasms; Receptors, Atrial Natriuretic Factor; Tumor Cells, Cultured | 1992 |
Stimulation of testosterone production by atrial natriuretic peptide in isolated mouse Leydig cells results from a promiscuous activation of cyclic AMP-dependent protein kinase by cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Cell-Free System; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Leydig Cells; Male; Mice; Peptide Fragments; Protein Kinases; Second Messenger Systems; Testosterone; Thionucleotides | 1992 |
Bradykinin inhibition of cyclic AMP accumulation in D384 astrocytoma cells. Evidence against a role of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Arginine; Astrocytoma; Bradykinin; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Hydroxylamine; Hydroxylamines; Kinetics; NG-Nitroarginine Methyl Ester; Nitroprusside; Pyrrolidinones; Rolipram; Tumor Cells, Cultured | 1992 |
Characterization of some biochemical properties of bradykinin-induced cAMP and cGMP formation in guinea pig ileum.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Atropine; Bradykinin; Calcium; Cyclic AMP; Cyclic GMP; Dexamethasone; Egtazic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Kinetics; Male; Propranolol; Prostaglandins | 1992 |
Nonrandom structures in the locomotor behavior of Halobacterium: a bifurcation route to chaos?
Topics: 1-Methyl-3-isobutylxanthine; Cyclic GMP; Halobacterium; Light; Movement; Periodicity | 1992 |
Phosphodiesterases in vascular endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Kinetics; Milrinone; Muscle, Smooth, Vascular; Pyridones | 1992 |
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Chloride; Calmodulin; Chromatography, Ion Exchange; Cyclic GMP; Cytosol; Dipyridamole; Heart Atria; Heart Ventricles; Kinetics; Myocardium; Papaverine; Purinones; Pyrrolidinones; Rana esculenta; Rana ridibunda; Rolipram; Substrate Specificity; Theophylline | 1992 |
Rapid effects of insulin on cyclic GMP location in an intact protozoan.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Membrane; Cilia; Cyclic GMP; Cytoplasm; Insulin; Nitroprusside; Tetrahymena pyriformis; Tissue Distribution | 1992 |
Modulation of hypothalamic norepinephrine release by atrial natriuretic peptide: involvement of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Hypothalamus; In Vitro Techniques; Kinetics; Male; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Second Messenger Systems; Stimulation, Chemical; Tritium | 1992 |
Sodium nitroprusside increases cyclic GMP in fetal rat bone cells and inhibits resorption of fetal rat limb bones.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Bone and Bones; Bone Resorption; Calcitriol; Cyclic AMP; Cyclic GMP; Extremities; Fetus; Nitroprusside; Parathyroid Hormone; Radioimmunoassay; Rats | 1992 |
Endothelial cGMP does not regulate basal release of endothelium-derived relaxing factor in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Vasodilator Agents | 1992 |
Cardiovascular cyclic nucleotide phosphodiesterases and their role in regulating cardiovascular function.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Heart Failure; Humans; Isoenzymes; Kinetics; Milrinone; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardial Infarction; Myocardium; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridones; Rats | 1992 |
Agents that affect calcium influx can change cyclic nucleotide levels in cultured chick pineal cells.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Egtazic Acid; Kinetics; Nitrendipine; Pineal Gland | 1992 |
Two pathways of cyclic GMP production through glutamate receptor-mediated nitric oxide synthesis.
Topics: 1-Methyl-3-isobutylxanthine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cyclic GMP; Cycloleucine; Ibotenic Acid; In Vitro Techniques; Male; Nitric Oxide; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Glutamate | 1992 |
Cyclic nucleotides mediate an odor-evoked potassium conductance in lobster olfactory receptor cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Electric Conductivity; Nephropidae; Odorants; Olfactory Pathways; Potassium; Signal Transduction | 1992 |
Positively cooperative cAMP phosphodiesterase attenuates cellular cAMP responses.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Epinephrine; Tumor Cells, Cultured | 1992 |
Atrial natriuretic factor alters phospholipid metabolism in mesangial cells.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Atrial Natriuretic Factor; Calcimycin; Calcium; Cells, Cultured; Cyclic GMP; Glomerular Mesangium; Inositol; Inositol Phosphates; Kinetics; Male; Muscle, Smooth; Nitroprusside; Phosphatidylinositols; Phospholipids; Rats; Rats, Inbred Strains | 1990 |
Excised patches of plasma membrane from vertebrate rod outer segments retain a functional phototransduction enzymatic cascade.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cell Membrane; Cyclic GMP; Electric Conductivity; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylate Cyclase; In Vitro Techniques; Light; Lizards; Photoreceptor Cells; Signal Transduction; Thionucleotides; Vision, Ocular | 1990 |
Cyclic nucleotide responses in control and cystic fibrosis labial glands.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Cyclic AMP; Cyclic GMP; Cystic Fibrosis; Female; Humans; Lip; Male; Nucleotides, Cyclic; Reference Values; Salivary Glands; Stimulation, Chemical | 1990 |
Atriopeptins and nitroprusside provoke opposite changes in cGMP and cAMP levels in human macrophages.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Atrial Natriuretic Factor; Cyclic AMP; Cyclic GMP; Ferricyanides; GTP-Binding Proteins; Guanylate Cyclase; Humans; In Vitro Techniques; Macrophages; Nitroprusside; Proteins; Second Messenger Systems | 1990 |
Inhibition by cyclic GMP-dependent protein kinase of a histamine- and guanyl nucleotide-induced calcium permeability in pig aortic microsomes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Calcium; Cyclic GMP; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Histamine; In Vitro Techniques; Microsomes; Muscle, Smooth, Vascular; Permeability; Protein Kinases; Swine | 1990 |
Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells.
Topics: 1-Methyl-3-isobutylxanthine; Aminobutyrates; Animals; Cell Membrane; Cyclic GMP; Electric Conductivity; Glutamates; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Photoreceptor Cells; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Second Messenger Systems; Thionucleotides; Urodela | 1990 |
Interleukin 1 and endotoxin activate soluble guanylate cyclase in vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Aorta; Cyclic GMP; Endothelium, Vascular; Endotoxins; Enzyme Activation; Guanylate Cyclase; Interleukin-1; Male; Methylene Blue; Muscle, Smooth, Vascular; Myocardial Contraction; Rats; Rats, Inbred Strains; SRS-A; Time Factors; Vasodilation | 1990 |
Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/C 3T3 fibroblasts by a cyclic GMP-independent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Ascorbic Acid; Cell Division; Cell Line; Cyclic GMP; DNA; Dose-Response Relationship, Drug; Hemoglobins; Isosorbide Dinitrate; Mice; Mitosis; Muscle, Smooth, Vascular; Nitric Oxide; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine | 1990 |
Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cattle; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, High Pressure Liquid; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Kinetics; Lung; Molecular Weight; Protein Binding | 1990 |
17 beta-estradiol depolarization of hypothalamic neurons is mediated by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Colforsin; Cyclic AMP; Cyclic GMP; Drug Implants; Electric Conductivity; Estradiol; Female; Guinea Pigs; Hypothalamus; Imidazoles; Membrane Potentials; Neurons; Ovariectomy; Potassium; Theophylline | 1990 |
Cyclic GMP mediates SIN-1-induced inhibition of human polymorphonuclear leukocytes.
Topics: 1-Methyl-3-isobutylxanthine; Cyanides; Cyclic AMP; Cyclic GMP; Glucuronidase; Humans; In Vitro Techniques; Macrophage Activation; Methylene Blue; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroglycerin; Nitroprusside; Nitrosamines; Vasodilator Agents | 1990 |
Mechanism of atrial natriuretic factor-induced inhibition of rat mesangial cell mitogenesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cell Division; Cell Line; Cells, Cultured; Cyclic GMP; DNA Replication; Dose-Response Relationship, Drug; Glomerular Mesangium; Kinetics; Male; Mice; Nitroprusside; Rats; Rats, Inbred Strains; Thymidine | 1990 |
Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium Channels; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Milrinone; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Rana esculenta | 1990 |
Proctor award and lecture. William H. Miller.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Awards and Prizes; Connecticut; Cyclic GMP; Dark Adaptation; History, 20th Century; Ophthalmology; Phosphoric Diester Hydrolases; Photoreceptor Cells; Rhodopsin; Societies, Scientific; United States | 1990 |
Cellular mechanisms that underlie bleaching and background adaptation.
Topics: 1-Methyl-3-isobutylxanthine; Adaptation, Physiological; Animals; Calcium; Cyclic GMP; Larva; Light; Photoreceptor Cells; Pigmentation; Second Messenger Systems; Time Factors; Urodela | 1990 |
Regulation of cAMP metabolism in mouse parotid gland by cGMP and calcium.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Calcium; Carbachol; Colforsin; Cyclic AMP; Cyclic GMP; Hydroxylamine; Hydroxylamines; Mice; Parotid Gland | 1990 |
Rod electroretinograms in an elevated cyclic guanosine monophosphate-type human retinal degeneration. Comparison with retinitis pigmentosa.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Animals; Cats; Child; Cyclic GMP; Electroretinography; Female; Humans; Middle Aged; Photoreceptor Cells; Retina; Retinal Degeneration; Retinitis Pigmentosa; Visual Acuity | 1990 |
Activation of membrane guanylate cyclase by an invertebrate peptide hormone.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Arthropod Proteins; Cell Membrane; Cells, Cultured; Cyclic GMP; Enzyme Activation; Ganglia, Spinal; Guanylate Cyclase; Invertebrate Hormones; Kinetics; Male; Methylene Blue; Muscle, Smooth, Vascular; Muscles; Nephropidae; Nerve Tissue Proteins; Neurons; Nitroprusside; Rats; Rats, Inbred Strains | 1990 |
Nitric oxide decreases cytosolic free calcium in Balb/c 3T3 fibroblasts by a cyclic GMP-independent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Line; Cyclic AMP; Cyclic GMP; Cytosol; Fibroblasts; Isosorbide Dinitrate; Kinetics; Mice; Mice, Inbred BALB C; Nitric Oxide; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1991 |
Effect of clonidine on second messenger systems in rat adrenal gland.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Glands; Animals; Carbachol; Clonidine; Cyclic AMP; Cyclic GMP; Phosphatidylinositols; Rats; Second Messenger Systems | 1990 |
Angiotensin II decreases cGMP levels in neuronal cultures from rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Animals, Newborn; Astrocytes; Brain Stem; Cadmium; Cadmium Chloride; Cells, Cultured; Cyclic GMP; Hypothalamus; Kinetics; Neurons; Nitroprusside; Rats; Rats, Inbred Strains; Receptors, Angiotensin | 1991 |
Effects of peptides of the secretin-glucagon family and cyclic nucleotides on tyrosine hydroxylase activity in sympathetic nerve endings.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; Heart Ventricles; Male; Nerve Endings; Nitroprusside; Protein Kinase C; Rats; Rats, Inbred Strains; Second Messenger Systems; Secretin; Sympathetic Nervous System; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1991 |
cAMP analogs and selective inhibitors used to study low Km Mucor rouxii cAMP phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Centrifugation, Density Gradient; Cyclic AMP; Cyclic GMP; Dipyridamole; Hydrolysis; Mucor; Nicotinic Acids; Papaverine; Pyridazines; Theophylline | 1990 |
Properties and distribution of cyclic AMP phosphodiesterase from rat liver.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Membrane; Chromatography; Chymotrypsin; Cyclic GMP; Indoles; Insulin; Kinetics; Liver; Microsomes, Liver; Octoxynol; Polyethylene Glycols; Pyridazines; Rats; Solubility | 1990 |
Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Channels; Cells, Cultured; Cyclic AMP; Cyclic GMP; Heart; Heart Ventricles; Kinetics; Male; Myocardium; Peptide Fragments; Protein Kinases; Rats; Rats, Inbred Strains; Ventricular Function | 1991 |
Stimulation by cGMP of apical Na channels and cation channels in toad urinary bladder.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bufo marinus; Cell Membrane; Cyclic GMP; Electric Conductivity; In Vitro Techniques; Ion Channels; Kinetics; Membrane Potentials; Sodium; Sodium Channels; Urinary Bladder | 1991 |
Characterization of ANF receptors in cultured renal cortical vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Binding, Competitive; Cells, Cultured; Cyclic GMP; Iodine Radioisotopes; Kidney Cortex; Kinetics; Male; Muscle, Smooth, Vascular; Rabbits; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface | 1991 |
Progesterone receptor regulation in uterine cells: stimulation by estrogen, cyclic adenosine 3',5'-monophosphate, and insulin-like growth factor I and suppression by antiestrogens and protein kinase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cyclic GMP; Estradiol; Estrogen Antagonists; Female; Insulin-Like Growth Factor I; Kinetics; Promegestone; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Progesterone; Uterus | 1991 |
Current recording from sensory cilia of olfactory receptor cells in situ. I. The neuronal response to cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Caffeine; Cilia; Colforsin; Cyclic AMP; Cyclic GMP; Electrophysiology; In Vitro Techniques; Nasal Mucosa; Phosphodiesterase Inhibitors; Rana esculenta; Rana ridibunda; Sensory Receptor Cells; Smell | 1991 |
Inhibition of the chick pineal rhythm in rate of thymidine incorporation by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chickens; Colforsin; Cyclic AMP; Cyclic GMP; Periodicity; Phosphodiesterase Inhibitors; Pineal Gland; Thymidine | 1991 |
Atrial natriuretic factor increases cyclic GMP and cyclic AMP levels in a directly photosensitive pineal organ.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic AMP; Cyclic GMP; Darkness; Light; Nitroprusside; Organ Culture Techniques; Pertussis Toxin; Pineal Gland; Trout; Virulence Factors, Bordetella | 1990 |
The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Blood Platelets; Cattle; Cyclic GMP; Endothelium, Vascular; Humans; In Vitro Techniques; Nitric Oxide; Nitroprusside; Oxyhemoglobins; Platelet Aggregation; Platelet Aggregation Inhibitors | 1990 |
Interleukin-1 beta induces the production of an L-arginine-derived relaxing factor from cultured smooth muscle cells from rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Arginine; Biological Assay; Cells, Cultured; Coronary Vessels; Cyclic GMP; Dogs; In Vitro Techniques; Indomethacin; Interleukin-1; Kinetics; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Stereoisomerism; Vasodilator Agents | 1991 |
Effect of atrial natriuretic factor and 8-bromo cyclic guanosine 3':5'-monophosphate on [3H]acetylcholine outflow from myenteric-plexus longitudinal muscle of the guinea pig.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Tritium | 1991 |
Activation of the sensory current in salamander olfactory receptor neurons depends on a G protein-mediated cAMP second messenger system.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Neurons; Odorants; Phosphoric Diester Hydrolases; Protein Kinases; Second Messenger Systems; Sensory Receptor Cells; Smell; Urodela | 1991 |
Evaluating atrial natriuretic peptide-induced cGMP production by particulate guanylyl cyclase stimulation in vitro and in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Cortex; Animals; Atrial Natriuretic Factor; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Guanylate Cyclase; Humans; Kidney Glomerulus; Kinetics; Muscle, Smooth, Vascular; Nitroprusside; Radioimmunoassay; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface | 1991 |
The possibility of participation of different protein kinases in the regulation of degradation of Glp6[125I]Tyr8SP6-11 with different endopeptidases in subcellular fractions of rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Brain; Cell Nucleus; Cerebral Cortex; Colforsin; Cyclic AMP; Cyclic GMP; Endopeptidases; Hippocampus; Neurotransmitter Agents; Peptide Fragments; Protease Inhibitors; Protein Kinases; Pyrrolidonecarboxylic Acid; Rats; Second Messenger Systems; Subcellular Fractions; Substance P; Synaptosomes; Tetradecanoylphorbol Acetate | 1991 |
Relaxant effects of alpha-human atrial natriuretic peptide on venous smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Carbachol; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Peptide Fragments; Purinones; Saphenous Vein; Splenic Artery; Vasodilation | 1991 |
Astrocytes are responsive to endothelium-derived relaxing factor (EDRF).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Bradykinin; Carotid Arteries; Cattle; Cells, Cultured; Cyclic GMP; Embryo, Mammalian; Endothelium, Vascular; Hemoglobins; Kinetics; Nitric Oxide; Nitroprusside; Rats; Rats, Inbred Strains | 1991 |
Identification of the novel rat liver IBMX-insensitive phosphodiesterase as a non-specific phosphodiesterase capable of hydrolysing cCMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic CMP; Cyclic GMP; Kinetics; Liver; Phosphoric Diester Hydrolases; Rats; Swine | 1991 |
Regulation by forskolin of cyclic AMP phosphodiesterase and protein kinase C activity in LLC-PK1 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Cells, Cultured; Colforsin; Cyclic GMP; Galactose; Macaca mulatta; Pregnenolone; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Distribution of cyclic AMP phosphodiesterase in microdissected periportal and perivenous rat liver tissue with different dietary states.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Membrane; Cyclic AMP; Cyclic GMP; Cytosol; Fasting; Liver; Liver Extracts; Male; Rats; Rats, Inbred Strains; Signal Transduction; Sodium Fluoride | 1991 |
Calcium feedback and sensitivity regulation in primate rods.
Topics: 1-Methyl-3-isobutylxanthine; Adaptation, Physiological; Animals; Calcium; Chlorocebus aethiops; Cyclic GMP; Darkness; Feedback; Galago; In Vitro Techniques; Light; Macaca fascicularis; Macaca mulatta; Models, Biological; Perfusion; Photic Stimulation; Photoreceptor Cells; Sodium; Temperature | 1991 |
Single odor-sensitive channels in olfactory receptor neurons are also gated by cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Ion Channel Gating; Ion Channels; Neurons, Afferent; Nucleotides, Cyclic; Odorants; Olfactory Pathways; Sensory Receptor Cells; Stimulation, Chemical | 1991 |
Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Glomerular Mesangium; Guanylate Cyclase; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
The crucial role of cyclic GMP in the eclosion hormone mediated signal transduction in the silkworm metamorphoses.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bombyx; Cyclic GMP; Dose-Response Relationship, Drug; Insect Hormones; Metamorphosis, Biological; Moths; Recombinant Proteins; Second Messenger Systems; Signal Transduction | 1991 |
Absence of implication of L-arginine/nitric oxide pathway on neuronal cell injury induced by L-glutamate or hypoxia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Brain; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Dizocilpine Maleate; Fetus; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Neurons; Nitric Oxide; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Quisqualic Acid; Rats | 1991 |
Roles of cyclic GMP and inositol trisphosphate in phototransduction of the molluscan extraocular photoreceptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Dibutyryl Cyclic GMP; Guanosine Diphosphate; Inositol 1,4,5-Trisphosphate; Iontophoresis; Membrane Potentials; Microelectrodes; Neomycin; Neurons; Pertussis Toxin; Photoreceptor Cells; Potassium Channels; Potassium Chloride; Signal Transduction; Snails; Synaptic Transmission; Thionucleotides; Virulence Factors, Bordetella | 1991 |
Structure and function studies of the cGMP-stimulated phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Binding Sites; Chromatography, High Pressure Liquid; Cyclic AMP; Cyclic GMP; Dicyclohexylcarbodiimide; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Kinetics; Peptide Fragments; Peptide Mapping; Protein Conformation | 1991 |
Light and dark active phosphodiesterase regulation in salamander rods.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic GMP; Ion Channels; Kinetics; Magnesium; Membrane Potentials; Models, Biological; Phosphoric Diester Hydrolases; Photic Stimulation; Photoreceptor Cells; Signal Transduction; Urodela | 1991 |
Differential inhibition and potentiation by cell-permeant analogues of cyclic AMP and cyclic GMP and NO-containing compounds of exocytosis in human neutrophils.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Cell Aggregation; Complement C5a; Cyanides; Cyclic AMP; Cyclic GMP; Exocytosis; Glucuronidase; Humans; In Vitro Techniques; Methylene Blue; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroprusside; Nitrous Oxide; Superoxide Dismutase | 1991 |
Nitric oxide from vascular smooth muscle cells: regulation of platelet reactivity and smooth muscle cell guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Atrial Natriuretic Factor; Blood Platelets; Cattle; Cyclic GMP; Cycloheximide; Escherichia coli; Guanylate Cyclase; Humans; In Vitro Techniques; Lipopolysaccharides; Macrophages; Mice; Monocytes; Muscle, Smooth; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; omega-N-Methylarginine; Superoxide Dismutase; Thrombin | 1991 |
Calcitonin gene-related peptide (CGRP) causes endothelium-dependent cyclic AMP, cyclic GMP and vasorelaxant responses in rat abdominal aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Abdominal; Calcitonin Gene-Related Peptide; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Indomethacin; Kinetics; Male; Muscle Relaxation; Rats; Rats, Inbred Strains; Vasodilation | 1991 |
Control of HCO3-dependent exchangers by cyclic nucleotides in vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Bicarbonates; Biological Transport, Active; Colforsin; Cyclic AMP; Cyclic GMP; Fluorescent Dyes; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Exchange; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1991 |
Effects of the cyclic nucleotide phosphodiesterase inhibitors, rolipram, 3-isobutyl-1-methylxanthine, amrinone and zaprinast, on pancreatic exocrine secretion in dogs.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amrinone; Animals; Bicarbonates; Cyclic AMP; Cyclic GMP; Dogs; Female; Male; Pancreas; Pancreatic Juice; Perfusion; Phosphodiesterase Inhibitors; Proteins; Purinones; Pyrrolidinones; Rolipram; Secretin; Sincalide | 1991 |
Cyclic nucleotides in human macrophages: effects of atrial natriuretic factor and nitroprusside on cGMP and cAMP production.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Macrophages; Nitroprusside; Nucleotides, Cyclic; Peritoneal Cavity | 1991 |
Isoprenaline-like effects of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine on mechanical, biochemical and electrophysiological parameters in the mammalian heart.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Calcium; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart; Ion Channels; Isoproterenol; Myocardial Contraction; Stimulation, Chemical; Theophylline | 1985 |
Indoleamine-sensitive adenylate cyclase in rabbit retina: characterization and distribution.
Topics: 1-Methyl-3-isobutylxanthine; 5-Methoxytryptamine; Adenylyl Cyclases; Animals; Cats; Cyclic AMP; Cyclic GMP; Guanosine Triphosphate; Haloperidol; Humans; Melatonin; Methoxydimethyltryptamines; Rabbits; Retina; Serotonin; Serotonin Antagonists; Tryptamines | 1985 |
Ca2+-dependent modulation of renin release from isolated glomeruli: apparent independence from alterations in cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Calcium; Calmodulin; Cyclic GMP; Female; In Vitro Techniques; Isoproterenol; Kidney Glomerulus; Nitroprusside; Ouabain; Potassium Chloride; Rats; Rats, Inbred Strains; Renin | 1985 |
Light-induced activation of the rod phosphodiesterase leads to a rapid transient increase of near-infrared light scattering.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cattle; Cyclic GMP; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Infrared Rays; Light; Membrane Proteins; Photoreceptor Cells; Protamines; Rhodopsin; Rod Cell Outer Segment; Scattering, Radiation; Thionucleotides; Transducin | 1985 |
Enhancement of acetylcholine-evoked catecholamine release from perfused dog adrenals by elevating cyclic AMP levels.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adrenal Glands; Animals; Catecholamines; Cholera Toxin; Cyclic AMP; Cyclic GMP; Dogs; Female; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Potassium; Spectrometry, Fluorescence | 1985 |
Role of adenosine 3',5'-cyclic monophosphate in adrenoceptor-mediated control of 3H-noradrenaline secretion in guinea-pig ileum myenteric nerve terminals.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Ileum; In Vitro Techniques; Isoproterenol; Male; Myenteric Plexus; Nerve Endings; Nicotinic Acids; Norepinephrine; Phosphodiesterase Inhibitors; Propranolol; Receptors, Adrenergic; Yohimbine | 1985 |
Cyclic GMP and acid production in isolated gastric cells of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Bucladesine; Carbachol; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Female; Gastric Acid; Histamine; In Vitro Techniques; Nitrogen; Parietal Cells, Gastric; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1985 |
Specific binding activities and cyclic GMP responses by atrial natriuretic polypeptide in kidney epithelial cell line (LLC-PK1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cell Line; Chromatography, High Pressure Liquid; Cold Temperature; Cyclic GMP; Dose-Response Relationship, Drug; Epithelium; Kidney; Peptide Fragments; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Time Factors | 1985 |
Release of growth hormone (GH) from purified somatotrophs: interaction of GH-releasing factor and somatostatin and role of adenosine 3',5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Somatostatin; Time Factors | 1985 |
Phosphorylation reactions in bovine rod outer segments studied by 32P-labelling of intact retina.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cattle; Centrifugation, Density Gradient; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Light; Membrane Proteins; Molecular Weight; Phosphorylation; Photoreceptor Cells; Retina; Rod Cell Outer Segment | 1986 |
Atrial natriuretic hormones raise the level of cyclic GMP in neural cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcimycin; Calcium; Cell Line; Cyclic GMP; Glioma; Hybrid Cells; Kinetics; Neuroblastoma; Rats | 1986 |
Phosphodiesterase inhibitors induce endothelium-dependent relaxation of rat and rabbit aorta by potentiating the effects of spontaneously released endothelium-derived relaxing factor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cyclic GMP; Drug Synergism; Endothelium; Hemoglobins; In Vitro Techniques; Isoproterenol; Male; Nitric Oxide; Nitroglycerin; Papaverine; Phosphodiesterase Inhibitors; Purinones; Rabbits; Rats; Rats, Inbred Strains; Vasodilation; Vasodilator Agents | 1986 |
Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Cattle; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Humans; Kinetics; Muscle, Smooth, Vascular; Purinones; Rats; Species Specificity; Substrate Specificity | 1986 |
Influence of papaverine on cyclic nucleotide level and cellular metabolism in rat kidney cortex in terms of its inhibitory effect on p-aminohippurate transport.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Aminohippuric Acids; Animals; Biological Transport; Calcium; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Kidney Cortex; Male; Mitochondria; Nucleotides, Cyclic; Ouabain; Oxygen Consumption; p-Aminohippuric Acid; Papaverine; Rats; Rats, Inbred Strains; Sodium; Theophylline | 1986 |
Steroid regulation of the peptide-mediated increase in cyclic GMP in the nervous system of the hawkmoth, Manduca sexta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Ganglia; Insect Hormones; Lepidoptera; Moths; Theophylline | 1985 |
Role of cAMP in modulating intrafollicular progesterone levels and oocyte maturation in amphibians (Rana pipiens).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; Female; Oocytes; Oogenesis; Ovary; Pituitary Hormones; Progesterone; Rana pipiens | 1986 |
Cyclic GMP formation and inositol phosphate accumulation do not share common origins in rat brain slices.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Cell Compartmentation; Cyclic GMP; Inositol Phosphates; Isradipine; Male; Oxadiazoles; Potassium; Rats; Rats, Inbred Strains; Sugar Phosphates; Type C Phospholipases | 1986 |
The in vitro effects of cyclic nucleotides, cyanoketone, and cycloheximide on the production of estradiol-17 beta by vitellogenic ovarian follicles of goldfish (Carassius auratus).
Topics: 1-Methyl-3-isobutylxanthine; Androstenols; Animals; Aromatase; Bucladesine; Chorionic Gonadotropin; Cyanoketone; Cyclic AMP; Cyclic GMP; Cycloheximide; Cyprinidae; Dibutyryl Cyclic GMP; Estradiol; Female; Goldfish; Nucleotides, Cyclic; Ovarian Follicle; Theophylline; Time Factors; Vitellogenesis | 1986 |
Vasopressin-mediated inhibition of atrial natriuretic factor-stimulated cGMP accumulation in an established smooth muscle cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Cell Line; Cyclic GMP; GTP-Binding Proteins; Muscle, Smooth, Vascular; Rats; Receptors, Angiotensin; Receptors, Vasopressin; Vasodilation | 1986 |
Role of cyclic GMP in atrial natriuretic factor stimulation of Na+,K+,Cl- cotransport in vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Aminoquinolines; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Carrier Proteins; Cyclic GMP; Muscle, Smooth, Vascular; Purinones; Rats; Sodium-Potassium-Chloride Symporters | 1986 |
Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Gland Neoplasms; Animals; Atrial Natriuretic Factor; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Glioma; Pheochromocytoma; Rats; Time Factors | 1987 |
Effects of cyclic nucleotide derivatives on acetylcholine-induced secretion from isolated, perfused rat submandibular salivary glands.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Bucladesine; Cyclic GMP; Isoproterenol; Male; Nucleotides, Cyclic; Rats; Rats, Inbred Strains; Saliva; Submandibular Gland; Theophylline | 1986 |
Effects of guanosine 3',5'-monophosphate on glucose utilization in isolated islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; Acetylglucosamine; Animals; Cyclic GMP; Cycloheximide; Dibutyryl Cyclic GMP; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Mannitol; Methylnitronitrosoguanidine; Rats; Rats, Inbred Strains | 1987 |
Effect of stimulated neutrophils on cyclic nucleotide content in isolated rat glomeruli.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catalase; Cyclic AMP; Cyclic GMP; Kidney Glomerulus; Lymphocyte Activation; Neutrophils; Rats; Rats, Inbred Strains; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Zymosan | 1987 |
cGMP mediates effects of atrial peptides on medullary collecting duct cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Kidney Tubules; Kidney Tubules, Collecting; Microscopy, Electron; Nitroprusside; Oxygen Consumption; Rabbits; Swine | 1987 |
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine | 1987 |
Effects of temperature on allosteric and catalytic properties of the cGMP-stimulated cyclic nucleotide phosphodiesterase from calf liver.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cattle; Cyclic AMP; Cyclic GMP; Kinetics; Liver; Solvents; Temperature; Theophylline | 1987 |
Effects of enoximone and isobutylmethylxanthine on contractile tension and cyclic nucleotide levels in isolated blood-perfused dog papillary muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dogs; Enoximone; Imidazoles; In Vitro Techniques; Myocardial Contraction; Nucleotides, Cyclic; Papillary Muscles; Theophylline | 1987 |
Opposite regulatory effects of cAMP and cGMP on sugar uptake in rat thymocytes.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Carbohydrate Metabolism; Cyclic AMP; Cyclic GMP; Deoxyglucose; Epinephrine; Female; Insulin; Osmolar Concentration; Rats; Rats, Inbred Strains; Theophylline; Thymus Gland; Triiodothyronine | 1987 |
Cyclic nucleotide potentiation of muscarinic responses in neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenine; Adenosine; Animals; Bucladesine; Cell Line; Cyclic AMP; Cyclic GMP; Dopamine; Membrane Potentials; Neurons; Receptors, Muscarinic | 1987 |
Is the muscarinic receptor that mediates potentiation of dopamine release negatively coupled to the cyclic GMP system?
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Corpus Striatum; Cyclic GMP; Dopamine; Frontal Lobe; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1987 |
Parathyroid hormone-induced changes in cyclic nucleotide levels during relaxation of the rabbit [correction of rat] aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parathyroid Hormone; Rabbits | 1987 |
Atrial natriuretic peptide effects on cGMP and cAMP contents in microdissected glomeruli and segments of the rat and rabbit nephrons.
Topics: 1-Methyl-3-isobutylxanthine; Acetylation; Animals; Atrial Natriuretic Factor; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Kidney Glomerulus; Kinetics; Nephrons; Rabbits; Rats | 1987 |
The dynamics of cGMP metabolism in neuroblastoma N1E-115 cells determined by 18O labeling of guanine nucleotide alpha-phosphoryls.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenine Nucleotides; Animals; Carbachol; Cell Line; Cyclic AMP; Cyclic GMP; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Isotope Labeling; Kinetics; Neuroblastoma; Nitroprusside; Oxygen Radioisotopes | 1987 |
Angiotensin decreases cyclic GMP accumulation produced by atrial natriuretic factor.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Aorta; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Muscle, Smooth, Vascular; Nitroprusside | 1987 |
Irreversible inhibition of calmodulin-sensitive cyclic nucleotide phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Affinity Labels; Animals; Calmodulin; Cerebral Cortex; Chymotrypsin; Cyclic AMP; Cyclic GMP; Papaverine; Photolysis; Swine; Triazines; Ultraviolet Rays | 1986 |
Potentiation of cholinergic responses in mouse parotid gland by a cAMP dependent mechanism involves cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Mice; Parasympathetic Nervous System; Parotid Gland | 1987 |
Physiological effects of carbamylcholine, cyclic GMP and related agents on isolated rat ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Carbachol; Cells, Cultured; Cyclic AMP; Cyclic GMP; Electrophysiology; Heart; Heart Rate; Isoproterenol; Myocardial Contraction; Rats | 1987 |
Mechanism for amine modulation of the neurogenic Limulus heart: evidence for involvement of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biogenic Amines; Colforsin; Cyclic AMP; Cyclic GMP; Dopamine; Heart; Horseshoe Crabs; Myocardium; Octopamine | 1987 |
Cyclic guanosine 3',5'-monophosphate regulates the calcium current in single cells from frog ventricle.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Calcium; Cyclic AMP; Cyclic GMP; Heart; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channels; Rana esculenta; Time Factors | 1987 |
Calcium in dark-adapted toad rods: evidence for pooling and cyclic-guanosine-3'-5'-monophosphate-dependent release.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bufo marinus; Calcium; Cyclic GMP; Dark Adaptation; In Vitro Techniques; Photoreceptor Cells; Retina; Time Factors | 1987 |
Study of the roles of calcium and cyclic GMP in visual transduction.
Topics: 1-Methyl-3-isobutylxanthine; Ambystoma; Animals; Bufo marinus; Calcium; Cell Separation; Cyclic GMP; In Vitro Techniques; Membrane Potentials; Models, Neurological; Photic Stimulation; Photoreceptor Cells; Subcellular Fractions | 1987 |
Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chick Embryo; Cyclic AMP; Cyclic GMP; Cycloheximide; Ganglia, Parasympathetic; Membrane Potentials; Neurons; Receptors, Cholinergic | 1987 |
Atrial natriuretic factor stimulates luteal guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Chlorides; Chorionic Gonadotropin; Corpus Luteum; Cyclic AMP; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; Manganese; Manganese Compounds; Progesterone; Rats | 1987 |
Effects of pH on allosteric and catalytic properties of the guanosine cyclic 3',5'-phosphate stimulated cyclic nucleotide phosphodiesterase from calf liver.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Allosteric Regulation; Animals; Cattle; Cyclic AMP; Cyclic GMP; Hydrogen-Ion Concentration; Kinetics; Liver; Substrate Specificity | 1987 |
Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Airway Resistance; Animals; Cyclic AMP; Cyclic GMP; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyrazines | 1987 |
Interaction of atrial natriuretic peptide-stimulated guanylate cyclase and vasopressin-stimulated calcium signaling pathways in the glomerular mesangial cell.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcium; Cells, Cultured; Cyclic GMP; Cytosol; Fluorescent Dyes; Guanylate Cyclase; Indoles; Inositol Phosphates; Kidney Glomerulus; Rats; Rats, Inbred Strains; Vasopressins | 1988 |
Effects of IBMX on the ERG of the isolated perfused cat eye.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Electroretinography; In Vitro Techniques; Photometry; Photoreceptor Cells; Retina; Theophylline; Time Factors | 1987 |
On the role of cyclic nucleotides in the pathogenesis of human atherosclerosis.
Topics: 1-Methyl-3-isobutylxanthine; Aorta; Arteriosclerosis; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic GMP; Humans; Lipid Metabolism; Organ Culture Techniques | 1987 |
Differences in the cyclic nucleotide mediation of luteinizing hormone-releasing hormone action on the rat and hamster anterior pituitary gland.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cricetinae; Cyclic GMP; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; In Vitro Techniques; Kinetics; Luteinizing Hormone; Male; Mesocricetus; Pituitary Gland, Anterior; Rats; Species Specificity; Theophylline | 1988 |
Egg-laying hormone, serotonin, and cyclic nucleotide modulation of ionic currents in the identified motoneuron B16 of Aplysia.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aplysia; Colforsin; Cyclic GMP; Electrophysiology; Invertebrate Hormones; Membrane Potentials; Motor Neurons; Serotonin | 1988 |
3':5'-cyclic GMP in the yeast Saccharomyces cerevisiae at different metabolic conditions.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic AMP; Cyclic GMP; Glucose; Guanosine Triphosphate; Oxygen; Radioimmunoassay; Saccharomyces cerevisiae; Theophylline | 1988 |
Role of phosphodiesterase in regulation of calcium current in isolated cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Ion Channels; Isoproterenol; Kinetics; Myocardium; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Ranidae | 1988 |
The effect of parathyroid hormone and atrial natriuretic peptide on cyclic nucleotides production and proliferation of avian epiphyseal growth plate chondroprogenitor cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Atrial Natriuretic Factor; Cartilage; Cells, Cultured; Chick Embryo; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic GMP; Dinoprostone; Growth Plate; Kinetics; Parathyroid Hormone; Peptide Fragments; Prostaglandins E | 1988 |
Adenosine inhibits the positive inotropic effect of 3-isobutyl-1-methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenosine; Animals; Calcium; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart; In Vitro Techniques; Myocardial Contraction; Myocardium; Papillary Muscles; Phenylisopropyladenosine; Theophylline | 1988 |
Tentacle contraction in Heliophrya erhardi (Suctoria): the role of inositol phospholipid metabolites and cyclic nucleotides in stimulus-response coupling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Chlorides; Ciliophora; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Inositol Phosphates; Lithium; Lithium Chloride; Muscle Contraction; Pyrimidinones; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thiazoles | 1988 |
Stimulation of guanylate cyclase activity by irreversible binding of atrial natriuretic peptide to its receptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface | 1988 |
Interaction of forskolin with the effect of atropine on [3H]acetylcholine secretion in guinea-pig ileum myenteric plexus.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Aminopyridines; Animals; Atropine; Colforsin; Cyclic GMP; Drug Interactions; Guinea Pigs; Ileum; In Vitro Techniques; Myenteric Plexus; Neuromuscular Junction | 1988 |
Guanosine 3',5'-cyclic monophosphate-activated conductance studied in a truncated rod outer segment of the toad.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenosine Triphosphate; Animals; Bufo marinus; Cyclic GMP; Dose-Response Relationship, Drug; Guanosine Triphosphate; In Vitro Techniques; Light; Photoreceptor Cells; Rod Cell Outer Segment; Time Factors | 1988 |
Selective inhibitors of specific phosphodiesterases in intact adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipose Tissue; Animals; Cattle; Cells, Cultured; Cyclic GMP; Dexamethasone; Insulin; Kinetics; Liver; Mice; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinolines; Quinolones; Rats; Structure-Activity Relationship | 1988 |
[Effect of cyclic nucleotides on calcium dependent K+ channels, in human erythrocytes].
Topics: 1-Methyl-3-isobutylxanthine; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Erythrocytes; Humans; Ion Channels; Potassium | 1988 |
Nerve growth factor increases the cyclic GMP level and activates the cyclic GMP phosphodiesterase in PC12 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adrenal Gland Neoplasms; Animals; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activation; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Nerve Growth Factors; Pheochromocytoma | 1988 |
Cyclic guanosine monophosphate increases hydraulic conductivity in rabbit and rat CCT.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Cyclic GMP; Hemin; In Vitro Techniques; Kidney Tubules; Kidney Tubules, Collecting; Nitroprusside; Osmolar Concentration; Rabbits; Rats; Rats, Inbred Strains; Water-Electrolyte Balance | 1988 |
Inhibition of atrial natriuretic peptide secretion by forskolin in noncontracting cultured atrial myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Atrial Natriuretic Factor; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic GMP; Egtazic Acid; Muscle Contraction; Muscle, Smooth, Vascular; Protein Kinase C; Ryanodine; Sarcoplasmic Reticulum; Secretory Rate; Tetradecanoylphorbol Acetate | 1988 |
A novel mechanism of soluble guanylate cyclase stimulation: time-dependent activation by bacterial lipopolysaccharide in rat fetal spleen cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic GMP; Cytosol; Dithiothreitol; Drug Synergism; Enzyme Activation; Gestational Age; Guanylate Cyclase; Kinetics; Lipopolysaccharides; Liver; Magnesium; Manganese; Rats; Salmonella; Spleen | 1988 |
Elevation by atrial natriuretic factors of cyclic GMP levels in astroglia-rich cultures from murine brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Atrial Natriuretic Factor; Brain; Cells, Cultured; Cyclic GMP; Kinetics; Mice; Neurons; Peptide Fragments; Rats; Rats, Inbred Strains | 1989 |
Excitation of locus coeruleus neurons by an adenosine 3',5'-cyclic monophosphate-activated inward current: extracellular and intracellular studies in rat brain slices.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Neurons; Rats; Reference Values; Theophylline | 1987 |
Leukotriene D4 inhibits atrial natriuretic factor-dependent cGMP production in rat glomerulus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; Kidney Glomerulus; Male; Nephrons; Nitroprusside; Rats; Rats, Inbred Strains; SRS-A | 1989 |
Attenuation of endotoxin-induced cytotoxicity and prostacyclin production in cultured bovine pulmonary artery endothelial cells by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; 6-Ketoprostaglandin F1 alpha; Adenylyl Cyclases; Animals; Bucladesine; Cattle; Cell Survival; Cells, Cultured; Colforsin; Cyclic GMP; Endothelium, Vascular; Ferricyanides; L-Lactate Dehydrogenase; Lipopolysaccharides; Nitroprusside; Phosphodiesterase Inhibitors; Pulmonary Artery; Theophylline | 1988 |
Effects of cyclic nucleotides and calcium/calmodulin on protein phosphorylation in the CNS of Hirudo medicinalis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calmodulin; Cyclic AMP; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Leeches; Nerve Tissue Proteins; Nervous System; Phosphoproteins; Phosphorylation; Protein Kinases; Sodium Fluoride | 1989 |
The cyclic GMP-induced inward current in neuron R14 of Aplysia californica: similarity to a FMRFamide-induced inward current.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Calcium; Chlorides; Cyclic AMP; Cyclic GMP; FMRFamide; Neural Conduction; Neuropeptides; Potassium; Sodium | 1989 |
ANP relaxes bovine tracheal smooth muscle and increases cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Carbachol; Cattle; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Histamine; In Vitro Techniques; Isoproterenol; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Serotonin; Trachea | 1989 |
Influence of cyclic nucleotides on the processing of the carbohydrate part of the alpha-subunit of human choriogonadotropin by first trimester human placenta tissue.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; alpha-Mannosidase; Carbohydrate Metabolism; Culture Techniques; Cyclic AMP; Cyclic GMP; Female; Glycoprotein Hormones, alpha Subunit; Glycosylation; Hexosaminidases; Humans; Mannose; Mannosidases; Molecular Weight; N-Acetylneuraminic Acid; Neuraminidase; Placenta; Pregnancy; Protein Biosynthesis; Protein Precursors; Sialic Acids | 1989 |
Atrial natriuretic peptide and sodium nitroprusside stimulate cyclic GMP accumulation by avian skin fibroblasts and epiphyseal growth-plate chondroprogenitor cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cells, Cultured; Chickens; Cyclic GMP; Ferricyanides; Fibroblasts; Growth Plate; Humans; Nitroprusside; Rats; Skin; Stem Cells; Time Factors | 1989 |
Indirect relationship between vasopressin-induced secretion of ACTH and cyclic nucleotides in cultured anterior pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adrenocorticotropic Hormone; Animals; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Pituitary Gland, Anterior; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Vasopressins | 1989 |
A light-induced decrease of cyclic GMP is involved in the photoresponse of molluscan extraocular photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; In Vitro Techniques; Lighting; Membrane Potentials; Mollusca; Photic Stimulation; Photoreceptor Cells | 1989 |
Adenosine-sensitive phosphoinositide turnover in a newly established renal cell line.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Cell Line; Cyclic AMP; Cyclic GMP; Cytosol; Epithelium; Kidney Tubules, Collecting; Membrane Potentials; Pertussis Toxin; Phosphatidylinositols; Rabbits; Virulence Factors, Bordetella | 1989 |
Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Arteries; Bucladesine; Calcium; Calcium Channels; Colforsin; Cyclic AMP; Cyclic GMP; GTP-Binding Proteins; In Vitro Techniques; Inositol Phosphates; Kinetics; Male; Muscle, Smooth, Vascular; Nifedipine; Potassium Chloride; Rats; Rats, Inbred Strains; Sodium Fluoride; Vasoconstriction; Verapamil | 1989 |
Control of light-sensitive current in salamander rods.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Ambystoma; Animals; Calcium; Cyclic GMP; In Vitro Techniques; Kinetics; Light; Lithium; Mathematics; Photoreceptor Cells; Sodium | 1988 |
Metabolic flux of cyclic GMP and phototransduction in rabbit retina.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Cyclic GMP; Darkness; Dose-Response Relationship, Drug; Hydrolysis; In Vitro Techniques; Light; Photochemistry; Rabbits; Retina | 1988 |
Muscarinic control of the hyperpolarization-activated current (if) in rabbit sino-atrial node myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Cyclic AMP; Cyclic GMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Membrane Potentials; Muscles; Oxotremorine; Phosphoric Diester Hydrolases; Rabbits; Receptors, Muscarinic; Sinoatrial Node; Thionucleotides | 1988 |
On the transduction mechanism of microvillar photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic GMP; Dark Adaptation; Invertebrates; Ion Channels; Membrane Potentials; Microvilli; Phosphorylation; Photoreceptor Cells; Signal Transduction; Theophylline | 1989 |
A study of the phasic response of arterioles of the guinea pig small intestine to prolonged exposure to norepinephrine.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arterioles; Clonidine; Colforsin; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Intestine, Small; Isoproterenol; Membrane Potentials; Norepinephrine; Oxidation-Reduction; Propranolol; Temperature; Theophylline; Vasoconstriction; Yohimbine | 1989 |
Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Carbamates; Cardiovascular Agents; Cyclic AMP; Cyclic GMP; Electric Stimulation; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Rabbits; Theophylline | 1989 |
Second-messenger systems underlying amine and peptide actions on cardiac muscle in the horseshoe crab Limulus polyphemus.
Topics: 1-Methyl-3-isobutylxanthine; Amines; Animals; Catecholamines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Epinephrine; Heart; Horseshoe Crabs; Myocardial Contraction; Neuropeptides; Norepinephrine; Oligopeptides; Peptides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Second Messenger Systems | 1989 |
Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Kinetics; Male; Methylene Blue; Muscle Relaxants, Central; Nitric Oxide; Phthalazines; Purinones; Pyridazines; Rats; Rats, Inbred Strains; Theophylline; Vinca Alkaloids | 1989 |
Resolution of soluble cyclic nucleotide phosphodiesterase isoenzymes, from liver and hepatocytes, identifies a novel IBMX-insensitive form.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium; Calmodulin; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Cytosol; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Theophylline | 1989 |
Characterization of MS-857, a new and potent cardiotonic agent, in isolated mammalian cardiac muscles.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cardiotonic Agents; Cats; Cyclic AMP; Cyclic GMP; Dogs; Female; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Macaca mulatta; Male; Milrinone; Myocardial Contraction; Pyridones; Rabbits; Rats; Rats, Inbred Strains; Reserpine; Tetrahydroisoquinolines | 1989 |
Mediation of muscarinic stimulation of pepsinogen secretion in the frog.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bethanechol; Bethanechol Compounds; Calcium; Cyclic AMP; Cyclic GMP; Egtazic Acid; Esophagus; In Vitro Techniques; Kinetics; Pepsinogens; Rana catesbeiana; Receptors, Muscarinic | 1985 |
The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Arrhythmias, Cardiac; Bucladesine; Coronary Disease; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Heart; Male; Myocardium; Quinazolines; Rats; Rats, Inbred Strains | 1985 |
Influence of cyclic nucleotides on receptor binding, immunological activity, and microheterogeneity of human choriogonadotropin synthesized in placental tissue culture.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chorionic Gonadotropin; Culture Techniques; Cyclic AMP; Cyclic GMP; Female; Humans; Isoelectric Focusing; Leydig Cells; Male; Mice; Nucleotides, Cyclic; Placenta; Pregnancy; Radioimmunoassay; Receptors, Cell Surface; Receptors, LH; Testosterone | 1985 |
Vascular receptor binding activities and cyclic GMP responses by synthetic human and rat atrial natriuretic peptides (ANP) and receptor down-regulation by ANP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding, Competitive; Cells, Cultured; Cyclic GMP; Kinetics; Muscle, Smooth, Vascular; Natriuretic Agents; Proteins; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface | 1985 |
Specificity of cGMP binding to a purified cGMP-stimulated phosphodiesterase from bovine adrenal tissue.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adrenal Glands; Animals; Binding Sites; Binding, Competitive; Cattle; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Hydrolysis; Protein Binding | 1985 |
Histamine modulates contraction and cyclic nucleotides in cultured rat mesangial cells. Differential effects mediated by histamine H1 and H2 receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Movement; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dimaprit; Glomerular Mesangium; Histamine; Kidney Glomerulus; Male; Rats; Rats, Inbred Strains; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Thiourea | 1985 |
Characterization of a novel cGMP binding protein from rat lung.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Binding, Competitive; Carrier Proteins; Cyclic GMP; Enzyme Activation; Kinetics; Lung; Male; Protein Kinases; Rats; Trypsin | 1980 |
Influence of isoproterenol and methylisobutylxanthine on the contractile and cyclic nucleotide effects of methacholine in isolated rat atria.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic AMP; Cyclic GMP; Depression, Chemical; Drug Interactions; Female; Heart Atria; In Vitro Techniques; Isoproterenol; Methacholine Compounds; Myocardial Contraction; Ouabain; Rats; Stimulation, Chemical; Theophylline | 1980 |
Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with angiotensin II and arginine vasopressin.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Arginine Vasopressin; Cells, Cultured; Cyclic AMP; Cyclic GMP; Kidney Glomerulus; Lypressin; Muscle Contraction; Parathyroid Hormone; Prostaglandins E, Synthetic; Rats | 1980 |
Induction of a transient elevation in intracellular levels of adenosine-3',5'-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation.
Topics: 1-Methyl-3-isobutylxanthine; Chemotactic Factors; Complement C5; Cyclic AMP; Cyclic GMP; Cytoplasmic Granules; Dose-Response Relationship, Immunologic; Humans; Kinetics; Neutrophils; Phenylalanine; Prostaglandins E; Sodium Radioisotopes; Superoxides | 1980 |
Relaxation of bovine coronary arterial smooth muscle by cyclic GMP, cyclic AMP and analogs.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Cattle; Coronary Vessels; Cyclic AMP; Cyclic GMP; Drug Interactions; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium | 1980 |
Effects of isoprenaline and 1-methyl-3-isobutylxanthine on cyclic nucleotides and cyclic AMP-dependent protein kinase in rabbit colon smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colon; Cyclic AMP; Cyclic GMP; Isoproterenol; Muscle, Smooth; Protein Kinases; Rabbits; Sodium Fluoride; Theophylline | 1980 |
Cyclic GMP-dependent protein phosphorylation in intact medial tissue and isolated cells from vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Affinity Labels; Animals; Aorta, Thoracic; Atropine; Azides; Cyclic GMP; Cyclic IMP; Male; Molecular Weight; Muscle, Smooth, Vascular; Peptide Fragments; Phosphorylation; Protein Kinases; Rabbits; Rats | 1980 |
Different effects of cAMP and cGMP derivatives on the activity of an identified neuron: biochemical and electrophysiological analysis.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine Triphosphate; Animals; Aplysia; Cyclic AMP; Cyclic GMP; Histones; Neurons; Protein Kinases; Structure-Activity Relationship | 1980 |
Effects of oxytocin and methacholine on cyclic nucleotide levels of rabbit myometrium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Drug Interactions; Female; Methacholine Compounds; Myometrium; Oxytocin; Rabbits; Uterine Contraction; Uterus | 1980 |
Activation of human lymphocyte high affinity cyclic AMP phosphodiesterase by culture with 1-methyl-3-isobutylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Adult; Azides; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Enzyme Activation; Humans; Kinetics; Lymphocytes; Theophylline | 1980 |
Enhancement by 3-isobutyl-1-methylxanthine and cholera toxin of 12-O-tetradecanoylphorbol-13-acetate-stimulated cyclic nucleotide levels and ornithine decarboxylase activity in isolated epidermal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carboxy-Lyases; Cell Separation; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cyclic GMP; Epidermis; Mice; Nucleotides, Cyclic; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate; Theophylline; Time Factors | 1980 |
Role of Ca2+ and cyclic nucleotides in the control of prostaglandin E production in the rat anterior pituitary gland.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arachidonic Acids; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Growth Hormone; In Vitro Techniques; Male; Pituitary Gland, Anterior; Potassium; Prostaglandins E; Rats; Theophylline | 1980 |
Peptide hormone regulation of programmed death of neurons and muscle in an insect.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Brain; Cell Survival; Cyclic AMP; Cyclic GMP; Insecta; Juvenile Hormones; Moths; Muscles; Neurons; Peptides | 1980 |
Inhibition by purine compounds of cyclic GMP-stimulated cyclic AMP phosphodiesterase activity from a particulate fraction of rat striatum.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Corpus Striatum; Cyclic GMP; Dose-Response Relationship, Drug; Hypoxanthines; Inosine; Male; Purines; Rats; Theophylline | 1980 |
Azide reversibly raises cyclic GMP levels in hepatic slices and activates guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Azides; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Liver; Male; Rats | 1980 |
Studies on the role of cyclic GMP in the control of human platelet function.
Topics: 1-Methyl-3-isobutylxanthine; Arachidonic Acids; Aspirin; Blood Platelets; Cyclic GMP; Humans; Indomethacin | 1980 |
Changes in membrane potential of cultured porcine and human thyroid cells in response to thyrotrophin and other agents.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Humans; Membrane Potentials; Swine; Thyroid Gland; Thyrotropin | 1981 |
Increased concentrations of cyclic GMP in fetal liver cells stimulated by erythropoietin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; DNA; Erythropoietin; Heme; Liver; Rats | 1981 |
Cycle GMP binding proteins of rat heart: identification using endogenous and exogenous cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Cyclic GMP; Filtration; Intracellular Signaling Peptides and Proteins; Myocardium; Rats | 1981 |
Role of cyclic nucleotides in the inhibition of growth-hormone secretion by somatostatin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cattle; Cholera Toxin; Cyclic AMP; Cyclic GMP; Female; Growth Hormone; Male; Pituitary Gland, Anterior; Somatostatin | 1981 |
A comparison of cyclic guanosine 3':5'-monophosphate and muscarinic excitatory responses in the superior cervical ganglion of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Atropine; Bethanechol Compounds; Chlorisondamine; Cyclic GMP; Electric Stimulation; Ganglia, Sympathetic; In Vitro Techniques; Male; Rats; Receptors, Cholinergic; Receptors, Muscarinic | 1981 |
Cyclic nucleotide metabolism in rat colonic epithelial cells with different proliferative activities.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cell Division; Colon; Cyclic AMP; Cyclic GMP; DNA; Epithelium; Female; Kinetics; Prostaglandins E; Protein Kinases; Rats; Vasoactive Intestinal Peptide | 1981 |
Evidence against a role of cyclic nucleotides in the regulation of anaphylactic histamine release in isolated rat mast cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aza Compounds; Cyclic AMP; Cyclic GMP; Histamine Release; Male; Mast Cells; Purinones; Rats; Rats, Inbred Strains; Theophylline | 1981 |
Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carboxy-Lyases; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Mice; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate; Theophylline; Time Factors | 1981 |
Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on the biochemical processes linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Cocarcinogenesis; Cyclic AMP; Cyclic GMP; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Theophylline | 1981 |
[Interrelationship between calcium and cyclic nucleotides in the functioning of retinal rods].
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic GMP; Drug Interactions; Male; Membrane Potentials; Papaverine; Photoreceptor Cells; Rana temporaria | 1981 |
Rapid increase in guanosine 3',5'-cyclic-monophosphate interferon treated mouse leukemia L1210 cells: relationship to the development of the antiviral state and inhibition of cell multiplication.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Division; Cyclic AMP; Cyclic GMP; Indomethacin; Interferons; Kinetics; Leukemia L1210; Mice; Tetradecanoylphorbol Acetate; Vesicular stomatitis Indiana virus; Virus Replication | 1981 |
Prostaglandin E2-histamine in interactions on cAMP, cGMP, and acid production in isolated fundic glands.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Biological Transport; Cyclic AMP; Cyclic GMP; Dinoprostone; Gastric Fundus; Gastric Juice; Histamine; Kinetics; Prostaglandins E | 1982 |
Independent mechanisms for bradykinin-mediated prostaglandin E2 and cyclic GMP syntheses in rabbit renal inner medulla slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Calcium; Cyclic GMP; Dinoprostone; In Vitro Techniques; Kidney Medulla; Prostaglandins E; Rabbits; Time Factors | 1982 |
Paradoxical stimulation by 1-methyl-3-isobutylxanthine of rat liver cyclic AMP phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Liver; Rats; Theophylline | 1982 |
Secretion of 3H-acetylcholine from guinea-pig ileum myenteric plexus is enhanced by 8-Br adenosine 3', 5'-cyclic monophosphate but not changed by 8-Br guanosine 3', 5'-cyclic monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Atropine; Cyclic AMP; Cyclic GMP; Electric Stimulation; Guinea Pigs; Ileum; Receptors, Cholinergic | 1982 |
Does cyclic GMP mediate amylase release from mouse parotid acini?
Topics: 1-Methyl-3-isobutylxanthine; Amylases; Animals; Azides; Bucladesine; Carbachol; Cyclic GMP; Hydroxylamines; Mice; Nitroprusside; Parotid Gland; Sodium Azide | 1982 |
cGMP-dependent protein kinase decreases calcium sensitivity of skinned cardiac fibers.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calmodulin; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Molecular Weight; Myocardial Contraction; Protein Kinases; Stimulation, Chemical; Swine | 1982 |
The effect of isobutylmethylxanthine on the photoresponse and phosphorylation of phosphatidylinositol in octopus retina.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Cyclic GMP; Darkness; Kinetics; Light; Octopodiformes; Phosphatidylinositols; Phosphorylation; Photic Stimulation; Photoreceptor Cells; Retina; Theophylline | 1983 |
Cyclic GMP efflux from liver slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Calcium; Cyclic GMP; In Vitro Techniques; Iodoacetamide; Kinetics; Liver; Male; Methylnitronitrosoguanidine; Probenecid; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Regulation of abalone sperm cyclic AMP concentrations and the acrosome reaction by calcium and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; Acrosome; Animals; Calcium; Cyclic GMP; Male; Mollusca; Sea Urchins; Spermatozoa; Theophylline; Xanthines | 1983 |
Effects of cyclic nucleotides on lipid biosynthesis in mouse mammary gland explants.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Animals; Bucladesine; Cyclic GMP; Dibutyryl Cyclic GMP; Female; Lipids; Mammary Glands, Animal; Mice; Pregnancy; Prolactin | 1983 |
On the relationship between autoinhibition of norepinephrine release and cyclic GMP metabolism in rat pineal glands.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bethanechol Compounds; Clonidine; Cyclic GMP; In Vitro Techniques; Male; Nitroprusside; Norepinephrine; Pineal Gland; Potassium; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1983 |
Effects of calcium and guanosine-3',5'-cyclic-monophosphoric acid on receptor potentials of toad rods.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bufo marinus; Calcium; Cyclic GMP; In Vitro Techniques; Iontophoresis; Kinetics; Membrane Potentials; Photic Stimulation; Photometry; Photoreceptor Cells; Rod Cell Outer Segment | 1983 |
Evidence against a role for guanosine 3',5'-cyclic monophosphate in rat submandibular salivary gland potassium release.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Norepinephrine; Parasympathomimetics; Potassium; Rats; Rats, Inbred Strains; Submandibular Gland; Sympathomimetics | 1983 |
Effect of guanine derivatives on lordosis behavior in estrogen primed rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Castration; Cyclic GMP; Estradiol; Female; Guanine; Guanosine; Guanosine Diphosphate; Guanosine Monophosphate; Rats; Rats, Inbred Strains; Sexual Behavior, Animal | 1983 |
Cyclic nucleotide responses and radiation-induced mitotic delay in Physarum polycephalum.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Caffeine; Cobalt Radioisotopes; Cyclic AMP; Cyclic GMP; Gamma Rays; Mitosis; Phosphodiesterase Inhibitors; Physarum; Theophylline; Time Factors | 1984 |
A modulatory octopaminergic neurone increases cyclic nucleotide levels in locust skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Amines; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Electric Stimulation; Female; Grasshoppers; Male; Muscles; Neuromuscular Junction; Octopamine; Stereoisomerism; Stimulation, Chemical | 1984 |
Cyclic GMP binding and phosphodiesterase: implication for platelet function.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine Diphosphate; Blood Platelets; Carrier Proteins; Cyclic GMP; Dipyridamole; Humans; Intracellular Signaling Peptides and Proteins; Nitroprusside; Platelet Aggregation; Receptors, Cyclic AMP | 1984 |
The effect of cyclic nucleotides and icosanoids on Na+ and K+ transport in human red cells.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport, Active; Bumetanide; Cyclic AMP; Cyclic GMP; Erythrocytes; Humans; Kinetics; Ouabain; Potassium; Prostaglandins; Sodium; Sodium-Potassium-Exchanging ATPase | 1983 |
Cyclic nucleotide distribution in identified layers of suprafused rabbit retinas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic AMP; Cyclic GMP; Dark Adaptation; Egtazic Acid; Freezing; Lighting; Methods; Nucleotides, Cyclic; Rabbits; Retina | 1984 |
Relationship between cycles in level of serotonin N-acetyltransferase activity and cyclic GMP content of cultured chick pineal glands.
Topics: 1-Methyl-3-isobutylxanthine; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Calcium Chloride; Chickens; Circadian Rhythm; Cyclic GMP; Darkness; Egtazic Acid; Etazolate; Folic Acid; Hypoxanthine; Hypoxanthines; Light; Pineal Gland; Theophylline | 1984 |
Relaxation of Mytilus catch muscle by 8-bromo-cyclic GMP and related compounds.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Bivalvia; Cyclic GMP; Egtazic Acid; Electric Stimulation; In Vitro Techniques; Mersalyl; Muscle Contraction; Muscle Relaxation; Potassium Chloride; Serotonin | 1984 |
Pharmacological control of ciliary activity in the young sea urchin larva. Studies on the role of Ca2+ and cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biogenic Amines; Bucladesine; Calcium; Cilia; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Larva; Phosphodiesterase Inhibitors; Potassium; Sea Urchins | 1984 |
Cyclic nucleotide-dependent enzyme secretion in the rat lacrimal gland.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Carbachol; Cardiotonic Agents; Colforsin; Cyclic GMP; Diterpenes; In Vitro Techniques; Isoenzymes; Lacrimal Apparatus; Male; Peroxidase; Peroxidases; Rats; Rats, Inbred Strains; Stimulation, Chemical; Time Factors | 1984 |
Adenosine and adenosine analogues stimulate adenosine cyclic 3', 5'-monophosphate-dependent chloride secretion in the mammalian ileum.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Biological Transport; Chlorides; Cyclic AMP; Cyclic GMP; Ileum; Kinetics; Male; Phenylisopropyladenosine; Rabbits; Theophylline | 1984 |
3',5'-cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenylyl Cyclases; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic GMP; Diterpenes; Fluorides; Horseshoe Crabs; In Vitro Techniques; Light; Photoreceptor Cells; Time Factors; Vanadates; Vanadium | 1984 |
A novel membrane sodium current induced by injection of cyclic nucleotides into gastropod neurones.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Aplysia; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Membrane Potentials; Mollusca; Neurons; Quaternary Ammonium Compounds; Ribonucleotides; Sodium; Tetrodotoxin | 1984 |
Intracellular pH changes induced by injection of cyclic nucleotides into gastropod neurones.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Cytoplasm; Dose-Response Relationship, Drug; Guanosine Monophosphate; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Mollusca; Neurons; Time Factors | 1984 |
Forskolin perturbs cGMP as well as cAMP levels in human thyroid cells.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Diterpenes; Humans; Phosphodiesterase Inhibitors; Thyroid Gland; Thyrotropin | 1984 |
Cyclic GMP relaxes the internal anal sphincter in Hirschsprung's disease.
Topics: 1-Methyl-3-isobutylxanthine; Anal Canal; Colon; Cyclic AMP; Cyclic GMP; Ganglia; Hirschsprung Disease; Humans; Isometric Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Phosphodiesterase Inhibitors | 1995 |
A cellular mechanism for nitric oxide-mediated cholinergic control of mammalian heart rate.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Arginine; Carbachol; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Enzyme Inhibitors; GTP-Binding Proteins; Guanylate Cyclase; Heart Rate; Isoproterenol; Methylene Blue; Molsidomine; Muscarinic Agonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Aggregation Inhibitors; Rabbits; Receptors, Cholinergic; Receptors, Muscarinic; Sinoatrial Node; Thionucleotides | 1995 |
A selective agonist of endothelin type B receptor, IRL 1620, stimulates cyclic GMP increase via nitric oxide formation in rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Arginine; Binding Sites; Calcium; Cyclic GMP; Cytosol; Drug Interactions; Endothelins; Endothelium, Vascular; Kinetics; Male; Membranes; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; omega-N-Methylarginine; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Wistar; Receptors, Endothelin; Stimulation, Chemical; Time Factors | 1993 |
Immunohistochemical localization of 3',5'-cyclic guanosine monophosphate in the canine proximal colon: responses to nitric oxide and electrical stimulation of enteric inhibitory neurons.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Colon; Cyclic GMP; Dogs; Electric Stimulation; Enteric Nervous System; Female; Ganglia, Autonomic; Male; Nitric Oxide; Nitroprusside; Purinones; Second Messenger Systems | 1993 |
Dexamethasone sensitizes soluble guanylate cyclase in the rat renal glomeruli.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Cytosol; Desoxycorticosterone; Dexamethasone; Guanylate Cyclase; Kidney Glomerulus; Kinetics; L-Lactate Dehydrogenase; Male; Nitroprusside; Rats; Rats, Wistar; Reference Values | 1993 |
Histamine H3-receptor-induced inhibition of duodenal cholinergic transmission is independent of intracellular cyclic AMP and GMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Clonidine; Colforsin; Cyclic AMP; Cyclic GMP; Duodenum; Guinea Pigs; Histamine Agonists; In Vitro Techniques; Male; Methylhistamines; Parasympathetic Nervous System; Receptors, Histamine H3; Signal Transduction; Synaptic Transmission | 1993 |
Synthesis and vectorial export of cGMP in airway epithelium: expression of soluble and CNP-specific guanylate cyclases.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Animals; Atrial Natriuretic Factor; Cell Line; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Epithelium; Female; Gene Expression; Guanylate Cyclase; Humans; Isoenzymes; Kinetics; Lung; Male; Middle Aged; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Rats; Time Factors | 1993 |
Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkaloids; Amino Acid Oxidoreductases; Animals; Arginine; Calcimycin; Carbachol; Cyclic GMP; Diabetes Mellitus, Experimental; Female; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoquinolines; Kidney Glomerulus; Kinetics; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phosphates; Phosphorylation; Piperazines; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Staurosporine; Thromboxane A2 | 1994 |
Laminar flow stimulates ATP- and shear stress-dependent nitric oxide production in cultured bovine endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Arginine; Calcium; Cattle; Cells, Cultured; Cyclic GMP; Egtazic Acid; Endothelium, Vascular; Fetus; Kinetics; Nitric Oxide; omega-N-Methylarginine; Stress, Mechanical | 1994 |
Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Base Sequence; Cells, Cultured; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Cysteine; DNA Primers; Electric Conductivity; Gene Expression; In Situ Hybridization; Ion Channels; Membrane Potentials; Models, Neurological; Molecular Sequence Data; Nitric Oxide; Nitroprusside; Polymerase Chain Reaction; Rats; Rats, Wistar; Retinal Ganglion Cells; Retinal Rod Photoreceptor Cells; S-Nitrosothiols; Transcription, Genetic | 1994 |
External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment.
Topics: 1-Methyl-3-isobutylxanthine; Aedes; Animals; Brugia; Calcimycin; Cyclic AMP; Cyclic GMP; Dipetalonema; Gallic Acid; Hydrogen-Ion Concentration; Larva; Mammals; Nematoda; Nicardipine; Nippostrongylus; Nitroprusside; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Trichinella | 1993 |
Organic nitrates and compounds that increase intraplatelet cyclic guanosine monophosphate (cGMP) levels enhance the antiaggregating effects of the stable prostacyclin analogue iloprost.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adult; Arginine; Blood Platelets; Collagen; Cyclic AMP; Cyclic GMP; Drug Synergism; Endothelium, Vascular; Epinephrine; Humans; Iloprost; Intracellular Fluid; Male; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 4; Second Messenger Systems | 1993 |
Monitoring of cyclic GMP during cerebellar microdialysis in freely-moving rats as an index of nitric oxide synthase activity.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Cerebellum; Cyclic GMP; Extracellular Space; Male; Microdialysis; Monitoring, Physiologic; Motor Activity; N-Methylaspartate; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Binding of atrial and brain natriuretic peptides to cultured mouse astrocytes from different brain regions and effect on cyclic GMP production.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Atrial Natriuretic Factor; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Cyclic GMP; Hypothalamus; Mice; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Organ Specificity; Receptors, Atrial Natriuretic Factor; Signal Transduction | 1993 |
Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Calmodulin; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Egtazic Acid; Endothelin Receptor Antagonists; Endothelins; Glomerular Mesangium; Guanylate Cyclase; Hemoglobins; In Vitro Techniques; Kidney Glomerulus; Kinetics; Male; Methylene Blue; Nicardipine; Nitric Oxide; omega-N-Methylarginine; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Sulfonamides | 1994 |
Induction of nitric oxide release by interferon-gamma inhibits vasodilation and cyclic GMP increase in bovine isolated mesenteric arteries.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Cattle; Cyclic GMP; In Vitro Techniques; Interferon-gamma; Mesenteric Arteries; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Vasodilation | 1994 |
Nucleotide inhibitors and activators of retinal guanylyl cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Cattle; Cyclic GMP; Enzyme Activation; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Tetraphosphate; Guanosine Triphosphate; Guanylate Cyclase; Nucleotides; Retina; Rod Cell Outer Segment | 1994 |
Smooth muscle cell responsiveness to nitrovasodilators in hypertensive and normotensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Base Sequence; Blotting, Northern; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Guanylate Cyclase; Hypertension; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroprusside; Oligonucleotide Probes; omega-N-Methylarginine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Vasodilation | 1994 |
Corticotropin-releasing factor stimulates Ca2+ influx in cultured rat astrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Animals, Newborn; Astrocytes; Calcium; Cells, Cultured; Cerebral Cortex; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic GMP; Kinetics; Nifedipine; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Relaxant mechanisms of cyclic AMP-increasing agents in porcine coronary artery.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic beta-Agonists; Animals; Calcium; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; Ethanolamines; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Ryanodine; Swine; Thromboxane A2; Vasodilator Agents | 1994 |
Cyclic AMP enhancing drugs modulate eicosanoid release from human alveolar macrophages.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Albuterol; Bronchoalveolar Lavage Fluid; Cyclic AMP; Cyclic GMP; Dinoprostone; Female; Humans; Leukotriene B4; Lung; Lung Diseases, Obstructive; Macrophages, Alveolar; Male; Middle Aged; Nitroprusside; Smoking | 1994 |
Forskolin and 3-isobutyl-1-methylxanthine increase basal and sodium nitroprusside-elevated cyclic GMP levels in adult guinea-pig cerebellar slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cerebellum; Colforsin; Cyclic AMP; Cyclic GMP; Ferrocyanides; Guinea Pigs; In Vitro Techniques; Nitric Oxide; Nitroprusside | 1994 |
Cross talk among cyclic AMP, cyclic GMP, and Ca(2+)-dependent intracellular signalling mechanisms in brain capillary endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Capillaries; Cells, Cultured; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cyclic GMP; Endothelins; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Intracellular Membranes; Isoproterenol; Rats; Receptors, Endothelin; Signal Transduction | 1994 |
Enhancement of cytosolic calcium, prostacyclin and nitric oxide by bradykinin and the ACE inhibitor ramiprilat in porcine brain capillary endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 6-Ketoprostaglandin F1 alpha; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Bradykinin; Calcium; Capillaries; Cells, Cultured; Cerebrovascular Circulation; Cyclic GMP; Cytosol; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; Fura-2; Kinetics; Nitric Oxide; Nitroarginine; Ramipril; Swine | 1994 |
cGMP acts within cerebellar Purkinje cells to produce long term depression via mechanisms involving PKC and PKG.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Oxidoreductases; Animals; Arginine; Cyclic GMP; Electrophysiology; Enzyme Activation; Nitric Oxide Synthase; Nitroarginine; Potassium Chloride; Protein Kinase C; Purkinje Cells; Rats | 1994 |
S35b, a new phenylsulfonylfuroxan compound, inhibits thrombin-induced synthesis of platelet-activating factor and prostacyclin in human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetyltransferases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Humans; Iloprost; Oxadiazoles; Platelet Activating Factor; Platelet Aggregation Inhibitors; Thrombin; Umbilical Veins | 1993 |
CHF 2206, a new potent vasodilating and antiaggregating drug as potential nitric oxide donor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Blood Platelets; Cyclic GMP; Endothelium, Vascular; Humans; In Vitro Techniques; Male; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Oxadiazoles; Oxyhemoglobins; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Vasodilator Agents | 1994 |
Induction of photoresponse by the hydrolysis of polyphosphoinositides in the Hermissenda type B photoreceptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Lithium Chloride; Models, Biological; Neomycin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Photoreceptor Cells, Invertebrate; Platelet Activating Factor; Pyrimidinones; Snails; Spermine; Thiazoles; Thionucleotides; Type C Phospholipases | 1994 |
Insulin increases guanosine-3',5'-cyclic monophosphate in human platelets. A mechanism involved in the insulin anti-aggregating effect.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adult; Amino Acid Oxidoreductases; Arginine; Blood Platelets; Collagen; Cyclic GMP; Female; Genistein; Guanylate Cyclase; Humans; Insulin; Isoflavones; Male; Methylene Blue; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein-Tyrosine Kinases; Radioimmunoassay; Recombinant Proteins | 1994 |
Oxygen modulates nitric oxide production selectively in fetal pulmonary endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Bradykinin; Calcimycin; Cells, Cultured; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Female; Guanylate Cyclase; Humans; Hypoxia; Infant, Newborn; Lung; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxygen; Persistent Fetal Circulation Syndrome; Pregnancy; Pulmonary Artery; Sheep | 1994 |
Involvement of cAMP and cGMP in the mode of action of molt-inhibiting hormone (MIH) a neuropeptide which inhibits steroidogenesis in a crab.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brachyura; Bucladesine; Colforsin; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Ecdysone; Invertebrate Hormones | 1994 |
Different pial arteriolar responses to acetylcholine in the newborn and juvenile pig.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Aging; Animals; Animals, Newborn; Arginine; Arterioles; Calcimycin; Cerebrovascular Circulation; Cyclic GMP; Female; Male; Nitroarginine; Nitroprusside; Pia Mater; Swine | 1994 |
Potentiation by forskolin of both SNP- and ANP-stimulated cyclic GMP accumulation in porcine isolated palmar lateral vein.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Colforsin; Cyclic GMP; Drug Synergism; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroprusside; Pyrrolidinones; Rolipram; Veins | 1994 |
Angiotensin AT2 receptor mediated inhibition of particulate guanylate cyclase: a link with protein tyrosine phosphatase stimulation?
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Aorta; Arsenicals; Atrial Natriuretic Factor; Cell Membrane; Cells, Cultured; Cyclic GMP; GTP-Binding Proteins; Guanylate Cyclase; Muscle, Smooth, Vascular; Oligopeptides; PC12 Cells; Protein Tyrosine Phosphatases; Rats; Receptors, Angiotensin; Vanadates | 1994 |
Endothelin secretion is regulated by cyclic AMP and phosphatase 2A in endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Endothelins; Endothelium, Vascular; Ethers, Cyclic; Humans; In Vitro Techniques; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 2 | 1994 |
Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Antibodies, Monoclonal; Biological Assay; Bucladesine; Cells, Cultured; Crosses, Genetic; Cyclic AMP; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Interleukin-10; Interleukin-6; Kinetics; Lactates; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide; Prostaglandins E; Shock, Septic; Tumor Necrosis Factor-alpha | 1994 |
In vitro endotoxin exposure induces contractile dysfunction in adult rat cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Cell Survival; Cells, Cultured; Citrulline; Cyclic GMP; Dactinomycin; Electric Stimulation; Endotoxins; Heart; Kinetics; Male; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Nitroprusside; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Interactions of atrial natriuretic peptide with A7r5 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Bacitracin; Binding, Competitive; Cell Line; Cyclic GMP; Iodine Radioisotopes; Kinetics; Muscle, Smooth, Vascular; Rats; Receptors, Atrial Natriuretic Factor; Time Factors | 1994 |
Phorbol ester activation of protein kinase C inhibits CNP-stimulated cyclic GMP production in the mouse AtT-20 pituitary tumour cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cell Line; Colforsin; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Mice; Natriuretic Peptide, C-Type; Pituitary Neoplasms; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
YC-1, a novel activator of platelet guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alprostadil; Animals; Bleeding Time; Blood Platelets; Calcium; Colforsin; Collagen; Cyclic AMP; Cyclic GMP; Drug Interactions; Enzyme Activation; Guanylate Cyclase; Imidazoles; Indazoles; Indomethacin; Methemoglobin; Mice; Molecular Structure; Nitroprusside; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Prostaglandin D2; Rabbits; Superoxide Dismutase; Thromboxane A2 | 1994 |
Atrial natriuretic peptide reduces cyclic AMP by activating cyclic GMP-stimulated phosphodiesterase in vascular endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclases; Animals; Aorta; Atrial Natriuretic Factor; Cattle; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Isoenzymes; Isoproterenol; Isoquinolines; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Tetrahydroisoquinolines | 1994 |
Neointima formation is promoted by surgical preparation and inhibited by cyclic nucleotides in human saphenous vein organ cultures.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Adult; Aged; Cell Division; Cyclic GMP; Female; Humans; Male; Middle Aged; Muscle, Smooth, Vascular; Organ Culture Techniques; Saphenous Vein; Tunica Intima | 1995 |
Effects of cyclic nucleotide phosphodiesterase IV inhibitor, Ro20,1724, on pancreatic exocrine secretion in dog.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amrinone; Analysis of Variance; Animals; Bicarbonates; Cyclic AMP; Cyclic GMP; Dogs; Drug Interactions; Female; Injections, Intra-Arterial; Male; Pancreatic Juice; Phosphodiesterase Inhibitors; Proteins; Secretin; Sincalide; Trifluoperazine | 1994 |
Cyclic AMP stimulates K+ channel activity in mesophyll cells of Vicia faba L.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Brain; Bucladesine; Cattle; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electric Stimulation; Fabaceae; Guanosine Monophosphate; Intercellular Signaling Peptides and Proteins; Kinetics; Macromolecular Substances; Membrane Potentials; Organothiophosphorus Compounds; Peptides; Plants, Medicinal; Potassium Channels | 1994 |
Desulfated hirugen (hirudin 54-65) induces endothelium-dependent relaxation of porcine pulmonary arteries.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Arginine; Atropine; Bradykinin; Calcium; Captopril; Cyclic GMP; Dinoprost; Endothelium, Vascular; Hirudins; Histamine; Indomethacin; Ketanserin; Methiothepin; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Peptide Fragments; Phentolamine; Pulmonary Artery; Swine; Vasodilation | 1994 |
Impaired cyclic nucleotide-dependent vasorelaxation in human umbilical artery smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carotid Arteries; Cattle; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; In Vitro Techniques; Isometric Contraction; Kinetics; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Phosphorylation; Serotonin; Umbilical Arteries | 1995 |
Voltage-activated K channel in luminal membrane of marginal cells of stria vascularis dissected from guinea pig.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cyclic GMP; Cytoplasm; Electric Stimulation; Electrophysiology; Gluconates; Guinea Pigs; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Sodium Chloride; Stria Vascularis | 1994 |
Tyrosine kinase inhibitors enhance cGMP production in rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Arginine; Catechols; Cyclic AMP; Cyclic GMP; Genistein; Hydroquinones; Isoflavones; Isoproterenol; Male; Nitric Oxide Synthase; Nitriles; Norepinephrine; omega-N-Methylarginine; Pineal Gland; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Tyrphostins | 1995 |
Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Arginine; Colforsin; Cyclic AMP; Cyclic GMP; Female; Glucose; Hydrogen Peroxide; Hydroxylamine; Hydroxylamines; In Vitro Techniques; Insulin; Islets of Langerhans; Mice; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxides; Reactive Oxygen Species; tert-Butylhydroperoxide; Vasodilator Agents | 1995 |
Nitric oxide synthesis in rat mesangial cells induced by cytokines.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Arginine; Cells, Cultured; Chemotactic Factors; Cyclic GMP; Cycloheximide; Cytokines; Dactinomycin; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression; Glomerular Mesangium; Interleukin-1; Interleukin-6; Interleukin-8; Kinetics; Male; Monocyte Chemoattractant Proteins; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Transforming Growth Factor beta | 1994 |
Phosphatase inhibitors potentiate adrenergic-stimulated cAMP and cGMP production in rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antifungal Agents; Cyclic AMP; Cyclic GMP; Drug Synergism; Ethers, Cyclic; Isoproterenol; Kinetics; Male; Marine Toxins; Norepinephrine; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pineal Gland; Protein Phosphatase 2; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds | 1995 |
Cyclic GMP diffusion coefficient in rod photoreceptor outer segments.
Topics: 1-Methyl-3-isobutylxanthine; Ambystoma; Animals; Biophysical Phenomena; Biophysics; Cyclic GMP; Diffusion; Electrochemistry; Hydrolysis; In Vitro Techniques; Ion Channels; Ion Transport; Kinetics; Membrane Potentials; Models, Biological; Photochemistry; Rana catesbeiana; Rod Cell Outer Segment | 1995 |
Secretion of cyclic GMP by cultured epithelial and fibroblast cell lines in response to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cyclic AMP; Cyclic GMP; Epithelium; Fibroblasts; Guanylate Cyclase; Molsidomine; Nitric Oxide; Oxyhemoglobins; Probenecid; Swine | 1995 |
Change in vascular cAMP and cGMP contents in portal hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Colforsin; Cyclic AMP; Cyclic GMP; Hemodynamics; Hypertension, Portal; Rats; Rats, Sprague-Dawley | 1995 |
Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Electric Stimulation; Gastric Fundus; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Rats; Rats, Wistar; Signal Transduction; Vasoactive Intestinal Peptide | 1995 |
Nitric oxide induces an increased Na+ conductance in identified neurons of Aplysia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Cell Membrane; Cyclic GMP; Electric Conductivity; Ganglia, Invertebrate; Hydroxylamine; Hydroxylamines; Ions; Methylene Blue; Microinjections; Neurons; Nitric Oxide; Nitroprusside; Sodium | 1995 |
Role of cyclic nucleotides and nitric oxide in blood mononuclear cell IgE production stimulated by IL-4.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Arginine; B-Lymphocytes; Cholera Toxin; Cyclic AMP; Cyclic GMP; Drug Synergism; Epinephrine; Gene Expression Regulation; Humans; Immunoglobulin E; Interleukin-4; Leukocytes, Mononuclear; Molsidomine; Nitric Oxide; omega-N-Methylarginine; Receptors, IgE; Recombinant Fusion Proteins | 1995 |
Autonomic regulation of cardiac chloride current.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Autonomic Agents; Chloride Channels; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Isoproterenol | 1994 |
Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Arginine; Cells, Cultured; Cyclic GMP; Dexamethasone; Enzyme Induction; Gene Expression; Humans; Interferon-gamma; Interleukin-1; Interleukins; Isoenzymes; Lipopolysaccharides; Liver; Mice; Nitrates; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Rats; Recombinant Proteins; RNA, Messenger; Species Specificity; Tumor Necrosis Factor-alpha | 1995 |
Cyclic GMP-mediated inhibition of L-type Ca2+ channel activity by human natriuretic peptide in rabbit heart cells.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Calcium Channel Blockers; Calcium Channels; Cyclic GMP; Heart; Heart Ventricles; Humans; Myocardium; Patch-Clamp Techniques; Rabbits | 1995 |
Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Female; Gastric Fundus; In Vitro Techniques; Isoenzymes; Male; Muscle Relaxation; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrrolidinones; Rolipram; Vasoactive Intestinal Peptide | 1995 |
Ca2+ modulation of the cGMP-gated channel of bullfrog retinal rod photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Ion Channels; Membrane Potentials; Rana catesbeiana; Retinal Rod Photoreceptor Cells; Time Factors | 1995 |
IBMX induces calcium release from intracellular stores in rat sensory neurones.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Biological Transport; Bucladesine; Caffeine; Calcium; Cell Compartmentation; Colforsin; Cyclic GMP; Dibutyryl Cyclic GMP; Endoplasmic Reticulum; Ganglia, Spinal; Neurons, Afferent; Rats; Theophylline | 1995 |
Cyclic guanosine 3',5'-monophosphate mediates 3-morpholinosydnonimine-induced inhibition of human natural killer cells.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Cyclic GMP; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Killer Cells, Natural; Methylene Blue; Molsidomine; Nitric Oxide; Tumor Cells, Cultured | 1995 |
Two novel rat guanylin molecules, guanylin-94 and guanylin-16, do not increase cyclic GMP production in T84 cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Cell Line; Chromatography, Gel; Chromatography, High Pressure Liquid; Colon; Cyclic GMP; Gastrointestinal Hormones; Ileum; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Kinetics; Male; Mass Spectrometry; Molecular Sequence Data; Natriuretic Peptides; Peptides; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley | 1995 |
Differential antimitogenic effectiveness of atrial natriuretic peptides in primary versus subcultured rat aortic smooth muscle cells: relationship to expression of ANF-C receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Atrial Natriuretic Factor; Binding, Competitive; Cell Division; Cells, Cultured; Cyclic GMP; Male; Muscle, Smooth, Vascular; Nitric Oxide; Protease Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor | 1993 |
Cytotoxicity of activated rat macrophages against syngeneic islet cells is arginine-dependent, correlates with citrulline and nitrite concentrations and is identical to lysis by the nitric oxide donor nitroprusside.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Cells, Cultured; Citrulline; Cyclic GMP; Female; Islets of Langerhans; Kinetics; Macrophage Activation; Macrophages; Male; Nitric Oxide; Nitrites; Nitroprusside; omega-N-Methylarginine; Rats; Rats, Wistar; Thionucleotides | 1993 |
Interleukin-1 beta effects on cyclic GMP and cyclic AMP in cultured rat islets of Langerhans-arginine-dependence and relationship to insulin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Antihypertensive Agents; Arginine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Kinetics; Molsidomine; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley | 1993 |
Initial biochemical and functional characterization of cyclic nucleotide phosphodiesterase isozymes in canine colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Colforsin; Colon; Cyclic AMP; Cyclic GMP; Dogs; Isoenzymes; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rolipram | 1993 |
Staurosporine-independent platelet aggregation induced by the calcium ionophore ionomycin is inhibited by prostacyclin and sodium nitroprusside and stimulated by adrenaline.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Bucladesine; Calcium; Cyclic GMP; Epinephrine; Epoprostenol; Humans; Ionomycin; Nitroprusside; Phosphoproteins; Platelet Aggregation; Protein Kinase C; Staurosporine; Yohimbine | 1993 |
Cyclic guanosine monophosphate production in the pituitary: stimulation by C-type natriuretic peptide and inhibition by gonadotropin-releasing hormone in alpha T3-1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcimycin; Cell Line; Cyclic GMP; Female; Gonadotropin-Releasing Hormone; Inositol Phosphates; Luteinizing Hormone; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Pituitary Gland; Protein Kinase C; Rats | 1993 |
Atrial natriuretic peptide inhibits growth of hepatoblastoma (HEP G2) cells by means of activation of clearance receptors.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Carcinoma, Hepatocellular; Cell Division; Cyclic AMP; Cyclic GMP; DNA Replication; Epidermal Growth Factor; Kinetics; Liver Neoplasms; Peptide Fragments; Receptors, Atrial Natriuretic Factor; RNA, Messenger; RNA, Neoplasm; Thymidine; Tritium; Tumor Cells, Cultured | 1993 |
IL1 and TNF alpha induce cGMP formation in C6 astrocytoma cells via the nitridergic pathway.
Topics: 1-Methyl-3-isobutylxanthine; Arginine; Astrocytoma; Cyclic GMP; Interleukin-1; Nitrites; omega-N-Methylarginine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
A dramatic pH-dependent alteration in ANP receptor density: a note for using cultured cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Carotid Arteries; Cattle; Cells, Cultured; Culture Media; Culture Techniques; Cyclic GMP; Endothelium, Vascular; Hydrogen-Ion Concentration; Kinetics; Receptors, Atrial Natriuretic Factor | 1993 |
Nitric oxide-generating system as an autocrine mechanism in human polymorphonuclear leucocytes.
Topics: 1-Methyl-3-isobutylxanthine; Arginine; Biological Transport; Citrulline; Cyclic GMP; Endothelins; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Nitroprusside; omega-N-Methylarginine | 1993 |
Photosensory transduction in ciliates. IV. Modulation of the photomovement response of Blepharisma japonicum by cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Cell Movement; Cholera Toxin; Ciliophora; Cyclic GMP; Dibutyryl Cyclic GMP; Light; Pertussis Toxin; Signal Transduction; Virulence Factors, Bordetella | 1993 |
Inhibitory effect of NZ-105, a 1,4-dihydropyridine derivative, on cyclic nucleotide phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Calcium Channel Blockers; Cattle; Cyclic AMP; Cyclic GMP; Dihydropyridines; In Vitro Techniques; Intracellular Fluid; Male; Myocardium; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rabbits | 1993 |
Reduction of nitric oxide producing activity associated with in vitro aging in cultured human umbilical vein endothelial cell.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Arginine; Cell Division; Cell Line; Cells, Cultured; Cellular Senescence; Cerebellum; Cyclic GMP; Endothelium, Vascular; Epithelium; Humans; Kidney; Kinetics; Mice; Mice, Inbred Strains; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Tumor Cells, Cultured; Umbilical Veins | 1993 |
HS-142-1 inhibits testosterone production and guanosine-3':5'-cyclic monophosphate accumulation stimulated by atrial natriuretic peptide in isolated mouse Leydig cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Chorionic Gonadotropin; Colforsin; Cyclic GMP; Gene Expression Regulation; Leydig Cells; Male; Mice; Polysaccharides; Rats; Receptors, Atrial Natriuretic Factor; Second Messenger Systems; Testosterone | 1993 |
Cyclic nucleotide regulation of teleost rod photoreceptor inner segment length.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Actins; Animals; Cyclic AMP; Cyclic GMP; Cytoskeleton; Darkness; Ethers, Cyclic; In Vitro Techniques; Isoquinolines; Light; Okadaic Acid; Peptide Chain Elongation, Translational; Perciformes; Phosphoprotein Phosphatases; Photoreceptor Cells; Piperazines; Protein Kinase Inhibitors | 1993 |
Nitric oxide targets in the guinea-pig intestine identified by induction of cyclic GMP immunoreactivity.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Colon; Cyclic GMP; Dextrans; Fluorescein-5-isothiocyanate; Ganglia, Autonomic; Guinea Pigs; Ileum; Immunohistochemistry; Macrophages; Microscopy, Immunoelectron; Myenteric Plexus; NADPH Dehydrogenase; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Vasoactive Intestinal Peptide | 1993 |
Muscarinic agonists have no measurable effect on cGMP formation of rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Bethanechol; Bethanechol Compounds; Calcium; Carbachol; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Kinetics; Male; Nitroprusside; Norepinephrine; Parasympathomimetics; Pineal Gland; Rats; Rats, Sprague-Dawley; Theophylline | 1993 |
Selective modulation by cGMP of the K+ channel activated by speract.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Ammonium Chloride; Animals; Cyclic AMP; Cyclic GMP; Dimethyl Sulfoxide; Hydrogen-Ion Concentration; Kinetics; Male; Membrane Potentials; Oligopeptides; Papaverine; Potassium; Potassium Channels; Sea Urchins; Semen; Spermatozoa; Tetraethylammonium; Tetraethylammonium Compounds | 1993 |
Antagonism by NG-nitro-L-arginine of L-glutamate-induced neurotoxicity in cultured neonatal rat cortical neurons. Prolonged application enhances neuroprotective efficacy.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Animals, Newborn; Arginine; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Rats; Rats, Sprague-Dawley | 1993 |
Effects of PDE inhibitors and carbachol on the L-type Ca current in guinea pig ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Carbachol; Chloride Channels; Cyclic AMP; Cyclic GMP; Electric Conductivity; Guinea Pigs; Heart Ventricles; Myocardium; Papaverine; Parasympathomimetics; Phosphodiesterase Inhibitors | 1993 |
cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Kinetics; Lung; Macromolecular Substances; Nitroprusside; Rats; RNA, Messenger | 1993 |
Effects of phosphodiesterase inhibitors and forskolin on cyclic GMP-activated channels in intact isolated cells of the chick pineal gland.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chick Embryo; Chickens; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Ion Channel Gating; Ion Channels; Papaverine; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pineal Gland | 1995 |
Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Cells, Cultured; Culture Media; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; Guanylate Cyclase; Humans; Ion Transport; Molsidomine; Nitric Oxide; Ouabain; Penicillamine; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Probenecid; Prostaglandin D2; Prostaglandins; Prostaglandins A; Purinones; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase; Time Factors; Triazoles | 1995 |
Inhibition of cGMP breakdown promotes the induction of cerebellar long-term depression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cerebellum; Cyclic GMP; Dipyridamole; Long-Term Potentiation; Male; Phosphodiesterase Inhibitors; Purinones; Purkinje Cells; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
Protein kinase C modulates natriuretic peptide receptors in astroglial cultures from rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Animals, Newborn; Astrocytes; Atrial Natriuretic Factor; Binding Sites; Brain Stem; Cells, Cultured; Colforsin; Cyclic GMP; Down-Regulation; Enzyme Inhibitors; Hypothalamus; Kinetics; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Biological Transport; Bradykinin; Captopril; Colon; Cyclic GMP; Dihydrolipoamide Dehydrogenase; Dinoprostone; In Vitro Techniques; Intestinal Mucosa; Ions; Models, Biological; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Vasodilator Agents | 1996 |
cGMP stimulates bile acid-independent bile formation and biliary bicarbonate excretion.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Arginine Vasopressin; Bicarbonates; Bile; Bile Acids and Salts; Calcium; Cells, Cultured; Choline; Cyclic AMP; Cyclic GMP; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Liver; Male; Oxygen Consumption; Rats; Rats, Wistar; Taurocholic Acid; Thionucleotides; Ursodeoxycholic Acid | 1996 |
Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: inhibitory role mediated by cyclic GMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcium; Catecholamines; Cattle; Chromaffin Granules; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Natriuretic Peptide, C-Type; Nitric Oxide; Nitroprusside; Proteins | 1996 |
Caged compounds of hydrolysis-resistant analogues of cAMP and cGMP: synthesis and application to cyclic nucleotide-gated channels.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cattle; Cell Line; Cyclic AMP; Cyclic GMP; Humans; Indicators and Reagents; Ion Channel Gating; Ion Channels; Kidney; Kinetics; Magnetic Resonance Spectroscopy; Neurons, Afferent; Olfactory Pathways; Photolysis; Signal Transduction; Spectrophotometry; Stereoisomerism; Ultraviolet Rays | 1996 |
Cyclic nucleotide-induced termination of vitellogenin uptake by Hyalophora cecropia follicles.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Bucladesine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Drug Synergism; Enzyme Activation; Female; Isoquinolines; Moths; Nucleotides, Cyclic; Oviducts; Phosphodiesterase Inhibitors; Sulfonamides; Vitellogenins | 1996 |
Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Aorta; Blood Platelets; Cattle; Cell Division; Cell Movement; Cells, Cultured; Cyclic GMP; Female; Femoral Artery; Humans; In Vitro Techniques; Indium Radioisotopes; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroso Compounds; Platelet Adhesiveness; Rabbits; Rats; Serum Albumin, Bovine; Sulfhydryl Compounds; Tunica Intima | 1995 |
Inhibitory effects of natriuretic peptides on vasopressin neurons mediated through cGMP and cGMP-dependent protein kinase in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Electrophysiology; Enzyme Inhibitors; Isoquinolines; Male; Membrane Potentials; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Neurons; Phosphodiesterase Inhibitors; Phthalazines; Rats; Rats, Wistar; Second Messenger Systems; Supraoptic Nucleus; Vasopressins | 1993 |
Phosphodiesterase inhibitors correct resistance to natriuretic peptides in rats with Heymann Nephritis.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Atrial Natriuretic Factor; Cyclic GMP; Diuretics; Glomerular Filtration Rate; Glomerulonephritis; In Vitro Techniques; Kidney Glomerulus; Kidney Tubules, Collecting; Male; Natriuresis; Peptide Fragments; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor | 1996 |
PMA and ionomycin differently affect atrial natriuretic peptide stimulated cyclic GMP production in rat mesangial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Enzyme Activation; Glomerular Mesangium; Ionomycin; Ionophores; Male; Phosphodiesterase Inhibitors; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1996 |
Presence of functional type B natriuretic peptide receptor in human ocular cells.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Calcium; Carbachol; Cell Line, Transformed; Cells, Cultured; Ciliary Body; Cyclic GMP; Guanylate Cyclase; Humans; Intraocular Pressure; Kinetics; Muscle Contraction; Natriuretic Peptide, C-Type; Proteins; Receptors, Atrial Natriuretic Factor; Simian virus 40; Trabecular Meshwork | 1996 |
Intestinal secretory response to atrial natriuretic peptide during postnatal development in the rabbit.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Atrial Natriuretic Factor; Chlorides; Cyclic GMP; Electric Conductivity; Electric Stimulation; Ileum; Intestines; Rabbits | 1996 |
The involvement of the release of nitric oxide in the pharmacological activity of the new furoxan derivative CHF 2363.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1996 |
Effects of the 3',5'-phosphodiesterase inhibitors isobutylmethylxanthine and zaprinast on NO-mediated cGMP accumulation in the hippocampus slice preparation: an immunocytochemical study.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Hippocampus; Immunohistochemistry; Nitric Oxide; Organ Culture Techniques; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Inbred Strains | 1996 |
Effects of maturation on cyclic GMP metabolism in ovine carotid arteries.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Animals, Newborn; Carotid Arteries; Cyclic GMP; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sheep | 1996 |
Light-sensitive response in melanophores of Xenopus laevis: I. Spectral characteristics of melanophore response in isolated tail fin of Xenopus tadpole.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amphibians; Animals; Calcium; Calcium Channel Blockers; Cyclic CMP; Cyclic GMP; Enzyme Inhibitors; Gallic Acid; Ionophores; Light; Macrolides; Melanophores; Membrane Potentials; Ouabain; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Retinal Rod Photoreceptor Cells; Skin Pigmentation; Sodium-Potassium-Exchanging ATPase; Tail; Verapamil; Xenopus laevis | 1996 |
Potentiation of IPSCs by nitric oxide in immature rat sympathetic preganglionic neurones in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Fibers; Animals; Animals, Newborn; Autonomic Fibers, Preganglionic; Cyclic GMP; Electrophysiology; Enzyme Inhibitors; Hemoglobins; Membrane Potentials; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Synapses | 1996 |
Mechanisms contributing to renal resistance to atrial natriuretic peptide in rats with common bile-duct ligation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Blood Volume; Common Bile Duct; Cyclic GMP; Drug Resistance; Kidney; Ligation; Liver Diseases; Male; Natriuresis; Nervous System; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley | 1996 |
Evidence for inducible nitric oxide synthase in spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Cyclic GMP; Enzyme Induction; Guanidines; In Vitro Techniques; Isoenzymes; Lipopolysaccharides; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tumor Necrosis Factor-alpha | 1996 |
ANP-stimulated cGMP egression in renal principal cells: abrogation of polarity by SV40 large T.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Polyomavirus Transforming; Atrial Natriuretic Factor; Cell Line, Transformed; Cell Polarity; Cyclic AMP; Cyclic GMP; Isoproterenol; Kidney Tubules, Collecting; Probenecid; Rabbits | 1996 |
Evidence that guanylate cyclase is involved in modulating the resting tension and neurally-induced contraction of the guinea pig tracheal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Electric Stimulation; Guanylate Cyclase; Guinea Pigs; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Nitroprusside; Phosphodiesterase Inhibitors; Rest; Trachea | 1996 |
Role of nitric oxide/cyclic GMP pathway in the inhibitory effect of GABA and dopamine on prolactin release.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Cyclic AMP; Cyclic GMP; Dopamine; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hemoglobins; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase Inhibitors; Pituitary Gland; Prolactin; Rats; Rats, Wistar | 1996 |
Biphasic effects of intrapipette cyclic guanosine monophosphate on L-type calcium current and contraction of guinea pig ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Channels; Cyclic GMP; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Ventricular Function | 1996 |
Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease.
Topics: 1-Methyl-3-isobutylxanthine; Apolipoproteins E; Arginine; Blood Platelets; Cholesterol; Cyclic AMP; Cyclic GMP; Dimyristoylphosphatidylcholine; Enzyme Inhibitors; Guanylate Cyclase; Humans; Lipoproteins, HDL; Membrane Lipids; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines | 1997 |
The nitric oxide/cyclic GMP messenger system in olfactory pathways of the locust brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cyclic GMP; Grasshoppers; Histocytochemistry; Immunohistochemistry; Interneurons; NADP; Nitric Oxide; Olfactory Pathways; Phosphodiesterase Inhibitors; Second Messenger Systems | 1996 |
Regulation by acetylcholine of Ca2+ current in rabbit atrioventricular node cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Atrioventricular Node; Calcium Channel Blockers; Calcium Channels; Cyclic GMP; Electric Conductivity; Phosphodiesterase Inhibitors; Rabbits | 1996 |
Vectorial efflux of cGMP and its dependence on sodium in the cortical collecting duct.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Biological Transport; Cell Line; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Collecting; Mice; Nitric Oxide; Phosphodiesterase Inhibitors; Sodium | 1996 |
The effect of the vasodilator nicotinamide on cyclic nucleotide pathways in vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Imines; In Vitro Techniques; Muscle, Smooth, Vascular; Niacinamide; Oxadiazoles; Phenylephrine; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Rats, Wistar; Second Messenger Systems; Vasodilation; Vasodilator Agents | 1997 |
Effects of cGMP on L-type calcium current of adult and newborn rabbit ventricular cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Aminoquinolines; Animals; Animals, Newborn; Calcium; Calcium Channels; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Glutathione; Guanylate Cyclase; Indoles; Male; Methylene Blue; Myocardium; Nitroso Compounds; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Rabbits; S-Nitrosoglutathione; Thionucleotides; Time Factors | 1997 |
Nitric oxide-mediated cGMP synthesis in oligodendrocytes in the developing rat brain.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aging; Animals; Atrial Natriuretic Factor; Caudate Nucleus; Corpus Callosum; Cyclic GMP; Fluorescent Antibody Technique, Indirect; Gelsolin; In Vitro Techniques; Male; Nitric Oxide; Nitroprusside; Oligodendroglia; Parietal Lobe; Prosencephalon; Putamen; Rats; Rats, Inbred Lew | 1997 |
Regulation of guanosine 3':5'-cyclic monophosphate in ovine tracheal epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Epithelial Cells; Epithelium; In Vitro Techniques; Phosphodiesterase Inhibitors; Sheep; Signal Transduction; Trachea | 1997 |
Ca2+/calmodulin-dependent cyclic GMP phosphodiesterase activity in granule neurons and astrocytes from rat cerebellum.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Calcium; Calmodulin; Cells, Cultured; Cerebellum; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Enzyme Inhibitors; Granulocytes; Imidazoles; Lethal Dose 50; Neurons; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley | 1997 |
Effects of atrial natriuretic factor on glucose metabolism in isolated adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Animals; Atrial Natriuretic Factor; Carbon Dioxide; Cell Count; Cyclic AMP; Cyclic GMP; Glucose; Guanylate Cyclase; Insulin; Isoproterenol; Lipid Metabolism; Male; Natriuretic Peptide, C-Type; Peptide Fragments; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor | 1997 |
Dual effects of NMDA-induced intracellular Ca2+ elevations on cGMP levels in cultured cerebellar granule neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cells, Cultured; Cerebellum; Cyclic GMP; Excitatory Amino Acid Agonists; N-Methylaspartate; Neurons; Nitroprusside; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley | 1997 |
Effect of efflux of guanosine 3',5' cyclic monophosphate (cGMP) on the regulation of intracellular levels of cGMP in the inner medullary collecting duct.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Kidney Medulla; Kidney Tubules, Collecting; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley | 1997 |
Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylate Cyclase Toxin; Animals; Calcium; Calcium Channels; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Estrenes; Fluorescent Dyes; Fura-2; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Membrane Potentials; Necturus; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pyrrolidinones; Quaternary Ammonium Compounds; Receptors, Cytoplasmic and Nuclear; Ryanodine; Signal Transduction; Taste; Taste Buds; Thapsigargin; Virulence Factors, Bordetella | 1997 |
Comparison of ANP binding and sensitivity in brains from hypertensive and normotensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Brain; Cyclic GMP; Guanylate Cyclase; Hypertension; Hypothalamus; In Vitro Techniques; Kinetics; Male; Natriuretic Peptide, C-Type; Organ Specificity; Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Reference Values; Regression Analysis | 1997 |
Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics.
Topics: 1-Methyl-3-isobutylxanthine; Adaptation, Physiological; Ambystoma; Aminoquinolines; Aniline Compounds; Animals; Calcium; Cilia; Cyclic AMP; Cyclic GMP; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Epithelial Cells; Fluorescent Dyes; GTP-Binding Proteins; Ion Channel Gating; Membrane Potentials; Microscopy, Confocal; Olfactory Receptor Neurons; Phosphodiesterase Inhibitors; Potassium; Second Messenger Systems; Time Factors; Xanthenes | 1997 |
Stimulation of mucin exocytosis from human epithelial cells by nitric oxide: evidence for a cGMP-dependent and a cGMP-independent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Cyclic GMP; Cysteine; Enzyme Inhibitors; Epithelium; Exocytosis; Guanylate Cyclase; Humans; Hydrazines; Mucins; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Reactive Oxygen Species; Superoxide Dismutase | 1997 |
Regulation of cyclic GMP levels in the rat frontal cortex in vivo: effects of exogenous carbon monoxide and phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbon Monoxide; Cyclic GMP; Enzyme Inhibitors; Frontal Lobe; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Rats; Rats, Wistar | 1997 |
Nitric oxide and excitatory postsynaptic currents in immature rat sympathetic preganglionic neurons in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Cyclic GMP; Electric Stimulation; Evoked Potentials; Ganglia, Sympathetic; Hemoglobins; Immunohistochemistry; Nerve Fibers; Neurons; Nitric Oxide Synthase; Nitroarginine; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission | 1997 |
Dual regulation of heat-stable enterotoxin-mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bacterial Toxins; Cell Line; Cell Membrane; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Guanylate Cyclase; Humans; Kinetics; Milrinone; Phenothiazines; Purinones; Pyridones | 1997 |
The coupling of cyclic GMP and photopolarization of Pelvetia zygotes.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Aminoquinolines; Cell Division; Cell Polarity; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Light; Phaeophyceae; Phosphoric Diester Hydrolases; Zygote | 1997 |
Stimulation of eating by the second messenger cAMP in the perifornical and lateral hypothalamus.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Diterpenes; Eating; Hypothalamic Area, Lateral; Male; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Stereotaxic Techniques; Thalamus | 1997 |
Role of calcium-activated potassium channels and cyclic nucleotides on pulmonary vasoreactivity to serotonin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cyclic AMP; Cyclic GMP; Dogs; Female; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Lung; Male; Potassium Channels; Potassium Channels, Calcium-Activated; Pulmonary Circulation; Second Messenger Systems; Serotonin; Tetraethylammonium; Tetraethylammonium Compounds; Vascular Resistance | 1997 |
Regulation by calcium of the nitric oxide/cyclic GMP system in cerebellar granule cells and astroglia in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Calcium; Cells, Cultured; Cerebellum; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Male; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Vasodilator Agents | 1997 |
Autoradiographic characterization of [3H]cGMP binding sites in the rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoradiography; Binding Sites; Brain; Cyclic GMP; Dose-Response Relationship, Drug; Male; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley | 1997 |
Phosphodiesterase inhibition overcomes pulmonary vasomotor dysfunction in acute lung injury.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Cyclic GMP; Endothelium, Vascular; Endotoxins; Male; Muscle, Smooth, Vascular; Nitroprusside; Phosphodiesterase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Vasodilation | 1997 |
The effect of pentoxifylline on human neutrophil migration: a possible role for cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Cell Movement; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentoxifylline | 1997 |
Regional differentiation in the rat aorta: effects of cyclooxygenase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Aorta, Abdominal; Aorta, Thoracic; Aspirin; Cyclic GMP; Cyclooxygenase Inhibitors; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Prostaglandin H2; Prostaglandins H; Rats; Rats, Sprague-Dawley | 1997 |
Regional differentiation in the rat aorta for a novel signaling pathway: leucine to glutamate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Abdominal; Aorta, Thoracic; Biological Transport; Carbon Radioisotopes; Cattle; Cyclic GMP; Endothelium, Vascular; Glutamic Acid; Humans; In Vitro Techniques; Leucine; Male; Mice; Models, Cardiovascular; Organ Specificity; Rats; Rats, Sprague-Dawley; Signal Transduction | 1997 |
Involvement of cyclic GMP in the mode of action of a new antithrombotic agent PCA-4230; inhibition of the platelet cyclic GMP dependent phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Colforsin; Cyclic AMP; Cyclic GMP; Dihydropyridines; Drug Synergism; Fibrinolytic Agents; Kinetics; Nitroprusside; Phosphodiesterase Inhibitors; Phosphorylation; Rabbits; Serotonin; Thrombin; Vasodilator Agents | 1997 |
Effects of various selective phosphodiesterase inhibitors on muscle contractility in guinea pig ileal longitudinal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carbachol; Cell Membrane Permeability; Cyclic AMP; Cyclic GMP; Detergents; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Nitroprusside; Octoxynol; Phosphodiesterase Inhibitors; Potassium; Purinones; Type C Phospholipases; Vasodilator Agents | 1997 |
Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; beta-Galactosidase; Calcimycin; Calcium; Carotid Arteries; Cattle; Cloning, Molecular; Cyclic GMP; Cytomegalovirus; Endothelium, Vascular; Gene Transfer Techniques; Genetic Vectors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Phenylephrine; Rabbits; Recombinant Fusion Proteins | 1997 |
Regulation of cGMP by soluble and particulate guanylyl cyclases in cultured human airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Bacterial Toxins; Cells, Cultured; Cyclic GMP; Enterotoxins; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Guanylate Cyclase; Hemoglobins; Humans; Kinetics; Muscle, Smooth; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Nitroprusside; Penicillamine; Phosphodiesterase Inhibitors; Proteins; S-Nitroso-N-Acetylpenicillamine; Trachea | 1997 |
Metabotropic glutamate receptor-mediated suppression of an inward rectifier current is linked via a cGMP cascade.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Aminobutyrates; Animals; Atrial Natriuretic Factor; Benzoates; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Glycine; Ictaluridae; Ion Channel Gating; Isoquinolines; Models, Neurological; Patch-Clamp Techniques; Photoreceptor Cells; Potassium Channels; Receptors, Metabotropic Glutamate; Second Messenger Systems; Thionucleotides | 1997 |
Nitric oxide inhibits the dopamine-induced K+ current via guanylate cyclase in Aplysia neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Cyclic GMP; Dopamine; Enzyme Inhibitors; Ganglia, Invertebrate; Guanylate Cyclase; Hemoglobins; Hydroxylamine; In Vitro Techniques; Kinetics; Membrane Potentials; Neurons; Nitric Oxide; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Quinoxalines | 1997 |
Inhibitory effect of 2-phenyl-4-quinolone on serotonin-mediated changes in the morphology and permeability of endothelial monolayers.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Cattle; Cell Size; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium; Enzyme Inhibitors; Gap Junctions; Myocardium; Nitroprusside; Permeability; Protein Kinase C; Quinolones; Rats; Serotonin; Serum Albumin; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Nitric oxide mediates NMDA-evoked [3H]GABA release from chick retina cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cells, Cultured; Chick Embryo; Cyclic GMP; Dizocilpine Maleate; gamma-Aminobutyric Acid; Isoquinolines; N-Methylaspartate; Nitric Oxide; Nitroarginine; Nitrogen Oxides; Purinones; Receptors, N-Methyl-D-Aspartate; Retina; Spermine; Tritium | 1997 |
cGMP facilitates calcium current via cGMP-dependent protein kinase in isolated rabbit ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Calcium Channels; Colforsin; Cyclic GMP; Electric Conductivity; Enzyme Inhibitors; Female; Heart; Isoproterenol; Male; Membrane Potentials; Protein Kinases; Rabbits; Thionucleotides | 1998 |
Nitric oxide-induced ciliary muscle relaxation during contraction with endothelin-1 is mediated through elevation of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Ciliary Body; Cyclic GMP; Drug Combinations; Endothelin-1; Guanylate Cyclase; In Vitro Techniques; Methylene Blue; Muscle Contraction; Muscle Relaxation; Nitric Oxide; Nitroprusside; Phosphodiesterase Inhibitors | 1997 |
Secretion of a urodilatin-like immunoreactive (URO-like-IR) substance from a human kidney cell line (HEK-293).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Biological Assay; Buffers; Cell Line; Chromatography, Gel; Chromatography, High Pressure Liquid; Culture Media; Cyclic GMP; Embryo, Mammalian; Epithelial Cells; Humans; Kidney; Peptide Fragments; Radioimmunoassay; Rats; Sodium | 1996 |
Cyclic AMP and cyclic GMP concentrations in, and efflux from, preimplantation cattle embryos.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Cattle; Cyclic AMP; Cyclic GMP; Embryo Transfer; Embryonic and Fetal Development; Embryonic Development; Female; Phosphodiesterase Inhibitors; Pregnancy; Radioimmunoassay | 1997 |
Cyclic AMP stimulates the cyclic GMP egression pump in human erythrocytes: effects of probenecid, verapamil, progesterone, theophylline, IBMX, forskolin, and cyclic AMP on cyclic GMP uptake and association to inside-out vesicles.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport, Active; Colforsin; Cyclic AMP; Cyclic GMP; Dimethyl Sulfoxide; Erythrocyte Membrane; Humans; Ion Pumps; Probenecid; Progesterone; Theophylline; Verapamil | 1998 |
Inducible nitric oxide synthase augments injury elicited by oxidative stress in rat cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Arginine; Cells, Cultured; Cyclic GMP; Enzyme Induction; Glutathione Peroxidase; Heart; Heart Injuries; Kinetics; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oligonucleotides, Antisense; Oxidative Stress; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine | 1998 |
The NO/cGMP pathway and the development of neural networks in postembryonic lobsters.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Central Nervous System; Cyclic GMP; Female; Ganglia, Invertebrate; Larva; Molsidomine; Nephropidae; Nerve Net; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Signal Transduction; Smell | 1998 |
Ligand-induced conformational changes in cyclic nucleotide phosphodiesterases and cyclic nucleotide-dependent protein kinases.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Cattle; Chromatography, Gel; Chromatography, Ion Exchange; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Electrophoresis, Polyacrylamide Gel; Ligands; Lung; Molecular Weight; Protein Conformation; Recombinant Proteins | 1998 |
Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Cyclic IMP; Enzyme Activation; Enzyme Inhibitors; Nitric Oxide; Nitroprusside; Oligopeptides; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Retina; Sulfhydryl Reagents | 1998 |
Ceramide selectively inhibits calcium-mediated potentiation of beta-adrenergic-stimulated cyclic nucleotide accumulation in rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Calcium; Ceramides; Cyclic AMP; Cyclic GMP; Drug Synergism; Genistein; Isoproterenol; Male; Meperidine; Phenylephrine; Pineal Gland; Potassium; Potassium Chloride; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1998 |
Regulation of cardiac myocyte contractile function by inducible nitric oxide synthase (iNOS): mechanisms of contractile depression by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcysteine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Culture Media, Conditioned; Cyclic AMP; Cyclic GMP; Enzyme Induction; GTP-Binding Proteins; In Vitro Techniques; Isoproterenol; Lipopolysaccharides; Macrophages, Alveolar; Myocardial Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley | 1998 |
Calcium blood level modulates endogenous nitric oxide action: effects of parathroidectomy in patients with hyperparathyroidism.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma; Blood Platelets; Calcium; Cyclic GMP; Female; Humans; Hyperparathyroidism; In Vitro Techniques; Ionomycin; Ionophores; Male; Middle Aged; Nitric Oxide; Nitroprusside; Parathyroid Neoplasms; Parathyroidectomy; Phosphodiesterase Inhibitors; Postoperative Period; Stimulation, Chemical; Vasodilator Agents | 1998 |
Calcitonin gene-related peptide relaxes rabbit iris dilator smooth muscle via cyclic AMP-dependent mechanisms: cross-talk between the sensory and sympathetic nervous systems.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Cyclic GMP; Dideoxyadenosine; Dose-Response Relationship, Drug; Inositol 1,4,5-Trisphosphate; Iris; Muscle Relaxation; Muscle, Smooth; Neurons, Afferent; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Rabbits; Radioimmunoassay; Sympathetic Nervous System | 1998 |
The effect of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and charybdotoxin (CTX) on relaxations of isolated cerebral arteries to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Cerebral Arteries; Charybdotoxin; Colforsin; Cyclic GMP; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Uridine Triphosphate | 1998 |
Capacitative Ca2+ entry is involved in cAMP synthesis in mouse parotid acini.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Calcium; Calcium Channels; Carbachol; Cell Compartmentation; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; In Vitro Techniques; Ionomycin; Ionophores; Isoenzymes; Isoproterenol; Lanthanum; Mice; Muscarinic Agonists; Parotid Gland; Phosphodiesterase Inhibitors; Thapsigargin | 1998 |
Nitric oxide donors inhibit the acetylcholine-induced Cl- current in identified Onchidium neurons.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Chlorides; Cyclic GMP; Diethylamines; Electric Conductivity; Enzyme Inhibitors; Hemoglobins; Mollusca; Neurons; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines | 1998 |
Mucin-like glycoprotein secretion is mediated by cyclic-AMP and protein kinase C signal transduction pathways in rat corneal epithelium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbazoles; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelium, Corneal; Indoles; Male; Mucins; Naphthalenes; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction | 1998 |
A photoaffinity probe covalently modifies the catalytic site of the cGMP-binding cGMP-specific phosphodiesterase (PDE-5).
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Allosteric Site; Animals; Binding Sites; Binding, Competitive; Catalysis; Cattle; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Iodine Radioisotopes; Photoaffinity Labels | 1998 |
Docosahexaenoic acid reduces both cyclic nucleotide and melatonin synthesis in rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Docosahexaenoic Acids; Male; Melatonin; Norepinephrine; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Pineal Gland; Rats | 1998 |
C-type natriuretic peptide increases myocardial contractility and sinus rate mediated by guanylyl cyclase-linked natriuretic peptide receptors in isolated, blood-perfused dog heart preparations.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Dogs; Guanylate Cyclase; Heart Rate; Myocardial Contraction; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Nitroprusside; Perfusion; Polysaccharides; Propranolol; Proteins; Receptors, Atrial Natriuretic Factor; Sinoatrial Node | 1998 |
Nitric oxide-releasing oxatriazole derivatives inhibit human lymphocyte proliferation by a cyclic GMP-independent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Cyclic GMP; Guanylate Cyclase; Humans; Lymphocyte Activation; Nitric Oxide; Triazoles | 1998 |
The mechanism of Na+, K+-ATPase inhibition by atrial natriuretic factor in rat renal medulla.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Atrial Natriuretic Factor; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Kidney Medulla; Male; Papaverine; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase | 1998 |
Effect of cAMP- and cGMP-related drugs on porcine cultured ciliary muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Bucladesine; Carbachol; Cells, Cultured; Ciliary Body; Colforsin; Cyclic AMP; Cyclic GMP; Immunoenzyme Techniques; Intraocular Pressure; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Nitroprusside; Phosphodiesterase Inhibitors; Swine | 1998 |
Factors contributing to differences in the regulation of cGMP in isolated porcine pulmonary vessels.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Blotting, Western; Carbon Radioisotopes; Citrulline; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Guanylate Cyclase; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroarginine; Pulmonary Veins; Purinones; Swine | 1998 |
Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Apoptosis; Cyclic AMP; Cyclic GMP; Female; HL-60 Cells; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram | 1998 |
Human erythrocytes contain Ca2+, calmodulin-dependent cyclic nucleotide phosphodiesterase which is involved in the hydrolysis of cGMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Calcium; Calmodulin; Cyclic GMP; Erythrocytes; Humans; Hydrolysis; Phosphodiesterase Inhibitors; Purinones; Sulfonamides; Vinca Alkaloids | 1998 |
Topographical relationship between neuronal nitric oxide synthase immunoreactivity and cyclic 3',5'-guanosine monophosphate accumulation in the brain of the adult Xenopus laevis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cells, Cultured; Cyclic GMP; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphodiesterase Inhibitors; Pituitary Gland; Rabbits; Rats; Sheep; Xenopus laevis | 1998 |
Distribution of nitric oxide synthase and nitric oxide-receptive, cyclic GMP-producing structures in the rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cyclic GMP; Guanylate Cyclase; Immunohistochemistry; In Vitro Techniques; Male; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew | 1998 |
Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Bradykinin; Cardiomegaly; Cells, Cultured; Coculture Techniques; Cyclic GMP; Endothelium, Vascular; Heart; Iloprost; Indomethacin; Male; Molsidomine; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-N-Methylarginine; Phenylalanine; Protein Biosynthesis; Rats; Rats, Sprague-Dawley | 1998 |
Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Calcium Channels; Cartilage, Articular; Cell Compartmentation; Cell Fractionation; Chondrocytes; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Induction; Guanylate Cyclase; Humans; Inhibitory Concentration 50; Interleukin-1; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Signal Transduction | 1998 |
Effect of nitric oxide on the maximal velocity of shortening of a mouse skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Biomechanical Phenomena; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Penicillamine; Phosphodiesterase Inhibitors; Stereoisomerism | 1998 |
Light-increased cGMP and K+ conductance in the hyperpolarizing receptor potential of Onchidium extra-ocular photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Abdomen; Aminoquinolines; Animals; Cyclic GMP; Electric Conductivity; Electrophysiology; Enzyme Inhibitors; Membrane Potentials; Mollusca; Phosphodiesterase Inhibitors; Photic Stimulation; Photoreceptor Cells, Invertebrate; Potassium; Purinones; Second Messenger Systems; Tetraethylammonium; Vision, Ocular | 1998 |
YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Carbon Monoxide; Cyclic AMP; Cyclic GMP; Drug Synergism; Humans; Indazoles; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphorylation; Platelet Aggregation Inhibitors; Vasodilator Agents | 1998 |
Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Aldehydes; Animals; Calcium; Cell Death; Cell Survival; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cysteine Proteinase Inhibitors; Lipid Peroxidation; Mitochondria; Neurons; Neurotoxins; PC12 Cells; Phosphodiesterase Inhibitors; Purinones; Rats; Reactive Oxygen Species | 1998 |
Upregulation of angiotensin converting enzyme by atrial natriuretic peptide and cyclic GMP in human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; Peptidyl-Dipeptidase A; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Purinones; Stimulation, Chemical; Thionucleotides; Umbilical Veins; Vasodilator Agents | 1998 |
Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Aorta; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Manganese; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinase C; Purinones; Quinoxalines; Rabbits; Thionucleotides; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
Regulation of natriuretic peptide (urodilatin) release in a human kidney cell line.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Calcimycin; Cell Line; Colforsin; Culture Media; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Humans; Intracellular Fluid; Kidney; Osmolar Concentration; Peptide Fragments; Radioimmunoassay; Tetradecanoylphorbol Acetate | 1999 |
Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Aorta, Thoracic; Benzoquinones; Calcium; Calmodulin; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Female; Genistein; Hydroquinones; Imidazoles; In Vitro Techniques; Indoles; Isometric Contraction; Lactams, Macrocyclic; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Oxadiazoles; Oxazines; Quinones; Rabbits; Rifabutin; Staurosporine | 1999 |
Reciprocal antagonism coordinates C-type natriuretic peptide and mitogen-signaling pathways in fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic GMP; Enzyme Activation; Fibroblasts; Guanylate Cyclase; Mice; Mice, Inbred BALB C; Natriuretic Peptide, C-Type; Platelet-Derived Growth Factor; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Signal Transduction | 1999 |
Effect of excitatory amino acid neurotransmitters on acid secretion in the rat stomach.
Topics: 1-Methyl-3-isobutylxanthine; 2-Amino-5-phosphonovalerate; Animals; Aspartate Aminotransferases; Aspartic Acid; Cyclic AMP; Cyclic GMP; Excitatory Amino Acid Antagonists; Gastric Acid; Gastric Mucosa; Histamine; Histamine Release; Immunohistochemistry; In Vitro Techniques; Male; Muscarinic Agonists; Neurons; Oxotremorine; Pentagastrin; Piperazines; Rats; Rats, Sprague-Dawley; Stomach | 1999 |
The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Glutamic Acid; In Vitro Techniques; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Receptors, Metabotropic Glutamate; Resting Phase, Cell Cycle; Retina; Signal Transduction; Thionucleotides; Urodela | 1999 |
Effect of GABA on melatonin content in golden hamster retina.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bicuculline; Cricetinae; Cyclic AMP; Cyclic GMP; Darkness; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Male; Melatonin; Mesocricetus; Retina | 1999 |
Comparative involvement of cyclic nucleotide phosphodiesterases and adenylyl cyclase on adrenocorticotropin-induced increase of cyclic adenosine monophosphate in rat and human glomerulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenylyl Cyclases; Adolescent; Adrenocorticotropic Hormone; Adult; Animals; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Rats; Rats, Long-Evans; Zona Glomerulosa | 1999 |
Ascorbate and dehydroascorbate modulate nitric oxide-induced vasodilations of rat coronary arteries.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Ascorbic Acid; Coronary Vessels; Cyclic GMP; Dehydroascorbic Acid; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Vasodilation | 1999 |
Elevated cAMP suppresses muscarinic inhibition of L-type calcium current in guinea pig ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Calcium Channels, L-Type; Carbachol; Cyclic AMP; Cyclic GMP; Guinea Pigs; Muscarinic Agonists; Okadaic Acid; Phosphoprotein Phosphatases | 1999 |
Inhibition of cGMP accumulation in mesangial cells by bradykinin and tyrosine kinase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Genistein; Glomerular Mesangium; Guanylate Cyclase; Kidney Glomerulus; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Tyrphostins | 1999 |
Development of human and rabbit vaginal smooth muscle cell cultures: effects of vasoactive agents on intracellular levels of cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Alprostadil; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Female; Humans; Isoproterenol; Muscle, Smooth; Nitroprusside; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Piperazines; Purines; Rabbits; Sildenafil Citrate; Sulfones; Vagina; Vasoactive Intestinal Peptide; Vasodilator Agents | 1999 |
Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5).
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cattle; Centrifugation, Density Gradient; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dimerization; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Inhibitory Concentration 50; Kinetics; Leucine Zippers; Mutagenesis; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Recombinant Proteins; Sildenafil Citrate; Sulfones | 1999 |
Mechanisms involved in desensitization of particulate guanylyl cyclase in human airway smooth muscle: the role of protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; Humans; Indoles; Maleimides; Muscle, Smooth; Phorbols; Phosphodiesterase Inhibitors; Protein Kinase C; Respiratory System; Solubility; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
Nitric oxide stimulates cGMP formation in rat optic nerve axons, providing a specific marker of axon viability.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Axons; Biomarkers; Cell Hypoxia; Cell Survival; Cyclic GMP; Glucose; Hydrazines; Immunohistochemistry; In Vitro Techniques; Neuroprotective Agents; Nitric Oxide; Nitrogen Oxides; Optic Nerve; Phosphodiesterase Inhibitors; Piperazines; Pyrimidines; Rats; Rats, Wistar | 1999 |
cGMP-mediated negative-feedback regulation of endothelial nitric oxide synthase expression by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Coronary Vessels; Cyclic GMP; Down-Regulation; Endothelium, Vascular; Feedback; Guanylate Cyclase; Hemoglobins; Humans; Isosorbide Dinitrate; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Up-Regulation; Vasodilator Agents | 1999 |
Role of cyclic GMP in glutamate neurotoxicity in primary cultures of cerebellar neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glutamic Acid; Guanylate Cyclase; Neurons; Neuroprotective Agents; Nitric Oxide; Penicillamine; Phosphodiesterase Inhibitors; Rats | 1999 |
A cyclic nucleotide PDE5 inhibitor corrects defective mucin secretion in submandibular cells containing antibody directed against the cystic fibrosis transmembrane conductance regulator protein.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antibodies; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Isoproterenol; Mucins; Purinones; Pyridazines; Pyridines; Rats; Rolipram; Submandibular Gland | 1999 |
Calcium channel activation facilitated by nitric oxide in retinal ganglion cells.
Topics: 1-Methyl-3-isobutylxanthine; Ambystoma; Animals; Calcium Channel Blockers; Calcium Channels; Cyclic GMP; Cysteine; In Vitro Techniques; Larva; Membrane Potentials; Nisoldipine; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; omega-Conotoxin GVIA; Patch-Clamp Techniques; Penicillamine; Retinal Ganglion Cells; S-Nitroso-N-Acetylpenicillamine; S-Nitrosothiols; Tetrodotoxin; Thionucleotides | 2000 |
NO-mediated cGMP synthesis in cholinergic neurons in the rat forebrain: effects of lesioning dopaminergic or serotonergic pathways on nNOS and cGMP synthesis.
Topics: 1-Methyl-3-isobutylxanthine; 5,7-Dihydroxytryptamine; Acetylcholine; Animals; Carrier Proteins; Caudate Nucleus; Cholinergic Fibers; Cyclic GMP; Dopamine; Enzyme Induction; Excitatory Amino Acid Transporter 2; Frontal Lobe; Glutamate Decarboxylase; Male; Membrane Transport Proteins; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidopamine; Parvalbumins; Prosencephalon; Putamen; Rats; Rats, Inbred Lew; Receptors, Neurotransmitter; Serotonin; Stereotaxic Techniques; Tyrosine 3-Monooxygenase; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 2000 |
The role of cyclic nucleotides in the spontaneous contractility and responsiveness to nitric oxide of the rat uterus at midgestation and term.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Myometrium; Nitric Oxide; Papaverine; Phosphodiesterase Inhibitors; Pregnancy; Rats; Rats, Sprague-Dawley; Uterine Contraction; Uterus | 2000 |
Nitric oxide modulates a late step of exocytosis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Barium; Catecholamines; Cattle; Chromaffin Cells; Chromaffin Granules; Cyclic GMP; Electrochemistry; Exocytosis; Kinetics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Nitroso Compounds | 2000 |
Production of prostaglandin f(2alpha) by cultured bovine endometrial cells in response to tumor necrosis factor alpha: cell type specificity and intracellular mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Cells, Cultured; Cyclic GMP; Dinoprost; Dose-Response Relationship, Drug; Endometrium; Enzyme Inhibitors; Epithelial Cells; Estrenes; Female; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; ortho-Aminobenzoates; Penicillamine; Phospholipases A; Pyrrolidinones; Stromal Cells; Tumor Necrosis Factor-alpha | 2000 |
Photoendocrine signal transduction in pineal photoreceptors of the trout. Role of cGMP and nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Darkness; Dihydrolipoamide Dehydrogenase; Immunohistochemistry; Light; Melatonin; NADP; Nitric Oxide; Nitric Oxide Synthase; Organ Culture Techniques; Penicillamine; Photoreceptor Cells, Vertebrate; Pineal Gland; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Trout | 1999 |
Inhibition of the glutamate-induced K(+) current in identified Onchidium neurons by nitric oxide donors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Membrane; Cyclic GMP; Enzyme Inhibitors; Ganglia, Invertebrate; Glutamic Acid; Hydrazines; Mollusca; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Potassium Channels; Quinoxalines; Vasodilator Agents | 2000 |
The cGMP-dependent protein kinase stimulates the basolateral 18-pS K channel of the rat CCD.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Carbazoles; Cell Membrane; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Kidney Cortex; Kidney Tubules, Collecting; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley | 2000 |
Effects of N(G)-monomethyl-L-arginine on Ca(2+) current and nitric-oxide synthase in rat ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Calcium Channels, L-Type; Colforsin; Cyclic GMP; Enzyme Inhibitors; Milrinone; NADPH Dehydrogenase; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Rats | 2000 |
Role of BK(Ca) channels and cyclic nucleotides in synergistic relaxation of trachea.
Topics: 1-Methyl-3-isobutylxanthine; Albuterol; Animals; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Nitroprusside; Peptides; Phosphodiesterase Inhibitors; Potassium Channels; Trachea | 2000 |
Guanosine 3',5'-cyclic monophosphate mediated inhibition of cell death induced by nerve growth factor withdrawal and beta-amyloid: protective effects of propentofylline.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amyloid beta-Peptides; Animals; Apoptosis; Caspase 3; Caspases; Cyclic GMP; Dose-Response Relationship, Drug; Nerve Growth Factor; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; PC12 Cells; Penicillamine; Peptide Fragments; Phosphodiesterase Inhibitors; Rats; Rolipram; Xanthines | 2000 |
Functional identification of phosphodiesterase activity in human trabecular meshwork cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Cells, Cultured; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Humans; Isoproterenol; Nitroprusside; Piperidines; Quinazolines; Signal Transduction; Trabecular Meshwork | 2000 |
Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Caffeine; Calcium; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Gene Expression; Humans; Magnesium; Membrane Potentials; Nitroprusside; Patch-Clamp Techniques; Potassium Channels; Recombinant Proteins; Theophylline; Transfection; Xanthines | 2000 |
cGMP-dependent protein kinase mediates stimulation of L-type calcium current by cGMP in rabbit atrial cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Alkaloids; Animals; Blotting, Western; Calcium Channels, L-Type; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Heart Atria; Indoles; Isoproterenol; Myocardium; Nitric Oxide Donors; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rabbits; Stimulation, Chemical; Time Factors | 2000 |
Odorant-induced hyperpolarization and suppression of cAMP-activated current in newt olfactory receptor neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anisoles; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Membrane Potentials; Odorants; Olfactory Receptor Neurons; Patch-Clamp Techniques; Pentanols; Salamandridae | 2001 |
Parathyroid hormone potentiates nucleotide-induced [Ca2+]i release in rat osteoblasts independently of Gq activation or cyclic monophosphate accumulation. A mechanism for localizing systemic responses in bone.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Animals; Calcium; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Gene Expression; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Osteoblasts; Parathyroid Hormone; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Purinergic P2 Receptor Agonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1 | 2001 |
Nitric oxide attenuates H(2)O(2)-induced endothelial barrier dysfunction: mechanisms of protection.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Oxidants; Penicillamine; Phosphodiesterase Inhibitors; Pulmonary Artery; Quinoxalines; Swine; Thionucleotides | 2001 |
The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Guanylate Cyclase; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Purinones; Radioimmunoassay; Rats; Signal Transduction | 2001 |
Whole brain spheroid cultures as a model to study the development of nitric oxide synthase-guanylate cyclase signal transduction.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Atrial Natriuretic Factor; Brain; Cell Culture Techniques; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Guanylate Cyclase; N-Methylaspartate; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Pregnancy; Quinoxalines; Rats; Rats, Inbred Lew; Signal Transduction; Vasodilator Agents | 2000 |
Presence of soluble and particulate guanylyl cyclase in the same hippocampal astrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Atrial Natriuretic Factor; Cyclic GMP; Glial Fibrillary Acidic Protein; Guanylate Cyclase; Hippocampus; Isoenzymes; Male; Nitroprusside; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Solubility; Vasodilator Agents | 2001 |
Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Amino Acid Sequence; Animals; Base Sequence; Catalytic Domain; Cations, Divalent; Cloning, Molecular; Cyclic GMP; Dictyostelium; DNA, Recombinant; Escherichia coli; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; RNA, Messenger; Sequence Homology, Amino Acid | 2001 |
Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Aorta; Aurora Kinases; Blood Pressure; Carotid Arteries; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; GTP-Binding Proteins; Heart Failure; In Vitro Techniques; Isoproterenol; Ligation; Muscle, Smooth, Vascular; Myocardial Infarction; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Signal Transduction; Ventricular Pressure | 2001 |
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Brain; Carbazoles; Circadian Rhythm; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Darkness; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Isoenzymes; Light; Male; Mammals; Mesocricetus; Motor Activity; Oxadiazoles; Photoperiod; Quinoxalines; Signal Transduction; Suprachiasmatic Nucleus | 2001 |
The Drosophila melanogaster homologue of an insect calcitonin-like diuretic peptide stimulates V-ATPase activity in fruit fly Malpighian tubules.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drosophila melanogaster; Drosophila Proteins; Female; Hydrogen-Ion Concentration; Insect Hormones; Insect Proteins; Male; Malpighian Tubules; Membrane Potentials; Molecular Sequence Data; Muscidae; Neuropeptides; Phosphodiesterase Inhibitors; Proton-Translocating ATPases; Sequence Alignment; Urine; Vacuolar Proton-Translocating ATPases | 2001 |
Spontaneous and receptor-controlled soluble guanylyl cyclase activity in anterior pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Growth Hormone-Releasing Hormone; Guanidines; Guanylate Cyclase; Immunoblotting; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Thyrotropin-Releasing Hormone | 2001 |
Synergism between nitric oxide and hydrogen peroxide in the inhibition of platelet function: the roles of soluble guanylyl cyclase and vasodilator-stimulated phosphoprotein.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Blood Platelets; Blood Proteins; Carbazoles; Cell Adhesion Molecules; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Humans; Hydrazines; Hydrogen Peroxide; In Vitro Techniques; Indazoles; Indoles; Kinetics; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Phosphoproteins; Phosphoserine; Platelet Aggregation; Platelet Aggregation Inhibitors; Subcellular Fractions; Thrombin | 2001 |
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Milrinone; Nitroprusside; Oxadiazoles; Pentoxifylline; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Vasodilation; Vasodilator Agents | 2001 |
Localization of cGMP immunoreactivity and of soluble guanylyl cyclase in antennal sensilla of the hawkmoth Manduca sexta.
Topics: 1-Methyl-3-isobutylxanthine; Adaptation, Physiological; Animals; Cyclic GMP; Guanylate Cyclase; Immunohistochemistry; In Situ Hybridization; Male; Manduca; Nitric Oxide; Nitric Oxide Donors; Olfactory Receptor Neurons; Phosphodiesterase Inhibitors; Protein Subunits; RNA, Messenger; Sex Attractants; Signal Transduction; Up-Regulation | 2001 |
cGMP-mediated inhibition of cardiac L-type Ca(2+) current by a monoclonal antibody against the M(2) ACh receptor.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Antibodies, Monoclonal; Autoantibodies; Calcium Channels, L-Type; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanosine; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Fibers, Skeletal; Myocardium; Oxadiazoles; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Quinoxalines; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |
Mechanisms of L-type Ca(2+) current downregulation in rat atrial myocytes during heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Calcium; Calcium Channels, L-Type; Catecholamines; Cell Separation; Cyclic AMP; Cyclic GMP; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Heart Atria; Heart Failure; Male; Myocardial Infarction; Myocardium; Okadaic Acid; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Signal Transduction | 2001 |
cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Alkaloids; Animals; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Ion Channel Gating; Ion Transport; Ionomycin; Isoquinolines; Large-Conductance Calcium-Activated Potassium Channels; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Photolysis; Pituitary Gland, Posterior; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Quinoxalines; Signal Transduction; Sodium; Sodium Channels; Sulfonamides; Thionucleotides | 2001 |
Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Amyloid; Animals; Cerebral Ventricles; Cyclic GMP; Genes, fos; In Vitro Techniques; Islet Amyloid Polypeptide; Male; Neurons; omega-N-Methylarginine; Peptide Fragments; Peptides; Rats; Rats, Wistar; Second Messenger Systems | 2001 |
Differential responses of newborn pulmonary arteries and veins to atrial and C-type natriuretic peptides.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cyclic GMP; Gene Expression Regulation; Guanylate Cyclase; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Nitric Oxide; Oxadiazoles; Pulmonary Artery; Pulmonary Veins; Quinoxalines; Receptors, Atrial Natriuretic Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sheep; Transcription, Genetic | 2002 |
Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Calcium; Calcium Signaling; Cyclic AMP; Cyclic GMP; Humans; In Vitro Techniques; Kinetics; Linoleic Acid; Linoleic Acids; Nitro Compounds; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Thrombin; Tyrosine; Vasodilator Agents | 2002 |
Total parenteral nutrition modulates hormone release by stimulating expression and activity of inducible nitric oxide synthase in rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Glucagon; Glucose; Hormones; In Vitro Techniques; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Parenteral Nutrition, Total; Rats; Rats, Sprague-Dawley; Reference Values | 2001 |
Dynamics of nitric oxide during simulated ischaemia-reperfusion in rat striatal slices measured using an intrinsic biosensor, soluble guanylyl cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Biosensing Techniques; Brain Ischemia; Cyclic GMP; Guanylate Cyclase; NADPH Dehydrogenase; Neostriatum; Neurons; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2002 |
Cyclic AMP-mediated increase in L-type calcium current (ICa,L) by nitroglycerin in guinea-pig ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Signaling; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dialysis; Guinea Pigs; Heart Ventricles; Isoproterenol; Methylene Blue; Nitroglycerin | 2002 |
Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Animals; Cells, Cultured; Centrifugation, Density Gradient; Cyclic GMP; Fibroblasts; Fluorescent Antibody Technique; Guanylate Cyclase; Heart Ventricles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth; Myocardium; Natriuretic Peptide, C-Type; Octoxynol; Phosphodiesterase Inhibitors; Phosphorylation; Rats; Receptors, Atrial Natriuretic Factor; Tissue Distribution | 2002 |
Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary artery.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Cytosol; Isoenzymes; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Tunica Media; Vasoconstriction | 2002 |
Platelet cyclic guanosine monophosphate production during menstrual cycle in healthy women.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Blood Platelets; Cyclic GMP; Estradiol; Female; Follicular Phase; Humans; Ionomycin; Ionophores; Luteal Phase; Menstrual Cycle; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Ovulation; Reference Values | 2002 |
Relationship between bicarbonate and cyclic nucleotide in the promoting effects on head-to-head agglutination in boar spermatozoa.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Male; Papaverine; Purinergic P1 Receptor Antagonists; Sodium Bicarbonate; Sperm Agglutination; Sperm Head; Swine; Theophylline | 2002 |
Effects of hepatocyte growth factor on cyclic nucleotide-dependent signaling and steroidogenesis in rat ovarian granulosa cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Hepatocyte Growth Factor; Humans; Insulin-Like Growth Factor I; Male; Ovary; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Steroids | 2002 |
Potentiation of slow component of delayed rectifier K(+) current by cGMP via two distinct mechanisms: inhibition of phosphodiesterase 3 and activation of protein kinase G.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Atrial Natriuretic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Delayed Rectifier Potassium Channels; Enzyme Activation; Female; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium Channels; Potassium Channels, Voltage-Gated; Sinoatrial Node | 2002 |
Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents; Calcium; Cell Degranulation; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Integrins; Linoleic Acid; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitro Compounds; Phosphodiesterase Inhibitors; Superoxides; Tetradecanoylphorbol Acetate | 2002 |
No evidence for inhibition of ENaC through CFTR-mediated release of ATP.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amiloride; Animals; Colon; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Enzyme Inhibitors; Epithelial Sodium Channels; In Vitro Techniques; Mice; Nucleoside-Diphosphate Kinase; Oocytes; Peptide Fragments; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Sodium Channels; Uridine Triphosphate; Xenopus | 2002 |
Distribution of NO-induced cGMP-like immunoreactive neurones in the abdominal nervous system of the crayfish, Procambarus clarkii.
Topics: 1-Methyl-3-isobutylxanthine; Abdomen; Animals; Astacoidea; Cyclic GMP; Female; Ganglia; Immunohistochemistry; Male; Nervous System; Neurons; Nitric Oxide; Potassium; Signal Transduction | 2002 |
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2002 |
Hydrolysis of cyclic GMP in rat peritoneal macrophages.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcium; Calmodulin; Cells, Cultured; Cyclic GMP; Hydrolysis; Macrophages, Peritoneal; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Solubility | 2002 |
Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Muscle Relaxation; Neuropeptides; Nitric Oxide; Oxadiazoles; Quinoxalines; Radioimmunoassay; Starfish; Stomach | 2003 |
Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Glutathione; Humans; Multidrug Resistance-Associated Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Ribosomal Proteins; Time Factors | 2003 |
Speract induces calcium oscillations in the sperm tail.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anion Transport Proteins; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cyclic AMP; Cyclic GMP; Extracellular Space; Intracellular Fluid; Male; Membrane Potentials; Nickel; Niflumic Acid; Oligopeptides; Potassium; Sea Urchins; Signal Transduction; Sperm Head; Sperm Motility; Sperm Tail | 2003 |
Inhibition of ovarian steroidogenesis by cyclic GMP in a fly.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Alkaloids; Animals; Brain; Calcium Channels; Carbazoles; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diptera; Ecdysteroids; Female; Indoles; Organ Culture Techniques; Ovary; Phosphodiesterase Inhibitors; Quinazolines; Signal Transduction; Stimulation, Chemical | 2003 |
Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Antineoplastic Agents, Phytogenic; Arachidonic Acids; Breast Neoplasms; Cell Division; Cyclic AMP; Cyclic GMP; Dactinomycin; Enzyme Activation; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; Receptors, Estrogen; Resveratrol; Rolipram; Stilbenes; Tamoxifen; Tumor Cells, Cultured | 2003 |
Preventive effect of zaprinast and 3-isobutyl, 1-methylxanthine (phosphodiesterase inhibitors) on gastric injury induced by nonsteroidal antiinflammatory drugs in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Disease Models, Animal; Drug Interactions; Gastric Mucosa; Gastritis; Male; Phosphodiesterase Inhibitors; Primary Prevention; Purinones; Random Allocation; Rats; Rats, Wistar; Sensitivity and Specificity | 2003 |
The role of tryptophan 1072 in human PDE3B inhibitor binding.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; COS Cells; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Escherichia coli; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Phosphodiesterase Inhibitors; Protein Binding; Quinolones; Sequence Alignment; Tryptophan | 2003 |
Cardiac enkephalins attenuate vagal bradycardia: interactions with NOS-1-cGMP systems in canine sinoatrial node.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Bradycardia; Cyclic GMP; Dogs; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enzyme Inhibitors; Indazoles; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parasympathomimetics; Penicillamine; Phosphodiesterase Inhibitors; Sinoatrial Node; Vagus Nerve | 2003 |
Role of cyclic nucleotides in regulation of pulmonary artery tone in rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Dipyridamole; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pulmonary Artery; Rabbits; Signal Transduction; Sympathomimetics; Theophylline; Vasodilator Agents | 2003 |
cGMP and glutathione-conjugate transport in human erythrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Antibodies, Monoclonal; Biological Transport, Active; Cell Line; Cell Membrane; Clotrimazole; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Erythrocytes; Glutathione; Glyburide; Humans; Immunoblotting; Ion Channels; Multidrug Resistance-Associated Proteins; Propionates; Protein Kinase C; Quinolines; Tritium | 2003 |
Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Alternative Splicing; Amino Acid Sequence; Base Sequence; Blotting, Western; Cell Line; Cloning, Molecular; Cyclic GMP; DNA, Complementary; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Isoenzymes; Male; Molecular Sequence Data; Phosphodiesterase Inhibitors; Piperazines; Purines; Purinones; Recombinant Proteins; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Sildenafil Citrate; Sulfones | 2003 |
Peroxynitrite-induced cardiac depression: role of myofilament desensitization and cGMP pathway.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Calcium; Calcium Channel Blockers; Cyclic GMP; Enzyme Inhibitors; Female; Homeostasis; Male; Myocardial Contraction; Myocardium; Nicardipine; Oxidants; Perfusion; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2003 |
Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Amino Acid Sequence; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Escherichia coli; Humans; Models, Molecular; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid | 2004 |
Nitric oxide is involved in growth regulation and re-orientation of pollen tubes.
Topics: 1-Methyl-3-isobutylxanthine; Benzoates; Cyclic GMP; Dose-Response Relationship, Drug; Flowers; Fluorescein; Imidazoles; Lilium; Nitric Oxide; Peroxisomes; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones | 2004 |
Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Catalytic Domain; Crystallography, X-Ray; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dimerization; Humans; Isoenzymes; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Protein Structure, Tertiary; Substrate Specificity | 2004 |
Cyclic adenosine monophosphate (cAMP) increases natriuretic peptide receptor C (NPR-C) expression in human aortic smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Aorta; Atrial Natriuretic Factor; Bucladesine; Carbazoles; Cell Culture Techniques; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Guanylate Cyclase; Humans; Indoles; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Binding; Pyrroles; Receptors, Atrial Natriuretic Factor; RNA, Messenger; Signal Transduction | 2004 |
Effects of nitric oxide and tumor necrosis factor-alpha on production of prostaglandin F2alpha and E2 in bovine endometrial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Western; Cattle; Cyclic GMP; Dinoprost; Dinoprostone; Endometrium; Enzyme Inhibitors; Female; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Phosphodiesterase Inhibitors; Time Factors; Tumor Necrosis Factor-alpha; Uterus | 2004 |
Nitric oxide regulates the levels of cGMP accumulation in the cricket brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Gryllidae; Guanylate Cyclase; Immunohistochemistry; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sodium Chloride; Soluble Guanylyl Cyclase | 2004 |
A sea urchin egg jelly peptide induces a cGMP-mediated decrease in sperm intracellular Ca(2+) before its increase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Signaling; Cell Polarity; Cyclic AMP; Cyclic GMP; Hydrogen-Ion Concentration; Kinetics; Male; Nucleotides, Cyclic; Oligopeptides; Photolysis; Sea Urchins; Sodium-Calcium Exchanger; Spermatozoa; Thiourea; Ultraviolet Rays | 2004 |
Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Ulcer Agents; Brain; Cattle; Cyclic AMP; Cyclic GMP; Gastric Mucosa; Hydrolysis; Isoenzymes; Male; Myocardium; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Stomach; Triazines | 2004 |
Dual effect of diazepam on cGMP levels in rat brain slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cerebellum; Cerebral Cortex; Cyclic GMP; Diazepam; Hippocampus; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Lew | 2004 |
Upregulation of guanylyl cyclase expression and activity in striatum of MPTP-induced parkinsonism in mice.
Topics: 1-Methyl-3-isobutylxanthine; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Cyclic GMP; Dopamine Agents; Guanylate Cyclase; Mice; MPTP Poisoning; Nitric Oxide; Parkinson Disease; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Subunits; Signal Transduction; Tyrosine 3-Monooxygenase; Up-Regulation | 2004 |
Cyclase and phosphodiesterase activity on pre-T lymphoid human cells, treated with dimethyl sulfoxide (DMSO).
Topics: 1-Methyl-3-isobutylxanthine; Apoptosis; Cell Line; Chromatography, High Pressure Liquid; Cyclic AMP; Cyclic GMP; Dimethyl Sulfoxide; Free Radical Scavengers; Humans; Phosphoric Diester Hydrolases; T-Lymphocytes; Time Factors | 2004 |
Guinea-pig lung adenylyl and guanylyl cyclase and PDE activities associated with airway hyper- and hypo-reactivity following LPS inhalation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Administration, Inhalation; Animals; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Guinea Pigs; Histamine; Lipopolysaccharides; Lung; Male; Phosphoric Diester Hydrolases | 2005 |
The effect of a nitric oxide donor on the synthesis of cGMP in Hymenolepis diminuta: a radiometric study.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Hymenolepis diminuta; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Radioimmunoassay; Rats; Time Factors | 2005 |
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Membrane Proteins; Naproxen; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Purinones; Synovial Membrane; Time Factors | 2005 |
Phosphodiesterases 1 and 2 regulate cellular cGMP level in rabbit submandibular gland cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Hydrolysis; Isoenzymes; Methacholine Chloride; Phosphoric Diester Hydrolases; Rabbits; Submandibular Gland | 2005 |
Pathological implications of iNOS expression in central white matter: an ex vivo study of optic nerves from rats with experimental allergic encephalomyelitis.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Arginine; Biomarkers; CD11b Antigen; CD2 Antigens; Cyclic GMP; DEET; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Encephalomyelitis, Autoimmune, Experimental; Female; Guanylate Cyclase; Guinea Pigs; Hydrazines; Immunohistochemistry; Macrophages; Microscopy, Electron, Transmission; Myelin Basic Protein; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Optic Chiasm; Optic Nerve; Ornithine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Time Factors | 2005 |
Membrane association of nitric oxide-sensitive guanylyl cyclase in cardiomyocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzylamines; Blood Platelets; Blotting, Western; Calcium; Cell Membrane; Cells, Cultured; Cyclic GMP; Cytosol; Guanylate Cyclase; Immunohistochemistry; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Staurosporine; Sulfonamides | 2005 |
Expression of neuronal nitric oxide synthase (nNOS) and nitric-oxide-induced changes in cGMP in the urothelial layer of the guinea pig bladder.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Female; Guinea Pigs; Immunohistochemistry; Male; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins c-kit; Second Messenger Systems; Urinary Bladder; Urothelium | 2005 |
Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Binding Sites; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Down-Regulation; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Folic Acid Antagonists; GC Rich Sequence; Humans; Leukemia, T-Cell; Luciferases; Membrane Transport Proteins; Nuclear Proteins; Okadaic Acid; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Platelet Aggregation Inhibitors; Promoter Regions, Genetic; Protein Phosphatase 2; Protein Processing, Post-Translational; Reduced Folate Carrier Protein; Sp1 Transcription Factor; Thionucleotides; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2006 |
Cyclic AMP mediates serotonin-induced synaptic enhancement of lateral giant interneuron of the crayfish.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adrenergic alpha-Agonists; Analysis of Variance; Animals; Astacoidea; Cyclic AMP; Cyclic GMP; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Ganglia, Invertebrate; Habituation, Psychophysiologic; Interneurons; Male; Membrane Potentials; Octopamine; Phosphodiesterase Inhibitors; Serotonin; Synapses | 2005 |
Cyclic nucleotide kinases and tachyzoite-bradyzoite transition in Toxoplasma gondii.
Topics: 1-Methyl-3-isobutylxanthine; Animals; beta-Galactosidase; Cell Differentiation; Chloramphenicol O-Acetyltransferase; Colforsin; Culture Media; Cyclic AMP; Cyclic GMP; Gene Expression Regulation, Developmental; Genes, Protozoan; Genes, Reporter; Heat-Shock Proteins; Life Cycle Stages; Nitroprusside; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Protozoan Proteins; Signal Transduction; Toxoplasma; Toxoplasmosis; Tubulin | 2006 |
A role for cyclic nucleotide monophosphates in synaptic modulation by a crayfish neuropeptide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astacoidea; Cyclic GMP; Neuropeptides; Nucleotides; Nucleotides, Cyclic; Peptides; Synapses; Synaptic Transmission; Thionucleotides | 2006 |
Provasopressin expression by breast cancer cells: implications for growth and novel treatment strategies.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents; Antibodies, Monoclonal; Arginine Vasopressin; Blotting, Western; Breast Neoplasms; Cell Proliferation; Cyclic GMP; Dexamethasone; Female; Glycopeptides; Humans; Hypothalamus; Immunoenzyme Techniques; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; Phosphodiesterase Inhibitors; Phosphorylation; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Glutamine; Humans; Imidazoles; Molecular Structure; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Protein Conformation; Purines; Sildenafil Citrate; Substrate Specificity; Sulfones; Triazines; Vardenafil Dihydrochloride | 2006 |
Nitric oxide production from rat adipocytes is modulated by beta3-adrenergic receptor agonists and is involved in a cyclic AMP-dependent lipolysis in adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Adipocytes; Adrenergic Agonists; Adrenergic beta-3 Receptor Agonists; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Lipolysis; Male; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 2006 |
Mechanisms of antiplatelet activity of PC-09, a newly synthesized pyridazinone derivative.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Triphosphate; Alprostadil; Animals; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Imidazoles; Indomethacin; Naphthalenes; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridazines; Rabbits; Thrombin; Thromboxane A2; Thromboxane-A Synthase | 2006 |
Chronic hypoxic decreases in soluble guanylate cyclase protein and enzyme activity are age dependent in fetal and adult ovine carotid arteries.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Carotid Arteries; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Female; Guanylate Cyclase; Hypoxia; Nitric Oxide; Phosphodiesterase Inhibitors; Pregnancy; Pregnancy, Animal; RNA, Messenger; Sheep; Thionucleotides | 2006 |
Regulation of protein synthesis in Y-organs of the blue crab (Callinectes sapidus): involvement of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Autoradiography; Brachyura; Bucladesine; Colforsin; Cyclic AMP; Cyclic GMP; Cycloheximide; Ecdysteroids; Electrophoresis, Polyacrylamide Gel; Endocrine Glands; Methionine; Protein Biosynthesis; Signal Transduction; Time Factors | 2006 |
Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Adenine; Animals; Atrial Natriuretic Factor; Biological Transport; Cell Compartmentation; Cell Membrane; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclic Nucleotide-Gated Cation Channels; Heart Ventricles; Humans; Ion Channel Gating; Ion Channels; Isoenzymes; Male; Myocytes, Cardiac; Natriuretic Peptide, Brain; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Rats; Rats, Wistar; Recombinant Fusion Proteins; Sarcolemma; Second Messenger Systems; Sildenafil Citrate; Solubility; Sulfones | 2006 |
Profiling of functional phosphodiesterase in mesangial cells using a CRE-SEAP-based reporting system.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaline Phosphatase; Animals; Apoptosis; Cell Proliferation; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Male; Mesangial Cells; Rats; Rats, Sprague-Dawley; Response Elements | 2006 |
Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Calcium; Cell Compartmentation; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Guanylate Cyclase; Humans; Ion Channels; Male; Manganese; Myocytes, Smooth Muscle; Natriuretic Peptides; Nitric Oxide; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; S-Nitroso-N-Acetylpenicillamine; Signal Transduction | 2006 |
Profiling human phosphodiesterase genes and splice isoforms.
Topics: 1-Methyl-3-isobutylxanthine; Alternative Splicing; Calcium; Calmodulin; Cyclic AMP; Cyclic GMP; Enzyme Activation; Exons; Gene Expression; Gene Expression Profiling; Humans; Isoenzymes; Phosphoric Diester Hydrolases; Sensitivity and Specificity | 2006 |
Cyclic nucleotide-gated ion channels in rod photoreceptors are protected from retinoid inhibition.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Ambystoma; Animals; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Diterpenes; Guanylate Cyclase; Ion Channels; Light; Microspectrophotometry; Patch-Clamp Techniques; Retinal Rod Photoreceptor Cells; Retinaldehyde; Retinoids; Retinol-Binding Proteins; Retinol-Binding Proteins, Plasma; Rhodopsin; Rod Cell Outer Segment; Vitamin A | 2006 |
Exogenous nitric oxide stimulated collagen type I expression and TGF-beta1 production in keloid fibroblasts by a cGMP-dependent manner.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Blotting, Western; Cells, Cultured; Collagen Type I; Cyclic GMP; Female; Fibroblasts; Humans; Keloid; Male; Middle Aged; Nitric Oxide; Transforming Growth Factor beta | 2007 |
Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Apoptosis; Calcium; Calpain; Caspase 3; Catalase; Cell Line; Cell Survival; Cyclic GMP; Cytochromes c; Docosahexaenoic Acids; Glutathione Peroxidase; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Oxidative Stress; Phosphodiesterase Inhibitors; Photoreceptor Cells, Vertebrate; Reactive Oxygen Species; Retinal Degeneration | 2007 |
Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Bucladesine; Calcium; Cell Adhesion Molecules; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Indazoles; Kinetics; Microfilament Proteins; Nucleotides, Cyclic; Oligopeptides; Peptide Fragments; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Thionucleotides; Thrombin | 2007 |
Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport; Cell Membrane; Cyclic GMP; Cytosol; Fibroblasts; Humans; Hyaluronic Acid; Models, Biological; Multidrug Resistance-Associated Proteins; NG-Nitroarginine Methyl Ester; Purinones; RNA Interference; Xanthines | 2007 |
Phosphodiesterase type 2 and the homeostasis of cyclic GMP in living thalamic neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Homeostasis; Mice; Mice, Inbred C57BL; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Organ Culture Techniques; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Signal Transduction; Thalamus | 2007 |
Ibudilast-induced decreases in cytosolic Ca(2+) level and contraction in rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Dose-Response Relationship, Drug; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Phenylephrine; Phosphodiesterase Inhibitors; Potassium; Pyridines; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 2007 |
Phosphodiesterase-5A and neutral endopeptidase activities in human adipocytes do not control atrial natriuretic peptide-mediated lipolysis.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adult; Atrial Natriuretic Factor; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Humans; Kinetics; Lipolysis; Neprilysin; Phosphodiesterase 5 Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiorphan; Time Factors | 2007 |
Involvement of cyclic GMP in phytochrome-controlled flowering of Pharbitis nil.
Topics: 1-Methyl-3-isobutylxanthine; Cotyledon; Cyclic GMP; Dipyridamole; Flowers; Ipomoea nil; Light; Nitroprusside; Photoperiod; Phytochrome | 2008 |
Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Binding Sites; Carbolines; Catalytic Domain; Crystallography, X-Ray; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Histidine; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Kinetics; Molecular Sequence Data; Mutation; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Sequence Alignment; Sildenafil Citrate; Sulfones; Tadalafil; Thermodynamics; Triazines; Tyrosine; Vardenafil Dihydrochloride | 2007 |
Potentiation of ATP- and bradykinin-induced [Ca2+]c responses by PTHrP peptides in the HaCaT cell line.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Bradykinin; Calcium; Carbazoles; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; Humans; Indoles; Keratinocytes; Parathyroid Hormone-Related Protein; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Signal Transduction | 2008 |
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Dipyridamole; Female; Guanylate Cyclase; Histamine; Humans; In Vitro Techniques; Isoenzymes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthyridines; Nitroprusside; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Serotonin; Umbilical Arteries; Vasodilator Agents | 2008 |
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide-Gated Cation Channels; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Guanylate Cyclase; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2008 |
Two autocrine pathways to regulate cyclic GMP synthesis in cultured human retinal pigment epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Autocrine Communication; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Guanylate Cyclase; Humans; Immunohistochemistry; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Oxadiazoles; Phosphodiesterase Inhibitors; Pigment Epithelium of Eye; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
NO-mediated cGMP synthesis in cultured cholinergic neurons from the basal forebrain of the fetal rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cholinergic Fibers; Cyclic GMP; Enzyme Inhibitors; Fetus; Hydrazines; Immunohistochemistry; In Situ Hybridization; Microscopy, Fluorescence; Nitric Oxide; Nitric Oxide Donors; Prosencephalon; Rats; Rats, Inbred Lew | 2008 |
Cyclic-AMP-dependent proliferation of a human osteoblast cell line (HOS cells) induced by hydroxyapatite: effect of exogenous nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Arginase; Cell Communication; Cell Differentiation; Cell Line; Colforsin; Colorimetry; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dichlororibofuranosylbenzimidazole; Durapatite; Guanylate Cyclase; Humans; Nitric Oxide; Nitric Oxide Donors; Osteoblasts; Penicillamine; Phosphodiesterase Inhibitors; Rolipram; S-Nitroso-N-Acetylpenicillamine | 2008 |
Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood-Air Barrier; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Mice; Mice, Knockout; Nitric Oxide; Phosphodiesterase Inhibitors; Ventilator-Induced Lung Injury | 2008 |
Expression regulation and function of Pref-1 during adipogenesis of human mesenchymal stem cells (MSCs).
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Calcium-Binding Proteins; Cyclic AMP; Cyclic GMP; Dexamethasone; Gene Expression Regulation; Humans; Indomethacin; Insulin; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Mesenchymal Stem Cells; Mice; Models, Biological; Time Factors | 2009 |
Nitric oxide and cyclic nucleotide signal transduction modulates synaptic vesicle turnover in human model neurons.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Cell Differentiation; Cell Line, Tumor; Colforsin; Cyclic GMP; Enzyme Inhibitors; Exocytosis; Humans; Isoquinolines; Microtubule-Associated Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroso Compounds; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Pyridinium Compounds; Quaternary Ammonium Compounds; Signal Transduction; Sulfonamides; Synapsins; Synaptic Vesicles; Synaptotagmin I; Teratocarcinoma; Time Factors | 2009 |
Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; ADP-ribosyl Cyclase; Animals; Arterioles; Calcium; Calcium Signaling; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Peptides; Phosphodiesterase Inhibitors; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley | 2010 |
Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation.
Topics: 1-Methyl-3-isobutylxanthine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; Mitogen-Activated Protein Kinases; Neoplasms; Nitric Oxide; Nitroso Compounds; Phosphorylation; Pyrazoles; Pyridines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Structure-Activity Relationship | 2010 |
TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Cell Line; Cell Movement; Cell Proliferation; Cyclic GMP; Endothelial Cells; Enzyme Activation; Extracellular Matrix; Humans; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Phospholipase C gamma; Phosphoric Diester Hydrolases; Phosphorylation; Proto-Oncogene Proteins c-akt; Tissue Inhibitor of Metalloproteinase-2; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Cyclic GMP; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Guanylate Cyclase; Humans; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinoxalines; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Umbilical Cord | 2010 |
Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids; Animals; Animals, Newborn; Astrocytes; Bridged Bicyclo Compounds, Heterocyclic; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Cytochromes c; DNA Fragmentation; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Gene Expression Regulation; In Situ Nick-End Labeling; Interferon-gamma; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Phosphatidylserines; Phosphodiesterase Inhibitors; Polyamines; Polysaccharides; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Tetrazolium Salts; Thiazoles | 2010 |
Development of nitrergic neurons in the nervous system of the locust embryo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Citrulline; Cyclic GMP; Embryo, Nonmammalian; Enzyme Activators; Ganglia, Invertebrate; Indazoles; Locusta migratoria; NADPH Dehydrogenase; Nerve Regeneration; Nervous System; Neurites; Neurons; Neuropil; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Signal Transduction | 2010 |
Serotonin is a facilitatory neuromodulator of synaptic transmission and "reinforces" long-term potentiation induction in the vertical lobe of Octopus vulgaris.
Topics: 1-Methyl-3-isobutylxanthine; Afferent Pathways; Animals; Brain; Brain Chemistry; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Long-Term Potentiation; Memory; Neuropil; Octopodiformes; Organ Culture Techniques; Reinforcement, Psychology; Serotonin; Synaptic Transmission | 2010 |
Grueneberg ganglion neurons are finely tuned cold sensors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Calcium; Calcium Signaling; Cold Temperature; Colforsin; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Ganglia, Sensory; Green Fluorescent Proteins; In Vitro Techniques; Isothiocyanates; Mice; Mice, Transgenic; Microscopy, Confocal; Nasal Cavity; Olfactory Bulb; Olfactory Marker Protein; Olfactory Pathways; Phosphodiesterase Inhibitors; Pyrimidinones; Sensory Receptor Cells; Sodium Channel Blockers; Tetrodotoxin; Thermosensing; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2010 |
CNP/GC-B system: a new regulator of adipogenesis.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Cyclic GMP; Dexamethasone; Glucocorticoids; Humans; Insulin; Mice; Natriuretic Peptide, C-Type; Phosphodiesterase Inhibitors; Receptors, Atrial Natriuretic Factor | 2010 |
Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; Alanine; Alkynes; Animals; Aorta, Thoracic; Clone Cells; Cyclic AMP; Cyclic GMP; Cystathionine gamma-Lyase; Cysteine; Endothelial Cells; Glycine; Humans; Hydrogen Sulfide; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; RNA, Small Interfering; Vasodilation | 2010 |
Functional and molecular characterization of rod-like cells from retinal stem cells derived from the adult ciliary epithelium.
Topics: 1-Methyl-3-isobutylxanthine; Adult Stem Cells; Animals; Cell Differentiation; Chloride Channels; Cilia; CLC-2 Chloride Channels; Cyclic GMP; Dependovirus; Epithelial Cells; Gene Expression Regulation; Green Fluorescent Proteins; Ion Channel Gating; Light; Light Signal Transduction; Mice; Mice, Inbred C57BL; Retina; Retinal Rod Photoreceptor Cells; Rhodopsin; Spheroids, Cellular | 2012 |
Characterization of nitric oxide signaling pathways in the mouse retina.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calbindins; Cyclic GMP; Gene Expression Regulation; Guanylate Cyclase; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Retina; S-Nitroso-N-Acetylpenicillamine; S100 Calcium Binding Protein G; Signal Transduction; Soluble Guanylyl Cyclase; Visual Pathways | 2012 |
Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Cell Adhesion Molecules; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; Microfilament Proteins; Natriuretic Peptides; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Platelet Aggregation | 2014 |
Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atrium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Function; Benzofurans; Calcium-Binding Proteins; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Phosphodiesterase Inhibitors; Phosphorylation; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Agonists; Swine; Troponin I | 2013 |
Dual role of cyclic GMP in cardiac cell survival.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbazoles; Cell Adhesion Molecules; Cell Line; Cell Survival; Cyclic GMP; Fluorescence; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Marine Toxins; Microfilament Proteins; Myocytes, Cardiac; Oxazoles; Phosphoproteins; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins c-akt; Rats | 2013 |
Aged Garlic Extract Inhibits Human Platelet Aggregation by Altering Intracellular Signaling and Platelet Shape Change.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Cardiovascular Agents; Cyclic AMP; Cyclic GMP; Fibrinogen; Garlic; Humans; Nitric Oxide; Phosphodiesterase Inhibitors; Plant Extracts; Platelet Aggregation; Signal Transduction | 2016 |
Poly (I:C) impairs NO donor-induced relaxation by overexposure to NO via the NF-kappa B/iNOS pathway in rat superior mesenteric arteries.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Endothelium, Vascular; Gene Expression Regulation; Interferon-Induced Helicase, IFIH1; Male; Mesenteric Artery, Superior; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitroprusside; Poly I-C; Rats; Rats, Wistar; RNA Helicases; Signal Transduction; Tissue Culture Techniques; Toll-Like Receptor 3; Vasodilation | 2017 |
Endothelium-independent vasodilator effects of nobiletin in rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Citrus; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Flavones; In Vitro Techniques; Male; Phenylephrine; Potassium Channels, Calcium-Activated; Rats, Wistar; Vasoconstriction; Vasodilation | 2019 |
cAMP signaling primes lung endothelial cells to activate caspase-1 during
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Alprostadil; Animals; Caspase 1; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic GMP; Dinoprostone; Endothelial Cells; Gene Expression Regulation; Host-Pathogen Interactions; Inflammasomes; Interleukin-1beta; Lung; Primary Cell Culture; Pseudomonas aeruginosa; Rats; Rolipram; Signal Transduction; Single-Cell Analysis | 2020 |
Glabridin Relaxes Vascular Smooth Muscles by Activating BK
Topics: 1-Methyl-3-isobutylxanthine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Humans; Ion Channel Gating; Isoflavones; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Peptides; Phenols; Phenylephrine; Phosphodiesterase Inhibitors; Saphenous Vein; Vasodilation | 2021 |