1-methyl-3-isobutylxanthine has been researched along with colforsin in 1385 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 337 (24.33) | 18.7374 |
| 1990's | 667 (48.16) | 18.2507 |
| 2000's | 291 (21.01) | 29.6817 |
| 2010's | 81 (5.85) | 24.3611 |
| 2020's | 9 (0.65) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Kajimoto, N; Nishimura, Y; Suzuki, A; Usui, H; Yamanishi, Y | 1 |
| de Koning, HP; Huchedé, B; Jenks, BG; Roubos, EW | 1 |
| Sanders, MM; Skoufos, E | 1 |
| Crook, RB; Yabu, JM | 1 |
| Chen, X; Jahan, H; Kanaide, H; Kobayashi, S; Nishimura, J; Shikasho, T | 1 |
| Nowak, JZ; Zurawska, E | 1 |
| Koch, B; Lutz-Bucher, B | 1 |
| Forbush, B; Lytle, C; Pon, DJ; Sen, AK; Torchia, J | 1 |
| Assender, JW; Hallett, MB; Newby, AC; Southgate, KM | 1 |
| Hampson, EC; Vaney, DI; Weiler, R | 1 |
| Albert, PR; Civelli, O; Liu, YF; Zhou, QY | 1 |
| Behrens, UD; Kirsch, M; Wagner, HJ | 1 |
| Kamei, C; Mukai, T; Tasaka, K | 1 |
| Eisenberg, HM; Hulsebosch, CE; Lu, Y; Morgan, B; Perez-Polo, JR; Pizzo, DP; Werrbach-Perez, K; Westlund, KN | 1 |
| Hata, F; Takeuchi, T; Yagasaki, O | 1 |
| Altiok, N; Fredholm, BB | 2 |
| Asfari, M; Halban, PA; Janjic, D; Li, G; Meda, P; Wollheim, CB | 1 |
| Audette, M; Bouillon, M; Boulianne, R; Fortier, MA | 1 |
| Hanke, K; Möller, K; Perrin, D; Söling, HD | 1 |
| Fertel, RH; Kniss, DA; Su, HC | 1 |
| Bear, CE; Reyes, EF | 1 |
| Barnea, A; Magni, P | 1 |
| Andersen, RN; Buster, JE; Casson, PR; Klein, NA; Kramer, RE | 1 |
| Bataille, D; Demirpence, E; Gros, L; Jarrousse, C; Kervran, A | 1 |
| Denis-Pouxviel, C; Gamet, L; Murat, JC; Paris, H; Remaury, A; Remesy, C; Valet, P | 1 |
| Brake, J; Johnson, AL | 1 |
| Richter, J | 1 |
| Berry-Kravis, E; Huttenlocher, PR | 1 |
| Chang, AS; King, SC; Lam, DM; Tiller, AA | 1 |
| Balcarek, JM; Chilton, FH; Livi, GP; Torphy, TJ; Undem, BJ; White, JR | 1 |
| Chiba, S; Furukawa, Y; Karasawa, Y | 1 |
| Dan, Y; Lohof, AM; Poo, MM; Quillan, M | 1 |
| Eidelman, O; Etcheberrigaray, R; Fox, C; Goping, G; Malden, E; Pollard, HB; Roberts, D; Yedgar, S | 1 |
| Conanan, LB; Crutchley, DJ; Solomon, DE | 1 |
| Bhattacharyya, S; Chaudhary, J; Das, C | 1 |
| Bockman, RS; Guidon, PT; Rapuano, BE; Salvatori, R | 1 |
| Barbier, AJ; Lefebvre, RA | 1 |
| Benito, M; de Juan, C; Fabregat, I | 1 |
| Cooper, DM; Mollard, P; Rodman, D; Zhang, Y | 1 |
| Kaji, T; Koizumi, F; Sakamoto, M; Yamamoto, C | 1 |
| Broad, S; Brooks, SF; Herget, T; Rozengurt, E | 1 |
| Levavi-Sivan, B; Yaron, Z | 1 |
| Chavez-Noriega, LE; Stevens, CF | 2 |
| Copolov, DL; Huang, W; Lee, D; Lim, AT; Yang, Z | 3 |
| Antonov, AS; Kabaeva, NV; Perov, NA; Petrova, LE | 1 |
| Klugmann, T; Mons, I; Wenzel, BE | 1 |
| Fischer, MJ; Janssen, LH; Nijkamp, FP; van Oosterhout, AJ | 1 |
| Pahapill, PA; Schlichter, LC | 1 |
| Zatz, M | 1 |
| Beinfeld, MC | 2 |
| Nokta, MA; Pollard, RB | 1 |
| Aucouturier, S; Bernard, C; Chayvialle, JA; Cuber, JC | 1 |
| Chang, JP; van der Kraak, G; van Goor, F; Wong, AO | 1 |
| Bishopric, NH; Sato, B; Webster, KA | 1 |
| Bressler, JP; Brightman, MW; Tao-Cheng, JH | 1 |
| Ache, BW; Michel, WC | 1 |
| Barber, R; Butcher, RW; Goka, TJ | 1 |
| MacLeod, KM; Ray, A | 2 |
| Enero, MA; Kazanietz, MG | 2 |
| Daykin, K; Hall, IP; Townsend, P; Widdop, S | 1 |
| Rivedal, E; Roseng, LE; Sanner, T | 1 |
| Breant, B; Lavergne, C; Rosselin, G | 1 |
| Frick, KK; Scher, CD | 1 |
| Anderson, RJ; Breckon, R; Dillingham, MA; Dixon, BS; Kaehny, MM | 1 |
| Bowers, PN; Klein-Nulend, J; Raisz, LG | 1 |
| Cohen, P; Hardie, DG; Haystead, TA; Moore, F | 1 |
| Morley, GP; Neild, TO | 1 |
| Amiel, C; Friedlander, G; Le Grimellec, C | 1 |
| Johnson, RA; Toews, ML | 1 |
| Cohen, GM; Lewis, CP; Smith, LL | 1 |
| Arita, H; Nakano, T; Ohara, O; Teraoka, H | 3 |
| Mante, S; Minneman, KP | 1 |
| Barker, LA; McDonough, KH; Smith, LW; Winbery, SL | 1 |
| Cline, MJ; Horvai, AE; Kalman, D; O'Lague, PH; Wong, B | 1 |
| Ajiro, K; Nishikawa, Y; Shibata, K | 1 |
| Ishimura, Y; Kizaki, H; Suzuki, K; Tadakuma, T | 1 |
| Fujimoto, S; Matsuda, T | 1 |
| Boege, F; Cantrill, RC; Hahn, M; Heithier, H; Kurstjens, NP | 1 |
| Donaldson, J; Hall, IP; Hill, SJ | 1 |
| Lomri, A; Marie, PJ | 1 |
| Chilton, FH; Goldman, D; Torphy, TJ; Undem, BJ | 1 |
| Dawson, G; McAtee, P | 2 |
| Akasu, T; Tokimasa, T | 2 |
| Zawalich, KC; Zawalich, WS | 1 |
| Gertler, A; Pines, M; Shamay, A; Waksman, M | 1 |
| Hackmiller, RC; Jumblatt, JE | 1 |
| Deckmyn, H; Kienast, J; Van Geet, C; Vermylen, J; Wittevrongel, C | 1 |
| Gross, RE; Lu, XY; Rubin, CS | 1 |
| Paulais, M; Teulon, J | 1 |
| Middleton, A; Middleton, B | 2 |
| Doi, K; Matsunaga, T; Mori, N | 1 |
| Koren, R; Liberman, A; Narinsky, R; Novogrodsky, A; Ravid, A; Rotem, C | 1 |
| Pedersen, PS | 1 |
| D'Ambra, R; Efrat, S; Fleischer, N; Starr, RG; Surana, M | 1 |
| Bali, JP; Choquet, A; Leonard, A; Magous, R | 1 |
| Takuma, T | 1 |
| Iwashita, S; Mitsui, K; Senshu-Miyaike, M; Shoji-Kasai, Y | 1 |
| Adachi, Y; Furuyama, J; Hatanaka, M; Ishii, K; Sakamoto, H | 1 |
| Brubaker, PL; Drucker, DJ; Greenberg, GR | 1 |
| Kraut, JA; Mishler, DR; Nagami, GT | 1 |
| Aten, RF; Behrman, HR; Margolin, Y | 1 |
| Johnson, SM | 1 |
| Ago, JM; Dewhirst, FE; Stashenko, P | 1 |
| Adler, R; Avendano, G; Butler, BJ; Iuvone, PM | 1 |
| Osborne, NN | 2 |
| Chiba, T; Fujita, T; Kadowaki, S; Morishita, T; Nakamura, A; Yamaguchi, A; Yamatani, T | 1 |
| Chen, AB; Fei, DT; Gross, MC; Lofgren, JL; Mora-Worms, M | 1 |
| Argent, BE; Garton, AJ; Gray, MA; Greenwell, JR | 1 |
| Ball, RL; Carpenter, G; Tanner, KD | 1 |
| Björntorp, P; De Pergola, G; Giorgino, R; Holmäng, A; Svedberg, J | 1 |
| Fong, JC | 1 |
| Canalis, E; Centrella, M; McCarthy, TL | 1 |
| Löffler, G; Pöll-Jordan, G; Schmidt, W | 1 |
| Krystosek, A; Puck, TT | 1 |
| Nowak, JZ; Schorderet, M; Sek, B | 2 |
| Fukuda, A; Minami, T; Nabekura, J; Oomura, Y | 1 |
| Almaraz, L; González, C; Pérez-García, MT | 2 |
| Duan, DS; Eiger, S; Lameh, J; Sadée, W; Yu, VC | 1 |
| Buffey, J; Friedmann, PS; Macneil, S; Wren, F | 1 |
| Deana, A; Scuka, M | 1 |
| Dasarathy, Y; Fanburg, BL; Lanzillo, JJ; Stevens, J | 1 |
| Johnson, SM; Pillai, NP | 1 |
| Malinowska, DH | 1 |
| Ballard, PL; Ertsey, R; Odom, MW | 1 |
| Moser, A; Schuster, O | 1 |
| Copolov, D; Dean, B; Lim, AT | 1 |
| Nathan, C; Sanchez, E | 1 |
| Groome, JR; Watson, WH | 3 |
| Beavo, J; Jacobson, KL; McPhee, C; Singh, JC; Watson, EL | 1 |
| Greenfield, LJ; Hackett, JT; Linden, J | 1 |
| Schafer, JA; Troutman, SL | 1 |
| Gullberg, U; Lantz, M; Lindvall, L; Olsson, I | 1 |
| Burnham, BL; Chick, WL; Clark, SA | 1 |
| Dempster, DW; Murrills, RJ | 1 |
| Harvath, L; Robbins, JD; Russell, AA; Seamon, KB | 1 |
| Jefferson, AB; Schulman, H | 1 |
| Alexandropoulos, K; Foster, DA; Joseph, CK; Qureshi, SA; Spangler, R | 1 |
| Olashaw, NE; Pledger, WJ; Rhee, SG | 1 |
| Chabardès, D; Montégut, M; Siaume-Perez, S; Zhou, Y | 1 |
| Schwarzschild, MA; Zigmond, RE | 1 |
| Chaudhari, A; Gupta, S; Kirschenbaum, MA | 1 |
| Chihara, T; Nomura, Y; Tokumitsu, Y; Uehara, T | 1 |
| Müller, TH; Partridge, LD; Swandulla, D | 1 |
| Mehmet, H; Morris, C; Rozengurt, E | 1 |
| Jessen, KR; Mirsky, R; Morgan, L | 1 |
| Andreasen, P; Georg, B; Riccio, A | 1 |
| Degani, H; DeJordy, JO; Salomon, Y | 2 |
| Braden, G; Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, J; Shipp, E | 1 |
| Hatanaka, M; Ito, S; Negishi, M; Okuda-Ashitaka, E; Sugama, K | 1 |
| Arnold, R; Bächle, R; Fehmann, HC; Göke, B; Göke, R; Wagner, B | 1 |
| Malamed, S; Perez, FM; Scanes, CG | 2 |
| Eckert, BS; Yeagle, PL | 1 |
| Arneson-Rotert, LJ; Hoffman, JM; Johnson, RA; Toews, ML | 1 |
| Hohmann, HP; Kolbeck, R; Remy, R; van Loon, AP | 1 |
| Iizuka, H; Matsuo, S | 1 |
| Frings, S; Lindemann, B | 1 |
| Hoffmann, A; Klöcking, HP | 1 |
| Wainwright, LK; Wainwright, SD | 1 |
| De Mey, JG; Heesen, BJ | 1 |
| Kohno, S; Matsubayashi, H; Tsuru, H | 1 |
| Jackson, B; Kidwell, D; Ott, C; Subramaniam, S | 1 |
| Hashemi, F; Niles, LP | 1 |
| Gil, J; Higgins, T; Rozengurt, E | 1 |
| Dittman, WA; Ito, T; Maruyama, I; Ogawa, K; Osame, M; Saito, H; Soejima, Y; Yamamoto, S | 1 |
| Hanafusa, T; Kitajima, K; Mashita, K; Matsui, I; Miyagawa, J; Mori-Tanaka, M; Oda, Y; Tajima, K; Tarui, S | 1 |
| Hamet, P; Tremblay, J | 1 |
| Langeler, EG; van Hinsbergh, VW | 1 |
| Eklove, H; Webb, RA | 1 |
| Champigny, G; Lazdunski, M; Verrier, B | 1 |
| Efrat, S; Fleischer, N; Surana, M | 1 |
| Lachowicz, L; Turski, WA | 1 |
| Defeo-Jones, D; Haskell, KM; Jones, RE; McAvoy, EM; Oliff, A; Vuocolo, GA; Wegrzyn, RJ | 1 |
| Orekhova, NM | 1 |
| Classen, M; Fürlinger, C; Janczewska, I; Schepp, W; Schmidtler, J; Schusdziarra, V; Weigert, N | 1 |
| Nunes, JP; Soares-da-Silva, P; Villanueva, MM | 1 |
| Farndale, RW; Martin, BR; Meikle, MC; Sandy, JR | 1 |
| Baidan, LV; Fertel, RH; Wood, JD; Xia, Y | 1 |
| Beauchamp, RD; Kim, SW; Thompson, JC; Townsend, CM | 1 |
| Killen, PD; Neilson, EG; Wolf, G | 1 |
| Cornet, M; Delpire, E; Gilles, R | 1 |
| Andrews, PA; Howell, SB; Mann, SC | 1 |
| Cagliero, E; Lorenzi, M; Maiello, M; Roth, T; Roy, S | 1 |
| Brooks, JW; Chedid, M; Mizel, SB; Yoza, BK | 1 |
| Shikada, K; Tanaka, S; Yamamoto, A | 1 |
| Harvey, RD; Hume, JR; Jurevicius, JA | 1 |
| Nicholson, D; Reid, A; Sawynok, J | 1 |
| Bhalla, VK; Cool, DR; Ganapathy, V; Leibach, FH; Mahesh, VB | 1 |
| Kennedy, TG; Yee, GM | 1 |
| Borski, RJ; Grau, EG; Helms, LM | 1 |
| Grenfell, S; Ray, K; Rollins, P; Sadler, H; Smithers, N; Solari, R; Thompson, N; Witham, S | 1 |
| Khademazad, M; Loessberg, P; Muallem, S; Whisenant, N; Zhang, BX | 1 |
| Dehaye, JP; Turner, RJ | 1 |
| Clark, WA; Decker, RS; LaPres, JJ; Lesch, M; Rudnick, SJ | 1 |
| Gupta, S; Schlondorff, D; Shen, Z; Singhal, PC | 1 |
| Hellwig, B; Joost, HG | 1 |
| Hemmings, BA; Jans, DA; Resink, TJ | 1 |
| Jansen, PL; Ottenhoff, R; Oude Elferink, RP; Roelofsen, H | 1 |
| Nicholson, D; Sawynok, J; White, TD | 1 |
| Baier, W; Busse, R; Kaissling, B; Kurtz, A | 1 |
| Baluyut, AR; Muthusamy, N; Subbarao, B | 1 |
| Chneiweiss, H; Cordier, J; Glowinski, J | 1 |
| Bosch, AI; de Kloet, ER; Molewijk, HE; Schipper, J; Sijbesma, H | 1 |
| Anderson, RJ; Breckon, R; Colston, D | 1 |
| Berrow, NS; Lacey, RJ; Morgan, NG; Scarpello, JH | 1 |
| Fabbro, D; Knesel, J; Nagamine, Y; Ziegler, A | 1 |
| Majewski, H; Minatoguchi, S | 1 |
| Chu, HM; Comb, MJ; Kobierski, LA; Tan, Y | 1 |
| Chao, AC; Katayama, Y | 1 |
| Asa, SL; Brubaker, PL; Drucker, DJ; Greenberg, GR | 1 |
| Jakubowiak, A; Janecki, A; Steinberger, A | 1 |
| Fong, JC; Hong, PK; Leu, SJ | 1 |
| Levine, JD; Taiwo, YO | 1 |
| Guth, P; Norris, C; Ricci, A | 1 |
| Baarends, WM; Blok, LJ; Grootegoed, JA; Hoogerbrugge, JW; Parmentier, M; Post, M; Themmen, AP; Vassart, G | 1 |
| Heim, HK; Oestmann, A; Sewing, KF | 1 |
| Dewey, D; Douglas, PB; Putnam, RW | 1 |
| Hescheler, J; Wallukat, G; Wobus, AM | 1 |
| Arroyo, JA; Cervera, T; Ortiz, MA; Perez, A; Pou, JM | 1 |
| Donoghue, DJ; Scanes, CG | 1 |
| Jachno, K; Johnston, MJ; Marley, PD; Thomson, KA | 1 |
| Carroll, JM; Evinger, MJ; Goodman, HM; Joh, TH | 1 |
| Baylink, DJ; Mohan, S | 1 |
| Fayet, G; Hovsépian, S | 2 |
| Cochaux, P; Dumont, JE; Van Sande, J | 1 |
| Hanson, RL; Isaacson, CM | 1 |
| Lisman, JE; O'Day, PM | 1 |
| Reutter, K; Ruoff, HJ; Schepp, W | 1 |
| Feyen, JH; Nijweide, PJ; van der Plas, A | 1 |
| Grodsky, GM; Schmid-Formby, F | 1 |
| Costa, ME; Katz, KH; Ojeda, SR; Urbanski, HF | 1 |
| Rink, TJ; Sage, SO | 1 |
| Hamet, P; Lachance, B; Tremblay, J | 1 |
| Challis, JR; Mitchell, BF; Skinner, K; Warrick, C | 1 |
| Mashita, K; Moriwaki, K; Shimizu, M; Tajima, K; Tarui, S | 1 |
| Alberts, P; Ogren, VR; Sellström, AI | 1 |
| Nickols, GA | 1 |
| Lindemann, JP; Watanabe, AM | 1 |
| Agus, ZS; Civan, MM; Kelepouris, E; Ziyadeh, FN | 1 |
| Mattson, MP; Spaziani, E | 2 |
| Hoskins, DD; Vijayaraghavan, S | 1 |
| Besharse, JC; Iuvone, PM | 1 |
| Christensen, S; Dousa, TP; Homma, S; Kusano, E; Murayama, N; Werness, JL; Yusufi, AN | 1 |
| Aucoin, RR; Feyereisen, R; Meller, VH; Tobe, SS | 1 |
| Asem, E; Hertelendy, F; Marrone, BL | 1 |
| Nezu, E; Yoneyama, T; Yoshimura, K | 2 |
| Corda, D; Kohn, LD | 1 |
| Lange, AB; Orchard, I | 1 |
| de Chaffoy de Courcelles, D; Roevens, P; van Belle, H | 1 |
| Bell, PD | 1 |
| Pollock, AS; Strewler, GJ; Warnock, DG | 1 |
| Beaulieu, M; Felder, R; Kebabian, JW | 1 |
| Conti, M; Geremia, R; Monaco, L; Stefanini, M | 1 |
| Bardin, CW; Boitani, C; Mather, JP | 1 |
| Bonjour, JP; Caverzasio, J; Rizzoli, R | 1 |
| Dere, WH; Rapoport, B | 1 |
| Ahn, HS; Eardley, D; Prioli, N; Watkins, R | 1 |
| Chao, WT; Walkenbach, RJ | 1 |
| Hedin, L; Holmes, PV; Janson, PO | 1 |
| Catherwood, BD; Chenoweth, DE; Rubin, JE | 1 |
| Mulder, AH; Schoffelmeer, AN; Wierenga, EA | 1 |
| Eckhardt, L; Imamura, K; Kimura, T; Schulz, I | 1 |
| Dunn, MJ; Sato, M | 1 |
| Fatemi, SH | 1 |
| Hwang, WI; Kim, YS; Sack, TL | 1 |
| Labrie, F; Simard, J | 1 |
| Band, V; Farooq, A; Kharbanda, SM; Murugesan, K | 1 |
| Arita, J; Kimura, F | 1 |
| Cline, WH; Metz, MA; Nickols, GA | 1 |
| Madison, DV; Nicoll, RA | 1 |
| Erlichman, J; Fleischer, N; Leiser, M; Litvin, Y | 1 |
| Hornicek, FJ; Jin, S; McKenzie, JM; Neylan, D; Zakarija, M | 1 |
| Danoff, A; Fleischer, N; Pasmantier, R; Schubart, UK | 1 |
| Blackmore, PF; Exton, JH | 1 |
| Hakeda, Y; Kumegawa, M; Kurihara, N; Maeda, N; Natakani, Y; Yoshino, T | 1 |
| Olansky, L; Shew, RL; Sutton, JK; Yee, JA | 1 |
| Bickel, M; Herling, AW | 1 |
| Fyles, JM; Howell, SL; Jones, PM | 1 |
| Racowsky, C | 1 |
| Stinnakre, J; Van Renterghem, C | 1 |
| Hescheler, J; Kameyama, M; Trautwein, W | 1 |
| Alvarez, R; Amirian, DA; Chen, MC; Soll, AH; Toomey, M | 1 |
| Pappano, AJ; Rardon, DP | 1 |
| Chiu, AT; McCall, DE; Timmermans, PB | 1 |
| Kwon, HB; Schuetz, AW | 1 |
| Malemud, CJ; Mills, TM; Papay, RS; Shuckett, R | 1 |
| Kondo, S; Miyagawa, I; Morita, T; Weiss, RM; Wheeler, MA | 1 |
| Ausiello, DA; Axelrod, L; Kieffer, JD; Ryan, CA; Shaw, JL | 1 |
| Dewitt, J; Tepperman, HM; Tepperman, J | 1 |
| Hoffman, BB; Lee, CH; Tsujimoto, G | 1 |
| Wojcik, WJ; Xu, J | 1 |
| Curella, P; Ham, L; Tank, AW | 1 |
| Boudreaux, MK; Catalfamo, JL; Dodds, WJ; Slauson, DO | 1 |
| Al-Turk, WA; Othman, S; Shaheen, O | 1 |
| Asem, EK; Hertelendy, F | 2 |
| Erlichman, J; Fleischer, N; Leiser, M | 1 |
| Campagnoni, AT; Dawson, G; Szuchet, S; Vartanian, T | 1 |
| Fredholm, BB; Lerner, U; Ransjö, M | 1 |
| Nemeth, PR; Palmer, JM; Wood, JD; Zafirov, DH | 1 |
| Barnea, A; Cho, G | 1 |
| Copelas, L; Feldman, MD; Grossman, W; Gwathmey, JK; Morgan, JP; Phillips, P; Schoen, FJ; Warren, SE | 1 |
| Gonzalez, OF; Kreisberg, JI; Troyer, DA; Venkatachalam, MA | 1 |
| Ishitoya, J; Takenawa, T | 1 |
| Blazynski, C; Cohen, AI | 1 |
| Aitken, RJ; Irvine, S; Mattei, A | 1 |
| Lindmar, R; Löffelholz, K; Sandmann, J | 1 |
| Berman, MI; Jerdack, G; Nayfeh, SN; Thomas, CG | 1 |
| Anakwe, OO; Moger, WH | 1 |
| Boyd, AE; Hill, RS; Oberwetter, JM | 1 |
| Finger, W; Martin, C | 1 |
| Botterell, SH; Hemmings, BA; Jans, DA | 1 |
| Bastiani, P; Dang, J; Fouchier, F | 1 |
| Farber, DB; Hughes, BA; Miller, SS | 1 |
| Benson, SC; Bush, GL | 1 |
| Costello, A; Handwerger, S; Harman, I; Markoff, E | 1 |
| Browning, ET; Etgen, AM | 1 |
| Cline, WH; Nickols, GA | 1 |
| Chiba, T; Fujita, T; Inui, T; Kadowaki, S; Saito, Y; Yamaguchi, A; Yamatani, T | 1 |
| Costello, A; Handwerger, S; Harman, I; Sane, A | 1 |
| Kostić, MM; Krause, EG; Maretzki, D; Rapoport, SM; Zivković, R | 1 |
| Brussaard, AB; de Graan, PN; Eberle, AN; Gamboni, G; Girard, J | 1 |
| Ascoli, M; Euffa, J; Segaloff, DL | 1 |
| Brenner, GM; Chen, WY; Hugman, LE; Robbins, RK; Wince, LC | 1 |
| Ibayashi, H; Imamura, K; Kimura, T; Shinozaki, H | 1 |
| Niki, A; Niki, H; Niki, I; Tamagawa, T | 1 |
| Downer, RG; Gole, JW; Orr, GL | 1 |
| Campeau, JD; di Zerega, GS; Ujita, EL | 1 |
| Linden, J | 1 |
| Darbeida, H; Durand, P | 1 |
| Makara, GB; Rappay, G; Szentendrei, T | 1 |
| Singh, JC; Watson, EL | 1 |
| Greeff, K; Schmitt, M | 1 |
| Kondo, Y; Okajima, F; Tokumitsu, Y; Ui, M | 1 |
| Brady, MJ; Nairn, AC; Nichols, RA; Palfrey, HC | 1 |
| Ahene, CA; Ealey, PA; Emmerson, JM; Marshall, NJ | 1 |
| Dickinson, KE; Hirschowitz, BI; Komiyama, K; Matsumoto, H; Shirakawa, T | 1 |
| Haslam, RJ; Murphy, W; Williams, KA | 1 |
| Bednar, MS; Broner, FA; Hubbard, JR; Sledge, CB; Steinberg, JJ | 1 |
| Hara, M; Ogawa, A; Sasaki, H; Sato, N; Suda, K; Takahashi, K; Wada, K; Wakasugi, K; Yamatani, K | 1 |
| Cary, DA; Mendelsohn, FA | 1 |
| Kagawa, S; Matsuoka, A; Nakao, K; Wakabayashi, S | 1 |
| Orchard, I; Pannabecker, T | 1 |
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| Hirono, C; Iwasa, Y; Shiba, Y; Shintani, T; Sugita, M | 1 |
| Alvarez, E; Cairrão, E; Morgado, M; Santos-Silva, AJ; Verde, I | 1 |
| Surmacz, L; Wiejak, J; Wyroba, E | 1 |
| Mühlbauer, E; Peschke, E; Stumpf, I | 1 |
| Bara, H; Sambanis, A | 1 |
| Bonifacio, E; Brigatti, C; Giordano, T; Malosio, ML; Meldolesi, J; Podini, P | 1 |
| Choi, IW; Jung, SH; Kim, HT; Kim, HU; Koo, JH; Kwon, KB; Park, BH; Park, JW; Yoon, HY | 1 |
| Katz, U; Nagel, W; Rozman, A | 1 |
| Alarma-Estrany, P; Crooke, A; Mediero, A; Peláez, T; Pintor, J | 1 |
| Alton, EW; Boyd, AC; Gill, DR; Griesenbach, U; Holder, E; Hyde, SC; Munkonge, FM; Porteous, D; Smith, SN; Sumner-Jones, S | 1 |
| Ali, DW; Balt, LN; Coutts, CA | 1 |
| Sosroseno, W; Sugiatno, E | 1 |
| Jo, R; Osawa, S; Weiss, ER | 1 |
| Anand-Ivell, R; Heng, K; Ivell, R; Wagaarachchi, P | 1 |
| Baillie, GS; Brandon, N; Charych, E; Collins, DM; Dunlop, AJ; Herberg, FW; Houslay, MD; Murdoch, H; Prinz, A; Wang, Q | 1 |
| Clementi, ME; Galtieri, A; Giardina, B; Masala, D; Misiti, F; Orsini, F; Tellone, E | 1 |
| Barman, SA; White, RE; Zhu, S | 1 |
| Lissitzky, JC; Lombardo, D; Parriaux, D; Ristorcelli, E; Vérine, A; Verrando, P | 1 |
| Chaudhari, N; Dvoryanchikov, G; Roberts, CD; Roper, SD | 1 |
| Mizoguchi, A; Saito, T; Seino, S; Shibasaki, T; Sugawara, K | 1 |
| Bernard, M; Voisin, P | 1 |
| Ahn, DS; Chae, JE; Chang, CH; Cho, YL; Kim, MH; Park, WK | 1 |
| Ares, GR; Caceres, PS; Ortiz, PA | 1 |
| Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S | 1 |
| Elsholtz, HP; Gaisano, HY; Hu, J; Huang, Y; Jin, T; Li, H; Li, RK; Liu, L; Su, B; Sun, J; Wang, P; Wang, Q; Wu, J; Zhang, N; Zhang, Y | 1 |
| Abbruzzese, A; Caraglia, M; Chiosi, E; Di Gesto, D; Illiano, F; Illiano, G; Marra, M; Naviglio, S; Romano, M; Sorrentino, A; Sorvillo, L; Spina, A | 1 |
| Bogatcheva, NV; Kovalenkov, Y; Poirier, C; Verin, AD; Zemskova, MA | 1 |
| Barrett, MO; Burianek, LE; Carter, RL; Das, A; Fricks, IP; Harden, TK; Jacobson, KA; Ko, H; Lazarowski, ER; Zhou, Y | 1 |
| Bicker, G; Stern, M; Tegenge, MA | 1 |
| Dragomir, A; Johannesson, M; Lazorova, L; Nilsson, HE; Roomans, GM | 1 |
| Harada, N; Hosaka, T; Kim Chung, le T; Nakaya, Y; Sakai, T; Sakaue, H; Yoshida, M | 1 |
| Bongmba, OY; Chitnis, A; Kulkarni, M; LeDay, AM; Njie-Mbye, YF; Ohia, SE; Onyema, CC; Opere, CA | 1 |
| Abramczyk, AM; Chan, C; Seitz, LC; Zhang, L | 1 |
| Norante, FA; Taft, AS; Yoshino, TP | 1 |
| Abumrad, NA; Liu, Y; Su, X; Zhou, D | 1 |
| Alper, SL; Bradford, EM; Gawenis, LR; Prasad, V; Shull, GE | 1 |
| Cid, LP; Flores, CA; Sepúlveda, FV | 1 |
| Barrionuevo, G; Card, JP; Cosgrove, KE; Galván, EJ; Mauna, JC; Meriney, SD; Thiels, E | 1 |
| Einstein, EB; Hon, BJ; Johnson, BN; Mateer, MJ; Melnikoff, DE; Patterson, CA; Reddi, J; Regan, KA; Schulz, S; Tallent, MK | 1 |
| Biel, M; Leinders-Zufall, T; Pyrski, M; Schmid, A; Zufall, F | 1 |
| Bonfleur, ML; Boschero, AC; Carneiro, EM; Oliveira, CA; Ribeiro, RA; Vanzela, EC | 1 |
| Chang, LY; Chao, CC; Cheng, TH; Chou, CH; Huang, CF; Kuo, CS; Leung, YM; Lu, DY | 1 |
| Sakaba, T; Yao, L | 1 |
| Albuz, FK; Armstrong, DT; Gilchrist, RB; Lane, M; Sasseville, M; Thompson, JG | 1 |
| Chen, M; Li, F; Ning, G; Wang, N; Wang, X; Wu, L; Yang, Y; Yuan, G; Zhang, R; Zhou, L | 1 |
| Berger, J; Clauss, WG; Fronius, M; Richter, K | 1 |
| Guo, S; Mathur, P; Wagle, M | 1 |
| Bouillet, E; Christ-Crain, M; Dembinski, K; Frey, DM; Grisouard, J; Keller, U; Müller, B; Peterli, R; Radimerski, T; Timper, K; Zulewski, H | 1 |
| Barata, LE; de Parijós, AM; de Souza, RZ; Maia, JG; Sampaio, Lde F | 1 |
| Cvijic, ME; Kang, L; Kong, Y; Shei, GJ; Wang, Y | 1 |
| Britton, F; Dixon, R; Hwang, S; Sanders, K; Ward, S | 1 |
| Hayashi, K; Miwa, S; Nishida, H; Ohnari, I; Shirai, T; Sugimoto, N; Takeuchi, A; Tsuchiya, H; Yachie, A | 1 |
| Kazemi, A; Razmkhah, F; Safa, M; Zaker, F | 1 |
| Kongsuphol, P; Kraidith, K; Kunzelmann, K; Schreiber, R | 1 |
| Bishnoi, M; Cao, DS; Evans, MS; Jeffry, JA; Pabbidi, RM; Pimentel, F; Premkumar, LS; Raisinghani, M; Zhong, L | 1 |
| Herbert, TP; Moore, CE; Ponuwei, GA; Tee, AR; Willars, GB; Xie, J | 1 |
| Bekkali, N; Benninga, MA; Bijlsma, PB; de Jonge, HR; Desjeux, JF; Taminiau, JA; van den Wijngaard, RM; van der Steeg, AF | 1 |
| Kam, WR; Sullivan, DA | 1 |
| Kongsuphol, P; Kunzelmann, K; Ousingsawat, J; Schreiber, R | 1 |
| Kim, HM; Lee, GH; Lee, JW; Lee, MS; Moon, EY | 1 |
| Berson, DM; Van Hook, MJ; Wong, KY | 1 |
| Guo, M; Liu, X; Nie, Z; Qing, M; Xu, X; Yao, S; Zhou, J | 1 |
| Ding, C; Lu, M | 1 |
| Albrecht, E; Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S | 1 |
| Guan, G; Kagawa, H; Nagahama, Y; Oba, Y; Senthilkumaran, B; Sreenivasulu, G; Sudhakumari, CC | 1 |
| Amaral, MD; Bertuzzo, CS; Bonadia, LC; Cardoso, SR; Felício, V; Kmit, A; Kunzelmann, K; Marson, FA; Ramalho, AS; Ribeiro, AF; Ribeiro, JD; Ribeiro, MA; Servidoni, MF; Sousa, L; Sousa, M; Uliyakina, I; Vinagre, AM | 1 |
| Gilchrist, RB; Kelly, JM; Rose, RD; Sutton-McDowall, ML; Thompson, JG | 1 |
| Bartic, C; Callewaert, G; Jans, D; Lammertyn, J; Micholt, E; Nicolai, B | 1 |
| Boot-Handford, RP; MacLennan, KA; Robins, GG; Sandle, GI | 1 |
| Ballard, HJ; Cai, W; Lu, L; Tu, J | 1 |
| Giovanniello, JR; Koren, G; Li, W; Lu, Y; Moshal, K; Organ-Darling, LE; Roder, K; Vernon, AN | 1 |
| Herrick, JR | 1 |
| Kirken, RA; Nagy, ZS; Rodriguez, G; Ross, JA | 1 |
| Belluzzi, O; Borin, M; Fogli Iseppe, A; Gambardella, C; Pignatelli, A | 1 |
| Brito, M; Castro, LR; Girault, JA; Guiot, E; Hervé, D; Korn, CW; Paupardin-Tritsch, D; Polito, M; Vincent, P | 1 |
| De Vos, M; Gilchrist, RB; Guzman, L; Ren, Z; Ritter, LJ; Smitz, J; Sutton-McDowall, ML; Thompson, JG; Wang, X; Zeng, HT | 1 |
| Calejo, AI; Gonçalves, PP; Jorgacevski, J; Kreft, M; Kucka, M; Stojilkovic, SS; Zorec, R | 1 |
| Burdyga, A; Conant, A; Costello, E; Haynes, L; Jalink, K; Neoptolemos, J; Sutton, R; Tepikin, A; Zhang, J | 1 |
| Charó, NL; Galigniana, MD; Guber, S; Piwien-Pilipuk, G; Schwartz, J; Susperreguy, S; Toneatto, J | 1 |
| Dwinell, MB; Hauser, AD; Roy, I; Williams, CL; Wilson, JM; Zimmerman, NP | 1 |
| Fuentes, J; Márquez, L | 1 |
| Deachapunya, C; Poonyachoti, S | 1 |
| Baulain, U; Diederich, M; Großfeld, R; Heinzmann, J; Herrmann, D; Lucas-Hahn, A; Niemann, H; Timmermann, B; Ulloa, SM | 1 |
| Im, DS; Ishii, S; Jin, Y; Mogi, C; Murata, N; Okajima, F; Sato, K; Tobo, A; Tobo, M | 1 |
| Kreft, M; Vardjan, N; Zorec, R | 1 |
| Garcia-Diaz, A; Henderson, CE; Johnson-Kerner, B; Kim, YA; Lamas, NJ; Roybon, L; Wichterle, H | 1 |
| Amano, M; Funahashi, Y; Hamaguchi, T; Kaibuchi, K; Nakamuta, S; Nishioka, T; Shohag, MH; Takano, T; Yura, Y | 1 |
| Beyhan, Z; Ezoe, K; Kato, K; Kato, Y; Kobayashi, T; Miki, T; Mori, C; Okuno, T; Takayama, Y; Tani, T; Yabuuchi, A | 1 |
| Gurgul-Convey, E; Kaminski, MT; Lenzen, S | 1 |
| Guillemette, C; Khan, DR; Richard, FJ; Sirard, MA | 1 |
| Clauss, WG; Fronius, M; Vitzthum, C | 1 |
| Egashira, N; Kuwahara, J; Masuda, S; Ueda, M; Yamada, T; Zukeyama, N | 1 |
| Gilchrist, RB; Li, HJ; Sugimura, S; Sutton-McDowall, ML; Thompson, JG; Wang, X | 1 |
| Dibattista, M; Reisert, J | 1 |
| Balbo, SL; Bonfleur, ML; Carneiro, EM; Lubaczeuski, C; Maller, AC; Mendes, MC; Ribeiro, RA | 1 |
| Hsieh, PC; Hung, SC; Lin, SP; Wang, YL | 1 |
| Abel, T; Blackwell, KT; Gervasi, N; Girault, JA; Luczak, V | 1 |
| Hoerner, C; Korbmacher, C; Rauh, R | 1 |
| Al-Majdoub, M; Andersson, LE; Fex, M; Filipsson, K; Medina, A; Mulder, H; Nicholas, LM; Spégel, P; Sun, J | 1 |
| Larson, ED; Proenza, C; Sharpe, EJ | 1 |
| Cortese-Krott, MM; DeLalio, LJ; Diederich, L; Drake, JC; Isakson, BE; Jackson, EK; Keller, AS; Kelm, M; Panknin, C; Sherman, R; Yan, Z | 1 |
| Andric, N; Kopitovic, V; Pogrmic-Majkic, K; Samardzija, D; Stojkov-Mimic, N; Trninic-Pjevic, A; Vukosavljevic, J | 1 |
| Chimerel, C; Gribble, FM; Murison, K; Reimann, F; Riccio, C | 1 |
| Lenzen, S; Teraoku, H | 1 |
| Belaz, KRA; Castilho, ACS; Eberlin, MN; Fontes, PK; Franchi, FF; Machado, MF; Nogueira, MFG; Razza, EM; Rocha, DFO; Santos, PH; Sudano, MJ | 1 |
| Cao, Z; Li, D; Lv, P; Qi, L; Wang, W; Xu, J; Zhao, D; Zhao, G | 1 |
| Callesen, H; Fontes, PK; Hyttel, P; Kadarmideen, HN; Nogueira, MFG; Pedersen, HS; Pihl, M; Razza, EM; Stroebech, L | 1 |
| Casali, C; Chan, C; Thompson, R | 1 |
| Hashimoto, S; Inoue, M; Iwata, H; Kawahara-Miki, R; Morimoto, Y; Yamanaka, M; Yamochi, T | 1 |
| Agapiou, D; Bertoldo, MJ; Cheung, MY; Corley, SM; Gilchrist, RB; Harrison, CA; Richani, D; Sia, ZK; Wilkins, MR | 1 |
| Bertoldo, MJ; Bustamante, S; Gilchrist, RB; Kanakkaparambil, R; Lavea, CF; Richani, D; Riepsamen, AH | 1 |
| Han, Z; Hao, X; Liang, CG; Wen, X; Wu, XC; Zhao, YT; Zhou, CJ | 1 |
| Kateriya, S; Moar, P; Sushmita, K; Tandon, R | 1 |
| Alvarez, DF; Annamdevula, N; Audia, JP; Britain, A; Dunbar, G; Hardy, KS; Housley, N; Leavesley, S; Renema, P; Rich, T; Spadafora, D | 1 |
| Battaglia, D; Beck, R; Cook, NL; Foss, R; Masterson, KR; Metcalf, ES; O Leary, T; Thompson, JG | 1 |
| Carling, D; Heller, R; Langendorf, CG; Scott, JW; Spengler, K; Woods, A; Zibrova, D | 1 |
| Brehm, MA; Gallagher, KM; Green, MR; Greiner, DL; Kelliher, MA; Murphy, LC; O'Connor, KW; Roderick, JE; Tang, K; Yu, J; Zhang, B; Zhu, LJ | 1 |
| Beazley, S; Burmester, M; Campanucci, VA; Carmalt, JL; Duke, T; Fujiyama, M; Gray, B; Ianowski, JP; Jagadeeshan, S; Le, Y; Luan, X; Machen, TE; Murray, B; Shipley, A; Swekla, K; Tam, JS | 1 |
| Carvalheira, LR; Leal, GR; Monteiro, CAS; Souza-Fabjan, JMG | 1 |
| Aguiar, FLN; Azevedo, VAN; Barrozo, LG; Batista, ALPS; Costa, FC; Donato, MAM; Lopes, EPF; Nascimento, DR; Paulino, LRFM; Peixoto, CA; Rodrigues, APR; Silva, BR; Silva, JRV | 1 |
2 review(s) available for 1-methyl-3-isobutylxanthine and colforsin
| Article | Year |
|---|---|
Therapeutic potential of isozyme-selective phosphodiesterase inhibitors in the treatment of asthma.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Asthma; Colforsin; Cyclic AMP; Humans; Mast Cells; Mice; Pyrrolidinones; Rolipram | 1992 |
The Simulated Physiological Oocyte Maturation (SPOM) system in domestic animals: A systematic review.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Colforsin; Female; Follicle Stimulating Hormone; Horses; In Vitro Oocyte Maturation Techniques; Mice; Oocytes; Sheep | 2022 |
1383 other study(ies) available for 1-methyl-3-isobutylxanthine and colforsin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Relaxant response of isolated basilar arteries to calcitonin gene-related peptide in stroke-prone spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Basilar Artery; Bucladesine; Calcitonin Gene-Related Peptide; Colforsin; Hypertension; In Vitro Techniques; Isoproterenol; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1992 |
Dynamics of cyclic-AMP efflux in relation to alpha-MSH secretion from melanotrope cells of Xenopus laevis.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Amphibian Proteins; Animals; Baclofen; Calcium; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Dopamine; In Vitro Techniques; Peptide Hormones; Peptides; Pituitary Gland; Xenopus laevis | 1992 |
Regulation of expression of the chicken ovalbumin gene: interactions between steroid hormones and second messenger systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chickens; Colforsin; Corticosterone; Drug Interactions; Estrogens; Female; Gene Expression Regulation; Insulin; Ovalbumin; Oviducts; Protein Kinase C; Protein Kinases; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate | 1992 |
Calcitonin gene-related peptide stimulates intracellular cAMP via a protein kinase C-controlled mechanism in human ocular ciliary epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Calcitonin; Calcitonin Gene-Related Peptide; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Diglycerides; Epithelium; Eye; Fetus; Humans; Kinetics; Phorbol Esters; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
cAMP induces up-regulation of ETA receptor mRNA and increases responsiveness to endothelin-1 of rat aortic smooth muscle cells in primary culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Base Sequence; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Endothelins; Kinetics; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Polymerase Chain Reaction; Rats; Receptors, Endothelin; Restriction Mapping; RNA, Messenger; Up-Regulation | 1992 |
Serotonin N-acetyltransferase (NAT) induction in mammalian retina: role of cyclic AMP and calcium ions.
Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Arylamine N-Acetyltransferase; Bucladesine; Calcium; Chickens; Circadian Rhythm; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Induction; Female; Light; Male; Pineal Gland; Rabbits; Rats; Rats, Wistar; Retina; Time Factors | 1992 |
Pituitary adenylate cyclase polypeptide (PACAP) stimulates cyclic AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts: lack of enhancement by protein kinase C activation.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adenylate Cyclase Toxin; Animals; Cell Line, Transformed; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Enzyme Activation; Fibroblasts; Male; Mice; Neuropeptides; Pertussis Toxin; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland; Protein Kinase C; Rats; Rats, Wistar; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1992 |
The Na-K-Cl cotransporter of avian salt gland. Phosphorylation in response to cAMP-dependent and calcium-dependent secretogogues.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Calcium; Carbachol; Carrier Proteins; Cell Membrane; Colforsin; Cyclic AMP; Ducks; Kinetics; Membrane Proteins; Phosphates; Phosphorylation; Salt Gland; Sodium-Potassium-Chloride Symporters; Time Factors; Vasoactive Intestinal Peptide | 1992 |
Inhibition of proliferation, but not of Ca2+ mobilization, by cyclic AMP and GMP in rabbit aortic smooth-muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Aorta; Calcium; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Muscle, Smooth; Platelet-Derived Growth Factor; Rabbits; Serotonin | 1992 |
Dopaminergic modulation of gap junction permeability between amacrine cells in mammalian retina.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Benzazepines; Bicuculline; Cadmium; Cadmium Chloride; Cell Membrane Permeability; Chlorides; Colforsin; Dopamine; Ergolines; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Intercellular Junctions; Male; Quinpirole; Rabbits; Retina; Synapses; Veratridine | 1992 |
Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzazepines; Calcium; Calcium Channels; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Dopamine; Enzyme Activation; GTP-Binding Proteins; Humans; Inositol Phosphates; Ion Channel Gating; L Cells; Mice; Nifedipine; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Pituitary Gland; Protein Kinases; Rats; Receptors, Dopamine; Signal Transduction; Spiperone; Sulpiride; Virulence Factors, Bordetella | 1992 |
cAMP-mediated second messenger mechanisms are involved in spinule formation in teleost cone horizontal cells.
Topics: 1-Methyl-3-isobutylxanthine; Adaptation, Ocular; Animals; Bucladesine; Colforsin; Cyclic AMP; Dopamine; Fishes; Microscopy, Electron; Neural Pathways; Photoreceptor Cells; Receptors, Dopamine D1; Second Messenger Systems | 1992 |
Histamine-induced depolarization and the cyclic AMP--protein kinase A system in isolated guinea pig adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Alprostadil; Animals; Carbazoles; Colforsin; Cyclic AMP; Electrophysiology; Epididymis; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Insulin; Isoproterenol; Male; Membrane Potentials; Protein Kinase C; Protein Kinases; Pyrroles; Rats; Rats, Wistar | 1992 |
Effects of nerve growth factor and acetyl-L-carnitine arginyl amide on the human neuronal line HCN-1A.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcarnitine; Animals; Arginine; Brain Chemistry; Cell Differentiation; Cell Line; Colforsin; gamma-Aminobutyric Acid; Humans; Immunohistochemistry; Mice; Nerve Growth Factors; Neurofilament Proteins; Neurons | 1992 |
Role of cyclic AMP in prostaglandin-induced modulation of acetylcholine release from the myenteric plexus of guinea pig ileum.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Colforsin; Cyclic AMP; Dinoprostone; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth; Myenteric Plexus; Nicotine; Prostaglandins | 1992 |
Bradykinin inhibition of cyclic AMP accumulation in D384 astrocytoma cells. Evidence against a role of cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Arginine; Astrocytoma; Bradykinin; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Hydroxylamine; Hydroxylamines; Kinetics; NG-Nitroarginine Methyl Ester; Nitroprusside; Pyrrolidinones; Rolipram; Tumor Cells, Cultured | 1992 |
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Insulin; Insulin Secretion; Insulinoma; Membrane Potentials; Mercaptoethanol; Pancreatic Neoplasms; Rats; Tumor Cells, Cultured | 1992 |
Biphasic effect of cAMP-elevating agents on ICAM-1 expression stimulated by retinoic acid and interferon gamma.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Adhesion Molecules; Cholera Toxin; Colforsin; Cyclic AMP; Cytosol; Gene Expression Regulation, Neoplastic; Glioma; Guanosine Triphosphate; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Kinetics; Pertussis Toxin; Recombinant Proteins; Stimulation, Chemical; Time Factors; Tretinoin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
cAMP and Ca(2+)-mediated secretion in parotid acinar cells is associated with reversible changes in the organization of the cytoskeleton.
Topics: 1-Methyl-3-isobutylxanthine; Actins; alpha-Amylases; Animals; Biomarkers; Bucladesine; Calcium; Calcium Chloride; Carbachol; Carrier Proteins; Cells, Cultured; Colforsin; Cyclic AMP; Cytoskeleton; Egtazic Acid; Guinea Pigs; Isoproterenol; Male; Microfilament Proteins; Parotid Gland | 1992 |
Catecholamines modulate epidermal growth factor-induced prostaglandin E2 production in amnion-like (WISH) cells by means of a cyclic adenosine monophosphate-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Amnion; Catecholamines; Cell Line; Colforsin; Cyclic AMP; Dinoprostone; Dopamine; Epidermal Growth Factor; Epinephrine; Female; Humans; Norepinephrine; Propranolol | 1992 |
cAMP-activated chloride conductance in the colonic cell line, Caco-2.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cell Line; Chloride Channels; Chlorides; Colforsin; Colon; Cyclic AMP; Electric Conductivity; Iodine; Iodine Radioisotopes; Membrane Proteins; Stimulation, Chemical | 1992 |
Forskolin and phorbol ester stimulation of neuropeptide Y (NPY) production and secretion by aggregating fetal brain cells in culture: evidence for regulation of NPY biosynthesis at transcriptional and posttranscriptional levels.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Aggregation; Cells, Cultured; Colforsin; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Fetus; Hypothalamus; Kinetics; Neuropeptide Y; Olfactory Bulb; Protein Biosynthesis; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Transcription, Genetic; Verapamil | 1992 |
Mechanisms of insulin inhibition of ACTH-stimulated steroid secretion by cultured bovine adrenocortical cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Cortex; Adrenocorticotropic Hormone; Androstenedione; Angiotensin II; Animals; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Hydrocortisone; Insulin; Kinetics; Thionucleotides | 1992 |
Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3).
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Binding Sites; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Glucagon-Like Peptides; Insulinoma; Iodine Radioisotopes; Oxyntomodulin; Rats; Somatostatin; Tumor Cells, Cultured | 1992 |
Vasoactive intestinal peptide and forskolin regulate proliferation of the HT29 human colon adenocarcinoma cell line.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Blood; Cell Division; Colforsin; Colonic Neoplasms; Cyclic AMP; Humans; Insulin; Interphase; Kinetics; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1992 |
Zinc-induced molt: evidence for a direct inhibitory effect on granulosa cell steroidogenesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Eating; Feathers; Female; Follicle Stimulating Hormone; Granulosa Cells; Luteinizing Hormone; Progesterone; Sulfates; Zinc; Zinc Sulfate | 1992 |
Effect of adenosine analogues and cAMP-raising agents on TNF-, GM-CSF-, and chemotactic peptide-induced degranulation in single adherent neutrophils.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Blood Proteins; Bucladesine; Cell Adhesion; Cell Degranulation; Chemotactic Factors; Colforsin; Cyclic AMP; Cytochalasin B; Exocytosis; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1992 |
Cyclic AMP metabolism in fragile X syndrome.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Alprostadil; Blood Platelets; Child; Child, Preschool; Colforsin; Cyclic AMP; Female; Fragile X Syndrome; Humans; Intellectual Disability; Learning; Male; Memory, Short-Term; Middle Aged; Second Messenger Systems | 1992 |
Differential regulation of the imipramine-sensitive serotonin transporter by cAMP in human JAr choriocarcinoma cells, rat PC12 pheochromocytoma cells, and C33-14-B1 transgenic mouse fibroblast cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cells, Cultured; Cholera Toxin; Choriocarcinoma; Colforsin; Cyclic AMP; Fibroblasts; Humans; Imipramine; Mice; Mice, Transgenic; PC12 Cells; Rats; Serotonin | 1992 |
Cyclic-AMP-dependent positive chrono- and inotropic responses in the blood-perfused dog atrium.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Colforsin; Depression, Chemical; Dogs; Heart Atria; Heart Rate; In Vitro Techniques; Myocardial Contraction; Norepinephrine; Perfusion; Stimulation, Chemical | 1992 |
Asymmetric modulation of cytosolic cAMP activity induces growth cone turning.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Cytosol; Nervous System; Neurites; Xenopus | 1992 |
Cyclic AMP-independent secretion of mucin by SW1116 human colon carcinoma cells. Differential control by Ca2+ ionophore A23187 and arachidonic acid.
Topics: 1-Methyl-3-isobutylxanthine; Arachidonic Acid; Calcimycin; Cell Line; Colforsin; Colonic Neoplasms; Cyclic AMP; Glucuronidase; Humans; Kinetics; Mucins | 1992 |
Prostacyclin analogues inhibit tissue factor expression in the human monocytic cell line THP-1 via a cyclic AMP-dependent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Colforsin; Cyclic AMP; Endotoxins; Epoprostenol; Fluorescent Antibody Technique; Humans; Iloprost; Interleukin-1; Monocytes; Prostaglandins, Synthetic; Thromboplastin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1992 |
Regulation of progesterone secretion in human syncytiotrophoblast in culture by human chorionic gonadotropin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Colforsin; Culture Techniques; Cyclic AMP; Humans; Lipoproteins, LDL; Mitochondria; Progesterone; Secretory Rate; Trophoblasts | 1992 |
Prostaglandin E1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Cell Line; Colforsin; Cyclic AMP; Dinoprost; Dinoprostone; Fibroblasts; Gene Expression; Humans; Microbial Collagenase; Promoter Regions, Genetic; Rabbits; RNA, Messenger; Synovial Membrane | 1992 |
Effect of 3-isobutyl-1-methylxanthine and zaprinast on non-adrenergic non-cholinergic relaxation in the rat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Colforsin; Drug Interactions; Electric Stimulation; Female; Gastric Fundus; Male; Muscle Relaxation; Purinones; Rats; Rats, Inbred Strains | 1992 |
Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones.
Topics: 1-Methyl-3-isobutylxanthine; Albumins; Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Epidermal Growth Factor; Fetus; Gene Expression Regulation; Glucagon; Liver; Norepinephrine; Phorbol Esters; Rats; Rats, Inbred Strains; RNA, Messenger; Signal Transduction; Time Factors; Vasopressins | 1992 |
Limited accumulation of cyclic AMP underlies a modest vasoactive-intestinal-peptide-mediated increase in cytosolic [Ca2+] transients in GH3 pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Cell Line; Colforsin; Cyclic AMP; Cytosol; Kinetics; Pituitary Neoplasms; Rats; Thionucleotides; Time Factors; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1992 |
Endothelin modulation of tissue plasminogen activator release from human vascular endothelial cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Calcimycin; Calcium; Cells, Cultured; Colforsin; Egtazic Acid; Endothelins; Endothelium, Vascular; Fibrinolysis; Humans; L-Lactate Dehydrogenase; Tissue Plasminogen Activator | 1992 |
The expression of 80K/MARCKS, a major substrate of protein kinase C (PKC), is down-regulated through both PKC-dependent and -independent pathways. Effects of bombesin, platelet-derived growth factor, and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Blotting, Northern; Bombesin; Cell Nucleus; Colforsin; Cyclic AMP; Enzyme Activation; Homeostasis; Insulin; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phorbol 12,13-Dibutyrate; Platelet-Derived Growth Factor; Protein Kinase C; Proteins; RNA, Messenger; Time Factors; Transcription, Genetic | 1992 |
Involvement of cyclic adenosine monophosphate in the stimulation of gonadotropin secretion from the pituitary of the teleost fish, tilapia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Female; Fishes; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Kinetics; Perfusion; Pituitary Gland | 1992 |
Modulation of synaptic efficacy in field CA1 of the rat hippocampus by forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Drug Synergism; Enzyme Activation; Hippocampus; Male; Protein Kinases; Rats; Rats, Inbred Strains; Synapses | 1992 |
In vitro evidence for modulation of morphological and functional development of hypothalamic immunoreactive atrial natriuretic peptide neurons by cyclic 3',5'-adenosine monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Atrial Natriuretic Factor; Cell Count; Colforsin; Colorimetry; Fluorescent Antibody Technique; Hypothalamus; Neurons; Oligonucleotide Probes; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Tetradecanoylphorbol Acetate | 1992 |
[Damage to human endothelial cells by cholestane-3 beta,5 alpha,6 beta-triol and the protective effects of preparations that raise the intracellular level of cAMP].
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adult; Aorta, Thoracic; Arteriosclerosis; Cell Survival; Cells, Cultured; Cholestanols; Colforsin; Cyclic AMP; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Humans; Middle Aged; Time Factors | 1992 |
Discontinuous and continuous stimulation of FRTL-5 thyroid cells with bTSH cause different cAMP and nuclear proliferation antigen responses.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies, Monoclonal; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Immunoenzyme Techniques; Kinetics; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Rats; Thyroid Gland; Thyrotropin | 1992 |
Effect of albumin on adenylate cyclase receptor-related signal transduction of human peripheral blood mononuclear cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Colforsin; Cyclic AMP; Drug Interactions; Enzyme Activation; Histamine; Humans; Hydrogen-Ion Concentration; Isoproterenol; Monocytes; Serum Albumin; Signal Transduction | 1992 |
Modulation of potassium channels in intact human T lymphocytes.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Calcium; Colforsin; Cyclic AMP; Cytoplasm; Dinoprostone; Electric Stimulation; Histamine; Humans; Isoproterenol; Potassium Channels; T-Lymphocytes; Temperature | 1992 |
Agents that affect calcium influx can change cyclic nucleotide levels in cultured chick pineal cells.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Egtazic Acid; Kinetics; Nitrendipine; Pineal Gland | 1992 |
CCK mRNA expression, pro-CCK processing, and regulated secretion of immunoreactive CCK peptides by rat insulinoma (RIN 5F) and mouse pituitary tumor (AtT-20) cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cholecystokinin; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Gene Expression; Insulinoma; Mice; Pancreatic Neoplasms; Pituitary Neoplasms; Protein Precursors; Rats; RNA, Messenger; Sincalide; Tumor Cells, Cultured | 1992 |
Human immunodeficiency virus replication: modulation by cellular levels of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; HIV-1; Kinetics; Monocytes; Phosphodiesterase Inhibitors; T-Lymphocytes; Tumor Cells, Cultured; Virus Replication | 1992 |
Role of cyclic nucleotides and calcium in the nutrient-induced release of cholecystokinin-like immunoreactivity in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Channels; Cholecystokinin; Colforsin; Dose-Response Relationship, Drug; Duodenum; Jejunum; Nucleotides, Cyclic; Radioimmunoassay; Rats; Receptors, Cholecystokinin; Tetradecanoylphorbol Acetate | 1992 |
Relationship between cyclic AMP-stimulated and native gonadotropin-releasing hormone-stimulated gonadotropin release in the goldfish.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine Agents; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins; Kinetics; Nerve Endings | 1992 |
Beta-adrenergic regulation of a myocardial actin gene via a cyclic AMP-independent pathway.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Actins; Animals; Animals, Newborn; Blotting, Northern; Bucladesine; Caffeine; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Enkephalins; Gene Expression Regulation; Heart; Heart Ventricles; Isoproterenol; Kinetics; Myocardium; Nifedipine; Potassium Chloride; Propranolol; Protein Precursors; Rats; Receptors, Adrenergic, beta; RNA; RNA, Messenger; Ryanodine | 1992 |
Astroglial membrane structure is affected by agents that raise cyclic AMP and by phosphatidylcholine phospholipase C.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Astrocytes; Cattle; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Freeze Fracturing; Glioma; Guinea Pigs; Immunohistochemistry; Isoproterenol; Lectins; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Protein Kinases; Rats; Retina; Second Messenger Systems; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1992 |
Cyclic nucleotides mediate an odor-evoked potassium conductance in lobster olfactory receptor cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Electric Conductivity; Nephropidae; Odorants; Olfactory Pathways; Potassium; Signal Transduction | 1992 |
Positively cooperative cAMP phosphodiesterase attenuates cellular cAMP responses.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Epinephrine; Tumor Cells, Cultured | 1992 |
Role of cAMP in the functional interaction of carbachol with different cAMP elevating agents in rabbit atrium.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Analysis of Variance; Animals; Carbachol; Colforsin; Cyclic AMP; Depression, Chemical; Female; Heart Atria; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Pertussis Toxin; Rabbits; Virulence Factors, Bordetella | 1992 |
Role of cyclic AMP in the release of noradrenaline from isolated rat atria. Effect of pretreatment with clenbuterol.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Clenbuterol; Colforsin; Cyclic AMP; Electric Stimulation; Heart; In Vitro Techniques; Myocardium; Norepinephrine; Rats; Rats, Wistar; Yohimbine | 1992 |
Control of cyclic AMP levels in primary cultures of human tracheal smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Carbachol; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Humans; Isoproterenol; Muscle, Smooth; Phosphodiesterase Inhibitors; Propanolamines; Trachea | 1992 |
Effect of cAMP elevating compounds on inhibition of gap junctional communication and induction of morphological transformation in Syrian hamster embryo cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Communication; Cell Transformation, Neoplastic; Cells, Cultured; Cholera Toxin; Colforsin; Cricetinae; Cyclic AMP; Embryo, Mammalian; Intercellular Junctions; Mesocricetus; Tetradecanoylphorbol Acetate; Theophylline | 1992 |
Modulation of growth-related gene expression and growth inhibition by cyclic adenosine 3',5'-monophosphate-elevating agents in the insulin-producing cell line beta TC1.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Polyomavirus Transforming; Cell Cycle; Cell Division; Cell Line; Colforsin; Cyclic AMP; Gene Expression; Genes, fos; Genes, jun; Insulin; Islets of Langerhans; Mice; RNA, Messenger | 1992 |
Platelet-derived growth factor-stimulated c-myc RNA accumulation in MG-63 human osteosarcoma cells is independent of both protein kinase A and protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation; Humans; Osteosarcoma; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; RNA, Messenger; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1990 |
Histidine regulation of cyclic AMP metabolism in cultured renal epithelial LLC-PK1 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Arginine Vasopressin; Aspartic Acid; Cells, Cultured; Colforsin; Cyclic AMP; Epithelial Cells; Epithelium; Glutamates; Glutamic Acid; Histidine; Imidazoles; Indomethacin; Kidney; Swine | 1990 |
Evidence that adenosine 3',5'-monophosphate mediates hormonal stimulation of prostaglandin production in cultured mouse parietal bones.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Bone and Bones; Colforsin; Cyclic AMP; Dinoprostone; Hydrocortisone; Kinetics; Mice; Organ Culture Techniques; Parathyroid Hormone | 1990 |
Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetyl-CoA Carboxylase; Adipose Tissue; Amino Acid Sequence; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Epinephrine; Isoproterenol; Kinetics; Ligases; Molecular Sequence Data; Phosphorylation; Protein Kinases; Rats; Serine | 1990 |
Response of the rat tail artery to prolonged exposure to noradrenaline.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Colforsin; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Rats; Regional Blood Flow; Tail; Temperature | 1990 |
Increase in membrane fluidity modulates sodium-coupled uptakes and cyclic AMP synthesis by renal proximal tubular cells in primary culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzyl Alcohols; Cattle; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Kidney Tubules, Proximal; Kinetics; Membrane Fluidity; Parathyroid Hormone; Rabbits; Sodium | 1990 |
Protein kinase C activators sensitize cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Astrocytoma; Carbachol; Colforsin; Cyclic AMP; Down-Regulation; Enzyme Activation; Humans; Isoproterenol; Pertussis Toxin; Phosphatidylinositols; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1990 |
The identification and characterization of an uptake system for taurine into rat lung slices.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Antimycin A; Binding, Competitive; Bucladesine; Chloroquine; Chlorpromazine; Colforsin; Diamide; Kinetics; Lung; Male; Potassium Cyanide; Rats; Rats, Inbred Strains; Sodium; Taurine | 1990 |
Group II phospholipase A2 mRNA synthesis is stimulated by two distinct mechanisms in rat vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Dactinomycin; Drug Synergism; Gene Expression; Interleukin-1; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; Phospholipases; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; RNA, Messenger; Tumor Necrosis Factor-alpha; Vasculitis | 1990 |
Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Caffeine; Cerebral Cortex; Colforsin; Cyclic AMP; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1990 |
Supersensitivity and changes in the active population of beta adrenoceptors in rat right atria in early sepsis.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Atrial Function; Colforsin; Dose-Response Relationship, Drug; GTP-Binding Proteins; Heart Rate; Male; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Sepsis | 1990 |
Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Gland Neoplasms; Animals; Bucladesine; Cell Differentiation; Cell Line; Colforsin; Cyclic CMP; Dibutyryl Cyclic GMP; Dimethyl Sulfoxide; Electric Conductivity; Electrophysiology; Gene Expression; Genes, ras; Kinetics; Nerve Growth Factors; Pheochromocytoma; Protein Kinases; Rats; Sodium Channels; Tetrodotoxin | 1990 |
Subtype-specific cyclic AMP-dependent histone H1 phosphorylation at the differentiation of mouse neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Histones; Mice; Neuroblastoma; Peptide Mapping; Phosphates; Phosphopeptides; Phosphorylation; Theophylline; Tumor Cells, Cultured; Tyrosine | 1990 |
Adenosine receptor-mediated accumulation of cyclic AMP-induced T-lymphocyte death through internucleosomal DNA cleavage.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bucladesine; Cell Survival; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Kinetics; Male; Mice; Mice, Inbred BALB C; Phenylisopropyladenosine; Receptors, Purinergic; T-Lymphocytes | 1990 |
Effects of pimobendan, a cardiotonic and vasodilating agent with phosphodiesterase inhibiting properties, on isolated arteries and veins of rats.
Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Arteries; Cardiotonic Agents; Colforsin; Drug Interactions; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyridazines; Rats; Rats, Inbred Strains; Vasodilator Agents; Veins | 1990 |
Multiple hormone actions: the rises in cAMP and Ca++ in MDCK-cells treated with glucagon and prostaglandin E1 are independent processes.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Calcium; Carbachol; Cell Line; Colforsin; Cyclic AMP; Dogs; Fluorescent Dyes; Glucagon; Indoles; Isoproterenol; Kidney; Kinetics; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1990 |
Modulation of carbachol-induced inositol phosphate formation in bovine tracheal smooth muscle by cyclic AMP phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Albuterol; Animals; Calcium; Carbachol; Cattle; Colforsin; Cyclic AMP; Drug Interactions; In Vitro Techniques; Inositol Phosphates; Male; Membrane Lipids; Muscle, Smooth; Phospholipids; Purinones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1990 |
Distinct effects of calcium- and cyclic AMP-enhancing factors on cytoskeletal synthesis and assembly in mouse osteoblastic cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Alkaline Phosphatase; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytoskeletal Proteins; DNA Replication; Kinetics; Mice; Osteoblasts; Parathyroid Hormone; Theophylline; Tubulin; Vimentin | 1990 |
Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Cell Line; Colforsin; Cyclic AMP; Eicosanoids; Kinetics; Leukotrienes; Mast Cells; Mice; Platelet Activating Factor; Prostaglandin D2; Theophylline | 1990 |
Phospholipase C activity in NCB-20 cells is inhibited by protein kinase A-mediated phosphorylation of low molecular mass GTP-binding proteins.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Brain; Cell Line; Cholera Toxin; Colforsin; Cricetinae; Embryo, Mammalian; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hybrid Cells; Inositol Phosphates; Kinetics; Molecular Weight; Neuroblastoma; Phosphorylation; Protein Kinases; Thionucleotides; Type C Phospholipases | 1990 |
Cyclic AMP regulates an inward rectifying sodium-potassium current in dissociated bull-frog sympathetic neurones.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Membrane Potentials; Neurons; Potassium; Rana catesbeiana; Sodium; Sympathetic Nervous System; Thionucleotides; Time Factors | 1990 |
Forskolin-induced desensitization of pancreatic beta-cell insulin secretory responsiveness: possible involvement of impaired information flow in the inositol-lipid cycle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Diacylglycerol Kinase; Diglycerides; Glucose; Glycerides; Inositol; Insulin; Insulin Secretion; Islets of Langerhans; Male; Phosphatidylinositols; Phosphotransferases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
Proliferation of bovine undifferentiated mammary epithelial cells in vitro is modulated by G-proteins.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Blood; Cattle; Cell Division; Cholera Toxin; Colforsin; Cyclic AMP; DNA; Drug Synergism; Epidermal Growth Factor; Epithelial Cells; Female; GTP-Binding Proteins; Insulin; Insulin-Like Growth Factor I; Mammary Glands, Animal; Pertussis Toxin; Virulence Factors, Bordetella | 1990 |
Potentiation of norepinephrine secretion by angiotensin II in the isolate rabbit iris-ciliary body.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Calcimycin; Ciliary Body; Colforsin; Electric Stimulation; In Vitro Techniques; Iris; Male; Norepinephrine; Rabbits; Saralasin; Tetrodotoxin | 1990 |
Guanine nucleotide-dependent inhibition of phospholipase C in human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Aluminum; Aluminum Chloride; Aluminum Compounds; Calcimycin; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Deoxycholic Acid; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Inositol Phosphates; Kinetics; Sodium Fluoride; Thionucleotides; Thrombin; Type C Phospholipases; Umbilical Veins | 1990 |
Regulation of the expression of the regulatory subunit of cAMP-dependent protein kinase II beta in Friend erythroleukemic cells. Evidence for posttranscriptional control and a central role for the C subunit.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; DNA; Friend murine leukemia virus; Gene Expression Regulation; Half-Life; Kinetics; Leukemia, Erythroblastic, Acute; Macromolecular Substances; Molecular Sequence Data; Oligopeptides; Protein Kinases; RNA Precursors; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transfection | 1990 |
cAMP-activated chloride channel in the basolateral membrane of the thick ascending limb of the mouse kidney.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Basement Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Electric Conductivity; In Vitro Techniques; Kidney Tubules; Loop of Henle; Male; Membrane Potentials; Membrane Proteins; Mice | 1990 |
Agents which increase cyclic AMP have diverse effects on low-density-lipoprotein-receptor function in human vascular smooth-muscle cells and skin fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Fibroblasts; Humans; Kinetics; Lipoproteins, LDL; Muscle, Smooth, Vascular; Receptors, LDL; Skin | 1990 |
Effects of forskolin and 1,9-dideoxy-forskolin on cochlear potentials.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cochlear Microphonic Potentials; Colforsin; Evoked Potentials, Auditory; Guinea Pigs | 1990 |
1,25-dihydroxyvitamin D3 and agents that increase intracellular adenosine 3',5'-monophosphate synergistically inhibit the mitogenic stimulation of human lymphocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Monophosphate; Binding Sites; Calcitriol; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dinoprostone; Drug Synergism; Histamine; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes | 1990 |
Chloride permeability regulation via a cyclic AMP pathway in cultured human sweat duct cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Cell Membrane Permeability; Cells, Cultured; Chlorides; Cholera Toxin; Colforsin; Cyclic AMP; Cystic Fibrosis; Dinoprostone; Humans; Membrane Potentials; Sweat Glands | 1990 |
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Animals; Carbachol; Colforsin; Cyclic AMP; Drug Synergism; Glipizide; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Potassium; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Intracellular coupling of prostaglandin inhibition of acid secretion in isolated rabbit gastric parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Aminopyrine; Animals; Anti-Ulcer Agents; Carbachol; Cells, Cultured; Colforsin; Cyclic AMP; Gastric Acid; Histamine Antagonists; Inositol Phosphates; Misoprostol; Parietal Cells, Gastric; Rabbits; Theophylline | 1990 |
Propranolol inhibits cyclic AMP accumulation and amylase secretion in parotid acinar cells stimulated by isobutylmethylxanthine and forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Alprenolol; Amylases; Animals; Atenolol; Butoxamine; Colforsin; Cyclic AMP; Male; Membrane Proteins; Parotid Gland; Poly(ADP-ribose) Polymerases; Propranolol; Rats; Rats, Inbred Strains; Saponins; Theophylline | 1990 |
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Cholera Toxin; Colforsin; Cyclic AMP; Diglycerides; Epidermal Growth Factor; ErbB Receptors; Glycerides; Humans; Kinetics; Peptide Mapping; Phosphopeptides; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Axons; Bucladesine; Calcimycin; Cell Cycle; Cell Transformation, Neoplastic; Colforsin; Cyclic AMP; Fibroblasts; Humans; Hybrid Cells; Methylcellulose; Neuroblastoma; Neurons; Phenotype; Rats; Thymidine; Tretinoin; Tumor Cells, Cultured | 1990 |
Synthesis and secretion of somatostatin-28 and -14 by fetal rat intestinal cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Bucladesine; Butyrates; Butyric Acid; Cells, Cultured; Chromatography, Gel; Colforsin; Ethanol; Fetus; Fluorescent Antibody Technique; Intestinal Mucosa; Intestines; Protein Precursors; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Somatostatin; Somatostatin-28; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1990 |
AVP reduces transepithelial resistance across IMCD cell monolayers.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Amiloride; Animals; Arginine Vasopressin; Benzofurans; Biomechanical Phenomena; Cells, Cultured; Colforsin; Cyclic AMP; Electric Conductivity; Epithelium; Fluorescent Dyes; Fura-2; Ionomycin; Kidney Medulla; Kidney Tubules; Kidney Tubules, Collecting; Trypsin | 1990 |
Antigonadotropic and antisteroidogenic actions of peroxide in rat granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Animals; Benzamides; Cholera Toxin; Colforsin; Cyclic AMP; DNA Repair; Female; Follicle Stimulating Hormone; Free Radicals; Granulosa Cells; Hydrogen Peroxide; Luteinizing Hormone; Oxygen; Progesterone; Rats | 1990 |
Opioid inhibition of cholinergic transmission in the guinea-pig ileum is independent of intracellular cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Carbachol; Cholera Toxin; Colforsin; Cyclic AMP; Dynorphins; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Narcotics; Parasympathetic Nervous System; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Transmission | 1990 |
Interleukin 1 interacts synergistically with forskolin and isobutylmethylxanthine in stimulating bone resorption in organ culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone and Bones; Bone Resorption; Colforsin; Drug Synergism; Interleukin-1; Organ Culture Techniques; Osteoblasts; Osteoclasts; Rats; Theophylline | 1990 |
Cyclic AMP-dependent induction of serotonin N-acetyltransferase activity in photoreceptor-enriched chick retinal cell cultures: characterization and inhibition by dopamine.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Dopamine; Dopamine Antagonists; Enzyme Induction; Kainic Acid; Photoreceptor Cells; Receptors, Dopamine; Receptors, Dopamine D2; Retina; Time Factors | 1990 |
Effects of GTP, forskolin, sodium fluoride, serotonin, dopamine, and carbachol on adenylate cyclase in Teleost retina.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Atropine; Carbachol; Colforsin; Cyclic AMP; Dopamine; Drug Synergism; Fishes; GTP-Binding Proteins; Guanosine Triphosphate; Pertussis Toxin; Retina; Serotonin; Sodium Fluoride; Tetrahydronaphthalenes; Virulence Factors, Bordetella | 1990 |
Activation of PKC inhibits NaF-induced inositol phospholipid turnover in rat insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Protein Kinase C; Rats; Sodium Fluoride; Tumor Cells, Cultured | 1990 |
Cyclic AMP response to recombinant human relaxin by cultured human endometrial cells--a specific and high throughput in vitro bioassay.
Topics: 1-Methyl-3-isobutylxanthine; Biological Assay; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprost; Dinoprostone; Endometrium; Female; Humans; Recombinant Proteins; Relaxin | 1990 |
Regulation of maxi-K+ channels on pancreatic duct cells by cyclic AMP-dependent phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Barium; Bucladesine; Calcium; Catalysis; Colforsin; In Vitro Techniques; Membrane Potentials; Pancreatic Ducts; Phosphorylation; Potassium Channels; Protein Kinases; Rats; Secretin | 1990 |
Epidermal growth factor potentiates cyclic AMP accumulation in A-431 cells.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Squamous Cell; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Drug Synergism; Epidermal Growth Factor; Humans; Isoproterenol; Kinetics; Tumor Cells, Cultured | 1990 |
Testosterone treatment of ovariectomized rats: effects on lipolysis regulation in adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Bucladesine; Colforsin; Cyclic AMP; Epinephrine; Female; Isoproterenol; Lipolysis; Norepinephrine; Ovariectomy; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Testosterone | 1990 |
The effect of chronic fatty acid treatment on lipolysis in 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Bucladesine; Cell Line; Colforsin; Dose-Response Relationship, Drug; Fatty Acids; In Vitro Techniques; Lipid Mobilization; Mice; Oleic Acid; Oleic Acids | 1990 |
Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Fetus; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Isoproterenol; Kinetics; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Rats; Rats, Inbred Strains; Somatomedins; Teriparatide; Theophylline; Transcription, Genetic | 1990 |
Adipose conversion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor I, corticosterone, and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Bucladesine; Cell Differentiation; Cell Line; Colforsin; Corticosterone; Culture Media; Cyclic AMP; DNA Replication; Epidermal Growth Factor; Insulin-Like Growth Factor I; Kinetics; Mice; Somatomedins; Theophylline | 1990 |
The spatial distribution of exposed nuclear DNA in normal, cancer, and reverse-transformed cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Chromatin; Colforsin; Cyclic AMP; DNA; DNA, Neoplasm; Phenotype | 1990 |
Bidirectional regulation of cAMP generating system by dopamine-D1 and D2-receptors in the rat retina.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzazepines; Colforsin; Cyclic AMP; Ergolines; In Vitro Techniques; Male; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Retina | 1990 |
17 beta-estradiol depolarization of hypothalamic neurons is mediated by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Colforsin; Cyclic AMP; Cyclic GMP; Drug Implants; Electric Conductivity; Estradiol; Female; Guinea Pigs; Hypothalamus; Imidazoles; Membrane Potentials; Neurons; Ovariectomy; Potassium; Theophylline | 1990 |
Effects of different types of stimulation on cyclic AMP content in the rabbit carotid body: functional significance.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carbon Dioxide; Carotid Body; Colforsin; Cyanides; Cyclic AMP; In Vitro Techniques; Kinetics; Potassium; Rabbits | 1990 |
Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Morphine; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Theophylline; Vasoactive Intestinal Peptide | 1990 |
Alpha-MSH causes a small rise in cAMP but has no effect on basal or ultraviolet-stimulated melanogenesis in human melanocytes.
Topics: 1-Methyl-3-isobutylxanthine; Child; Child, Preschool; Colforsin; Cyclic AMP; Humans; Male; Melanins; Melanocyte-Stimulating Hormones; Melanocytes; Melanoma; Skin Neoplasms; Time Factors; Ultraviolet Rays | 1990 |
The effect of forskolin on the response of acetylcholine receptors in frog sartorius endplate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Membrane Potentials; Motor Endplate; Neuromuscular Junction; Rana esculenta; Receptors, Cholinergic | 1990 |
Elevation of angiotensin converting enzyme in bovine endothelial cells quantitated by an ELISA.
Topics: 1-Methyl-3-isobutylxanthine; Aldosterone; Animals; Bucladesine; Calcimycin; Cattle; Cells, Cultured; Colforsin; Dexamethasone; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Kinetics; Peptidyl-Dipeptidase A; Triiodothyronine | 1990 |
Hyperpolarization of myenteric neurons by opioids does not involve cyclic adenosine-3',5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Neurons | 1990 |
Cl- channel blockers inhibit acid secretion in rabbit parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anthracenes; Atropine; Carbachol; Chloride Channels; Cimetidine; Colforsin; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Ion Channels; Kinetics; Membrane Proteins; ortho-Aminobenzoates; Rabbits | 1990 |
Hormonally regulated proteins in cultured human fetal lung: analysis by two-dimensional gel electrophoresis.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Dexamethasone; Electrophoresis, Gel, Two-Dimensional; Fetus; Fibroblasts; Humans; Interferon-gamma; Lung; Organ Culture Techniques; Protein Biosynthesis; Proteins; Recombinant Proteins; Transforming Growth Factor beta; Triiodothyronine | 1990 |
Iron inhibits D-1 dopamine receptor coupled adenylate cyclase via G-proteins in the caudate nucleus of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Caudate Nucleus; Cholera Toxin; Colforsin; Dopamine; Female; Ferrous Compounds; GTP-Binding Proteins; Guanine Nucleotides; Kinetics; Papaverine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Virulence Factors, Bordetella | 1990 |
Evidence for post-translational processing of auriculin B to atriopeptin III immediately prior to secretion by hypothalamic neurons in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Colforsin; Dose-Response Relationship, Drug; Hypothalamus; Neurons; Peptide Fragments; Protein Processing, Post-Translational | 1990 |
Tumor necrosis factor and CD11/CD18 (beta 2) integrins act synergistically to lower cAMP in human neutrophils.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Actin Cytoskeleton; Actins; Antigens, Differentiation; Blood Proteins; Bucladesine; CD11 Antigens; CD18 Antigens; Cell Adhesion; Cell Movement; Colforsin; Cyclic AMP; Humans; Hydrogen Peroxide; Integrins; Kinetics; Neutrophils; Oxygen; Plastics; Receptors, Leukocyte-Adhesion; Tumor Necrosis Factor-alpha | 1990 |
Involvement of cyclic AMP in multiple, excitatory actions of biogenic amines on the cardiac ganglion of the horseshoe crab Limulus polyphemus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biogenic Amines; Colforsin; Cyclic AMP; Dopamine; Electrophysiology; Epinephrine; Heart; Horseshoe Crabs; Kinetics; Nervous System; Nervous System Physiological Phenomena; Norepinephrine; Octopamine | 1990 |
Regulation of cAMP metabolism in mouse parotid gland by cGMP and calcium.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Calcium; Carbachol; Colforsin; Cyclic AMP; Cyclic GMP; Hydroxylamine; Hydroxylamines; Mice; Parotid Gland | 1990 |
Xenopus oocyte K+ current. III. Phorbol esters and pH regulate current at gap junctions.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Cyclic AMP; Female; Follicle Stimulating Hormone; Hydrogen-Ion Concentration; Intercellular Junctions; Isoproterenol; Kinetics; Mathematics; Models, Biological; Oocytes; Phorbol 12,13-Dibutyrate; Potassium Channels; Xenopus laevis | 1990 |
cAMP mediates the increase in apical membrane Na+ conductance produced in rat CCD by vasopressin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Bucladesine; Cell Membrane; Colforsin; Cyclic AMP; Electric Conductivity; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Collecting; Male; Rats; Rats, Inbred Strains; Sodium | 1990 |
Modulation of the constitutive gene expression of the 55 kD tumor necrosis factor receptor in hematopoietic cells.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carcinoma, Hepatocellular; Colforsin; Gene Expression Regulation; Humans; Leukemia, Promyelocytic, Acute; Leukocytes, Mononuclear; Liver Neoplasms; Molecular Weight; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Reference Values; RNA; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1990 |
Modulation of glucose-induced insulin secretion from a rat clonal beta-cell line.
Topics: 1-Methyl-3-isobutylxanthine; Alanine; Animals; Carbachol; Cell Line; Clone Cells; Clonidine; Colforsin; Dose-Response Relationship, Drug; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Potassium; Rats; Stereoisomerism | 1990 |
The effects of stimulators of intracellular cyclic AMP on rat and chick osteoclasts in vitro: validation of a simplified light microscope assay of bone resorption.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Resorption; Bucladesine; Cell Movement; Chick Embryo; Colforsin; Cyclic AMP; In Vitro Techniques; Microscopy; Observer Variation; Osteoclasts; Rats; Reproducibility of Results; Tolonium Chloride; Video Recording | 1990 |
cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Biological Transport; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Humans; In Vitro Techniques; Isoproterenol; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Time Factors | 1991 |
Phosphorylation of microtubule-associated protein-2 in GH3 cells. Regulation by cAMP and by calcium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Homeostasis; Kinetics; Microtubule-Associated Proteins; Peptide Mapping; Phosphates; Phosphopeptides; Phosphorylation; Pituitary Neoplasms; Protein Kinases; Rats; Signal Transduction; Vasoactive Intestinal Peptide | 1991 |
Cholera toxin induces expression of the immediate-early response gene JE via a cyclic AMP-independent signaling pathway.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Chemokine CCL2; Chemotactic Factors; Cholera Toxin; Colforsin; Cyclic AMP; Cyclooxygenase Inhibitors; Gene Expression Regulation; GTP-Binding Proteins; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Mice; Phosphoproteins; Phosphorylation; Protein Kinase C; Signal Transduction | 1991 |
Cyclic AMP agonists induce the phosphorylation of phospholipase C-tau and of a 76 kDa protein co-precipitated by anti-(phospholipase C-tau) monoclonal antibodies in BALB/c-3T3 cells. Relationship to inositol phosphate formation.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids; Animals; Antibodies, Monoclonal; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Inositol Phosphates; Kinetics; Mice; Mice, Inbred BALB C; Molecular Weight; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Type C Phospholipases | 1990 |
Two mechanisms of inhibition by prostaglandin E2 of hormone-dependent cell cAMP in the rat collecting tubule.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Animals; Arginine Vasopressin; Colforsin; Cyclic AMP; Dinoprostone; Indomethacin; Isoproterenol; Kidney Tubules, Collecting; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Signal Transduction; Xanthines | 1990 |
Effects of peptides of the secretin-glucagon family and cyclic nucleotides on tyrosine hydroxylase activity in sympathetic nerve endings.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; Heart Ventricles; Male; Nerve Endings; Nitroprusside; Protein Kinase C; Rats; Rats, Inbred Strains; Second Messenger Systems; Secretin; Sympathetic Nervous System; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1991 |
Cyclic AMP does not inhibit A23187-induced prostaglandin biosynthesis in cultured rabbit renal microvascular endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Endothelium, Vascular; Epoprostenol; Isoproterenol; Kidney Glomerulus; Microcirculation; Rabbits | 1990 |
Possible involvement of pertussis toxin-sensitive GTP-binding protein(s) in c-fos expression during differentiation of 3T3-L1 fibroblasts to adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Blotting, Northern; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Deoxyglucose; Dexamethasone; DNA-Binding Proteins; Fibroblasts; Glycerolphosphate Dehydrogenase; GTP-Binding Proteins; Insulin; Isoproterenol; Mice; Pertussis Toxin; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogenes; RNA; Virulence Factors, Bordetella | 1991 |
Modulation of calcium-activated non-specific cation currents by cyclic AMP-dependent phosphorylation in neurones of Helix.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Calcium; Colforsin; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Helix, Snails; Ion Channels; Neurons; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Serotonin | 1990 |
Multiple synergistic signal transduction pathways regulate c-fos expression in Swiss 3T3 cells: the role of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bombesin; Calcimycin; Colforsin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Mice; Phorbol 12,13-Dibutyrate; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Signal Transduction; Transcription, Genetic | 1990 |
The effects of cAMP on differentiation of cultured Schwann cells: progression from an early phenotype (04+) to a myelin phenotype (P0+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cell Adhesion Molecules, Neuronal; Cell Differentiation; Cell Division; Cholera Toxin; Colforsin; Cyclic AMP; Glial Fibrillary Acidic Protein; Membrane Glycoproteins; Myelin P0 Protein; Myelin Proteins; Nerve Growth Factors; Phenotype; Rats; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Schwann Cells; Sciatic Nerve | 1991 |
Forskolin down-regulates type-1 plasminogen activator inhibitor and tissue-type plasminogen activator and their mRNAs in human fibrosarcoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Colforsin; Cyclic AMP; Dexamethasone; Fibrosarcoma; Gene Expression Regulation; Humans; Kinetics; Nucleic Acid Hybridization; Plasminogen Inactivators; RNA, Messenger; Tissue Plasminogen Activator; Tumor Cells, Cultured | 1990 |
Stimulation of cAMP and phosphomonoester production by melanotropin in melanoma cells: 31P NMR studies.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Cell Line; Colforsin; Cyclic AMP; Kinetics; Magnetic Resonance Spectroscopy; Melanocyte-Stimulating Hormones; Melanoma, Experimental; Mice; Organophosphorus Compounds | 1991 |
Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Angina, Unstable; Angioplasty, Balloon, Coronary; Arachidonic Acid; Arachidonic Acids; Colforsin; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Humans; Oxygenases; Platelet Activation; Pre-Eclampsia; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1991 |
Activation of group II phospholipase A2 gene via two distinct mechanisms in rat vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Annexins; Aorta, Thoracic; Bucladesine; Calcium-Binding Proteins; Cells, Cultured; Colforsin; Cyclic AMP; Cytokines; Enzyme Induction; Glucocorticoids; Inflammation; Isoenzymes; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Signal Transduction | 1991 |
Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood; Cattle; Cell Division; Cell Line; Colforsin; Cyclic AMP; DNA; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Genes, myc; Kinetics; Prostaglandin D2; Thymidine | 1990 |
Priming effect of glucagon-like peptide-1 (7-36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Sincalide | 1991 |
Stimulation of chicken growth hormone release by phorbol esters.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Drug Interactions; Enzyme Activation; Growth Hormone; Growth Hormone-Releasing Hormone; Pancreas; Phorbol 12,13-Dibutyrate; Phorbol Esters; Pituitary Gland, Anterior; Protein Kinase C; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1990 |
Modulation of keratin intermediate filament distribution in vivo by induced changes in cyclic AMP-dependent phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acrylamide; Acrylamides; Adenylyl Cyclases; Animals; Cell Line; Colforsin; Cyclic AMP; Fluorescent Antibody Technique; Intermediate Filaments; Keratins; Pertussis Toxin; Phosphorylation; Virulence Factors, Bordetella | 1990 |
Serum-induced sensitization of cyclic AMP accumulation in 1321N1 human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Astrocytoma; Blood; Cholera Toxin; Colforsin; Culture Media; Cyclic AMP; Humans; In Vitro Techniques; Isoproterenol; Pertussis Toxin; Protein Kinase C; Receptors, Cell Surface; Staurosporine; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Cyclic AMP-independent activation of transcription factor NF-kappa B in HL60 cells by tumor necrosis factors alpha and beta.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Gene Expression Regulation; Humans; Kinetics; Leukemia; NF-kappa B; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1991 |
Cholera toxin- and forskolin-induced cyclic AMP accumulations of pig skin (epidermis). Modulation by chemicals which reveal the beta-adrenergic augmentation effect.
Topics: 1-Methyl-3-isobutylxanthine; Acitretin; Adenylyl Cyclases; Animals; Cholera Toxin; Colchicine; Colforsin; Cyclic AMP; Epidermis; Glucocorticoids; Hydrocortisone; Retinoids; Skin; Swine; Tretinoin | 1990 |
Current recording from sensory cilia of olfactory receptor cells in situ. I. The neuronal response to cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Caffeine; Cilia; Colforsin; Cyclic AMP; Cyclic GMP; Electrophysiology; In Vitro Techniques; Nasal Mucosa; Phosphodiesterase Inhibitors; Rana esculenta; Rana ridibunda; Sensory Receptor Cells; Smell | 1991 |
Inhibition of thrombin-induced tissue-type plasminogen activator release by agents which increase intracellular cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Colforsin; Cyclic AMP; Ear, External; In Vitro Techniques; Milrinone; Perfusion; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Solutions; Swine; Thrombin; Tissue Plasminogen Activator | 1990 |
Inhibition of the chick pineal rhythm in rate of thymidine incorporation by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chickens; Colforsin; Cyclic AMP; Cyclic GMP; Periodicity; Phosphodiesterase Inhibitors; Pineal Gland; Thymidine | 1991 |
Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Arteries; Bucladesine; Colforsin; Cyclic AMP; Dinoprostone; Enzyme Activation; In Vitro Techniques; Isometric Contraction; Isoproterenol; Male; Mesenteric Arteries; Milrinone; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Pertussis Toxin; Pyridones; Rats; Rats, Inbred WKY; Receptors, Adrenergic, beta; Renal Circulation; Sodium Fluoride; Sympathectomy; Vascular Resistance; Vasodilator Agents; Virulence Factors, Bordetella | 1990 |
Relaxation response of isolated canine veins to agents that act on the adenylate cyclase-cyclic AMP system: further investigation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Colforsin; Cyclic AMP; Dogs; Female; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Papaverine; Veins | 1990 |
Impaired cyclic AMP generation in outer medullary tubules of gentamicin-treated rats.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Arginine Vasopressin; Colforsin; Cyclic AMP; Depression, Chemical; Gentamicins; Kidney Medulla; Kidney Tubules, Distal; Loop of Henle; Male; Rats; Rats, Inbred Strains | 1990 |
Picomolar-affinity binding and inhibition of adenylate cyclase activity by melatonin in Syrian hamster hypothalamus.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Binding Sites; Colforsin; Cricetinae; Hypothalamus; Iodine Radioisotopes; Male; Melatonin; Mesocricetus; Radioligand Assay; Receptors, Melatonin; Receptors, Neurotransmitter | 1990 |
Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Division; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; In Vitro Techniques; Indomethacin; Inositol Phosphates; Insulin; Intercellular Signaling Peptides and Proteins; Mice; Mitogens; Peptides; Pertussis Toxin; Phosphatidylinositols; Phosphoproteins; Protein Kinase C; Signal Transduction; Type C Phospholipases; Virulence Factors, Bordetella; Wasp Venoms | 1991 |
Increased expression of thrombomodulin on the cultured human umbilical vein endothelial cells and mouse hemangioma cells by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Hemangioma; Humans; Interleukin-1; Mice; Receptors, Cell Surface; Receptors, Thrombin; RNA, Messenger; Tumor Necrosis Factor-alpha; Umbilical Veins | 1991 |
Inhibitory effects of ionophore A23187 on the release of thyroid hormone and colloid reabsorption in mouse thyroid glands.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcimycin; Calcium; Colforsin; Colloids; Cyclic AMP; Epithelium; Mice; Mice, Inbred BALB C; Microscopy, Electron; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1991 |
Evaluating atrial natriuretic peptide-induced cGMP production by particulate guanylyl cyclase stimulation in vitro and in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Cortex; Animals; Atrial Natriuretic Factor; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Guanylate Cyclase; Humans; Kidney Glomerulus; Kinetics; Muscle, Smooth, Vascular; Nitroprusside; Radioimmunoassay; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface | 1991 |
Norepinephrine and iloprost improve barrier function of human endothelial cell monolayers: role of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Aorta; Cells, Cultured; Colforsin; Cyclic AMP; Electric Conductivity; Endothelium, Vascular; Fluorescent Antibody Technique; Horseradish Peroxidase; Humans; Iloprost; Isoproterenol; Kinetics; Norepinephrine; Phentolamine; Propranolol; Umbilical Arteries; Venae Cavae | 1991 |
The effect of L-glutamate and related agents on adenylate cyclase in the cestode Hymenolepis diminuta.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cholera Toxin; Colforsin; Glutamates; Glutamic Acid; Guanylate Cyclase; Hymenolepiasis; Hymenolepis; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Serotonin; Virulence Factors, Bordetella | 1991 |
A voltage, calcium, and ATP sensitive non selective cation channel in human colonic tumor cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Adenosine Triphosphate; Calcimycin; Calcium; Cell Line; Cell Membrane; Clone Cells; Colforsin; Colonic Neoplasms; Cytosol; Humans; Ion Channels; Membrane Potentials | 1991 |
Glucose induces insulin gene transcription in a murine pancreatic beta-cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; Gallopamil; Genes; Glucose; Insulin; Insulinoma; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Promoter Regions, Genetic; Rats; Transcription, Genetic; Uridine Triphosphate | 1991 |
The possibility of participation of different protein kinases in the regulation of degradation of Glp6[125I]Tyr8SP6-11 with different endopeptidases in subcellular fractions of rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Brain; Cell Nucleus; Cerebral Cortex; Colforsin; Cyclic AMP; Cyclic GMP; Endopeptidases; Hippocampus; Neurotransmitter Agents; Peptide Fragments; Protease Inhibitors; Protein Kinases; Pyrrolidonecarboxylic Acid; Rats; Second Messenger Systems; Subcellular Fractions; Substance P; Synaptosomes; Tetradecanoylphorbol Acetate | 1991 |
Mammalian cell lines engineered to identify inhibitors of specific signal transduction pathways.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Base Sequence; Cell Line; Clone Cells; Colforsin; Female; Humans; Isoenzymes; Mice; Molecular Sequence Data; Placenta; Platelet-Derived Growth Factor; Pregnancy; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1991 |
Proliferative and synthetic activity of cells from reoccluded distal anastomosis and pharmacological therapy of this postoperative complication.
Topics: 1-Methyl-3-isobutylxanthine; Anastomosis, Surgical; Aorta; Arteriosclerosis; Cell Division; Colforsin; Collagen; Femoral Artery; Glycosaminoglycans; Graft Occlusion, Vascular; Humans; Verapamil | 1991 |
GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Biological Transport; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; In Vitro Techniques; Inositol Phosphates; Kinetics; Parietal Cells, Gastric; Peptide Fragments; Peptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1991 |
Relaxant effects of alpha-human atrial natriuretic peptide on venous smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Carbachol; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Peptide Fragments; Purinones; Saphenous Vein; Splenic Artery; Vasodilation | 1991 |
Leukotriene B4 increases intracellular calcium concentration and phosphoinositide metabolism in mouse osteoblasts via cyclic adenosine 3',5'-monophosphate-independent pathways.
Topics: 1-Methyl-3-isobutylxanthine; 1-Phosphatidylinositol 4-Kinase; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Calcium; Colforsin; Cyclic AMP; Dinoprostone; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Leukotriene B4; Mice; Osteoblasts; Parathyroid Hormone; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphotransferases | 1991 |
Determination of levels of cyclic AMP in the myenteric plexus of guinea-pig small intestine.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Electrophysiology; Enzyme Activation; Ganglia; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Myenteric Plexus; Nerve Tissue Proteins | 1991 |
Vasoactive intestinal polypeptide inhibits c-myc expression and growth of human gastric carcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Blotting, Northern; Cell Division; Colforsin; Cyclic AMP; Drug Synergism; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Proto-Oncogene Mas; RNA, Messenger; Stomach Neoplasms; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1991 |
Intracellular signaling of transcription and secretion of type IV collagen after angiotensin II-induced cellular hypertrophy in cultured proximal tubular cells.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Bucladesine; Cell Division; Cells, Cultured; Chromatography, Thin Layer; Colforsin; Collagen; Cyclic AMP; Epithelium; Kidney Tubules, Proximal; Mice; Phorbol Esters; Radioimmunoassay; Signal Transduction; Transcription, Genetic; Transfection; Virulence Factors, Bordetella | 1991 |
Volume regulation in rat pheochromocytoma cultured cells submitted to hypoosmotic conditions.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Gland Neoplasms; Amiloride; Animals; Colforsin; Hypotonic Solutions; Kinetics; Pheochromocytoma; Potassium Chloride; Quinine; Rats; Rubidium Radioisotopes; Sodium Chloride; Trifluoperazine; Tumor Cells, Cultured | 1991 |
Modulation of cis-diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3-isobutyl-1-methylxanthine in sensitive and resistant human ovarian carcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport; Cell Line; Cell Survival; Cisplatin; Colforsin; Cyclic AMP; Drug Resistance; Female; Humans; Kinetics; Ovarian Neoplasms; Protein Kinases | 1991 |
Expression of genes related to the extracellular matrix in human endothelial cells. Differential modulation by elevated glucose concentrations, phorbol esters, and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Basement Membrane; Blotting, Northern; Cells, Cultured; Colforsin; Collagen; Cyclic AMP; Endothelium, Vascular; Extracellular Matrix; Fibronectins; Gene Expression Regulation; Glucose; Humans; Microbial Collagenase; Protein Kinase C; Protein Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Transcription, Genetic | 1991 |
Activation of AP-1 by IL-1 and phorbol esters in T cells. Role of protein kinase A and protein phosphatases.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Ethers, Cyclic; Gene Expression Regulation; Interleukin-1; Mice; Okadaic Acid; Phosphoprotein Phosphatases; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1991 |
Decreased beta-adrenoceptor-mediated vasodilation in aorta from aged rats: possible involvement of a stimulatory GTP-binding protein.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aging; Animals; Aorta; Clenbuterol; Colforsin; Cyclic AMP; Female; GTP-Binding Proteins; Isoproterenol; Male; Muscle Relaxation; Phosphodiesterase Inhibitors; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Vasodilation | 1991 |
Effects of phosphodiesterase inhibitors on vasoactive intestinal peptide-induced relaxation of isolated guinea-pig trachea.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dinoprostone; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Papaverine; Phosphodiesterase Inhibitors; SRS-A; Trachea; Vasoactive Intestinal Peptide | 1991 |
Intracellular Na+ modulates the cAMP-dependent regulation of ion channels in the heart.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Channels; Cells, Cultured; Chloride Channels; Colforsin; Cyclic AMP; Guinea Pigs; Heart; Heart Ventricles; Homeostasis; Ion Channels; Isoproterenol; Kinetics; Membrane Potentials; Membrane Proteins; Sodium | 1991 |
Effects of forskolin and phosphodiesterase inhibitors on spinal antinociception by morphine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Colforsin; Cyclic AMP; Injections, Spinal; Male; Morphine; Nociceptors; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord | 1991 |
Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR).
Topics: 1-Methyl-3-isobutylxanthine; Antidepressive Agents; Biological Transport, Active; Bucladesine; Carrier Proteins; Cholera Toxin; Choriocarcinoma; Colforsin; Cyclic AMP; Female; Gramicidin; Humans; Kinetics; Nigericin; Ouabain; Placenta; Reserpine; Serotonin; Sodium; Tumor Cells, Cultured | 1991 |
Role of cyclic adenosine 3',5'-monophosphate in mediating the effect of prostaglandin E2 on decidualization in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Cell Nucleus; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Decidua; Dinoprostone; Dose-Response Relationship, Drug; Endometrium; Female; Indomethacin; Intermediate Filaments; Pregnancy; Rats; Rats, Inbred Strains | 1991 |
Effects of osmotic pressure and somatostatin on the cAMP messenger system of the osmosensitive prolactin cell of a teleost fish, the tilapia (Oreochromis mossambicus).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Kinetics; Male; Osmotic Pressure; Perciformes; Pituitary Gland, Anterior; Prolactin; Second Messenger Systems; Somatostatin | 1991 |
Modification of biological responses to interleukin-1 by agents that perturb signal transduction pathways.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Division; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Diglycerides; Dinoprostone; Flow Cytometry; Interleukin-1; Interleukin-2; Lymphocyte Activation; Mice; Pertussis Toxin; Protein Kinase C; Recombinant Proteins; Signal Transduction; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Regulation of Na-K-2Cl cotransport in osteoblasts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Line; Chlorides; Colforsin; Cyclic AMP; Dinoprostone; Egtazic Acid; Kinetics; Osteoblasts; Osteosarcoma; Ouabain; Parathyroid Hormone; Potassium; Rubidium; Second Messenger Systems; Sodium; Sodium-Potassium-Chloride Symporters; Tetradecanoylphorbol Acetate | 1991 |
Isolation and characterization of rat submandibular intralobular ducts.
Topics: 1-Methyl-3-isobutylxanthine; Amylases; Animals; Calcium; Cell Separation; Centrifugation, Density Gradient; Colforsin; Cyclic AMP; Epinephrine; Isoproterenol; Kallikreins; Male; Povidone; Rats; Rats, Inbred Strains; Silicon Dioxide; Submandibular Gland | 1991 |
Hypertrophy of isolated adult feline heart cells following beta-adrenergic-induced beating.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cardiomegaly; Cats; Cells, Cultured; Colforsin; Culture Techniques; Cyclic AMP; Heart; Heart Rate; Isoproterenol; Myocardial Contraction; Myocardium; Myofibrils; Nifedipine; Norepinephrine; Propranolol; Receptors, Adrenergic, beta | 1991 |
Effects of PGE2 and a thromboxane A2 analogue on uptake of IgG complexes and LDL by mesangial cells.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Actins; Animals; Biological Transport; Cells, Cultured; Colforsin; Dinoprostone; Dose-Response Relationship, Drug; Glomerular Mesangium; Humans; Immunoglobulin G; Kinetics; Lipoproteins, LDL; Prostaglandin Endoperoxides, Synthetic; Rats; Thromboxane A2 | 1991 |
Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Binding Sites; Colforsin; Cytochalasin B; Dipyridamole; Erythrocytes; Humans; Liver; Monosaccharide Transport Proteins; Myocardium; Rats | 1991 |
A novel LLC-PK1 renal epithelial cell mutant impaired in in vivo down-regulation of cAMP-mediated hormonal response.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Arginine Vasopressin; Calcitonin; Cell Line; Colforsin; Cyclic AMP; Drug Resistance; Enzyme Activation; Epithelium; Guanylyl Imidodiphosphate; Kidney; Mutation; Protein Kinases; Swine | 1991 |
Hepatocanalicular organic-anion transport is regulated by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Anion Transport Proteins; Anions; Bile Canaliculi; Biological Transport; Bucladesine; Carrier Proteins; Colforsin; Cyclic AMP; Glucagon; Glutathione; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1991 |
Dark-induced supersensitivity of dopamine D-1 and D-2 receptors in rat retina.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Darkness; Dopamine; Light; Male; Proteins; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Retina; Sulpiride | 1991 |
Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 5'-Nucleotidase; Adenosine; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Morphine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rolipram; Spinal Cord; Synaptosomes | 1991 |
Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Juxtaglomerular Apparatus; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Renin | 1991 |
Differential regulation of surface Ig- and Lyb2-mediated B cell activation by cyclic AMP. I. Evidence for alternative regulation of signaling through two different receptors linked to phosphatidylinositol hydrolysis in murine B cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Ly; B-Lymphocytes; Calcium; Cholera Toxin; Colforsin; Cyclic AMP; Female; Hydrolysis; Lymphocyte Activation; Mice; Mice, Inbred Strains; Phosphatidylinositols; Protein Kinases; Receptors, Antigen; Receptors, Antigen, B-Cell; Receptors, Transferrin; Signal Transduction | 1991 |
Cyclic AMP accumulation induces a rapid desensitization of the cyclic AMP-dependent protein kinase in mouse striatal neurons.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Carrier Proteins; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Edetic Acid; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Kinetics; Macromolecular Substances; Mice; Neurons; Protein Kinases; Vasoactive Intestinal Peptide; Zinc | 1991 |
8-hydroxy-2-(di-N-propylamino)tetralin increases the activity of adenylate cyclase in the hippocampus of freely-moving rats.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Behavior, Animal; Colforsin; Cyclic AMP; Dialysis; Hippocampus; Male; Norepinephrine; Radioimmunoassay; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes | 1991 |
Regulation by forskolin of cyclic AMP phosphodiesterase and protein kinase C activity in LLC-PK1 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Cells, Cultured; Colforsin; Cyclic GMP; Galactose; Macaca mulatta; Pregnenolone; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Animals; Atenolol; Clenbuterol; Colforsin; Cyclic AMP; Glucagon; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1991 |
Inhibition of cAMP production by alpha 2-adrenoceptor stimulation in rabbit retina.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Colforsin; Cyclic AMP; GTP-Binding Proteins; In Vitro Techniques; Pertussis Toxin; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Retina; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1991 |
cAMP negatively regulates mRNA levels of actin and tropomyosin in rat cultured vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Animals; Base Sequence; Bucladesine; Cells, Cultured; Colforsin; Consensus Sequence; Cyclic AMP; Dactinomycin; Immunoblotting; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligonucleotides; Phenotype; Rats; Rats, Inbred Strains; RNA, Messenger; Tropomyosin | 1991 |
Protein kinase C down-regulation enhances cAMP-mediated induction of urokinase-type plasminogen activator mRNA in LLC-PK1 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Northern; Bucladesine; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Gene Expression; Protein Kinase C; Protein Kinases; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Urokinase-Type Plasminogen Activator | 1991 |
Cyclic AMP modulates differentially the release of dopamine induced by hypoxia and other stimuli and increases dopamine synthesis in the rabbit carotid body.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Carotid Body; Colforsin; Cyclic AMP; Dopamine; Hypoxia; Norepinephrine; Oxygen; Partial Pressure; Rabbits; Stimulation, Chemical | 1991 |
Milrinone inhibits sympathetic-mediated tachycardia by a postjunctional action independent of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiotonic Agents; Colforsin; Cyclic AMP; Decerebrate State; Electric Stimulation; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Milrinone; Nitroprusside; Norepinephrine; Pyridones; Rats; Rats, Inbred Strains; Sympathetic Nervous System | 1991 |
cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Colforsin; Cyclic AMP; Enhancer Elements, Genetic; Enkephalins; Gene Expression Regulation; Genes, fos; Glioma; Humans; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Protein Biosynthesis; Protein Kinases; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reticulocytes; Second Messenger Systems; Transcriptional Activation; Transfection | 1991 |
Regulation of endogenous chloride conductance in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bumetanide; Calcium; Chloride Channels; Colforsin; Cyclic AMP; Cytosol; Female; Iodides; Iodine Radioisotopes; Ion Channels; Isoproterenol; Kinetics; Membrane Potentials; Membrane Proteins; Oocytes; ortho-Aminobenzoates; Rubidium; Rubidium Radioisotopes; Thionucleotides; Xenopus laevis | 1991 |
Regulation of peptide-YY synthesis and secretion in fetal rat intestinal cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Cells, Cultured; Chromatography, High Pressure Liquid; Colforsin; Drug Synergism; Gastric Inhibitory Polypeptide; Gastrin-Releasing Peptide; Immunoenzyme Techniques; Intestinal Mucosa; Intestines; Peptide Biosynthesis; Peptide YY; Peptides; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 1991 |
Effects of cyclic AMP and phorbol ester on transepithelial electrical resistance of Sertoli cell monolayers in two-compartment culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Electric Conductivity; Epithelium; Follicle Stimulating Hormone; Intercellular Junctions; Male; Rats; Rats, Inbred Strains; Second Messenger Systems; Sertoli Cells; Tetradecanoylphorbol Acetate | 1991 |
Enhanced lipolysis in 3T3-L1 adipocytes following prolonged exposure to tolbutamide.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Bucladesine; Cell Differentiation; Colforsin; Cycloheximide; Glycerol; Isoproterenol; Kinetics; Lipolysis; Mice; Tolbutamide | 1991 |
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dinoprostone; Epoprostenol; Hyperalgesia; Male; Phosphorylation; Protein Kinases; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Second Messenger Systems; Sensory Thresholds; Thionucleotides | 1991 |
Cyclic AMP modulates sensory-neural communication at the vestibular end organ.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Afferent Pathways; Animals; Bucladesine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Epithelium; Evoked Potentials; Hair Cells, Auditory; In Vitro Techniques; Membrane Potentials; Physical Stimulation; Rana pipiens; Vestibule, Labyrinth | 1991 |
Follitropin receptor down-regulation involves a cAMP-dependent post-transcriptional decrease of receptor mRNA expression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Down-Regulation; Follicle Stimulating Hormone; Gene Expression Regulation; Male; Rats; Rats, Inbred Strains; Receptors, FSH; RNA, Messenger; Sertoli Cells; Transcription, Genetic | 1991 |
Effects of histamine and activators of the cyclic AMP system on protein synthesis in and release of high molecular weight glycoproteins from isolated gastric non-parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Separation; Chromatography, Gel; Colforsin; Cyclic AMP; Gastric Mucosa; Glycoproteins; Histamine; In Vitro Techniques; Molecular Weight; Protein Biosynthesis; Ranitidine; Swine | 1991 |
Control of HCO3-dependent exchangers by cyclic nucleotides in vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Bicarbonates; Biological Transport, Active; Colforsin; Cyclic AMP; Cyclic GMP; Fluorescent Dyes; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Exchange; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1991 |
Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atropine; Calcium Channel Blockers; Carbachol; Cell Differentiation; Cell Line; Colforsin; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryo, Nonmammalian; Heart; Heart Rate; Isoproterenol; Membrane Potentials; Myocardium; Parasympathomimetics; Phenylephrine; Prazosin; Stem Cells; Sympathomimetics | 1991 |
Effect of L-asparaginase on insulin secretion from isolated rat islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Asparaginase; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Male; Rats; Rats, Inbred Strains; Tolbutamide | 1991 |
Triiodothyronine (T3) inhibition of growth hormone secretion by chicken pituitary cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Analysis of Variance; Animals; Calcimycin; Cells, Cultured; Chickens; Colforsin; Diglycerides; Dose-Response Relationship, Drug; Growth Hormone; Growth Hormone-Releasing Hormone; In Vitro Techniques; Male; Pituitary Gland, Anterior; Radioimmunoassay; Second Messenger Systems; Tetradecanoylphorbol Acetate; Triiodothyronine | 1991 |
Histamine-induced increases in cyclic AMP levels in bovine adrenal medullary cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Medulla; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin System; Colforsin; Cyclic AMP; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Radioimmunoassay; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3 | 1991 |
Differential and coordinate regulation of TH and PNMT mRNAs in chromaffin cell cultures by second messenger system activation and steroid treatment.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Medulla; Animals; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Enzyme Induction; Phenylethanolamine N-Methyltransferase; RNA, Messenger; Second Messenger Systems; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tyrosine 3-Monooxygenase | 1991 |
Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Bone and Bones; Bucladesine; Carrier Proteins; Cell Division; Colforsin; Cyclic AMP; Dinoprostone; Humans; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor II; Molecular Sequence Data; Osteosarcoma; Tumor Cells, Cultured | 1991 |
Reconstruction of the thyroid follicle with long-term cultured cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Collagen; Cyclic AMP; Insulin; Microscopy, Electron; Swine; Thyroid Gland; Thyrotropin | 1991 |
Further characterization of the iodide inhibitory effect on the cyclic AMP system in dog thyroid slices.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine Triphosphate; Alprostadil; Animals; Calcium; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Dogs; Iodides; Iodine Radioisotopes; Methimazole; Prostaglandins E; Protein Biosynthesis; RNA; Thyroid Gland; Thyrotropin; Triiodothyronine | 1985 |
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Relation to cAMP concentration and Ca2+ uptake.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Diterpenes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Nifedipine; Oxazoles; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide; Verapamil | 1985 |
Octopamine enhances dark-adaptation in Limulus ventral photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dark Adaptation; Diterpenes; Horseshoe Crabs; Octopamine | 1985 |
Histamine content and release of isolated rat gastric mucosal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Colforsin; Diterpenes; Gastric Mucosa; Histamine; Histamine Release; In Vitro Techniques; Rats | 1985 |
Direct effect of parathyroid hormone on the proliferation of osteoblast-like cells; a possible involvement of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcimycin; Cell Count; Cell Division; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Dinoprostone; Diterpenes; DNA; Dose-Response Relationship, Drug; Osteoblasts; Parathyroid Hormone; Prostaglandins E; Thymidine; Time Factors | 1985 |
Kinetic and quantitative relationships between insulin release and 65Zn efflux from perifused islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Diterpenes; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Leucine; Male; Rats; Zinc; Zinc Radioisotopes | 1985 |
Stimulation of cyclic adenosine 3',5'-monophosphate production enhances hypothalamic luteinizing hormone-releasing hormone release without increasing prostaglandin E2 synthesis: studies in prepubertal female rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Cholera Toxin; Colforsin; Cyclic AMP; Dinoprostone; Diterpenes; Female; Gonadotropin-Releasing Hormone; Hypothalamus; Median Eminence; Pertussis Toxin; Prostaglandins E; Rats; Rats, Inbred Strains; Sexual Maturation; Virulence Factors, Bordetella | 1985 |
Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Blood Platelets; Calcium; Colforsin; Cyclic AMP; Cytosol; Diterpenes; Fluorescent Dyes; Humans; Platelet Activating Factor; Platelet Aggregation; Thrombin | 1985 |
Activation of cyclic GMP-binding and cyclic AMP-specific phosphodiesterases of rat platelets by a mechanism involving cyclic AMP-dependent phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Platelets; Colforsin; Cyclic AMP; Diterpenes; Enzyme Activation; Male; Phosphorylation; Protein Kinases; Rats | 1985 |
Relation between cyclic adenosine monophosphate and prostaglandin output by dispersed cells from human amnion and decidua.
Topics: 1-Methyl-3-isobutylxanthine; Albuterol; Amnion; Bucladesine; Calcimycin; Cholera Toxin; Colforsin; Cyclic AMP; Decidua; Diterpenes; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; In Vitro Techniques; Isoproterenol; Prostaglandins E; Prostaglandins F; Stimulation, Chemical; Trifluoperazine | 1985 |
Forskolin stimulation of 3, 5, 3'-triiodothyronine release from perifused rat thyroids.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Male; Perfusion; Rats; Rats, Inbred Strains; Thyroid Gland; Triiodothyronine | 1985 |
Role of adenosine 3',5'-cyclic monophosphate in adrenoceptor-mediated control of 3H-noradrenaline secretion in guinea-pig ileum myenteric nerve terminals.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Ileum; In Vitro Techniques; Isoproterenol; Male; Myenteric Plexus; Nerve Endings; Nicotinic Acids; Norepinephrine; Phosphodiesterase Inhibitors; Propranolol; Receptors, Adrenergic; Yohimbine | 1985 |
Increased cyclic AMP in cultured vascular smooth muscle cells and relaxation of aortic strips by parathyroid hormone.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta, Thoracic; Cattle; Colforsin; Cyclic AMP; Drug Synergism; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Papaverine; Parathyroid Hormone; Rabbits; Sodium Fluoride; Time Factors | 1985 |
Muscarinic cholinergic inhibition of beta-adrenergic stimulation of phospholamban phosphorylation and Ca2+ transport in guinea pig ventricles.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Biological Transport; Calcium; Calcium-Binding Proteins; Colforsin; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Female; Guinea Pigs; Heart Ventricles; Isoproterenol; Kinetics; Male; Myocardial Contraction; Myocardium; Phosphorus Radioisotopes; Phosphorylation; Receptors, Adrenergic, beta; Receptors, Muscarinic | 1985 |
cAMP- and beta-adrenergic-stimulated chloride-dependent Ca2+ secretion in frog skin.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Biological Transport; Calcium; Chlorides; Colforsin; Cyclic AMP; Electric Conductivity; Female; Furosemide; Isoproterenol; Parathyroid Hormone; Rana pipiens; Skin; Stimulation, Chemical; Sympathomimetics; Thionucleotides; Vasopressins | 1985 |
Cyclic AMP mediates the negative regulation of Y-organ ecdysteroid production.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brachyura; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Ecdysone; Female; Invertebrate Hormones; Kinetics; Neurosecretory Systems | 1985 |
Forskolin stimulates bovine epididymal sperm motility and cyclic AMP levels.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bicarbonates; Cattle; Cell Membrane; Colforsin; Cyclic AMP; Dibucaine; Epididymis; Kinetics; Male; Manganese; Sodium Fluoride; Sperm Motility; Spermatozoa; Theophylline | 1985 |
Cyclic AMP stimulates serotonin N-acetyltransferase activity in Xenopus retina in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Acetyltransferases; Adenosine; Animals; Arylamine N-Acetyltransferase; Bucladesine; Calcium; Circadian Rhythm; Colforsin; Cyclic AMP; Darkness; Fishes; Guinea Pigs; In Vitro Techniques; Light; Melatonin; Retina; Tyrosine 3-Monooxygenase; Xenopus laevis | 1986 |
Effects of calcium on the vasopressin-sensitive cAMP metabolism in medullary tubules.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Animals; Arginine Vasopressin; Calcimycin; Calcium; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Ibuprofen; Kidney Tubules; Kidney Tubules, Collecting; Male; Naproxen; Rats; Rats, Inbred Strains; Rotenone; Vasopressins | 1985 |
Evidence for an inhibitory role of cyclic AMP in the control of juvenile hormone biosynthesis by cockroach corpora allata.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Monophosphate; Age Factors; Animals; Attention; Cockroaches; Colforsin; Corpora Allata; Cyclic AMP; Female; In Vitro Techniques; Juvenile Hormones; Nucleotides, Cyclic; Radioimmunoassay; Time Factors; Vitellogenesis | 1985 |
Steroidogenesis in ovarian cells of the Japanese quail (Coturnix coturnix japonica).
Topics: 1-Methyl-3-isobutylxanthine; Androstenedione; Animals; Chickens; Colforsin; Coturnix; Estrogens; Female; Granulosa Cells; Hydroxycholesterols; Kinetics; Luteinizing Hormone; Ovarian Follicle; Progesterone; Quail; Steroids; Theca Cells | 1985 |
Augmentation of isoproterenol-stimulated tissue cyclic AMP level by cholinergic agonists in rat parotid gland.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Atropine; Calcimycin; Calcium; Carbachol; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Isoproterenol; Male; Methacholine Chloride; Methacholine Compounds; Norepinephrine; Oxotremorine; Parotid Gland; Phentolamine; Pilocarpine; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains | 1985 |
Thyrotropin upregulates alpha 1-adrenergic receptors in rat FRTL-5 thyroid cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Norepinephrine; Prazosin; Rats; Receptors, Adrenergic, alpha; Thyroid Gland; Thyrotropin | 1985 |
Identified octopaminergic neurons modulate contractions of locust visceral muscle via adenosine 3',5'-monophosphate (cyclic AMP).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biogenic Amines; Colforsin; Cyclic AMP; Female; Grasshoppers; In Vitro Techniques; Muscle Contraction; Muscles; Octopamine; Oviducts; Synaptic Transmission | 1986 |
Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4-phosphate in intact human platelets.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Blood Platelets; Colforsin; Cyclic AMP; Humans; In Vitro Techniques; Phosphatidylinositol Phosphates; Phosphatidylinositols | 1986 |
Cyclic AMP-calcium interaction in the transmission of tubuloglomerular feedback signals.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Calcium; Colforsin; Cyclic AMP; Feedback; Kidney Glomerulus; Kidney Tubules; Kidney Tubules, Distal; Male; Perfusion; Pressure; Rats; Rats, Inbred Strains | 1985 |
Parathyroid hormone inhibition of Na+-H+ antiporter activity in a cultured renal cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Amiloride; Animals; Carrier Proteins; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; Hexoses; Kidney; Monensin; Opossums; Ouabain; Oxygen Consumption; Parathyroid Hormone; Sodium-Hydrogen Exchangers | 1986 |
D-2 dopaminergic agonists and adenosine 3',5'-monophosphate directly regulate the synthesis of alpha-melanocyte-stimulating hormone-like peptides by cultured rat melanotrophs.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzamides; Benzazepines; Bromocriptine; Cells, Cultured; Chemical Precipitation; Cholera Toxin; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Dopamine; Ergolines; Immunologic Techniques; Melanocyte-Stimulating Hormones; Pituitary Gland; Pro-Opiomelanocortin; Quinpirole; Rats; Receptors, Dopamine; Spiperone | 1986 |
Effect of phosphodiesterase inhibitors on Sertoli cell refractoriness: reversal of the impaired androgen aromatization.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Estrogens; Follicle Stimulating Hormone; Isoproterenol; Male; Phosphodiesterase Inhibitors; Rats; Receptors, Cell Surface; Receptors, FSH; Sertoli Cells | 1986 |
Stimulation of adenosine 3',5'-monophosphate production in rat Sertoli cells by alpha-melanotropin-stimulating hormone (alpha MSH) and des-acetyl alpha MSH.
Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; alpha-MSH; Animals; beta-Endorphin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Endorphins; Follicle Stimulating Hormone; Male; Melanocyte-Stimulating Hormones; Peptide Fragments; Rats; Rats, Inbred Strains; Sertoli Cells | 1986 |
Sodium-dependent phosphate transport inhibited by parathyroid hormone and cyclic AMP stimulation in an opossum kidney cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport, Active; Bucladesine; Cattle; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dinoprostone; Dose-Response Relationship, Drug; Kidney; Monosaccharide Transport Proteins; Opossums; Parathyroid Hormone; Phosphates; Prostaglandins E; Sodium; Time Factors | 1986 |
Control of growth in cultured rat thyroid cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Division; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Rats; Rats, Inbred F344; Thyroid Gland; Thyrotropin | 1986 |
Effects of several newer cardiotonic drugs on cardiac cyclic AMP metabolism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclases; Aminopyridines; Amrinone; Animals; Cardiotonic Agents; Colforsin; Cyclic AMP; Enoximone; Guinea Pigs; Hydrolysis; Imidazoles; Isoenzymes; Milrinone; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pyridones | 1986 |
Effect of cyclic AMP on collagen production by corneal fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cattle; Cells, Cultured; Cholera Toxin; Colforsin; Collagen; Cornea; Cyclic AMP; Fibroblasts; Isoproterenol; Receptors, Adrenergic, beta | 1986 |
The role of cyclic adenosine 3',5'-monophosphate in the ovulatory process of the in vitro perfused rabbit ovary.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Estradiol; Female; In Vitro Techniques; Kinetics; Luteinizing Hormone; Ovary; Ovulation; Progesterone; Rabbits; Testosterone | 1986 |
1,25-Dihydroxyvitamin D3 and adenosine 3',5'-monophosphate synergistically promote differentiation of a monocytic cell line.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Calcitriol; Cell Differentiation; Cell Line; Colforsin; Complement C5; Complement C5a; Cyclic AMP; Dinoprostone; Drug Synergism; Humans; Isoproterenol; Lymphoma; Monocytes; Prostaglandins E; Receptor, Anaphylatoxin C5a; Receptors, Complement | 1986 |
Role of adenylate cyclase in presynaptic alpha 2-adrenoceptor- and mu-opioid receptor-mediated inhibition of [3H]noradrenaline release from rat brain cortex slices.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Cadmium; Calcimycin; Cerebral Cortex; Clonidine; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Norepinephrine; Phentolamine; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Rolipram | 1986 |
Ca2+-, phorbol ester-, and cAMP-stimulated enzyme secretion from permeabilized rat pancreatic acini.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Calcium; Carbachol; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cytoplasmic Granules; Digitonin; Egtazic Acid; Pancreas; Phorbols; Rats; Rats, Inbred Strains; Saponins; Spermine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1986 |
Osmolality, vasopressin-stimulated cAMP, and PGE2 synthesis in rat collecting tubule cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Calcimycin; Colforsin; Cyclic AMP; Dinoprostone; Kidney Tubules; Kidney Tubules, Collecting; Osmolar Concentration; Phosphodiesterase Inhibitors; Prostaglandins E; Rats; Rats, Inbred Strains; Sodium Chloride; Stimulation, Chemical; Urea | 1986 |
Evaluation of the effects of forskolin and the antilipolytic agents insulin and nicotinic acid on cyclic AMP levels in rat epididymal adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Deaminase; Adipose Tissue; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Insulin; Kinetics; Niacin; Rats | 1986 |
Effects of cyclic adenosine 3':5'-monophosphate upon glycoprotein and carcinoembryonic antigen synthesis and release by human colon cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Carcinoembryonic Antigen; Cell Line; Cholera Toxin; Colforsin; Colonic Neoplasms; Cyclic AMP; Glycoproteins; Humans; Neoplasm Proteins | 1986 |
Characteristics of the desensitization of growth hormone and cyclic AMP responses to growth hormone-releasing factor and prostaglandin E2 in rat anterior pituitary cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dinoprostone; Drug Tolerance; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Kinetics; Nifedipine; Pituitary Gland, Anterior; Prostaglandins E; Rats; Rats, Inbred Strains | 1986 |
Effect of forskolin and phosphodiesterase inhibition on prostacyclin-stimulated steroid production in goat ovarian cell types.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Corpus Luteum; Dose-Response Relationship, Drug; Epoprostenol; Estradiol; Female; Goats; Granulosa Cells; Ovary; Phosphodiesterase Inhibitors; Progesterone; Theca Cells | 1986 |
Adenosine 3',5'-cyclic monophosphate stimulates dopamine biosynthesis in the median eminence of rat hypothalamic slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cycloheximide; Dihydroxyphenylalanine; Dopamine; Drug Synergism; Female; Median Eminence; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin | 1986 |
Endothelium-independent linkage of parathyroid hormone receptors of rat vascular tissue with increased adenosine 3',5'-monophosphate and relaxation of vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta, Thoracic; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium; Isoproterenol; Male; Membrane Proteins; Muscle Relaxation; Muscle, Smooth, Vascular; Papaverine; Parathyroid Hormone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Parathyroid Hormone; Teriparatide | 1986 |
Cyclic adenosine 3',5'-monophosphate mediates beta-receptor actions of noradrenaline in rat hippocampal pyramidal cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Adenine; Adenylyl Cyclase Inhibitors; Animals; Calcium; Colforsin; Cyclic AMP; Guanylyl Imidodiphosphate; Hippocampus; In Vitro Techniques; Isoproterenol; Neurons; Norepinephrine; Potassium; Rats | 1986 |
Somatostatin inhibits corticotropin-releasing factor-stimulated adrenocorticotropin release, adenylate cyclase, and activation of adenosine 3',5'-monophosphate-dependent protein kinase isoenzymes in AtT20 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Cell Line; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoenzymes; Mice; Pituitary Neoplasms; Protein Kinases; Somatostatin; Thionucleotides | 1986 |
Evidence that adenosine 3',5'-monophosphate mediates stimulation of thyroid growth in FRTL5 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Division; Cell Line; Colforsin; Cyclic AMP; DNA; Epidermal Growth Factor; Immunoglobulin G; Immunoglobulins, Thyroid-Stimulating; Rats; Thyroid Gland; Thyrotropin | 1986 |
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Animals; Colforsin; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glucagon; Insulinoma; Isoproterenol; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate | 1986 |
Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adrenergic alpha-Agonists; Aluminum; Aluminum Compounds; Angiotensin II; Calcium; Colforsin; Cyclic AMP; Drug Synergism; Fluorides; Glucagon; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Liver; Pertussis Toxin; Phorbols; Protein Kinase C; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thionucleotides; Vasopressins; Virulence Factors, Bordetella | 1986 |
Prostaglandin E2 stimulates DNA synthesis by a cyclic AMP-independent pathway in osteoblastic clone MC3T3-E1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Clone Cells; Colforsin; Cyclic AMP; Deoxyadenosines; Dideoxyadenosine; Dinoprostone; DNA; Mice; Osteoblasts; Prostaglandins E | 1986 |
Parathyroid hormone stimulation of alkaline phosphatase activity in cultured neonatal mouse calvarial bone cells: involvement of cyclic AMP and calcium.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Alkaline Phosphatase; Animals; Bone and Bones; Calcimycin; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Mice; Parathyroid Hormone; Peptide Fragments; Prostaglandins E; Skull | 1986 |
The stimulatory effect of forskolin on gastric acid secretion in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cimetidine; Colforsin; Dose-Response Relationship, Drug; Gastric Acid; Histamine; Male; Rats; Rats, Inbred Strains; Stimulation, Chemical; Time Factors | 1986 |
Regulation of insulin secretion by cAMP in rat islets of Langerhans permeabilised by high-voltage discharge.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cell Membrane Permeability; Colforsin; Cyclic AMP; Electric Stimulation; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Stimulation, Chemical | 1986 |
The releasing action of calcium upon cyclic AMP-dependent meiotic arrest in hamster oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcimycin; Calcium; Calcium Chloride; Cells, Cultured; Colforsin; Cricetinae; Cyclic AMP; Egtazic Acid; Female; Meiosis; Mesocricetus; Oocytes | 1986 |
Cyclic adenosine monophosphate, calcium, acetylcholine and the current induced by adenosine in the Xenopus oocyte.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenosine; Animals; Calcimycin; Calcium; Colforsin; Cyclic AMP; Egtazic Acid; Electrophysiology; Female; Isoproterenol; Oocytes; Potassium; Progesterone; Xenopus laevis | 1986 |
On the mechanism of muscarinic inhibition of the cardiac Ca current.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Action Potentials; Animals; Calcium; Colforsin; Cyclic AMP; Female; Guanylyl Imidodiphosphate; Guinea Pigs; Heart; Ion Channels; Isoproterenol; Male; Perfusion; Pertussis Toxin; Protein Kinases; Virulence Factors, Bordetella | 1986 |
Prostanoid inhibition of canine parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Aminopyrine; Animals; Carbachol; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Dogs; Enprostil; Histamine; Parietal Cells, Gastric; Prostaglandins E; Prostaglandins E, Synthetic; Stimulation, Chemical | 1986 |
Carbachol inhibits electrophysiological effects of cyclic AMP in ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cell Separation; Colforsin; Cyclic AMP; Electrophysiology; Guinea Pigs; Heart; Heart Ventricles; Isoproterenol; Myocardium; Time Factors | 1986 |
Pharmacological characteristics of receptor-operated and potential-operated Ca2+ channels in rat aorta.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Calcium; Colforsin; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Nifedipine; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Receptors, Cell Surface | 1986 |
Role of cAMP in modulating intrafollicular progesterone levels and oocyte maturation in amphibians (Rana pipiens).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; Female; Oocytes; Oogenesis; Ovary; Pituitary Hormones; Progesterone; Rana pipiens | 1986 |
Stimulation of sulfated-proteoglycan synthesis by forskolin in monolayer cultures of rabbit articular chondrocytes.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cartilage, Articular; Cells, Cultured; Chemical Phenomena; Chemistry; Chondroitin Sulfate Proteoglycans; Colforsin; Cyclic AMP; Glycosaminoglycans; Proteoglycans; Rabbits; Stimulation, Chemical | 1986 |
Effects of forskolin on contractility and cyclic AMP levels in rabbit detrusor muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Muscle Contraction; Muscles; Propranolol; Rabbits | 1986 |
Prostacyclin production by isolated rat adipocytes: evidence for cyclic adenosine 3',5'-monophosphate-dependent and independent mechanisms and for a selective effect of insulin.
Topics: 1-Methyl-3-isobutylxanthine; 6-Ketoprostaglandin F1 alpha; Adipose Tissue; Adrenergic beta-Antagonists; Angiotensin II; Animals; Colforsin; Cyclic AMP; Dexamethasone; Epoprostenol; Insulin; Isoproterenol; Male; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Effect of a high fat diet on rat adipocyte lipolysis: responses to epinephrine, forskolin, methylisobutylxanthine, dibutyryl cyclic AMP, insulin and nicotinic acid.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Body Weight; Bucladesine; Colforsin; Dietary Fats; Epinephrine; Insulin; Lipolysis; Niacin; Rats; Rats, Inbred Strains | 1986 |
Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Aging; Bucladesine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Iodocyanopindolol; Isoproterenol; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Pindolol; Receptors, Adrenergic, beta; Serotonin | 1986 |
Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Autoradiography; Baclofen; Bicuculline; Cerebellum; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Pertussis Toxin; Rats; Receptors, GABA-A; Time Factors; Virulence Factors, Bordetella | 1986 |
Induction of tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: effect of the inducing agents alone or in combination on the enzyme levels and rate of synthesis of tyrosine hydroxylase.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animals; Cell Line; Cholera Toxin; Colforsin; Culture Media; Cyclic AMP; Dexamethasone; Drug Interactions; Enzyme Induction; Glucocorticoids; Pheochromocytoma; Rats; Tyrosine 3-Monooxygenase | 1986 |
Impaired cAMP metabolism associated with abnormal function of thrombopathic canine platelets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Platelet Disorders; Blood Platelets; Colforsin; Cyclic AMP; Dogs; Platelet Aggregation; Platelet Function Tests; Serotonin | 1986 |
Effect of forskolin on cAMP accumulation and ketogenesis in isolated hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Glucagon; Hypothyroidism; In Vitro Techniques; Ketone Bodies; Liver; Male; Rats | 1986 |
Role of calcium in luteinizing hormone-induced progesterone and cyclic AMP production in granulosa cells of the hen (Gallus domesticus).
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Chickens; Colforsin; Cyclic AMP; Female; Gallic Acid; Granulosa Cells; In Vitro Techniques; Luteinizing Hormone; Progesterone | 1986 |
Enhanced activation of cAMP-dependent protein kinase by rapid synthesis and degradation of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cattle; Cell Line; Cell Membrane; Colforsin; Cyclic AMP; Enzyme Activation; Kinetics; Protein Kinases | 1986 |
Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Calcimycin; Cell Adhesion; Colforsin; Cyclic AMP; Enzyme Activation; Humans; Myelin Basic Protein; Neuroglia; Oligodendroglia; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone and Bones; Bone Resorption; Calcium; Colforsin; Cyclic AMP; Dinoprostone; In Vitro Techniques; Indomethacin; Kinetics; Lysosomes; Mice; Parathyroid Hormone; Prostaglandins E; Pyrrolidinones; Rolipram; Theophylline | 1986 |
Effects of forskolin on electrical behaviour of myenteric neurones in guinea-pig small intestine.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Colforsin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Intestine, Small; Magnesium; Muscle, Smooth; Myenteric Plexus; Neurons; Potassium; Synapses; Tetrodotoxin; Time Factors | 1986 |
Copper amplification of prostaglandin E2 stimulation of the release of luteinizing hormone-releasing hormone is a postreceptor event.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Copper; Dinoprostone; Drug Synergism; Gonadotropin-Releasing Hormone; Histidine; Male; Median Eminence; Organ Culture Techniques; Prostaglandins E; Rats; Receptors, LHRH | 1987 |
Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Calcium; Cardiotonic Agents; Colforsin; Cyclic AMP; Heart Failure; Humans; Isoproterenol; Milrinone; Myocardial Contraction; Myocardium; Pyridones; Stimulation, Chemical; Strophanthidin | 1987 |
Elevation of cAMP in cultured mesangial cells diminishes vasopressin-stimulated increases of phosphate uptake and 32P-specific activity in ATP but has no effect on phosphoinositide metabolism.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Glomerular Mesangium; Isoproterenol; Phosphates; Phosphatidylinositols; Vasopressins | 1987 |
Potentiation of PGE1-induced increase in cyclic AMP by chemotactic peptide and Ca2+ ionophore through calmodulin-dependent processes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alprostadil; Animals; Calcimycin; Calmodulin; Colforsin; Cyclic AMP; Drug Synergism; Female; Guanosine Triphosphate; Guinea Pigs; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Prostaglandin Antagonists; Sulfonamides; Tetradecanoylphorbol Acetate | 1987 |
Tryptamine and some related molecules block the accumulation of a light-sensitive pool of cyclic AMP in the dark-adapted, dark-incubated mouse retina.
Topics: 1-Methyl-3-isobutylxanthine; 5-Methoxytryptamine; Animals; Cobalt; Colforsin; Cyclic AMP; Dark Adaptation; Light; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Photoreceptor Cells; Retina; Serotonin; Serotonin Antagonists; Tryptamines | 1987 |
Paradoxical stimulation of human sperm motility by 2-deoxyadenosine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Caffeine; Calcimycin; Colforsin; Cyclic AMP; Deoxyadenosines; Freezing; Humans; Male; Sperm Motility; Spermatozoa; Stimulation, Chemical | 1986 |
The release of choline from phospholipids mediated by beta-adrenoceptor activation in isolated hearts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Chickens; Choline; Colforsin; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Myocardium; Phospholipids; Quinacrine; Receptors, Adrenergic, beta; Receptors, Muscarinic | 1986 |
Alpha 1-adrenergic regulation of TSH-stimulated cyclic AMP accumulation in rat thyroid cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Animals; Catecholamines; Cell Line; Colforsin; Cyclic AMP; GTP-Binding Proteins; Pertussis Toxin; Phenylisopropyladenosine; Rats; Receptors, Adrenergic, alpha; Thyroid Gland; Thyrotropin; Virulence Factors, Bordetella | 1987 |
Catecholamine stimulation of androgen production by rat Leydig cells. Interactions with luteinizing hormone and luteinizing hormone-releasing hormone.
Topics: 1-Methyl-3-isobutylxanthine; Androgens; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Gonadotropin-Releasing Hormone; Isoproterenol; Kinetics; Leydig Cells; Luteinizing Hormone; Male; Rats; Rats, Inbred Strains | 1986 |
Increase in cAMP levels in beta-cell line potentiates insulin secretion without altering cytosolic free-calcium concentration.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Line; Colforsin; Cricetinae; Cyclic AMP; Insulin; Insulin Secretion; Islets of Langerhans | 1987 |
Repetitive axonal discharges elicited by serotonin and intracellular adenosine 3',5'-cyclic monophosphate in the crayfish neuromuscular junction.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Astacoidea; Axons; Colforsin; Cyclic AMP; Evoked Potentials; In Vitro Techniques; Neuromuscular Junction; Serotonin; Theophylline | 1986 |
Characterization of two mutants of the LLC-PK1 porcine kidney cell line affected in the catalytic subunit of the cAMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Chromatography, Ion Exchange; Colforsin; Cyclic AMP; Isoenzymes; Kidney; Kinetics; Macromolecular Substances; Mutation; Phenotype; Protein Kinases; Swine | 1987 |
Intralysosomal hydrolysis of thyroglobulin: specific and cAMP-mediated activation by TSH.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzimidazoles; Bucladesine; Colforsin; Cyclic AMP; Hydrolysis; Kinetics; Lysosomes; Nocodazole; Puromycin; Swine; Thyroglobulin; Thyroid Gland; Thyrotropin | 1987 |
Regulation of Y-organ ecdysteroidogenesis by molt-inhibiting hormone in crabs: involvement of cyclic AMP-mediated protein synthesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brachyura; Bucladesine; Calcimycin; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Ecdysone; Ecdysterone; Endocrine Glands; Female; Invertebrate Hormones; Kinetics; Organ Culture Techniques; Protein Biosynthesis; RNA | 1986 |
Adenylate cyclase stimulation alters transport in frog retinal pigment epithelium.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alloxan; Animals; Biological Transport; Chlorides; Chlorpromazine; Colforsin; Cyclic AMP; Dopamine; Enzyme Activation; In Vitro Techniques; Membrane Potentials; Pigment Epithelium of Eye; Potassium; Rana catesbeiana; Sodium; Water-Electrolyte Balance | 1987 |
The effect of cyclic AMP on the accumulation of newly synthesized protein in the extracellular matrix of PFHR-9 teratocarcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Cell Division; Cell Line; Colforsin; Collagen; Cyclic AMP; DNA; Extracellular Matrix; Proline; Protein Biosynthesis; Teratoma | 1987 |
Cyclic AMP inhibits the synthesis and release of prolactin from human decidual cells.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Decidua; Female; Humans; Methionine; Pregnancy; Prolactin | 1987 |
Calcium dependence of vasoactive intestinal peptide-stimulated cyclic AMP accumulation in rat hippocampal slices.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Calcium; Calmodulin; Colforsin; Cyclic AMP; Female; Hippocampus; Magnesium; Norepinephrine; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains; Vasoactive Intestinal Peptide | 1987 |
Parathyroid hormone-induced changes in cyclic nucleotide levels during relaxation of the rabbit [correction of rat] aorta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parathyroid Hormone; Rabbits | 1987 |
Glucose stimulates insulin release without altering cyclic AMP production or inositolphospholipid turnover in freshly obtained human insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Carbachol; Colforsin; Cyclic AMP; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Phosphatidylinositols | 1987 |
Cyclic adenosine-3',5'-monophosphate stimulates the acute release of placental lactogen from human trophoblast cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Female; Humans; Kinetics; Placental Lactogen; Pregnancy; Theophylline; Trophoblasts | 1987 |
Activation and desensitization of glycolysis by stimulation of adenylate cyclase in rat reticulocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Glucosephosphates; Glycolysis; Isoproterenol; Male; Rats; Rats, Inbred Strains; Reticulocytes; Sodium-Potassium-Exchanging ATPase; Stimulation, Chemical | 1987 |
alpha-MSH-induced changes in protein phosphorylation of Cloudman S91 mouse melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Melanocyte-Stimulating Hormones; Melanoma, Experimental; Mice; Molecular Weight; Phosphoproteins; Phosphorylation | 1987 |
Epidermal growth factor activates steroid biosynthesis in cultured Leydig tumor cells without affecting the levels of cAMP and potentiates the activation of steroid biosynthesis by choriogonadotropin and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Aminoglutethimide; Animals; Bucladesine; Cholera Toxin; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Epidermal Growth Factor; Leydig Cell Tumor; Mice; Phosphodiesterase Inhibitors; Progesterone; Steroids | 1987 |
Effect of dietary lipids on inotropic responses of isolated rat left atrium: attenuation of maximal responses by an unsaturated fat diet.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Bucladesine; Colforsin; Dietary Fats; Epinephrine; Fatty Acids, Unsaturated; Female; Heart Atria; Isoproterenol; Myocardial Contraction; Norepinephrine; Phenylephrine; Pregnancy; Rats; Rats, Inbred Strains | 1987 |
Participation of Ca2+ and calmodulin in rat pancreatic enzyme secretion induced by secretin, forskolin, and dibutyryl cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Amylases; Animals; Bucladesine; Calcium; Calmodulin; Colforsin; Pancreas; Pancreatic Juice; Rats; Secretin; Secretory Rate; Sulfonamides | 1986 |
Regulation of insulin release independent of changes of cytosolic Ca2+ concentration.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Cyclic AMP; Cytosol; Digitonin; Epinephrine; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Norepinephrine; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Forskolin-insensitive adenylate cyclase in cultured cells of Choristoneura fumiferana (Insecta).
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cell Line; Colforsin; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Lepidoptera; Octopamine; Sodium Fluoride | 1987 |
Inhibition of FSH augmented adenylate cyclase activity in porcine granulosa cells by ovarian protein.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Female; Follicle Stimulating Hormone; Granulosa Cells; Guanylyl Imidodiphosphate; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Kinetics; Peptides; Swine; Trichloroacetic Acid | 1987 |
Enhanced cAMP accumulation after termination of cholinergic action in the heart.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Atropine; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Heart; Isoproterenol; Methacholine Chloride; Methacholine Compounds; Myocardial Contraction; Myocardium; Parasympathomimetics; Pindolol; Receptors, Muscarinic | 1987 |
Glucocorticoid enhancement of adrenocorticotropin-induced 3',5'-cyclic adenosine monophosphate production by cultured ovine adrenocortical cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Cortex; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cells, Cultured; Colforsin; Corticosterone; Cosyntropin; Cyclic AMP; Dexamethasone; Estrenes; Glucocorticoids; Hydrocortisone; Mifepristone; Sheep | 1987 |
Is calcium or cyclic AMP involved in the inhibitory effect on pituitary hormone secretion of the tripeptide aldehyde proteinase inhibitors?
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Female; Growth Hormone; Kinetics; Oligopeptides; Pituitary Gland, Anterior; Potassium; Prolactin; Rats; Rats, Inbred Strains | 1987 |
Potentiation of cholinergic responses in mouse parotid gland by a cAMP dependent mechanism involves cGMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Mice; Parasympathetic Nervous System; Parotid Gland | 1987 |
Interaction of phosphodiesterase inhibitors triamterene, papaverine, theophylline, IBMX and amrinone with other positive inotropic acting substances on isolated guinea-pig atria.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Colforsin; Drug Interactions; Electric Stimulation; Guinea Pigs; Heart Rate; Histamine; In Vitro Techniques; Male; Metaproterenol; Myocardial Contraction; Papaverine; Phosphodiesterase Inhibitors; Stimulation, Chemical; Theophylline; Triamterene | 1987 |
P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Creatine Kinase; Cyclic AMP; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Liver; Male; Phosphocreatine; Purine Nucleotides; Rats; Rats, Inbred Strains; Receptors, Purinergic; Sugar Phosphates | 1987 |
Nerve growth factor treatment or cAMP elevation reduces Ca2+/calmodulin-dependent protein kinase III activity in PC12 cells.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adrenal Gland Neoplasms; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cytosol; Elongation Factor 2 Kinase; Epidermal Growth Factor; Kinetics; Nerve Growth Factors; Pheochromocytoma; Phosphorylation; Protein Kinases | 1987 |
Forskolin and thyrotrophin stimulation of rat FRTL-5 thyroid cell growth: the role of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Colforsin; Cyclic AMP; Metaphase; Mitosis; Stimulation, Chemical; Thyroid Gland; Thyrotropin | 1987 |
Mechanism for amine modulation of the neurogenic Limulus heart: evidence for involvement of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biogenic Amines; Colforsin; Cyclic AMP; Cyclic GMP; Dopamine; Heart; Horseshoe Crabs; Myocardium; Octopamine | 1987 |
Synergism between cellular messengers and agonist combinations in pepsinogen secretion.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bethanechol; Bethanechol Compounds; Bombesin; Calcimycin; Calcium; Cell Communication; Colforsin; Cyclic AMP; Drug Synergism; Esophagus; Fluorescent Antibody Technique; Isoproterenol; L-Lactate Dehydrogenase; Pepsinogens; Protein Kinase C; Rana catesbeiana; Tetradecanoylphorbol Acetate | 1987 |
Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Alprostadil; Blood Platelets; Colforsin; Cyclic AMP; Diglycerides; Enzyme Activation; Epinephrine; Humans; Prostaglandin D2; Prostaglandins D; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
Cyclic AMP-regulating agents inhibit endotoxin-mediated cartilage degradation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cartilage; Cattle; Colforsin; Culture Techniques; Cyclic AMP; Dose-Response Relationship, Drug; Endotoxins; Proteoglycans; Theophylline | 1987 |
Two types of hormone-responsive adenylate cyclase in the rat liver.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Glucagon; Glucose; In Vitro Techniques; Insulin; Kinetics; Liver; Liver Glycogen; Male; Oxymetazoline; Perfusion; Rats; Rats, Inbred Strains; Secretin | 1987 |
Effect of forskolin, isoproterenol and IBMX on angiotensin converting enzyme and cyclic AMP production by cultured bovine endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Isoproterenol; Kinetics; Peptidyl-Dipeptidase A; Theophylline | 1987 |
Development and function of B cells in monolayer islet cells of 3-week-old rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Deoxyglucose; Fluorodeoxyglucose F18; Insulin; Insulin Secretion; Iodoacetates; Iodoacetic Acid; Islets of Langerhans; Microscopy, Phase-Contrast; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Time Factors | 1987 |
Regulation of adipokinetic hormone release from locust neuroendocrine tissue: participation of calcium and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Cyclic AMP; Grasshoppers; In Vitro Techniques; Insect Hormones; Neurosecretory Systems; Octopamine; Oligopeptides; Pyrrolidonecarboxylic Acid | 1987 |
Cyclic nucleotides and atherosclerosis: studies in primary culture of human aortic cells.
Topics: 1-Methyl-3-isobutylxanthine; Aorta; Arteriosclerosis; Cell Division; Cholesterol; Colforsin; Culture Techniques; DNA; Humans; Nucleotides, Cyclic; Phospholipids; Proteins; Risk Factors; Triglycerides | 1987 |
Mediation of norepinephrine-stimulated cyclic AMP accumulation by adrenergic receptors in hypothalamic and preoptic area slices: effects of estradiol.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Agonists; Animals; Colforsin; Cyclic AMP; Estradiol; Female; Hypothalamus; Norepinephrine; Preoptic Area; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sympatholytics; Tamoxifen | 1987 |
Stimulation of acetylcholine release from myenteric neurons of guinea pig small intestine by forskolin and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Bucladesine; Colforsin; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Intestine, Small; Muscle Contraction; Myenteric Plexus; Theophylline | 1987 |
Somatostatin and muscarinic inhibition of canine enteric endocrine cells: cellular mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Epinephrine; Gastrointestinal Hormones; Glucagon-Like Peptides; GTP-Binding Proteins; Ileum; Intestinal Mucosa; Neurotensin; Pertussis Toxin; Receptors, Muscarinic; Somatostatin; Virulence Factors, Bordetella | 1987 |
Effects of TMB-8, a calcium antagonist, on transport properties of the isolated canine tracheal epithelium.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Chlorides; Colforsin; Dinoprost; Dinoprostone; Dogs; Epithelium; Gallic Acid; Phenobarbital; Prostaglandins E; Prostaglandins F; Sodium; Trachea | 1987 |
Adenosine 3',5'-monophosphate mediates both the mitogenic effect of thyrotropin and its ability to amplify the response to insulin-like growth factor I in FRTL5 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; DNA; DNA Replication; Insulin-Like Growth Factor I; Kinetics; Rats; Somatomedins; Thyroid Gland; Thyrotropin | 1988 |
The action of prostaglandins on ureter smooth muscle of guinea-pig.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dinoprost; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth; Prostaglandins E; Prostaglandins F; Ureter; Uterine Contraction | 1987 |
Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Basophils; Colforsin; Cyclic AMP; Histamine Release; Humans; Isoproterenol; Kinetics; Lung; Male; Mast Cells; Mice; Rats; Rats, Inbred Strains | 1988 |
Activators of protein kinase C act at a postreceptor site to amplify cyclic AMP production in rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic alpha-Agonists; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Enzyme Activation; Female; Phenylephrine; Phorbol Esters; Pineal Gland; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate | 1988 |
Ketoconazole inhibits corticotropic cell function in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Ketoconazole; Male; Pituitary Gland, Anterior; Pro-Opiomelanocortin; Rats; Rats, Inbred Strains; RNA, Messenger | 1988 |
Metabolic antagonism between insulin action and activators of adenylate cyclase in rat fat cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adipose Tissue; Animals; Colforsin; Enzyme Activation; Epinephrine; Fatty Acids; Female; Glycerol; Insulin; Isoproterenol; Lipids; Rats; Rats, Inbred Strains | 1987 |
Locus of inhibitory action of cAMP-dependent protein kinase in the antigen receptor-triggered cytotoxic T lymphocyte activation pathway.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Cholera Toxin; Colforsin; Cyclic AMP; Cytotoxicity, Immunologic; Exocytosis; Lymphocyte Activation; Protein Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1988 |
Adenylate cyclase in human cytotrophoblasts: characterization and its role in modulating human chorionic gonadotropin secretion.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Chlorides; Cholera Toxin; Chorionic Gonadotropin; Colforsin; Female; Guanylyl Imidodiphosphate; Humans; Magnesium; Magnesium Chloride; Manganese; Manganese Compounds; Protein Kinases; Trophoblasts | 1988 |
Clonidine inhibits the isoproterenol-induced desensitization of the beta noradrenergic activated adenylate cyclase system in astrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Astrocytes; Clonidine; Colforsin; Cyclic AMP; Enzyme Activation; Isoproterenol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1987 |
Alpha 2-adrenergic receptors in brown adipose tissue of infant rats--II. Studies on function and regulation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adipose Tissue, Brown; Animals; Clonidine; Colforsin; Hydroxydopamines; Kinetics; Lipolysis; Oxidopamine; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathectomy, Chemical; Virulence Factors, Bordetella; Yohimbine | 1988 |
cAMP elevation modulates physiological activity of pyloric neurons in the lobster stomatogastric ganglion.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Digestive System; Ganglia; In Vitro Techniques; Models, Neurological; Nephropidae; Neurons; Theophylline | 1987 |
Neuromodulator-mediated phosphorylation of specific proteins in a neurotumor hybrid cell line (NCB-20).
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Alprostadil; Animals; Brain; Calcimycin; Colforsin; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Immunoassay; Mice; Nerve Tissue Proteins; Neuroblastoma; Neurotransmitter Agents; Phosphoproteins; Phosphorylation; Protein Kinases; Serotonin; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1988 |
Pharmacological modulation of CRH-stimulated ACTH secretion by ketoconazole.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adrenocorticotropic Hormone; Animals; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Ketoconazole; Male; Pituitary Gland, Anterior; Pro-Opiomelanocortin; Rats; Rats, Inbred Strains; RNA, Messenger; Sodium Fluoride | 1987 |
Evidence that growth hormone depletion and uncoupling of the regulatory protein of adenylate cyclase (Ns) both contribute to the desensitization of growth hormone responses to growth hormone-releasing factor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Growth Hormone; Growth Hormone-Releasing Hormone; GTP-Binding Proteins; Pituitary Gland, Anterior; Rats; Tetradecanoylphorbol Acetate | 1988 |
On the role of cyclic nucleotides in the pathogenesis of human atherosclerosis.
Topics: 1-Methyl-3-isobutylxanthine; Aorta; Arteriosclerosis; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic GMP; Humans; Lipid Metabolism; Organ Culture Techniques | 1987 |
Possible mechanism of regulating adenylate cyclase activity in adipocyte membranes from exercise-trained male rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipose Tissue; Animals; Cell Membrane; Cholera Toxin; Colforsin; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Male; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1988 |
Serotonin acting via cyclic AMP enhances both the hyperpolarizing and depolarizing phases of bursting pacemaker activity in the Aplysia neuron R15.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Aplysia; Calcium; Colforsin; Cyclic AMP; Dopamine; Drug Synergism; Electrophysiology; Neurons; Serotonin | 1988 |
Egg-laying hormone, serotonin, and cyclic nucleotide modulation of ionic currents in the identified motoneuron B16 of Aplysia.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aplysia; Colforsin; Cyclic GMP; Electrophysiology; Invertebrate Hormones; Membrane Potentials; Motor Neurons; Serotonin | 1988 |
Effects of cyclic nucleotides and calcium on transduction and encoding processes in frog muscle spindle.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Barium; Barium Compounds; Bucladesine; Calcium Chloride; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chlorides; Colforsin; In Vitro Techniques; Muscles; Quercetin; Rana catesbeiana | 1988 |
Characteristics of desensitization of insulin secretion in fully in vitro systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Male; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1988 |
Influence of androgenic status on the alpha 2/beta-adrenergic control of lipolysis in white fat cells: predominant alpha 2-antilipolytic response in testosterone-treated-castrated hamsters.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Brimonidine Tartrate; Clonidine; Colforsin; Cricetinae; Cyclic AMP; Epinephrine; Isoproterenol; Lipolysis; Male; Mesocricetus; Niacin; Orchiectomy; Phentolamine; Propranolol; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Testosterone | 1988 |
The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Blood; Colforsin; Cyclic AMP; Fibroblasts; Gene Expression Regulation; Growth Substances; Mice; Mice, Inbred BALB C; Mutation; Oligonucleotides; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transfection | 1988 |
Phorbol esters modulate cyclic AMP accumulation in porcine thyroid cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dinoprostone; Phorbol 12,13-Dibutyrate; Phorbol Esters; Prostaglandins E; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1988 |
Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenal Gland Neoplasms; Colforsin; Cyclic AMP; Electric Conductivity; Enzyme Activation; Ion Channels; Kinetics; Pheochromocytoma; Potassium; Theophylline; Tumor Cells, Cultured | 1988 |
Modulation of acetylcholine receptor desensitization by forskolin is independent of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenylyl Cyclases; Animals; Bucladesine; Colforsin; Cyclic AMP; Electric Conductivity; Enzyme Activation; Kinetics; Muscles; Phosphorylation; Rats; Receptors, Cholinergic; Torpedo | 1988 |
Evidence of cyclic AMP-independent action of glucagon on calcium mobilization in rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Aequorin; Angiotensin II; Animals; Calcium; Colforsin; Cyclic AMP; Glucagon; Liver; Rats; Vasopressins | 1988 |
Pharmacological elevation of cyclic AMP and transmitter release at the mouse neuromuscular junction.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cholera Toxin; Colforsin; Cyclic AMP; Evoked Potentials; Fluorides; In Vitro Techniques; Mice; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Theophylline | 1988 |
The effect of parathyroid hormone and atrial natriuretic peptide on cyclic nucleotides production and proliferation of avian epiphyseal growth plate chondroprogenitor cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenocorticotropic Hormone; Animals; Atrial Natriuretic Factor; Cartilage; Cells, Cultured; Chick Embryo; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic GMP; Dinoprostone; Growth Plate; Kinetics; Parathyroid Hormone; Peptide Fragments; Prostaglandins E | 1988 |
Inhibition of gonadotropin-responsive adenylate cyclase in MA-10 Leydig tumor cells by epidermal growth factor.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Isoproterenol; Leydig Cell Tumor; Luteal Cells; Mice; Rats; Tumor Cells, Cultured | 1988 |
Regulation of fibronectin biosynthesis by dexamethasone, transforming growth factor beta, and cAMP in human cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Cell Division; Cell Line; Colforsin; Cyclic AMP; Dexamethasone; Fibronectins; Gene Expression Regulation; Humans; Peptides; Promoter Regions, Genetic; RNA, Messenger; Transforming Growth Factors | 1988 |
Use of pharmacologic antagonists to deduce commonalities of biologic activity among clostridial neurotoxins.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Acetylcholine; Amifampridine; Aminopyridines; Ammonium Chloride; Animals; Botulinum Toxins; Calcium; Cholera Toxin; Colforsin; Female; Guanidine; Guanidines; In Vitro Techniques; Methylamines; Mice; Neuromuscular Junction; Neurotoxins; Tetanus Toxin; Theophylline | 1988 |
In vivo evidence that an adenylate cyclase-cAMP system dilates cerebral arterioles in mice.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Arteries; Arterioles; Colforsin; Cyclic AMP; Male; Mice; Mice, Inbred ICR; Pia Mater; Vasodilation | 1988 |
Insulin biosynthesis in HIT cells. Effects of glucose, forskolin, IBMX, and dexamethasone.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Transformation, Viral; Colforsin; Dexamethasone; Glucose; Insulin; Islets of Langerhans; Proinsulin; Stimulation, Chemical; Time Factors | 1988 |
Modulation of cyclic AMP and autoregulation of renal blood flow, analysed by the use of forskolin and 1-methyl-3-isobutylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dimethyl Sulfoxide; Dogs; Female; Male; Renal Circulation; Theophylline | 1988 |
Increased cholera toxin-, and forskolin-induced cyclic AMP accumulations in psoriatic involved versus uninvolved or normal human epidermis.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Cholera Toxin; Colforsin; Cyclic AMP; Epidermis; Humans; Male; Psoriasis; Receptors, Adrenergic, beta | 1988 |
Isoproterenol-induced desensitization of mucin release in isolated rat submandibular acini.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Dose-Response Relationship, Drug; Glucosamine; Isoproterenol; Male; Mucins; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Submandibular Gland | 1988 |
Evidence for reduced beta-adrenoceptor coupling to adenylate cyclase in femoral arteries from spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Colforsin; Femoral Artery; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Phenoxybenzamine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta | 1988 |
Adenylate cyclase activation is not sufficient to stimulate somatostatin release from dispersed cerebral cortical and diencephalic cells in glia-free cultures.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Colforsin; Cytarabine; Diencephalon; Immunohistochemistry; Neurons; Rats; Somatostatin; Time Factors; Vasoactive Intestinal Peptide | 1988 |
Reduced function of the stimulatory GTP-binding protein in beta adrenoceptor-adenylate cyclase system of femoral arteries isolated from spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Femoral Artery; GTP-Binding Proteins; Hypertension; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Species Specificity; Vasoconstriction | 1988 |
Muscarinic receptor-mediated increase in cAMP levels in SK-N-SH human neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Carbachol; Cell Line; Colforsin; Cyclic AMP; Humans; Kinetics; Neuroblastoma; Oxotremorine; Pertussis Toxin; Receptors, Muscarinic; Virulence Factors, Bordetella | 1988 |
Increased adenylate cyclase catalytic activity explains how estrogens "in vivo" promote lipolytic activity in rat white fat cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adipose Tissue; Animals; Colforsin; Epinephrine; Estradiol; Female; Isoproterenol; Kinetics; Lipolysis; Ovariectomy; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Modulation of a human lymphoblastoid B cell line by cyclic AMP. Ig secretion and phosphatidylcholine metabolism.
Topics: 1-Methyl-3-isobutylxanthine; Adjuvants, Immunologic; B-Lymphocytes; Bucladesine; Cell Line, Transformed; Cholera Toxin; Choline; Colforsin; Cyclic AMP; Humans; Immunoglobulins; Phosphatidylcholines; Phosphorus Radioisotopes; Tetradecanoylphorbol Acetate | 1988 |
Interaction of forskolin with the effect of atropine on [3H]acetylcholine secretion in guinea-pig ileum myenteric plexus.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Aminopyridines; Animals; Atropine; Colforsin; Cyclic GMP; Drug Interactions; Guinea Pigs; Ileum; In Vitro Techniques; Myenteric Plexus; Neuromuscular Junction | 1988 |
Relationships of secretagogue-induced cAMP accumulation and acid secretion in elutriated rat gastric parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyrine; Animals; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Fluorescence; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Isoproterenol; Male; Microscopy, Electron; Radioimmunoassay; Rats; Rats, Inbred Strains | 1988 |
On the mechanism of isoprenaline- and forskolin-induced depolarization of single guinea-pig ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Action Potentials; Albuterol; Animals; Colforsin; Cyclic AMP; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Isoproterenol; Male; Metoprolol; Myocardium; Sodium; Temperature | 1988 |
Cyclic AMP: a second messenger of the newly characterized AVP-like insect diuretic hormone, the migratory locust diuretic hormone.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids; Animals; Arginine Vasopressin; Colforsin; Cyclic AMP; Grasshoppers; Insect Hormones; Malpighian Tubules; Molecular Sequence Data; Radioimmunoassay | 1988 |
Forskolin has both stimulatory and inhibitory effects on bone resorption in fetal rat long bone cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone and Bones; Bone Development; Bone Resorption; Calcium; Colforsin; Cyclic AMP; Organ Culture Techniques; Parathyroid Hormone; Rats | 1986 |
Reduction of beta-adrenoceptor density and evaluation of positive inotropic responses in isolated, diseased human myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Bucladesine; Calcium; Cardiac Output, Low; Cardiotonic Agents; Colforsin; Digitoxin; Digoxin; Dobutamine; Histamine; Humans; In Vitro Techniques; Middle Aged; Myocardial Contraction; Myocardium; Receptors, Adrenergic, beta; Stimulation, Chemical | 1988 |
Adenosine 3',5'-cyclic monophosphate (cAMP) inhibits phorbol ester-induced growth of an IL-2-dependent T cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Cell Division; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; DNA Replication; Humans; Interleukin-2; Kinetics; Phorbol 12,13-Dibutyrate; Recombinant Proteins; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1988 |
Cyclic AMP potentiates phorbol ester stimulation of tissue plasminogen activator release and inhibits secretion of plasminogen activator inhibitor-1 from human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Glycoproteins; Humans; Phorbol Esters; Plasminogen Inactivators; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1988 |
Mechanism of Li inhibition of vasopressin-sensitive adenylate cyclase in cultured renal epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Biological Transport; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Epithelium; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kidney; Kinetics; Lithium; Magnesium; Sodium Fluoride; Swine; Vasopressins | 1988 |
Cyclic AMP-mediated stabilization of osteocalcin mRNA in rat osteoblast-like cells treated with parathyroid hormone.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Binding Proteins; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Isoproterenol; Kinetics; Osteoblasts; Osteocalcin; Osteosarcoma; Parathyroid Hormone; Peptide Fragments; Rats; RNA, Messenger; Teriparatide | 1988 |
Cyclic AMP increasing agents rapidly stimulate vimentin phosphorylation in quiescent cultures of Swiss 3T3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Isoelectric Point; Mice; Molecular Weight; Phosphorylation; Vimentin | 1988 |
Early effects of parathyroid hormone on membrane potential of rat osteoblasts in culture: role of cAMP and Ca2+.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcimycin; Calcium; Cells, Cultured; Cobalt; Colforsin; Cyclic AMP; Egtazic Acid; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Membrane Potentials; Microelectrodes; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Rats; Second Messenger Systems | 1988 |
Inhibition of atrial natriuretic peptide secretion by forskolin in noncontracting cultured atrial myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Atrial Natriuretic Factor; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic GMP; Egtazic Acid; Muscle Contraction; Muscle, Smooth, Vascular; Protein Kinase C; Ryanodine; Sarcoplasmic Reticulum; Secretory Rate; Tetradecanoylphorbol Acetate | 1988 |
Regulation of differentiation of the BC3H1 muscle cell line through cAMP-dependent and -independent pathways.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Bucladesine; Cell Differentiation; Cell Line; Colforsin; Creatine Kinase; Cyclic AMP; Fibroblast Growth Factors; Kinetics; Mice; Muscles; Ornithine Decarboxylase; Proto-Oncogenes; Receptors, Cholinergic; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Troponin; Troponin T | 1988 |
Regulation by dibutyryl cyclic AMP of carnosine synthesis in astroglia-rich primary cultures kept in serum-free medium.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Carnosine; Cells, Cultured; Colforsin; Culture Media; Dexamethasone; Dipeptides; Insulin; Mice; Neuroglia; Tetradecanoylphorbol Acetate; Transferrin | 1989 |
Differential induction of c-fos and c-myc by cyclic AMP in Swiss 3T3 cells: significance for the mitogenic response.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Animals; Bombesin; Cell Division; Colforsin; Cyclic AMP; DNA Replication; Fibroblasts; Gene Expression Regulation; Insulin; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Signal Transduction | 1988 |
The in vitro activation of cyclic AMP production by either forskolin or isoproterenol in the Syrian hamster pineal during the day is not accompanied by an increase in melatonin production.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Circadian Rhythm; Colforsin; Cricetinae; Cyclic AMP; Isoproterenol; Kinetics; Male; Melatonin; Mesocricetus; Organ Culture Techniques; Pineal Gland | 1988 |
Induction of ornithine decarboxylase activity in isolated chicken osteoblasts by parathyroid hormone: the role of cAMP and calcium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Calcium; Calmodulin; Chickens; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Fibroblasts; Magnesium; Ornithine Decarboxylase; Osteoblasts; Parathyroid Hormone | 1988 |
Regulation of growth hormone secretion and cyclic AMP metabolism in ovine pituitary cells: interactions involved in activation induced by growth hormone-releasing hormone and phorbol esters.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Growth Hormone; Growth Hormone-Releasing Hormone; Phorbol Esters; Pituitary Gland; Sheep; Tetradecanoylphorbol Acetate; Time Factors | 1988 |
Excitation of locus coeruleus neurons by an adenosine 3',5'-cyclic monophosphate-activated inward current: extracellular and intracellular studies in rat brain slices.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Neurons; Rats; Reference Values; Theophylline | 1987 |
Inhibition by forskolin of insulin-stimulated glucose transport in L6 muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Cells, Cultured; Colforsin; Cyclic AMP; Dideoxyadenosine; Dideoxynucleosides; Glucose; Hexoses; Insulin; Muscles; Phorbol 12,13-Dibutyrate | 1988 |
Sphingosine and psychosine, suggested inhibitors of protein kinase C, inhibit LH effects in rat luteal cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brain; Bucladesine; Colforsin; Corpus Luteum; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Female; Luteal Cells; Luteinizing Hormone; Progesterone; Protein Kinase C; Psychosine; Rats; Rats, Inbred Strains; Sphingosine | 1988 |
Cyclic AMP only partially mediates the actions of serotonin at lobster neuromuscular junctions.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Electrophysiology; Muscle Contraction; Nephropidae; Neuromuscular Junction; Serotonin; Time Factors | 1989 |
Role of stimulatory GTP-binding protein (Gs) in reduced beta-adrenoceptor coupling in the femoral artery of spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Antagonists; Animals; Bucladesine; Cholera Toxin; Colforsin; Femoral Artery; GTP-Binding Proteins; Guanosine Triphosphate; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Timolol | 1988 |
Expression and regulation of the proenkephalin gene in rat Sertoli cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Colforsin; Dihydrotestosterone; Enkephalins; Follicle Stimulating Hormone; Gene Expression Regulation; Male; Protein Precursors; Rats; RNA; Sertoli Cells; Testosterone; Time Factors | 1989 |
Bone Gla protein messenger ribonucleic acid is regulated by both 1,25-dihydroxyvitamin D3 and 3',5'-cyclic adenosine monophosphate in rat osteosarcoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcitriol; Calcium-Binding Proteins; Cell Count; Cholera Toxin; Colforsin; Cyclic AMP; Dactinomycin; Gene Expression Regulation; Osteocalcin; Osteosarcoma; Parathyroid Hormone; Pertussis Toxin; Rats; RNA, Messenger; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
Modulation of adenylate cyclase activity in cultured bovine pulmonary arterial endothelial cells. Effects of adenosine and derivatives.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Cattle; Cells, Cultured; Colforsin; Endothelium, Vascular; Guanylyl Imidodiphosphate; Pulmonary Artery; Receptors, Adrenergic, beta; Receptors, Purinergic; Structure-Activity Relationship | 1989 |
Attenuation of endotoxin-induced cytotoxicity and prostacyclin production in cultured bovine pulmonary artery endothelial cells by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; 6-Ketoprostaglandin F1 alpha; Adenylyl Cyclases; Animals; Bucladesine; Cattle; Cell Survival; Cells, Cultured; Colforsin; Cyclic GMP; Endothelium, Vascular; Ferricyanides; L-Lactate Dehydrogenase; Lipopolysaccharides; Nitroprusside; Phosphodiesterase Inhibitors; Pulmonary Artery; Theophylline | 1988 |
Positive inotropic effects in isolated ventricular myocardium from non-failing and terminally failing human hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Bucladesine; Calcium; Cardiomyopathy, Dilated; Cardiotonic Agents; Colforsin; Coronary Disease; Female; Histamine; Humans; In Vitro Techniques; Male; Middle Aged; Myocardial Contraction; Papillary Muscles | 1988 |
Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Calcitriol; Cholera Toxin; Colforsin; Dexamethasone; Isoproterenol; Kinetics; Osteoblasts; Osteopontin; Osteosarcoma; Parathyroid Hormone; Peptide Fragments; Rats; RNA, Messenger; Sialoglycoproteins; Teriparatide; Transcription, Genetic; Transforming Growth Factors; Tumor Cells, Cultured | 1989 |
K+ channel and adenylate cyclase involvement in regulation of Ca2+-evoked release of [3H]dopamine from synaptosomes.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Aminopyridines; Animals; Calcium; Colforsin; Dopamine; Ergolines; Ethylmaleimide; In Vitro Techniques; Pertussis Toxin; Potassium Channels; Quinpirole; Rats; Synaptosomes; Tetraethylammonium Compounds; Virulence Factors, Bordetella | 1989 |
Growth hormone release from chicken anterior pituitary cells in primary culture: TRH and hpGRF synergy, protein synthesis, and cyclic adenosine 3'5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Cycloheximide; Drug Synergism; Growth Hormone; Growth Hormone-Releasing Hormone; Pituitary Gland, Anterior; Protein Biosynthesis; Thyrotropin-Releasing Hormone | 1989 |
Astrocytes regulate GFAP mRNA levels by cyclic AMP and protein kinase C-dependent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Glial Fibrillary Acidic Protein; Humans; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate | 1988 |
Induction of polyomavirus DNA replication by cyclic AMP and a tumor promoter.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Transformed; Colforsin; Cyclic AMP; Cycloheximide; DNA Replication; Polyomavirus; Protein Biosynthesis; Tetradecanoylphorbol Acetate; Virus Replication | 1988 |
Alpha bag cell peptide reduces stimulated cAMP levels and pro-ELH synthesis in bag cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Colforsin; Cyclic AMP; Dopamine; Invertebrate Hormones | 1988 |
The effect of cyclic AMP on neuritic outgrowth in explant cultures of developing chick olfactory epithelium.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Axons; Bucladesine; Chick Embryo; Colforsin; Cyclic AMP; Epithelial Cells; Neurons; Nose; Organ Culture Techniques; Theophylline | 1988 |
Efferent neurotransmission of circadian rhythms in Limulus lateral eye. II. Intracellular recordings in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Circadian Rhythm; Colforsin; Efferent Pathways; Horseshoe Crabs; In Vitro Techniques; Naphazoline; Octopamine; Photic Stimulation; Photoreceptor Cells; Retina; Synaptic Transmission | 1988 |
The role of cAMP in regulation of electrical activity of the neuroendocrine caudodorsal cells of Lymnaea stagnalis.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Electric Stimulation; Lymnaea; Neurosecretory Systems; Thionucleotides | 1989 |
cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Bucladesine; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Proteins; Muscimol; Rats; Synaptosomes | 1989 |
Beta-adrenergic and prostanoid inhibition of canine fundic mucosal mast cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Animals; Calcimycin; Colforsin; Concanavalin A; Cyclic AMP; Dinoprostone; Dogs; Enprostil; Epinephrine; Gastric Fundus; Gastric Mucosa; Histamine Release; Isoproterenol; Liver; Mast Cells; Propanolamines; Propranolol; Prostaglandins E, Synthetic; Tetradecanoylphorbol Acetate | 1989 |
Cholinergic antagonism of beta-adrenergic stimulated action potentials and adenylate cyclase activity in rabbit ventricular cardiomyocytes.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Bucladesine; Calcium; Colforsin; Heart; Isoproterenol; Male; Myocardium; Parasympathetic Nervous System; Rabbits; Receptors, Muscarinic | 1988 |
Effect of cAMP on ciliary function in rabbit tracheal epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cilia; Colforsin; Cyclic AMP; Epithelium; Furosemide; Kinetics; Male; Organ Culture Techniques; Rabbits; Theophylline; Thionucleotides; Trachea | 1989 |
Stimulation of bile acid active transport related to increased mucosal cyclic AMP content in rat ileum in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bile Acids and Salts; Biological Transport, Active; Colforsin; Cyclic AMP; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Male; Rats; Rats, Inbred Strains; Taurocholic Acid | 1989 |
Nb2 cell mitogenesis: effect of lactogens on cAMP and protein phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Colforsin; Cyclic AMP; DNA; Growth Hormone; Phosphorylation; Placental Lactogen; Prolactin; Protein Biosynthesis; Proteins; RNA; Tumor Cells, Cultured | 1989 |
Mitogenic activity of phorbol esters and insulin-like growth factor 1 in chemically transformed mouse fibroblasts BP-A31: independent effects and differential sensitivity to inhibition by 3-isobutyl-1-methyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cell Division; Cell Transformation, Neoplastic; Colforsin; Cyclic AMP; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Insulin; Insulin-Like Growth Factor I; Mice; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Somatomedins; Suramin; Tetradecanoylphorbol Acetate; Theophylline | 1989 |
Cyclic nucleotides regulate collagen production by human intestinal smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Collagen; Cyclic AMP; Dibutyryl Cyclic GMP; Humans; Intestinal Mucosa; Jejunum; Muscle, Smooth | 1989 |
Muscarinic M2 stimulation releases histamine in the totally isolated, vascularly perfused rat stomach.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Electric Stimulation; Gastric Acid; Gastric Mucosa; Histamine Release; Male; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Vagus Nerve | 1988 |
Phorbol-12,13-dibutyrate antagonizes while forskolin potentiates the presynaptic autoreceptor-mediated inhibition of [3H]-5-hydroxytryptamine release in rat hypothalamic slices.
Topics: 1-Methyl-3-isobutylxanthine; 5-Methoxytryptamine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Drug Interactions; Drug Synergism; Electric Stimulation; Evoked Potentials; Hypothalamus; Indoles; Male; Methiothepin; Phorbol 12,13-Dibutyrate; Phorbol Esters; Polymyxin B; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Differential vagal inhibition of the positive chronotropic and inotropic responses to cardiotonics in the isolated dog atrium.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cardiotonic Agents; Colforsin; Dobutamine; Dogs; Electric Stimulation; Heart; Heart Rate; In Vitro Techniques; Myocardial Contraction; Norepinephrine; Vagus Nerve | 1989 |
Cyclic AMP as a negative regulator of DNA synthesis in FRSK cells, a fetal rat epidermal cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; DNA; Epidermal Cells; Phosphodiesterase Inhibitors; Rats | 1989 |
Cyclic AMP-dependent melatonin production in Y79 human retinoblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 5-Hydroxytryptophan; 8-Bromo Cyclic Adenosine Monophosphate; Colforsin; Cyclic AMP; Humans; Melatonin; Middle Aged; Retinoblastoma; Tumor Cells, Cultured | 1989 |
Regulation of osteosarcoma EGF receptor affinity by phorbol ester and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Osteosarcoma; Parathyroid Hormone; Tetradecanoylphorbol Acetate | 1989 |
Activation of the beta 2-adrenergic receptor promotes growth and differentiation in thyroid cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cell Division; Cell Line; Colforsin; Cyclic AMP; DNA Replication; Humans; Iodides; Isoproterenol; Rats; Receptors, Adrenergic, beta; Thyroid Gland; Thyrotropin; Transfection | 1989 |
Effect of rise in cAMP levels on Ca2+ influx through voltage-dependent Ca2+ channels in HIT cells. Second-messenger synarchy in beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzofurans; Calcium; Calcium Channels; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; Electrophysiology; Fura-2; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Second Messenger Systems; Verapamil | 1989 |
Rapid dephosphorylation of protein kinase C substrates by protein kinase A activators results from inhibition of diacylglycerol release.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Bradykinin; Brain; Bucladesine; Colforsin; Cricetinae; Diglycerides; Enzyme Activation; Glycerides; Hybrid Cells; Inositol Phosphates; Kinetics; Mice; Molecular Weight; Neuroblastoma; Phosphates; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Fura 2 analysis of cytosolic calcium regulation in elutriated rat gastric parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzofurans; Calcium; Carbachol; Colforsin; Cytosol; Fluorescent Dyes; Fura-2; Histamine; Homeostasis; In Vitro Techniques; Kinetics; Male; Molecular Weight; Parietal Cells, Gastric; Phosphoproteins; Phosphorylation; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1989 |
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Cell Membrane; Colforsin; Cricetinae; Cyclic AMP; Epinephrine; Genes; Glioma; Kinetics; Rats; Receptors, Adrenergic, beta; RNA, Messenger; Tetradecanoylphorbol Acetate; Theophylline; Transcription, Genetic | 1989 |
Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. I. Studies with fluoride.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Arteries; Bucladesine; Calcium; Calcium Channels; Colforsin; Cyclic AMP; Cyclic GMP; GTP-Binding Proteins; In Vitro Techniques; Inositol Phosphates; Kinetics; Male; Muscle, Smooth, Vascular; Nifedipine; Potassium Chloride; Rats; Rats, Inbred Strains; Sodium Fluoride; Vasoconstriction; Verapamil | 1989 |
Guanine nucleotide binding proteins may modulate gating of calcium channels in vascular smooth muscle. II. Studies with guanosine 5'-(gamma)triphosphate.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Arteries; Bucladesine; Calcium; Calcium Channels; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Kinetics; Male; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Rats; Rats, Inbred Strains; Thionucleotides; Vasoconstriction | 1989 |
Insulin enhances luteinizing hormone-stimulated steroidogenesis by porcine theca cells.
Topics: 1-Methyl-3-isobutylxanthine; Androstenedione; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Female; Hydroxycholesterols; Insulin; Insulin-Like Growth Factor I; Kinetics; Luteinizing Hormone; Pregnenolone; Progesterone; Relaxin; Swine; Theca Cells | 1989 |
A comparison of cyclic AMP signaling system in rat aortic myocytes in primary culture and aorta.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Aorta, Thoracic; Cells, Cultured; Colforsin; Cyclic AMP; Isoproterenol; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Vasoactive Intestinal Peptide | 1989 |
Identification of an adenosine 3',5'-monophosphate (cAMP)-responsive region in the rat growth hormone gene: evidence for independent and synergistic effects of cAMP and thyroid hormone on gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Chromosome Deletion; Colforsin; Cyclic AMP; Drug Synergism; Gene Expression Regulation; Genes; Growth Hormone; Molecular Sequence Data; Promoter Regions, Genetic; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Theophylline; Thionucleotides; Transcription, Genetic; Triiodothyronine | 1989 |
Vasoactive intestinal peptide inhibits the respiratory burst in human monocytes by a cyclic AMP-mediated mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Cyclic AMP; Humans; Monocytes; Oxygen Consumption; Peptide PHI; Secretin; Vasoactive Intestinal Peptide | 1989 |
Beta-adrenergic relaxation of dog trachealis: contractile agonist-specific interaction.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adrenergic beta-Agonists; Animals; Bucladesine; Colforsin; Dogs; Histamine; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Serotonin; Trachea | 1989 |
Stathmin is a major phosphoprotein and cyclic AMP-dependent protein kinase substrate in mouse brain neurons but not in astrocytes in culture: regulation during ontogenesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Brain; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Electrophoresis, Gel, Two-Dimensional; Mice; Microtubule Proteins; Neurons; Phosphoproteins; Phosphorylation; Protein Kinases; Stathmin | 1989 |
Renal epithelial cyst formation and enlargement in vitro: dependence on cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Animals; Arginine Vasopressin; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Isoproterenol; Kidney; Kidney Diseases, Cystic; Terbutaline | 1989 |
Two types of chloride channel on duct cells cultured from human fetal pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Electric Conductivity; Electrophysiology; Fetus; Humans; Ion Channels; Kinetics; Membrane Potentials; Membrane Proteins; Pancreatic Ducts; Secretin | 1989 |
Cysteine sulfinic acid-induced release of D-[3H]aspartate and [14C]GABA in hippocampus slices: the role of sodium channels and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids; Animals; Aspartic Acid; Calcium; Cnidarian Venoms; Colforsin; Cysteine; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Neurotoxins; Neurotransmitter Agents; Rats; Sodium Channels; Tetrodotoxin | 1989 |
Increased cyclic AMP content accelerates protein synthesis in rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbon Radioisotopes; Colforsin; Cyclic AMP; Glucagon; Heart; In Vitro Techniques; Insulin; Kinetics; Male; Myocardial Contraction; Myocardium; Perfusion; Phenylalanine; Protein Biosynthesis; Protein Kinases; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Tetrodotoxin; Theophylline | 1989 |
Diminution by benzodiazepines of the chronotropic responses to noradrenaline in rat isolated atria.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Colforsin; Cyclic AMP; Diazepam; Female; Flumazenil; Heart; Heart Rate; In Vitro Techniques; Isoquinolines; Male; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains | 1989 |
Glucagon-induced refractoriness of hepatocyte adenylate cyclase: comparison of homologous and heterologous components and evidence against a role of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Glucagon; Isoproterenol; Liver; Male; Rats; Rats, Inbred Strains | 1989 |
The role of cyclic AMP in the control of elasmobranch ocular tapetum lucidum pigment granule migration.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Choroid; Colforsin; Cyclic AMP; Cytoplasmic Granules; Dark Adaptation; Dogfish; Male; Pigments, Biological; Sharks | 1988 |
Cyclic AMP mediation of the hormonal stimulation of 14C-acetate incorporation by Heliothis armigera pheromone glands in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetates; Aldehydes; Animals; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Colforsin; Cyclic AMP; Female; In Vitro Techniques; Lepidoptera; Pheromones; Sex Attractants; Tissue Extracts | 1989 |
Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; DNA; Fibroblasts; Gene Expression Regulation; Genes; Genetic Vectors; Homeostasis; Humans; Isoproterenol; Kinetics; Mutation; Phosphorylation; Receptors, Adrenergic, beta; RNA, Messenger; Theophylline; Transcription, Genetic; Transfection | 1989 |
Vasoactive intestinal polypeptide and alpha 2-adrenoceptor agonists regulate adenosine 3',5'-monophosphate accumulation and melatonin release in chick pineal cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Brimonidine Tartrate; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Kinetics; Melatonin; Molecular Sequence Data; Pineal Gland; Quinoxalines; Radioimmunoassay; Sequence Homology, Nucleic Acid; Structure-Activity Relationship; Vasoactive Intestinal Peptide | 1989 |
Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Animals; Cell Line; Cholera Toxin; Clone Cells; Colforsin; Cyclic AMP; Down-Regulation; GTP-Binding Proteins; Kinetics; Osteosarcoma; Parathyroid Hormone; Peptide Fragments; Pertussis Toxin; Rats; Receptors, Cell Surface; Receptors, Parathyroid Hormone; Teriparatide; Theophylline; Virulence Factors, Bordetella | 1989 |
Adenosine has divergent effects on deoxyribonucleic acid synthesis in FRTL5 cells: inhibition of thyrotropin-stimulated and potentiation of insulin-like growth factor-I-stimulated thymidine incorporation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase; Animals; Bucladesine; Cell Line; Cholera Toxin; Colforsin; DNA; DNA Replication; Drug Synergism; Insulin-Like Growth Factor I; Kinetics; Somatomedins; Thymidine; Thyroid Gland; Thyrotropin | 1989 |
Reduced early and late phase insulin response to glucose in isolated spiny mouse (Acomys cahirinus) islets: a defective link between glycolysis and adenylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Female; Glucagon; Glucose; Glycolysis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Muridae; Rats; Rats, Inbred Strains | 1989 |
Muscarinic receptor-stimulated phosphoinositide turnover in human SK-N-SH neuroblastoma cells: differential inhibition by agents that elevate cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alprostadil; Bucladesine; Carbachol; Cholera Toxin; Colforsin; Cyclic AMP; Humans; Intracellular Membranes; Ligands; Neuroblastoma; Phosphatidylinositols; Receptors, Muscarinic; Theophylline; Tumor Cells, Cultured | 1989 |
A study of the phasic response of arterioles of the guinea pig small intestine to prolonged exposure to norepinephrine.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arterioles; Clonidine; Colforsin; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Intestine, Small; Isoproterenol; Membrane Potentials; Norepinephrine; Oxidation-Reduction; Propranolol; Temperature; Theophylline; Vasoconstriction; Yohimbine | 1989 |
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Antigens, Differentiation; Bucladesine; Cell Adhesion; Cell Adhesion Molecules; Colforsin; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Micelles; Phorbol Esters; Receptors, Antigen, T-Cell; Receptors, Leukocyte-Adhesion; Staurosporine; T-Lymphocytes; Temperature | 1989 |
Inhibitory modulation by cAMP of isoproterenol-induced prostacyclin synthesis in rabbit heart.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 6-Ketoprostaglandin F1 alpha; Adenylyl Cyclase Inhibitors; Animals; Blood Pressure; Colforsin; Cyclic AMP; Epoprostenol; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardium; Phenylisopropyladenosine; Platelet Aggregation Inhibitors; Quinolones; Rabbits; Thionucleotides | 1989 |
Evidence that monensin inhibits vasopressin-stimulated water flow at an early step in the receptor-adenylate cyclase sequence.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Body Water; Bufo marinus; Colforsin; In Vitro Techniques; Kinetics; Monensin; Naproxen; Receptors, Angiotensin; Receptors, Vasopressin; Urinary Bladder; Vasopressins | 1989 |
Second-messenger systems underlying amine and peptide actions on cardiac muscle in the horseshoe crab Limulus polyphemus.
Topics: 1-Methyl-3-isobutylxanthine; Amines; Animals; Catecholamines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Epinephrine; Heart; Horseshoe Crabs; Myocardial Contraction; Neuropeptides; Norepinephrine; Oligopeptides; Peptides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Second Messenger Systems | 1989 |
Secretagogues increase apical membrane conductance of isolated bullfrog corneal epithelium pretreated with loop diuretics.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Bumetanide; Chlorides; Colforsin; Cornea; Dinoprostone; Diuretics; Epithelium; Furosemide; In Vitro Techniques; Membrane Potentials; Rana catesbeiana | 1989 |
Copia RNA levels are elevated in dunce mutants and modulated by cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Monophosphate; Animals; Cloning, Molecular; Colforsin; Cyclic AMP; DNA Probes; DNA Transposable Elements; Drosophila melanogaster; Gene Expression; Mutation; Restriction Mapping; RNA | 1989 |
Studies of glucocorticoid enhancement of the capacity of hepatocytes to accumulate cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cycloheximide; Dexamethasone; Glucagon; Glucocorticoids; Isoproterenol; Kinetics; Liver; Male; Methylprednisolone; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains | 1989 |
Aging of rat heart myocytes disrupts muscarinic receptor coupling that leads to inhibition of cAMP accumulation and alters the pathway of muscarinic-stimulated phosphoinositide hydrolysis.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Binding, Competitive; Carbachol; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Heart; Isoproterenol; Kinetics; Myocardium; Norepinephrine; Oxotremorine; Phosphatidylinositols; Rats; Receptors, Muscarinic; Time Factors | 1989 |
Phosphorylation of phospholipase C-gamma by cAMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Amino Acids; Animals; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Glioma; Isoenzymes; Kinetics; Phosphorylation; Protein Kinases; Rats; Tumor Cells, Cultured; Type C Phospholipases | 1989 |
Involvement of adenylate cyclase and protein kinase C in the alpha 2-adrenoceptor-mediated inhibition of noradrenaline and 5-hydroxytryptamine release in rat hypothalamic slices.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Antihypertensive Agents; Brimonidine Tartrate; Colforsin; Dioxanes; Electric Stimulation; Hypothalamus; Idazoxan; In Vitro Techniques; Male; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin | 1989 |
Regulation of GH3 pituitary tumour-cell adenylate cyclase activity by activators of protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Bombesin; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Oxotremorine; Phorbol 12,13-Dibutyrate; Pituitary Neoplasms; Protein Kinase C; Tumor Cells, Cultured; Type C Phospholipases; Vasoactive Intestinal Peptide | 1989 |
Agents affecting adenylate cyclase activity modulate the stimulatory action of 1,25-dihydroxyvitamin D3 on the production of osteocalcin by human bone cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaline Phosphatase; Bone and Bones; Bucladesine; Calcitriol; Cells, Cultured; Colforsin; Humans; Interleukin-1; Kinetics; Osteoblasts; Osteocalcin; Phorbols; Recombinant Proteins; Theophylline | 1989 |
Inhibitory effect of cyclic AMP on phorbol ester-stimulated production of reactive oxygen metabolites in rat glomeruli.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Kidney Glomerulus; Kinetics; Luminescent Measurements; Male; Oxygen; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Theophylline | 1989 |
Regulation of prostaglandin endoperoxide synthase by cyclic adenosine 3',5'-monophosphate in the in vitro-perfused rat ovary.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cytochrome P-450 Enzyme System; Estradiol; Female; Granulosa Cells; Intramolecular Oxidoreductases; Isomerases; Luteinizing Hormone; Ovary; Ovulation; Progesterone; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Testosterone; Time Factors | 1989 |
Cyclic AMP regulation of P0 glycoprotein and myelin basic protein gene expression in semi-differentiated peripheral neurinoma cell line D6P2T.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Aggregation; Cell Division; Colforsin; Cyclic AMP; Gene Expression Regulation; Immunoblotting; Kinetics; Myelin Basic Protein; Myelin P0 Protein; Myelin Proteins; Neurilemmoma; Nucleic Acid Hybridization; RNA; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Renal epithelial fluid secretion and cyst growth: the role of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Animals; Body Fluids; Cell Line; Colforsin; Cyclic AMP; Dogs; Epithelium; Humans; Kidney; Kidney Diseases, Cystic; Rats | 1989 |
Adenylate cyclase system is essential for long-term facilitation at the crayfish neuromuscular junction.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Astacoidea; Bacterial Toxins; Colforsin; Cyclic AMP; GTP-Binding Proteins; Mopidamol; Neuromuscular Junction; Phospholipases; Protein Kinase Inhibitors; Time Factors | 1989 |
Effects of the phosphodiesterase inhibitor enoximone on the autonomic innervation of the isolated heart.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Autonomic Nervous System; Chickens; Colforsin; Electric Stimulation; Enoximone; Guinea Pigs; Heart; Heart Rate; Imidazoles; In Vitro Techniques; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors | 1989 |
Hyperthyroid adult rat cardiomyocytes. I. Nucleotide content, beta- and alpha-adrenoreceptors, and cAMP production.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; AMP Deaminase; Animals; Binding Sites; Colforsin; Cyclic AMP; Enzyme Activation; Hyperthyroidism; Myocardium; Nucleotides; Phenylephrine; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1989 |
Neuropeptide Y-induced intracellular Ca2+ increases in vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Bradykinin; Calcium; Cells, Cultured; Colforsin; Cytoplasm; GTP-Binding Proteins; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth, Vascular; Neuropeptide Y; Pertussis Toxin; Receptors, Neuropeptide Y; Receptors, Neurotransmitter; Swine; Virulence Factors, Bordetella | 1989 |
Model of prostaglandin-regulated cyclic AMP metabolism in intact platelets: examination of time-dependent effects on adenylate cyclase and phosphodiesterase activities.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Blood Platelets; Colforsin; Computer Simulation; Cyclic AMP; Epoprostenol; GTP-Binding Proteins; Humans; Iloprost; Prostaglandins E; Time Factors | 1989 |
Inhibition of DNA synthesis of adult rat hepatocytes in primary culture by dibutyrylcytidine 3', 5'-cyclic monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic CMP; Cytosine Nucleotides; DNA Replication; Liver; Male; Rats; Rats, Inbred Strains | 1989 |
Potassium currents in submucous neurones of guinea-pig caecum and their synaptic modification.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Animals; Calcium; Cecum; Colforsin; Cyclic AMP; Guinea Pigs; Membrane Potentials; Neurons; Potassium; Tachykinins; Tetraethylammonium; Tetraethylammonium Compounds | 1989 |
The regulation of glucose transporter gene expression by cyclic adenosine monophosphate in NIH3T3 fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anisomycin; Biological Transport, Active; Cholera Toxin; Colforsin; Cyclic AMP; Fibroblasts; Gene Expression Regulation; Glucose; In Vitro Techniques; Monosaccharide Transport Proteins; Protein Kinase C; Rats; RNA; Tetradecanoylphorbol Acetate | 1989 |
Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cerebral Cortex; Colforsin; Cyclic AMP; Female; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Kinetics; Lithium; Male; Mice; Receptors, Purinergic; Second Messenger Systems; Xanthines | 1989 |
Inhibition by salbutamol, forskolin and IBMX of AlF4-induced inositol phosphate formation in bovine airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Albuterol; Aluminum; Aluminum Compounds; Animals; Cattle; Colforsin; Fluorides; In Vitro Techniques; Inositol Phosphates; Muscle, Smooth; Theophylline; Trachea | 1989 |
Altered release of growth hormone from dispersed adenohypophysial cells of streptozotocin diabetic rats. II. Effects of a phorbol ester and secretagogues which increase cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Somatostatin; Tetradecanoylphorbol Acetate | 1989 |
Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.
Topics: 1-Methyl-3-isobutylxanthine; Binding Sites; Blotting, Western; Calcimycin; Cell Differentiation; Colforsin; Cyclic AMP; DNA Probes; DNA-Binding Proteins; Gene Expression Regulation; Humans; Plasmids; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transcription Factors; Transcription, Genetic; Transfection; Tretinoin | 1989 |
Fibroblast contractility and actin organization are stimulated by microtubule inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Cell Movement; Colforsin; Demecolcine; Fibroblasts; Mice; Mice, Inbred Strains; Microscopy, Fluorescence; Microtubules; Nocodazole; Paclitaxel; Photomicrography; Tetradecanoylphorbol Acetate; Vinblastine | 1989 |
Potentiation of the effects of dopamine in the rabbit isolated splenic artery by 3-isobutyl-1-methylxanthine or forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Benzopyrans; Colforsin; Cromakalim; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Male; Parasympatholytics; Purinergic Antagonists; Purinones; Pyrroles; Rabbits; Splenic Artery; Theophylline | 1989 |
Serotonin augments the cationic current Ih in central neurons.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Cations; Colforsin; Hypoglossal Nerve; Ion Channel Gating; Ion Channels; Male; Medulla Oblongata; Neurons; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Twenty-four hour oscillation of cAMP in chick pineal cells: role of cAMP in the acute and circadian regulation of melatonin production.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Chickens; Circadian Rhythm; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Male; Melatonin; Pineal Gland | 1989 |
Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Drug Synergism; Fluorescence; Humans; Interleukin-1; Leukemia; Prostaglandins E; Receptors, Interleukin-2; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1989 |
3',5'-cyclic adenosine monophosphate as an intracellular second messenger of luteinizing hormone: application of the forskolin criteria.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cholera Toxin; Chorionic Gonadotropin; Colforsin; Culture Techniques; Cyclic AMP; Hypophysectomy; Luteinizing Hormone; Male; Rats; Rats, Inbred Strains; Receptors, LH; Signal Transduction; Testis; Testosterone | 1986 |
Circadian change in function of Limulus ventral photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Circadian Rhythm; Colforsin; Cyclic AMP; Electroretinography; Horseshoe Crabs; Light; Microelectrodes; Octopamine; Photoreceptor Cells | 1988 |
Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animals; Biopterins; Cell Line; Colforsin; Cycloheximide; Dihydropteridine Reductase; GTP Cyclohydrolase; Isoenzymes; Kinetics; Pheochromocytoma; Pteridines; Pterins; Rats; Reserpine; Theophylline | 1989 |
Electrical activity, cAMP concentration, and insulin release in mouse islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Diterpenes; Electric Conductivity; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Membrane Potentials; Mice | 1985 |
Arachidonic acid metabolism in cultured aortic endothelial cells. Effect of cAMP and 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Endothelium; Epoprostenol; Muscle, Smooth, Vascular; Swine; Theophylline | 1985 |
Evidence for a role for adenosine 3',5'-monophosphate in progesterone secretion by human chorion.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cholera Toxin; Chorion; Colforsin; Cyclic AMP; Diterpenes; Female; Humans; Hydroxycholesterols; In Vitro Techniques; Kinetics; Pregnancy; Pregnenolone; Progesterone; Serum Albumin, Bovine | 1985 |
Morphological and biochemical responses of cultured thyroid cells to thyrotropin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cytoskeleton; Diterpenes; Dogs; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Microtubules; Thyroid Gland; Thyrotropin; Time Factors | 1985 |
1,25-Dihydroxycholecalciferol and glucocorticosteroid regulation of adenylate cyclase in an osteoblast-like cell line.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcitriol; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Glucocorticoids; Guanylyl Imidodiphosphate; Isoproterenol; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Time Factors; Triamcinolone Acetonide | 1985 |
beta-Adrenergic induced K+ current in Xenopus oocytes: role of cAMP, inhibition by muscarinic agents.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenosine; Aminobenzoates; Aminopyridines; Animals; Atropine; Calcimycin; Colforsin; Cyclic AMP; Diterpenes; Female; Isoproterenol; Oocytes; Phosphodiesterase Inhibitors; Potassium; Receptors, Adrenergic, beta; Tetraethylammonium Compounds; Xenopus laevis | 1985 |
GABAB receptor modulation of adenylate cyclase activity in rat brain slices.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Baclofen; Brain; Cerebral Cortex; Colforsin; Cyclic AMP; Diterpenes; gamma-Aminobutyric Acid; In Vitro Techniques; Nipecotic Acids; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Dopamine inhibits forskolin- and 3-isobutyl-1-methylxanthine-induced dark-adaptive retinomotor movements in isolated teleost retinas.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Dark Adaptation; Diterpenes; Dopamine; Fishes; In Vitro Techniques; Pigment Epithelium of Eye; Retina; Theophylline | 1985 |
Effect of phosphodiesterase inhibitors on bradykinin-mediated prostaglandin E2 and cyclic AMP synthesis in renal papillary collecting tubule cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Colforsin; Cyclic AMP; Dinoprostone; Diterpenes; In Vitro Techniques; Kidney Medulla; Kidney Tubules; Kidney Tubules, Collecting; Male; Phosphodiesterase Inhibitors; Prostaglandins E; Rabbits | 1985 |
Forskolin, an activator of adenylate cyclase, stimulates pancreatic insulin, glucagon, and somatostatin release in the dog: studies in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Atropine; Calcium; Colforsin; Diterpenes; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Pancreas; Phentolamine; Propranolol; Somatostatin | 1985 |
Involvement of calcium in the release of immunoreactive beta-endorphin-like peptide from dispersed cells of the neurointermediate lobe of the rat pituitary gland.
Topics: 1-Methyl-3-isobutylxanthine; Animals; beta-Endorphin; Bucladesine; Calcimycin; Calcium; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Endorphins; In Vitro Techniques; Isoproterenol; Pituitary Gland; Rats; Theophylline; Verapamil | 1985 |
Forskolin increases cAMP and inhibits progesterone induced meiosis reinitiation in Xenopus laevis oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Diterpenes; Female; Meiosis; Oocytes; Ovum; Progesterone; Xenopus laevis | 1982 |
Somatocrinin (growth hormone releasing factor) in vitro bioactivity; Ca++ involvement, cAMP mediated action and additivity of effect with PGE2.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antihypertensive Agents; Calcium; Cholera Toxin; Cobalt; Colforsin; Cyclic AMP; Dinoprostone; Diterpenes; Growth Hormone; Growth Hormone-Releasing Hormone; Hypothalamus; Kinetics; Peptide Fragments; Pituitary Gland; Prostaglandins E; Radioimmunoassay; Rats; Somatostatin | 1982 |
Prostacyclin biosynthesis in vascular endothelium is not inhibited by cyclic AMP. Studies with 3-isobutyl-1-methylxanthine and forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Epoprostenol; Humans; Isoproterenol; Prostaglandin Antagonists; Prostaglandins; Stimulation, Chemical; Theophylline; Umbilical Veins | 1982 |
Regulation of mouse oocyte meiotic maturation: implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Diterpenes; Female; Meiosis; Mice; Oocytes; Ovum; Phosphoproteins; Phosphorylation; Proteins; Radioimmunoassay | 1983 |
Regulation of adenylate cyclase in cultured cardiocytes from neonatal rats by adenosine and other agonists.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Animals, Newborn; Catecholamines; Cells, Cultured; Colforsin; Diterpenes; Enzyme Activation; Guanosine Triphosphate; Microscopy, Electron; Myocardium; Rats; Receptors, Cell Surface; Receptors, Purinergic | 1983 |
Inhibition of denuded mouse oocyte meiotic maturation by forskolin, an activator of adenylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Enzyme Activation; Female; Meiosis; Mice; Oocytes; Ovum | 1983 |
Forskolin activates adenylate cyclase activity and inhibits mitosis in in vitro in pig epidermis.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Enzyme Activation; Epidermal Cells; Epidermis; Mitosis; Skin; Swine | 1983 |
Inhibition of oocyte maturation in the mouse: participation of cAMP, steroid hormones, and a putative maturation-inhibitory factor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Female; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Mice; Mice, Inbred C57BL; Oocytes; Progesterone; Testosterone | 1983 |
The regulation of glucose transport by cAMP stimulators via three different mechanisms in rat and human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3-O-Methylglucose; Adipose Tissue; Animals; Bucladesine; Carrier Proteins; Cell Membrane; Colforsin; Cyclic AMP; Diterpenes; Glucose; Humans; Insulin; Isoproterenol; Kinetics; Male; Methylglucosides; Monosaccharide Transport Proteins; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Effect of thyrotropin-releasing hormone on dog thyroid in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alprostadil; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Dogs; In Vitro Techniques; Iodides; Kinetics; Prostaglandins E; Thyroid Gland; Thyrotropin; Thyrotropin-Releasing Hormone | 1983 |
Effects of forskolin on progesterone and cyclic adenosine monophosphate production in avian granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chickens; Colforsin; Cyclic AMP; Diterpenes; Female; Granulosa Cells; Luteinizing Hormone; Progesterone | 1983 |
Unexpected potentiation of insulin release by the calcium store blocker TMB-8.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Gallic Acid; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Rats; Rats, Inbred Strains | 1984 |
Cyclic adenosine monophosphate and ovarian follicular fluid act synergistically to inhibit mouse oocyte maturation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Diterpenes; Female; Follicle Stimulating Hormone; Mice; Mice, Inbred Strains; Oocytes; Ovarian Follicle; Swine; Theophylline | 1984 |
Independent effects of bradykinin on adenosine 3',5'-monophosphate and prostaglandin E2 metabolism by rabbit renal medulla.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Colforsin; Cyclic AMP; Dinoprostone; Diterpenes; In Vitro Techniques; Kidney Medulla; Kinetics; Prostaglandins E; Rabbits | 1984 |
Forskolin inhibits tension development in detergent-treated cardiac muscle fibers.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Cardiotonic Agents; Colforsin; Cyclic AMP; Detergents; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Myocardial Contraction; Polyethylene Glycols; Troponin; Troponin I | 1984 |
Regulation of thromboplastin synthesis in mouse placental cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Depression, Chemical; Dinoprostone; Diterpenes; Epinephrine; Female; In Vitro Techniques; Mice; Placenta; Pregnancy; Prostaglandins E; Stimulation, Chemical; Thromboplastin | 1983 |
Stimulation of cAMP accumulation and lipolysis in hamster adipocytes with forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Antihypertensive Agents; Colforsin; Cricetinae; Cyclic AMP; Diterpenes; Isoproterenol; Kinetics; Lipolysis; Mesocricetus; Phenylisopropyladenosine | 1984 |
Adenosine 3',5'-cyclic monophosphate-dependent release of prolactin from GH3 pituitary tumour cells. A quantitative analysis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Dose-Response Relationship, Drug; Pituitary Neoplasms; Prolactin; Rats; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 1983 |
Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Diterpenes; Glioma; Isoproterenol; Neoplasm Proteins; Protein Biosynthesis; Rats | 1983 |
Pertussis toxin actions on the pituitary-derived 235-1 clone: effects of PGE1, cholera toxin, and forskolin on cyclic AMP metabolism and prolactin release.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Bacterial Toxins; Cells, Cultured; Cholera Toxin; Clone Cells; Colforsin; Cyclic AMP; Diterpenes; Male; Pertussis Toxin; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Prostaglandins E; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1983 |
Cyclic adenosine monophosphate regulates vasoactive intestinal polypeptide and enkephalin biosynthesis in cultured bovine chromaffin cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Medulla; Animals; Bucladesine; Cardiotonic Agents; Cattle; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Enkephalins; Kinetics; Vasoactive Intestinal Peptide | 1983 |
Calmodulin and cyclic AMP. Possible different sites of action of these two regulatory agents in exocytotic hormone release.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calmodulin; Colforsin; Cyclic AMP; Diterpenes; Exocytosis; Glucagon; Glucose; Hormones; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Somatostatin; Somatostatin | 1984 |
Forskolin and the release of noradrenaline in cerebrocortical slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cerebral Cortex; Cocaine; Colforsin; Cyclic AMP; Diterpenes; Electric Stimulation; Female; In Vitro Techniques; Kidney; Male; Norepinephrine; Rabbits; Rats; Renin | 1984 |
A modulatory octopaminergic neurone increases cyclic nucleotide levels in locust skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Amines; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Electric Stimulation; Female; Grasshoppers; Male; Muscles; Neuromuscular Junction; Octopamine; Stereoisomerism; Stimulation, Chemical | 1984 |
The role of cyclic nucleotides and calcium in the mediation of the modulatory effects of octopamine on locust skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Cyclic AMP; Diterpenes; Female; Grasshoppers; Male; Membrane Potentials; Motor Endplate; Muscles; Nucleotides, Cyclic; Octopamine; Receptors, Adrenergic; Receptors, Biogenic Amine | 1984 |
cAMP-mediated regulation of chloride secretion by the opercular epithelium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biomechanical Phenomena; Chlorides; Colforsin; Cyclic AMP; Diterpenes; Electric Conductivity; Epithelium; Female; Fishes; Killifishes; Male; Sympathomimetics | 1984 |
Clomiphene and tamoxifen inhibit progesterone synthesis in granulosa cells: comparison with estradiol.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chickens; Clomiphene; Colforsin; Diterpenes; Estradiol; Female; Granulosa Cells; Kinetics; Progesterone; Tamoxifen | 1984 |
Modulation of renal ATPase activities by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphatases; Animals; Bucladesine; Ca(2+) Mg(2+)-ATPase; Colforsin; Cyclic AMP; Diterpenes; Isoproterenol; Kidney; Kidney Cortex; Kidney Medulla; Kinetics; Male; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase | 1984 |
Inhibitory actions of adenosine on follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Dipyridamole; Diterpenes; Female; Follicle Stimulating Hormone; Granulosa Cells; Rats; Receptors, Cell Surface; Receptors, LH | 1984 |
LHRH agonist decreases LH- but not forskolin-stimulated cyclic AMP levels in rat Leydig cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cycloheximide; Diterpenes; Gonadotropin-Releasing Hormone; Goserelin; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Rats; Testosterone | 1984 |
Studies on the mode of action of octopamine, 5-hydroxytryptamine and proctolin on a myogenic rhythm in the locust.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Cyclic AMP; Diterpenes; Grasshoppers; Muscles; Neuropeptides; Nucleotides, Cyclic; Octopamine; Oligopeptides; Periodicity; Phosphodiesterase Inhibitors; Potassium; Receptors, Cell Surface; Serotonin; Sodium | 1984 |
Cyclic nucleotide-dependent enzyme secretion in the rat lacrimal gland.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Carbachol; Cardiotonic Agents; Colforsin; Cyclic GMP; Diterpenes; In Vitro Techniques; Isoenzymes; Lacrimal Apparatus; Male; Peroxidase; Peroxidases; Rats; Rats, Inbred Strains; Stimulation, Chemical; Time Factors | 1984 |
Forskolin and phosphodiesterase inhibitors stimulate rat granulosa cell differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 20-alpha-Dihydroprogesterone; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Estrogens; Female; Follicle Stimulating Hormone; Granulosa Cells; Progesterone; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, LH; Theophylline | 1984 |
3',5'-cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenylyl Cyclases; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic GMP; Diterpenes; Fluorides; Horseshoe Crabs; In Vitro Techniques; Light; Photoreceptor Cells; Time Factors; Vanadates; Vanadium | 1984 |
Forskolin inhibits histamine release by neurotensin in the rat perfused hind limb.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Diterpenes; Hindlimb; Histamine Release; Male; Neurotensin; Perfusion; Rats; Rats, Inbred Strains | 1984 |
Stimulation of acetylcholine release from guinea-pig ileal synaptosomes by cyclic nucleotides and forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Antihypertensive Agents; Calcium; Colforsin; Dimethylphenylpiperazinium Iodide; Diterpenes; Guinea Pigs; Ileum; In Vitro Techniques; Myenteric Plexus; Nucleotides, Cyclic; Synaptosomes; Tritium | 1984 |
Forskolin-induced activation of adenylate cyclase, cyclic adenosine monophosphate production and insulin release in rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Colforsin; Cyclic AMP; Diterpenes; Glucose; Glycolysis; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Rats | 1984 |
Forskolin perturbs cGMP as well as cAMP levels in human thyroid cells.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Diterpenes; Humans; Phosphodiesterase Inhibitors; Thyroid Gland; Thyrotropin | 1984 |
Histone and high mobility group protein phosphorylation in the thyroid: regulation by cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cattle; Colforsin; Diterpenes; High Mobility Group Proteins; Histones; Nucleotides, Cyclic; Phosphorylation; Sodium Nitrite; Thyroid Gland | 1984 |
The role of cyclic AMP in the regulation of ecdysone synthesis.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Dibutyryl Cyclic GMP; Diterpenes; Ecdysone; Insect Hormones; Larva; Lepidoptera | 1984 |
Mechanism of regulation of amylase release by alpha- and beta-adrenergic agonists in rat parotid tissue.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Amylases; Animals; Biomechanical Phenomena; Bucladesine; Colforsin; Cyclic AMP; Diterpenes; Dose-Response Relationship, Drug; Male; Parotid Gland; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1984 |
Mechanisms of synergism between glucose and cAMP on stimulation of insulin release.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biomechanical Phenomena; Calcium; Carbachol; Choline; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Glucose; Insulin; Ion Exchange; Islets of Langerhans; Isotonic Solutions; Male; Ouabain; Potassium Chloride; Rats; Rats, Inbred Strains; Ringer's Solution; Sodium; Stimulation, Chemical; Verapamil | 1984 |
Cholecystokinin-stimulated enzyme secretion from dispersed rabbit pancreatic acinar cells: phosphorylation-dependent changes in potency and efficacy.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Amylases; Animals; Calcium-Transporting ATPases; Cells, Cultured; Cholecystokinin; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Pancreas; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Sincalide; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Time Factors | 1995 |
PGE2 induces the transition from non-adherent to adherent bone marrow mesenchymal precursor cells via a cAMP/EP2-mediated mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Marrow; Bone Marrow Cells; Bucladesine; Cell Adhesion; Cells, Cultured; Colforsin; Colony-Forming Units Assay; Cyclic AMP; Dexamethasone; Dinoprostone; Female; Hematopoietic Stem Cells; Kinetics; Phosphodiesterase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Receptors, Prostaglandin E; Tetradecanoylphorbol Acetate | 1995 |
Regulation of fluid-phase endocytosis in alveolar macrophages.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dextrans; Endocytosis; Fluorescein-5-isothiocyanate; Intracellular Membranes; Macrophages, Alveolar; Male; Rabbits | 1995 |
Interleukin-1 beta independently stimulates production of prostaglandin E2 and cyclic AMP from human decidual cells.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Cyclic AMP; Decidua; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Interleukin-1 | 1995 |
Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cattle; Cells, Cultured; Cholesterol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Fibroblasts; Humans; Kinetics; Mevalonic Acid; Skin; Sterols; Tetranitromethane; Theophylline; Thionucleotides | 1993 |
Protein kinase regulation of tumor necrosis factor alpha stimulated collagenase and stromelysin message levels in chondrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cartilage, Articular; Cell Membrane; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Enzyme Induction; Gene Expression Regulation; Isoquinolines; Kinetics; Matrix Metalloproteinase 3; Metalloendopeptidases; Neoplasm Proteins; Piperazines; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Noradrenergic regulation of c-jun expression in the rat pineal gland in culture: positive and negative components.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Gene Expression Regulation; Isoquinolines; Male; Norepinephrine; Organ Culture Techniques; Phorbol 12,13-Dibutyrate; Pineal Gland; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; RNA, Messenger; Sulfonamides | 1993 |
The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-kappa B in human T-cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; Cytotoxicity, Immunologic; Gene Products, tax; Human T-lymphotropic virus 1; Humans; Lymphotoxin-alpha; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; T-Lymphocytes; Transfection; Tumor Cells, Cultured | 1993 |
Alterations in the cyclic AMP signal transduction pathway regulating ribonucleotide reductase gene expression in malignant H-ras transformed cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Transformed; Colforsin; Cyclic AMP; Cycloheximide; Fibroblasts; Gene Expression Regulation; Genes, ras; Mice; Protein Kinase C; Ribonucleotide Reductases; S Phase; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Calcitonin induces a decreased Na+ conductance in identified neurons of Aplysia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Calcitonin; Calcium; Colforsin; Cyclic AMP; Diglycerides; Ganglia, Invertebrate; Indomethacin; Masoprocol; Membrane Potentials; Microinjections; Naphthalenes; Neurons; Polycyclic Compounds; Potassium; Protein Kinase C; Sodium; Sodium Channels | 1993 |
Increased platelet reactivity to prostaglandin E1 in hypertension is linked with altered signal transduction.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Blood Platelets; Colforsin; Cyclic AMP; GTP Phosphohydrolases; Hypertension; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction | 1993 |
Histamine H3-receptor-induced inhibition of duodenal cholinergic transmission is independent of intracellular cyclic AMP and GMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Clonidine; Colforsin; Cyclic AMP; Cyclic GMP; Duodenum; Guinea Pigs; Histamine Agonists; In Vitro Techniques; Male; Methylhistamines; Parasympathetic Nervous System; Receptors, Histamine H3; Signal Transduction; Synaptic Transmission | 1993 |
Phosphorylation-regulated low-conductance Cl- channels in a human pancreatic duct cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Alkaline Phosphatase; Anions; Biological Transport; Bucladesine; Cell Line; Cell Membrane; Chloride Channels; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electric Conductivity; Humans; Pancreatic Ducts; Phosphorylation; Vasoactive Intestinal Peptide | 1993 |
Serotonin and acetylcholine: further analysis of praziquantel-induced contraction of magnesium-paralysed Schistosoma mansoni.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Amifampridine; Animals; Arecoline; Carbachol; Colforsin; Dose-Response Relationship, Drug; In Vitro Techniques; Ions; Magnesium; Male; Muscle Contraction; Paralysis; Phorbol 12,13-Dibutyrate; Praziquantel; Schistosoma mansoni; Serotonin | 1993 |
D1 agonists suppress zero Mg(2+)-induced epileptiform activity in the rat cingulate cortex slice.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cerebral Cortex; Colforsin; Dopamine; Dopamine Agents; Epilepsy; Female; Fenoldopam; In Vitro Techniques; Magnesium; Male; Propranolol; Rats; Rats, Wistar; Receptors, Dopamine D1 | 1993 |
Increased transmitter release at excitatory synapses produced by direct activation of adenylate cyclase in rat hippocampal slices.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Electrophysiology; Enzyme Activation; Hippocampus; In Vitro Techniques; Models, Neurological; Neurons; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Synapses | 1994 |
Human proinsulin conversion in the regulated and the constitutive pathways of transfected AtT20 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Chromatography, High Pressure Liquid; Clone Cells; Colforsin; DNA, Complementary; Humans; Insulin; Kinetics; Mice; Pituitary Gland; Pituitary Neoplasms; Proinsulin; Time Factors; Transfection | 1994 |
Expression of hepatocyte growth factor is up-regulated through activation of a cAMP-mediated pathway.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dexamethasone; Dinoprostone; Female; Fibroblasts; Gene Expression; Hepatocyte Growth Factor; Humans; Infant; Kinetics; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Skin; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1994 |
Pharmacological characterization of presynaptic calcitonin gene-related peptide (CGRP) receptors on CGRP-containing vasodilator nerves in rat mesenteric resistance vessels.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcitonin; Calcitonin Gene-Related Peptide; Colforsin; Eels; Feedback; Humans; In Vitro Techniques; Male; Mesenteric Arteries; Neurons; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Vasodilation | 1994 |
Effect of indapamide on cyclic adenosine 3',5'-monophosphate signal transduction system in isolated adult rat cardiomyocytes from normal myocardium and cardiac hypertrophy.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Binding, Competitive; Carbachol; Cardiomegaly; Colforsin; Cyclic AMP; Heart; In Vitro Techniques; Indapamide; Isoproterenol; Male; Myocardium; Rats; Rats, Wistar; Signal Transduction | 1993 |
Effects of glucocorticoid on signalling by prostaglandin E2 in osteoblast-like cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bone Resorption; Cell Line; Colforsin; Cyclic AMP; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; GTP-Binding Proteins; Inositol Phosphates; Mice; Osteoblasts; Phosphatidylinositols; Signal Transduction; Sodium Fluoride | 1993 |
The effect of arachidonic acid on the hydroosmotic action of vasopressin in frog urinary bladder.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arginine Vasopressin; Colforsin; Cyclic AMP; Drug Interactions; Fatty Acids, Nonesterified; In Vitro Techniques; Kinetics; Rana temporaria; Urinary Bladder | 1994 |
Induction of lactase biosynthesis in the human intestinal epithelial cell line Caco-2.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; beta-Galactosidase; Bucladesine; Cell Line; Colforsin; Colonic Neoplasms; Cyclic AMP; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epithelium; Humans; Lactase; Lactase-Phlorizin Hydrolase; Methionine; Microvilli; Sucrase-Isomaltase Complex; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Phorbol ester has different effects on forskolin and beta-adrenergic-stimulated cAMP accumulation in mouse parotid acini.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Cytosol; In Vitro Techniques; Isoproterenol; Male; Membranes; Mice; Parotid Gland; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Cyclic AMP increases the release of parathyroid hormone-related protein from a lung-cancer cell line.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Bucladesine; Calcitonin; Carcinoma, Squamous Cell; Cell Line; Colforsin; Cyclic AMP; Humans; Kinetics; Lung Neoplasms; Neoplasm Proteins; Parathyroid Hormone-Related Protein; Protein Biosynthesis; Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
3-isobutyl-1-methylxanthine inhibits the mutagenic activity of 7,12-dimethylbenz[a]anthracene in epithelial liver cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimutagenic Agents; Biotransformation; Cells, Cultured; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Enzyme Induction; Epithelial Cells; Epithelium; Hypoxanthine Phosphoribosyltransferase; Isoenzymes; Liver; Mutagenesis; Oxygenases | 1994 |
Characterization of magnesium efflux from Ehrlich ascites tumor cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amiloride; Animals; Antimycin A; Bucladesine; Bumetanide; Calcimycin; Carcinoma, Ehrlich Tumor; Colforsin; Cyclic AMP; Energy Metabolism; Glucose; Homeostasis; Imipramine; Kinetics; Magnesium; Mice; Ouabain; Quinidine; Rotenone; Time Factors; Tumor Cells, Cultured | 1994 |
Induction of nitric oxide synthase by cyclic AMP in rat vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Oxidoreductases; Animals; Aorta, Thoracic; Arginine; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Dexamethasone; Enzyme Induction; Kinetics; Muscle, Smooth, Vascular; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Wistar; RNA, Ribosomal | 1994 |
Augmenting effects of cyclic AMP on the heat response of canine testicular polymodal receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Dogs; Hot Temperature; In Vitro Techniques; Male; Nociceptors; Testis | 1993 |
Protein kinase A regulation of cAMP phosphodiesterase expression in rat skeletal myoblasts.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Base Sequence; Bucladesine; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Gene Expression; Molecular Sequence Data; Muscles; Rats; RNA, Messenger | 1994 |
Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Base Sequence; Colforsin; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Peptides; Phosphoserine; Rats; Recombinant Proteins; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship | 1994 |
Antiproliferative effect of prostaglandin E2 in cultured guinea pig tracheal smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Physiological Phenomena; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Guinea Pigs; Male; Muscle, Smooth; Tetradecanoylphorbol Acetate; Trachea | 1994 |
Glutathione protects signal transduction in type II cells under oxidant stress.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Colforsin; Cyclic AMP; Epithelial Cells; Epithelium; Glutathione; Inositol Phosphates; Lung; Male; Peroxides; Phosphatidylcholines; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; tert-Butylhydroperoxide | 1994 |
Functional effects of transgenic expression of cholera toxin in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cholera Toxin; Colforsin; Cyclic AMP; Female; Glucose; GTP-Binding Proteins; Humans; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Molecular Sequence Data; Phenotype; Promoter Regions, Genetic; Recombinant Fusion Proteins; Signal Transduction | 1993 |
Regulation of the 5'-flanking region of the mouse androgen receptor gene by cAMP and androgen.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Androgens; Animals; Base Sequence; Cells, Cultured; Colforsin; Coturnix; Cyclic AMP; Dihydrotestosterone; Fibroblasts; Gene Expression Regulation; Genes; Mice; Molecular Sequence Data; Pituitary Gland, Anterior; Promoter Regions, Genetic; Receptors, Androgen; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Sequence Deletion | 1993 |
Relaxant mechanisms of cyclic AMP-increasing agents in porcine coronary artery.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic beta-Agonists; Animals; Calcium; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; Ethanolamines; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Ryanodine; Swine; Thromboxane A2; Vasodilator Agents | 1994 |
Metabotropic glutamate receptor modulation of cAMP accumulation in the neonatal rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Deaminase; Animals; Animals, Newborn; Colforsin; Cyclic AMP; Cycloleucine; Female; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Neurotoxins; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzimidazoles; Chloride Channels; Chlorophenols; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Ion Channel Gating; Kinetics; Membrane Potentials; Membrane Proteins; Oocytes; Plasmids; Transfection; Vero Cells; Xenopus laevis | 1994 |
Regulation of immunoreactive insulin-like growth factor binding protein-6 in normal and transformed human fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carrier Proteins; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cholera Toxin; Colforsin; Culture Media, Conditioned; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Humans; Insulin-Like Growth Factor Binding Protein 6; Insulin-Like Growth Factor II; Kinetics; Male; Molecular Weight; Recombinant Proteins; Simian virus 40; Skin; Transforming Growth Factor beta; Tretinoin; Virulence Factors, Bordetella | 1994 |
Regulation of tetrahydrobiopterin biosynthesis in cultured dopamine neurons by depolarization and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biopterins; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Dopamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; GTP Cyclohydrolase; Hypothalamus; Kinetics; Membrane Potentials; Mesencephalon; Neurons; Pregnancy; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Transcription, Genetic; Veratridine | 1994 |
Effects of signalling transduction modulators on the transformed phenotypes in v-H-ras-transformed NIH 3T3 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Catechols; Colforsin; Genes, ras; Genistein; Isoflavones; Mice; Nitriles; Phenotype; Signal Transduction; Tyrphostins | 1993 |
Chloride currents in freshly isolated rat retinal pigment epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; In Vitro Techniques; Ion Channels; Ionomycin; Membrane Potentials; Osmolar Concentration; Pigment Epithelium of Eye; Rats; Rats, Inbred Strains; Thionucleotides | 1994 |
The role of the inwardly rectifying K+ current in resting potential and thyrotropin-releasing-hormone-induced changes in cell excitability of GH3 rat anterior pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Culture Media; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Membrane Potentials; Pituitary Gland, Anterior; Potassium Channels; Protein Kinases; Rats; Thyrotropin-Releasing Hormone | 1994 |
Forskolin and 3-isobutyl-1-methylxanthine increase basal and sodium nitroprusside-elevated cyclic GMP levels in adult guinea-pig cerebellar slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cerebellum; Colforsin; Cyclic AMP; Cyclic GMP; Ferrocyanides; Guinea Pigs; In Vitro Techniques; Nitric Oxide; Nitroprusside | 1994 |
Cross talk among cyclic AMP, cyclic GMP, and Ca(2+)-dependent intracellular signalling mechanisms in brain capillary endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Capillaries; Cells, Cultured; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cyclic GMP; Endothelins; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Intracellular Membranes; Isoproterenol; Rats; Receptors, Endothelin; Signal Transduction | 1994 |
Amylin (islet amyloid polypeptide) inhibition of insulin release in the perfused rat pancreas: implication of the adenylate cyclase/cAMP system.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Amyloid; Animals; Colforsin; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Insulin Secretion; Islet Amyloid Polypeptide; Islets of Langerhans; Male; Perfusion; Rats; Rats, Wistar | 1994 |
Pituitary adenylate cyclase-activating polypeptide effects in pituitary cells: modulation by gonadotropin-releasing hormone in alpha T3-1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Calcimycin; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Enzyme Activation; Gonadotropin-Releasing Hormone; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1994 |
Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Basophils; Calcium; Colforsin; Cyclic AMP; Cytosol; Fluorescent Dyes; Fura-2; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Kinetics; Leukotrienes; Microscopy, Fluorescence; N-Formylmethionine Leucyl-Phenylalanine; Pyrrolidinones; Rolipram; Time Factors | 1994 |
Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Antihypertensive Agents; Carbachol; Colforsin; Cytosol; Dinoprost; Dose-Response Relationship, Drug; Female; Humans; Isoenzymes; Kinetics; Lung Neoplasms; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Purinones; Pyridazines; Pyrrolidinones; Rolipram | 1994 |
Melatonin receptor-mediated inhibition of cyclic AMP accumulation in chick retinal cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; 5-Methoxytryptamine; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Iodine Radioisotopes; Melatonin; Neurons; Pertussis Toxin; Photoreceptor Cells; Potassium; Receptors, Cell Surface; Receptors, Melatonin; Retina; Second Messenger Systems; Structure-Activity Relationship; Tryptamines; Virulence Factors, Bordetella | 1994 |
Alpha 2-adrenoceptor-mediated inhibition of electrically evoked [3H]noradrenaline release from chick sympathetic neurons: role of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-Agonists; Adrenergic Fibers; Animals; Brimonidine Tartrate; Calcium Channels; Cells, Cultured; Chick Embryo; Cholera Toxin; Colforsin; Cyclic AMP; Electric Stimulation; Neurons; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha-2; Tritium | 1994 |
S35b, a new phenylsulfonylfuroxan compound, inhibits thrombin-induced synthesis of platelet-activating factor and prostacyclin in human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetyltransferases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Humans; Iloprost; Oxadiazoles; Platelet Activating Factor; Platelet Aggregation Inhibitors; Thrombin; Umbilical Veins | 1993 |
Effect of interventions that increase cyclic AMP levels on susceptibility to ventricular fibrillation in unanesthetized dogs.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Anesthesia; Animals; Colforsin; Cyclic AMP; Death, Sudden, Cardiac; Dogs; Enzyme Activation; Isoproterenol; Myocardial Infarction; Myocardium; Ventricular Fibrillation | 1994 |
Histotypic in vitro reorganization of dissociated cells from mouse fetal gonads.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Basement Membrane; Biocompatible Materials; Bucladesine; Cell Aggregation; Cell Movement; Cells, Cultured; Colforsin; Collagen; Cyclic AMP; Cycloheximide; Cytochalasin B; Drug Combinations; Gestational Age; Laminin; Male; Mice; Microscopy, Electron, Scanning; Morphogenesis; Proteoglycans; Testis; Tunicamycin | 1994 |
Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion.
Topics: 1-Methyl-3-isobutylxanthine; Algorithms; Amino Acid Sequence; Animals; Base Sequence; Bucladesine; Cell Membrane; Chloride Channels; CHO Cells; Colforsin; Consensus Sequence; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; Glycosylation; Humans; Lipid Bilayers; Mammals; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Recombinant Proteins; Transfection | 1994 |
Limited modulation of the mitogen-activated protein kinase pathway by cyclic AMP in rat parotid acinar cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Isoproterenol; Kinetics; Myelin Basic Protein; Parotid Gland; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats | 1994 |
Protein kinase C and protein kinase A regulate the expression of angiotensin II receptor mRNA in smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Angiotensin II; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Fura-2; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Polymerase Chain Reaction; Protein Kinase C; Rats; Rats, Wistar; Receptors, Angiotensin; RNA, Messenger | 1994 |
Caffeine inhibits cytosolic calcium oscillations induced by noradrenaline and vasopressin in rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Caffeine; Calcium; Colforsin; Cytosol; Dose-Response Relationship, Drug; Female; Inositol 1,4,5-Trisphosphate; Liver; Norepinephrine; Rats; Rats, Wistar; Vasopressins | 1994 |
PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; Baculoviridae; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Peptide Mapping; Phorbol Esters; Phosphopeptides; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 12; Protein Tyrosine Phosphatases; Recombinant Proteins; Sequence Analysis; Serine; Tetradecanoylphorbol Acetate | 1994 |
Vasoactive intestinal peptide (VIP) inhibits substrate adherence capacity of rat peritoneal macrophages by a mechanism that involves cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Adhesion; Colforsin; Cyclic AMP; In Vitro Techniques; Macrophages, Peritoneal; Male; Rats; Rats, Wistar; Somatostatin; Time Factors; Vasoactive Intestinal Peptide | 1993 |
Glucocorticoids potentiate the adenylyl cyclase-cAMP system mediated immunoreactive beta-endorphin production and secretion from hypothalamic neurons in culture.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Animals, Newborn; beta-Endorphin; Blotting, Northern; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Glucocorticoids; Hypothalamus; Neurons; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1994 |
Involvement of cAMP and cGMP in the mode of action of molt-inhibiting hormone (MIH) a neuropeptide which inhibits steroidogenesis in a crab.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brachyura; Bucladesine; Colforsin; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Ecdysone; Invertebrate Hormones | 1994 |
A novel Gs alpha mutant in a patient with Albright hereditary osteodystrophy uncouples cell surface receptors from adenylyl cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aluminum; Base Sequence; Child, Preschool; Codon; Colforsin; Cyclic AMP; Erythrocyte Membrane; Exons; Fluorine; Genes, Dominant; GTP-Binding Proteins; Heterozygote; Humans; Isoproterenol; Male; Molecular Sequence Data; Mutation; Phenotype; Pseudohypoparathyroidism; Receptors, Cell Surface; Recombinant Proteins; Signal Transduction | 1994 |
A large contribution of a cyclic AMP-independent pathway to turtle olfactory transduction.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Epithelial Cells; Epithelium; Nitriles; Olfactory Pathways; Olfactory Receptor Neurons; Signal Transduction; Thionucleotides; Turtles | 1994 |
Stimulatory effect of histamine on cyclic AMP formation in chick pineal gland.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Analysis of Variance; Animals; Carbon Radioisotopes; Chickens; Colforsin; Cyclic AMP; Dimaprit; Guinea Pigs; Hippocampus; Histamine; Histamine Agonists; In Vitro Techniques; Kinetics; Male; Methylhistamines; Pineal Gland; Ranitidine; Rats; Rats, Wistar; Thiazoles; Tritium | 1994 |
Rate-limiting steps in activation of cardiac Cl- current revealed by photolytic application of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Ethers, Cyclic; Guinea Pigs; Heart; Heart Ventricles; Isoproterenol; Kinetics; Membrane Potentials; Okadaic Acid; Photolysis; Temperature; Time Factors; Ultraviolet Rays; Vasoconstrictor Agents | 1994 |
Potentiation by forskolin of both SNP- and ANP-stimulated cyclic GMP accumulation in porcine isolated palmar lateral vein.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Colforsin; Cyclic GMP; Drug Synergism; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroprusside; Pyrrolidinones; Rolipram; Veins | 1994 |
Angiotensin II induced alteration of cyclic adenosine 3',5'-monophosphate generation in the hypertrophic myocardium of Dahl salt-sensitive rat on a high-salt diet.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Angiotensin II; Animals; Cardiomegaly; Cell Size; Colforsin; Cyclic AMP; Diet; Flow Cytometry; In Vitro Techniques; Isoproterenol; Male; Muscle Proteins; Pertussis Toxin; Rats; Rats, Inbred Strains; Sodium Chloride; Virulence Factors, Bordetella | 1994 |
Transcriptional regulation of plasminogen activator inhibitor-1 expression in human synovial fibroblasts by prostaglandin E2: mediation by protein kinase A and role of interleukin-1.
Topics: 1-Methyl-3-isobutylxanthine; Blood; Cadaver; Cells, Cultured; Colforsin; Culture Media; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Fibroblasts; Gene Expression Regulation; Humans; Interleukin-1; Plasminogen Activator Inhibitor 1; Protein Kinase Inhibitors; RNA, Messenger; Synovial Membrane; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Ornithine decarboxylase gene expression is aberrantly regulated via the cAMP signal transduction pathway in malignant H-ras transformed cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Transformation, Neoplastic; Colforsin; Cyclic AMP; Fibroblasts; Gene Expression; Gene Expression Regulation; Genes, ras; Mice; Ornithine Decarboxylase; Protein Biosynthesis; Protein Kinases; Signal Transduction; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1994 |
Endothelin secretion is regulated by cyclic AMP and phosphatase 2A in endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Endothelins; Endothelium, Vascular; Ethers, Cyclic; Humans; In Vitro Techniques; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 2 | 1994 |
Neuropeptide Y inhibits adenylyl cyclase activity in rabbit retina.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Inositol Phosphates; Neuropeptide Y; Rabbits; Receptors, Neuropeptide Y; Retina | 1994 |
Phorbol ester activation of protein kinase C inhibits CNP-stimulated cyclic GMP production in the mouse AtT-20 pituitary tumour cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cell Line; Colforsin; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Mice; Natriuretic Peptide, C-Type; Pituitary Neoplasms; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Effect of sympathetic denervation on the relaxing responses of rabbit arterial smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Colforsin; Cyclic AMP; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroprusside; Purinones; Rabbits; Sympathectomy, Chemical; Vasodilation | 1994 |
Attenuation of adenylate cyclase-induced increases in renal sodium excretion by the dopamine D-2 receptor agonist SK&F 89124.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Domperidone; Hemodynamics; Indoles; Kidney; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Sodium | 1994 |
YC-1, a novel activator of platelet guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alprostadil; Animals; Bleeding Time; Blood Platelets; Calcium; Colforsin; Collagen; Cyclic AMP; Cyclic GMP; Drug Interactions; Enzyme Activation; Guanylate Cyclase; Imidazoles; Indazoles; Indomethacin; Methemoglobin; Mice; Molecular Structure; Nitroprusside; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Prostaglandin D2; Rabbits; Superoxide Dismutase; Thromboxane A2 | 1994 |
Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA-preferring glutamate receptors.
Topics: 1-Methyl-3-isobutylxanthine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Phosphorylation; Rats; Receptors, Glutamate; Synapses | 1994 |
Cytochrome P4502A5 expression and inducibility by phenobarbital is modulated by cAMP in mouse primary hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aryl Hydrocarbon Hydroxylases; Bucladesine; Cells, Cultured; Colforsin; Cycloheximide; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dactinomycin; Enzyme Induction; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Phenobarbital; RNA, Messenger | 1994 |
Forskolin and methylxanthines block the increase in intracellular pH during meiosis in Xenopus laevis oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbon Radioisotopes; Colforsin; Cyclic AMP; Female; Hydrogen-Ion Concentration; Meiosis; Oocytes; Progesterone; Sodium-Hydrogen Exchangers; Theophylline; Xenopus laevis | 1994 |
Granulocyte-macrophage colony-stimulating factor expression by human fibroblasts is both upregulated and subsequently downregulated by interleukin-1.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dinoprostone; Fibroblasts; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Interleukin-1; Lung; RNA, Messenger | 1995 |
Transcription of the brain creatine kinase gene in glial cells is modulated by cyclic AMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brain; Brain Neoplasms; Cloning, Molecular; Colforsin; Creatine Kinase; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Energy Metabolism; Enzyme Activation; Enzyme Induction; Glioblastoma; Glioma; HeLa Cells; Humans; Isoenzymes; Isoquinolines; Myelin Sheath; Nerve Tissue Proteins; Neuroglia; Protein Synthesis Inhibitors; Rats; Recombinant Fusion Proteins; RNA, Antisense; Sulfonamides; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1994 |
cAMP-enhancing agents "permit" stimulus-secretion coupling in canine pancreatic islet beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Membrane; Colforsin; Cyclic AMP; Dogs; Exocytosis; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Membrane Potentials; Thionucleotides; Tolbutamide | 1994 |
Cyclic 3',5'-adenosine monophosphate mediates dopamine D1-stimulated growth hormone release from goldfish pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine Agonists; Ergolines; Goldfish; Growth Hormone; In Vitro Techniques; Indicators and Reagents; Isoquinolines; Pituitary Gland; Quinpirole; Receptors, Dopamine D1; Sulfonamides | 1994 |
Changes in alpha 1-adrenergic neurotransmission alter the number of somatostatin receptors in the rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Colforsin; Cyclic AMP; Down-Regulation; Enzyme Activation; Hippocampus; Learning; Phenylephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Somatostatin; Signal Transduction; Somatostatin | 1994 |
cAMP is not involved in interleukin-1-induced interleukin-6 release from human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Astrocytoma; Bucladesine; Colforsin; Cyclic AMP; Humans; Interleukin-1; Interleukin-6; Isoproterenol; Tumor Cells, Cultured | 1994 |
Modulatory mechanisms of cyclic AMP-stimulated steroid content in rat brain cortex.
Topics: 1-Methyl-3-isobutylxanthine; Adrenalectomy; Animals; Benzodiazepinones; Bucladesine; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; In Vitro Techniques; Isoquinolines; Male; Orchiectomy; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 1994 |
Is cyclic AMP involved in excitatory amino acid-evoked adenosine release from rat cortical slices?
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Calcium; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Excitatory Amino Acids; Male; N-Methylaspartate; Parietal Lobe; Probenecid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Impaired cyclic nucleotide-dependent vasorelaxation in human umbilical artery smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carotid Arteries; Cattle; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; In Vitro Techniques; Isometric Contraction; Kinetics; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Phosphorylation; Serotonin; Umbilical Arteries | 1995 |
Cell line-dependent changes in sensitivity to mitomycin C by 1-methyl-3-isobutylxanthine is due to an altered intracellular dose of the anticancer drug and/or to changes in DT-diaphorase activity.
Topics: 1-Methyl-3-isobutylxanthine; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Mitomycin; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Tumor Cells, Cultured | 1994 |
Voltage-activated K channel in luminal membrane of marginal cells of stria vascularis dissected from guinea pig.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cyclic GMP; Cytoplasm; Electric Stimulation; Electrophysiology; Gluconates; Guinea Pigs; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Sodium Chloride; Stria Vascularis | 1994 |
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Kinetics; Membrane Potentials; Neostriatum; Neurons; Nifedipine; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Rats, Wistar; Receptors, Dopamine D1; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors | 1995 |
Characterization of C6-10A glioma cells highly responsive to beta-adrenergic receptor agonist-induced NGF synthesis/secretion.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood; Bucladesine; Cattle; Cell Division; Cell Line; Cholera Toxin; Colforsin; Culture Media; Dose-Response Relationship, Drug; Epinephrine; Fibronectins; Glial Fibrillary Acidic Protein; Glioma; Immunoenzyme Techniques; Immunohistochemistry; Kinetics; Myelin Basic Protein; Nerve Growth Factors; Neurotransmitter Agents; Rats; S100 Proteins; Time Factors; Tumor Cells, Cultured | 1994 |
Ammonium acetate inhibits ionotropic receptors and differentially affects metabotropic receptors for glutamate.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Neurotoxins; Phosphatidylinositols; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Oxidoreductases; Animals; Arginine; Colforsin; Cyclic AMP; Cyclic GMP; Female; Glucose; Hydrogen Peroxide; Hydroxylamine; Hydroxylamines; In Vitro Techniques; Insulin; Islets of Langerhans; Mice; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxides; Reactive Oxygen Species; tert-Butylhydroperoxide; Vasodilator Agents | 1995 |
Isoproterenol exerts cyclic AMP independent effects on DNA synthesis in cultured adventitial fibroblasts from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta; Cells, Cultured; Colforsin; Cyclic AMP; DNA Replication; Epidermal Growth Factor; Fibroblasts; Isoproterenol; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1994 |
Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Ribonucleases; RNA, Messenger | 1995 |
Rectification of whole cell cystic fibrosis transmembrane conductance regulator chloride current.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Anions; Cell Line; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Epithelium; Guinea Pigs; Heart; Membrane Proteins; Phosphorylation; Transfection | 1995 |
Vasoactive intestinal polypeptide stimulates cyclic AMP production in mouse N1E-115 neuroblastoma cells: modulation by a protein kinase C activator and ionomycin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carcinogens; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Enzyme Activation; Ionomycin; Isoquinolines; Kinetics; Mice; Neuroblastoma; Phorbol Esters; Piperazines; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1994 |
Role of F-actin in the activation of Na(+)-K(+)-Cl- cotransport by forskolin and vasopressin in mouse kidney cultured thick ascending limb cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Animals; Arginine Vasopressin; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Cytoskeleton; Dinoprostone; Diuretics; Ion Transport; Isoproterenol; Loop of Henle; Male; Mice; Nocodazole; Ouabain; Parathyroid Hormone; Phalloidine; Potassium; Sodium | 1994 |
Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Polyomavirus Transforming; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Intestinal Neoplasms; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Electron; Neoplasm Transplantation; Peptide Fragments; Proglucagon; Protein Precursors; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
cAMP-dependent inward rectifier current in neurons of the rat suprachiasmatic nucleus.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Membrane; Colforsin; Cyclic AMP; Extracellular Space; Ion Channels; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Inbred WKY; Suprachiasmatic Nucleus | 1994 |
Colorimetric assay for rapid screening of corticotropin releasing factor receptor ligands.
Topics: 1-Methyl-3-isobutylxanthine; Animals; beta-Galactosidase; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Ligands; Mass Screening; Rats; Receptors, Corticotropin-Releasing Hormone | 1994 |
Interleukin-1 beta induces cyclic AMP formation in isolated human osteoblasts: a signalling mechanism that is not related to enhanced prostaglandin formation.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Bone Resorption; Calcimycin; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Dose-Response Relationship, Drug; Humans; Ilium; Indomethacin; Interleukin-1; Osteoblasts; Recombinant Proteins | 1994 |
Change in vascular cAMP and cGMP contents in portal hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Colforsin; Cyclic AMP; Cyclic GMP; Hemodynamics; Hypertension, Portal; Rats; Rats, Sprague-Dawley | 1995 |
Discrete endogenous signals mediate neural competence and induction in P19 embryonal carcinoma stem cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Colforsin; Dimethyl Sulfoxide; DNA-Binding Proteins; Embryonal Carcinoma Stem Cells; Embryonic Induction; Fetal Proteins; Fluorescent Antibody Technique; Gene Expression; Gene Expression Regulation; Histocytochemistry; Neoplastic Stem Cells; Nerve Tissue; Paired Box Transcription Factors; PAX3 Transcription Factor; Protein Kinase C; Signal Transduction; T-Box Domain Proteins; Transcription Factors | 1994 |
Rat testicular myoid cells express vasopressin receptors: receptor structure, signal transduction, and developmental regulation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aging; Amino Acid Sequence; Animals; Arginine Vasopressin; Base Sequence; Blotting, Northern; Cells, Cultured; Cloning, Molecular; Colforsin; Consensus Sequence; Cyclic AMP; DNA Primers; Gene Expression Regulation; Inositol Phosphates; Male; Molecular Sequence Data; Muscle, Smooth; Phosphoric Diester Hydrolases; Rats; Rats, Wistar; Receptors, Vasopressin; Seminiferous Tubules; Sequence Homology, Amino Acid; Sexual Maturation; Signal Transduction; Testis | 1995 |
cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Calcium; Chloride Channels; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Genistein; Intracellular Membranes; Isoflavones; Membrane Proteins; Mice; Protein-Tyrosine Kinases; Vanadates | 1995 |
Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Electric Stimulation; Gastric Fundus; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Rats; Rats, Wistar; Signal Transduction; Vasoactive Intestinal Peptide | 1995 |
cAMP-mediated signals as determinants for apoptosis in primary granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Apoptosis; Cells, Cultured; Chorionic Gonadotropin; Colforsin; Culture Media, Serum-Free; Cyclic AMP; DNA; Female; Fibroblast Growth Factor 2; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Granulosa Cells; Kinetics; Microscopy, Electron; Microvilli; Mitochondria; Progesterone; Rats; Signal Transduction; Time Factors | 1995 |
Inhibition of 3T3-L1 adipose differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Animals; Avian Sarcoma Viruses; Azo Compounds; Cell Differentiation; Colforsin; Coloring Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Gene Expression; Glycerolphosphate Dehydrogenase; Kinetics; Mammary Tumor Virus, Mouse; Mice; Polychlorinated Dibenzodioxins; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transfection | 1995 |
Calcium efflux from cultured bovine adrenal chromaffin cells induced by pituitary adenylate cyclase-activating polypeptide (PACAP): possible involvement of an Na+/Ca2+ exchange mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Medulla; Amiloride; Animals; Calcium; Carrier Proteins; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Inositol Phosphates; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Sodium-Calcium Exchanger; Tetradecanoylphorbol Acetate | 1995 |
Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Benzoxazines; Cannabinoids; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Activation; Hippocampus; In Vitro Techniques; Ion Channel Gating; Morpholines; Naphthalenes; Neurons; Potassium Channels; Rats; Receptors, Cannabinoid; Receptors, Drug | 1995 |
Autonomic regulation of cardiac chloride current.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Autonomic Agents; Chloride Channels; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Isoproterenol | 1994 |
Developmental changes in modulation of contractility of rabbit hearts.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Blood Pressure; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Heart Ventricles; Isoproterenol; Myocardial Contraction; Phosphodiesterase Inhibitors; Rabbits; Receptors, Adrenergic, beta; Signal Transduction; Ventricular Function, Left | 1995 |
Histamine and the cAMP pathway in the guinea-pig pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Amylases; Animals; Colforsin; Cyclic AMP; Guinea Pigs; Histamine; Pancreas; Vasoactive Intestinal Peptide | 1995 |
Caffeine inhibits the binding of thyrotropin-releasing hormone in GH4C1 pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Cell Line; Colforsin; Ionomycin; Kinetics; Nimodipine; Pituitary Gland; Protein Binding; Rats; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone | 1995 |
Zatebradine attenuates cyclic AMP-related positive chronotropic but not inotropic responses in isolated, perfused right atria of the dog.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic Agonists; Animals; Benzazepines; Cardiovascular Agents; Colforsin; Dogs; Heart Atria; Heart Rate; Myocardial Contraction; Stimulation, Chemical | 1995 |
ATPo but not cAMPi activates a chloride conductance in mouse ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Chloride Channels; Colforsin; Cyclic AMP; Cystic Fibrosis; Isoproterenol; Membrane Potentials; Mice; Mice, Knockout; Myocardium; Patch-Clamp Techniques; Stimulation, Chemical | 1995 |
Hormonal regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 in cultured monkey Sertoli cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hormones; Macaca mulatta; Male; Plasminogen Activator Inhibitor 1; RNA Probes; RNA, Messenger; Sertoli Cells; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1995 |
Forskolin enhanced off-response in the turtle olfactory system.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Ion Channel Gating; Neurons, Afferent; Odorants; Olfactory Mucosa; Smell; Turtles | 1994 |
The second messenger, cyclic AMP, is not sufficient for myelin gene induction in the peripheral nervous system.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Denervation; Drug Combinations; Gene Expression Regulation; Male; Myelin P0 Protein; Myelin Proteins; Myelin Sheath; Nerve Crush; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Second Messenger Systems; Transcriptional Activation | 1995 |
Factors regulating the production of vasopressin-associated human neurophysin by small-cell carcinoma of the lung: evaluation by computer-enhanced quantitative immunocytochemistry.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Carcinoma, Small Cell; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Densitometry; Dexamethasone; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Lung Neoplasms; Neoplasm Proteins; Neurophysins; Tumor Cells, Cultured; Vasopressins | 1995 |
Cyclic adenosine monophosphate-dependent mechanisms induce von Willebrand factor expression in the Dami megakaryoblastic cell line.
Topics: 1-Methyl-3-isobutylxanthine; Aneuploidy; Bucladesine; Colforsin; Cyclic AMP; Fluorescent Antibody Technique; Gene Expression Regulation, Leukemic; Humans; L-Lactate Dehydrogenase; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Neoplasm Proteins; Pentoxifylline; Platelet Membrane Glycoproteins; Tumor Cells, Cultured; von Willebrand Factor | 1995 |
A cyclic-nucleotide-suppressible conductance activated by transducin in taste cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Humans; Membrane Potentials; Nucleotides, Cyclic; Peptide Fragments; Phosphoric Diester Hydrolases; Rana catesbeiana; Taste; Taste Buds; Transducin | 1995 |
Brefeldin A provokes indirect activation of cdc2 kinase (MPF) in Xenopus oocytes, resulting in meiotic cell division.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brefeldin A; CDC2 Protein Kinase; Cell Cycle; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Cyclopentanes; Enzyme Activation; Maturation-Promoting Factor; Meiosis; Oocytes; Oogenesis; Peptide Elongation Factor 1; Peptide Elongation Factors; Phosphorylation; Progesterone; Protamine Kinase; Protein Processing, Post-Translational; Signal Transduction; Xenopus laevis | 1995 |
Isolation of small polarized bile duct units.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicarbonates; Bile Ducts; Bucladesine; Chlorides; Cholestasis; Colforsin; Fluoresceins; Gluconates; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Microscopy, Electron; Microscopy, Video; Rats; Rats, Sprague-Dawley; Secretin; Time Factors | 1995 |
VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Carbazoles; Cell Cycle; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Dose-Response Relationship, Drug; Glucagon; Histamine; Histamine Antagonists; Humans; Indoles; Kinetics; Muscle, Smooth; Pyrroles; Thymidine; Trachea; Vasoactive Intestinal Peptide | 1995 |
Regulation of the adenylyl cyclase signaling system in various types of cultured endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Bucladesine; Cattle; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP-Binding Proteins; Histamine; Humans; Isoproterenol; Phosphoric Diester Hydrolases; Signal Transduction; Swine; Virulence Factors, Bordetella | 1995 |
IBMX induces calcium release from intracellular stores in rat sensory neurones.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Biological Transport; Bucladesine; Caffeine; Calcium; Cell Compartmentation; Colforsin; Cyclic GMP; Dibutyryl Cyclic GMP; Endoplasmic Reticulum; Ganglia, Spinal; Neurons, Afferent; Rats; Theophylline | 1995 |
Bursal antisteroidogenic peptide alters the activity of steroidogenic enzymes in chicken granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; 3-Hydroxysteroid Dehydrogenases; Adenylyl Cyclases; Animals; Bursa of Fabricius; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Female; Granulosa Cells; Hydroxycholesterols; Luteinizing Hormone; Peptides; Phosphoric Diester Hydrolases; Pregnenolone; Progesterone; Radioimmunoassay | 1995 |
Phosphorylation regulates the water channel activity of the seed-specific aquaporin alpha-TIP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Base Sequence; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Female; Genes, Plant; Membrane Proteins; Molecular Sequence Data; Mutation; Oocytes; Osmosis; Phosphorylation; Plant Proteins; Protein Conformation; Seeds; Serine; Xenopus | 1995 |
The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Granulosa Cells; Humans; Mice; Molecular Sequence Data; Nuclear Proteins; Point Mutation; Promoter Regions, Genetic; Rats; Sequence Alignment; Species Specificity; Tissue Plasminogen Activator; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1995 |
Activity-induced facilitation of L-type Ca2+ current in cardiomyocytes isolated from guinea-pig ventricles.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Barium; Calcium; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Egtazic Acid; Guinea Pigs; Heart Ventricles; Isoproterenol; Male; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Phosphoric Diester Hydrolases; Sodium; Temperature | 1995 |
A novel neuropeptide cellular mechanism in amphibian interrenal steroidogenesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aromatase; Aspirin; Bucladesine; Colforsin; Dinoprost; Dinoprostone; Estradiol; Female; Gonadotropin-Releasing Hormone; Hydroxyprostaglandin Dehydrogenases; In Vitro Techniques; Interrenal Gland; Models, Biological; Palmitic Acid; Palmitic Acids; Rana esculenta; Testosterone | 1995 |
Cyclic AMP modulates adipogenesis in 3T3-F442A cells.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Cell Differentiation; Cholera Toxin; Colforsin; Cyclic AMP; Fibroblasts; Glycerolphosphate Dehydrogenase; Insulin; Kinetics; Mice; Thionucleotides | 1995 |
Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of pp42 mitogen-activated protein kinase by protein kinase C and protein kinase A in EAhy926 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Indoles; Isoenzymes; Lysophospholipids; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Inhibition of serine/threonine protein phosphatases enhances agonist-stimulated cAMP accumulation in UMR 106 osteoblast-like cells.
Topics: 1-Methyl-3-isobutylxanthine; Antifungal Agents; Colforsin; Cyclic AMP; Dinoprostone; Ethers, Cyclic; Humans; Kinetics; Marine Toxins; Okadaic Acid; Osteoblasts; Oxazoles; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Protein Serine-Threonine Kinases; Proteins; Pyrans; Spiro Compounds; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Regulation of bradykinin-stimulated phospholipase C and arachidonic acid release by protein kinase A in MDCK-D1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arginine Vasopressin; Bradykinin; Calcimycin; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Dogs; Enzyme Activation; Enzyme Inhibitors; Estrenes; Inositol Phosphates; Ionophores; Isoquinolines; Kidney; Pyrrolidinones; Sulfonamides; Type C Phospholipases | 1995 |
Cyclic AMP stimulates a JunD/Fra-2 AP-1 complex and inhibits the proliferation of interleukin-6-dependent cell lines.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Base Sequence; Cell Division; Cell Line; Colforsin; Cyclic AMP; DNA; DNA-Binding Proteins; Fos-Related Antigen-2; Humans; Interleukin-6; Mice; Molecular Sequence Data; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Transcription Factor AP-1; Transcription Factors; Transcriptional Activation | 1995 |
8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Adenosine Deaminase; Amino Acid Sequence; Apoptosis; Biotransformation; Breast Neoplasms; Chromatin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Damage; Ethers, Cyclic; Female; Humans; Marine Toxins; Microvilli; Molecular Sequence Data; Necrosis; Okadaic Acid; Organelles; Oxazoles; Phosphoprotein Phosphatases | 1995 |
Cell cycle-dependent morphological changes in the actin cytoskeleton induced by agents which elevate cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Actins; Animals; Bucladesine; Cell Cycle; Colforsin; Cyclic AMP; Cytoskeleton; Mice; Phosphodiesterase Inhibitors | 1995 |
Potentiation of P1075-induced K+ channel opening by stimulation of adenylate cyclase in rat isolated aorta.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta; Binding, Competitive; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Isoquinolines; Isotope Labeling; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Potassium Channels; Pyridines; Rats; Rats, Sprague-Dawley; Rubidium; Sulfonamides; Vasodilator Agents | 1995 |
Effects of timolol, terbutaline and forskolin on IOP, aqueous humour formation and ciliary cyclic AMP levels in the bovine eye.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Aqueous Humor; Cattle; Cells, Cultured; Ciliary Body; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Epithelium; Intraocular Pressure; Perfusion; Phosphodiesterase Inhibitors; Terbutaline; Timolol | 1995 |
Hormone stimulation of type III adenylyl cyclase induces Ca2+ oscillations in HEK-293 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Humans; Inositol 1,4,5-Trisphosphate Receptors; Isoproterenol; Isoquinolines; Kidney; Kinetics; Models, Biological; Oscillometry; Phosphatidylinositols; Piperazines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucagon; Signal Transduction; Time Factors | 1995 |
Cell-to-cell contact via measles virus haemagglutinin-CD46 interaction triggers CD46 downregulation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies, Viral; Antigens, CD; Bucladesine; Cell Communication; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Hemagglutinins, Viral; Humans; Measles virus; Membrane Cofactor Protein; Membrane Glycoproteins; Mice; Phosphodiesterase Inhibitors; Protein Kinase C; Receptors, Virus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Intracellular mechanisms of cytoplasmic Ca2+ oscillation in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alkaloids; Animals; Calcimycin; Calcium; Calcium-Transporting ATPases; Calmodulin; Colforsin; Cyclic AMP; Cytoplasm; Egtazic Acid; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Megakaryocytes; Models, Biological; Oscillometry; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Trifluoperazine | 1993 |
Prolonged exposure to melatonin leads to time-dependent sensitization of adenylate cyclase and down-regulates melatonin receptors in pars tuberalis cells from ovine pituitary.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Aluminum; Aluminum Compounds; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Down-Regulation; Fluorides; Iodine Radioisotopes; Kinetics; Melatonin; Pituitary Gland, Anterior; Receptors, Melatonin; Receptors, Neurotransmitter; Sheep | 1993 |
Prostaglandins stimulate serotonin acetylation in chick pineal cells: involvement of cyclic AMP-dependent and calcium/calmodulin-dependent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylation; Alprostadil; Animals; Arylamine N-Acetyltransferase; Calcium; Calmodulin; Cells, Cultured; Chickens; Cloprostenol; Colforsin; Cyclic AMP; Dinoprost; Dinoprostone; Indomethacin; Kinetics; Pineal Gland; Prostaglandins; Serotonin; Sulfonamides | 1993 |
Regulation of cyclic AMP levels by phorbol esters in bovine adrenal medullary cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adrenal Medulla; Animals; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Indoles; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Virulence Factors, Bordetella | 1993 |
Basal transcriptional activity and cyclic adenosine 3',5'-monophosphate responsiveness of the human cytochrome P450scc promoter transfected into MA-10 Leydig cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cell Line; Cholesterol Side-Chain Cleavage Enzyme; Colforsin; Cyclic AMP; Dactinomycin; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Leydig Cells; Luciferases; Male; Mice; Mitochondria; Promoter Regions, Genetic; Recombinant Fusion Proteins; Transcription, Genetic; Transfection | 1993 |
Protein kinase C regulation of prolactin gene expression in lactotroph cells: involvement in dopamine inhibition.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bromocriptine; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Kinetics; Nifedipine; Pituitary Gland, Anterior; Potassium; Prolactin; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Cyclic AMP distinguishes between two functions of acidic FGF in a rat bladder carcinoma cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzylidene Compounds; Cell Division; Cholera Toxin; Colforsin; Cyclic AMP; DNA Replication; Fibroblast Growth Factor 1; Genistein; Isoflavones; Kinetics; Nitriles; Protein-Tyrosine Kinases; Rats; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured; Tyrphostins; Urinary Bladder Neoplasms; Vanadates; Virulence Factors, Bordetella | 1993 |
Endotoxin-induced tissue factor messenger RNA in human monocytes is negatively regulated by a cyclic AMP-dependent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Blotting, Northern; Bucladesine; Colforsin; Cyclic AMP; Dactinomycin; Escherichia coli; Flow Cytometry; Humans; Lipopolysaccharides; Monocytes; RNA, Messenger; Thromboplastin; Transcription, Genetic | 1993 |
Effect of bradykinin and prostaglandins on the release of calcitonin gene-related peptide-like immunoreactivity from the rat spinal cord in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Colforsin; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Male; Molecular Sequence Data; Prostaglandins; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
Hydrogen peroxide evokes antisteroidogenic and antigonadotropic actions in human granulosa luteal cells.
Topics: 1-Methyl-3-isobutylxanthine; Aluminum; Aluminum Compounds; Cells, Cultured; Cholera Toxin; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Estradiol; Female; Fluorides; Granulosa Cells; Humans; Hydrogen Peroxide; Luteal Cells; Progesterone; Steroids | 1993 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Monoclonal; Antibody Specificity; Cells, Cultured; Colforsin; Diacylglycerol Kinase; Epidermal Growth Factor; Epitopes; ErbB Receptors; Escherichia coli; Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1993 |
Interleukin-1 beta effects on cyclic GMP and cyclic AMP in cultured rat islets of Langerhans-arginine-dependence and relationship to insulin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Antihypertensive Agents; Arginine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Kinetics; Molsidomine; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley | 1993 |
Initial biochemical and functional characterization of cyclic nucleotide phosphodiesterase isozymes in canine colonic smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Colforsin; Colon; Cyclic AMP; Cyclic GMP; Dogs; Isoenzymes; Muscle, Smooth; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rolipram | 1993 |
Multiple cis-acting domains mediate basal and adenosine 3',5'-monophosphate-dependent glucagon gene transcription in a mouse neuroendocrine cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; Glucagon; Intestinal Neoplasms; Mice; Mice, Transgenic; Neurosecretory Systems; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Phorbol ester stimulation of the type I and type III adenylyl cyclases in whole cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cell Line; Colforsin; Enzyme Activation; Gene Library; Humans; Isoenzymes; Kidney; Kinetics; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Bicarbonate induces sensitization of cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Astrocytoma; Bicarbonates; Blood Physiological Phenomena; Colforsin; Cyclic AMP; Humans; Magnesium; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Effect of forskolin and isobutylmethylxanthine on delta-opioid receptor activity in neuroblastoma x glioma NG108-15 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Colforsin; Cyclic AMP; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid Cells; Neuroblastoma; Protein Kinases; Receptors, Opioid, delta; Tumor Cells, Cultured | 1993 |
Determination of the response of melanoma cells to melanocyte stimulating hormone by 31P nuclear magnetic resonance spectroscopy.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Ethanolamines; Magnetic Resonance Spectroscopy; Melanocyte-Stimulating Hormones; Melanoma, Experimental; Perfusion; Phosphorylation; Phosphorylcholine; Tumor Cells, Cultured | 1993 |
Interleukin-6 production by rat granulosa cells in vitro: effects of cytokines, follicle-stimulating hormone, and cyclic 3',5'-adenosine monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Cytokines; Female; Follicle Stimulating Hormone; Granulosa Cells; In Vitro Techniques; Interleukin-1; Interleukin-6; Lipopolysaccharides; Progesterone; Rats; Second Messenger Systems; Tumor Necrosis Factor-alpha | 1993 |
Vasopressin increases density of apical low-conductance K+ channels in rat CCD.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Bucladesine; Colforsin; Cyclic AMP; Electric Conductivity; Female; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Male; Phosphorylation; Potassium Channels; Rats; Rats, Sprague-Dawley | 1993 |
Elevation of cAMP facilitates noradrenergic transmission in submucous neurons of guinea pig ileum.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Antagonists; Animals; Colforsin; Cyclic AMP; Dioxanes; Electric Stimulation; Ganglia; Guinea Pigs; Idazoxan; Ileum; Membrane Potentials; Microelectrodes; Neurons; Norepinephrine; Phentolamine; Receptors, Purinergic; Synaptic Transmission; Yohimbine | 1993 |
cAMP inhibition of interleukin-1-induced interleukin-6 production by human lung fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Bucladesine; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Fibroblasts; Humans; Interleukin-1; Interleukin-6; Lung; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1993 |
The effect of isobutylmethylxanthine, forskolin, and cholera toxin on growth hormone release from pituitary cell cultures of perinatal and mature rats.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Cells, Cultured; Cholera Toxin; Colforsin; Dose-Response Relationship, Drug; Female; Fetus; Growth Hormone; Male; Pituitary Gland; Rats; Rats, Sprague-Dawley | 1993 |
Effect of adenylate cyclase stimulation on meiotic resumption and cyclic AMP content of zona-free and cumulus-enclosed bovine oocytes in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cattle; Cell Nucleus; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dinoprostone; Female; Meiosis; Oocytes; Ovarian Follicle; Pertussis Toxin; Sodium Fluoride; Stimulation, Chemical; Virulence Factors, Bordetella; Zona Pellucida | 1993 |
Preferential coupling between dopamine D2 receptors and G-proteins.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Colforsin; Dopamine; GTP-Binding Proteins; Humans; Receptors, Dopamine; RNA Splicing; RNA, Messenger; Signal Transduction; Spiperone; Transfection; Tumor Cells, Cultured | 1993 |
Regulation of GABAA receptor in cerebellar granule cells in culture: differential involvement of kinase activities.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cerebellum; Chloride Channels; Colforsin; Cyclic AMP; Cytoplasmic Granules; Electrophysiology; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Membrane Proteins; Phosphorylation; Phosphotransferases; Picrotoxin; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Receptors, GABA-A | 1993 |
Synergistic regulation of vasoactive intestinal polypeptide expression by cyclic AMP and calcium in newborn but not adult rat sensory neurons in culture.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Animals, Newborn; Axons; Calcitonin Gene-Related Peptide; Calcium; Colforsin; Cyclic AMP; Female; Ganglia, Spinal; Immunohistochemistry; Male; Nerve Growth Factors; Neurons, Afferent; Rats; Rats, Wistar; Signal Transduction; Substance P; Vasoactive Intestinal Peptide | 1993 |
Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adult; Amiloride; Bronchi; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Electric Conductivity; Enzyme Activation; Epithelium; Female; Humans; Male | 1993 |
Effects of cAMP on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Brain Stem; Colforsin; Cyclic AMP; Neurons; Rats; Rats, Wistar; Respiratory Mechanics; Spinal Cord; Synapses; Synaptic Transmission | 1993 |
Cyclic adenosine monophosphate is not part of the transduction chain by which cell-swelling induces secretion in either normal or tumor-derived GH4C1 pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Size; Colforsin; Cyclic AMP; Hypotonic Solutions; Male; Osmolar Concentration; Pituitary Gland, Anterior; Pituitary Neoplasms; Potassium; Prolactin; Rats; Rats, Sprague-Dawley; Signal Transduction; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1993 |
Binding at an NFI site is modulated by cyclic AMP-dependent activation of myelin basic protein gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Binding Sites; Bucladesine; CCAAT-Enhancer-Binding Proteins; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; DNA; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Glioma; Kinetics; Molecular Sequence Data; Myelin Basic Protein; NFI Transcription Factors; Nuclear Proteins; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Rats; Restriction Mapping; Sequence Deletion; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Y-Box-Binding Protein 1 | 1993 |
Role of cyclic AMP in promoting the thromboresistance of human endothelial cells by enhancing thrombomodulin and decreasing tissue factor activities.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Base Sequence; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Dibutyryl Cyclic GMP; Endothelium, Vascular; Humans; Immunoenzyme Techniques; Kinetics; Microscopy, Immunoelectron; Molecular Sequence Data; Polymerase Chain Reaction; Receptors, Cell Surface; Receptors, Thrombin; RNA; RNA-Directed DNA Polymerase; Saphenous Vein; Thrombin; Thromboplastin; Thrombosis | 1993 |
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Aged; Bucladesine; Colforsin; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoenzymes; Lung; Lung Neoplasms; Male; Middle Aged; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Nitroprusside; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rolipram; Vital Capacity | 1993 |
Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Alprostadil; Autistic Disorder; Biological Transport; Blood Platelets; Child; Colforsin; Cyclic AMP; Female; Humans; In Vitro Techniques; Lysergic Acid; Male; Paroxetine; Platelet Count; Receptors, Serotonin; Serotonin | 1993 |
Regulated expression of an intestinal mucin gene in HT29 colonic carcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Bucladesine; Calcimycin; Colforsin; Colonic Neoplasms; DNA Probes; Ethers, Cyclic; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Ionomycin; Ionophores; Kinetics; Mucins; Okadaic Acid; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Structure-activity analysis of synthetic alpha-thrombin-receptor-activating peptides.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Cell Line; Colforsin; Cricetinae; Cricetulus; DNA Replication; Enzyme Activation; Fibroblast Growth Factor 2; Humans; Inositol Phosphates; Kinetics; Lung; Molecular Sequence Data; Oligopeptides; Receptors, Cell Surface; Receptors, Thrombin; Recombinant Proteins; Structure-Activity Relationship; Thrombin; Type C Phospholipases | 1993 |
Chronic treatment of newborn rats with naltrexone alters astrocyte production of nerve growth factor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Astrocytes; Brain; Cells, Cultured; Cerebellum; Colforsin; Corpus Striatum; Cyclic AMP; Female; Hippocampus; Male; Naltrexone; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1993 |
Cyclic adenosine monophosphate stimulates insulin-like growth factor binding protein-4 and its messenger ribonucleic acid in a clonal endothelial cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Bone and Bones; Bucladesine; Carrier Proteins; Cattle; Cell Line; Colforsin; Culture Media, Conditioned; Cyclic AMP; Endothelium; Glycosylation; Histamine; Immunosorbent Techniques; Insulin-Like Growth Factor Binding Protein 4; Kinetics; Parathyroid Glands; RNA, Messenger | 1993 |
The phagocytosis of rod outer segments is inhibited by drugs linked to cyclic adenosine monophosphate production.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Survival; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Isoproterenol; Phagocytosis; Pigment Epithelium of Eye; Rats; Rats, Mutant Strains; Rod Cell Outer Segment | 1993 |
Comparison of the effect of isobutylmethylxanthine and phosphodiesterase-selective inhibitors on cAMP levels in SH-SY5Y neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenylyl Cyclase Inhibitors; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Neuroblastoma; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Tumor Cells, Cultured | 1993 |
In vitro reorganization of porcine thyroid cells from the ATHOS line into follicle-like structures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Physiological Phenomena; Cell Differentiation; Cell Line; Colforsin; Collagen; Culture Media; Cyclic AMP; Microscopy, Electron; Swine; Thyroid Gland; Thyrotropin | 1993 |
Cyclic AMP mediates inhibition of the Na(+)-K+ electrogenic pump by serotonin in tactile sensory neurones of the leech.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Imines; Leeches; Membrane Potentials; Neurons, Afferent; Serotonin; Sodium; Sodium-Potassium-Exchanging ATPase; Touch | 1993 |
Calcium regulation of vasoactive intestinal polypeptide mRNA abundance in SH-SY5Y human neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Calcimycin; Calcium; Colforsin; Cyclic AMP; Gene Expression Regulation, Neoplastic; Humans; Neuroblastoma; Potassium; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1993 |
Involvement of cyclic adenosine monophosphate-dependent protein kinase isozymes in tissue plasminogen activator secretion by rat Sertoli cells stimulated with follicle-stimulating hormone in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Follicle Stimulating Hormone; Isoenzymes; Male; Phosphodiesterase Inhibitors; Protein Kinases; Rats; Sertoli Cells; Thionucleotides; Tissue Plasminogen Activator | 1993 |
Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Astrocytoma; Bradykinin; Brain Neoplasms; Calcimycin; Calcium; Calmodulin; Colforsin; Cyclic AMP; Dopamine; Egtazic Acid; Humans; Hydroquinones; Inositol 1,4,5-Trisphosphate; Neoplasm Proteins; Pyrrolidinones; Rolipram; Signal Transduction; Tumor Cells, Cultured | 1993 |
Regulation of two forms of the TNF receptors by phorbol ester and dibutyryl cyclic adenosine 3',5'-monophosphate in human histiocytic lymphoma cell line U-937.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Butyrates; Butyric Acid; Colforsin; Humans; Kinetics; Molecular Weight; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Interleukin-1-inducible expression of gro-beta via NF-kappa B activation is dependent upon tyrosine kinase signaling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Colforsin; Cytomegalovirus; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, jun; Genes, myc; Genistein; Growth Substances; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-1; Isoflavones; L Cells; Melanoma; Mice; Molecular Sequence Data; NF-kappa B; Oligonucleotide Probes; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1993 |
N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cerebellum; Colforsin; Cyclic AMP; Cycloleucine; Dipeptides; Glutamates; Glutamic Acid; Granulocytes; Inositol Phosphates; Receptors, Glutamate | 1993 |
Muscle membrane preparation restores sensitivity to acetylcholine in cultured chick ciliary ganglion neurons.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cycloheximide; Electrophysiology; Ganglia, Parasympathetic; Membranes; Muscles; Neurons; Protein Biosynthesis; Receptors, Cholinergic | 1993 |
The stimulation of vasopressin gene expression in cultured hypothalamic neurons by cyclic adenosine 3',5'-monophosphate is reversible.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Culture Media; Cyclic AMP; Gene Expression; Hypothalamus; Neurons; Rats; Rats, Sprague-Dawley; Time Factors; Vasopressins | 1993 |
Renin mRNA quantification using polymerase chain reaction in cultured juxtaglomerular cells. Short-term effects of cAMP on renin mRNA and secretion.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cells, Cultured; Colforsin; Cyclic AMP; Juxtaglomerular Apparatus; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Polymerase Chain Reaction; Renin; RNA, Messenger | 1993 |
A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Atrial Function, Left; Carbachol; Cardiotonic Agents; Colforsin; Cyclic AMP; Depression, Chemical; Electric Stimulation; Female; Heart; Heart Atria; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Pertussis Toxin; Potassium Channels; Rabbits; Receptors, Muscarinic; Virulence Factors, Bordetella | 1993 |
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cimetidine; Colforsin; Cyclic AMP; Gastric Acid; H(+)-K(+)-Exchanging ATPase; Histamine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Microscopy, Electron; Parietal Cells, Gastric; Protein Kinase Inhibitors; Rabbits; Sulfonamides | 1993 |
Lindane decreases forskolin-stimulated cyclic AMP accumulation but does not modify Gs in rat enterocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Autoradiography; Cell Membrane; Cholera Toxin; Colforsin; Cyclic AMP; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hexachlorocyclohexane; Intestinal Mucosa; Jejunum; Kinetics; Male; Membrane Proteins; Phorbol Esters; Phosphorus Radioisotopes; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1993 |
Calcitonin increases transcription of parathyroid hormone-related protein via cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Base Sequence; Bucladesine; Calcitonin; Colforsin; Cyclic AMP; Gene Expression Regulation, Neoplastic; Humans; Ionomycin; Lung Neoplasms; Molecular Sequence Data; Neoplasm Proteins; Parathyroid Hormone-Related Protein; Protein Biosynthesis; Proteins; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; RNA, Neoplasm; Second Messenger Systems; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
HS-142-1 inhibits testosterone production and guanosine-3':5'-cyclic monophosphate accumulation stimulated by atrial natriuretic peptide in isolated mouse Leydig cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Chorionic Gonadotropin; Colforsin; Cyclic GMP; Gene Expression Regulation; Leydig Cells; Male; Mice; Polysaccharides; Rats; Receptors, Atrial Natriuretic Factor; Second Messenger Systems; Testosterone | 1993 |
Leu-enkephalin modulates the migration inhibition of mouse splenocytes induced by cAMP-elevating agents.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Migration Inhibition; Cell Movement; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; In Vitro Techniques; Mice; Mice, Inbred CBA; Naloxone; Spleen; Theophylline | 1993 |
The adenylyl cyclase-cyclic AMP system modulates morphological and functional development of hypothalamic beta-endorphin neurons in culture.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; beta-Endorphin; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Drug Synergism; Hypothalamus; Immunoenzyme Techniques; Neurons; Rats; Rats, Sprague-Dawley | 1993 |
Existence of rolipram-sensitive phosphodiesterase in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Diphosphate; Adenylyl Cyclases; Animals; Bone Marrow Cells; Calcimycin; Calcium Channels; Colforsin; Cyclic AMP; Electrophysiology; Female; In Vitro Techniques; Inosine Triphosphate; Isoquinolines; Male; Megakaryocytes; Nystatin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Rolipram | 1993 |
Cyclic adenosine monophosphate acutely inhibits and chronically stimulates Na/H antiporter in OKP cells.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Bucladesine; Cell Line; Colforsin; Cyclic AMP; Cycloheximide; Hydrogen-Ion Concentration; Kidney; Kinetics; Opossums; Parathyroid Hormone; Sodium-Hydrogen Exchangers; Time Factors | 1993 |
Identification and regulation of whole-cell Cl- and Ca(2+)-activated K+ currents in cultured medullary thick ascending limb cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Line; Cell Membrane; Charybdotoxin; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Epithelial Cells; Epithelium; Kidney Tubules, Distal; Membrane Potentials; Potassium; Potassium Channels; Rabbits; Scorpion Venoms | 1993 |
Enhancers of cytosolic cAMP augment depolarization-induced exocytosis from pancreatic B-cells: evidence for effects distal to Ca2+ entry.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Electrophysiology; Exocytosis; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Thionucleotides | 1993 |
Neurohormonal regulation of histamine release from isolated rabbit fundic mucosal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcimycin; Carbachol; Colforsin; Diglycerides; Dose-Response Relationship, Drug; Gastric Fundus; Gastric Mucosa; Gastrins; Histamine Release; Male; Muscarinic Antagonists; Prostaglandins; Rabbits; Sincalide; Somatostatin; Tetradecanoylphorbol Acetate | 1993 |
Cyclic AMP plays a role in regulating HDL binding to human cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carrier Proteins; Cells, Cultured; Cholesterol; Colforsin; Cyclic AMP; Fibroblasts; Humans; Kinetics; Lipoproteins, HDL; Muscle, Smooth, Vascular; Receptors, Lipoprotein; RNA-Binding Proteins; Thionucleotides | 1993 |
Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Breast Neoplasms; Chloramphenicol O-Acetyltransferase; Colforsin; Dexamethasone; Ethers, Cyclic; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Genetic Vectors; Humans; Luciferases; Mammary Tumor Virus, Mouse; Okadaic Acid; Phosphopeptides; Phosphorylation; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Receptors, Glucocorticoid; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Prostaglandin E2 and other cyclic AMP elevating agents inhibit interleukin 2 gene transcription by counteracting calcineurin-dependent pathways.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcineurin; Calmodulin-Binding Proteins; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; Dinoprostone; Gene Deletion; Gene Expression; Humans; Interleukin-2; Ionomycin; Kinetics; Mice; Phosphoprotein Phosphatases; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Kinase C; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Forskolin and phorbol myristate acetate inhibit intracellular Ca2+ mobilization induced by amitriptyline and bradykinin in rat frontocortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Amitriptyline; Animals; Bradykinin; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Frontal Lobe; Imipramine; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Neurons; Piperazines; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate | 1993 |
Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diglycerides; Diterpenes; Dopamine D2 Receptor Antagonists; Ergolines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Protein Kinase C; Quinpirole; Raclopride; Receptors, Dopamine D2; Recombinant Proteins; Salicylamides; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Serotonin activation of a cyclic AMP-dependent sodium current in an identified neuron from Helisoma trivolvis.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Electric Conductivity; Membrane Potentials; Methysergide; Neurons; Serotonin; Snails; Sodium Channels | 1993 |
Indirect inhibition by bradykinin of cyclic AMP generation in isolated rat glomeruli and mesangial cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Bradykinin; Cells, Cultured; Colforsin; Cyclic AMP; Diglycerides; Dinoprostone; Down-Regulation; Drug Interactions; Enzyme Activation; Glomerular Mesangium; Isoproterenol; Kidney Glomerulus; Male; Pertussis Toxin; Protein Kinase C; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Infant, Newborn; Isoproterenol; Kinetics; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Protein Kinases; Signal Transduction | 1993 |
Functional roles of the nucleotide-binding folds in the activation of the cystic fibrosis transmembrane conductance regulator.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Chlorides; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; In Vitro Techniques; Ion Channels; Kinetics; Membrane Potentials; Membrane Proteins; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Protein Folding; Sequence Homology, Amino Acid; Xenopus laevis | 1993 |
Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Amino Acid Sequence; Animals; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction | 1993 |
cAMP and protein synthesis in isolated adult rat heart preparations.
Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Energy Metabolism; Epinephrine; Glucagon; Heart; Hypertension; In Vitro Techniques; Isoproterenol; Kinetics; Male; Myocardium; Perfusion; Phenylephrine; Phosphocreatine; Prazosin; Propranolol; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Yohimbine | 1993 |
Homologous desensitization of histamine H2 receptors in the human gastric carcinoma cell line MKN-45.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cimetidine; Colforsin; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Histamine; Histamine H2 Antagonists; Humans; Kinetics; Receptors, Histamine H2; Sodium Fluoride; Stomach Neoplasms; Tumor Cells, Cultured | 1993 |
cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Kinetics; Lung; Macromolecular Substances; Nitroprusside; Rats; RNA, Messenger | 1993 |
Opposite effects of cyclic AMP on the expression of the genes encoding ribonucleotide reductase in Swiss 3T3 and RAT 1 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Cycle; Cell Division; Cell Line; Colforsin; Cyclic AMP; DNA; Gene Expression Regulation, Enzymologic; Insulin; Mice; Rats; Ribonucleotide Reductases | 1993 |
Mechanism of melatonin signal transduction in the neonatal rat pituitary.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Calcimycin; Calcium; Colforsin; Cyclic AMP; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Melatonin; Nifedipine; Organ Culture Techniques; Pituitary Gland, Anterior; Rats; Receptors, Cell Surface; Receptors, Melatonin; Signal Transduction | 1995 |
Stimulation of cloned human serotonin 5-HT1D beta receptor sites in stably transfected C6 glial cells promotes cell growth.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Neoplasms; Bucladesine; Cell Division; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Genes; Glioma; Humans; Neoplasms; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombinant Proteins; Sequence Homology, Nucleic Acid; Serotonin Agents; Signal Transduction; Transfection; Tumor Cells, Cultured | 1996 |
Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics; Analgesics, Opioid; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Morphine; Naloxone; Pertussis Toxin; Phosphodiesterase Inhibitors; Rats; Receptors, Opioid, mu; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1995 |
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Male; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazines; Pyridazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Thiophenes | 1995 |
Impaired regulation of cell communication by beta-adrenergic receptor activation in the failing heart.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cardiomyopathies; Cell Communication; Colforsin; Cricetinae; Electric Conductivity; Gap Junctions; Heart; Heart Failure; Heart Ventricles; In Vitro Techniques; Isoproterenol; Male; Mesocricetus; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Receptors, Adrenergic, beta; Reference Values | 1996 |
Cyclic AMP prevents activation of a swelling-induced chloride-sensitive conductance in chick heart cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biotransformation; Cell Size; Chick Embryo; Chlorides; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Heart; Ion Channels; Myocardium; Okadaic Acid; Osmolar Concentration; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases | 1995 |
Activation of adenylyl cyclase downregulates sodium/calcium exchanger of arterial myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Arteries; Calcium-Transporting ATPases; Carrier Proteins; Cattle; Cell Membrane; Colforsin; Fetal Blood; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-myc; Rats; RNA, Messenger; Sodium-Calcium Exchanger | 1995 |
Effects of phosphodiesterase inhibitors and forskolin on cyclic GMP-activated channels in intact isolated cells of the chick pineal gland.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chick Embryo; Chickens; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Ion Channel Gating; Ion Channels; Papaverine; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pineal Gland | 1995 |
The controversial role of cAMP on amnionic prostaglandin release: effect of adenylate cyclase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amnion; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Female; Humans; Imines; Phospholipases A; Phospholipases A2; Pregnancy; Prostaglandins; Prostaglandins E | 1995 |
Corticotropin releasing factor binding protein (CRF-BP) is expressed in neuronal and astrocytic cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Carrier Proteins; Cells, Cultured; Colforsin; Immunoradiometric Assay; In Situ Hybridization; Microglia; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley | 1995 |
Down-regulation and differential restoration of cAMP responses upon transient phorbol ester treatment of primary osteoblastic cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Down-Regulation; Enzyme Activation; Kinetics; Osteoblasts; Parathyroid Hormone; Phorbol Esters; Phosphodiesterase Inhibitors; Protein Kinase C; Rats; Receptors, Parathyroid Hormone; Signal Transduction; Skull; Tetradecanoylphorbol Acetate | 1995 |
Activation of thyrotropin-releasing hormone gene expression in cultured fetal diencephalic neurons by differentiating agents.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Bromodeoxyuridine; Cells, Cultured; Colforsin; Diencephalon; Female; Fetus; Gene Expression Regulation, Developmental; Neurons; Pregnancy; Protein Precursors; Pyrrolidonecarboxylic Acid; Rats; RNA, Messenger; Somatostatin; Thyrotropin-Releasing Hormone | 1996 |
Inhibition of cyclic AMP accumulation by endothelin is pertussis toxin sensitive and calcium independent in isolated adult feline cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Calcium; Cardiotonic Agents; Cats; Cells, Cultured; Colforsin; Cyclic AMP; Endothelins; GTP-Binding Proteins; Heart; Isoproterenol; Myocardium; Pertussis Toxin; Phosphodiesterase Inhibitors; Sensitivity and Specificity; Virulence Factors, Bordetella | 1996 |
Inhibition of muscarinic stimulated phosphoinositide hydrolysis in the rat parotid gland by cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Animals; Calcium; Colforsin; Cyclic AMP; Dinoprostone; Drug Interactions; Hydrolysis; Isoproterenol; Male; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Parotid Gland; Phosphatidylinositols; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sodium Fluoride; Stimulation, Chemical | 1996 |
Inhibition of protein kinase A-induced glucagon synthesis and secretion by glucose.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Citrates; Citric Acid; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucose; Male; Rats; Streptozocin | 1996 |
Specific inhibition of basic calcium phosphate and calcium pyrophosphate crystal-induction of metalloproteinase synthesis by phosphocitrate.
Topics: 1-Methyl-3-isobutylxanthine; Aged; Animals; Blotting, Northern; Blotting, Western; Calcinosis; Calcium Phosphates; Cells, Cultured; Citrates; Colforsin; Crystallization; Cyclic AMP; DNA; DNA Probes; Enzyme Induction; Fibroblasts; Genes, jun; Humans; Male; Matrix Metalloproteinase 3; Metalloendopeptidases; Morbidity; Proto-Oncogene Proteins c-jun; Skin | 1996 |
The actions of prostaglandin E2 on potassium currents in rat tail artery vascular smooth muscle cells: regulation by protein kinase A and protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Male; Muscle, Smooth, Vascular; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Tail; Tetradecanoylphorbol Acetate | 1996 |
Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart. Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbachol; Cells, Cultured; Cholinergic Agonists; Colforsin; Cyclic AMP; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Heart; Isoproterenol; Kinetics; Male; Milrinone; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Pyridones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1996 |
Frequency modulation of acetylcholine-induced oscillations in Ca++ and Ca(++)-activated Cl- current by cAMP in tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Calcium; Chloride Channels; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; In Vitro Techniques; Isoproterenol; Male; Muscle, Smooth; Potassium Channels; Swine; Trachea | 1996 |
Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Cell Line; Cell Membrane; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Epithelium; Humans; Interferon-gamma; Interleukin-13; Interleukin-4; Intestines; Kinetics; L-Lactate Dehydrogenase; Recombinant Proteins | 1996 |
Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Cholera Toxin; Colforsin; Cricetinae; Cyclic AMP; DNA Primers; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression; Guanidines; Histamine; Histamine Agonists; Histamine H2 Antagonists; Iodine Radioisotopes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Protein Structure, Secondary; Radioligand Assay; Rats; Receptors, Histamine H2; Recombinant Proteins; RNA, Messenger; Transfection | 1996 |
Protein kinase C modulates natriuretic peptide receptors in astroglial cultures from rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Animals, Newborn; Astrocytes; Atrial Natriuretic Factor; Binding Sites; Brain Stem; Cells, Cultured; Colforsin; Cyclic GMP; Down-Regulation; Enzyme Inhibitors; Hypothalamus; Kinetics; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blotting, Northern; Cell Membrane; Chloride Channels; Cloning, Molecular; Colforsin; Epithelium; Female; Humans; Intestine, Small; Kidney; Liver; Membrane Potentials; Models, Structural; Molecular Sequence Data; Niflumic Acid; Oocytes; Organ Specificity; Patch-Clamp Techniques; Phylogeny; Polymerase Chain Reaction; Protein Structure, Secondary; Rabbits; Recombinant Proteins; Sequence Homology, Amino Acid; Xenopus laevis | 1996 |
Epidermal growth factor regulates adenylate cyclase activity via Gs and Gi1-2 proteins in pancreatic acinar membranes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Antibodies; Cell Membrane; Colforsin; Cyclic AMP; Epidermal Growth Factor; GTP-Binding Proteins; Humans; Kinetics; Pancreas; Rats; Recombinant Proteins; Vasoactive Intestinal Peptide | 1996 |
Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glucose; Hexokinase; Hexoses; Isoquinolines; Liver Neoplasms, Experimental; Mannoheptulose; Promoter Regions, Genetic; Rats; Signal Transduction; Sulfonamides; Transfection; Tumor Cells, Cultured | 1996 |
Cholera toxin enhances taurine uptake in cultures of human retinal pigment epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Carbazoles; Carrier Proteins; Cell Line; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indoles; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Phosphodiesterase Inhibitors; Pigment Epithelium of Eye; Pyrroles; Taurine | 1996 |
The cooperative interaction of two different signaling pathways in response to bufalin induces apoptosis in human leukemia U937 cells.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Agents; Apoptosis; Bufanolides; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Culture Media, Serum-Free; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Antisense; DNA, Neoplasm; Enzyme Activation; Humans; Kinetics; Leukemia; Mitogen-Activated Protein Kinase Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Signal Transduction; Time Factors; Tumor Cells, Cultured | 1996 |
The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Chlorocebus aethiops; Colforsin; DNA Probes; Down-Regulation; Endothelium, Vascular; Humans; Inflammation; Interleukin-1; Kinetics; Lipopolysaccharides; Receptor, PAR-2; Receptors, Cell Surface; Receptors, Thrombin; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha; Umbilical Veins | 1996 |
Bidirectional regulation of GABAA receptor alpha1 and alpha6 subunit expression by a cyclic AMP-mediated signalling mechanism in cerebellar granule cells in primary culture.
Topics: 1-Methyl-3-isobutylxanthine; Affinity Labels; Animals; Azides; Benzodiazepines; Bucladesine; Cells, Cultured; Cerebellum; Colforsin; Cyclic AMP; Neurons; Phosphodiesterase Inhibitors; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Signal Transduction; Tritium | 1996 |
Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Animals; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Glucose; Insulin; Male; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Rats | 1996 |
Anti-metastatic prostacyclins inhibit the adhesion of colon carcinoma to endothelial cells by blocking E-selectin expression.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Agents; Bucladesine; Carcinoma; Cell Adhesion; Cells, Cultured; Colforsin; Colonic Neoplasms; E-Selectin; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Epoprostenol; Humans; Neoplasm Metastasis; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 1996 |
Impaired cyclic AMP response to stimuli in glucose-desensitized rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Drug Tolerance; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 1995 |
Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Blotting, Western; Cattle; Cell Hypoxia; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; E-Selectin; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Kinetics; Lipopolysaccharides; RNA, Messenger; Thionucleotides; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1996 |
Activation of platelet-derived growth factor (PDGF) receptor dephosphorylation in intact Swiss 3T3 cells by elevators of intracellular Ca2+ and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Calcimycin; Calcium; Calcium-Transporting ATPases; Cell Division; Colforsin; Cyclic AMP; Enzyme Inhibitors; Kinetics; Mice; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Receptors, Platelet-Derived Growth Factor; Terpenes; Thapsigargin | 1996 |
Effects of parathyroid hormone and agonists of the adenylyl cyclase and protein kinase C pathways on bone cell proliferation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Amino Acid Sequence; Animals; Cell Division; Cells, Cultured; Colforsin; Culture Techniques; Enzyme Activation; Mice; Mice, Inbred ICR; Molecular Sequence Data; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Protein Kinase C; Signal Transduction; Teriparatide; Tetradecanoylphorbol Acetate | 1996 |
Effects of caffeine on Ca2+ fluxes and secretion in bovine chromaffin cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Medulla; Animals; Bucladesine; Caffeine; Calcium; Calcium-Transporting ATPases; Carbachol; Catecholamines; Cattle; Colforsin; Dimethylphenylpiperazinium Iodide; Inositol Phosphates; Nicotinic Agonists; Phosphodiesterase Inhibitors; Terpenes; Thapsigargin; Veratridine | 1995 |
Long-lasting synaptic facilitation induced by serotonin in superficial dorsal horn neurones of the rat spinal cord.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Colforsin; Electrophysiology; Naphthalenes; Neurons; Patch-Clamp Techniques; Phorbol Esters; Protein Kinase C; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Spinal Cord; Synapses; Tetrodotoxin | 1996 |
Different sites of action of arachidonic acid on steroidogenesis in rat Leydig cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Animals; Arachidonic Acid; Bucladesine; Colforsin; Cyclic AMP; GTP-Binding Proteins; Humans; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Pertussis Toxin; Placental Lactogen; Rats; Rats, Sprague-Dawley; Receptors, LH; Testosterone; Virulence Factors, Bordetella | 1996 |
Calcium controls second-messenger signalling in olfactory cilia.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Cilia; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Nasal Septum; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Signal Transduction | 1996 |
Effect of cAMP agonists on cell pH and anion transport by cultured rat inner medullary collecting duct cells.
Topics: 1-Methyl-3-isobutylxanthine; Acids; Animals; Anions; Antiporters; Biological Transport; Cells, Cultured; Chloride-Bicarbonate Antiporters; Colforsin; Cyclic AMP; Electric Conductivity; Female; Hydrogen; Hydrogen-Ion Concentration; Intracellular Membranes; Kidney Medulla; Kidney Tubules, Collecting; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers | 1996 |
Cyclic AMP-dependent pathway that mediates suppressive regulation of glycosaminoglycan production in cultured vascular endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Animals; Aorta; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Fibroblasts; Glucosamine; Glycosaminoglycans; Humans; L-Lactate Dehydrogenase; Swine | 1996 |
Involvement of pertussis toxin-sensitive and -insensitive G proteins in alpha-thrombin signalling on cultured human vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Alprostadil; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Muscle, Smooth, Vascular; Pertussis Toxin; Phosphatidylinositols; Poly(ADP-ribose) Polymerases; Saponins; Signal Transduction; Thrombin; Virulence Factors, Bordetella | 1996 |
Neurophysin expression is stimulated by dopamine D1 agonist in dispersed hypothalamic cultures.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cells, Cultured; Colforsin; Culture Media; Drug Combinations; Hypothalamus; Immunohistochemistry; Neurophysins; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Tissue Distribution; Vasopressins | 1996 |
The release of insulin-like growth factor-I by luteinized human granulosa cells in vitro: regulation by growth hormone, oxytocin, steroids and cAMP-dependent intracellular mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Estradiol; Female; Granulosa Cells; Growth Hormone; Humans; Insulin-Like Growth Factor I; Kinetics; Oxytocin; Progesterone; Steroids | 1995 |
Ascorbic acid augments the adenylyl cyclase-cAMP system mediated POMC mRNA expression and beta-endorphin secretion from hypothalamic neurons in culture.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Ascorbic Acid; beta-Endorphin; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Hypothalamus; Neurons; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
cAMP-dependent phosphorylation of the cardiac-type alpha 1 subunit of the voltage-dependent Ca2+ channel in a murine pancreatic beta-cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Calcium Channels, L-Type; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Gallopamil; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Macromolecular Substances; Mice; Myocardium; Phosphoproteins; Phosphorylation | 1996 |
Proliferation in the auditory receptor epithelium mediated by a cyclic AMP-dependent signaling pathway.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbazoles; Chickens; Cochlea; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Replication; Enzyme Activation; Enzyme Inhibitors; Gentamicins; Hair Cells, Auditory; Hearing Loss, Sensorineural; Indoles; Isoquinolines; Organ Culture Techniques; Pyrroles; Regeneration; Signal Transduction; Sulfonamides | 1996 |
Muscarinic autoinhibition of acetylcholine release in mouse atria is not transduced through cyclic AMP or protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenylyl Cyclases; Animals; Atrial Function; Atropine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Heart; Heart Atria; In Vitro Techniques; Male; Mice; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Muscarinic; Second Messenger Systems; Staurosporine | 1996 |
Differential activation of extracellular signal-regulated kinase (ERK) 1, ERK2, p38, and c-Jun NH2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Peptidoglycan; Phosphorylation; Protein Kinases | 1996 |
Chronic activation of the cyclic AMP signaling pathway promotes development and long-term survival of mesencephalic dopaminergic neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Bucladesine; Cell Division; Cell Survival; Cells, Cultured; Coculture Techniques; Colforsin; Cyclic AMP; Dopamine; Embryo, Mammalian; Kinetics; Mesencephalon; Neuroglia; Neurons; Rats; Rats, Wistar; Signal Transduction; Tyrosine 3-Monooxygenase | 1996 |
Modulation of islet G-proteins, alpha-glucosidehydrolase inhibition and insulin release stimulated by various secretagogues.
Topics: 1-Deoxynojirimycin; 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Cholera Toxin; Clonidine; Colforsin; Enzyme Inhibitors; Female; Glucosamine; Glucose; Glycoside Hydrolases; GTP-Binding Proteins; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mannoheptulose; Mice; Pertussis Toxin; Phosphodiesterase Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1996 |
Attenuation of cyclic AMP production by carbamazepine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Anticonvulsants; Carbamazepine; Cell Line; Cell Membrane; Cerebral Cortex; Chromatography, Affinity; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Glioma; Kinetics; Male; Pertussis Toxin; Phosphorylation; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1996 |
Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Down Syndrome; Female; Hippocampus; Isoproterenol; Mice; Phosphodiesterase Inhibitors | 1996 |
Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Anti-Inflammatory Agents; Colforsin; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucocorticoids; Interleukin-2; Marine Toxins; Mice; Oxazoles; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1996 |
Homologous regulation of the rat C1a calcitonin receptor (CTR) in nonosteoclastic cells is independent of CTR messenger ribonucleic acid changes and cyclic adenosine 3',5'-monophosphate-dependent protein kinase activation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Calcitonin; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Humans; Kidney; Kinetics; Osteosarcoma; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Receptors, Calcitonin; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Calcium Channels; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Oocytes; Xenopus | 1996 |
Adenylate cyclase in striatal cholinergic interneurons regulates acetylcholine release.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenylyl Cyclases; Animals; Colforsin; Corpus Striatum; Cyclic AMP; Interneurons; Male; Parasympathetic Nervous System; Rats | 1996 |
Stimulation of ouabain-sensitive 86Rb+ uptake and Na+,K+-ATPase alpha-subunit phosphorylation by a cAMP-dependent signalling pathway in intact cells from rat kidney cortex.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Ion Transport; Kidney Cortex; Kidney Tubules; Male; Ouabain; Phosphorylation; Rats; Rats, Wistar; Rubidium; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 1996 |
The amiloride inhibitable Na+ conductance of rat colonic crypt cells is suppressed by forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Chloride Channels; Chlorides; Colforsin; Colon; Down-Regulation; Electric Conductivity; Ion Transport; Membrane Potentials; Rats; Sodium; Sodium Channel Blockers; Sodium Channels | 1996 |
Potentiation of acetylcholine release from tracheal parasympathetic nerves by cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Colforsin; Cyclic AMP; Electric Stimulation; Horses; In Vitro Techniques; Isoproterenol; Parasympathetic Nervous System; Trachea | 1996 |
Prostaglandin E2 induction of binding activity to CRE and AP-2 elements in human T lymphocytes.
Topics: 1-Methyl-3-isobutylxanthine; Binding Sites; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dinoprostone; DNA; DNA-Binding Proteins; Enhancer Elements, Genetic; Enzyme Inhibitors; Humans; Jurkat Cells; Okadaic Acid; Phosphorylation; Promoter Regions, Genetic; T-Lymphocytes; Transcription Factor AP-2; Transcription Factors; Transfection | 1996 |
A regulatory role for cAMP-dependent protein kinase in protein traffic along the exocytic route.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Cell Compartmentation; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endoplasmic Reticulum; Enzyme Inhibitors; Exocytosis; Golgi Apparatus; Hexosaminidases; Isoquinolines; Membrane Glycoproteins; Microscopy, Electron; Protein Processing, Post-Translational; Rats; Sulfonamides; Viral Envelope Proteins | 1996 |
Cyclic AMP-induced desensitization of G-protein-regulated phospholipase C in turkey erythrocyte membranes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Drug Interactions; Erythrocytes; GTP-Binding Proteins; Isoproterenol; Phosphodiesterase Inhibitors; Sympathomimetics; Turkeys; Type C Phospholipases | 1996 |
Cholecystokinin (CCK) release from rat brain slices in vitro is enhanced by agents which elevate intracellular cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cholecystokinin; Colforsin; Cyclic AMP; Drug Interactions; Phosphodiesterase Inhibitors; Potassium; Prefrontal Cortex; Rats | 1996 |
Delta F508-CFTR channels: kinetics, activation by forskolin, and potentiation by xanthines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Glycosylation; Iodine; Mice; Mutation; Time Factors; Xanthines | 1996 |
Effect of PACAP, VIP, glucagon, and GLP1 on cAMP production and insulin release of HIT-T15 cells is passage dependent.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Line, Transformed; Colforsin; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Swine; Vasoactive Intestinal Peptide | 1996 |
Effect of the protein phosphatase inhibitor okadaic acid on FSH-induced granulosa cell steroidogenesis.
Topics: 1-Methyl-3-isobutylxanthine; 3-Hydroxysteroid Dehydrogenases; Animals; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Enzyme Activation; Female; Follicle Stimulating Hormone; Granulosa Cells; Okadaic Acid; Phosphoprotein Phosphatases; Progesterone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1997 |
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-1 Receptor Antagonists; Amino Acids; Animals; Animals, Newborn; Biological Transport; Bucladesine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Heart; Kinetics; Myocardium; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Sarcolemma | 1997 |
alpha-Toxin-permeabilised rabbit fetal ductus arteriosus is more sensitive to Ca2+ than aorta or main pulmonary artery.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aorta; Calcium; Colforsin; Cyclic AMP; Depression, Chemical; Dinoprostone; Ductus Arteriosus; Enzyme Activation; In Vitro Techniques; Muscle, Smooth, Vascular; Perfusion; Phosphodiesterase Inhibitors; Pulmonary Artery; Rabbits; Type C Phospholipases; Vasoconstriction | 1997 |
Suppression of the voltage-gated K+ current of human megakaryocytes by thrombin and prostacyclin.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Bone Marrow; Colforsin; Cyclic AMP; Egtazic Acid; Enzyme Inhibitors; Epoprostenol; GTP-Binding Proteins; Humans; Ion Channel Gating; Megakaryocytes; Membrane Potentials; Patch-Clamp Techniques; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Receptors, Thrombin; Thrombin; Thromboxane A2 | 1997 |
Facility changes mediated by cAMP in the bovine anterior segment in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anterior Chamber; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Bucladesine; Cattle; Colforsin; Cyclic AMP; Drug Antagonism; Epinephrine; In Vitro Techniques; Indomethacin; Mydriatics | 1997 |
Regulation of lipolysis by somatotropin: functional alteration of adrenergic and adenosine signaling in bovine adipose tissue.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Deaminase; Adipose Tissue; Adrenergic beta-Agonists; Animals; Bucladesine; Cattle; Colforsin; Culture Techniques; Dose-Response Relationship, Drug; Fasting; Female; Growth Hormone; GTP-Binding Proteins; Hypolipidemic Agents; Isoproterenol; Lactation; Lipolysis; Phenylisopropyladenosine; Signal Transduction | 1997 |
Aquaporins and ion conductance.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aquaporin 1; Aquaporins; Blood Group Antigens; Cations; Cell Membrane Permeability; Colforsin; Cyclic AMP; Humans; Ion Channels; Ion Transport; Oocytes; Patch-Clamp Techniques; RNA, Complementary; Water; Xenopus | 1997 |
Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucose-dependent insulinotropic polypeptide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Exocytosis; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Peptide Fragments; Phosphodiesterase Inhibitors; Tetradecanoylphorbol Acetate; Thionucleotides | 1997 |
Adenosine stimulation of DNA synthesis in human endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Endothelium, Vascular; Humans; Kinetics; Poly A; Purinergic P1 Receptor Antagonists; Quinazolines; Tetradecanoylphorbol Acetate; Thioinosine; Thionucleotides; Thymidine; Triazoles; Umbilical Veins | 1997 |
cAMP-mediated c-fos expression in pressure-overloaded acceleration of protein synthesis in adult rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Genes, fos; Glucagon; Isoquinolines; Male; Perfusion; Phosphodiesterase Inhibitors; Pressure; Protein Biosynthesis; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
GH3 cells expressing constitutively active Gs alpha (Q227L) show enhanced hormone secretion and proliferation.
Topics: 1-Methyl-3-isobutylxanthine; Blotting, Western; Bucladesine; Cell Count; Cell Division; Colforsin; Cyclic AMP; Enzyme Activation; Growth Hormone; GTP-Binding Proteins; Humans; Mutation; Prolactin; Thymidine; Transfection; Tumor Cells, Cultured | 1997 |
Repression of inducible nitric oxide synthase and cyclooxygenase-2 by prostaglandin E2 and other cyclic AMP stimulants in J774 macrophages.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Enzyme Repression; Isoenzymes; Lipopolysaccharides; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases | 1997 |
Roles of protein kinase A and C in spontaneous maturation and in forskolin or 3-isobutyl-1-methylxanthine maintained meiotic arrest of bovine oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Female; Indoles; Isoquinolines; Maleimides; Meiosis; Oocytes; Phorbol Esters; Protein Kinase C; Signal Transduction; Sulfonamides; Time Factors | 1996 |
cAMP modulation of a Ca2+-dependent K+ conductance in rat submandibular acinar cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcimycin; Calcium; Chlorides; Colforsin; Cyclic AMP; Electric Conductivity; Ion Channel Gating; Ionophores; Potassium; Rats; Salivation; Submandibular Gland; Tetraethylammonium; Tetraethylammonium Compounds | 1997 |
Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Chromosome Mapping; Chromosomes, Human, Pair 21; Colforsin; Cyclic AMP; Down Syndrome; Hippocampus; Humans; In Vitro Techniques; Isoproterenol; Kinetics; Mice; Mice, Neurologic Mutants; Norepinephrine; Organ Specificity; Propanolamines; Receptors, Adrenergic, beta; Reference Values; Signal Transduction | 1997 |
Role of the cyclic adenosine monophosphate-dependent protein kinase in the control of meiotic resumption in bovine oocytes cultured with thecal cell monolayers.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cattle; Cell Communication; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; In Vitro Techniques; Isoquinolines; Meiosis; Oocytes; Oogenesis; Phosphodiesterase Inhibitors; Signal Transduction; Sulfonamides; Theca Cells | 1997 |
Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; Liver; Mitogen-Activated Protein Kinases; Models, Biological; Polyenes; Protein Kinases; Rats; Recombinant Proteins; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Wortmannin | 1997 |
Regulation of superoxide production in human polymorphonuclear leukocytes (PMNs).
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Cytochalasin B; Dinoprostone; Epinephrine; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides | 1997 |
Dual action of cAMP-dependent protein kinase on granulocyte movement.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Antibodies, Monoclonal; CD18 Antigens; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Granulocytes; HL-60 Cells; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Thionucleotides | 1997 |
Mechanism of the impairment of the glucagon-stimulated phosphoenolpyruvate carboxykinase gene expression by interleukin-6 in rat hepatocytes: inhibition of the increase in cyclic 3',5' adenosine monophosphate and the downstream cyclic 3',5' adenosine mono
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Gene Expression Regulation, Enzymologic; Genes, Reporter; Glucagon; Interleukin-6; Liver; Male; Pertussis Toxin; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transfection; Virulence Factors, Bordetella | 1997 |
Evidence that activation of protein kinase A inhibits human hair follicle growth and hair fibre production in organ culture and DNA synthesis in human and mouse hair follicle organ culture.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Female; Hair; Hair Follicle; Humans; Mice; Organ Culture Techniques; Phosphodiesterase Inhibitors; Vibrissae | 1997 |
cAMP and forskolin inhibit potassium currents in rat taste receptor cells by different mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Bucladesine; Colforsin; Cyclic AMP; Female; In Vitro Techniques; Kinetics; Male; Patch-Clamp Techniques; Phosphorylation; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Taste Buds; Thionucleotides | 1997 |
cAMP decreases steady-state levels of delta-opioid receptor mRNA in NG108-15 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dinoprostone; Neuroblastoma; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Opioid, delta; RNA, Messenger; Rolipram | 1997 |
Stimulation of eating by the second messenger cAMP in the perifornical and lateral hypothalamus.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Diterpenes; Eating; Hypothalamic Area, Lateral; Male; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Stereotaxic Techniques; Thalamus | 1997 |
Rapid and long-term effects of PTH(1-34) on growth plate chondrocytes are mediated through two different pathways in a cell-maturation-dependent manner.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Alkaloids; Animals; Benzophenanthridines; Cattle; Cell Differentiation; Cells, Cultured; Chondrocytes; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Plate; Isoquinolines; Male; Parathyroid Hormone; Peptide Fragments; Phenanthridines; Phospholipases A; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 1997 |
[Early stages in mechanisms of glucocorticoids action on human thrombocytes: effect of hydrocortisone on intracellular cAMP and Ca2+].
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Blood Platelets; Calcium; Colforsin; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Glucocorticoids; Humans; Hydrocortisone; Intracellular Fluid; Phosphodiesterase Inhibitors; Radioligand Assay; Thapsigargin | 1997 |
Activation of adenylyl cyclase in human myometrial smooth muscle cells by neuropeptides.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adult; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Activation; Female; Humans; Muscle, Smooth; Myometrium; Neuropeptides; Phosphodiesterase Inhibitors | 1997 |
Protein kinase A and protein kinase C synergistically activate the Raf-1 kinase/mitogen-activated protein kinase cascade in neonatal rat cardiomyocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Bucladesine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Enzyme Activation; Isoproterenol; Myocardium; Protein Biosynthesis; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Rats, Wistar | 1997 |
The role of exocytosis in the activation of the chloride conductance in Chinese hamster ovary cells (CHO) stably expressing CFTR.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chloride Channels; CHO Cells; Colforsin; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Exocytosis; Female; Mutation; Ovary | 1997 |
PKA-mediated phosphorylation and inhibition of Na(+)-K(+)-ATPase in response to beta-adrenergic hormone.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Alanine; Animals; Cell Line; Colforsin; COS Cells; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Isoproterenol; Isoquinolines; Macromolecular Substances; Mutagenesis, Site-Directed; Okadaic Acid; Phosphorylation; Point Mutation; Rats; Recombinant Proteins; Rubidium; Serine; Sodium-Potassium-Exchanging ATPase; Spodoptera; Sulfonamides; Transfection | 1997 |
Troponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Calcium; Calcium-Binding Proteins; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Inhibitors; Heart; Heart Ventricles; Hypertension; Isoproterenol; Marine Toxins; Myocardial Contraction; Myocardium; Myosin Light Chains; Norepinephrine; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Troponin I | 1997 |
Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; Indoles; Isomerism; Isoproterenol; Kinetics; Liver; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Taurochenodeoxycholic Acid; Taurocholic Acid; Tetradecanoylphorbol Acetate | 1997 |
Adrenaline inhibits depolarization-induced increases in capacitance the presence of elevated [Ca2+]i in insulin secreting cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Colforsin; Egtazic Acid; Electric Conductivity; Epinephrine; Exocytosis; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Patch-Clamp Techniques; Pertussis Toxin; Rats; Tolbutamide; Virulence Factors, Bordetella | 1997 |
Involvement of cyclic GMP in the mode of action of a new antithrombotic agent PCA-4230; inhibition of the platelet cyclic GMP dependent phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Colforsin; Cyclic AMP; Cyclic GMP; Dihydropyridines; Drug Synergism; Fibrinolytic Agents; Kinetics; Nitroprusside; Phosphodiesterase Inhibitors; Phosphorylation; Rabbits; Serotonin; Thrombin; Vasodilator Agents | 1997 |
Cyclic AMP-mediated inhibition of angiotensin II-induced protein synthesis is associated with suppression of tyrosine phosphorylation signaling in vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Fibroblasts; Gene Expression Regulation; Humans; Isoproterenol; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Phosphotyrosine; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Transfection; Type C Phospholipases | 1997 |
Osmotic regulation of Na+ transport across A6 epithelium: interactions with prostaglandin E2 and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Activation; Epithelial Cells; Osmolar Concentration; Phosphodiesterase Inhibitors; Sodium Channels; Solutions; Water-Electrolyte Balance | 1997 |
Ryanodine receptor expression is associated with intracellular Ca2+ release in rat parotid acinar cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate Ribose; Animals; Base Sequence; Calcium; Calmodulin; Cells, Cultured; Colforsin; Cyclic ADP-Ribose; Cyclic AMP; Fluorescent Dyes; Gene Expression Regulation; Inositol 1,4,5-Trisphosphate; Kinetics; Molecular Sequence Data; Muscle, Skeletal; Parotid Gland; Polymerase Chain Reaction; Rats; RNA, Messenger; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sequence Alignment; Sequence Homology, Nucleic Acid; Sulfonamides | 1997 |
cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Capillaries; Cattle; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Isoproterenol; Isoquinolines; Lymphokines; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins c-raf; Signal Transduction; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
The role of cyclic AMP as a precursor of extracellular adenosine in the rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Animals; Colforsin; Cyclic AMP; Diterpenes; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine Monophosphate; Hippocampus; In Vitro Techniques; Male; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theophylline | 1997 |
Inhibitory effect of 2-phenyl-4-quinolone on serotonin-mediated changes in the morphology and permeability of endothelial monolayers.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Cattle; Cell Size; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Endothelium; Enzyme Inhibitors; Gap Junctions; Myocardium; Nitroprusside; Permeability; Protein Kinase C; Quinolones; Rats; Serotonin; Serum Albumin; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Inhibition of PAH transport by parathyroid hormone in OK cells: involvement of protein kinase C pathway.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Bucladesine; Cell Line; Cell Membrane; Colforsin; Kidney; Kinetics; Mannitol; p-Aminohippuric Acid; Protein Kinase C; Second Messenger Systems; Staurosporine; Teriparatide; Tetradecanoylphorbol Acetate | 1997 |
Denervation-induced supersensitivity to forskolin and pinacidil is not related to changes in the adenylate cyclase transduction pathway in the rabbit femoral artery.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cholera Toxin; Colforsin; Electrophoresis, Polyacrylamide Gel; Femoral Artery; Guanidines; In Vitro Techniques; Male; Muscle Denervation; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Phosphodiesterase Inhibitors; Pinacidil; Potassium Channels; Rabbits; Signal Transduction; Sympathectomy; Vasodilator Agents; Virulence Factors, Bordetella | 1997 |
Myocardial action potential prolongation by calcium channel activation under calcium free-EGTA conditions in guinea-pigs: developmental and regional variations.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Adrenergic beta-Agonists; Aging; Animals; Bucladesine; Calcium; Calcium Channels; Colforsin; Egtazic Acid; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Phosphodiesterase Inhibitors | 1997 |
Persistent desensitisation of the beta 2 adrenoceptors expressed by cultured equine sweat gland epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line, Transformed; Colforsin; Cyclic AMP; Epinephrine; Epithelial Cells; Horses; Protein Binding; Receptors, Adrenergic, beta-2; Sweat Glands; Time Factors | 1998 |
Effects of protein kinase modulators on the sodium pump activities of HeLa cells transfected with distinct alpha isoforms of Na,K-ATPase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; HeLa Cells; Humans; Isoenzymes; Kinetics; Ouabain; Protein Kinase C; Rats; Recombinant Proteins; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate; Transfection | 1997 |
Regulation of tumor necrosis factor alpha- and interleukin-1-beta-induced induced adhesion molecule expression in human vascular smooth muscle cells by cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Bucladesine; Cells, Cultured; Colforsin; Coronary Vessels; Cyclic AMP; Enzyme Activation; Epoprostenol; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-1; Muscle, Smooth, Vascular; Organ Specificity; Recombinant Proteins; RNA, Messenger; Saphenous Vein; Second Messenger Systems; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 1997 |
Phosphorylation modulates L-type Ca channels in frog ventricular myocytes by changes in sensitivity to Mg2+ block.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium Channels; Colforsin; Cyclic AMP; Cytidine Triphosphate; Electric Conductivity; Heart; Ion Channel Gating; Kinetics; Magnesium; Okadaic Acid; Patch-Clamp Techniques; Phosphorylation; Rana catesbeiana; Trypsin; Ventricular Function | 1998 |
cGMP facilitates calcium current via cGMP-dependent protein kinase in isolated rabbit ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Calcium Channels; Colforsin; Cyclic GMP; Electric Conductivity; Enzyme Inhibitors; Female; Heart; Isoproterenol; Male; Membrane Potentials; Protein Kinases; Rabbits; Thionucleotides | 1998 |
Sodium, potassium, two chloride cotransport in corneal endothelium: characterization and possible role in volume regulation and fluid transport.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Bumetanide; Carrier Proteins; Cattle; Cell Size; Cells, Cultured; Chlorides; Colforsin; Dose-Response Relationship, Drug; Endothelium, Corneal; Enzyme Inhibitors; Membrane Proteins; Ouabain; Potassium; Sodium; Sodium-Potassium-Chloride Symporters; Tetradecanoylphorbol Acetate | 1998 |
Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Line; Cell Membrane; Cell Polarity; Colforsin; Cyclic AMP; Epithelial Cells; Gene Expression Regulation; GTP-Binding Proteins; Kidney; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P1; Recombinant Proteins; Transfection | 1997 |
Cyclic AMP stimulates the cyclic GMP egression pump in human erythrocytes: effects of probenecid, verapamil, progesterone, theophylline, IBMX, forskolin, and cyclic AMP on cyclic GMP uptake and association to inside-out vesicles.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport, Active; Colforsin; Cyclic AMP; Cyclic GMP; Dimethyl Sulfoxide; Erythrocyte Membrane; Humans; Ion Pumps; Probenecid; Progesterone; Theophylline; Verapamil | 1998 |
Mechanism and regulation of riboflavin uptake by human renal proximal tubule epithelial cell line HK-2.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport; Bucladesine; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; Genistein; Humans; Isoquinolines; Kidney Tubules, Proximal; Kinetics; Nitriles; Protein Kinase C; Protein-Tyrosine Kinases; Riboflavin; Sulfonamides; Temperature; Tyrphostins | 1998 |
Role for cyclic adenosine monophosphate in modulating insulin-like growth factor binding protein secretion by muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Insulin; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor Binding Proteins; Intracellular Fluid; Mice; Muscles; Protein Binding; Rats | 1998 |
Regulation of vascular endothelial growth factor expression by cAMP in rat aortic smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclases; Animals; Aorta; Cobalt; Colforsin; Cyclic AMP; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Fibroblasts; Gene Expression Regulation; Iloprost; Isoproterenol; Lymphokines; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Rats; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Chlorides; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Jejunum; Levamisole; Mice; Mice, Mutant Strains; Phosphodiesterase Inhibitors; Rectum; Tetramisole; Trachea | 1998 |
Acute effects of thyroid hormones on the production of adrenal cAMP and corticosterone in male rats.
Topics: 1-Methyl-3-isobutylxanthine; 3-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Colforsin; Corticosterone; Cyclic AMP; Male; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Steroid 11-beta-Hydroxylase; Steroid 21-Hydroxylase; Thyroid Hormones; Thyroxine; Triiodothyronine | 1998 |
Phosphorylation of inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are differentially susceptible to phosphorylation and are phosphorylated in intact cells.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Calcium Channels; Carbachol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Humans; Inositol 1,4,5-Trisphosphate Receptors; Neuroblastoma; Neuropeptides; Peptide Fragments; Phosphorylation; Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1998 |
The second messenger cAMP elicits eating by an anatomically specific action in the perifornical hypothalamus.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Diterpenes; Eating; Hypothalamic Area, Lateral; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Second Messenger Systems | 1998 |
Protein kinases modulate two glycine currents in salamander retinal ganglion cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Ambystoma; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Isoquinolines; Kinetics; Kynurenic Acid; Membrane Potentials; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase C; Retinal Ganglion Cells; Strychnine; Sulfonamides | 1998 |
Cyclic AMP resets the circadian clock in cultured Xenopus retinal photoreceptor layers.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Circadian Rhythm; Colforsin; Cyclic AMP; Male; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Photoreceptor Cells; Retina; Thionucleotides; Xenopus laevis | 1998 |
The inhibition of DNA synthesis by prostaglandin E2 in human gingival fibroblasts is independent of the cyclic AMP-protein kinase A signal transduction pathway.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gingiva; Humans; Isoquinolines; Male; Phosphodiesterase Inhibitors; Signal Transduction; Sulfonamides; Up-Regulation | 1998 |
The effect of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and charybdotoxin (CTX) on relaxations of isolated cerebral arteries to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Cerebral Arteries; Charybdotoxin; Colforsin; Cyclic GMP; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Uridine Triphosphate | 1998 |
Contact-dependent cell interactions determine hormone responsiveness and desensitization in rat granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cell Aggregation; Cell Communication; Cell Count; Cholera Toxin; Colforsin; Cyclic AMP; Drug Tolerance; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Receptors, LH | 1998 |
A basolateral sorting signal is encoded in the alpha-subunit of Na-K-ATPase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Polarity; Colforsin; Cyclic AMP; H(+)-K(+)-Exchanging ATPase; LLC-PK1 Cells; Protein Conformation; Protein Sorting Signals; Recombinant Fusion Proteins; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Surface Properties; Swine; Transfection | 1998 |
Antibiotic accumulation and membrane trafficking in cystic fibrosis cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Adult; Cell Membrane; Child; Child, Preschool; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Energy Metabolism; Female; Fluorescein-5-isothiocyanate; Gentamicins; Humans; Male; Middle Aged; Nasal Polyps; Thionucleotides | 1998 |
Inhibition by gonadotropins of interleukin-1 production by rabbit granulosa and theca cells: effects on gonadotropin-induced progesterone production.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Division; Cells, Cultured; Cholera Toxin; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Female; Follicle Stimulating Hormone; Granulosa Cells; Humans; Interleukin-1; Mice; Phosphodiesterase Inhibitors; Progesterone; Rabbits; Theca Cells | 1998 |
Cyclic AMP, a mediator of GLP-1, acts in concert with glucose and tolbutamide to increase cytosolic Ca2+ in pancreatic B-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islets of Langerhans; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide | 1997 |
Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Kinetics; Mice; N-Methylaspartate; Narcotic Antagonists; Neuroblastoma; Neurons; Nociceptin; Nociceptin Receptor; Opioid Peptides; Rats; Receptors, Opioid; Signal Transduction | 1998 |
Cyclic AMP potentiates substance P-induced amylase secretion by augmenting the effect of calcium in the rat parotid acinar cells.
Topics: 1-Methyl-3-isobutylxanthine; 2,4-Dinitrophenol; Amylases; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Isoproterenol; Male; Parotid Gland; Perfusion; Phorbol 12,13-Dibutyrate; Rats; Rats, Wistar; Substance P; Thapsigargin | 1998 |
The in vitro effects of forskolin, IBMX and cyanoketone on meiotic maturation in follicle-enclosed catfish (Clarias batrachus) oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Catfishes; Colforsin; Cyanoketone; Cyclic AMP; Enzyme Activation; Female; Hydroxyprogesterones; Meiosis; Oocytes; Ovarian Follicle; Phosphodiesterase Inhibitors | 1996 |
Synergistic inhibition of vascular smooth muscle cell migration by phosphodiesterase 3 and phosphodiesterase 4 inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Animals; Aorta; Becaplermin; Cell Movement; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Humans; Kinetics; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Quinolones; Rats; Recombinant Proteins | 1998 |
alpha-Melanocyte stimulating hormone inhibits tumour necrosis factor-alpha stimulated intercellular adhesion molecule-1 expression in normal cutaneous human melanocytes and in melanoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Adult; alpha-MSH; Cell Culture Techniques; Colforsin; Culture Media, Conditioned; Female; Humans; Intercellular Adhesion Molecule-1; Melanocytes; Melanoma; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation | 1998 |
Differential regulation of N- and Q-type Ca2+ channels by cyclic nucleotides and G-proteins.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channel Blockers; Calcium Channels; Colforsin; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Nucleotides, Cyclic; omega-Conotoxin GVIA; Oocytes; Peptides; Phosphodiesterase Inhibitors; Xenopus | 1998 |
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Carrier Proteins; Central Nervous System; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Embryonic and Fetal Development; Gene Expression Regulation, Developmental; Hedgehog Proteins; Hindlimb; In Situ Hybridization; Mesoderm; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Molecular Sequence Data; Morphogenesis; Nuclear Proteins; Organ Culture Techniques; Paired Box Transcription Factors; PAX5 Transcription Factor; Proteins; Recombinant Proteins; Somites; Spinal Cord; Trans-Activators; Transcription Factors; Transforming Growth Factor beta | 1998 |
Beta-adrenergic signal transduction in the hypothalamus of the European hamster: relation with the seasonal hibernation cycle and the diurnal activity cycle.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arousal; Chlorides; Circadian Rhythm; Colforsin; Cricetinae; Cyclic AMP; Enzyme Activation; Guanylyl Imidodiphosphate; Hibernation; Hypothalamus; Imidazoles; Light; Male; Manganese Compounds; Propanolamines; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Seasons; Signal Transduction | 1997 |
Mucin-like glycoprotein secretion is mediated by cyclic-AMP and protein kinase C signal transduction pathways in rat corneal epithelium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbazoles; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelium, Corneal; Indoles; Male; Mucins; Naphthalenes; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction | 1998 |
P2X receptors in cochlear Deiters' cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cochlea; Colforsin; Dose-Response Relationship, Drug; Enzyme Activation; Guinea Pigs; Patch-Clamp Techniques; Protein Kinases; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Tetradecanoylphorbol Acetate; Thionucleotides; Uridine Triphosphate; Vasodilator Agents; Vestibular Nucleus, Lateral | 1998 |
Regulation of rhythmic melatonin production in pineal cells of chick embryo by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chick Embryo; Colforsin; Cyclic AMP; Melatonin; Phosphodiesterase Inhibitors; Pineal Gland | 1998 |
The role of cAMP in the actions of the peptide AF3 in the parasitic nematodes Ascaris suum and Ascaridia galli.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Ascaridia; Ascaris suum; Colforsin; Cyclic AMP; In Vitro Techniques; Muscle Contraction; Muscles; Oligopeptides; Second Messenger Systems | 1998 |
Effect of cAMP- and cGMP-related drugs on porcine cultured ciliary muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Bucladesine; Carbachol; Cells, Cultured; Ciliary Body; Colforsin; Cyclic AMP; Cyclic GMP; Immunoenzyme Techniques; Intraocular Pressure; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Nitroprusside; Phosphodiesterase Inhibitors; Swine | 1998 |
Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus--longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Animals; Benzoxazines; Calcium; Calcium Channel Blockers; Cannabinoids; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Intestine, Small; Male; Morphine Derivatives; Morpholines; Muscle Contraction; Myenteric Plexus; Naphthalenes; Phosphodiesterase Inhibitors; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1998 |
Cyclic AMP potentiates growth hormone-dependent differentiation of 3T3-F442A preadipocytes: possible involvement of the transcription factor CREB.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Drug Interactions; Glycerolphosphate Dehydrogenase; Growth Hormone; Ionomycin; Isoproterenol; Kinetics; Mice; Recombinant Proteins; Thionucleotides; Transcription Factors | 1998 |
A luciferase-engineered cell line for study of cAMP regulation in endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Antagonists; Animals; Aorta; Calcimycin; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Enhancer Elements, Genetic; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Isoproterenol; Isoquinolines; Kinetics; Luciferases; Rabbits; Signal Transduction; Sulfonamides; Transfection | 1998 |
Electrogenic bicarbonate secretion in mouse gallbladder.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bicarbonates; Bucladesine; Chlorides; Colforsin; Electric Conductivity; Epithelium; Gallbladder; Ionomycin; Ionophores; Membrane Potentials; Mice | 1998 |
Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Hypertension, Pulmonary; Hypoxia; Imidazoles; Male; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Pyrazines; Pyridones; Rats; Rats, Wistar; Vasodilation | 1998 |
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Morphogenetic Proteins; Brain-Derived Neurotrophic Factor; Cell Survival; Ciliary Neurotrophic Factor; Colforsin; Cyclic AMP; Estradiol; Glial Cell Line-Derived Neurotrophic Factor; Hepatocyte Growth Factor; Hydrocortisone; Hypoglycemic Agents; Insulin; Motor Neurons; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Oxygen; Phosphodiesterase Inhibitors; Progesterone; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Thyroxine; Tretinoin | 1998 |
Cystic fibrosis transmembrane conductance regulator activation by cAMP-independent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Benzimidazoles; Chlorophenols; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Genistein; Humans; Kinetics; Marine Toxins; Mice; Oxazoles; Phosphopeptides; Phosphorylation; Recombinant Proteins; Sequence Deletion; Transfection; Xanthines | 1998 |
Regulation of tyrosine hydroxylase gene expression during transdifferentiation of striatal neurons: changes in transcription factors binding the AP-1 site.
Topics: 1-Methyl-3-isobutylxanthine; Activating Transcription Factor 2; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Differentiation; Chamomile; Colforsin; Corpus Striatum; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Dopamine; Enzyme Inhibitors; Female; Fibroblast Growth Factor 1; Flavonoids; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; Neurons; Oils, Volatile; Phosphodiesterase Inhibitors; Plants, Medicinal; Pregnancy; Protein Binding; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Repressor Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Tyrosine 3-Monooxygenase | 1998 |
p53-dependent and -independent differentiation of leukemic U-937 cells: relationship to cell cycle control.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Differentiation; Cholecalciferol; Colforsin; Cyclic AMP; Genes, p53; Growth Inhibitors; Humans; Interferon-gamma; Leukemia, Monocytic, Acute; Tretinoin; Tumor Cells, Cultured | 1998 |
Forskolin-induced down-regulation of Na+,K(+)-ATPase activity is not associated with internalization of the enzyme.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Antimycin A; Binding Sites; Cell Membrane; Cells, Cultured; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Down-Regulation; Hydrolysis; Kidney; Ouabain; Phosphodiesterase Inhibitors; Phosphorylation; Rubidium; Sodium-Potassium-Exchanging ATPase | 1998 |
Regulation of cell cyclic AMP in medullary thick ascending limb of Henle in a rat model of chronic renal failure.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Calcitonin; Cell Separation; Clonidine; Colforsin; Creatinine; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Glomerular Filtration Rate; In Vitro Techniques; Kidney Failure, Chronic; Loop of Henle; Male; Osmolar Concentration; Rats; Rats, Wistar; Vasopressins | 1998 |
Pressure-induced expression of heat shock protein 70 mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression; Glucagon; HSP70 Heat-Shock Proteins; Hypertension; In Vitro Techniques; Isoquinolines; Male; Myocardium; Naphthalenes; Perfusion; Protein Biosynthesis; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Sulfonamides | 1998 |
Cystic fibrosis transmembrane conductance regulator-associated ATP release is controlled by a chloride sensor.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Chlorides; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Female; Gene Expression; Membrane Potentials; Oocytes; Xenopus laevis | 1998 |
Characteristics of amylase secretion induced by various secretagogues examined in perifused rat parotid acinar cells.
Topics: 1-Methyl-3-isobutylxanthine; Amylases; Animals; Bucladesine; Calcium; Carbachol; Cholinergic Agonists; Colforsin; Cyclic AMP; Epithelial Cells; Isoproterenol; Male; Norepinephrine; Parasympatholytics; Parotid Gland; Rats; Rats, Wistar; Substance P; Sympathomimetics; Temperature | 1998 |
Vasoactive intestinal peptide inhibits human small-cell lung cancer proliferation in vitro and in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Carcinoma, Small Cell; Cell Division; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Lung Neoplasms; Mice; Mice, Nude; Phosphodiesterase Inhibitors; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1998 |
Noradrenaline modulates the electrical activity of white adipocytes by a cAMP-dependent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Electrophysiology; Epididymis; Male; Membrane Potentials; Norepinephrine; Patch-Clamp Techniques; Potassium Channels; Rats; Vasoactive Intestinal Peptide | 1998 |
Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antibodies; Antigens, Surface; Breast Neoplasms; Chemotaxis; Colforsin; Culture Media, Conditioned; Cyclic AMP; Female; Fibroblasts; Humans; Integrin alpha6beta4; Integrins; Kinetics; Lysophospholipids; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Signal Transduction; Tumor Cells, Cultured | 1998 |
Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Carbachol; Colforsin; Cyclic AMP; Fasting; Female; Food Deprivation; Gastrectomy; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Parietal Cells, Gastric; Rats; Stomach; Tissue Extracts; Vagotomy | 1999 |
A family of cAMP-binding proteins that directly activate Rap1.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Glands; Adult; Amino Acid Sequence; Animals; Brain; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Fetus; Gene Expression; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Humans; In Situ Hybridization; Molecular Sequence Data; Phosphorylation; Proteins; rap GTP-Binding Proteins; ras Guanine Nucleotide Exchange Factors; Rats; Second Messenger Systems; Sequence Deletion; Signal Transduction | 1998 |
Modulation of angiogenic endothelial permselectivity by the cAMP pathway.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Allantois; Animals; Capillary Permeability; Cell Differentiation; Chick Embryo; Chorion; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dextrans; Endothelium, Vascular; Fluorescein-5-isothiocyanate; Image Processing, Computer-Assisted; Intercellular Junctions; Molecular Weight; Neovascularization, Physiologic; Phosphodiesterase Inhibitors; Second Messenger Systems; Thionucleotides | 1999 |
Regulation of natriuretic peptide (urodilatin) release in a human kidney cell line.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Calcimycin; Cell Line; Colforsin; Culture Media; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Humans; Intracellular Fluid; Kidney; Osmolar Concentration; Peptide Fragments; Radioimmunoassay; Tetradecanoylphorbol Acetate | 1999 |
cAMP mediates transepithelial K+ and Na+ transport in a strial marginal cell line.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Barium; Bucladesine; Cell Line; Colforsin; Cyclic AMP; Dibutyryl Cyclic GMP; In Vitro Techniques; Ion Channels; Ion Transport; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Second Messenger Systems; Sodium; Stria Vascularis | 1999 |
Modulation of nicotinic acetylcholine receptor activity in submucous neurons by intracellular messengers.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Colforsin; Enzyme Inhibitors; Genistein; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Neurons; Parasympatholytics; Phorbol Esters; Receptors, Nicotinic; Second Messenger Systems; Thapsigargin | 1999 |
Genistein inhibits slow component delayed-rectifier K currents via a tyrosine kinase-independent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electrophysiology; Genistein; Heart; In Vitro Techniques; Ion Exchange; Isoflavones; Isoproterenol; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Phenols; Phosphoric Diester Hydrolases; Potassium Channels; Protein-Tyrosine Kinases; Swine; Time Factors; Tyrphostins; Vanadates | 1998 |
Real-time evaluation of human secretin receptor activity using cytosensor microphysiometry.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biotinylation; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Isoquinolines; Microscopy, Fluorescence; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Secretin; Signal Transduction; Sulfonamides; Transfection | 1999 |
Phosphorylation of the small heat shock-related protein, HSP20, in vascular smooth muscles is associated with changes in the macromolecular associations of HSP20.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Colforsin; Heat-Shock Proteins; HSP20 Heat-Shock Proteins; Humans; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation | 1999 |
Alpha2-adrenoceptor-mediated enhancement of glycine response in rat sacral dorsal commissural neurons.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adrenergic alpha-Agonists; Animals; Bucladesine; Clonidine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Glycine Agents; GTP-Binding Proteins; Ion Channel Gating; Isoproterenol; Lumbosacral Region; Neurons, Afferent; Nociceptors; Norepinephrine; Pertussis Toxin; Phenylephrine; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Strychnine; Virulence Factors, Bordetella | 1999 |
Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Cell Line; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Mice; Milrinone; Mutation; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Thionucleotides; Xanthines | 1999 |
Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signaling pathway.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Bucladesine; Colforsin; Cyclic AMP; Dinoprostone; Enzyme Induction; Gene Expression Regulation; Humans; Interleukin-2; Janus Kinase 3; Phorbol 12,13-Dibutyrate; Protein-Tyrosine Kinases; Receptors, Interleukin-2; Recombinant Proteins; Second Messenger Systems; T-Lymphocytes | 1999 |
cAMP potentiates beta-amyloid-induced nitric oxide release from microglia.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Amyloid beta-Peptides; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Enzyme Activation; Microglia; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley | 1999 |
Serotonin, bradykinin and endothelin signalling in a sheep choroid plexus cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Calcium; Calcium Signaling; Cell Line; Choroid Plexus; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Endothelin-1; Receptors, Cell Surface; Serotonin; Sheep; Signal Transduction; Time Factors | 1999 |
[Intracellular regulation of neuronal nicotinic cholinergic receptors].
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase C; Rats; Receptors, Nicotinic; Superior Cervical Ganglion; Tetradecanoylphorbol Acetate; Thapsigargin | 1998 |
Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensitivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; ATP-Binding Cassette Transporters; beta-Galactosidase; Calcium Channels; Cells, Cultured; Chlorides; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Genetic Vectors; Glyburide; Humans; Ion Channel Gating; Moths; Nucleopolyhedroviruses; Patch-Clamp Techniques; Recombinant Fusion Proteins; Spodoptera; Xanthines | 1999 |
Modulation of rhythmic melatonin synthesis in Xenopus retinal photoreceptors by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Circadian Rhythm; Colforsin; Culture Techniques; Cyclic AMP; Enzyme Inhibitors; Male; Melatonin; Photoreceptor Cells, Vertebrate; Retina; Stimulation, Chemical; Thionucleotides; Xenopus laevis | 1999 |
Combined effects of caffeine and prostaglandin E2 on the proliferation of osteoblast-like cells (UMR106-01).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Osteoblasts; Periodontitis; Phosphodiesterase Inhibitors; Rats; Risk Factors; Time Factors | 1999 |
Downregulation of caveolin expression by cAMP signal.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caveolin 1; Caveolins; Cell Line; Cell Membrane; Colforsin; Cyclic AMP; Gene Expression Regulation; Kinetics; Membrane Proteins; Muscle, Smooth; Myocardium; Rats; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic | 1999 |
Effect of cAMP on the activity and the phosphorylation of Na+,K(+)-ATPase in rat thick ascending limb of Henle.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Bucladesine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Kidney Medulla; Loop of Henle; Male; Organ Culture Techniques; Oxygen; Phosphodiesterase Inhibitors; Phosphorylation; Quinacrine; Rats; Rats, Wistar; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Exchanging ATPase | 1999 |
P2 purinoceptors contribute to ATP-induced inhibition of L-type Ca2+ current in rabbit atrial myocytes.
Topics: 1-Methyl-3-isobutylxanthine; 5'-Nucleotidase; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Calcium-Transporting ATPases; Colforsin; Cyclic AMP; Enzyme Inhibitors; Isoproterenol; Myocardium; Patch-Clamp Techniques; Pertussis Toxin; Potassium Channels; Potassium Channels, Voltage-Gated; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2; Shal Potassium Channels; Suramin; Virulence Factors, Bordetella; Xanthines | 1999 |
Divergent mechanisms regulate proliferation/survival and steroidogenesis of theca-interstitial cells.
Topics: 1-Methyl-3-isobutylxanthine; 3-Hydroxysteroid Dehydrogenases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Division; Cell Survival; Cells, Cultured; Colforsin; Cyclic AMP; DNA; Female; Hormone Antagonists; Insulin-Like Growth Factor I; Luteinizing Hormone; Mifepristone; Progesterone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Testosterone; Tetradecanoylphorbol Acetate; Theca Cells | 1999 |
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines | 1999 |
Proximal promoter of the rat brain creatine kinase gene lacks a consensus CRE element but is essential for the cAMP-mediated increased transcription in glioblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Base Sequence; Brain; Colforsin; Consensus Sequence; Creatine Kinase; Cyclic AMP; DNA Probes; Gene Expression Regulation, Enzymologic; Glioblastoma; Humans; Introns; Nuclear Proteins; Promoter Regions, Genetic; Rats; Response Elements; RNA, Messenger; TATA Box; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1999 |
Regulation of human D1 dopamine receptor function and gene expression in SK-N-MC neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Benzazepines; Bucladesine; Cell Division; Colforsin; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Neuroblastoma; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, Dopamine D1; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1999 |
Various stimulators of the cyclic AMP pathway fail to promote adipose conversion of porcine preadipocytes in primary culture.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Glycerolphosphate Dehydrogenase; Mice; Stem Cells; Swine | 1999 |
Modulation of dihydropyridine-sensitive calcium channels in Drosophila by a cAMP-mediated pathway.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cesium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dihydropyridines; Drosophila; Enzyme Inhibitors; Isoquinolines; Larva; Membrane Potentials; Muscles; Mutagenesis; Nervous System; Phosphodiesterase Inhibitors; Sulfonamides | 1999 |
Cyclic AMP regulates the expression of neurokinin1 receptors by neonatal rat spinal neurons in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dibutyryl Cyclic GMP; Gene Expression Regulation; Inositol Phosphates; Iodine Radioisotopes; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Spinal Cord; Substance P; Succinimides | 1999 |
Calcium regulation of cyclic nucleotide signaling in lobster olfactory receptor neurons.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Blotting, Western; Calcium; Calcium Channels; Cell Membrane; Colforsin; Cyclic AMP; Dendrites; Inositol 1,4,5-Trisphosphate; Ion Channel Gating; Nephropidae; Odorants; Olfactory Receptor Neurons; Signal Transduction | 1999 |
Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Calcium; Cell Line; Cell Membrane; Chemokine CCL5; Chemotaxis; Cloning, Molecular; Colforsin; Cyclic AMP; Evolution, Molecular; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Models, Molecular; Molecular Sequence Data; Pertussis Toxin; Protein Structure, Secondary; Receptors, CCR5; Receptors, CXCR4; Recombinant Proteins; Sequence Alignment; Transfection; Virulence Factors, Bordetella | 1999 |
Heterotrimetric Gi/o proteins control cyclic AMP oscillations and cytoskeletal structure assembly in primary human granulosa-lutein cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Blotting, Northern; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Cytoskeleton; Dimerization; Female; Fluorescent Antibody Technique; Follicle Stimulating Hormone; Granulosa Cells; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Humans; Luteal Cells; Luteinizing Hormone; Pertussis Toxin; Staining and Labeling; Virulence Factors, Bordetella | 1999 |
Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Bucladesine; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Enzyme Activation; Female; Fibroblasts; Gene Expression Regulation; Humans; In Situ Hybridization; Male; Matrix Metalloproteinase 13; Middle Aged; Phosphodiesterase Inhibitors; Radiography; RNA, Messenger; Synovial Membrane | 1999 |
Roles of prostaglandin E receptors in mesangial cells under high-glucose conditions.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Anti-Ulcer Agents; Blotting, Northern; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Dinoprostone; Gene Expression; Glomerular Mesangium; Glucose; Male; Menstruation-Inducing Agents; Phosphodiesterase Inhibitors; Prostaglandins E, Synthetic; Rats; Rats, Inbred WKY; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; RNA, Messenger; Thymidine; Tritium | 1999 |
Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Androgens; Biomarkers; Bombesin; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Lineage; Chromogranin A; Chromogranins; Colforsin; Cyclic AMP; Cytoplasmic Granules; Dihydrotestosterone; Disease Progression; Epinephrine; Humans; Isoproterenol; Male; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Neoplastic Stem Cells; Neuroendocrine Tumors; Neurotensin; Parathyroid Hormone-Related Protein; Phenotype; Phosphopyruvate Hydratase; Prostatic Neoplasms; Protein-Tyrosine Kinases; Proteins; Second Messenger Systems; Serotonin; Tumor Cells, Cultured | 1999 |
Differential regulation of extracellular signal-regulated protein kinases (ERKs) 1 and 2 by cAMP and dissociation of ERK inhibition from anti-mitogenic effects in rabbit vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Becaplermin; Cell Cycle Proteins; Cells, Cultured; Colforsin; Cyclic AMP; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Gene Expression Regulation; Genes, myc; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rabbits; RNA, Messenger; Transforming Growth Factor beta; Tumor Suppressor Proteins | 1999 |
Differential regulation of cyclooxygenase isoenzymes by cAMP-elevating agents.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Arachidonic Acid; Blotting, Western; Bucladesine; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Isoenzymes; Lipopolysaccharides; Okadaic Acid; Prostaglandin-Endoperoxide Synthases; Proteins; Thionucleotides | 1999 |
The biphasic induction of p21 and p27 in breast cancer cells by modulators of cAMP is posttranscriptionally regulated and independent of the PKA pathway.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cell Cycle Proteins; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Female; Humans; Isoquinolines; Kinetics; Lovastatin; Microtubule-Associated Proteins; Protein Processing, Post-Translational; Sulfonamides; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1999 |
Sequential changes in autonomic regulation of cardiac myocytes after in vivo endotoxin injection in rat.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Adenylyl Cyclases; Adrenergic Antagonists; Adrenergic beta-Agonists; Animals; Autonomic Nervous System; Calcium Channel Agonists; Calcium Channels, L-Type; Colforsin; Diterpenes; Electrophysiology; Endotoxemia; Endotoxins; Enzyme Activators; Escherichia coli; Heart; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Isoproterenol; Male; Myocardium; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rats; Sepsis | 1999 |
Interactions between Ca2+ and cAMP in ecdysteroid secretion from the prothoracic glands of Bombyx mori.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bombyx; Bucladesine; Calcimycin; Calcium; Colforsin; Cyclic AMP; Drug Interactions; Ecdysterone; Enzyme Inhibitors; Phosphodiesterase Inhibitors; Second Messenger Systems; Signal Transduction; Thionucleotides; Verapamil | 1999 |
Developmental changes in renal renin mRNA half-life and responses to stimulation in fetal lambs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Dactinomycin; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Fetus; Half-Life; Isoproterenol; Kidney; Kidney Cortex; Nucleic Acid Synthesis Inhibitors; Renin; RNA Stability; RNA, Messenger; Sheep; Transcription, Genetic | 1999 |
Basic fibroblast growth factor stimulates repair of wounded hepatocyte monolayer: modulatory role of protein kinase A and extracellular matrix.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Actins; Animals; Blotting, Western; Cell Division; Cell Movement; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Epithelial Cells; Extracellular Matrix; Fibroblast Growth Factor 2; Liver; Mitomycin; Nucleic Acid Synthesis Inhibitors; Phosphodiesterase Inhibitors; Rats; Receptors, Fibroblast Growth Factor; Stress, Mechanical; Tritium; Wound Healing | 1999 |
Development of human and rabbit vaginal smooth muscle cell cultures: effects of vasoactive agents on intracellular levels of cyclic nucleotides.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Alprostadil; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Female; Humans; Isoproterenol; Muscle, Smooth; Nitroprusside; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Piperazines; Purines; Rabbits; Sildenafil Citrate; Sulfones; Vagina; Vasoactive Intestinal Peptide; Vasodilator Agents | 1999 |
Protein tyrosine kinase is required for the induction of long-term potentiation in the rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; Hypoxia; In Vitro Techniques; Long-Term Potentiation; Male; Phenols; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Tetraethylammonium | 1999 |
Exogenous cyclic AMP, cholera toxin, and endotoxin induce expression of the lipopolysaccharide receptor CD14 in murine bone marrow cells: role of purinoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Binding, Competitive; Bone Marrow Cells; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Enzyme Inhibitors; Female; Lipopolysaccharide Receptors; Lipopolysaccharides; Mice; Mice, Inbred C3H; Phosphodiesterase Inhibitors; Receptors, Purinergic; Second Messenger Systems; Thionucleotides; Tritium; Trypsin | 1999 |
Interaction between calcium-activated chloride channels and the cystic fibrosis transmembrane conductance regulator.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cattle; Cell Line; Cell Membrane; Chloride Channels; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Endothelium, Vascular; Gene Expression; Mutation; Pulmonary Artery; Transfection | 1999 |
Long-wavelength iodide-sensitive fluorescent indicators for measurement of functional CFTR expression in cells.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Biological Transport; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Fluorescent Dyes; Iodides; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Phosphodiesterase Inhibitors; Photochemistry; Pteridines; Quinolinium Compounds; Ribose; Thionucleotides | 1999 |
Increase of urinary extracellular-superoxide dismutase level correlated with cyclic adenosine monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylglucosaminidase; Adenosine Triphosphate; Bucladesine; Colforsin; Cyclic AMP; Extracellular Space; Fibroblasts; Humans; Isoenzymes; Kidney Tubules; Mutation; Parathyroid Hormone; Phosphates; Proteinuria; Superoxide Dismutase | 1999 |
Ceramide enhances growth hormone (GH)-releasing hormone-stimulated cyclic adenosine 3',5'-monophosphate accumulation but inhibits GH release in rat anterior pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Ceramides; Colforsin; Cyclic AMP; Glucosyltransferases; Growth Hormone; Growth Hormone-Releasing Hormone; Ionomycin; Ionophores; Male; Meperidine; Pituitary Gland, Anterior; Potassium Chloride; Rats; Rats, Sprague-Dawley | 1999 |
Ca(2+) and extracellular acidification rate responses to parathyroid hormone fragments in rat ROS 17/2 and human SaOS-2 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Benzophenanthridines; Calcium; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Fura-2; Humans; Hydrogen-Ion Concentration; Kinetics; Parathyroid Hormone; Peptide Fragments; Phenanthridines; Protein Kinase C; Rats; Signal Transduction; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1999 |
Kinase-dependent regulation of the intermediate conductance, calcium-dependent potassium channel, hIK1.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Biological Transport; Calcium; Calcium Signaling; Cell Membrane; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electric Conductivity; Epithelial Cells; Intermediate-Conductance Calcium-Activated Potassium Channels; Ion Channel Gating; Ionomycin; Ionophores; Oocytes; Patch-Clamp Techniques; Peptide Fragments; Phosphorylation; Potassium Channels; Potassium Channels, Calcium-Activated; Xenopus | 2000 |
PhosphoCREB and CREM/ICER: positive and negative regulation of proenkephalin gene expression in the paraventricular nucleus of the hypothalamus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; beta-Galactosidase; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Enkephalins; Escherichia coli; Gene Expression Regulation; Interleukin-1; Kinetics; Lipopolysaccharides; Male; Mice; Mice, Transgenic; Muscimol; Neurons; Paraventricular Hypothalamic Nucleus; Phosphorylation; Protein Precursors; Recombinant Proteins; Repressor Proteins; RNA, Messenger; Transcription, Genetic | 1999 |
Allatotropic activity in the suboesophageal ganglia and corpora cardiaca of the adult male loreyi leafworm, Mythimna loreyi.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Dose-Response Relationship, Drug; Female; Ganglia, Invertebrate; Insect Hormones; Lepidoptera; Male; Neuropeptides; Neurosecretory Systems; Second Messenger Systems | 2000 |
Curosurf modulates cAMP accumulation in human monocytes through a membrane-controlled mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Bacterial Proteins; Biological Products; Cell Membrane; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Drug Combinations; Humans; Intracellular Membranes; Monocytes; Phosphodiesterase Inhibitors; Phospholipids; Protein Precursors; Proteolipids; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants | 2000 |
Induction of arginase II in human Caco-2 tumor cells by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Arginase; Caco-2 Cells; Colforsin; Cyclic AMP; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Isoquinolines; Kinetics; Okadaic Acid; Protein Biosynthesis; RNA, Messenger; Sulfonamides; Transcription, Genetic | 2000 |
Induction of gap junctional intercellular communication, connexin43 expression, and subsequent differentiation in human fetal neuronal cells by stimulation of the cyclic AMP pathway.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Blotting, Western; Cell Communication; Cell Differentiation; Cell Line; Colforsin; Connexin 43; Cyclic AMP; Fetus; Fluorescent Antibody Technique; Gap Junctions; Humans; Intercellular Junctions; Nerve Tissue Proteins; Neuroglia; Neurons; Rats; Rats, Inbred F344 | 2000 |
Dopamine induces a biphasic modulation of hypothalamic ANF neurons: a ligand concentration-dependent effect involving D5 and D2 receptor interaction.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Antibodies; Atrial Natriuretic Factor; Benzazepines; Biological Transport; Blotting, Northern; Bucladesine; Cells, Cultured; CHO Cells; Colforsin; Cricetinae; Dopamine; Dopamine Agonists; Dopamine Antagonists; Gene Expression; GTP-Binding Proteins; Hypothalamus; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Ligands; Neurons; Peptides; Phosphodiesterase Inhibitors; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D5; RNA, Messenger; Staining and Labeling; Wasp Venoms | 2000 |
Cyclic AMP regulates substance P expression in developing and mature spinal sensory neurons.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; Cellular Senescence; Colforsin; Cyclic AMP; Ganglia, Spinal; Nerve Growth Factor; Neurons, Afferent; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin; Substance P; Tachykinins | 2000 |
The role of phosphodiesterase in mediating the effect of protein kinase C on cyclic AMP accumulation upon kappa-opioid receptor stimulation in the rat heart.
Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alkaloids; Animals; Benzophenanthridines; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Male; Myocardium; Phenanthridines; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tetradecanoylphorbol Acetate | 2000 |
The cyclic AMP-protein kinase A pathway restrains islet phospholipase A(2) activation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Carbachol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Melitten; Peptide Fragments; Phospholipases A; Protein Precursors; Rats; Rats, Sprague-Dawley; Signal Transduction; Sincalide; Vasoactive Intestinal Peptide | 2000 |
Oxidized-low density lipoprotein inhibits cyclic AMP production by porcine luteal cells.
Topics: 1-Methyl-3-isobutylxanthine; Adjuvants, Immunologic; Animals; Cholera Toxin; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Female; Immunoenzyme Techniques; Lipoproteins, LDL; Luteal Cells; Oxidation-Reduction; Swine | 2000 |
Role of cAMP in the short-term modulation of a neuromuscular system in aplysia.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Aplysia; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Inhibitors; Invertebrate Hormones; Motor Neurons; Muscle Contraction; Muscles; Neural Pathways; Neuromuscular Junction; Neuropeptides; Phorbol Esters; Serotonin | 2000 |
Direct effects of prolactin on corticosterone release by zona fasciculata-reticularis cells from male rats.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Animals; Bromocriptine; Cells, Cultured; Cerebral Cortex; Colforsin; Corticosterone; Cyclic AMP; Desoxycorticosterone; Hyperprolactinemia; Injections, Subcutaneous; Male; Nifedipine; Pituitary Gland, Anterior; Pregnenolone; Progesterone; Prolactin; Rats; Rats, Sprague-Dawley; Sheep; Zona Fasciculata; Zona Reticularis | 1999 |
CAMP inhibits mitogen-activated protein (MAP) kinase activation and resumption of meiosis, but exerts no effects after spontaneous germinal vesicle breakdown (GVBD) in mouse oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Female; Meiosis; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Naphthalenes; Okadaic Acid; Oocytes; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Phosphatase 1 | 1999 |
Regulation of mouse delta-opioid receptor gene transcription: involvement of the transcription factors AP-1 and AP-2.
Topics: 1-Methyl-3-isobutylxanthine; Aged; Animals; Carcinogens; Colforsin; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Genetic Complementation Test; Glioma; Humans; Mice; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Protein Kinase C; Receptor Cross-Talk; Receptors, Opioid, delta; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factor AP-2; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
The role of cyclic nucleotides in the spontaneous contractility and responsiveness to nitric oxide of the rat uterus at midgestation and term.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Myometrium; Nitric Oxide; Papaverine; Phosphodiesterase Inhibitors; Pregnancy; Rats; Rats, Sprague-Dawley; Uterine Contraction; Uterus | 2000 |
Direct measurement of hormone-induced acidification in intact bone.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Animals, Newborn; Bone and Bones; Bone Neoplasms; Bucladesine; Calcium Signaling; Carbonic Anhydrases; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Extracellular Space; Humans; Hydrogen-Ion Concentration; Mice; Organ Culture Techniques; Organ Specificity; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Protein Kinase C; Second Messenger Systems; Skull; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 2000 |
Deactivation of TSH receptor signaling in filter-cultured pig thyroid epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Diuretics; Electrolytes; Epithelial Cells; Filtration; Furosemide; Kinetics; Receptors, Thyrotropin; Signal Transduction; Swine; Thyroid Gland; Trypsin | 2000 |
Cyclic AMP signaling functions as a bimodal switch in sympathoadrenal cell development in cultured primary neural crest cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Glands; Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Division; Cell Lineage; Cells, Cultured; Colforsin; Coturnix; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Drosophila Proteins; Homeodomain Proteins; Immunohistochemistry; Models, Biological; Nerve Tissue Proteins; Neural Crest; Norepinephrine; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factors; Transforming Growth Factor beta | 2000 |
Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Clone Cells; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dogs; Hepatocyte Growth Factor; Kidney; Kidney Neoplasms; Kidney Tubules; Macromolecular Substances; Microscopy, Immunoelectron; Polycystic Kidney Diseases; Recombinant Proteins; Signal Transduction; Subcellular Fractions | 2000 |
Effects of estradiol on corticosterone secretion in ovariectomized rats.
Topics: 1-Methyl-3-isobutylxanthine; 17-Hydroxysteroid Dehydrogenases; Adrenocorticotropic Hormone; Animals; Cells, Cultured; Chromatography, Thin Layer; Colforsin; Corticosterone; Cyclic AMP; Dose-Response Relationship, Drug; Estradiol; Female; Mixed Function Oxygenases; Ovariectomy; Ovary; Phosphodiesterase Inhibitors; Prolactin; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Steroid 11-beta-Hydroxylase; Zona Fasciculata | 2000 |
Wortmannin, a PI3-kinase inhibitor: promoting effect on insulin secretion from pancreatic beta cells through a cAMP-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Colforsin; Cyclic AMP; Enzyme Inhibitors; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Perfusion; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Wistar; Signal Transduction; Wortmannin | 2000 |
Regulation of tryptophan hydroxylase activity in Xenopus laevis photoreceptor cells by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Enzyme Activation; Female; Light; Nucleic Acid Synthesis Inhibitors; Phosphodiesterase Inhibitors; Photoreceptor Cells, Vertebrate; Protein Synthesis Inhibitors; Retina; RNA, Messenger; Tryptophan Hydroxylase; Xenopus laevis | 2000 |
Zinc modulates the electro-olfactogram of the frog.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Electrophysiology; In Vitro Techniques; Menthol; Odorants; Olfactory Mucosa; Pentanols; Rana catesbeiana; Terpenes; Zinc | 2000 |
Analyses of signal transduction cascades reveal an essential role of calcium ions for regulation of melatonin biosynthesis in the light-sensitive pineal organ of the rainbow trout (Oncorhynchus mykiss).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arylamine N-Acetyltransferase; Calcium; Calcium Signaling; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cysteine Endopeptidases; Female; Gene Expression; Immunohistochemistry; Male; Melatonin; Multienzyme Complexes; Oncorhynchus mykiss; Organ Culture Techniques; Phosphodiesterase Inhibitors; Phosphorylation; Photic Stimulation; Pineal Gland; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Signal Transduction; Transcription, Genetic | 2000 |
Alpha-melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Colforsin; Cytokines; Enzyme Activation; Enzyme Inhibitors; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Keratinocytes; Melanoma; NF-kappa B; Oxidative Stress; Peptide Fragments; Peroxides; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
The secretory response of the rat colon to the flavonol quercetin is dependent on Ca2+-calmodulin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Calmodulin; Carbachol; Chlorides; Colforsin; Colon; Diffusion Chambers, Culture; Indicators and Reagents; Intestinal Mucosa; Male; Muscarinic Agonists; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Quercetin; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 2000 |
Role of cyclic AMP in idiopathic nephrotic syndrome: a pathway involving a decrease in glomerular cell heparan sulfates?
Topics: 1-Methyl-3-isobutylxanthine; Adult; Animals; Antimetabolites; Cells, Cultured; Child; Child, Preschool; Colforsin; Creatinine; Cyclic AMP; Dideoxyadenosine; Glomerular Mesangium; Heparitin Sulfate; Humans; Nephrotic Syndrome; Phosphodiesterase Inhibitors; Plasma; Rats; Rats, Sprague-Dawley; Signal Transduction; Statistics, Nonparametric; Urine | 2000 |
The cAMP-dependent kinase pathway does not sensitize the cloned vanilloid receptor type 1 expressed in xenopus oocytes or Aplysia neurons.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aplysia; Capsaicin; Cloning, Molecular; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Membrane Potentials; Neurons; Oocytes; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Receptors, Adrenergic, beta-2; Receptors, Drug; Signal Transduction; Transfection; TRPV Cation Channels; Xenopus | 2000 |
[Intracellular cAMP involvement in the synchronized activity of noradrenaline in response to evoked release of the transmitter quanta in the frog synapses].
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Colforsin; Cyclic AMP; Electric Stimulation; Electrophysiology; Enzyme Activation; Neuromuscular Junction; Neurotransmitter Agents; Norepinephrine; Phosphodiesterase Inhibitors; Rana ridibunda; Synapses | 2000 |
Effects of N(G)-monomethyl-L-arginine on Ca(2+) current and nitric-oxide synthase in rat ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Calcium Channels, L-Type; Colforsin; Cyclic GMP; Enzyme Inhibitors; Milrinone; NADPH Dehydrogenase; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Rats | 2000 |
Phosphodiesterase inhibitors and forskolin Up-regulate arginase activity in rabbit alveolar macrophages.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginase; Colforsin; Female; Isoenzymes; Lipopolysaccharides; Macrophages, Alveolar; Male; Ornithine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rabbits; Up-Regulation | 2000 |
Laminin acts via beta 1 integrin signalling to alter cholinergic regulation of L-type Ca(2+) current in cat atrial myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Actins; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Calcium Channels, L-Type; Cats; Cells, Cultured; Colforsin; Cyclic AMP; Cytoskeleton; Female; Heart Atria; Integrin beta1; Laminin; Male; Milrinone; Myocardium; Nitric Oxide Donors; Nitrogen Oxides; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Signal Transduction; Spermine; Thionucleotides | 2000 |
Activation of transepithelial ion transport by secretin in human intestinal Caco-2 cells.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Caco-2 Cells; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Intestinal Mucosa; Ion Transport; Nitrobenzoates; Phosphodiesterase Inhibitors; Secretin | 2000 |
Lidocaine potentiates the relaxant effects of cAMP-elevating agents in bovine tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Albuterol; Anesthetics, Local; Animals; Bupivacaine; Cattle; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; In Vitro Techniques; Lidocaine; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Procaine; Trachea | 2000 |
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulation; Glucagon; Glucose; Insulinoma; Islets of Langerhans; Kinetics; Membrane Proteins; Pancreatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Cyclic AMP-mediated inhibition of noradrenaline-induced contraction and Ca2+ influx in guinea-pig vas deferens.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Calcium Channel Blockers; Colforsin; Cyclic AMP; Guinea Pigs; Intracellular Membranes; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Osmolar Concentration; Potassium; Vas Deferens | 2000 |
Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Carbachol; Cell Membrane; Cells, Cultured; Chickens; Colforsin; Hemagglutination Tests; Influenza A virus; Intestinal Mucosa; Kidney Cortex; Kidney Tubules, Collecting; Mice; Respiratory Mucosa; Sodium Channels; Trachea; Virulence Factors, Bordetella | 2000 |
Cyclic AMP and LDL trigger a rapid enhancement in gap junction assembly through a stimulation of connexin trafficking.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brefeldin A; Cell Aggregation; Cell Membrane Permeability; Colforsin; Connexin 43; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Fluorescent Dyes; Gap Junctions; Ionophores; Lipoproteins, LDL; Microtubules; Monensin; Nocodazole; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Tumor Cells, Cultured | 2000 |
Identification of maturation-inducing steroid in a freshwater perch Anabas testudineus and differential responses of intact follicles and denuded oocytes to cyclic AMP in oocyte maturation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Dihydrotestosterone; Female; Hydroxyprogesterones; Oocytes; Organ Culture Techniques; Ovarian Follicle; Perches; Pregnenolone | 2000 |
Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Aged; Amiloride; Animals; Child; Child, Preschool; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Epithelium; Female; Gene Expression; Genistein; Humans; Ion Channels; Ion Transport; Membrane Potentials; Middle Aged; Mutation; Nasal Cavity; Oocytes; Rectum; Sodium Channels; Xenopus | 2000 |
Role of K(V)LQT1 in cyclic adenosine monophosphate-mediated Cl(-) secretion in human airway epithelia.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Biological Transport; Bronchi; Cell Line, Transformed; Chlorides; Chromans; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diuretics; Gene Expression; Humans; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Membrane Potentials; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Respiratory Mucosa; Sulfonamides | 2000 |
Divergent regulation of GAP-43 expression and CNS neurite outgrowth by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Axons; Bucladesine; Cell Line, Transformed; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; GAP-43 Protein; Gene Expression; Neurites; Neurons; Phenotype; Phosphodiesterase Inhibitors; Raphe Nuclei; Rats; Signal Transduction; Virulence Factors, Bordetella | 2000 |
A novel Na+-dependent transporter and NHE3 mediate H+ efflux in the luminal membrane of the pancreatic duct: regulation by cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Cell Membrane; Colforsin; Cyclic AMP; Guanidines; Mice; Mice, Knockout; Pancreatic Ducts; Phosphodiesterase Inhibitors; Protons; Quaternary Ammonium Compounds; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones | 2000 |
Synaptic plasticity in the human dentate gyrus.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Colforsin; Dentate Gyrus; Electric Stimulation; Electrodes, Implanted; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Memory Disorders; Middle Aged; Neuronal Plasticity; Perforant Pathway; Phosphodiesterase Inhibitors; Receptors, N-Methyl-D-Aspartate; Sclerosis; Synaptic Transmission | 2000 |
Activation of epithelial Na(+) channel activity in the rabbit urinary bladder by cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Epithelial Cells; Female; Male; Phosphodiesterase Inhibitors; Rabbits; Sodium Channels; Urinary Bladder | 2000 |
Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Substitution; Animals; Apoptosis; bcl-Associated Death Protein; Carrier Proteins; Cell Line; Cell Survival; CHO Cells; Colforsin; Cricetinae; Culture Media, Serum-Free; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Kidney; Phosphorylation; Phosphoserine; Proteins; Recombinant Fusion Proteins; Transfection | 2000 |
Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding Sites; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Diabetes Mellitus; DNA; DNA-Binding Proteins; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Insulin; Islets of Langerhans; Male; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Western; Cell Differentiation; Cell Survival; Cells, Cultured; Chromatography, Affinity; Chromones; Colforsin; Dose-Response Relationship, Drug; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Ganglia, Spinal; Immunohistochemistry; Luciferases; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Nerve Growth Factor; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-raf; rap1 GTP-Binding Proteins; ras Proteins; Rats; Receptor, trkA; Signal Transduction; Time Factors; Transfection | 2000 |
Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Caffeine; Calcium; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Gene Expression; Humans; Magnesium; Membrane Potentials; Nitroprusside; Patch-Clamp Techniques; Potassium Channels; Recombinant Proteins; Theophylline; Transfection; Xanthines | 2000 |
Dissociation of morphine-induced cyclic AMP-upregulation and mu-opioid receptor desensitization.
Topics: 1-Methyl-3-isobutylxanthine; Analgesics, Opioid; Cell Line; Colforsin; Cyclic AMP; Humans; Morphine; Phosphodiesterase Inhibitors; Receptors, Opioid, mu; Up-Regulation | 2000 |
Cyclic AMP-dependent and independent stimulations of ovarian steroidogenesis by brain factors in the blowfly, Phormia regina.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Age Factors; Animals; Brain Chemistry; Colforsin; Cyclic AMP; Dietary Proteins; Diptera; Ecdysteroids; Enzyme Inhibitors; Female; Insect Hormones; Ovary; Phosphodiesterase Inhibitors; Signal Transduction; Steroids; Thionucleotides | 2000 |
Establishment and characterization of steroidogenic granulosa cells expressing beta(2)-adrenergic receptor: regulation of adrenodoxin and steroidogenic acute regulatory protein by adrenergic agents.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Adrenodoxin; Animals; Blotting, Western; Cell Line, Transformed; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; Female; Follicle Stimulating Hormone; Genes, ras; Granulosa Cells; Immunohistochemistry; Isoproterenol; Metoprolol; Phosphodiesterase Inhibitors; Phosphoproteins; Plasmids; Progesterone; Propranolol; Rats; Receptors, Adrenergic, beta-2; Simian virus 40; Transfection | 2000 |
Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Caffeine; Calcium Channel Blockers; Chlorides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Iodides; Iodine Radioisotopes; Membrane Potentials; Membrane Proteins; ortho-Aminobenzoates; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphorylation; Respiratory Mucosa; Theophylline; Xanthines | 2000 |
Angiotensin II enhances beta-adrenergic receptor-mediated vasorelaxation in aortas from young but not old rats.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Aging; Angiotensin II; Animals; Aorta, Thoracic; Bucladesine; Colforsin; Cyclic AMP; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Phosphodiesterase Inhibitors; Pyridines; Rats; Rats, Inbred F344; Receptor Cross-Talk; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstrictor Agents; Vasodilation | 2000 |
Chloride channel expression in cultured human fetal RPE cells: response to oxidative stress.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amino Acid Sequence; Base Sequence; Blotting, Western; Cell Line, Transformed; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; DNA, Complementary; Fetus; Humans; Hydrogen Peroxide; Membrane Potentials; Molecular Sequence Data; Oxidative Stress; Patch-Clamp Techniques; Pigment Epithelium of Eye; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Parathyroid hormone-related protein down-regulates bone sialoprotein gene expression in cementoblasts: role of the protein kinase A pathway.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Dental Cementum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Integrin-Binding Sialoprotein; Kinetics; Parathyroid Hormone-Related Protein; Phorbol 12,13-Dibutyrate; Proteins; RNA, Messenger; Second Messenger Systems; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Thionucleotides | 2000 |
Parathyroid hormone potentiates nucleotide-induced [Ca2+]i release in rat osteoblasts independently of Gq activation or cyclic monophosphate accumulation. A mechanism for localizing systemic responses in bone.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Animals; Calcium; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Gene Expression; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Osteoblasts; Parathyroid Hormone; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Purinergic P2 Receptor Agonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1 | 2001 |
Preferential potentiation of fast-releasing synaptic vesicles by cAMP at the calyx of Held.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzothiadiazines; Brain Stem; Calcium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kinetics; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Presynaptic Terminals; Rats; Rats, Wistar; Synaptic Transmission; Synaptic Vesicles | 2001 |
Regulation of interphotoreceptor retinoid-binding protein (IRBP) gene expression by cAMP in differentiated retinoblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Blotting, Northern; Cell Differentiation; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Eye Proteins; Gene Expression Regulation; Humans; Laminin; Nuclease Protection Assays; Radioimmunoassay; Retinal Neoplasms; Retinoblastoma; Retinol-Binding Proteins; RNA, Messenger; Tumor Cells, Cultured | 2000 |
Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aspartic Acid Endopeptidases; Cell Line; Colforsin; Gene Expression Regulation; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Kinetics; Luciferases; Mice; Peptide Fragments; Proglucagon; Proprotein Convertase 1; Proprotein Convertases; Protein Precursors; Rats; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection | 2001 |
The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Guanylate Cyclase; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Purinones; Radioimmunoassay; Rats; Signal Transduction | 2001 |
Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylate Cyclase Toxin; Adipocytes; Adipose Tissue; Animals; Bucladesine; Cells, Cultured; Colforsin; Kinetics; Leptin; Lipolysis; Male; Obesity; Purinergic P1 Receptor Antagonists; Rats; Rats, Mutant Strains; Rats, Zucker; Recombinant Proteins; Signal Transduction; Virulence Factors, Bordetella | 2001 |
Proline transport in MDCK cells expressing a mutant regulatory subunit of cAMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Blotting, Northern; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Dogs; Drug Resistance; Genetic Vectors; Kidney Tubules; Metallothionein; Mice; Mutation; Neomycin; Phosphodiesterase Inhibitors; Proline; Protein Synthesis Inhibitors; Sodium Chloride; Time Factors; Transfection | 2001 |
Activation of 5-HT receptors that stimulate the adenylyl cyclase pathway positively regulates IGF-I in cultured craniofacial mesenchymal cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Insulin-Like Growth Factor I; Mandible; Mesoderm; Mice; Phosphodiesterase Inhibitors; Phosphorylation; Promoter Regions, Genetic; Receptors, Serotonin; Serotonin Receptor Agonists; Thionucleotides | 2001 |
Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Aorta; Aurora Kinases; Blood Pressure; Carotid Arteries; Colforsin; Coronary Vessels; Cyclic AMP; Cyclic GMP; GTP-Binding Proteins; Heart Failure; In Vitro Techniques; Isoproterenol; Ligation; Muscle, Smooth, Vascular; Myocardial Infarction; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Signal Transduction; Ventricular Pressure | 2001 |
Group III metabotropic glutamate receptors in rat cultured calvarial osteoblasts.
Topics: 1-Methyl-3-isobutylxanthine; Aminobutyrates; Animals; Animals, Newborn; Cells, Cultured; Colforsin; Cyclic AMP; Gene Expression; Glycine; Male; Osteoblasts; Protein Isoforms; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skull | 2001 |
Arachidonic acid release by ionomycin and phorbol ester is similar in C127 epithelial cells expressing wild-type or mutated (delta F508) cystic fibrosis transmembrane conductance regulator.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Calcium; Cell Line; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Immunoblotting; Ionomycin; Ionophores; Ions; Mice; Mutation; Phorbol Esters; Phospholipases A; Phospholipases A2; Spectrometry, Fluorescence; Time Factors; Transfection | 1999 |
Effect of cAMP on inducible nitric oxide synthase gene expression: its dual and cell-specific functions.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Bucladesine; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; DNA Primers; Enzyme Induction; Gene Expression; Interferon-gamma; Interleukin-1; Lipopolysaccharides; Mice; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Rats; RNA, Messenger | 2000 |
Cloning and function of the rat colonic epithelial K+ channel KVLQT1.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Barium; Carbachol; Cardiotonic Agents; Cloning, Molecular; Colforsin; Colon; Cyclic AMP; Dinoprostone; Humans; In Vitro Techniques; Intestinal Mucosa; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Male; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Tetraethylammonium; Xenopus laevis | 2001 |
Control of the cystic fibrosis transmembrane conductance regulator by alphaG(i) and RGS proteins.
Topics: 1-Methyl-3-isobutylxanthine; 14-3-3 Proteins; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Chloride Channels; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Female; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; Membrane Potentials; Oocytes; Repressor Proteins; RGS Proteins; RNA, Complementary; Time Factors; Tyrosine 3-Monooxygenase; Xenopus laevis | 2001 |
The human ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3): promoter characterization and genomic structure.
Topics: 1-Methyl-3-isobutylxanthine; Base Sequence; Cloning, Molecular; Colforsin; DNA; Exons; Genes; HeLa Cells; Humans; Introns; Luciferases; Phorbol Esters; Phosphofructokinase-2; Promoter Regions, Genetic; Proteins; Recombinant Fusion Proteins | 2001 |
Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel.
Topics: 1-Methyl-3-isobutylxanthine; Acids; Animals; Barium Compounds; Bupivacaine; Cell Line; Cesium; Chlorides; Colforsin; Dose-Response Relationship, Drug; Female; Gene Expression; Glyburide; Halothane; Humans; Kinetics; Membrane Potentials; Oocytes; Potassium; Potassium Channels; Potassium Channels, Tandem Pore Domain; Pregnanediones; Tetradecanoylphorbol Acetate; Tetraethylammonium; Time Factors; Xenopus | 2001 |
Studies of insulin secretory responses and of arachidonic acid incorporation into phospholipids of stably transfected insulinoma cells that overexpress group VIA phospholipase A2 (iPLA2beta ) indicate a signaling rather than a housekeeping role for iPLA2b
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Arachidonic Acid; Colforsin; Enzyme Inhibitors; Glucose; Group VI Phospholipases A2; Humans; Insulin; Insulin Secretion; Insulinoma; Kinetics; Mice; Naphthalenes; Pancreatic Neoplasms; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Pyrones; Rats; Recombinant Proteins; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Transfection; Tumor Cells, Cultured | 2001 |
Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Autocrine Communication; Calcium; Calcium Channels, L-Type; Cattle; Cells, Cultured; Chromaffin Cells; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; GABA Antagonists; Isoquinolines; Kinetics; Naloxone; Narcotic Antagonists; Patch-Clamp Techniques; Picrotoxin; Protein Kinase Inhibitors; Sulfonamides; Suramin | 2001 |
Nongenomic effect of testosterone on chloride secretion in cultured rat efferent duct epithelia.
Topics: 1-Methyl-3-isobutylxanthine; Acetazolamide; Aldosterone; Amiloride; Animals; Calcium Channel Blockers; Cell Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Dexamethasone; Dihydrotestosterone; Epithelial Cells; Ion Channels; Kinetics; Male; ortho-Aminobenzoates; Phlorhizin; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Testis; Testosterone | 2001 |
Effects of cyclic adenosine-monophosphate on growth and PSA secretion of human prostate cancer cell line.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cell Division; Colforsin; Cyclic AMP; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 2001 |
Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Apoptosis; Arginine; Astrocytes; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Energy Metabolism; Enzyme Activation; Gene Products, tat; GTP-Binding Protein alpha Subunits, Gi-Go; HIV-1; Hydrazines; Isoproterenol; Lipopolysaccharides; Microglia; Nerve Degeneration; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroso Compounds; Peptides; Pertussis Toxin; Rats; Rats, Wistar; Recombinant Fusion Proteins; Second Messenger Systems; tat Gene Products, Human Immunodeficiency Virus; Tosylphenylalanyl Chloromethyl Ketone; Virulence Factors, Bordetella | 2001 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Sonic hedgehog and FGF8: inadequate signals for the differentiation of a dopamine phenotype in mouse and human neurons in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cells, Cultured; Colforsin; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Fibroblast Growth Factor 8; Fibroblast Growth Factors; Hedgehog Proteins; Humans; MAP Kinase Signaling System; Mice; Neurons; Phenotype; Proteins; Signal Transduction; Tissue Plasminogen Activator; Trans-Activators; Tyrosine 3-Monooxygenase | 2001 |
Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Chemotactic Factors; Chemotaxis, Leukocyte; Chromones; Colforsin; Flavonoids; Humans; In Vitro Techniques; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Signal Transduction; Wortmannin | 2001 |
Functional consequences of the arrhythmogenic G306R KvLQT1 K+ channel mutant probed by viral gene transfer in cardiomyocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenoviridae; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; CHO Cells; Colforsin; Cricetinae; Gene Transfer Techniques; Green Fluorescent Proteins; Guinea Pigs; Heart Ventricles; Humans; In Vitro Techniques; Indapamide; Indicators and Reagents; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Kidney; Luminescent Proteins; Membrane Potentials; Mice; Muscle Fibers, Skeletal; Myocardium; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium Channels; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds | 2001 |
The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Animals; Calcium; Colforsin; Electric Conductivity; Gene Expression Regulation; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Potassium Channel Blockers; Potassium Channels; Quaternary Ammonium Compounds; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetraethylammonium; Tolbutamide; Tumor Cells, Cultured | 2001 |
ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amides; Arachidonic Acids; Cell Line; Cells, Cultured; Chloride Channels; Chlorides; CLC-2 Chloride Channels; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Ethyldimethylaminopropyl Carbodiimide; Humans; Magnesium; Mouth Mucosa; Omeprazole; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Recombinant Proteins; Respiratory Mucosa | 2001 |
Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Division; Cell Line; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; DNA Primers; Enzyme Activation; Humans; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Sphingosine | 2001 |
cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Apoptosis; bcl-X Protein; Caspases; CDC2-CDC28 Kinases; Cell Adhesion; Cell Cycle; Cell Survival; Colforsin; Culture Media; Cyclic AMP; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Gene Expression Regulation, Neoplastic; Histones; Humans; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma Protein; Tumor Cells, Cultured | 2001 |
Prostaglandins and nitric oxide mediate superoxide-induced myocardial contractile dysfunction in isolated rat hearts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aspartate Aminotransferases; Colforsin; Enzyme Inhibitors; Heart; Myocardial Contraction; Myocardium; Nitrates; Nitric Acid; Nitroarginine; Nitroglycerin; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Prostaglandins; Quinoxalines; Rats; Superoxides; Thromboxane A2; Vasodilator Agents | 2001 |
Biphasic response to human galanin of extracellular acidification in human Bowes melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Acids; Amiloride; Cell Line; Colforsin; Dose-Response Relationship, Drug; Extracellular Space; Galanin; Gene Expression; Humans; Hydrogen-Ion Concentration; Melanoma; Peptide Fragments; Pertussis Toxin; Receptors, Galanin; Receptors, Neuropeptide; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Effect of somatostatin on cholecystokinin-induced amylase release in rat pancreatic acini.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Amylases; Animals; Calcium Signaling; Cell-Free System; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Inositol Phosphates; MAP Kinase Signaling System; Octreotide; Pancreas; Protein Tyrosine Phosphatases; Rats; Second Messenger Systems; Secretory Rate; Sincalide; Sodium Fluoride; Somatostatin; Tungsten Compounds | 2001 |
Platelet-derived growth factor stimulates phospholipase C-gamma 1, extracellular signal-regulated kinase, and arachidonic acid release in rat myometrial cells: contribution to cyclic 3',5'-adenosine monophosphate production and effect on cell proliferatio
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Becaplermin; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Cyclooxygenase Inhibitors; Drug Synergism; Enzyme Activation; Epoprostenol; Female; GTP-Binding Protein alpha Subunits, Gs; Indomethacin; Inositol Phosphates; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myometrium; Phospholipases A; Phosphotyrosine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Wistar; Type C Phospholipases | 2001 |
Therapeutic differentiation of tumor-derived insulin-producing cells selected for resistance to diabetogenic drugs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Drug Resistance; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Pancreatic Neoplasms; Rats; Streptozocin; Tumor Cells, Cultured | 2000 |
Structure-activity and possible mode of action of S-Iamide neuropeptides on identified central neurons of Helix aspersa.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Amides; Amino Acid Sequence; Animals; Chlorides; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Helix, Snails; Neurons; Neuropeptides; Phosphodiesterase Inhibitors; Potassium; Second Messenger Systems; Structure-Activity Relationship | 2001 |
Parathyroid hormone receptor internalization is independent of protein kinase A and phospholipase C activation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding Sites; Cell Line; Cell Membrane; Coated Pits, Cell-Membrane; Colforsin; COS Cells; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Enzyme Activation; Gene Expression; Green Fluorescent Proteins; Kinetics; Luminescent Proteins; Mutagenesis; Parathyroid Hormone; Phosphorylation; Protein Kinase C; Rats; Receptors, Parathyroid Hormone; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases | 2001 |
In contrast to forskolin and 3-isobutyl-1-methylxanthine, amrinone stimulates the cardiac voltage-sensitive release mechanism without increasing calcium-induced calcium release.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Colforsin; Cyclic AMP; Electrophysiology; Enzyme Activators; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Sarcoplasmic Reticulum; Stimulation, Chemical | 2001 |
Characterisation of the rat SK4/IK1 K(+) channel.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Benzimidazoles; Calcium; Calmodulin; Charybdotoxin; Colforsin; Colon; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Intermediate-Conductance Calcium-Activated Potassium Channels; Intestinal Mucosa; Ionomycin; Oocytes; Patch-Clamp Techniques; Phosphorylation; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Kinase C; Rats; Recombinant Proteins; Sulfonamides; Xenopus laevis | 2001 |
Differentiation of human dopamine neurons from an embryonic carcinomal stem cell line.
Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dihydroxyphenylacetic Acid; Cell Differentiation; Colforsin; Culture Techniques; Dopamine; Fibroblast Growth Factor 1; Humans; Immunohistochemistry; Models, Biological; Neoplastic Stem Cells; Neurons; Parkinson Disease; Phosphodiesterase Inhibitors; Tissue Plasminogen Activator; Tyrosine 3-Monooxygenase | 2001 |
Activation of a CFTR-mediated chloride current in a rabbit corneal epithelial cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Chlorides; Colforsin; Cornea; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Gene Expression; Genistein; Glyburide; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2001 |
Regulation of slowly activating potassium current (I(Ks)) by secretin in rat pancreatic acinar cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Calcium Signaling; Carbachol; Chlorides; Cholinergic Agonists; Colforsin; Cyclic AMP; Enzyme Inhibitors; Gastrointestinal Agents; Isoproterenol; Isoquinolines; Membrane Potentials; Pancreas; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium Channels; Rats; Secretin; Sulfonamides; Vasoactive Intestinal Peptide | 2001 |
Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation to ATP release.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Dogs; Enzyme Inhibitors; Erythrocyte Deformability; Humans; Male; Nitric Oxide; Phosphodiesterase Inhibitors; Pulmonary Circulation; Rabbits; Signal Transduction; Thionucleotides | 2001 |
cGMP-mediated inhibition of cardiac L-type Ca(2+) current by a monoclonal antibody against the M(2) ACh receptor.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Antibodies, Monoclonal; Autoantibodies; Calcium Channels, L-Type; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanosine; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Fibers, Skeletal; Myocardium; Oxadiazoles; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Quinoxalines; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |
Assessment of chloride secretion in human nasal epithelial cells by X-ray microanalysis.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Chlorides; Colforsin; Cystic Fibrosis; Electron Probe Microanalysis; Epithelial Cells; Humans; Ion Transport; Nasal Mucosa | 2001 |
Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cantharidin; Cardiotonic Agents; Cell Cycle Proteins; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Ethanolamines; Gene Expression; Heart Failure; Isoproterenol; Luciferases; Myocardium; Phosphoprotein Phosphatases; Phosphorylation; Plant Proteins; Propane; Stimulation, Chemical; Time Factors; Transcription, Genetic | 2001 |
Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Transport System X-AG; Animals; Carcinogens; Carrier Proteins; Cell Membrane; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Indoles; Maleimides; Membrane Potentials; Oocytes; Phorbols; Protein Kinase C; RNA, Complementary; Symporters; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured; Xenopus laevis | 2001 |
cAMP is involved in the differentiation of human teratocarcinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Cell Culture Techniques; Cell Differentiation; Cell Size; Coculture Techniques; Colforsin; Cyclic AMP; Embryonal Carcinoma Stem Cells; Humans; Insulin; Myelin Sheath; Neoplastic Stem Cells; Neuregulin-1; Neurites; Neurons; Phosphodiesterase Inhibitors; Tretinoin | 2001 |
Bcl-2 protects lymphoma cells from apoptosis but not growth arrest promoted by cAMP and dexamethasone.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Annexin A5; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Cell Count; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Gene Expression Regulation; Genes, bcl-1; Humans; Isoproterenol; Lymphoma; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2001 |
BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Colforsin; Coturnix; Cyclic AMP; Gene Expression Regulation, Enzymologic; Melanins; Melanocytes; Mice; Monophenol Monooxygenase; Neural Crest; Phosphodiesterase Inhibitors; Pigmentation; Signal Transduction; Transforming Growth Factor beta | 2001 |
Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression.
Topics: 1-Methyl-3-isobutylxanthine; Alternative Splicing; Animals; Bucladesine; Cell Line; Colforsin; Gene Expression Regulation; Humans; Protein Isoforms; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Skin; Tetradecanoylphorbol Acetate; Tissue Distribution; Tumor Cells, Cultured; Ultraviolet Rays | 2001 |
Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Androstadienes; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Humans; Insulin; Isoproterenol; Lipolysis; Phosphodiesterase Inhibitors; Phosphorylation; Potassium Chloride; Quinolones; Sterol Esterase; Wortmannin; Xanthines | 2001 |
The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Butadienes; CCAAT-Enhancer-Binding Proteins; Cell Fractionation; Cell Line; Colforsin; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA; Enzyme Induction; Enzyme Inhibitors; Imidazoles; Isoenzymes; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Models, Biological; NF-kappa B; Nitriles; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; RNA, Messenger; Transcription Factors | 2001 |
Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Adenylyl Cyclases; Butyrates; Calcium; Cell Line; Chlorides; Cholera Toxin; Colforsin; Cyclic AMP; Dinoprostone; Humans; Intestinal Mucosa; Phosphodiesterase Inhibitors; Propionates; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Time Factors | 2001 |
Differential regulation of T cell receptor-mediated Th1 cell IFN-gamma production and proliferation by divergent cAMP-mediated redox pathways.
Topics: 1-Methyl-3-isobutylxanthine; Animals; CD3 Complex; CD4 Antigens; Cells, Cultured; Clone Cells; Colforsin; Cyclic AMP; Female; Interferon-gamma; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Phosphodiesterase Inhibitors; Receptors, Antigen, T-Cell; Signal Transduction; Th1 Cells | 2001 |
Identification of signal transduction pathways and promoter sequences that mediate parathyroid hormone 1-38 inhibition of osteoprotegerin gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcimycin; Colforsin; Gene Expression; Glycoproteins; Osteoblasts; Osteoprotegerin; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Peptide Fragments; Promoter Regions, Genetic; Proteins; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Thapsigargin | 2001 |
Presynaptic H3 autoreceptors modulate histamine synthesis through cAMP pathway.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Bucladesine; Colforsin; Cyclic AMP; Drug Interactions; Histamine; Imidazoles; In Vitro Techniques; Male; Piperidines; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Thionucleotides; Thiourea | 2002 |
Genistein restores functional interactions between Delta F508-CFTR and ENaC in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Sodium Channels; Female; Genistein; Humans; Oocytes; Recombinant Proteins; Sodium Channels; Xenopus laevis | 2002 |
Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta.
Topics: 1-Methyl-3-isobutylxanthine; Autocrine Communication; Blotting, Northern; Blotting, Western; Camphanes; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Dronabinol; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; GTP-Binding Proteins; Humans; Immunoenzyme Techniques; Lymphocytes; Models, Biological; Paracrine Communication; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; RNA; Transforming Growth Factor beta; Up-Regulation; Virulence Factors, Bordetella | 2002 |
Cyclic AMP raises intracellular Ca(2+) in human megakaryocytes independent of protein kinase A.
Topics: 1-Methyl-3-isobutylxanthine; Calcium; Calcium Channels; Cell Line; Chelating Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Humans; Iloprost; Inositol 1,4,5-Trisphosphate Receptors; Megakaryocytes; Phosphodiesterase Inhibitors; Phosphorylation; rap1 GTP-Binding Proteins; Receptors, Cytoplasmic and Nuclear; Vasodilator Agents | 2002 |
PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; B-Lymphocytes; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Spleen; Theophylline; Tumor Cells, Cultured; Up-Regulation; Xanthines | 2002 |
Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Colforsin; Cyclic AMP; Diazoxide; Glucagon; Glucagon-Like Peptide 1; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Phosphodiesterase Inhibitors; Potassium Channels; Protein Precursors; Rats; Rats, Wistar; Signal Transduction; Sodium Azide; Vasodilator Agents | 2002 |
Protein kinase A cascade regulates quantal release dispersion at frog muscle endplate.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Animals; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electric Conductivity; Enzyme Inhibitors; Motor Endplate; Muscle, Skeletal; Norepinephrine; Phosphodiesterase Inhibitors; Pressure; Rana ridibunda; Reaction Time; Synapses | 2002 |
Increase of cAMP upon release from prophase arrest in surf clam oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Animals; Bivalvia; Colforsin; Cyclic AMP; Cytoplasmic Vesicles; Drug Interactions; Enzyme Inhibitors; Female; Fertilization; Meiosis; Oocytes; Potassium Chloride; Prophase; Serotonin; Up-Regulation | 2002 |
Stimulation of chloride secretion by baicalein in isolated rat distal colon.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Atropine; Calcium; Carbachol; Chlorides; Colforsin; Colon; Cyclic AMP; Dinoprostone; Electric Conductivity; Female; Flavanones; Flavonoids; Indomethacin; Intestinal Mucosa; Male; Muscarinic Antagonists; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Thapsigargin | 2002 |
Circadian change of adenylate cyclase activity in rabbit ciliary processes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Ciliary Body; Circadian Rhythm; Colforsin; Cyclic AMP; Dark Adaptation; Intraocular Pressure; Light; Male; Phosphodiesterase Inhibitors; Rabbits; Receptors, Adrenergic, beta; Sympathectomy; Sympathetic Nervous System | 2001 |
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; A Kinase Anchor Proteins; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Fluorescence; Green Fluorescent Proteins; Intracellular Membranes; Kinetics; Luminescent Proteins; Minor Histocompatibility Antigens; Myocardium; Norepinephrine; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins; Rats; Receptors, Adrenergic, beta; Recombinant Fusion Proteins; Sarcoplasmic Reticulum; Second Messenger Systems; Transfection | 2002 |
Glucocorticoid-stimulated lung epithelial Na(+) transport is associated with regulated ENaC and sgk1 expression.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Cell Line; Colforsin; Cyclic AMP; Dexamethasone; Diuretics; Epithelial Cells; Epithelial Sodium Channels; Extravascular Lung Water; Gene Expression Regulation; Glucocorticoids; Humans; Immediate-Early Proteins; Nuclear Proteins; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Protein Subunits; Pulmonary Alveoli; Respiratory Mucosa; RNA, Messenger; Sodium; Sodium Channels | 2002 |
Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Nucleus; Colforsin; Cyclic AMP-Dependent Protein Kinases; Fluorescent Antibody Technique; Gene Expression; Glucose; Glycosylation; Group VI Phospholipases A2; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Phospholipases A; Phosphorylation; Rats; Signal Transduction; Transfection; Tumor Cells, Cultured | 2002 |
Involvement of cAMP but not PKA in the increase of corticosterone secretion in rat zona fasciculata-reticularis cells by aging.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Adrenocorticotropic Hormone; Aging; Animals; Carrier Proteins; Colforsin; Corticosterone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Desoxycorticosterone; Female; Intracellular Signaling Peptides and Proteins; Isoquinolines; Ovariectomy; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Prolactin; Rats; Rats, Sprague-Dawley; Sulfonamides; Zona Fasciculata; Zona Reticularis | 2002 |
Gonadotropin regulation of activin betaA and activin type IIA receptor expression in the ovarian follicle cells of the zebrafish, Danio rerio.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Activin Receptors, Type II; Animals; Colforsin; DNA Primers; Female; Gonadotropins; Inhibin-beta Subunits; Male; Oocytes; Ovarian Follicle; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theca Cells; Zebrafish | 2002 |
Intracellular cysteines of the cystic fibrosis transmembrane conductance regulator (CFTR) modulate channel gating.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Chlorides; Colforsin; Cysteine; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expression; Humans; In Vitro Techniques; Ion Channel Gating; Kidney; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Structure-Activity Relationship; Sulfhydryl Reagents; Transfection; Xenopus laevis | 2002 |
Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aorta; Cell Membrane; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytosol; Diabetes Mellitus, Type 2; Hydrolysis; Muscle, Smooth, Vascular; Obesity; Phenotype; Phosphodiesterase Inhibitors; Quinolones; Rats; Rats, Mutant Strains | 2002 |
Roles of cAMP in regulation of both MAP kinase and p34(cdc2) kinase activity during meiotic progression, especially beyond the MI stage.
Topics: 1-Methyl-3-isobutylxanthine; Animals; CDC2 Protein Kinase; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Chromones; Colforsin; Cyclic AMP; Female; Meiosis; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Oocytes; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Swine; Time Factors | 2002 |
Protein kinase-dependent and Ca(2+)-independent cAMP inhibition of ANP release in beating rabbit atria.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Atrial Function; Atrial Natriuretic Factor; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Indoles; Myocardial Contraction; Myocardium; Nifedipine; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Rabbits; Staurosporine | 2002 |
cAMP modulation of Ca(2+)-regulated exocytosis in ACh-stimulated antral mucous cells of guinea pig.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Calcium; Colforsin; Cyclic AMP; Dinitrophenols; Drug Synergism; Exocytosis; Gastric Mucins; Gastric Mucosa; Guinea Pigs; Hypoxia; Isoproterenol; Male; Microscopy, Video; Phosphodiesterase Inhibitors; Pyloric Antrum; Uncoupling Agents | 2002 |
Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Benzophenanthridines; Ciliary Body; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; In Vitro Techniques; Iris; Naltrexone; Narcotic Antagonists; Phenanthridines; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperidines; Protein Kinase C; Pyrrolidines; Rabbits; Receptors, Opioid, kappa; Rolipram | 2002 |
ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Alternative Splicing; Animals; Calcimycin; Carrier Proteins; Cell Line; Chloride Channels; CHO Cells; Colforsin; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expression; Humans; Ionophores; Membrane Potentials; Membrane Proteins; Mice; Phosphoproteins; Protein Binding; Protein Isoforms; Sodium-Hydrogen Exchangers; Transfection | 2002 |
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Colforsin; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Genes, Reporter; Mice; Mitogen-Activated Protein Kinases; Peptide Mapping; Phosphodiesterase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-raf; Serine; Signal Transduction; Tetradecanoylphorbol Acetate | 2002 |
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bronchoalveolar Lavage; Cells, Cultured; Chemokine CXCL2; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Female; Fluorescent Antibody Technique; Genetic Complementation Test; Humans; Lung; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monokines; Mutation; Phosphodiesterase Inhibitors; Pseudomonas aeruginosa; Pseudomonas Infections; RNA, Messenger; Tumor Necrosis Factor-alpha | 2002 |
Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Cell Division; Colforsin; COS Cells; Cyclic AMP; Mice; Models, Biological; Mutagenesis, Site-Directed; Phosphorylation; Proto-Oncogene Proteins c-raf; Signal Transduction | 2002 |
Changes in cardiac myocyte morphology alter the properties of voltage-gated ion channels.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Animals, Newborn; Calcium Channels, L-Type; Cell Culture Techniques; Cell Size; Colforsin; Cyclic AMP-Dependent Protein Kinases; Ion Channel Gating; Ion Channels; Myocardium; Patch-Clamp Techniques; Potassium Channels; Rats; Signal Transduction; Sodium Channels | 2002 |
Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antipsychotic Agents; Aripiprazole; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; GTP-Binding Proteins; Humans; Piperazines; Quinolones; Radioligand Assay; Receptors, Dopamine D2; Signal Transduction; Spiperone | 2002 |
The estrogen-occupied estrogen receptor functions as a negative regulator to inhibit cell proliferation induced by insulin/IGF-1: a cell context-specific antimitogenic action of estradiol on rat lactotrophs in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antimetabolites; Bromodeoxyuridine; Cell Division; Cells, Cultured; Colforsin; Cyclin D1; Estradiol; Estrogen Antagonists; Female; Immunohistochemistry; Indicators and Reagents; Insulin; Insulin-Like Growth Factor I; Mitogens; Pituitary Gland, Anterior; Rats; Rats, Wistar; Receptors, Estrogen | 2002 |
Regulation of vasodilator-stimulated phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Epithelial Cells; Extracellular Matrix; Fibroblasts; Humans; Mice; Microfilament Proteins; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-abl | 2002 |
Cyclic AMP stimulates renin gene transcription in juxtaglomerular cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enhancer Elements, Genetic; Juxtaglomerular Apparatus; Mice; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Phosphorylation; Promoter Regions, Genetic; Rats; Renin; RNA, Messenger; Transcriptional Activation | 2002 |
The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Bucladesine; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Indoles; Kidney Cortex; Kidney Medulla; Male; Okadaic Acid; Phosphodiesterase Inhibitors; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 2002 |
Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Activation; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Humans; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Phenethylamines; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Potassium Channels; Potassium Channels, Voltage-Gated; RNA, Complementary; Sulfonamides; Trans-Activators; Transcriptional Regulator ERG; Xenopus laevis | 2002 |
Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Melatonin; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Probenecid; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Tryptamines; Tumor Cells, Cultured | 2002 |
Postnatal handling induces long-term modifications in central beta-noradrenergic signalling in rats.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Aging; Animals; Animals, Newborn; Cerebellum; Cerebral Cortex; Colforsin; Cyclic AMP; Female; Handling, Psychological; Hippocampus; Isoproterenol; Norepinephrine; Phosphodiesterase Inhibitors; Pregnancy; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Signal Transduction | 2002 |
S-Nitrosoglutathione induces functional DeltaF508-CFTR in airway epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Cell Line; Cell Membrane; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Fluorescent Dyes; Mutagenesis; Nigericin; Nitric Oxide Donors; Recombinant Proteins; Respiratory Mucosa; S-Nitrosoglutathione; Sequence Deletion | 2002 |
Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Lipolysis; Male; Peptide Fragments; Phosphofructokinase-2; Protein Precursors; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2003 |
Heterologous sensitization of adenylate cyclase is protein kinase A-dependent in Cath.a differentiated (CAD)-D2L cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine Agonists; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Isoenzymes; Mice; Neurons; Phosphodiesterase Inhibitors; Quinpirole; Receptors, Dopamine D2; RNA, Messenger | 2002 |
Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; beta-Adrenergic Receptor Kinases; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 3; Gene Expression; Genes, Immediate-Early; Interleukin-6; Isoproterenol; Mice; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; Receptors, Parathyroid Hormone; RNA, Messenger; Sympathomimetics; Tumor Cells, Cultured | 2002 |
cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression.
Topics: 1-Methyl-3-isobutylxanthine; CD28 Antigens; Cell Cycle; Colforsin; Cyclic AMP; Cytokines; Humans; Lymphocyte Activation; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; rap1 GTP-Binding Proteins; ras Proteins; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes | 2003 |
Xanthine derivatives without PDE effect stimulate voltage-activated chloride conductance of toad skin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bufonidae; Cell Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Epithelial Cells; Furosemide; Membrane Potentials; Skin; Xanthines | 2003 |
Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Calcium; Cerulenin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Membrane Potentials; Peptide Fragments; Potassium; Protein Precursors; Rats; Rats, Wistar | 2002 |
Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: membrane versus nuclear receptor activation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Membrane; Colforsin; Cyclic AMP; Dihydrotestosterone; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Kinetics; Neurons; Pertussis Toxin; Receptors, Androgen; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Transfection | 2002 |
Inhibition of cyclooxygenase-2: effects on renin secretion and expression in fetal lambs.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Blood Gas Analysis; Cells, Cultured; Colforsin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Female; Gene Expression Regulation, Developmental; Heart Rate; Isoenzymes; Isoproterenol; Kidney Cortex; Nitrobenzenes; Phosphodiesterase Inhibitors; Pregnancy; Prostaglandin-Endoperoxide Synthases; Renin; Renin-Angiotensin System; RNA, Messenger; Sheep, Domestic; Sulfonamides | 2003 |
Regulation of growth hormone release in common carp pituitary cells by pituitary adenylate cyclase-activating polypeptide: signal transduction involves cAMP- and calcium-dependent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Carps; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Growth Hormone; Imines; In Vitro Techniques; Ionophores; Isoquinolines; Neuropeptides; Neurotransmitter Agents; Nifedipine; Phosphodiesterase Inhibitors; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland; Signal Transduction; Sulfonamides; Vasoactive Intestinal Peptide | 2002 |
Forskolin-induced clearance of the fluorescent dye sulforhodamine from rat parotid intralobular duct lumen: visualization of the secretory function under a confocal laser scanning microscope.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bicarbonates; Colforsin; Fluorescent Dyes; In Vitro Techniques; Male; Metabolic Clearance Rate; Microscopy, Confocal; Parotid Gland; Rats; Rats, Wistar; Rhodamines | 2002 |
Involvement of cyclic adenosine 3',5'-monophosphate in the differential regulation of activin betaA and betaB expression by gonadotropin in the zebrafish ovarian follicle cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Bucladesine; Cells, Cultured; Cloning, Molecular; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Female; Gene Expression; Gonadotropins; Humans; Inhibin-beta Subunits; Molecular Sequence Data; Ovarian Follicle; Phosphodiesterase Inhibitors; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Zebrafish | 2003 |
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin | 2003 |
Adenylyl cyclase expression and modulation of cAMP in rat taste cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Epithelium; Glutamic Acid; Isoenzymes; Male; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Taste; Taste Buds; Transducin | 2003 |
Cyclic adenosine 3',5'-monophosphate regulation of corticotropin-releasing hormone promoter activity in AtT-20 cells and in a transformed hypothalamic cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Cell Line, Transformed; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Hypothalamus; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pituitary Gland; Promoter Regions, Genetic; Rats; Vasopressins | 2003 |
Effects of purinergic stimulation, CFTR and osmotic stress on amiloride-sensitive Na+ transport in epithelia and Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Female; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Ion Channel Gating; Ion Transport; Mannitol; Membrane Potentials; Mice; Oocytes; Osmotic Pressure; Purines; Receptors, Purinergic; Respiratory Mucosa; Sodium; Sodium Chloride; Trachea; Uridine Triphosphate; Xenopus laevis | 2003 |
Inhibition of ovarian steroidogenesis by cyclic GMP in a fly.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Alkaloids; Animals; Brain; Calcium Channels; Carbazoles; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diptera; Ecdysteroids; Female; Indoles; Organ Culture Techniques; Ovary; Phosphodiesterase Inhibitors; Quinazolines; Signal Transduction; Stimulation, Chemical | 2003 |
Fat accumulation in the rat during early pregnancy is modulated by enhanced insulin responsiveness.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Animals; Blood Glucose; Colforsin; Ethanolamines; Fatty Acids, Nonesterified; Female; Gestational Age; Glucose Tolerance Test; Glycerol; Insulin; Isoproterenol; Leptin; Lipids; Lipolysis; Lumbosacral Region; Organ Size; Pregnancy; Rats; Rats, Wistar; Receptors, Adrenergic, beta-3 | 2003 |
Potentiation of proopiomelanocortin gene expression in cultured pituitary cells by benzodiazepines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Anxiety Agents; Cells, Cultured; Colforsin; Diazepam; Gene Expression Regulation; Genes, Reporter; Kinetics; Luciferases; Mice; Midazolam; Pro-Opiomelanocortin; Transfection | 2003 |
Culture of human adipose tissue explants leads to profound alteration of adipocyte gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Adipocytes; Adipose Tissue; Adult; Carrier Proteins; Colforsin; Culture Media; Culture Techniques; DNA-Binding Proteins; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Gene Expression; Glucose Transporter Type 1; Glycolysis; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Lipolysis; Lipoprotein Lipase; Middle Aged; Monosaccharide Transport Proteins; Neoplasm Proteins; Nuclear Proteins; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sterol Esterase; Transcription Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins | 2003 |
In vitro pharmacological properties of two novel non-imidazole H3 receptor (H3R) antagonists.
Topics: 1-Methyl-3-isobutylxanthine; Binding, Competitive; Colforsin; Cyclic AMP; Histamine Agonists; Histamine Antagonists; Humans; Ligands; Methylhistamines; Phosphodiesterase Inhibitors; Piperazines; Receptors, Histamine H3 | 2003 |
Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Growth Factors; Endothelium, Vascular; Fibroblast Growth Factor 2; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Lymphokines; Microcirculation; Neovascularization, Physiologic; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Receptors, CXCR4; Sp1 Transcription Factor; Transcriptional Activation; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alanine; Amino Acid Sequence; Animals; Cloning, Molecular; Colforsin; COS Cells; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Glutathione Transferase; Humans; Immunoblotting; Inhibitory Concentration 50; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Mutation; Open Reading Frames; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proteins; Rats; Recombinant Fusion Proteins; Rolipram; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Time Factors; Two-Hybrid System Techniques | 2003 |
In situ Ca2+ imaging of odor responses in a coronal olfactory epithelium slice.
Topics: 1-Methyl-3-isobutylxanthine; Anesthetics, Local; Animals; Animals, Newborn; Benzyl Alcohol; Calcium; Colforsin; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Fura-2; Heptanol; In Vitro Techniques; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Odorants; Olfactory Mucosa; Olfactory Receptor Neurons; Phosphodiesterase Inhibitors; Potassium; Stimulation, Chemical | 2003 |
Differential effects of cyclic AMP on induction of nitric oxide synthase in 3T3-L1 cells and brown adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Adipose Tissue, Brown; Animals; Antineoplastic Agents; Bucladesine; Colforsin; Cyclic AMP; Enzyme Induction; Enzyme Inhibitors; I-kappa B Proteins; Interferon-gamma; Lipopolysaccharides; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphodiesterase Inhibitors; Rats; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2003 |
Cyclic AMP increases endogenous granulocyte colony-stimulating factor formation in monocytes and THP-1 macrophages despite attenuated TNF-alpha formation.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Bucladesine; Cell Line; Colforsin; Cyclic AMP; Dinoprostone; Female; Granulocyte Colony-Stimulating Factor; Humans; In Vitro Techniques; Lipopolysaccharides; Macrophages; Monocytes; Naphthyridines; Pentoxifylline; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Tumor Necrosis Factor-alpha; Up-Regulation | 2003 |
The cAMP pathway sensitizes VR1 expressed in oocytes from Xenopus laevis and in CHO cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Signaling; Capsaicin; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Enzyme Activation; Ion Channels; Oocytes; Patch-Clamp Techniques; Protein Kinase C; Rats; Receptors, Drug; Thionucleotides; TRPV Cation Channels; Xenopus laevis | 2003 |
Characterization of an organic anion transport system in a placental cell line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Biological Transport; Cell Line; Cell Membrane; Colforsin; Cyclic AMP; Dehydroepiandrosterone Sulfate; Enzyme Activation; Estradiol; Estrone; Female; Hydrogen-Ion Concentration; Kinetics; Lithium; Organic Anion Transporters; Placenta; Pregnancy; Rats; Sodium; Temperature; Tritium | 2003 |
Corticotropin-releasing factor (CRF) and related peptides confer neuroprotection via type 1 CRF receptors.
Topics: 1-Methyl-3-isobutylxanthine; Amphibian Proteins; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Cerebellum; Cerebral Cortex; Chromatin; Chromones; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glycogen Synthase Kinase 3; Hippocampus; In Situ Nick-End Labeling; Inhibitory Concentration 50; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neurons; Neuroprotective Agents; Peptide Fragments; Peptide Hormones; Peptides; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Thionucleotides; Time Factors; Urocortins; Urotensins; Vasodilator Agents | 2003 |
Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenylyl Cyclases; Amphotericin B; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Epinephrine; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Mice, Knockout; Patch-Clamp Techniques; Receptors, Adrenergic, alpha-2; Signal Transduction | 2003 |
Contribution of dopamine D2 receptors for the cAMP levels at the carotid body.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carotid Body; Colforsin; Cyclic AMP; Domperidone; Dopamine; Female; Hyperoxia; In Vitro Techniques; Male; Pentobarbital; Rats; Rats, Wistar; Receptors, Dopamine D2 | 2003 |
Relative and combined effects of estradiol and prolactin on corticosterone secretion in ovariectomized rats.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Colforsin; Corticosterone; Cyclic AMP; Drug Synergism; Estradiol; Female; Injections, Intravenous; Nifedipine; Ovariectomy; Phosphodiesterase Inhibitors; Prolactin; Rats; Rats, Sprague-Dawley; Signal Transduction | 2003 |
Impaired regulatory volume decrease in freshly isolated cholangiocytes from cystic fibrosis mice: implications for cystic fibrosis transmembrane conductance regulator effect on potassium conductance.
Topics: 1-Methyl-3-isobutylxanthine; Angiogenesis Inhibitors; Animals; Bile Ducts; Buffers; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; HEPES; Immunohistochemistry; Ionophores; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Microscopy, Video; Nitrobenzoates; Potassium; Sodium Chloride; Time Factors; Valinomycin | 2004 |
Protease inhibitors prevent the protein kinase A-dependent loss of Rap1 GTPase from the particulate fraction of COS1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies; Cell Fractionation; Colforsin; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Enzyme Activation; Gene Expression; PC12 Cells; Protease Inhibitors; rap1 GTP-Binding Proteins; Rats; Transfection | 2004 |
Pharmacological properties of glycine transport in the frog retina.
Topics: 1-Methyl-3-isobutylxanthine; Amoxapine; Animals; Biological Transport; Colforsin; Glycine; Ranidae; Retina; Sarcosine; Tetradecanoylphorbol Acetate | 2004 |
The involvement of cyclic adenosine monophosphate in the control of schistosome miracidium cilia.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cilia; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Fresh Water; Movement; Osmolar Concentration; Phosphodiesterase Inhibitors; Saline Solution, Hypertonic; Schistosoma | 2004 |
Regulatory effects of interleukin-1beta and prostaglandin E2 on expression of receptor activator of nuclear factor-kappaB ligand in human periodontal ligament cells.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Bucladesine; Carrier Proteins; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Interleukin-1; Ligands; Male; Membrane Glycoproteins; NF-kappa B; Osteoclasts; Periodontal Ligament; Phosphodiesterase Inhibitors; Protein Kinase C; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger | 2004 |
PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Actins; Animals; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Line; Cell Movement; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Embryo, Mammalian; Enzyme Activation; Fibroblasts; Integrins; Intracellular Signaling Peptides and Proteins; Laminin; Myosin-Light-Chain Kinase; Neuropeptides; Protein Serine-Threonine Kinases; Pseudopodia; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Rolipram | 2004 |
Cyclic adenosine monophosphate (cAMP) increases natriuretic peptide receptor C (NPR-C) expression in human aortic smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Aorta; Atrial Natriuretic Factor; Bucladesine; Carbazoles; Cell Culture Techniques; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Guanylate Cyclase; Humans; Indoles; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Binding; Pyrroles; Receptors, Atrial Natriuretic Factor; RNA, Messenger; Signal Transduction | 2004 |
"Low" concentrations of sodium fluoride inhibit neurotransmitter release from the guinea-pig superior cervical ganglion.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Calcium; Colforsin; Cyclic AMP; Depression, Chemical; Electric Stimulation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Imidazoles; Imines; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Sodium Fluoride; Superior Cervical Ganglion | 2004 |
Altered activities of cyclic nucleotide phosphodiesterases and soluble guanylyl cyclase in cultured RFL-6 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Culture Techniques; Cell Line; Colforsin; Cyclic AMP; Fibroblasts; Gene Expression; Guanylate Cyclase; Lung; Nitric Oxide; Peptides, Cyclic; Phosphoric Diester Hydrolases; Rats; Receptors, Cell Surface; Rolipram; Solubility | 2004 |
cAMP-stimulated Na+ transport in H441 distal lung epithelial cells: role of PKA, phosphatidylinositol 3-kinase, and sgk1.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport; Cell Line; Chromones; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Enzyme Inhibitors; Epithelial Sodium Channels; Humans; Immediate-Early Proteins; Kinetics; Lung; Morpholines; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Respiratory Mucosa; Sodium; Sodium Channels | 2004 |
Protein kinase A inhibits lysophosphatidic acid induction of serum response factor via alterations in the actin cytoskeleton.
Topics: 1-Methyl-3-isobutylxanthine; Actin Cytoskeleton; Actins; Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Cytoskeleton; Female; Humans; Lysophospholipids; Ovarian Neoplasms; Paxillin; Phosphoproteins; Serum Response Factor; Tumor Cells, Cultured | 2004 |
The rat pancreatic islets: a reliable tool to study islet responses to cholecystokinin receptor occupation.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Animals; Blotting, Western; Colforsin; Fetus; Glucagon; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Microscopy, Confocal; Rats; Receptors, Cholecystokinin; Receptors, Somatostatin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin | 2004 |
Second messengers of octopamine receptors in the snail Lymnaea.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Central Nervous System; Colforsin; Cyclic AMP; Lymnaea; Motor Neurons; Neurons; Phosphodiesterase Inhibitors; Receptors, Biogenic Amine; Second Messenger Systems; Signal Transduction; Time Factors | 2004 |
Myosin heavy chain isoforms expression and cyclic AMP concentrations in hypoxia-induced hypertrophied right ventricle in rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Altitude; Animals; Cell Membrane; Colforsin; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Hypertrophy, Right Ventricular; Hypoxia; Myosin Heavy Chains; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Isoforms; Rats; Rats, Inbred WKY | 2004 |
Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carrier Proteins; Cell Line, Tumor; Colforsin; Cyclic AMP Response Element-Binding Protein; Cyclophosphamide; Down-Regulation; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Humans; Leukemia, T-Cell; Phosphorylation; Receptors, Cell Surface; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Transfection | 2004 |
cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcysteine; Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Colforsin; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Immunoprecipitation; Leupeptins; Luciferases; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Nuclear Receptor Coactivator 2; Protease Inhibitors; Proteasome Endopeptidase Complex; Temperature; Thionucleotides; Time Factors; Transcriptional Activation; Transfection; Ubiquitin | 2004 |
Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenoviridae; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide-Gated Cation Channels; Diterpenes; Feedback; Ion Channels; Isoproterenol; Kinetics; Myocytes, Cardiac; Patch-Clamp Techniques; Rats; Recombinant Proteins; Sarcolemma; Signal Transduction | 2004 |
Empirical bayes gene screening tool for time-course or dose-response microarray data.
Topics: 1-Methyl-3-isobutylxanthine; Algorithms; Animals; Bayes Theorem; Cell Differentiation; Colforsin; DNA, Complementary; Dose-Response Relationship, Drug; False Positive Reactions; Humans; Models, Genetic; Models, Statistical; Oligonucleotide Array Sequence Analysis; Phosphodiesterase Inhibitors | 2004 |
Increase in intracellular Cl- concentration by cAMP- and Ca2+-dependent stimulation of M1 collecting duct cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bacterial Proteins; Biopolymers; Calcium; Catechin; Cell Line; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Diuretics; Epithelial Sodium Channels; Gene Expression; Hydrogen-Ion Concentration; Kidney Tubules, Collecting; Luminescent Proteins; Membrane Potentials; Mice; Mice, Transgenic; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Sodium Channels; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Sulfanilamides | 2005 |
Muscarinic cholinergic regulation of L-type calcium channel in heart of embryonic mice at different developmental stages.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Channels, L-Type; Carbachol; Colforsin; Female; Heart; Mice; Muscarinic Agonists; Myocytes, Cardiac; Patch-Clamp Techniques; Phosphodiesterase Inhibitors | 2004 |
Response to intra- and extracellular lipolytic agents and hormone-sensitive lipase translocation are impaired in adipocytes from rats adapted to a high-protein, carbohydrate-free diet.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Animals; Bucladesine; Colforsin; Dietary Carbohydrates; Dietary Proteins; Glycerol; Isoproterenol; Lipolysis; Male; Rats; Rats, Wistar; Sterol Esterase | 2004 |
Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; B-Lymphocytes; Cell Line; Cell Survival; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; I-kappa B Proteins; Lectins, C-Type; Lipopolysaccharides; MAP Kinase Signaling System; Mast Cells; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Receptors, Antigen, B-Cell; Receptors, IgG; Receptors, Immunologic; Signal Transduction | 2005 |
Fundamental significance of specific phosphodiesterases in the control of spontaneous meiotic resumption in porcine oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Combinations; Female; Gonadotropins, Equine; Meiosis; Oocytes; Phosphodiesterase Inhibitors; Quinolones; Sus scrofa | 2005 |
Cyclic nucleotide signaling mediates an odorant-suppressible chloride conductance in lobster olfactory receptor neurons.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Anthracenes; Chloride Channels; Colforsin; Cyclic AMP; Electric Stimulation; Flufenamic Acid; Imines; Nucleotides, Cyclic; Olfactory Receptor Neurons; Palinuridae; Signal Transduction | 2005 |
Pretreatment with muscarinic receptor agonist activates a calcium-inhibitable adenylate cyclase in GH3 pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Biological Transport; Calcium; Carbachol; Cell Line; Colforsin; Cyclic AMP; Kinetics; Lanthanum; Muscarinic Antagonists; Pituitary Gland; Rats; Receptors, Muscarinic | 2005 |
Effects of MAP kinase pathway and other factors on meiosis of Urechis unicinctus eggs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Annelida; Calcimycin; Chromosomes; Colforsin; Cycloheximide; Diglycerides; Extracellular Signal-Regulated MAP Kinases; Fertilization; Flavonoids; MAP Kinase Signaling System; Meiosis; Okadaic Acid; Ovum; Parthenogenesis; Phosphorylation | 2005 |
Protein secretion in cockroach salivary glands requires an increase in intracellular cAMP and Ca2+ concentrations.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Imines; Insect Proteins; Ionomycin; Ionophores; Male; Periplaneta; Phosphodiesterase Inhibitors; Salivary Glands; Salivary Proteins and Peptides; Serotonin | 2005 |
Signalling pathway in the induction of neurite outgrowth in human mesenchymal stem cells.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Female; Humans; Mesenchymal Stem Cells; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Phosphorylation; Signal Transduction; Time Factors | 2006 |
Pituitary adenylate cyclase-activating polypeptide (PACAP) can act as determinant of the tyrosine hydroxylase phenotype of dopaminergic cells during retina development.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Age Factors; Animals; Animals, Newborn; Blotting, Western; Cell Count; Cell Culture Techniques; Chick Embryo; Colforsin; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Immunohistochemistry; Microscopy, Confocal; Nerve Growth Factors; Neurons; Neuropeptides; Neurotransmitter Agents; Phenotype; Phosphodiesterase Inhibitors; Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Cell Surface; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Retina; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tyrosine 3-Monooxygenase | 2005 |
Role of heterotrimeric G-proteins in lysophosphatidic acid-mediated neurite retraction by RhoA-dependent and -independent mechanisms in N1E-115 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Line; Cell Shape; Colforsin; Dimethyl Sulfoxide; Enzyme Activation; GTP Phosphohydrolases; Heterotrimeric GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Mice; Neurites; Phosphodiesterase Inhibitors; Protein Isoforms; rac1 GTP-Binding Protein; Receptors, Lysophosphatidic Acid; Recombinant Fusion Proteins; rhoA GTP-Binding Protein | 2006 |
cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Gene Expression Regulation; Kidney Medulla; Loop of Henle; Male; Microscopy, Confocal; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1; Vesicle-Associated Membrane Protein 2 | 2006 |
Segmental heterogeneity of electrogenic secretions in human ascending colon and rectum.
Topics: 1-Methyl-3-isobutylxanthine; Carbachol; Chloride Channels; Colforsin; Colon; Cystic Fibrosis Transmembrane Conductance Regulator; Dinoprostone; Electrophoresis, Agar Gel; Electrophysiology; Humans; Intestinal Mucosa; Ion Transport; KCNQ1 Potassium Channel; Rectum; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Effect of aging on corticosterone secretion in diestrous rats.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Aging; Animals; Colforsin; Corticosterone; Cyclic AMP; Diestrus; Estradiol; Female; Progesterone; Prolactin; Rats; Rats, Sprague-Dawley; Signal Transduction | 2006 |
Cyclic nucleotide kinases and tachyzoite-bradyzoite transition in Toxoplasma gondii.
Topics: 1-Methyl-3-isobutylxanthine; Animals; beta-Galactosidase; Cell Differentiation; Chloramphenicol O-Acetyltransferase; Colforsin; Culture Media; Cyclic AMP; Cyclic GMP; Gene Expression Regulation, Developmental; Genes, Protozoan; Genes, Reporter; Heat-Shock Proteins; Life Cycle Stages; Nitroprusside; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Protozoan Proteins; Signal Transduction; Toxoplasma; Toxoplasmosis; Tubulin | 2006 |
ENaC- and CFTR-dependent ion and fluid transport in human middle ear epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Amiloride; Cells, Cultured; Chloride Channels; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Ear, Middle; Epithelial Cells; Epithelial Sodium Channels; Humans; Ion Transport; Nasal Mucosa; Sodium Channels; Water-Electrolyte Balance | 2006 |
Dynein-dynactin complex mediates protein kinase A-dependent clustering of Weibel-Palade bodies in endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dynactin Complex; Dyneins; Endothelium, Vascular; Epinephrine; Humans; Microtubule-Associated Proteins; Microtubule-Organizing Center; Microtubules; Phosphodiesterase Inhibitors; Phosphorylation; Umbilical Veins; Vasoconstrictor Agents; Weibel-Palade Bodies | 2006 |
Protein kinases A and C stimulate the Na+ active transport in frog skeletal muscle without an appreciable change in the number of sarcolemmal Na+ pumps.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport, Active; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; In Vitro Techniques; Muscle, Skeletal; Ouabain; Phosphodiesterase Inhibitors; Protein Binding; Protein Kinase C; Protein Kinases; Ranidae; Sarcolemma; Sodium; Sodium Channels | 2005 |
Base treatment corrects defects due to misfolding of mutant cystic fibrosis transmembrane conductance regulator.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bicarbonates; Cell Line; Chloride Channels; Chlorides; Colforsin; Colon; Cricetinae; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Duodenum; Electrophysiology; Endoplasmic Reticulum; Enzyme Inhibitors; Golgi Apparatus; Hydrogen-Ion Concentration; Ion Transport; Macrolides; Mice; Protein Folding | 2005 |
Pulse stimulation with odors or IBMX/forskolin potentiates responses in isolated olfactory neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Channels; Cell Separation; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Drug Synergism; Electrophysiology; Female; Male; Models, Biological; Necturus; Olfactory Receptor Neurons; Patch-Clamp Techniques; Protein Kinase Inhibitors; Smell; Stimulation, Chemical | 2006 |
Capitalizing on AKT signaling to inhibit hepatocellular carcinoma cell proliferation.
Topics: 1-Methyl-3-isobutylxanthine; 3-Phosphoinositide-Dependent Protein Kinases; 8-Bromo Cyclic Adenosine Monophosphate; Carcinoma, Hepatocellular; Cell Proliferation; Colforsin; Cyclic AMP; Enzyme Activation; Humans; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2005 |
Nitric oxide production from rat adipocytes is modulated by beta3-adrenergic receptor agonists and is involved in a cyclic AMP-dependent lipolysis in adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Adipocytes; Adrenergic Agonists; Adrenergic beta-3 Receptor Agonists; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Lipolysis; Male; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 2006 |
Mercury toxicity in the shark (Squalus acanthias) rectal gland: apical CFTR chloride channels are inhibited by mercuric chloride.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Dithiothreitol; Dogfish; Epithelial Cells; Glutathione; In Vitro Techniques; Male; Membrane Potentials; Mercuric Chloride; Patch-Clamp Techniques; Salt Gland; Xenopus | 2006 |
Hydrocortisone and purinergic signaling stimulate sodium/iodide symporter (NIS)-mediated iodide transport in breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Biological Transport; Breast Neoplasms; Cell Membrane; Cells, Cultured; Colforsin; Female; Humans; Hydrocortisone; Iodides; Phosphodiesterase Inhibitors; Signal Transduction; Symporters; Thyroid Gland; Tretinoin | 2006 |
Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arterioles; Bronchoconstrictor Agents; Caffeine; Calcium; Central Nervous System Stimulants; Colforsin; Cyclic AMP; Enzyme Inhibitors; In Vitro Techniques; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle Contraction; Myocytes, Smooth Muscle; Protein Kinase C; Respiratory System; Ryanodine | 2006 |
Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunit.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Motifs; Amino Acid Sequence; Animals; Blotting, Western; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Endosomal Sorting Complexes Required for Transport; Enzyme Inhibitors; Epithelial Sodium Channels; Molecular Sequence Data; Mutagenesis; Mutation; Nedd4 Ubiquitin Protein Ligases; Oocytes; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Rats; RNA, Complementary; Sodium Channels; Time Factors; Ubiquitin-Protein Ligases; Xenopus laevis; Xenopus Proteins | 2006 |
Differentiation of human bone marrow stem cells into cells with a neural phenotype: diverse effects of two specific treatments.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Antigens, CD; Blotting, Western; Bone Marrow Cells; Cell Differentiation; Cell Size; Cells, Cultured; Child; Colforsin; Fibroblast Growth Factor 1; Flow Cytometry; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Intermediate Filament Proteins; Mercaptoethanol; Microscopy, Electron, Scanning; Nerve Tissue Proteins; Nestin; Neurofilament Proteins; Neurons; Phenotype; Phosphodiesterase Inhibitors; Phosphopyruvate Hydratase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 2006 |
The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Amino Acid Substitution; Animals; Carrier Proteins; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Fibroblasts; Lipid Metabolism; Mice; Perilipin-1; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Serine | 2006 |
Regulation of protein synthesis in Y-organs of the blue crab (Callinectes sapidus): involvement of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Autoradiography; Brachyura; Bucladesine; Colforsin; Cyclic AMP; Cyclic GMP; Cycloheximide; Ecdysteroids; Electrophoresis, Polyacrylamide Gel; Endocrine Glands; Methionine; Protein Biosynthesis; Signal Transduction; Time Factors | 2006 |
Odorant receptors directly activate phospholipase C/inositol-1,4,5-trisphosphate coupled to calcium influx in Odora cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Axons; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Cell Membrane; Cilia; Colforsin; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Fluid; Olfactory Receptor Neurons; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Odorant; Signal Transduction; Smell; Type C Phospholipases | 2006 |
Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factors; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinases; NIH 3T3 Cells; Proto-Oncogene Proteins c-jun; Response Elements; Signal Transduction; Transcription, Genetic | 2006 |
Metaplasticity of the late-phase of long-term potentiation: a critical role for protein kinase A in synaptic tagging.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Female; Hippocampus; In Vitro Techniques; Indoles; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Okadaic Acid; Pyrroles; Signal Transduction; Synapses | 2006 |
Regulation of UT-A1-mediated transepithelial urea flux in MDCK cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Biological Transport; Cell Line; Colforsin; Cyclic AMP; Dogs; Drug Synergism; Enzyme Activation; Isoquinolines; Kidney; Membrane Transport Proteins; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Sulfonamides; Transfection; Urea; Urea Transporters; Vasopressins | 2006 |
Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enteroendocrine Cells; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; MAP Kinase Signaling System; Mice; Phosphodiesterase Inhibitors; Phosphorylation; Proglucagon; Promoter Regions, Genetic; RNA, Messenger; Transcription, Genetic | 2006 |
Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Chemotaxis; Colforsin; Concanavalin A; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipyridamole; Inflammation; Lymphocyte Activation; Mice; Phosphodiesterase Inhibitors; RNA, Messenger; Signal Transduction; Spleen; Time Factors | 2006 |
Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspases; Cell Line, Tumor; Cell Survival; Colforsin; Cyclic AMP; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Insulin-Secreting Cells; Palmitic Acid | 2006 |
Human astrocytes can be induced to differentiate into cells with neuronal phenotype.
Topics: 1-Methyl-3-isobutylxanthine; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Brain; Cell Differentiation; Cell Proliferation; Cells, Cultured; Colforsin; Fetus; Fibroblast Growth Factor 1; Gene Expression; Glial Fibrillary Acidic Protein; Homeodomain Proteins; Humans; Intermediate Filament Proteins; Membrane Potentials; Nerve Tissue Proteins; Nestin; Neurofilament Proteins; Neurons; Phosphopyruvate Hydratase; RNA, Messenger; Synaptophysin; Tetradecanoylphorbol Acetate; Transcription Factor HES-1; Tubulin | 2006 |
Adrenomedullin inhibits insulin exocytosis via pertussis toxin-sensitive G protein-coupled mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Adrenomedullin; Calcium; Cell Line, Tumor; Colforsin; Exocytosis; Formazans; Glucose; GTP-Binding Proteins; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Membrane Potentials; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Phosphodiesterase Inhibitors; Tetrazolium Salts | 2006 |
Cellular mechanisms of carbachol-stimulated Cl- secretion in rat epididymal epithelium.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Carbachol; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Epididymis; Epithelial Cells; Epithelium; Imines; Male; Muscarinic Agonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction | 2006 |
Abnormal regulatory interactions of I148T-CFTR and the epithelial Na+ channel in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Biotinylation; Chlorides; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Epithelial Sodium Channels; Female; Genistein; Humans; Immunoblotting; Injections; Isoleucine; Mice; Mutation; Oocytes; Patch-Clamp Techniques; RNA, Complementary; Threonine; Xenopus | 2007 |
Cardiac hypertrophy diminished the effects of isoproterenol on delayed rectifier potassium current in rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Colforsin; Delayed Rectifier Potassium Channels; Heart; Hypertrophy, Left Ventricular; Isoproterenol; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Potassium; Rats; Rats, Wistar; Signal Transduction; Sympathetic Nervous System; Sympathomimetics | 2006 |
Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cell Adhesion Molecules; Cell Proliferation; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Membranes; Isoenzymes; Male; Microfilament Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Vasoconstriction | 2006 |
Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.
Topics: 1-Methyl-3-isobutylxanthine; AMP-Activated Protein Kinases; Animals; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP; Gene Expression Regulation, Enzymologic; Glucose; Mice; Multienzyme Complexes; Peptides; Phosphodiesterase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Rats | 2006 |
The role of cyclic-AMP on arginase activity by a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Aggregatibacter actinomycetemcomitans; Animals; Arginase; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Lipopolysaccharides; Macrophages; Mice; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protein Synthesis Inhibitors | 2006 |
Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Estradiol; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Phosphorylation; Promoter Regions, Genetic; Signal Transduction; Tamoxifen; Transcription, Genetic | 2007 |
T-type Ca2+ channels contribute to IBMX/forskolin- and K(+)-induced Ca(2+) transients in porcine olfactory receptor neurons.
Topics: 1-Methyl-3-isobutylxanthine; Aniline Compounds; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Male; Mibefradil; Nickel; Olfactory Bulb; Olfactory Receptor Neurons; Phosphodiesterase Inhibitors; Potassium Chloride; Swine; Time Factors; Xanthenes | 2007 |
T-type Ca2+ channels mediate propagation of odor-induced Ca2+ transients in rat olfactory receptor neurons.
Topics: 1-Methyl-3-isobutylxanthine; Aniline Compounds; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Immunohistochemistry; Male; Mibefradil; Microscopy, Confocal; Nickel; Odorants; Olfactory Bulb; Olfactory Receptor Neurons; Phosphodiesterase Inhibitors; Potassium Chloride; Rats; Rats, Wistar; Time Factors; Xanthenes | 2007 |
Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chlorides; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Female; Humans; In Vitro Techniques; Ion Transport; Mice; Mutation; Oocytes; Patch-Clamp Techniques; Protein Binding; Xenopus laevis | 2007 |
Tyrosine phosphorylation of rabphilin during long-lasting long-term potentiation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding Sites; Colforsin; Enzyme Inhibitors; Genistein; Hippocampus; Long-Term Potentiation; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neural Pathways; Organ Culture Techniques; Phosphodiesterase Inhibitors; Phosphorylation; Presynaptic Terminals; Synaptic Transmission; Tyrosine | 2007 |
Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Analgesics, Opioid; Blotting, Western; Cell Line; Colforsin; Cyclic AMP; Cysteine; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression; Glioma; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Mutation; Pertussis Toxin; Phosphodiesterase Inhibitors; Receptors, Opioid, mu; Time Factors; Transfection | 2006 |
Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Anthracenes; Cell Communication; Cell Differentiation; Cell Line; Colforsin; Connexin 43; Connexins; Epithelial Cells; Gap Junction delta-2 Protein; Gap Junctions; Humans; Nicotiana; Pancreatic Ducts; Reverse Transcriptase Polymerase Chain Reaction; Smoke; Telomerase | 2007 |
Identification of new small molecule inhibitors of cystic fibrosis transmembrane conductance regulator protein: in vitro and in vivo studies.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Apigenin; Bucladesine; Carbachol; Cell Line, Tumor; Chloride Channels; Cholera Toxin; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Humans; Intestinal Mucosa; Intestines; Jejunum; Luminescent Proteins; Mice; Mice, Inbred ICR; Molecular Structure; Phosphodiesterase Inhibitors; Rats; Sulfonamides; Tetrahydronaphthalenes; Thiazoles | 2007 |
NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Kidney; Kidney Tubules, Proximal; Male; Microvilli; Parathyroid Hormone; Phosphodiesterase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Serine; Sodium; Sodium Radioisotopes; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Stimulation, Chemical | 2007 |
Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcitonin; Cartilage, Articular; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Endopeptidases; Female; Glycosaminoglycans; Matrix Metalloproteinases; Oncostatin M; Osteoarthritis; Phosphodiesterase Inhibitors; Tumor Necrosis Factor-alpha | 2007 |
Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions.
Topics: 1-Methyl-3-isobutylxanthine; Blood Platelets; Bucladesine; Calcium; Cell Adhesion Molecules; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Indazoles; Kinetics; Microfilament Proteins; Nucleotides, Cyclic; Oligopeptides; Peptide Fragments; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Thionucleotides; Thrombin | 2007 |
Self-renewal and differentiation of mouse embryonic stem cells as measured by Oct4 expression: the role of the cAMP/PKA pathway.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Culture Techniques; Cell Differentiation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Embryonic Stem Cells; Mice; Octamer Transcription Factor-3; Phosphodiesterase Inhibitors; Signal Transduction; Tretinoin | 2007 |
Control of cyclic AMP concentration in bovine endometrial stromal cells by arachidonic acid.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Arachidonic Acid; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Cyclooxygenase 2; Depression, Chemical; Dinoprostone; Endometrium; Female; Indoles; Maleimides; Paracrine Communication; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Kinase C; Stromal Cells; Tetradecanoylphorbol Acetate | 2007 |
Involvement of hyperpolarization-activated cation channels in synaptic modulation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Neural Pathways; Neurons; Phosphodiesterase Inhibitors; Potassium; Potassium Channel Blockers; Potassium Channels; Presynaptic Terminals; Pyrimidines; Rats; Rats, Wistar; Synaptic Membranes; Synaptic Transmission | 2007 |
Cyclic AMP triggers glucagon-like peptide-1 secretion from the GLUTag enteroendocrine cell line.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Colforsin; Cyclic AMP; Enteroendocrine Cells; Glucagon-Like Peptide 1; Humans; Ion Channels; Membrane Potentials | 2007 |
Post- and pre-synaptic action of isotocin in the upper esophageal sphincter muscle of the eel: its role in water drinking.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Anesthetics, Local; Anguilla; Animals; Colforsin; Dose-Response Relationship, Drug; Drinking Behavior; Esophageal Sphincter, Upper; Muscle Contraction; Oxytocin; Phosphodiesterase Inhibitors; Presynaptic Terminals; Synapses; Tetrodotoxin | 2007 |
Regulation of C/EBPbeta mRNA expression and C/EBPbeta promoter activity by protein kinases A and C in a myelomonocytic cell line (HD11).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Chickens; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Humans; Mice; Molecular Sequence Data; Monocytes; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Protein Kinase C; RNA Stability; RNA, Messenger; Sequence Alignment; Signal Transduction; Tetradecanoylphorbol Acetate | 2007 |
Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Blotting, Western; Calcium; Carbachol; Cholinergic Agonists; Colforsin; Cyclic AMP; Cyclic CMP; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activators; Epidermal Growth Factor; In Vitro Techniques; Lacrimal Apparatus; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Peroxidases; Phenylephrine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Vasoactive Intestinal Peptide | 2007 |
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Line; Chlorocebus aethiops; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Extracellular Fluid; Gene Expression Regulation; Humans; Immunoprecipitation; Nerve Tissue Proteins; Phosphodiesterase Inhibitors; Phosphorylation; Protein Isoforms; Transfection | 2007 |
Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Apiaceae; Cell Death; Colforsin; Gene Expression Regulation, Neoplastic; Melanins; Melanoma; Mice; Monophenol Monooxygenase; Plant Extracts; RNA, Messenger | 2007 |
Rho GTPase and cAMP/protein kinase A signaling mediates myocilin-induced alterations in cultured human trabecular meshwork cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Adult; Blotting, Western; Cell Adhesion; Cells, Cultured; Child; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Enzyme Activation; Eye Proteins; Fibronectins; Glycoproteins; Green Fluorescent Proteins; Humans; Microscopy, Fluorescence; Middle Aged; Models, Biological; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; Signal Transduction; Trabecular Meshwork; Transfection | 2008 |
Potentiation of ATP- and bradykinin-induced [Ca2+]c responses by PTHrP peptides in the HaCaT cell line.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Bradykinin; Calcium; Carbazoles; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; Humans; Indoles; Keratinocytes; Parathyroid Hormone-Related Protein; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Signal Transduction | 2008 |
Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs.
Topics: 1-Methyl-3-isobutylxanthine; Adaptor Proteins, Signal Transducing; Animals; Cell Line; Colforsin; Exocytosis; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Intracellular Signaling Peptides and Proteins; Mice; MicroRNAs; Proteins; rab GTP-Binding Proteins; rab27 GTP-Binding Proteins; rab3A GTP-Binding Protein; Synapsins; Synaptosomal-Associated Protein 25; Vesicular Transport Proteins | 2008 |
Suppression of carbachol-induced oscillatory Cl- secretion by forskolin in rat parotid and submandibular acinar cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antiporters; Carbachol; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Gramicidin; Male; Muscarinic Agonists; Parotid Gland; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Submandibular Gland | 2008 |
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Dipyridamole; Female; Guanylate Cyclase; Histamine; Humans; In Vitro Techniques; Isoenzymes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthyridines; Nitroprusside; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Serotonin; Umbilical Arteries; Vasodilator Agents | 2008 |
Pharmacological attenuation of Paramecium fluid-phase endocytosis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Endocytosis; Isoquinolines; Paramecium; Protein Kinase Inhibitors | 2007 |
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide-Gated Cation Channels; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Guanylate Cyclase; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2008 |
Insulin-secreting L-cells for the treatment of insulin-dependent diabetes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Diabetes Mellitus; Drug Resistance; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Neomycin; Proinsulin; Transfection | 2008 |
Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cell Line; Cell Line, Tumor; Chromogranin B; Colforsin; Cytoplasmic Granules; Enzyme-Linked Immunosorbent Assay; Glucose; Image Processing, Computer-Assisted; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ionomycin; Microscopy, Immunoelectron; Rats | 2008 |
Effect of xanthohumol on melanogenesis in B16 melanoma cells.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Animals; Cell Line; Cell Survival; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Drug Antagonism; Flavonoids; Humulus; Intramolecular Oxidoreductases; Melanins; Melanocytes; Melanoma, Experimental; Membrane Glycoproteins; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases; Propiophenones; Signal Transduction | 2008 |
Chloride conductance in amphibian skin: regulatory control in the skin of Rana pipiens.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chlorides; Colforsin; Cyclic AMP; Electric Conductivity; Epinephrine; Galvanic Skin Response; In Vitro Techniques; Isoproterenol; Rana pipiens; Skin Physiological Phenomena | 2008 |
Sympathetic nervous system modulates the ocular hypotensive action of MT2-melatonin receptors in normotensive rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Adrenergic beta-Agonists; Albuterol; Animals; Aqueous Humor; Colforsin; Dose-Response Relationship, Drug; Intraocular Pressure; Isoindoles; Melatonin; Ocular Hypertension; Okadaic Acid; Rabbits; Receptor, Melatonin, MT2; Sympathectomy, Chemical; Sympathetic Nervous System; Terbutaline | 2008 |
Assessment of CFTR function after gene transfer in vitro and in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Separation; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Humans; Ion Transport; Luciferases; Mice; Respiratory System; Transfection | 2008 |
Protein kinase A modulates A-type potassium currents of larval zebrafish (Danio rerio) white muscle fibres.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Action Potentials; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Embryo, Nonmammalian; Female; Isoquinolines; Male; Muscle Fibers, Fast-Twitch; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Stimulation, Chemical; Sulfonamides; Zebrafish | 2009 |
Cyclic-AMP-dependent proliferation of a human osteoblast cell line (HOS cells) induced by hydroxyapatite: effect of exogenous nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Arginase; Cell Communication; Cell Differentiation; Cell Line; Colforsin; Colorimetry; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dichlororibofuranosylbenzimidazole; Durapatite; Guanylate Cyclase; Humans; Nitric Oxide; Nitric Oxide Donors; Osteoblasts; Penicillamine; Phosphodiesterase Inhibitors; Rolipram; S-Nitroso-N-Acetylpenicillamine | 2008 |
Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic CMP; G-Protein-Coupled Receptor Kinases; Gene Expression; Humans; Light; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphorylation; Retinal Cone Photoreceptor Cells; Serine; Swine; Time Factors; Transfection; Xenopus laevis; Zebrafish | 2008 |
Relaxin signalling in primary cultures of human myometrial cells.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Cyclic AMP; Female; Humans; Insulin; Myometrium; Proteins; Receptors, G-Protein-Coupled; Receptors, Peptide; Relaxin; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2008 |
Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding Sites; Carrier Proteins; Cells, Cultured; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Energy Transfer; Humans; Immunoprecipitation; Phosphodiesterase 4 Inhibitors; Phosphorylation; Protein Conformation; Protein Isoforms | 2008 |
Amyloid peptide inhibits ATP release from human erythrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amyloid beta-Peptides; Animals; Caspase 3; Caspase Inhibitors; Colforsin; Cyclic AMP; Enzyme Activation; Erythrocytes; Humans; Intercellular Signaling Peptides and Proteins; Oxygen; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Phosphofructokinases | 2008 |
Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Disease Models, Animal; Hypertension, Pulmonary; Milrinone; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Potassium Channels, Calcium-Activated; Protein Kinase C; Pulmonary Artery; Purinones; Rats; Vasoconstriction | 2008 |
Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; alpha-MSH; Cell Line, Tumor; Colforsin; Cyclic AMP; Guanine Nucleotide Exchange Factors; Humans; Ligands; MAP Kinase Signaling System; Melanoma; Microvessels; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled; Shelterin Complex; Signal Transduction; Telomere-Binding Proteins; Vasoactive Intestinal Peptide | 2009 |
Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, P-Type; Calcium Channels, Q-Type; Calcium Signaling; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Glutamate Decarboxylase; Image Processing, Computer-Assisted; Mice; Mice, Inbred C57BL; Phosphodiesterase Inhibitors; Receptors, G-Protein-Coupled; Receptors, Presynaptic; Reverse Transcriptase Polymerase Chain Reaction; Second Messenger Systems; Taste Buds | 2009 |
Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carrier Proteins; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exocytosis; Glucose; Green Fluorescent Proteins; Immunoblotting; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Isoquinolines; Mice; Microscopy, Fluorescence; Microscopy, Immunoelectron; Mitochondrial Proteins; Okadaic Acid; Phosphorylation; Protein Transport; rab GTP-Binding Proteins; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Transfection | 2009 |
Cyclic AMP-dependent activation of rhodopsin gene transcription in cultured retinal precursor cells of chicken embryo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arrestin; Cell Differentiation; Cell Membrane; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 6; Gene Expression Regulation; Phosphodiesterase Inhibitors; Photoreceptor Cells, Vertebrate; Potassium Chloride; Promoter Regions, Genetic; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Rhodopsin; RNA, Messenger; Stem Cells; Transcriptional Activation; Transducin; Up-Regulation | 2009 |
Phosphodiesterase inhibition by naloxone augments the inotropic actions of beta-adrenergic stimulation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Cardiotonic Agents; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Myocardium; Naloxone; Narcotic Antagonists; Papillary Muscles; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors | 2009 |
cAMP stimulates apical exocytosis of the renal Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in the thick ascending limb: role of protein kinase A.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Membrane; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Exocytosis; Guanine Nucleotide Exchange Factors; Isoquinolines; Male; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Solute Carrier Family 12, Member 1; Sulfonamides | 2009 |
Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Colforsin; Gene Expression Regulation, Developmental; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Islets of Langerhans; Melatonin; Rats; Rats, Wistar | 2009 |
POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Blotting, Western; Caco-2 Cells; CDX2 Transcription Factor; Cell Line; Cells, Cultured; Chromatin Immunoprecipitation; Colforsin; Cyclic AMP; Gene Expression Regulation; Homeodomain Proteins; Humans; Islets of Langerhans; Molecular Sequence Data; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Octamer Transcription Factor-1; Promoter Regions, Genetic; Protein Binding; Rats; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Trans-Activators | 2009 |
Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Apoptosis; Breast Neoplasms; Carbazoles; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p27; Female; G1 Phase; Humans; Leptin; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction | 2009 |
Molecular mechanisms mediating protective effect of cAMP on lipopolysaccharide (LPS)-induced human lung microvascular endothelial cells (HLMVEC) hyperpermeability.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Antigens, CD; Cadherins; Capillary Permeability; Cell Adhesion Molecules; Colforsin; Contractile Proteins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electric Impedance; Endothelial Cells; Endothelium, Vascular; Filamins; Guanine Nucleotide Exchange Factors; Humans; Lipopolysaccharides; Lung; Membrane Proteins; Microfilament Proteins; Phosphoproteins; Phosphorylation; RNA, Small Interfering; Zonula Occludens-1 Protein | 2009 |
Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Cell Line; CHO Cells; Colforsin; Cricetinae; Cricetulus; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Proteins; HL-60 Cells; Humans; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Signal Transduction; Uridine Diphosphate; Uridine Diphosphate Glucose | 2009 |
Nitric oxide and cyclic nucleotide signal transduction modulates synaptic vesicle turnover in human model neurons.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Cell Differentiation; Cell Line, Tumor; Colforsin; Cyclic GMP; Enzyme Inhibitors; Exocytosis; Humans; Isoquinolines; Microtubule-Associated Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroso Compounds; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Pyridinium Compounds; Quaternary Ammonium Compounds; Signal Transduction; Sulfonamides; Synapsins; Synaptic Vesicles; Synaptotagmin I; Teratocarcinoma; Time Factors | 2009 |
CFTR and tight junctions in cultured bronchial epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Bronchi; Cell Line; Cell Membrane Permeability; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytoskeleton; Electric Conductivity; Humans; Lanthanum; Mannitol; Respiratory Mucosa; Tight Junctions; Time Factors; Tubulin | 2010 |
Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipocytes; Adipokines; Adiponectin; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Inflammation; Insulin Resistance; Isoquinolines; Mice; Peptides; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Receptors, Glucagon; RNA, Messenger; Sulfonamides; Venoms | 2009 |
Effect of hydrogen sulfide on cyclic AMP production in isolated bovine and porcine neural retinae.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Air Pollutants; Animals; Cattle; Colforsin; Cyclic AMP; Hydrogen Sulfide; In Vitro Techniques; Neurons; Phosphodiesterase Inhibitors; Retina; Sulfides; Swine | 2010 |
Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Apoptosis Regulatory Proteins; Caspases; Cell Death; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Fatty Acids; Hep G2 Cells; Humans; Intracellular Signaling Peptides and Proteins; Mitochondria; Mitochondrial Proteins; Oxidation-Reduction; Palmitates; Phosphodiesterase Inhibitors; Reactive Oxygen Species; Triglycerides | 2010 |
The identification of inhibitors of Schistosoma mansoni miracidial transformation by incorporating a medium-throughput small-molecule screen.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anthelmintics; Benzophenanthridines; Calcimycin; Calcium Channel Blockers; Citalopram; Clomipramine; Colforsin; Cyclic AMP; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Immunohistochemistry; Mice; Schistosoma mansoni; Tetradecanoylphorbol Acetate; Triflupromazine | 2010 |
ADP-ribosylation factor 6 modulates adrenergic stimulated lipolysis in adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adrenergic beta-Agonists; Animals; Colforsin; Endocytosis; Insulin; Isoproterenol; Lipolysis; Mice; Mice, Obese; Phosphodiesterase Inhibitors; RNA Interference; RNA, Small Interfering; Signal Transduction; Triglycerides | 2010 |
AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon.
Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Acetazolamide; Amiloride; Animals; Animals, Newborn; Anion Transport Proteins; Anions; Antiporters; Bicarbonates; Bumetanide; Carbonic Anhydrase II; Carbonic Anhydrase III; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cation Transport Proteins; Cecum; Chlorides; Colforsin; Colon; Cyclic AMP; Electrophysiological Phenomena; Gene Expression; Ion Channels; Ion Pumps; Mice; Mice, Inbred Strains; Mice, Knockout; SLC4A Proteins; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2 | 2010 |
Strain-dependent differences in electrogenic secretion of electrolytes across mouse colon epithelium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Barium; Bumetanide; Carbachol; Colforsin; Colon; Cyclic AMP; Electrolytes; Feces; Histamine; Histamine Antagonists; Intestinal Mucosa; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Muscarinic Antagonists; Potassium; Receptors, Histamine H1; Receptors, Muscarinic; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Water | 2010 |
Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzophenanthridines; CA3 Region, Hippocampal; Catalytic Domain; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Interneurons; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Male; Mossy Fibers, Hippocampal; Organ Culture Techniques; Peptide Fragments; Phorbol Esters; Phosphodiesterase Inhibitors; Protein Kinase C; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Signal Transduction; Synaptic Membranes; Synaptic Transmission | 2010 |
Somatostatin signaling in neuronal cilia is critical for object recognition memory.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenylyl Cyclases; Amides; Animals; Behavior, Animal; Bicuculline; Biophysics; CA1 Region, Hippocampal; Cilia; Colforsin; Cyclic AMP; Discrimination, Psychological; Electric Stimulation; Female; GABA Antagonists; In Vitro Techniques; Isoquinolines; Locomotion; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuropsychological Tests; Nitrobenzenes; Phosphodiesterase Inhibitors; Receptors, Somatostatin; Recognition, Psychology; Signal Transduction; Somatostatin | 2010 |
Grueneberg ganglion neurons are finely tuned cold sensors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Calcium; Calcium Signaling; Cold Temperature; Colforsin; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Ganglia, Sensory; Green Fluorescent Proteins; In Vitro Techniques; Isothiocyanates; Mice; Mice, Transgenic; Microscopy, Confocal; Nasal Cavity; Olfactory Bulb; Olfactory Marker Protein; Olfactory Pathways; Phosphodiesterase Inhibitors; Pyrimidinones; Sensory Receptor Cells; Sodium Channel Blockers; Tetrodotoxin; Thermosensing; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2010 |
Taurine supplementation: involvement of cholinergic/phospholipase C and protein kinase A pathways in potentiation of insulin secretion and Ca2+ handling in mouse pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carbachol; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Dietary Supplements; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Phorbol Esters; Phospholipase C beta; Protein Kinase C-alpha; Taurine | 2010 |
Voltage-gated K+ channels play a role in cAMP-stimulated neuritogenesis in mouse neuroblastoma N2A cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Cell Differentiation; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Silencing; Intracellular Space; Ion Channel Gating; Mice; Neurites; Neuroblastoma; Neurogenesis; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Kinase Inhibitors; Sodium Channels; Valinomycin | 2011 |
cAMP modulates intracellular Ca2+ sensitivity of fast-releasing synaptic vesicles at the calyx of Held synapse.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Allosteric Regulation; Animals; Calcium; Calcium Channels; Calcium Signaling; Cochlear Nucleus; Colforsin; Cyclic AMP; Egtazic Acid; Excitatory Postsynaptic Potentials; Patch-Clamp Techniques; Photolysis; Rats; Rats, Wistar; Second Messenger Systems; Synaptic Vesicles | 2010 |
Simulated physiological oocyte maturation (SPOM): a novel in vitro maturation system that substantially improves embryo yield and pregnancy outcomes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Cattle; Cell Communication; Cells, Cultured; Chorionic Gonadotropin; Colforsin; Culture Media, Serum-Free; Cumulus Cells; Cyclic AMP; Embryo Implantation; Embryo, Mammalian; Embryonic Development; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Gap Junctions; Mice; Oocytes; Oogenesis; Pregnancy; Pregnancy Outcome; Quinolones | 2010 |
Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Berberine; Carrier Proteins; Catecholamines; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Hypoglycemic Agents; Lipolysis; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Perilipin-1; Phosphodiesterase Inhibitors; Phosphoproteins; Sterol Esterase | 2011 |
Evidence for basolateral Cl- channels as modulators of apical Cl- secretion in pulmonary epithelia of Xenopus laevis.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Cell Polarity; Chloride Channels; Chloride-Bicarbonate Antiporters; Chlorides; Colforsin; Epithelial Cells; Female; In Vitro Techniques; Lung; Membrane Potentials; Nitrobenzoates; Nystatin; ortho-Aminobenzoates; Permeability; Time Factors; Xenopus laevis | 2011 |
Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol.
Topics: 1-Methyl-3-isobutylxanthine; Adaptation, Physiological; Adenylyl Cyclases; Analysis of Variance; Animals; Animals, Genetically Modified; Behavior, Animal; Brain; Cells, Cultured; Central Nervous System Depressants; Colforsin; Corticotropin-Releasing Hormone; Defense Mechanisms; Drug Interactions; Enzyme Inhibitors; Ethanol; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Larva; Light; Melanocytes; Mutation; Nystagmus, Optokinetic; Oligodeoxyribonucleotides, Antisense; Pro-Opiomelanocortin; Receptors, Corticotropin-Releasing Hormone; Skin; Time Factors; Zebrafish; Zebrafish Proteins | 2011 |
Metformin counters both lipolytic/inflammatory agents-decreased hormone sensitive lipase phosphorylation at Ser-554 and -induced lipolysis in human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adult; Aged; Colforsin; Female; Humans; Hypoglycemic Agents; Inflammation; Interleukin-1beta; Isoproterenol; Lipolysis; Lipopolysaccharides; Male; Metformin; Middle Aged; Phosphorylation; Primary Cell Culture; Serine; Sterol Esterase; Tumor Necrosis Factor-alpha | 2011 |
Linalool from rosewood (Aniba rosaeodora Ducke) oil inhibits adenylate cyclase in the retina, contributing to understanding its biological activity.
Topics: 1-Methyl-3-isobutylxanthine; Acyclic Monoterpenes; Adenylyl Cyclase Inhibitors; Animals; Central Nervous System Agents; Chickens; Colforsin; Cyclic AMP; Enzyme Inhibitors; Inhibitory Concentration 50; Lauraceae; Monoterpenes; Oils, Volatile; Phosphoric Diester Hydrolases; Plant Extracts; Receptors, Purinergic P1; Retina | 2012 |
Development of a cyclic adenosine monophosphate assay for Gi-coupled G protein-coupled receptors by utilizing the endogenous calcitonin activity in Chinese hamster ovary cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Calcitonin; Cell Culture Techniques; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Female; Humans; Inhibitory Concentration 50; Ligands; Molecular Targeted Therapy; Naloxone; Narcotic Antagonists; Phosphodiesterase Inhibitors; Radioligand Assay; Rats; Receptors, Calcitonin; Receptors, G-Protein-Coupled; Receptors, Islet Amyloid Polypeptide; Receptors, Opioid, mu; Salmon | 2011 |
Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; ATP-Binding Cassette Transporters; Biological Clocks; Caffeine; Colforsin; Cyclic AMP; Drug Interactions; Female; Glyburide; KATP Channels; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Oviducts; Phosphodiesterase Inhibitors; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2011 |
Caffeine activates tumor suppressor PTEN in sarcoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Agents; Caffeine; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colforsin; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Humans; Microfilament Proteins; Models, Biological; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Sarcoma | 2011 |
Cyclic AMP-induced p53 destabilization is independent of EPAC in pre-B acute lymphoblastic leukemia cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Apoptosis; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Damage; Doxorubicin; Gene Expression Regulation, Leukemic; Guanine Nucleotide Exchange Factors; Histone Deacetylase 1; Humans; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Stability; Proto-Oncogene Proteins c-mdm2; RNA, Messenger; Tumor Suppressor Protein p53 | 2011 |
CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca²⁺-activated Cl⁻ conductance.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Chloride Channels; Colforsin; Cyclooxygenase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Genistein; HEK293 Cells; Humans; Ion Channel Gating; Niflumic Acid; Oocytes; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protons; Xenopus laevis | 2011 |
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Allyl Compounds; Animals; Ankyrins; Behavior, Animal; Calcium; Calcium Channels; Capsaicin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Hydrogen-Ion Concentration; Hyperalgesia; Inhibitory Postsynaptic Potentials; Ion Channel Gating; Isocyanates; Maleimides; Membrane Potentials; Mice; Mice, Inbred Strains; Mice, Knockout; Miniature Postsynaptic Potentials; Neurons; Nociception; Nociceptive Pain; Oocytes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spermine; Synaptic Transmission; Tachyphylaxis; Transient Receptor Potential Channels; Trigeminal Caudal Nucleus; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Xenopus laevis | 2011 |
cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.
Topics: 1-Methyl-3-isobutylxanthine; Adaptor Proteins, Signal Transducing; Adenylate Kinase; Amino Acids; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line; Colforsin; Cyclic AMP; Eukaryotic Initiation Factors; Gene Deletion; Gene Knockout Techniques; Humans; Insulin; Mechanistic Target of Rapamycin Complex 1; Mice; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Neuropeptides; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinases; Proteins; Ras Homolog Enriched in Brain Protein; Recombinant Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factors; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2011 |
The role of rectal chloride secretion in childhood constipation.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Biopsy; Carbachol; Child; Chlorides; Cholinergic Agonists; Colforsin; Constipation; Cystic Fibrosis Transmembrane Conductance Regulator; Defecation; Female; Hirschsprung Disease; Histamine; Histamine Agonists; Humans; Male; Phosphodiesterase Inhibitors; Rectum; Sodium Channel Blockers | 2011 |
Neurotransmitter influence on human meibomian gland epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Calcium; Carbachol; Cell Division; Cell Line, Transformed; Cholinergic Agonists; Colforsin; Epithelial Cells; Humans; Meibomian Glands; Parasympathetic Fibers, Postganglionic; Phosphodiesterase Inhibitors; Receptors, Muscarinic; Vasoactive Intestinal Peptide | 2011 |
CFTR and TMEM16A are separate but functionally related Cl- channels.
Topics: 1-Methyl-3-isobutylxanthine; Anoctamin-1; Calcium; Cell Line; Chloride Channels; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Gene Expression Regulation; HEK293 Cells; Humans; Neoplasm Proteins; RNA Interference; RNA, Small Interfering | 2011 |
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glioblastoma; Guanine Nucleotide Exchange Factors; Humans; Isoquinolines; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Rolipram; Shelterin Complex; Signal Transduction; Sulfonamides; Telomere-Binding Proteins; Theophylline | 2012 |
Dopaminergic modulation of ganglion-cell photoreceptors in rat.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Actins; Animals; Carbazoles; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine; Dopamine Agonists; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation; In Vitro Techniques; Light; Light Signal Transduction; Male; Membrane Potentials; Patch-Clamp Techniques; Photic Stimulation; Photoreceptor Cells; Pyrroles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Retina; Retinal Ganglion Cells; Rod Opsins; Sodium Channel Blockers; Tetrodotoxin; Visual Pathways | 2012 |
Aptameric peptide for one-step detection of protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Aptamers, Peptide; Biosensing Techniques; Cell Line, Tumor; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dielectric Spectroscopy; Electrodes; Gold; Histidine; Humans; Immobilized Proteins; Kinetics; Limit of Detection; Nitrilotriacetic Acid; Oligopeptides; Protein Kinase Inhibitors; Quartz Crystal Microbalance Techniques | 2012 |
CFTR-mediated Cl(-) transport in the acinar and duct cells of rabbit lacrimal gland.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acinar Cells; Animals; Benzoates; Biological Transport; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Female; Fluorescent Dyes; Lacrimal Apparatus; Microscopy, Confocal; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rabbits; Thiazolidines | 2012 |
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Colforsin; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Humans; Insulin-Secreting Cells; Insulinoma; Melatonin; Microscopy, Confocal; Pancreatic Neoplasms; Phosphorylation; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Time Factors; Transfection; Tryptamines | 2012 |
20β-hydroxysteroid dehydrogenase gene promoter: potential role for cyclic AMP and xenobiotic responsive elements.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; beta-Naphthoflavone; Catfishes; Colforsin; Cortisone Reductase; Cyclic AMP; DNA; Female; Gene Expression; HEK293 Cells; Humans; Molecular Sequence Data; Oncorhynchus mykiss; Ovary; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Recombinant Proteins; Species Specificity; Xenobiotics | 2012 |
Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis.
Topics: 1-Methyl-3-isobutylxanthine; Biomarkers; Biopsy; Carbachol; Chlorides; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Genotype; Humans; Ion Channel Gating; Prognosis; Rectum; Treatment Outcome | 2012 |
Regulation of sheep oocyte maturation using cAMP modulators.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Embryo, Mammalian; Embryonic Development; Female; Follicle Stimulating Hormone; In Vitro Oocyte Maturation Techniques; Oocytes; Oogenesis; Osmolar Concentration; Phosphodiesterase Inhibitors; Quality Control; Quinolones; Sheep | 2013 |
Primary culture of embryonic rat olfactory receptor neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cells, Cultured; Colforsin; Female; Microscopy, Fluorescence; Olfactory Receptor Neurons; Pregnancy; Rats | 2012 |
Rapid stimulation of human renal ENaC by cAMP in Xenopus laevis oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antidiuretic Agents; Brefeldin A; Cell Membrane; Colforsin; Cyclic AMP; Epithelial Sodium Channels; Gene Expression; Humans; Oocytes; Patch-Clamp Techniques; Time Factors; Vasopressins; Xenopus laevis | 2013 |
cAMP/protein kinase A activates cystic fibrosis transmembrane conductance regulator for ATP release from rat skeletal muscle during low pH or contractions.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Benzoates; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Glyburide; Hydrogen-Ion Concentration; Lactic Acid; Male; Muscle Contraction; Muscle, Skeletal; Myoblasts; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Thiazolidines | 2012 |
Interactions between hERG and KCNQ1 α-subunits are mediated by their COOH termini and modulated by cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Cells, Cultured; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; HEK293 Cells; Humans; KCNQ1 Potassium Channel; Male; Phosphodiesterase Inhibitors; Rabbits | 2013 |
Reversible meiotic arrest in feline oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Blastocyst; Cats; Cells, Cultured; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Embryo Culture Techniques; Enzyme Activation; Enzyme Activators; Epidermal Growth Factor; Female; Fertilization in Vitro; In Vitro Oocyte Maturation Techniques; M Phase Cell Cycle Checkpoints; Meiosis; Oocytes; Phosphodiesterase Inhibitors; Time Factors | 2014 |
Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.
Topics: 1-Methyl-3-isobutylxanthine; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Gene Expression; HEK293 Cells; Humans; Interleukin-2; Interleukin-2 Receptor beta Subunit; Janus Kinase 3; Phosphorylation; Protein Binding; Protein Subunits; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes | 2013 |
The h-current in periglomerular dopaminergic neurons of the mouse olfactory bulb.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Benzazepines; Colforsin; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Dopamine; Dopaminergic Neurons; Green Fluorescent Proteins; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ivabradine; Kinetics; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Norepinephrine; Olfactory Bulb; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Rats; Tyrosine 3-Monooxygenase | 2013 |
Striatal neurones have a specific ability to respond to phasic dopamine release.
Topics: 1-Methyl-3-isobutylxanthine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Biosensing Techniques; Colforsin; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dopamine; Dopamine Agonists; Dopamine and cAMP-Regulated Phosphoprotein 32; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Neurons; Phosphodiesterase Inhibitors; Prefrontal Cortex; Proto-Oncogene Proteins c-fos | 2013 |
Heparin and cAMP modulators interact during pre-in vitro maturation to affect mouse and human oocyte meiosis and developmental competence.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Colforsin; Cross-Sectional Studies; Embryo Culture Techniques; Energy Metabolism; Female; Heparin; Humans; In Vitro Oocyte Maturation Techniques; Meiosis; Mice; Oocyte Retrieval; Oocytes | 2013 |
cAMP-mediated stabilization of fusion pores in cultured rat pituitary lactotrophs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Exocytosis; Lactotrophs; Male; Membrane Fusion; Membrane Potentials; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pituitary Gland; Prolactin; Rats; Rats, Wistar | 2013 |
cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC.
Topics: 1-Methyl-3-isobutylxanthine; Adenocarcinoma; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Focal Adhesions; Guanine Nucleotide Exchange Factors; Humans; Neoplasm Invasiveness; Pancreatic Neoplasms; Paxillin; Protein Transport | 2013 |
Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipogenesis; Animals; Cell Differentiation; Cell Nucleus; Chromatin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Mice; Mitochondria; Peptides; Protein Binding; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Transport; Receptors, Glucocorticoid; RNA, Small Interfering; Signal Transduction; Tacrolimus Binding Proteins | 2013 |
Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Deoxycytidine; Enzyme Inhibitors; Gemcitabine; Humans; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Pyridines; Quinolones; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; Vasodilator Agents | 2015 |
In vitro characterization of acid secretion in the gilthead sea bream (Sparus aurata) stomach.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Colforsin; Cyclic AMP; Electric Impedance; Gadolinium; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Macrolides; Muscarinic Agonists; Omeprazole; Proton Pump Inhibitors; Receptors, Calcium-Sensing; Sea Bream | 2014 |
Activation of chloride secretion by isoflavone genistein in endometrial epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Bumetanide; Cell Membrane Permeability; Cells, Cultured; Chlorides; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Egtazic Acid; Endometrium; Epithelial Cells; Estradiol; Female; Fulvestrant; Genistein; Glyburide; Swine; Uridine Triphosphate | 2013 |
Effects of different oocyte retrieval and in vitro maturation systems on bovine embryo development and quality.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Cattle; Colforsin; Culture Media; DNA Methylation; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; In Vitro Oocyte Maturation Techniques; Male; Oocyte Retrieval; Quinolones | 2015 |
Inhibition of interleukin-1β production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Extracellular Fluid; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hydrogen-Ion Concentration; I-kappa B Proteins; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; NF-kappa B; NF-KappaB Inhibitor alpha; Poly I-C; Receptors, G-Protein-Coupled; RNA, Messenger; Second Messenger Systems | 2014 |
Dynamics of β-adrenergic/cAMP signaling and morphological changes in cultured astrocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Agents; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Flow Cytometry; Glial Fibrillary Acidic Protein; Guanine Nucleotide Exchange Factors; Luminescent Proteins; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Signal Transduction; Time Factors | 2014 |
Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Ciliary Neurotrophic Factor; Colforsin; Cyclic AMP; Embryonic Stem Cells; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; Humans; Induced Pluripotent Stem Cells; Motor Neurons; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases | 2014 |
In vivo screening for substrates of protein kinase A using a combination of proteomic approaches and pharmacological modulation of kinase activity.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Chlorocebus aethiops; Colforsin; COS Cells; Cyclic AMP-Dependent Protein Kinases; HeLa Cells; Humans; Immunoprecipitation; Isoquinolines; Mass Spectrometry; Phosphorylation; Protein Binding; Proteomics; rho-Associated Kinases; Sulfonamides | 2015 |
Developmental Competence of Vitrified-Warmed Bovine Oocytes at the Germinal-Vesicle Stage is Improved by Cyclic Adenosine Monophosphate Modulators during In Vitro Maturation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Colforsin; Cryopreservation; Cyclic AMP; Female; Fertilization in Vitro; In Vitro Oocyte Maturation Techniques; Oocytes; Vitrification | 2015 |
Physiological characterization of the human EndoC-βH1 β-cell line.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Diphosphate; Adenosine Triphosphate; Biological Transport; Calcium Channels; Cell Line; Colforsin; Founder Effect; Gene Expression; Glucokinase; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 2; Glutamine; Glyburide; Humans; Insulin; Insulin-Secreting Cells; Keto Acids; Leucine; Mannoheptulose; Phosphorylation; Potassium Channels, Inwardly Rectifying | 2015 |
Transcriptomic analysis of cyclic AMP response in bovine cumulus cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cattle; Cells, Cultured; Colforsin; Cumulus Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipyridamole; Female; Gene Expression Regulation; In Vitro Oocyte Maturation Techniques; Reproducibility of Results; Signal Transduction | 2015 |
Mechanosensitive activation of CFTR by increased cell volume and hydrostatic pressure but not shear stress.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Size; Chlorides; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelium; Female; Glycine; Humans; Hydrazines; Hydrostatic Pressure; Ion Channel Gating; Lung; Membrane Potentials; Mutation; Oocytes; Patch-Clamp Techniques; Shear Strength; Stress, Mechanical; Xenopus laevis | 2015 |
Involvement of intracellular cAMP in epirubicin-induced vascular endothelial cell injury.
Topics: 1-Methyl-3-isobutylxanthine; Albuterol, Ipratropium Drug Combination; Animals; Apoptosis; Bucladesine; Caspase 3; Caspase 7; Cell Survival; Cells, Cultured; Colforsin; Cyclic AMP; Endothelial Cells; Epirubicin; Lipid Peroxidation; Lipid Peroxides; Swine | 2016 |
Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Buthionine Sulfoximine; Carbenoxolone; Cattle; Colforsin; Cumulus Cells; Cyclic AMP; Ectogenesis; Enzyme Activators; Enzyme Inhibitors; Female; Fertilization in Vitro; Gap Junctions; Glutamate-Cysteine Ligase; Glutathione; Hydrogen Peroxide; In Vitro Oocyte Maturation Techniques; Oocytes; Oxidative Stress; Phosphodiesterase Inhibitors | 2016 |
The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.
Topics: 1-Methyl-3-isobutylxanthine; Adjuvants, Immunologic; Animals; Colforsin; Cyclic AMP; Cyclooxygenase Inhibitors; Female; Green Fluorescent Proteins; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Transgenic; Niflumic Acid; Odorants; Olfactory Marker Protein; Olfactory Mucosa; Olfactory Receptor Neurons; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Signal Transduction | 2016 |
Vagotomy diminishes obesity in cafeteria rats by decreasing cholinergic potentiation of insulin release.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Body Weight; Carbachol; Colforsin; Cyclic AMP; Diet, High-Fat; Disease Models, Animal; Glucose; Hyperglycemia; Hyperinsulinism; Hypertriglyceridemia; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Male; Obesity; Rats; Rats, Wistar; Tissue Culture Techniques; Vagotomy; Vagus Nerve | 2016 |
Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes, Beige; Adipocytes, Brown; Carbazoles; Cell Differentiation; Colforsin; Culture Media; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Gene Expression Regulation; Humans; Indomethacin; Insulin; Mesenchymal Stem Cells; Mitochondria; Primary Cell Culture; Pyrroles; RNA, Small Interfering; Triiodothyronine | 2016 |
Dendritic diameter influences the rate and magnitude of hippocampal cAMP and PKA transients during β-adrenergic receptor activation.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dendrites; Hippocampus; Isoproterenol; Mice; Models, Neurological; Phosphodiesterase Inhibitors; Phosphorylation; Receptors, Adrenergic, beta; Signal Transduction | 2017 |
δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Membrane; Chymotrypsin; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Sodium Channels; Female; Humans; Ion Channel Gating; Oocytes; Probability; Protein Subunits; Proteolysis; Rats; Xenopus laevis | 2017 |
Glycogen metabolism in the glucose-sensing and supply-driven β-cell.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Colforsin; Extracellular Space; Glucose; Glycogen; Glycogen Synthase; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells | 2016 |
Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Aging; Animals; Cardiotonic Agents; Cells, Cultured; Colforsin; Cyclic AMP; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Sinoatrial Node | 2017 |
Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Adenylyl Cyclases; Adult; Animals; Colforsin; Connexins; Cyclic AMP; Energy Metabolism; Erythrocytes; Exercise Tolerance; Female; Genotype; Gluconates; Hemolysis; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Skeletal; Nerve Tissue Proteins; Phenotype; Second Messenger Systems; Time Factors; Young Adult | 2017 |
Atrazine suppresses FSH-induced steroidogenesis and LH-dependent expression of ovulatory genes through PDE-cAMP signaling pathway in human cumulus granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Atrazine; Cell Survival; Colforsin; Cumulus Cells; Cyclic AMP; Estradiol; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Humans; Luteinizing Hormone; Ovulation; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Progesterone; RNA, Messenger; Rolipram; Signal Transduction; Steroids | 2018 |
Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Colforsin; Enteroendocrine Cells; Glucagon-Like Peptide 1; Membrane Potentials; Mice; Nifedipine; omega-Conotoxin GVIA; Optogenetics; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rhodopsin; Sodium Channel Blockers; Tetrodotoxin; Vasodilator Agents | 2017 |
Dynamics of Insulin Secretion from EndoC-
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Cell Line; Colforsin; Exocytosis; Glucose; Glyburide; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mannoheptulose; Signal Transduction | 2017 |
Treatment with cyclic adenosine monophosphate modulators prior to in vitro maturation alters the lipid composition and transcript profile of bovine cumulus-oocyte complexes and blastocysts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Cattle; Colforsin; Cumulus Cells; Cyclic AMP; Embryonic Development; Female; In Vitro Oocyte Maturation Techniques; Lipid Metabolism; Oocytes; Pregnancy; RNA, Messenger; Transcriptome | 2018 |
Fsk and IBMX inhibit proliferation and proapoptotic of glioma stem cells via activation of cAMP signaling pathway.
Topics: 1-Methyl-3-isobutylxanthine; Apoptosis; Brain Neoplasms; Butadienes; Cell Line, Tumor; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Glioma; Humans; Mitogen-Activated Protein Kinases; Neoplastic Stem Cells; Nitriles; Plant Extracts; Plant Roots; Plectranthus; Signal Transduction | 2019 |
Simulated physiological oocyte maturation has side effects on bovine oocytes and embryos.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Cattle; Colforsin; Cumulus Cells; Embryonic Development; Female; Fertilization in Vitro; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Oogenesis; Ovarian Follicle; Pregnancy; Ribosomes | 2019 |
Forskolin and IBMX Induce Neural Transdifferentiation of MSCs Through Downregulation of the NRSF.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cell Transdifferentiation; Cells, Cultured; Colforsin; Down-Regulation; Female; Mesenchymal Stem Cells; Neural Stem Cells; Neurons; Rats; Rats, Sprague-Dawley; Repressor Proteins | 2019 |
Mitochondrial function in immature bovine oocytes is improved by an increase of cellular cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Cattle; Cell Differentiation; Colforsin; Cyclic AMP; Fatty Acids; Female; Gene Expression Regulation; Glucose Transport Proteins, Facilitative; Glycolysis; Granulosa Cells; Meiosis; Methyltransferases; Mitochondria; Oocytes; Oxidation-Reduction; Transcriptome | 2019 |
Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cells, Cultured; Colforsin; Cyclic AMP; Female; Gene Expression Regulation; Granulosa Cells; Humans; Inhibitor of Differentiation Proteins; Ligands; MAP Kinase Signaling System; RNA, Messenger; Signal Transduction; Smad Proteins | 2019 |
Participation of the adenosine salvage pathway and cyclic AMP modulation in oocyte energy metabolism.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Bucladesine; Coculture Techniques; Colforsin; Cumulus Cells; Cyclic AMP; Energy Metabolism; Female; Gap Junctions; Gene Expression; In Vitro Oocyte Maturation Techniques; Meiosis; Mice; Oocytes | 2019 |
Combined use of dbcAMP and IBMX minimizes the damage induced by a long-term artificial meiotic arrest in mouse germinal vesicle oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Apoptosis; Bucladesine; Cell Nucleus; Cells, Cultured; Colforsin; Cyclic AMP; DNA Breaks; Embryonic Development; Female; Meiosis; Mice; Mice, Inbred ICR; Oocytes; Phosphodiesterase Inhibitors | 2020 |
Transcriptional profiling indicates cAMP-driven reversal of HIV latency in monocytes occurs via transcription factor SP-1.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Gene Expression Profiling; Gene Regulatory Networks; Genome, Viral; HIV-1; Host Microbial Interactions; Humans; Jurkat Cells; Models, Biological; Monocytes; Phosphodiesterase Inhibitors; Sp1 Transcription Factor; U937 Cells; Virus Activation; Virus Latency | 2020 |
cAMP signaling primes lung endothelial cells to activate caspase-1 during
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Alprostadil; Animals; Caspase 1; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic GMP; Dinoprostone; Endothelial Cells; Gene Expression Regulation; Host-Pathogen Interactions; Inflammasomes; Interleukin-1beta; Lung; Primary Cell Culture; Pseudomonas aeruginosa; Rats; Rolipram; Signal Transduction; Single-Cell Analysis | 2020 |
Conditions to optimise the developmental competence of immature equine oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastocyst; Colforsin; Embryonic Development; Female; Fertilization in Vitro; Horses; In Vitro Oocyte Maturation Techniques; Oocytes; Sperm Injections, Intracytoplasmic | 2020 |
Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495.
Topics: 1-Methyl-3-isobutylxanthine; AMP-Activated Protein Kinases; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Serine; Vascular Endothelial Growth Factor A | 2020 |
Prostaglandin E2 stimulates cAMP signaling and resensitizes human leukemia cells to glucocorticoid-induced cell death.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Child; Chromogranins; Colforsin; Cyclic AMP; Dexamethasone; Dinoprostone; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Leukemic; GTP-Binding Protein alpha Subunits, Gs; Humans; Male; Mice; Models, Animal; Molecular Targeted Therapy; Neoplasm Proteins; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Radiation Chimera; Receptors, Glucocorticoid; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; RNA, Small Interfering; Second Messenger Systems; Xenograft Model Antitumor Assays | 2021 |
cAMP triggers Na
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Animals, Genetically Modified; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Epithelium; Ion Transport; Male; Sodium; Swine | 2021 |
Effects of cyclic adenosine monophosphate modulating agents during oocyte pre-maturation and the role of melatonin on in vitro maturation of bovine cumulus-oocyte complexes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Monophosphate; Animals; Cattle; Colforsin; Cumulus Cells; Cyclic AMP; Female; In Vitro Oocyte Maturation Techniques; Melatonin; Natriuretic Peptide, C-Type; Oocytes; RNA, Messenger; Superoxide Dismutase | 2023 |