1-methyl-3-isobutylxanthine and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid

1-methyl-3-isobutylxanthine has been researched along with 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (13.33)	18.7374
1990's	14 (46.67)	18.2507
2000's	8 (26.67)	29.6817
2010's	4 (13.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Maxwell, MR; McAteer, JA; Tanner, GA	1
Beauwens, R; Mitchell, PP; Palmisano, J; Steinmetz, PR; Stetson, DL	1
Daugirdas, JT; Fiscus, RR; Islam, S; Kim, DD; Nutting, C; Swanson, V; Wang, XA	1
Machen, TE; Paradiso, AM; Townsley, MC; Wenzl, E	1
Case, RM; Proffitt, R	1
Steinberg, RH; Ueda, Y	1
Collier, ML; Hume, JR	1
Husted, RF; Sigmund, RD; Stokes, JB; Volk, KA	1
Drumm, ML; Harvey, RD; Overholt, JL; Saulino, A	1
Alvaro, D; Boyer, JL; Cho, W; Mennone, A	1
Berton, G; Cabrini, G; Dechecchi, MC; Tamanini, A	1
Grune, S; Jameson, HL; Myers, NC; Sawkat-Anwer, M	1
Halestrap, AP; Levi, AJ; Wang, X	1
Marunaka, Y; Niisato, N	1
Blank, U; Clauss, W; Lindemann, H; Möller, K; Münker, G; Rieboldt, J; Rückes, C; Weber, WM	1
Diecke, FP; Fischbarg, J; Kang, F; Kuang, K; Zhu, Z	1
Larsen, EH; Sørensen, JB	1
Alfonso, A; Botana, LM; Botana, MA; Vieytes, MR	1
Starodub, AM; Wood, JD	1
Faelli, A; Gastaldi, G; Orsenigo, MN; Tosco, M	1
Becq, F; Bulteau, L; Dérand, R; Dormer, RL; Folli, C; Galietta, LJ; Joffre, M; Jougla, C; McNeilly, CM; Métayé, T; Mettey, Y; Morris, MR; Pereira, MM; Vierfond, JM; Zegarra-Moran, O	1
Buchheit, S; Godley, BF; Hellmich, HL; Mo, L; Wang, T; Weng, T; Wills, NK; Yu, A	1
Ache, BW; Doolin, RE	1
Choi, JY; Kim, JL; Kim, SH; Lee, JH; Park, HY; Son, EJ; Song, MH; Yoon, JH	1
Oja, SS; Saransaari, P	1
Chen, MH; Du, JY; Ruan, YC; Wu, ZL; Xiang, H; Yang, ZH; Zhou, WL; Zuo, WL	1
Berger, J; Clauss, WG; Fronius, M; Richter, K	1
Kongsuphol, P; Kraidith, K; Kunzelmann, K; Schreiber, R	1
Ding, C; Lu, M	1
Buck, J; Choi, HB; Gordon, GR; Levin, LR; MacVicar, BA; Martinez, J; McLarnon, JG; Milner, TA; Rungta, RL; Ryu, JK; Tai, C; Tresguerres, M; Zhou, N	1

Other Studies

30 other study(ies) available for 1-methyl-3-isobutylxanthine and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid

Article	Year
Fluid transport in a cultured cell model of kidney epithelial cyst enlargement. Journal of the American Society of Nephrology : JASN, 1992, Volume: 2, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Amiloride; Animals; Bicarbonates; Biological Transport; Bucladesine; Bumetanide; Cell Division; Cells, Cultured; Chlorides; Chlorothiazide; Culture Techniques; Dogs; Intracellular Fluid; Kidney; Kidney Diseases, Cystic; Mice; Ouabain; Solutions	1992
A double-membrane model for urinary bicarbonate secretion. The American journal of physiology, 1985, Volume: 249, Issue:4 Pt 2 Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anthracenes; Bicarbonates; Biological Transport; Biological Transport, Active; Cell Membrane Permeability; Cyclic AMP; Hydrogen-Ion Concentration; Ion Channels; Models, Biological; Turtles; Urinary Bladder	1985
Acetate causes endothelium-independent increases in cyclic AMP in rat caudal artery. The American journal of physiology, 1988, Volume: 255, Issue:6 Pt 2 Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetates; Animals; Arginine Vasopressin; Arteries; Cyclic AMP; Endothelium, Vascular; Guanosine Monophosphate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Reference Values; Tail; Theophylline	1988
Regulation of intracellular pH in resting and in stimulated parietal cells. The American journal of physiology, 1989, Volume: 257, Issue:3 Pt 1 Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphatases; Amiloride; Animals; Carrier Proteins; Chloride-Bicarbonate Antiporters; H(+)-K(+)-Exchanging ATPase; Histamine; Hydrogen; Hydrogen-Ion Concentration; Male; Omeprazole; Parietal Cells, Gastric; Rabbits; Sodium-Hydrogen Exchangers; Stimulation, Chemical	1989
Vanadate stimulates rat pancreatic enzyme secretion through the release of calcium from an intracellular store. Cell calcium, 1984, Volume: 5, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylcholine; Adenylyl Cyclases; Animals; Calcium; Calmodulin; Hydrogen-Ion Concentration; Ouabain; Pancreas; Potassium; Rats; Rats, Inbred Strains; Sodium; Vanadates; Vanadium	1984
Chloride currents in freshly isolated rat retinal pigment epithelial cells. Experimental eye research, 1994, Volume: 58, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; In Vitro Techniques; Ion Channels; Ionomycin; Membrane Potentials; Osmolar Concentration; Pigment Epithelium of Eye; Rats; Rats, Inbred Strains; Thionucleotides	1994
Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes. Circulation research, 1995, Volume: 76, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Alkaloids; Animals; Chloride Channels; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Guinea Pigs; Myocardium; Phorbol 12,13-Dibutyrate; Protein Kinase C; Staurosporine; Ventricular Function	1995
Anion secretion by the inner medullary collecting duct. Evidence for involvement of the cystic fibrosis transmembrane conductance regulator. The Journal of clinical investigation, 1995, Volume: 95, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Analysis of Variance; Animals; Anions; Base Sequence; Bicarbonates; Bumetanide; Cells, Cultured; Chloride Channels; Chlorides; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; DNA Primers; Epithelium; Female; Glyburide; Glycolates; Kidney Medulla; Kidney Tubules, Collecting; Kinetics; Membrane Proteins; Molecular Sequence Data; Nitrobenzoates; Ouabain; Patch-Clamp Techniques; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Rats, Wistar	1995
Rectification of whole cell cystic fibrosis transmembrane conductance regulator chloride current. The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 1 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Anions; Cell Line; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Epithelium; Guinea Pigs; Heart; Membrane Proteins; Phosphorylation; Transfection	1995
Isolation of small polarized bile duct units. Proceedings of the National Academy of Sciences of the United States of America, 1995, Jul-03, Volume: 92, Issue:14 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicarbonates; Bile Ducts; Bucladesine; Chlorides; Cholestasis; Colforsin; Fluoresceins; Gluconates; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Microscopy, Electron; Microscopy, Video; Rats; Rats, Sprague-Dawley; Secretin; Time Factors	1995
Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene. The Journal of biological chemistry, 1993, May-25, Volume: 268, Issue:15 Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Chloride Channels; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Ion Channels; Kinetics; Membrane Proteins; Mice; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Transfection	1993
cGMP stimulates bile acid-independent bile formation and biliary bicarbonate excretion. The American journal of physiology, 1996, Volume: 270, Issue:3 Pt 1 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Arginine Vasopressin; Bicarbonates; Bile; Bile Acids and Salts; Calcium; Cells, Cultured; Choline; Cyclic AMP; Cyclic GMP; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Liver; Male; Oxygen Consumption; Rats; Rats, Wistar; Taurocholic Acid; Thionucleotides; Ursodeoxycholic Acid	1996
Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells. The American journal of physiology, 1996, Volume: 270, Issue:2 Pt 2 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Carrier Proteins; Cell Separation; Cinnamates; Coumaric Acids; Fluoresceins; Fluorescent Dyes; Isomerism; Lactic Acid; Monocarboxylic Acid Transporters; Myocardium; Rats; Stilbenes; Substrate Specificity	1996
Cross talk of bumetanide-sensitive and HCO3--dependent transporters activated by IBMX in renal epithelial A6 cells. The Journal of membrane biology, 1997, May-01, Volume: 157, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Antiporters; Bicarbonates; Bumetanide; Cell Line; Chloride-Bicarbonate Antiporters; Chlorides; Cyclic AMP; Diuretics; Epithelium; Ion Transport; Kidney; Phosphodiesterase Inhibitors; Xenopus laevis	1997
Amiloride-sensitive Na+ channels in human nasal epithelium are different from classical epithelial Na+ channels. Biochemical and biophysical research communications, 1997, Aug-28, Volume: 237, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Humans; Kinetics; Nasal Mucosa; ortho-Aminobenzoates; Quaternary Ammonium Compounds; Reference Values; Sodium Channels	1997
Sodium, potassium, two chloride cotransport in corneal endothelium: characterization and possible role in volume regulation and fluid transport. Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Bumetanide; Carrier Proteins; Cattle; Cell Size; Cells, Cultured; Chlorides; Colforsin; Dose-Response Relationship, Drug; Endothelium, Corneal; Enzyme Inhibitors; Membrane Proteins; Ouabain; Potassium; Sodium; Sodium-Potassium-Chloride Symporters; Tetradecanoylphorbol Acetate	1998
Patch clamp on the luminal membrane of exocrine gland acini from frog skin (Rana esculenta) reveals the presence of cystic fibrosis transmembrane conductance regulator-like Cl- channels activated by cyclic AMP. The Journal of general physiology, 1998, Volume: 112, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Bucladesine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Diphenylamine; Exocrine Glands; Glyburide; Hypoglycemic Agents; Ion Channel Gating; Nitrobenzoates; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rana esculenta; Skin	1998
Sodium, PMA and calcium play an important role on intracellular pH modulation in rat mast cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 1998, Volume: 8, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Cyclic AMP; Enzyme Inhibitors; Hydrogen-Ion Concentration; Ion Transport; Mast Cells; Ouabain; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Thapsigargin	1998
Histamine H(2) receptor activated chloride conductance in myenteric neurons from guinea pig small intestine. Journal of neurophysiology, 2000, Volume: 83, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine; Animals; Calcium Channel Blockers; Chlorides; Cyclic AMP; Cyclooxygenase Inhibitors; Electric Conductivity; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guinea Pigs; Histamine; Intestine, Small; Membrane Potentials; Myenteric Plexus; Neurons; Niflumic Acid; omega-Conotoxins; Paracrine Communication; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Receptors, Histamine H2; Stress, Psychological; Theophylline; Thionucleotides	2000
An endogenous monocarboxylate transport in Xenopus laevis oocytes. American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 278, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; 4-Chloromercuribenzenesulfonate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Cations; Chlorine; Coumaric Acids; Female; Hydrogen-Ion Concentration; Lactic Acid; Oocytes; Pyruvic Acid; Radioisotopes; Sodium; Tetraethylammonium; Xenopus laevis	2000
Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells. American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Caffeine; Calcium Channel Blockers; Chlorides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Iodides; Iodine Radioisotopes; Membrane Potentials; Membrane Proteins; ortho-Aminobenzoates; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphorylation; Respiratory Mucosa; Theophylline; Xanthines	2000
Chloride channel expression in cultured human fetal RPE cells: response to oxidative stress. Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:13 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amino Acid Sequence; Base Sequence; Blotting, Western; Cell Line, Transformed; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; DNA, Complementary; Fetus; Humans; Hydrogen Peroxide; Membrane Potentials; Molecular Sequence Data; Oxidative Stress; Patch-Clamp Techniques; Pigment Epithelium of Eye; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2000
Cyclic nucleotide signaling mediates an odorant-suppressible chloride conductance in lobster olfactory receptor neurons. Chemical senses, 2005, Volume: 30, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Anthracenes; Chloride Channels; Colforsin; Cyclic AMP; Electric Stimulation; Flufenamic Acid; Imines; Nucleotides, Cyclic; Olfactory Receptor Neurons; Palinuridae; Signal Transduction	2005
ENaC- and CFTR-dependent ion and fluid transport in human middle ear epithelial cells. Hearing research, 2006, Volume: 211, Issue:1-2 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Amiloride; Cells, Cultured; Chloride Channels; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Ear, Middle; Epithelial Cells; Epithelial Sodium Channels; Humans; Ion Transport; Nasal Mucosa; Sodium Channels; Water-Electrolyte Balance	2006
Characteristics of taurine release in slices from adult and developing mouse brain stem. Amino acids, 2006, Volume: 31, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Alloxan; Animals; Brain Stem; Genistein; Ion Channels; Mice; Organ Culture Techniques; Potassium; Quinacrine; Riluzole; Taurine; Time Factors	2006
Cellular mechanisms of carbachol-stimulated Cl- secretion in rat epididymal epithelium. Biology of reproduction, 2006, Volume: 75, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Carbachol; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Epididymis; Epithelial Cells; Epithelium; Imines; Male; Muscarinic Agonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Signal Transduction	2006
Evidence for basolateral Cl- channels as modulators of apical Cl- secretion in pulmonary epithelia of Xenopus laevis. American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 300, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Cell Polarity; Chloride Channels; Chloride-Bicarbonate Antiporters; Chlorides; Colforsin; Epithelial Cells; Female; In Vitro Techniques; Lung; Membrane Potentials; Nitrobenzoates; Nystatin; ortho-Aminobenzoates; Permeability; Time Factors; Xenopus laevis	2011
CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca²⁺-activated Cl⁻ conductance. Pflugers Archiv : European journal of physiology, 2011, Volume: 462, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Chloride Channels; Colforsin; Cyclooxygenase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Genistein; HEK293 Cells; Humans; Ion Channel Gating; Niflumic Acid; Oocytes; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Protons; Xenopus laevis	2011
CFTR-mediated Cl(-) transport in the acinar and duct cells of rabbit lacrimal gland. Current eye research, 2012, Volume: 37, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acinar Cells; Animals; Benzoates; Biological Transport; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Female; Fluorescent Dyes; Lacrimal Apparatus; Microscopy, Confocal; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rabbits; Thiazolidines	2012
Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron, 2012, Sep-20, Volume: 75, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenylyl Cyclases; Animals; Animals, Newborn; Astrocytes; Bicarbonates; Coumaric Acids; Cyclic AMP; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Glial Fibrillary Acidic Protein; Glucose; Glycogen; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Lactic Acid; Microscopy, Immunoelectron; Microtubule-Associated Proteins; Models, Biological; Monocarboxylic Acid Transporters; Neurons; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin	2012