1-methyl-3-isobutylxanthine has been researched along with 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone in 102 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (57.84) | 18.7374 |
| 1990's | 31 (30.39) | 18.2507 |
| 2000's | 9 (8.82) | 29.6817 |
| 2010's | 3 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bristol, JA; Cain, MH; Weishaar, RE | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Hamprecht, B; Moroder, L; Propst, F; Wünsch, E | 1 |
| Glass, WF; Moore, JB | 1 |
| Boeynaems, JM; Mockel, J; Rocmans, P; Unger, J; Van Herle, A; Van Sande, J | 1 |
| Lehnert, S | 1 |
| Geller, HM | 1 |
| Endoh, M; Katano, Y | 2 |
| Baidan, LV; Fertel, RH; Wood, JD | 1 |
| Ashikaga, T; Kishi, Y; Numano, F | 1 |
| Kather, H | 1 |
| Devall, LJ; Klinkefus, BA; Kobylarz-Singer, D; Kuipers, PJ; Weishaar, RE; Wright, CD | 1 |
| Chabardès, D; Montégut, M; Siaume-Perez, S; Zhou, Y | 1 |
| Schwarzschild, MA; Zigmond, RE | 1 |
| Hattori, R; Kawai, C; Shirotani, M; Yui, Y | 1 |
| Hanafusa, T; Kitajima, K; Mashita, K; Matsui, I; Miyagawa, J; Mori-Tanaka, M; Oda, Y; Tajima, K; Tarui, S | 2 |
| Avendano, G; Gan, J; Iuvone, PM | 1 |
| Nicholson, D; Reid, A; Sawynok, J | 1 |
| Nicholson, D; Sawynok, J; White, TD | 1 |
| Brooker, G; DeBernardi, MA; Seki, T | 1 |
| Cochaux, P; Dumont, JE; Van Sande, J | 1 |
| Dohi, T; Kitayama, S; Morita, K; Tsujimoto, A | 1 |
| Elks, ML; Manganiello, VC | 2 |
| Alberts, P; Ogren, VR; Sellström, AI | 1 |
| Conti, M; Geremia, R; Monaco, L; Stefanini, M | 1 |
| Gabbay, RA; Lardy, HA | 2 |
| Kelly, KJ; Rayfield, EJ | 1 |
| Eckhardt, L; Imamura, K; Kimura, T; Schulz, I | 1 |
| Madison, DV; Nicoll, RA | 1 |
| Gardner, JD; Jensen, RT; Jones, SW; Noguchi, M; Villanueva, ML; Zhou, ZC | 1 |
| Malemud, CJ; Mills, TM; Papay, RS; Shuckett, R | 1 |
| Hoffman, BB; Lee, CH; Tsujimoto, G | 1 |
| Fredholm, BB; Lerner, U; Ransjö, M | 1 |
| Narahashi, T; Tsunoo, A | 1 |
| Paes de Carvalho, R; Ventura, AL | 1 |
| Bonjour, JP; Rizzoli, R | 1 |
| Madelian, V; Shain, W | 1 |
| Klein, DC; Sugden, D | 1 |
| Cosowsky, L; Raufman, JP | 1 |
| Degerman, E; Elks, M; Manganiello, V | 1 |
| Fredholm, BB; Lerner, UH; Ransjö, M | 1 |
| Aghajanian, GK; Wang, YY | 1 |
| Ahrén, KE; Sender Baum, MG | 1 |
| Kandel, ER; Sweatt, JD | 1 |
| Hougaard, DM; Pedersen, SB; Richelsen, B | 1 |
| Davis, JS; Lahav, M; Rennert, H | 1 |
| Holtzman, SG | 1 |
| Decaux, G; Dumont, JE; Mockel, J; Unger, J | 1 |
| Anand-Srivastava, MB; Johnson, RA | 1 |
| Collier, HO; Cuthbert, NJ; Francis, DL | 1 |
| Dunn, AJ; Villiger, JW | 1 |
| Davis, BB; Mattammal, MB; Rapp, NS; Zenser, TV | 1 |
| Kurz, JB; Perkins, JP | 1 |
| Pellmar, TC | 1 |
| Anand-Srivastava, MB; Johnson, RA; Olaus, TH | 1 |
| Gardner, JD; Korman, LY; Sutliff, VE; Walker, MD | 1 |
| de Mello, FG; Paes de Carvalho, R | 1 |
| Przegaliński, E; Rawłów, A | 1 |
| Wachtel, H | 2 |
| Norman, JA; Staehelin, M | 1 |
| Sass, SP; Sheppard, H; Tsien, WH | 1 |
| Dumont, JE; Erneux, C; Miot, F | 1 |
| Deuel, TF; Keehan, M; Rozengurt, E; Stroobant, P; Waterfield, MD | 1 |
| Gardner, JD; Jensen, RT; Sutliff, VE; Walker, MD | 1 |
| Hidaka, H; Manganiello, VC; Osborne, JC; Vaughan, M; Yamamoto, S; Yamamoto, T | 1 |
| Daniel, JW; Oleinick, NL | 1 |
| Dalaker, K; Prydz, H | 1 |
| Matsui, H; Yamamoto, C | 1 |
| Shechter, Y | 1 |
| Colicelli, J; Kytle, K; Pillai, R; Reyes, A | 1 |
| Buzzi, M; Cavallaro, R; Ferretti, ME; Paradisi, MP; Pareschi, MC; Reali, E; Spisani, S; Torrini, I; Traniello, S; Zecchini, GP | 1 |
| Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M | 1 |
| Chiba, S; Iwatsuki, K; Ren, LM | 1 |
| Brick-Ghannam, C; Chabardès, D; Griffiths, NM; Siaume-Perez, S | 1 |
| Albert, DA; Rozengurt, E | 1 |
| Garmey, JC; Lahav, M; Veldhuis, JD | 1 |
| Liu, J; Marcus, DC; Shen, Z; Sunose, H | 1 |
| Bakre, MM; Visweswariah, SS | 1 |
| Harmon, CS; Nevins, TD | 1 |
| Horita, T; Kasugai, S; Miyamoto, K; Ohya, K; Waki, Y | 1 |
| Brundege, JM; Diao, L; Dunwiddie, TV; Proctor, WR | 1 |
| Carcillo, JA; Dubey, RK; Gillespie, DG; Jackson, EK; Mi, Z | 1 |
| Maurice, DH; Palmer, D; Tsoi, K | 1 |
| Majluf-Cruz, A; Omburo, GA; Zhu, WH | 1 |
| Kawasaki, T; Kobayashi, Y; Nakamura, H; Oki, Y; Shimizu, E; Yoshimi, T | 1 |
| Cederbaum, SD; Ignarro, LJ; Mori, M; Morris, SM; Wei, LH | 1 |
| Giovanni, A; Wirtz-Brugger, F | 1 |
| Cherry, JA; Pho, V; Thompson, BE | 1 |
| Absher, PM; Dunkerley, HA; Jimmo, SL; Maurice, DH; Netherton, SJ; Palmer, D; Raymond, DR; Russell, JC; Sage, EH; Tilley, DG; Vernon, RB | 1 |
| Abzhalelov, BB; Bronnikov, GE; Dolgacheva, LP; Zhang, SJ; Zinchenko, VP | 1 |
| Breese, E; Del Soldato, P; Mitchell, J; Warner, T; Wood, E; Zacharowski, P | 1 |
| Oja, SS; Saransaari, P | 1 |
| Abi-Gerges, A; Conti, M; Fischmeister, R; Heymes, C; Lefebvre, F; Lugnier, C; Mateo, P; Richter, W; Samuel, JL; Vandecasteele, G; Varin, A | 1 |
| Batuca, JR; Monteiro, EC; Nunes, AR | 1 |
| Cheng, D; Gillespie, DG; Jackson, EK; Mi, Z; Ren, J | 1 |
| Kaneda, T; Sasaki, N; Shimizu, K; Urakawa, N | 1 |
1 review(s) available for 1-methyl-3-isobutylxanthine and 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone
| Article | Year |
|---|---|
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity | 1985 |
101 other study(ies) available for 1-methyl-3-isobutylxanthine and 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acids; Cyclic AMP; Diazepam; Glioma; Glucagon; Humans; Hybrid Cells; Neuroblastoma; Neurotransmitter Agents; Peptides; Prostaglandin Endoperoxides, Synthetic; Secretin | 1979 |
Inhibition of human lung cyclic GMP and cyclic AMP phosphodiesterases by certain nucleosides, nucleotides, and pharmacological phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aminophylline; Caffeine; Etazolate; Humans; In Vitro Techniques; Kinetics; Lung; Nucleosides; Nucleotides, Cyclic | 1979 |
In vitro nonbutanol-extractable iodine release in dog thyroid.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bucladesine; Calcimycin; Carbachol; Cholera Toxin; Dogs; Indomethacin; Ouabain; Thyroglobulin; Thyroid Gland; Thyrotropin | 1979 |
Radioprotection of mouse intestine by inhibitors of cyclic AMP phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cell Survival; Jejunum; Male; Mice; Radiation-Protective Agents; Reserpine; Theophylline | 1979 |
Are histamine H2-receptor depressions of neuronal activity in tissue cultures from rat hypothalamus mediated through cyclic adenosine monophosphate?
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Culture Techniques; Cyclic AMP; Hypothalamus; Rats; Receptors, Histamine; Receptors, Histamine H2 | 1979 |
Effects of a cardiotonic quinolinone derivative Y-20487 on the isoproterenol-induced positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: comparison with rolipram, Ro 20-1724, milrinone, and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Milrinone; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Wistar; Rolipram; Stimulation, Chemical; Thiadiazines | 1992 |
Effects of brain-gut related peptides on cAMP levels in myenteric ganglia of guinea-pig small intestine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcitonin Gene-Related Peptide; Cholecystokinin; Cyclic AMP; Dose-Response Relationship, Drug; Ganglia; Gastrin-Releasing Peptide; Guinea Pigs; Intestine, Small; Male; Myenteric Plexus; Peptides; Signal Transduction; Substance P; Vasoactive Intestinal Peptide | 1992 |
Phosphodiesterases in vascular endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Kinetics; Milrinone; Muscle, Smooth, Vascular; Pyridones | 1992 |
Beta-adrenergic stimulation of adenine nucleotide catabolism and purine release in human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Adipose Tissue; Cells, Cultured; Cyclic AMP; Female; Humans; Hypoxanthine; Hypoxanthines; Inosine; Isoproterenol; Kinetics; Lipolysis; Propranolol; Receptors, Adrenergic, beta | 1990 |
Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and beta-adrenoceptor-mediated response in the rat ventricular myocardium.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyclic AMP; Imidazoles; In Vitro Techniques; Isoenzymes; Isoproterenol; Male; Myocardial Contraction; Myocardium; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Theophylline | 1990 |
Differential inhibition of human neutrophil functions. Role of cyclic AMP-specific, cyclic GMP-insensitive phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Humans; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram | 1990 |
Two mechanisms of inhibition by prostaglandin E2 of hormone-dependent cell cAMP in the rat collecting tubule.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Animals; Arginine Vasopressin; Colforsin; Cyclic AMP; Dinoprostone; Indomethacin; Isoproterenol; Kidney Tubules, Collecting; Male; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Signal Transduction; Xanthines | 1990 |
Effects of peptides of the secretin-glucagon family and cyclic nucleotides on tyrosine hydroxylase activity in sympathetic nerve endings.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; Heart Ventricles; Male; Nerve Endings; Nitroprusside; Protein Kinase C; Rats; Rats, Inbred Strains; Second Messenger Systems; Secretin; Sympathetic Nervous System; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1991 |
U-61,431F, a stable prostacyclin analogue, inhibits the proliferation of bovine vascular smooth muscle cells with little antiproliferative effect on endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aorta; Cattle; Cell Division; Cells, Cultured; Cyclic AMP; DNA Replication; Endothelium, Vascular; Epoprostenol; Kinetics; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Prostaglandins, Synthetic; Thymidine; Tritium | 1991 |
Inhibitory effects of ionophore A23187 on the release of thyroid hormone and colloid reabsorption in mouse thyroid glands.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcimycin; Calcium; Colforsin; Colloids; Cyclic AMP; Epithelium; Mice; Mice, Inbred BALB C; Microscopy, Electron; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1991 |
K(+)-evoked depolarization stimulates cyclic AMP accumulation in photoreceptor-enriched retinal cell cultures: role of calcium influx through dihydropyridine-sensitive calcium channels.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cadmium; Cadmium Chloride; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Cobalt; Cyclic AMP; Kinetics; Magnesium Chloride; Membrane Potentials; Nifedipine; Photoreceptor Cells; Potassium; Retina; Retinal Ganglion Cells | 1991 |
Effects of forskolin and phosphodiesterase inhibitors on spinal antinociception by morphine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Colforsin; Cyclic AMP; Injections, Spinal; Male; Morphine; Nociceptors; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord | 1991 |
Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 5'-Nucleotidase; Adenosine; Animals; Colforsin; Cyclic AMP; In Vitro Techniques; Morphine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rolipram; Spinal Cord; Synaptosomes | 1991 |
Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Bradykinin; Calcimycin; Calcium; Cattle; Cell Line; Cholera Toxin; Cyclic AMP; DNA; Glioma; Isoproterenol; Kinetics; Neurokinin A; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; RNA, Messenger; Signal Transduction; Transfection | 1991 |
Alpha 1-adrenergic regulation of thyrotropin-stimulated release of 3, 5, 3' -triiodothyronine and thyroxine from perifused mouse thyroid.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Male; Methoxamine; Mice; Prazosin; Receptors, Adrenergic, alpha; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1991 |
Further characterization of the iodide inhibitory effect on the cyclic AMP system in dog thyroid slices.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine Triphosphate; Alprostadil; Animals; Calcium; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Dogs; Iodides; Iodine Radioisotopes; Methimazole; Prostaglandins E; Protein Biosynthesis; RNA; Thyroid Gland; Thyrotropin; Triiodothyronine | 1985 |
Enhancement of acetylcholine-evoked catecholamine release from perfused dog adrenals by elevating cyclic AMP levels.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adrenal Glands; Animals; Catecholamines; Cholera Toxin; Cyclic AMP; Cyclic GMP; Dogs; Female; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Potassium; Spectrometry, Fluorescence | 1985 |
A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Adipose Tissue; Animals; Azo Compounds; Cell Differentiation; Cell Line; Dexamethasone; Glycerolphosphate Dehydrogenase; Insulin; Lipid Metabolism; Mice; Phenylisopropyladenosine; Quinolines; Quinolones; Solubility; Theophylline; Time Factors | 1985 |
Role of adenosine 3',5'-cyclic monophosphate in adrenoceptor-mediated control of 3H-noradrenaline secretion in guinea-pig ileum myenteric nerve terminals.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Colforsin; Cyclic AMP; Cyclic GMP; Guinea Pigs; Ileum; In Vitro Techniques; Isoproterenol; Male; Myenteric Plexus; Nerve Endings; Nicotinic Acids; Norepinephrine; Phosphodiesterase Inhibitors; Propranolol; Receptors, Adrenergic; Yohimbine | 1985 |
Effect of phosphodiesterase inhibitors on Sertoli cell refractoriness: reversal of the impaired androgen aromatization.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Estrogens; Follicle Stimulating Hormone; Isoproterenol; Male; Phosphodiesterase Inhibitors; Rats; Receptors, Cell Surface; Receptors, FSH; Sertoli Cells | 1986 |
Methylisobutylxanthine blocks insulin antagonism of cAMP-stimulated glycogenolysis at a site distinct from phosphodiesterase. Evidence favoring an insulin-insensitive calcium release mechanism.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Aminoquinolines; Animals; Calcium; Concanavalin A; Cyclic AMP; Glucose; Insulin; Lactates; Lactic Acid; Liver Glycogen; Male; Phenylephrine; Phenylisopropyladenosine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Theophylline; Vasopressins | 1986 |
Virus-induced alterations in cyclic adenosine monophosphate generation in hamster islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cricetinae; Cyclic AMP; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Secretory Rate | 1986 |
Ca2+-, phorbol ester-, and cAMP-stimulated enzyme secretion from permeabilized rat pancreatic acini.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Calcium; Carbachol; Cell Membrane Permeability; Colforsin; Cyclic AMP; Cytoplasmic Granules; Digitonin; Egtazic Acid; Pancreas; Phorbols; Rats; Rats, Inbred Strains; Saponins; Spermine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1986 |
Cyclic adenosine 3',5'-monophosphate mediates beta-receptor actions of noradrenaline in rat hippocampal pyramidal cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Adenine; Adenylyl Cyclase Inhibitors; Animals; Calcium; Colforsin; Cyclic AMP; Guanylyl Imidodiphosphate; Hippocampus; In Vitro Techniques; Isoproterenol; Neurons; Norepinephrine; Potassium; Rats | 1986 |
Mechanism of action of calcitonin gene-related peptide in stimulating pancreatic enzyme secretion.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Guinea Pigs; Male; Nerve Tissue Proteins; Pancreas; Peptide PHI; Peptides; Phosphodiesterase Inhibitors; Secretin; Species Specificity; Theophylline; Vasoactive Intestinal Peptide | 1986 |
Stimulation of sulfated-proteoglycan synthesis by forskolin in monolayer cultures of rabbit articular chondrocytes.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cartilage, Articular; Cells, Cultured; Chemical Phenomena; Chemistry; Chondroitin Sulfate Proteoglycans; Colforsin; Cyclic AMP; Glycosaminoglycans; Proteoglycans; Rabbits; Stimulation, Chemical | 1986 |
Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Aging; Bucladesine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Iodocyanopindolol; Isoproterenol; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Pindolol; Receptors, Adrenergic, beta; Serotonin | 1986 |
Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone and Bones; Bone Resorption; Calcium; Colforsin; Cyclic AMP; Dinoprostone; In Vitro Techniques; Indomethacin; Kinetics; Lysosomes; Mice; Parathyroid Hormone; Prostaglandins E; Pyrrolidinones; Rolipram; Theophylline | 1986 |
Cyclic nucleotide potentiation of muscarinic responses in neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenine; Adenosine; Animals; Bucladesine; Cell Line; Cyclic AMP; Cyclic GMP; Dopamine; Membrane Potentials; Neurons; Receptors, Muscarinic | 1987 |
Development of adenosine-dependent cyclic AMP accumulation in the avian optic tectum.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Deaminase; Animals; Chick Embryo; Cyclic AMP; Dipyridamole; Proteins; Superior Colliculi | 1987 |
Effect of dexamethasone on parathyroid hormone stimulation of cyclic AMP in an opossum kidney cell line.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Kidney; Opossums; Parathyroid Hormone; Phosphoric Diester Hydrolases | 1987 |
Regulation of isoproterenol-induced cyclic AMP accumulation in LRM55 glial cells by phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Cells, Cultured; Cyclic AMP; Isoproterenol; Neuroglia; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases | 1987 |
Activators of protein kinase C act at a postreceptor site to amplify cyclic AMP production in rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic alpha-Agonists; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Enzyme Activation; Female; Phenylephrine; Phorbol Esters; Pineal Gland; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate | 1988 |
Differential actions of phosphodiesterase inhibitors on secretin- and vasoactive intestinal peptide-induced increases in chief cell cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Mucosa; Guinea Pigs; Kinetics; Models, Biological; Phosphodiesterase Inhibitors; Secretin; Theophylline; Vasoactive Intestinal Peptide | 1988 |
Selective inhibitors of specific phosphodiesterases in intact adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipose Tissue; Animals; Cattle; Cells, Cultured; Cyclic GMP; Dexamethasone; Insulin; Kinetics; Liver; Mice; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinolines; Quinolones; Rats; Structure-Activity Relationship | 1988 |
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Bone Resorption; Calcium; Cells, Cultured; Cholera Toxin; Cyclic AMP; Hydrocortisone; Indomethacin; Meclofenamic Acid; Mice; Mice, Inbred Strains; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Skull; Theophylline | 1988 |
Excitation of locus coeruleus neurons by an adenosine 3',5'-cyclic monophosphate-activated inward current: extracellular and intracellular studies in rat brain slices.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Neurons; Rats; Reference Values; Theophylline | 1987 |
Sphingosine and psychosine, suggested inhibitors of protein kinase C, inhibit LH effects in rat luteal cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Brain; Bucladesine; Colforsin; Corpus Luteum; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Female; Luteal Cells; Luteinizing Hormone; Progesterone; Protein Kinase C; Psychosine; Rats; Rats, Inbred Strains; Sphingosine | 1988 |
Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation of Aplysia sensory neurons.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Actins; Animals; Anisomycin; Aplysia; Cyclic AMP; Dactinomycin; Molecular Weight; Neurons, Afferent; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Kinases; Serotonin; Synapses; Thionucleotides; Transcription, Genetic | 1989 |
Characterization of antilipolytic action of polyamines in isolated rat adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipose Tissue; Animals; Cells, Cultured; Cyclic AMP; Lipolysis; Male; Polyamines; Rats; Rats, Inbred Strains; Spermine | 1989 |
Mechanism of the luteolytic action of prostaglandin F-2 alpha in the rat.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium; Corpus Luteum; Cyclic AMP; Dinoprost; Female; Luteinizing Hormone; Luteolysis; Pregnancy; Progesterone; Rats | 1989 |
Phosphodiesterase inhibitors potentiate opiate-antagonist discrimination by morphine-dependent rats.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Body Weight; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Male; Morphine; Naltrexone; Narcotic Antagonists; Papaverine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
In vitro regulation of ornithine decarboxylase in dog thyroid slices.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium; Carboxy-Lyases; Cycloheximide; Dactinomycin; Dogs; In Vitro Techniques; Kinetics; Manganese; Ornithine Decarboxylase; Prostaglandins F; Puromycin; Thyroid Gland; Thyrotropin | 1980 |
Regulation of adenosine-sensitive adenylate cyclase from rat brain striatum.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenylyl Cyclases; Animals; Corpus Striatum; Guanosine Triphosphate; Kinetics; Magnesium; Male; Manganese; Rabbits | 1980 |
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Humans; Hypoxanthines; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Pyrimidines; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Triazoles; Xanthines | 1981 |
Phosphodiesterase inhibitors facilitate memory for passive avoidance conditioning.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Avoidance Learning; Cyclic AMP; Electroshock; Foot; Imidazoles; Male; Memory; Mice; Mice, Inbred ICR; Phosphodiesterase Inhibitors; Reaction Time; Retention, Psychology; Theophylline | 1981 |
Inhibition of bradykinin stimulation of renal medullary prostaglandin E2 synthesis by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bradykinin; Cyclic AMP; Dinoprostone; FANFT; In Vitro Techniques; Kidney Medulla; Male; Microsomes; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Prostaglandins E; Rabbits; Seminal Vesicles; Sheep | 1981 |
Cystic fibrosis fibroblasts respond normally to isoproterenol.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adolescent; Adult; Cell Division; Cells, Cultured; Child; Child, Preschool; Cyclic AMP; Cystic Fibrosis; Female; Fibroblasts; Humans; Isoproterenol; Male; Phosphodiesterase Inhibitors; Prostaglandins E; Skin | 1981 |
Does cyclic 3' ,5'-adenosine monophosphate act as second messenger in a voltage-dependent response to 5-hydroxytryptamine in Aplysia?
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclase Inhibitors; Animals; Aplysia; Cyclic AMP; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Imidazoles; Membrane Potentials; Neostigmine; Neurons; Serotonin; Theophylline; Tubocurarine | 1981 |
Regulation of hepatocyte cAMP and pyruvate kinase by site-specific analogs of adenosine.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenylyl Cyclases; Animals; Cyclic AMP; Deoxyadenosines; Dideoxyadenosine; Epinephrine; Liver; Male; Phenylisopropyladenosine; Pyruvate Kinase; Rats; Rats, Inbred Strains | 1982 |
Effects of inhibitors of cyclic nucleotide phosphodiesterase on the actions of vasoactive intestinal peptide and secretin on pancreatic acini.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Gastrointestinal Hormones; Guinea Pigs; Male; Pancreas; Secretin; Theophylline; Vasoactive Intestinal Peptide | 1982 |
Adenosine-elicited accumulation of adenosine 3', 5'-cyclic monophosphate in the chick embryo retina.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Animals; Cells, Cultured; Chick Embryo; Cyclic AMP; Dopamine Antagonists; Retina | 1982 |
The stimulatory action of phosphodiesterase inhibitors on the flexor reflex of the hind limb in the spinal rat.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Drug Interactions; Male; Phenoxybenzamine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Reflex; Rolipram; Spinal Cord; Theophylline | 1982 |
Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3', 5'-monophosphate phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Behavior, Animal; Body Temperature; Bucladesine; Imidazoles; Male; Motor Activity; Pyrimidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram | 1982 |
Calmodulin inhibitors activate glycogen phosphorylase B to A conversion in C6 glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Antipsychotic Agents; Calcimycin; Calcium; Calcium-Binding Proteins; Calmodulin; Cells, Cultured; Cyclic AMP; Enzyme Activation; Glioma; Phosphodiesterase Inhibitors; Phosphorylases; Rats | 1982 |
The lack of correlation between inhibition of aggregation and cAMP levels with canine platelets.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Animals; Arachidonic Acids; Cyclic AMP; Depression, Chemical; Dogs; Epinephrine; Female; Male; Papaverine; Phosphodiesterase Inhibitors; Platelet Aggregation; Prostaglandins E; Theophylline | 1982 |
The involvement of a calmodulin-dependent phosphodiesterase in the negative control of carbamylcholine on cyclic AMP levels in dog thyroid slices.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcium-Binding Proteins; Calmodulin; Carbachol; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Dogs; In Vitro Techniques; Kinetics; Thyroid Gland | 1983 |
Species differences in behavioural effects of rolipram and other adenosine cyclic 3H, 5H-monophosphate phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Behavior, Animal; Body Temperature Regulation; Cyclic AMP; Dose-Response Relationship, Drug; Grooming; Guinea Pigs; Male; Motor Activity; Muridae; Muscle Contraction; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Inbred Strains; Rolipram; Species Specificity | 1983 |
Platelet-derived growth factor elicits cyclic AMP accumulation in Swiss 3T3 cells: role of prostaglandin production.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cell Division; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Growth Substances; Indomethacin; Mice; Peptides; Platelet-Derived Growth Factor; Prostaglandins E | 1983 |
Effects of inhibitors of cyclic nucleotide phosphodiesterase on actions of cholecystokinin, bombesin, and carbachol on pancreatic acini.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Bombesin; Carbachol; Cyclic AMP; Guinea Pigs; Imidazoles; In Vitro Techniques; Pancreas; Peptides; Sincalide; Theophylline | 1983 |
Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Dipyridamole; Hydrolysis; Kinetics; Liver; Papaverine; Quinolines; Quinolones; Theophylline | 1983 |
Cyclic nucleotide responses and radiation-induced mitotic delay in Physarum polycephalum.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Caffeine; Cobalt Radioisotopes; Cyclic AMP; Cyclic GMP; Gamma Rays; Mitosis; Phosphodiesterase Inhibitors; Physarum; Theophylline; Time Factors | 1984 |
Regulation of thromboplastin synthesis in mouse placental cells in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Depression, Chemical; Dinoprostone; Diterpenes; Epinephrine; Female; In Vitro Techniques; Mice; Placenta; Pregnancy; Prostaglandins E; Stimulation, Chemical; Thromboplastin | 1983 |
The possible involvement of adenylate cyclase inhibition in the field potential suppression through alpha-2 adrenergic receptors in the bed nucleus of the stria terminalis.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenylyl Cyclase Inhibitors; Animals; Bucladesine; Deoxyadenosines; Diencephalon; Drug Interactions; Electrophysiology; Guinea Pigs; Norepinephrine; Receptors, Adrenergic, alpha; Thionucleosides | 1984 |
Site of insulin inhibition of cAMP-stimulated glycogenolysis.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; In Vitro Techniques; Insulin; Kinetics; Liver; Liver Glycogen; Rats | 1984 |
Selective effects of phosphodiesterase inhibitors on different phosphodiesterases, adenosine 3',5'-monophosphate metabolism, and lipolysis in 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipose Tissue; Animals; Cell Line; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Kinetics; Lipolysis; Mice; Phosphodiesterase Inhibitors; Quinolines; Quinolones | 1984 |
Differential effects of two phosphodiesterase inhibitors on fat cell metabolism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipose Tissue; Animals; Cholera Toxin; Cyclic AMP; Imidazoles; In Vitro Techniques; Insulin; Kinetics; Lipolysis; Male; Rats; Rats, Inbred Strains; Theophylline | 1984 |
Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Base Sequence; Cloning, Molecular; DNA Primers; Drug Resistance; Kinetics; Mammals; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Point Mutation; Polymerase Chain Reaction; Pyrrolidinones; Rats; Recombinant Proteins; Rolipram | 1993 |
Two new formylated peptides able to activate chemotaxis and respiratory burst selectively as tools for studying human neutrophil responses.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Cell Movement; Chemotaxis, Leukocyte; Cyclic AMP; Esters; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Respiratory Burst; Superoxides | 1994 |
[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cell Line; Cell Membrane; Cyclic AMP; Cytosol; Glioma; Kinetics; Mice; Neuroblastoma; Neuroglia; Neurons; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rats; Rolipram; Tritium; Tumor Cells, Cultured | 1994 |
Effects of cyclic nucleotide phosphodiesterase IV inhibitor, Ro20,1724, on pancreatic exocrine secretion in dog.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amrinone; Analysis of Variance; Animals; Bicarbonates; Cyclic AMP; Cyclic GMP; Dogs; Drug Interactions; Female; Injections, Intra-Arterial; Male; Pancreatic Juice; Phosphodiesterase Inhibitors; Proteins; Secretin; Sincalide; Trifluoperazine | 1994 |
Effect of prostaglandin E2 on agonist-stimulated cAMP accumulation in the distal convoluted tubule isolated from the rabbit kidney.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Calcitonin; Cyclic AMP; Dinoprostone; Isoproterenol; Kidney Tubules, Distal; Male; Parathyroid Hormone; Rabbits; Vasoactive Intestinal Peptide | 1993 |
Opposite effects of cyclic AMP on the expression of the genes encoding ribonucleotide reductase in Swiss 3T3 and RAT 1 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Cycle; Cell Division; Cell Line; Colforsin; Cyclic AMP; DNA; Gene Expression Regulation, Enzymologic; Insulin; Mice; Rats; Ribonucleotide Reductases | 1993 |
Paradoxical effect of 3-isobutyl-1-methylxanthine on cytochrome P450 cholesterol side-chain cleavage mRNA accumulation in porcine granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Cyclic AMP; Female; Follicle Stimulating Hormone; Granulosa Cells; Progesterone; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate | 1996 |
cAMP increases apical IsK channel current and K+ secretion in vestibular dark cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bucladesine; Cell Membrane; Cyclic AMP; Cytosol; Electric Conductivity; Epithelial Cells; Epithelium; Gerbillinae; In Vitro Techniques; Nystatin; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Vestibule, Labyrinth | 1997 |
Dual regulation of heat-stable enterotoxin-mediated cGMP accumulation in T84 cells by receptor desensitization and increased phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bacterial Toxins; Cell Line; Cell Membrane; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Guanylate Cyclase; Humans; Kinetics; Milrinone; Phenothiazines; Purinones; Pyridones | 1997 |
Evidence that activation of protein kinase A inhibits human hair follicle growth and hair fibre production in organ culture and DNA synthesis in human and mouse hair follicle organ culture.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Female; Hair; Hair Follicle; Humans; Mice; Organ Culture Techniques; Phosphodiesterase Inhibitors; Vibrissae | 1997 |
Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone Marrow Cells; Bone Resorption; Bucladesine; Calcification, Physiologic; Carcinoma 256, Walker; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Mice; Milrinone; Osteoclasts; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyridones; Rats; Rats, Wistar; Xanthines | 1997 |
The role of cyclic AMP as a precursor of extracellular adenosine in the rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Animals; Colforsin; Cyclic AMP; Diterpenes; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine Monophosphate; Hippocampus; In Vitro Techniques; Male; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theophylline | 1997 |
Phosphodiesterases in the rat renal vasculature.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyclic AMP; Kidney; Male; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridones; Rats; Rats, Inbred WKY; Renal Circulation | 1997 |
Synergistic inhibition of vascular smooth muscle cell migration by phosphodiesterase 3 and phosphodiesterase 4 inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Animals; Aorta; Becaplermin; Cell Movement; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Humans; Kinetics; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Quinolones; Rats; Recombinant Proteins | 1998 |
Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Apoptosis; Cyclic AMP; Cyclic GMP; Female; HL-60 Cells; Humans; Milrinone; Phosphodiesterase Inhibitors; Pyridones; Pyrrolidinones; Rolipram | 1998 |
OPC-13013, a cyclic nucleotide phosphodiesterase type III, inhibitor, inhibits cell proliferation and transdifferentiation of cultured rat hepatic stellate cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Actins; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Cilostazol; Culture Media; Cyclic AMP; Desmin; Dose-Response Relationship, Drug; Isoenzymes; Liver; Male; Muscle, Smooth; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Tetrazoles; Xanthines | 1999 |
Induction of arginase II in human Caco-2 tumor cells by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Arginase; Caco-2 Cells; Colforsin; Cyclic AMP; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Isoquinolines; Kinetics; Okadaic Acid; Protein Biosynthesis; RNA, Messenger; Sulfonamides; Transcription, Genetic | 2000 |
Guanosine 3',5'-cyclic monophosphate mediated inhibition of cell death induced by nerve growth factor withdrawal and beta-amyloid: protective effects of propentofylline.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amyloid beta-Peptides; Animals; Apoptosis; Caspase 3; Caspases; Cyclic GMP; Dose-Response Relationship, Drug; Nerve Growth Factor; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; PC12 Cells; Penicillamine; Peptide Fragments; Phosphodiesterase Inhibitors; Rats; Rolipram; Xanthines | 2000 |
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Diazepam; DNA, Complementary; Humans; Immunoblotting; Mice; Milrinone; Molecular Sequence Data; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rolipram; Sequence Homology, Amino Acid | 2001 |
Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aorta; Cell Membrane; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytosol; Diabetes Mellitus, Type 2; Hydrolysis; Muscle, Smooth, Vascular; Obesity; Phenotype; Phosphodiesterase Inhibitors; Quinolones; Rats; Rats, Mutant Strains | 2002 |
Norepinephrine induces slow calcium signalling in murine brown preadipocytes through the beta-adrenoceptor/cAMP/protein kinase A pathway.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipocytes; Adipose Tissue, Brown; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Calcium Signaling; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Isoproterenol; Isoquinolines; Male; Mice; Mice, Inbred Strains; Norepinephrine; Phosphodiesterase Inhibitors; Quinolones; Receptors, Adrenergic, beta; Sulfonamides; Thapsigargin | 2003 |
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Membrane Proteins; Naproxen; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Purinones; Synovial Membrane; Time Factors | 2005 |
Characteristics of taurine release in slices from adult and developing mouse brain stem.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Alloxan; Animals; Brain Stem; Genistein; Ion Channels; Mice; Organ Culture Techniques; Potassium; Quinacrine; Riluzole; Taurine; Time Factors | 2006 |
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Aortic Valve Stenosis; Cardiomegaly; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Male; Myocardial Contraction; Myocytes, Cardiac; Organ Size; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Quinolones; Rats; Rats, Wistar; Second Messenger Systems | 2009 |
Acute hypoxia modifies cAMP levels induced by inhibitors of phosphodiesterase-4 in rat carotid bodies, carotid arteries and superior cervical ganglia.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Carotid Arteries; Carotid Body; Cell Hypoxia; Cyclic AMP; Female; In Vitro Techniques; Male; Oxygen; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Rolipram; Superior Cervical Ganglion | 2010 |
Regulation of 3',5'-cAMP in preglomerular smooth muscle and endothelial cells from genetically hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Endothelium, Vascular; Hypertension; Isoproterenol; Kidney; Male; Muscle, Smooth, Vascular; Phosphodiesterase 4 Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2010 |
Effects of chlorogenic acid on carbachol-induced contraction of mouse urinary bladder.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Carbachol; Chlorogenic Acid; Cyclic AMP; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice, Inbred Strains; Muscle Contraction; Muscle Relaxation; Phosphodiesterase 4 Inhibitors; Urinary Bladder | 2018 |