Page last updated: 2024-08-26

1-methyl-1,2,3,4-tetrahydroisoquinoline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1-methyl-1,2,3,4-tetrahydroisoquinoline has been researched along with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (50.00)18.2507
2000's3 (37.50)29.6817
2010's0 (0.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Mitsuo, Y; Mizuno, Y; Nagatsu, T; Suzuki, K; Yamauchi, Y1
Hirobe, M; Makino, Y; Ohta, S; Tasaki, Y1
Maruyama, W; Matsubara, K; Naoi, M; Ota, M; Takahashi, T1
Dostert, P; Nagatsu, T; Naoi, M; Niwa, T; Takeda, N; Tatematsu, A; Yoshida, M; Yoshizumi, H1
Absi, E; Ayala, A; Cano, J; CastaƱo, A; Machado, A; Parrado, J1
Abe, K; Ishiwata, K; Kawamura, K; Koyanagi, Y; Saitoh, T; Sano, T; Senda, M; Taguchi, K; Toda, J1
Kotake, Y; Ohta, S; Okuda, K1
Abe, K; Chiba, T; Ishikawa, R; Kambe, T; Munakata, H; Saitoh, T; Taguchi, K1

Other Studies

8 other study(ies) available for 1-methyl-1,2,3,4-tetrahydroisoquinoline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

ArticleYear
Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain.
    Journal of the neurological sciences, 1992, Volume: 109, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Dopamine Agents; Electron Transport; In Vitro Techniques; Isoquinolines; Mice; Mice, Inbred C57BL; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Tetrahydroisoquinolines

1992
1-Methyl-1,2,3,4-tetrahydroisoquinoline, decreasing in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse, prevents parkinsonism-like behavior abnormalities.
    Journal of neurochemistry, 1991, Volume: 57, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Brain Chemistry; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Motor Activity; Parkinson Disease; Rats; Tetrahydroisoquinolines; Time Factors

1991
Structural studies of condensation products of biogenic amines as inhibitors of tryptophan hydroxylase.
    Brain research, 1994, Aug-29, Volume: 655, Issue:1-2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Biogenic Amines; Brain; Dopamine; Isoquinolines; Kinetics; Male; Rats; Rats, Wistar; Structure-Activity Relationship; Tetrahydroisoquinolines; Tryptophan; Tryptophan Hydroxylase

1994
Presence of tetrahydroisoquinoline-related compounds, possible MPTP-like neurotoxins, in parkinsonian brain.
    Advances in neurology, 1993, Volume: 60

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Biotransformation; Culture Techniques; Dopamine; Frontal Lobe; Gas Chromatography-Mass Spectrometry; Humans; Isoquinolines; Neurotoxins; Parkinson Disease; Structure-Activity Relationship; Tetrahydroisoquinolines

1993
The endogenous amine 1-methyl-1,2,3,4- tetrahydroisoquinoline prevents the inhibition of complex I of the respiratory chain produced by MPP(+).
    Journal of neurochemistry, 2000, Volume: 75, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Brain; Corpus Striatum; Electron Transport Complex I; Isoquinolines; Male; Mitochondria; Mitochondria, Liver; NADH, NADPH Oxidoreductases; Oxygen Consumption; Rats; Rats, Wistar; Synaptosomes; Tetrahydroisoquinolines; Tyrosine 3-Monooxygenase

2000
Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism-preventing effect of 1-MeTIQ by in vivo measurement of pre-synaptic dopamine transporters and post-synaptic dopamine D(2) receptors in the mouse striatum.
    Journal of neurochemistry, 2001, Volume: 79, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Hypokinesia; Isoquinolines; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Parkinsonian Disorders; Radioligand Assay; Receptors, Dopamine D2; Stereoisomerism; Substantia Nigra; Synapses; Tetrahydroisoquinolines; Tyrosine 3-Monooxygenase; Up-Regulation

2001
Parkinsonism-preventing activity of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives in C57BL mouse in vivo.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:7

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Brain; Dopamine; Dopamine Antagonists; Mice; Mice, Inbred C57BL; Parkinsonian Disorders; Tetrahydroisoquinolines

2006
Preventative effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives (
    Canadian journal of physiology and pharmacology, 2022, Jul-01, Volume: 100, Issue:7

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Humans; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neuroprotective Agents; Parkinsonian Disorders; Tetrahydroisoquinolines

2022