Compounds > 1-isoamyl-3-isobutylxanthine
Page last updated: 2024-09-04

1-isoamyl-3-isobutylxanthine and theophylline

1-isoamyl-3-isobutylxanthine has been researched along with theophylline in 6 studies

Compound Research Comparison

Studies
(1-isoamyl-3-isobutylxanthine)		Trials
(1-isoamyl-3-isobutylxanthine)		Recent Studies (post-2010)
(1-isoamyl-3-isobutylxanthine)		Studies
(theophylline)		Trials
(theophylline)		Recent Studies (post-2010) (theophylline)
80020,0761,6121,383

Protein Interaction Comparison

ProteinTaxonomy1-isoamyl-3-isobutylxanthine (IC50)theophylline (IC50)
Adenosine receptor A1Bos taurus (cattle)2.43

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Daly, JW; Padgett, WL; Shamim, MT; Ukena, D1
Butts-Lamb, P; Daly, JW; Padgett, W; Shamim, MT; Waters, J1
Daly, JW; Manning, M; Müller, CE; Shi, D1
Jacobson, KA; Kim, HS; Kim, SA; Linden, J; Marshall, MA; Melman, N; Müller, CE1
Daly, JW; Smellie, FW; Wells, JN1
Bittar, EE; Bittar, R; Ueno, K1

Other Studies

6 other study(ies) available for 1-isoamyl-3-isobutylxanthine and theophylline

ArticleYear
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines

1989
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:4

    Topics: Adenosine; Animals; Cerebral Cortex; In Vitro Techniques; Rats; Receptors, Cell Surface; Receptors, Purinergic; Solubility; Structure-Activity Relationship

1985
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.
    Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22

    Topics: Animals; Brain; Radioligand Assay; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theophylline; Xanthines

1993
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
    Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11

    Topics: Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Ligands; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship; Xanthines

2002
1-Isoamyl-3-isobutylxanthine: a remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic AMP in brain slices.
    Life sciences, 1979, Nov-26, Volume: 25, Issue:22

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Brain; Cyclic AMP; Drug Synergism; Guinea Pigs; Histamine; In Vitro Techniques; Male; Norepinephrine; Phosphodiesterase Inhibitors; Theophylline; Xanthines

1979
Stimulation by octopamine of the sodium efflux in barnacle muscle fibres.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 79, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Chlorphenamidine; In Vitro Techniques; Kinetics; Muscles; Octopamine; Ouabain; Sodium; Theophylline; Thoracica

1984