Compounds > 1-isoamyl-3-isobutylxanthine
Page last updated: 2024-09-04

1-isoamyl-3-isobutylxanthine and 1-methyl-3-isobutylxanthine

1-isoamyl-3-isobutylxanthine has been researched along with 1-methyl-3-isobutylxanthine in 5 studies

Compound Research Comparison

Studies
(1-isoamyl-3-isobutylxanthine)		Trials
(1-isoamyl-3-isobutylxanthine)		Recent Studies (post-2010)
(1-isoamyl-3-isobutylxanthine)		Studies
(1-methyl-3-isobutylxanthine)		Trials
(1-methyl-3-isobutylxanthine)		Recent Studies (post-2010) (1-methyl-3-isobutylxanthine)
8005,1485279

Protein Interaction Comparison

ProteinTaxonomy1-isoamyl-3-isobutylxanthine (IC50)1-methyl-3-isobutylxanthine (IC50)
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AHomo sapiens (human)8.1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)31
Chain A, Phosphodiesterase 9AHomo sapiens (human)500
Chain A, Class I phosphodiesterase PDEB1Leishmania major580
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)698
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)40
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Phosphodiesterase Bos taurus (cattle)9.9
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)4
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)3.1667
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)9.9
Adenosine receptor A1Rattus norvegicus (Norway rat)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)9.9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BRattus norvegicus (Norway rat)0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.242
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)3.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CRattus norvegicus (Norway rat)0.1
Phosphodiesterase Rattus norvegicus (Norway rat)0.1

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ibay, AC; Martinson, EA; Schneller, SW; Wells, JN1
Daly, JW; Manning, M; Müller, CE; Shi, D1
Daly, JW; Smellie, FW; Wells, JN1
Honeyman, TW; Nemecek, GM1
Bittar, EE; Bittar, R; Ueno, K1

Other Studies

5 other study(ies) available for 1-isoamyl-3-isobutylxanthine and 1-methyl-3-isobutylxanthine

ArticleYear
Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogues of 3-isobutyl-1-methylxanthine.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Coronary Vessels; Structure-Activity Relationship; Theophylline

1986
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.
    Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22

    Topics: Animals; Brain; Radioligand Assay; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theophylline; Xanthines

1993
1-Isoamyl-3-isobutylxanthine: a remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic AMP in brain slices.
    Life sciences, 1979, Nov-26, Volume: 25, Issue:22

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Brain; Cyclic AMP; Drug Synergism; Guinea Pigs; Histamine; In Vitro Techniques; Male; Norepinephrine; Phosphodiesterase Inhibitors; Theophylline; Xanthines

1979
The role of cyclic nucleotide phosphodiesterase in the inhibition of cyclic AMP accumulation by carbachol and phosphatidate.
    Journal of cyclic nucleotide research, 1982, Volume: 8, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Carbachol; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Female; Fibroblasts; Humans; Phosphatidic Acids; Trifluoperazine

1982
Stimulation by octopamine of the sodium efflux in barnacle muscle fibres.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 79, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Chlorphenamidine; In Vitro Techniques; Kinetics; Muscles; Octopamine; Ouabain; Sodium; Theophylline; Thoracica

1984