Compounds > 1-hydroxymethylmidazolam
Page last updated: 2024-09-02

1-hydroxymethylmidazolam and nifedipine

1-hydroxymethylmidazolam has been researched along with nifedipine in 5 studies

Compound Research Comparison

Studies
(1-hydroxymethylmidazolam)		Trials
(1-hydroxymethylmidazolam)		Recent Studies (post-2010)
(1-hydroxymethylmidazolam)		Studies
(nifedipine)		Trials
(nifedipine)		Recent Studies (post-2010) (nifedipine)
163464916,0242,4961,505

Protein Interaction Comparison

ProteinTaxonomy1-hydroxymethylmidazolam (IC50)nifedipine (IC50)
perilipin-5Homo sapiens (human)7.133
perilipin-1Homo sapiens (human)9.619
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)8.376
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.0429
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.035
Cytochrome P450 1A2Homo sapiens (human)0.3
Cytochrome P450 3A4Homo sapiens (human)10
Adenosine receptor A3Homo sapiens (human)7.214
Cytochrome P450 2C9 Homo sapiens (human)3.06
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)10
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)7.214
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)0.0385
Potassium voltage-gated channel subfamily A member 5Homo sapiens (human)6.1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Rattus norvegicus (Norway rat)1.12
Adenosine receptor A1Homo sapiens (human)7.701
3-oxo-5-alpha-steroid 4-dehydrogenase 2Rattus norvegicus (Norway rat)1.12
C-C chemokine receptor type 2Homo sapiens (human)2.191
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)7.214
Cytochrome P450 2J2Homo sapiens (human)3.06
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.4733
Voltage-dependent L-type calcium channel subunit alpha-1CMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.035
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.0394
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.02
Potassium channel subfamily K member 2 Bos taurus (cattle)8.2
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)1.5
Voltage-dependent L-type calcium channel subunit alpha-1DMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1FMus musculus (house mouse)1.2

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Belas, F; Chaudhary, AK; Cvetkovic, M; Dempsey, PJ; Fromm, MF; Kim, RB; Leake, B; Roden, DM; Roden, MM; Wandel, C; Wilkinson, GR; Wood, AJ1
Katoh, M; Nakajima, M; Yamazaki, H; Yokoi, T1
Chougnet, A; Stoessel, C; Woggon, WD1
Ring, BJ; Wrighton, SA1
Kosugi, Y; Takahashi, J1

Other Studies

5 other study(ies) available for 1-hydroxymethylmidazolam and nifedipine

ArticleYear
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.
    Pharmaceutical research, 1999, Volume: 16, Issue:3

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Male; Mice; Oxidoreductases, N-Demethylating; Pharmacokinetics; Substrate Specificity

1999
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2001, Volume: 12, Issue:4

    Topics: Amiodarone; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Daunorubicin; Digoxin; Enzyme Inhibitors; GABA Modulators; Gonadal Steroid Hormones; Humans; LLC-PK1 Cells; Midazolam; Mixed Function Oxygenases; Nifedipine; Phthalazines; Swine; Testosterone

2001
Design and synthesis of a new fluorescent probe for cytochrome P450 3A4 (CYP 3A4).
    Bioorganic & medicinal chemistry letters, 2003, Nov-03, Volume: 13, Issue:21

    Topics: Binding Sites; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fluorescent Dyes; Kinetics; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Testosterone

2003
Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine.
    Pharmaceutical research, 1994, Volume: 11, Issue:6

    Topics: Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Midazolam; Nifedipine; Nizatidine

1994
Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:4

    Topics: Administration, Oral; Alkynes; Animals; Benzoxazines; Cyclopropanes; Cytochrome P-450 CYP3A; Drug Interactions; Haplorhini; Humans; Hydroxylation; Male; Microsomes, Liver; Midazolam; Nifedipine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Species Specificity; Substrate Specificity; Testosterone

2015