Compounds > 1-hydroxymethylmidazolam
Page last updated: 2024-09-02

1-hydroxymethylmidazolam and digoxin

1-hydroxymethylmidazolam has been researched along with digoxin in 3 studies

Compound Research Comparison

Studies
(1-hydroxymethylmidazolam)		Trials
(1-hydroxymethylmidazolam)		Recent Studies (post-2010)
(1-hydroxymethylmidazolam)		Studies
(digoxin)		Trials
(digoxin)		Recent Studies (post-2010) (digoxin)
163464911,4839581,289

Protein Interaction Comparison

ProteinTaxonomy1-hydroxymethylmidazolam (IC50)digoxin (IC50)
STAT3, partialHomo sapiens (human)1.862
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)0.32
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit alpha-3 Rattus norvegicus (Norway rat)0.22
Sodium/potassium-transporting ATPase subunit beta-1 Rattus norvegicus (Norway rat)0.0055
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 20.19
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-1Canis lupus familiaris (dog)0.5
Nuclear receptor ROR-gammaHomo sapiens (human)3.4798
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)0.335
Sodium/potassium-transporting ATPase subunit alpha-4Rattus norvegicus (Norway rat)0.0055
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)3.2359

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baba, K; Hamahata, Y; Hayashi, M; Iwanaga, K; Kakemi, M; Miyazaki, M; Shibano, M; Taniguchi, M1
Bi, H; Huang, L; Huang, M; Qin, X; Xiao, H; Xue, X; Zhong, G1
Alves, K; Chandorkar, G; Farmer, HF; Garg, V; Smith, F; van Heeswijk, RP1

Trials

1 trial(s) available for 1-hydroxymethylmidazolam and digoxin

ArticleYear
Effect of telaprevir on the pharmacokinetics of midazolam and digoxin.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:10

    Topics: Adolescent; Adult; Antiviral Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Oligopeptides; Protease Inhibitors; Young Adult

2012

Other Studies

2 other study(ies) available for 1-hydroxymethylmidazolam and digoxin

ArticleYear
Furanocoumarin derivatives in Kampo extract medicines inhibit cytochrome P450 3A4 and P-glycoprotein.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:8

    Topics: Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Furocoumarins; Humans; Medicine, Kampo; Midazolam; Quinidine

2010
Rapid and simultaneous measurement of midazolam, 1'-hydroxymidazolam and digoxin by liquid chromatography/tandem mass spectrometry: application to an in vivo study to simultaneously measure P-glycoprotein and cytochrome P450 3A activity.
    Journal of pharmaceutical and biomedical analysis, 2011, Apr-28, Volume: 55, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Calibration; Cardiotonic Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Drug Stability; Limit of Detection; Male; Midazolam; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2011