1-hydroxy-3-amino-2-pyrrolidone has been researched along with naloxone in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lehmann, H; Shepard, PD | 1 |
| DeCaprio, JL; Kosten, TA; Rosen, MI | 1 |
| Christensen, D; Guilbaud, G; Idänpään-Heikkilä, JJ; Kayser, V | 1 |
| Christensen, D; Guilbaud, G; Kayser, V | 1 |
| Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
6 other study(ies) available for 1-hydroxy-3-amino-2-pyrrolidone and naloxone
| Article | Year |
|---|---|
(+-)-1-hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor-mediated mechanism.
Topics: Animals; Dopamine; Drug Interactions; Electrophysiology; Injections, Intravenous; Male; Naloxone; Neurons; Pyrrolidinones; Rats; Rats, Inbred Strains; Stereoisomerism; Substantia Nigra | 1992 |
The severity of naloxone-precipitated opiate withdrawal is attenuated by felbamate, a possible glycine antagonist.
Topics: Animals; Anticonvulsants; Cycloserine; Excitatory Amino Acid Antagonists; Felbamate; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Phenylcarbamates; Propylene Glycols; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Substance Withdrawal Syndrome | 1995 |
The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy.
Topics: Analgesics, Opioid; Animals; Binding Sites; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Glycine; Hot Temperature; Male; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Nociceptors; Pain; Peripheral Nervous System Diseases; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Mechanical | 1998 |
The effect of the glycine/NMDA receptor antagonist, (+)-HA966, on morphine dependence in neuropathic rats.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy; Sodium Chloride; Substance Withdrawal Syndrome | 2000 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space | 2002 |
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Inflammation; Male; Naloxone; Narcotic Antagonists; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2003 |