1-hydroxy-3-amino-2-pyrrolidone has been researched along with morphine in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Besson, JM; Buritova, J; Chapman, V; Honoré, P | 1 |
| DeCaprio, JL; Kosten, TA; Rosen, MI | 1 |
| Christensen, D; Guilbaud, G; Idänpään-Heikkilä, JJ; Kayser, V | 1 |
| Balster, RL; Beardsley, PM; Bespalov, AY | 1 |
| Besson, JM; Catheline, G; Le Guen, S | 1 |
| Christensen, D; Gautron, M; Guilbaud, G; Kayser, V | 1 |
| Christensen, D; Guilbaud, G; Kayser, V | 2 |
| Allen, RM; Dykstra, LA; Granger, AL | 1 |
| Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C | 1 |
| Christensen, D; Kayser, V; Martinez, V | 1 |
| Carrigan, KA; Dykstra, LA; Fischer, BD | 1 |
| Adam, F; Bonnet, F; Le Bars, D | 1 |
| Adam, F; Dufour, E; Le Bars, D | 1 |
14 other study(ies) available for 1-hydroxy-3-amino-2-pyrrolidone and morphine
| Article | Year |
|---|---|
Concomitant administration of morphine and an N-methyl-D-aspartate receptor antagonist profoundly reduces inflammatory evoked spinal c-Fos expression.
Topics: Analgesics, Opioid; Animals; Body Temperature; Carrageenan; Gene Expression; Genes, fos; Inflammation; Male; Morphine; Pyrrolidinones; Rabbits; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Spinal Cord | 1996 |
The severity of naloxone-precipitated opiate withdrawal is attenuated by felbamate, a possible glycine antagonist.
Topics: Animals; Anticonvulsants; Cycloserine; Excitatory Amino Acid Antagonists; Felbamate; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Phenylcarbamates; Propylene Glycols; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Substance Withdrawal Syndrome | 1995 |
The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy.
Topics: Analgesics, Opioid; Animals; Binding Sites; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Glycine; Hot Temperature; Male; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Nociceptors; Pain; Peripheral Nervous System Diseases; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Mechanical | 1998 |
N-Methyl-D-aspartate receptor antagonists and the development of tolerance to the discriminative stimulus effects of morphine in rats.
Topics: Animals; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Morphine; Narcotics; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 1999 |
Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat.
Topics: Analgesics, Opioid; Animals; Binding Sites; Carrageenan; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Glycine; Immunohistochemistry; Isoquinolines; Male; Morphine; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Combined systemic administration of the glycine/NMDA receptor antagonist, (+)-HA966 and morphine attenuates pain-related behaviour in a rat model of trigeminal neuropathic pain.
Topics: Analgesics, Opioid; Animals; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Male; Morphine; Pain Measurement; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Trigeminal Neuralgia | 1999 |
Complete prevention but stimulus-dependent reversion of morphine tolerance by the glycine/NMDA receptor antagonist (+)-HA966 in neuropathic rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Tolerance; Excitatory Amino Acid Antagonists; Injections, Intravenous; Male; Morphine; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2000 |
The effect of the glycine/NMDA receptor antagonist, (+)-HA966, on morphine dependence in neuropathic rats.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy; Sodium Chloride; Substance Withdrawal Syndrome | 2000 |
Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys.
Topics: Analgesics, Opioid; Animals; Antitussive Agents; Benzamides; Conditioning, Operant; Dextromethorphan; Dizocilpine Maleate; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Piperazines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Saimiri | 2002 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space | 2002 |
The glycine/NMDA receptor antagonist (+)-HA966 enhances the peripheral effect of morphine in neuropathic rats.
Topics: Adjuvants, Pharmaceutic; Animals; Dose-Response Relationship, Drug; Drug Synergism; Male; Morphine; Pain Measurement; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sciatic Neuropathy | 2002 |
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidinones; Reaction Time; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2005 |
Tolerance to morphine analgesia: evidence for stimulus intensity as a key factor and complete reversal by a glycine site-specific NMDA antagonist.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Drug Tolerance; Electric Stimulation; Heart Rate; Injections, Intravenous; Male; Morphine; Nerve Fibers, Unmyelinated; Pain; Pain Threshold; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex; Stereoisomerism; Sural Nerve | 2006 |
The glycine site-specific NMDA antagonist (+)-HA966 enhances the effect of morphine and reverses morphine tolerance via a spinal mechanism.
Topics: Animals; Dose-Response Relationship, Radiation; Drug Tolerance; Electric Stimulation; Electromyography; Excitatory Amino Acid Antagonists; Male; Morphine; Morphine Dependence; Nerve Fibers, Unmyelinated; Pain Measurement; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Spinal Cord Injuries | 2008 |