1-hydroxy-3-amino-2-pyrrolidone has been researched along with kynurenic acid in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.25) | 18.7374 |
| 1990's | 25 (78.13) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lodge, D; Millar, JD; Pralong, E | 1 |
| Bradford, HF; Croucher, MJ | 1 |
| Kemp, JA; Priestley, T | 1 |
| Kloog, Y; Lamdani-Itkin, H; Sokolovsky, M | 1 |
| Ascher, P; Henderson, G; Johnson, JW | 1 |
| Paschetto, KA; Pullan, LM; Verticelli, AM | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Britt, M; Klika, AB; Meiners, BA; Powel, RJ; Pullan, LM; Salama, AI; Stumpo, RJ | 1 |
| Horne, AL; Kemp, JA; McKernan, RM; Priestley, T | 1 |
| Brugger, F; Fagg, GE; Nassenstein-Elton, D; Olpe, HR; Pozza, MF; Wicki, U | 1 |
| Colpaert, FC; Koek, W | 1 |
| Gale, K; Graham, J; Wardas, J | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Crawford, M; Roberts, PJ | 1 |
| Carobrez, AP; Graeff, FG; Guimarães, FS; Matheus, MG; Nogueira, RL | 1 |
| Danysz, W; Kretschmer, BD; Schmidt, WJ; Winterscheid, B | 1 |
| Witkin, JM | 1 |
| Löscher, W; Rundfeldt, C; Wlaź, P | 1 |
| Iversen, LL; Leeson, PD | 1 |
| Berger, P; Farrel, K; Sharp, F; Skolnick, P | 1 |
| Boje, KM; Skolnick, P; Wong, G | 1 |
| Cler, JA; Cordi, AA; Dappen, MS; Emmett, MR; Gray, NM; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Wood, PL | 1 |
| Aulakh, CS; Mazzola-Pomietto, P; Murphy, DL | 1 |
| Leslie, SW; Randall, PK; Robichon, R | 1 |
| Kawabe, A; Maruoka, Y; Nakamura, M; Ohno, Y; Ohtani, K; Sakamoto, H; Tamamura, C; Tanaka, H; Yasuda, H | 1 |
| Mancini, L; Mennini, T; Reggiani, A; Trist, D | 1 |
| VanDongen, AM; VanDongen, HM; Wood, MW | 1 |
| Capdevila, J; Skolnick, P; Trullas, R; Viu, E; Zapata, A | 1 |
| Mirshahi, T; Ronald, KM; Woodward, JJ | 1 |
| Smothers, CT; Woodward, JJ | 1 |
| De Castro Bastos, L; Martins, MA; Melo, NE; Tonussi, CR | 1 |
1 review(s) available for 1-hydroxy-3-amino-2-pyrrolidone and kynurenic acid
| Article | Year |
|---|---|
The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Binding Sites; Cognition; Glycine; Humans; Kynurenic Acid; Neuroprotective Agents; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1994 |
31 other study(ies) available for 1-hydroxy-3-amino-2-pyrrolidone and kynurenic acid
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glycine; Ibotenic Acid; Indoles; Kynurenic Acid; Mephenesin; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine | 1991 |
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1991 |
The glycine site of the N-methyl-D-aspartate receptor channel: differences between the binding of HA-966 and of 7-chlorokynurenic acid.
Topics: Animals; Binding Sites; Glycine; Ion Channels; Kynurenic Acid; Phencyclidine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1990 |
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor.
Topics: Action Potentials; Animals; Brain; Cells, Cultured; Cerebral Cortex; Cycloserine; Diencephalon; Glycine; Ion Channels; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1990 |
Agonist-like character of the (R)-enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966).
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; Male; Pyrrolidinones; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism; Synaptosomes | 1991 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
Stereoselective enhancement by (R)-HA-966 of the binding of [3H]CPP to the NMDA receptor complex.
Topics: Animals; In Vitro Techniques; Kynurenic Acid; Piperazines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism; Strychnine; Synaptic Membranes | 1990 |
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glycine; Hypoxia; Kinetics; Kynurenic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
Modulation of the NMDA receptor by D-serine in the cortex and the spinal cord, in vitro.
Topics: Animals; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Kynurenic Acid; Male; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Cord; Strychnine; Tetrodotoxin | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Different modes of action of 3-amino-1-hydroxy-2-pyrrolidone (HA-966) and 7-chlorokynurenic acid in the modulation of N-methyl-D-aspartate-sensitive glutamate receptors.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperazines; Protein Conformation; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
1-Hydroxy-3-aminopyrrolid-2-one (HA-966) and kynurenate antagonize N-methyl-D-aspartate induced enhancement of [3H]dopamine release from rat striatal slices.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Drug Antagonism; Kynurenic Acid; Male; N-Methylaspartate; Potassium; Pyrrolidinones; Rats; Rats, Inbred Strains | 1989 |
Anxiolytic effect of glycine antagonists microinjected into the dorsal periaqueductal grey.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conditioning, Operant; Electric Stimulation; Glycine; Kynurenic Acid; Male; Microinjections; Periaqueductal Gray; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Glycine site antagonists abolish dopamine D2 but not D1 receptor mediated catalepsy in rats.
Topics: Animals; Benzazepines; Catalepsy; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Kynurenic Acid; Male; Motor Activity; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists.
Topics: Amino Acids; Animals; Cocaine; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Male; Methamphetamine; Mice; Motor Activity; Pyrrolidinones; Quinoxalines | 1993 |
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Cycloserine; Differential Threshold; Epilepsy; Female; Glycine; Kindling, Neurologic; Kynurenic Acid; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1994 |
Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Dizocilpine Maleate; Gyrus Cinguli; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Strychnine | 1994 |
Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Molecular Sequence Data; Neurons; Neurotoxins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Time Factors | 1993 |
Indole-2-carboxylates, novel antagonists of the N-methyl-D-aspartate (NMDA)-associated glycine recognition sites: in vivo characterization.
Topics: Animals; Brain; Cerebellum; Cyclic GMP; Harmaline; Indoleacetic Acids; Kynurenic Acid; Ligands; Male; Mice; N-Methylaspartate; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1993 |
NMDA receptor antagonists block development of tolerance to m-CPP-induced increases in ACTH concentrations in rats.
Topics: Adrenocorticotropic Hormone; Animals; Dimethyl Sulfoxide; Dizocilpine Maleate; Drug Tolerance; Kynurenic Acid; Male; Phencyclidine; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists | 1996 |
A partial agonist model used in the allosteric modulation of the NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; Models, Biological; Protein Binding; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Selective depression of the spinal polysynaptic reflex by the NMDA receptor antagonists in an isolated spinal cord in vitro.
Topics: Animals; Depression, Chemical; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Serine; Spinal Cord; Spinal Nerve Roots; Strychnine; Valine | 1997 |
GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release.
Topics: Animals; Dopamine; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indoles; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
Topics: Animals; Binding Sites; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; Kynurenic Acid; Mice; Mutation; Oocytes; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1999 |
Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Inhibition, Psychological; Kynurenic Acid; Male; Memory Disorders; Mice; Muscarinic Antagonists; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Scopolamine | 2000 |
Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Humans; Kynurenic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 2001 |
Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.
Topics: Alanine; Animals; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Kynurenic Acid; Membrane Potentials; Mice; Mutation; Patch-Clamp Techniques; Pyrrolidinones; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Strychnine; Transfection | 2007 |
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Glycine; Kynurenic Acid; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Pyrrolidinones; Rats; Rats, Wistar | 2010 |