1-hydroxy-3-amino-2-pyrrolidone has been researched along with glycine in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (13.64) | 18.7374 |
| 1990's | 50 (75.76) | 18.2507 |
| 2000's | 6 (9.09) | 29.6817 |
| 2010's | 1 (1.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lodge, D; Millar, JD; Pralong, E | 1 |
| Briggs, RS; Porter, RH; Roberts, PJ | 1 |
| Bradford, HF; Croucher, MJ | 1 |
| Bristow, LJ; Hutson, PH; Thorn, L; Tricklebank, MD | 1 |
| Kemp, JA; Priestley, T | 2 |
| Kloog, Y; Lamdani-Itkin, H; Sokolovsky, M | 1 |
| Ascher, P; Henderson, G; Johnson, JW | 1 |
| Paschetto, KA; Pullan, LM; Verticelli, AM | 1 |
| Cler, JA; Emmett, MR; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 2 |
| Britt, M; Chapdelaine, MJ; Keith, RA; LaMonte, D; Mangano, TJ; Patel, J; Powel, RJ; Pullan, LM; Stumpo, RJ; Warwick, PJ | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Horne, AL; Kemp, JA; McKernan, RM; Priestley, T | 1 |
| Fedele, E; Fontana, G; Raiteri, M | 1 |
| Donald, AE; Foster, AC; Hutson, PH; Iversen, LL; Iversen, SD; Kemp, JA; Leeson, PD; Marshall, GR; Oles, RJ; Singh, L | 1 |
| Colpaert, FC; Koek, W | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Keith, RA; Mangano, TJ; Patel, J; Salama, AI | 1 |
| Baganoff, MP; Bolanowski, MA; Deppeler, CL; Lanthorn, TH; Watson, GB | 2 |
| Cler, JA; Compton, RP; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Sun, ET; Wood, PL | 1 |
| Gale, K; Graham, J; Wardas, J | 1 |
| Lanthorn, TH; Watson, GB | 1 |
| Foster, AC; Kemp, JA | 1 |
| Nishikawa, T; Shinohara, K; Takahashi, K; Yamazaki, K | 1 |
| Drejer, J; Honoré, T; Jensen, LH; Sheardown, MJ; Stidsen, CE | 1 |
| Keith, RA; Klika, AB; Mangano, TJ; Meiners, BA; Patel, J; Salama, AI; Stumpo, RJ | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Drejer, J; Honoré, T; Nielsen, EO; Sheardown, M | 1 |
| Fletcher, EJ; Lodge, D | 1 |
| Brotchie, JM; Carroll, CB; Holloway, V; Mitchell, IJ | 1 |
| Bigge, CF | 1 |
| Myhrer, T | 1 |
| Carobrez, AP; Graeff, FG; Guimarães, FS; Matheus, MG; Nogueira, RL | 1 |
| Jackson, PF; Pullan, LM; Rissolo, KC; Stauch Slusher, B | 1 |
| Aronstam, RS; Dennison, RL; Martin, DC | 1 |
| Hartmann, J; Ransmayr, G; Riederer, P | 1 |
| Löscher, W; Rundfeldt, C; Wlaź, P | 1 |
| Iversen, LL; Leeson, PD | 1 |
| Millan, MJ; Seguin, L | 2 |
| Baran, H; Hönack, D; Löscher, W; Rundfeldt, C; Wlaź, P | 1 |
| Bunney, BS; Goldstein, LE; Rasmusson, AM; Roth, RH | 1 |
| Jahr, CE; Lester, RA; Tong, G | 1 |
| Boje, KM; Skolnick, P; Wong, G | 1 |
| Löscher, W; Richter, A | 1 |
| Coyle, JT; Handen, JS; Montgomery, DT; Puttfarcken, PS; Werling, LL | 1 |
| Brave, S; French, D; Geter-Douglass, B; Witkin, JM | 1 |
| Morrow, BA; Roth, RH; Taylor, JR | 1 |
| Leslie, SW; Randall, PK; Robichon, R | 1 |
| Carlsson, ML; Nilsson, M | 1 |
| Mancini, L; Mennini, T; Reggiani, A; Trist, D | 1 |
| Christensen, D; Guilbaud, G; Idänpään-Heikkilä, JJ; Kayser, V | 1 |
| Carobrez, AP; Teixeira, KV | 1 |
| Besson, JM; Catheline, G; Le Guen, S | 1 |
| VanDongen, AM; VanDongen, HM; Wood, MW | 1 |
| Danysz, W; Karcz-Kubicha, M; Wedzony, K; Zajaczkowski, W | 1 |
| Mirshahi, T; Ronald, KM; Woodward, JJ | 1 |
| Chen, L; Muhlhauser, M; Yang, CR | 1 |
| Chatterjee, SS; Hilgert, M; Klein, J; Nawrath, H; Rupp, J; Weichel, O | 1 |
| Carnovali, F; Cervo, L; Cocco, A | 1 |
| Smothers, CT; Woodward, JJ | 1 |
| Aoki, Y; Ichinohe, A; Kamada, F; Kanno, J; Kojima-ishii, K; Komatsuzaki, S; Kure, S; Matsubara, Y; Mizoi, K; Nakahara, D; Narisawa, A; Oda, M; Shinka, T; Sugawara, T; Yokoyama, H | 1 |
| Davies, J; Watkins, JC | 1 |
| De Castro Bastos, L; Martins, MA; Melo, NE; Tonussi, CR | 1 |
2 review(s) available for 1-hydroxy-3-amino-2-pyrrolidone and glycine
| Article | Year |
|---|---|
Structural requirements for the development of potent N-methyl-D-aspartic acid (NMDA) receptor antagonists.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds; Drug Design; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channels; Models, Molecular; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1993 |
The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Binding Sites; Cognition; Glycine; Humans; Kynurenic Acid; Neuroprotective Agents; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1994 |
64 other study(ies) available for 1-hydroxy-3-amino-2-pyrrolidone and glycine
| Article | Year |
|---|---|
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glycine; Ibotenic Acid; Indoles; Kynurenic Acid; Mephenesin; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Modulation of [3H]3-((+-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid ([3H]CPP) binding by ligands acting at the glycine and the polyamine sites of the rat brain NMDA receptor complex.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding Sites; Brain; Glycine; In Vitro Techniques; Male; Piperazines; Polyamines; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Tritium | 1992 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine | 1991 |
R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine.
Topics: Amphetamine; Animals; Behavior, Animal; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Glycine; Locomotion; Male; Mice; Mice, Inbred Strains; Nucleus Accumbens; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1991 |
The glycine site of the N-methyl-D-aspartate receptor channel: differences between the binding of HA-966 and of 7-chlorokynurenic acid.
Topics: Animals; Binding Sites; Glycine; Ion Channels; Kynurenic Acid; Phencyclidine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1990 |
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor.
Topics: Action Potentials; Animals; Brain; Cells, Cultured; Cerebral Cortex; Cycloserine; Diencephalon; Glycine; Ion Channels; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1990 |
Agonist-like character of the (R)-enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966).
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; Male; Pyrrolidinones; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism; Synaptosomes | 1991 |
Glycine, glycinamide and D-serine act as positive modulators of signal transduction at the N-methyl-D-aspartate (NMDA) receptor in vivo: differential effects on mouse cerebellar cyclic guanosine monophosphate levels.
Topics: Animals; Cerebellum; Cerebral Ventricles; Cyclic GMP; Dose-Response Relationship, Drug; Glycine; Injections, Intraventricular; Isomerism; Male; Mice; Phencyclidine; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction | 1990 |
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.
Topics: Allosteric Site; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; Ileum; Isometric Contraction; Kinetics; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Norepinephrine; Pyrrolidinones; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1990 |
6,7-Dinitroquinoxaline-2,3-dione and 6-nitro,7-cyanoquinoxaline-2,3-dione antagonize responses mediated by N-methyl-D-aspartate and NMDA-associated glycine recognition sites in vivo: measurements of cerebellar cyclic-GMP.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebellum; Cyclic AMP; Glycine; Harmaline; Kinetics; Male; Mice; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Quisqualic Acid; Serine | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glycine; Hypoxia; Kinetics; Kynurenic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
Glycine stimulates [3H]noradrenaline release by activating a strychnine-sensitive receptor present in rat hippocampus.
Topics: Animals; Bicuculline; Calcium; Glycine; Hippocampus; In Vitro Techniques; Male; Norepinephrine; Potassium; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine; Synaptosomes; Tritium | 1990 |
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dopamine; Furans; Glycine; In Vitro Techniques; Isomerism; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Seizures; Serotonin | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Evidence for a functional coupling of the NMDA and glycine recognition sites in synaptic plasma membranes.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Cell Membrane; Glutamates; Glycine; In Vitro Techniques; Kinetics; Male; Phencyclidine; Piperazines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine; Synaptic Membranes | 1990 |
Glycine-evoked neurotransmitter release from rat hippocampal brain slices: evidence for the involvement of glutaminergic transmission.
Topics: Amino Acids; Animals; Calcium Channels; Glycine; Hippocampus; In Vitro Techniques; Magnesium; Male; Mollusk Venoms; Norepinephrine; omega-Conotoxin GVIA; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes.
Topics: Animals; Cycloserine; Glycine; Oocytes; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
Neuropharmacological characterization of 1-aminocyclopropane-1-carboxylate and 1-aminocyclobutane-1-carboxylate, ligands of the N-methyl-D-aspartate-associated glycine receptor.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Biological Availability; Brain Chemistry; Gas Chromatography-Mass Spectrometry; Glycine; Half-Life; Injections, Intravenous; Injections, Intraventricular; Mice; Pyrrolidinones; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Pharmacological characteristics of cyclic homologues of glycine at the N-methyl-D-aspartate receptor-associated glycine site.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Brain Chemistry; Cycloleucine; Glycine; Male; Pyrrolidinones; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus | 1990 |
HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site.
Topics: Animals; Cerebral Cortex; Electrophoresis; Glycine; In Vitro Techniques; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes | 1989 |
Glycine antagonist action of 1-aminocyclobutane-1-carboxylate (ACBC) in Xenopus oocytes injected with rat brain mRNA.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Brain; Drug Synergism; Female; Glycine; Oocytes; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1989 |
Ontogeny of strychnine-insensitive [3H]glycine binding sites in rat forebrain.
Topics: Animals; Brain; Gestational Age; Glycine; Male; Medial Forebrain Bundle; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Strychnine | 1989 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pregnancy; Pyrrolidinones; Quinoxalines; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1989 |
HA-966 acts at a modulatory glycine site to inhibit N-methyl-D-aspartate-evoked neurotransmitter release.
Topics: Animals; Aspartic Acid; Binding Sites; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Piperazines; Pyrrolidinones; Rats; Strychnine | 1989 |
Different modes of action of 3-amino-1-hydroxy-2-pyrrolidone (HA-966) and 7-chlorokynurenic acid in the modulation of N-methyl-D-aspartate-sensitive glutamate receptors.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperazines; Protein Conformation; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Chickens; Cortical Spreading Depression; Glycine; In Vitro Techniques; N-Methylaspartate; Neurons; Pyrrolidinones; Rats; Retina | 1989 |
Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Evoked Potentials; Glycine; In Vitro Techniques; N-Methylaspartate; Pyrrolidinones; Rats; Valine | 1988 |
Neurochemical and behavioural investigations of the NMDA receptor-associated glycine site in the rat striatum: functional implications for treatment of parkinsonian symptoms.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding, Competitive; Corpus Striatum; Dose-Response Relationship, Drug; Glycine; Locomotion; Male; Oxidopamine; Parkinson Disease; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Kinetic study of the interactions between the glutamate and glycine recognition sites on the N-methyl-D-aspartic acid receptor complex.
Topics: Animals; Binding Sites; Cells, Cultured; Glutamic Acid; Glycine; Kinetics; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Evidence for activation of NMDA receptors when memory function is reinstated in rats with glutamatergic temporal systems disrupted.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Entorhinal Cortex; Glutamic Acid; Glycine; Light; Male; Memory; Nerve Fibers; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Temporal Lobe | 1994 |
Anxiolytic effect of glycine antagonists microinjected into the dorsal periaqueductal grey.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conditioning, Operant; Electric Stimulation; Glycine; Kynurenic Acid; Male; Microinjections; Periaqueductal Gray; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Glycine; Male; Mice; Motor Activity; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Serine; Stimulation, Chemical | 1994 |
Volatile anesthetics inhibit NMDA-stimulated 45Ca uptake by rat brain microvesicles.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Calcium; Calcium Radioisotopes; Dizocilpine Maleate; Enflurane; Glycine; Halothane; Kinetics; Male; Microcirculation; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
The glycine binding site of the NMDA receptor: involvement in neurodegeneration and new approach for neuroprotection.
Topics: Autoradiography; Binding Sites; Binding, Competitive; Glycine; Hippocampus; Humans; In Vitro Techniques; Nerve Degeneration; Neuroprotective Agents; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1994 |
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Cycloserine; Differential Threshold; Epilepsy; Female; Glycine; Kindling, Neurologic; Kynurenic Acid; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1994 |
The glycine B receptor partial agonist, (+)-HA966, enhances induction of antinociception by RP 67580 and CP-99,994.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Indoles; Isoindoles; Male; Mice; Piperidines; Pyrrolidinones; Receptors, Glycine; Receptors, Tachykinin | 1994 |
Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cycloserine; Dizocilpine Maleate; Electric Stimulation; Epilepsy, Complex Partial; Female; Glycine; Kindling, Neurologic; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine | 1994 |
The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat.
Topics: Animals; Conditioning, Psychological; Corticosterone; Dopamine; Glycine; Male; Nucleus Accumbens; Prefrontal Cortex; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin; Stress, Psychological | 1994 |
Interactions between the glycine and glutamate binding sites of the NMDA receptor.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Neurons; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1993 |
Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Molecular Sequence Data; Neurons; Neurotoxins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Time Factors | 1993 |
The glycine/NMDA receptor ligand (+)-HA-966 but not D-cycloserine has potent antidystonic efficacy in a genetic animal model of dystonia.
Topics: Animals; Behavior, Animal; Cricetinae; Cycloserine; Disease Models, Animal; Dystonia; Female; Glycine; Male; Mesocricetus; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptic Transmission | 1993 |
N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices.
Topics: Animals; Calcium Channel Blockers; Dipeptides; Glycine; Hippocampus; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
(+)-HA 966, a partial agonist at the glycine site coupled to NMDA receptors, blocks formalin-induced pain in mice.
Topics: Animals; Formaldehyde; Glycine; Hindlimb; Male; Mice; Pain; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1993 |
Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor.
Topics: Amino Acids; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Ibogaine; Male; Mice; Piperidines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
Prior exposure to cocaine diminishes behavioral and biochemical responses to aversive conditioning: reversal by glycine/N-methyl-D-aspartate antagonist co-treatment.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain; Cocaine; Conditioning, Psychological; Dopamine; Electroshock; Glycine; Male; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin | 1995 |
A partial agonist model used in the allosteric modulation of the NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; Models, Biological; Protein Binding; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
The glycine antagonist (+)-HA-966 injected into the nucleus accumbens stimulates locomotion in mice. (Rapid communication).
Topics: Animals; Dose-Response Relationship, Drug; Glycine; Injections; Male; Mice; Mice, Inbred Strains; Motor Activity; Nucleus Accumbens; Pyrrolidinones; Stereoisomerism | 1997 |
GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release.
Topics: Animals; Dopamine; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indoles; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy.
Topics: Analgesics, Opioid; Animals; Binding Sites; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Glycine; Hot Temperature; Male; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Nociceptors; Pain; Peripheral Nervous System Diseases; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Mechanical | 1998 |
Effects of glycine or (+/-)-3-amino-1-hydroxy-2-pyrrolidone microinjections along the rostrocaudal axis of the dorsal periaqueductal gray matter on rats' performance in the elevated plus-maze task.
Topics: Animals; Anti-Anxiety Agents; Brain Mapping; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Male; Maze Learning; Microinjections; Periaqueductal Gray; Pyrrolidinones; Rats; Rats, Wistar | 1999 |
Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat.
Topics: Analgesics, Opioid; Animals; Binding Sites; Carrageenan; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Glycine; Immunohistochemistry; Isoquinolines; Male; Morphine; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
Topics: Animals; Binding Sites; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; Kynurenic Acid; Mice; Mutation; Oocytes; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1999 |
NMDA receptor antagonists acting at the glycineB site in rat models for antipsychotic-like activity.
Topics: 2-Amino-5-phosphonovalerate; Amphetamine; Animals; Antimetabolites; Antipsychotic Agents; Binding Sites; Cycloleucine; Cycloserine; Disease Models, Animal; Dopamine Agents; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; Hallucinogens; Locomotion; Male; Phencyclidine; Phthalazines; Protein Structure, Tertiary; Psychotic Disorders; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex, Startle | 1999 |
Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Humans; Kynurenic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 2001 |
Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo.
Topics: Amino Acid Transport Systems, Neutral; Animals; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; Glycine Plasma Membrane Transport Proteins; Iontophoresis; Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine | 2003 |
Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Calcium Isotopes; Cell Membrane; Chlorides; Choline; Cyclopentanes; Diterpenes; Diuretics; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Furans; Furosemide; Ginkgolides; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Potassium; Pyrrolidinones; Rats; Rats, Wistar; Synaptosomes | 2003 |
Effects on cocaine and food self-administration of (+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, in rats.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Agonists; Food; Glycine; Male; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Time Factors | 2004 |
Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.
Topics: Alanine; Animals; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Kynurenic Acid; Membrane Potentials; Mice; Mutation; Patch-Clamp Techniques; Pyrrolidinones; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Strychnine; Transfection | 2007 |
Model mice for mild-form glycine encephalopathy: behavioral and biochemical characterizations and efficacy of antagonists for the glycine binding site of N-methyl D-aspartate receptor.
Topics: Aggression; Amino Acid Oxidoreductases; Animals; Anxiety; Binding Sites; Brain Diseases, Metabolic; Carrier Proteins; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Multienzyme Complexes; Pyrrolidinones; Quinolones; Receptors, N-Methyl-D-Aspartate; Seizures; Transferases | 2008 |
Is 1-hydroxy-3-aminopyrrolidone-2 (HA-966) a selective excitatory amino-acid antagonist?
Topics: Acetylcholine; Animals; Cerebral Cortex; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Pyrrolidinones | 1972 |
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Glycine; Kynurenic Acid; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Pyrrolidinones; Rats; Rats, Wistar | 2010 |