1-hydroxy-3-amino-2-pyrrolidone has been researched along with glutamic acid in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 12 (63.16) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kemp, JA; Priestley, T | 2 |
| Britt, M; Chapdelaine, MJ; Keith, RA; LaMonte, D; Mangano, TJ; Patel, J; Powel, RJ; Pullan, LM; Stumpo, RJ; Warwick, PJ | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Humphrey, SJ; McCall, RB | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
| Bigge, CF | 1 |
| Myhrer, T | 1 |
| Witkin, JM | 1 |
| Starr, BS; Starr, MS | 1 |
| Jahr, CE; Lester, RA; Tong, G | 1 |
| Boje, KM; Skolnick, P; Wong, G | 1 |
| Barks, JD; Liu, XH; Silverstein, FS; Sun, R | 1 |
| Kakiuchi, T; Nishiyama, S; Shizuno, H; Tsukada, H | 1 |
| Capdevila, J; Skolnick, P; Trullas, R; Viu, E; Zapata, A | 1 |
| Mirshahi, T; Ronald, KM; Woodward, JJ | 1 |
| Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C | 1 |
| Joyner, PW; McMillen, BA; Parmar, CA; Tyer, WE; Williams, HL | 1 |
| Davies, J; Watkins, JC | 1 |
1 review(s) available for 1-hydroxy-3-amino-2-pyrrolidone and glutamic acid
| Article | Year |
|---|---|
Structural requirements for the development of potent N-methyl-D-aspartic acid (NMDA) receptor antagonists.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds; Drug Design; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channels; Models, Molecular; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1993 |
18 other study(ies) available for 1-hydroxy-3-amino-2-pyrrolidone and glutamic acid
| Article | Year |
|---|---|
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1991 |
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.
Topics: Allosteric Site; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; Ileum; Isometric Contraction; Kinetics; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Norepinephrine; Pyrrolidinones; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1990 |
Different modes of action of 3-amino-1-hydroxy-2-pyrrolidone (HA-966) and 7-chlorokynurenic acid in the modulation of N-methyl-D-aspartate-sensitive glutamate receptors.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperazines; Protein Conformation; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Evidence that L-glutamic acid mediates baroreceptor function in the cat.
Topics: Afferent Pathways; Animals; Brain Stem; Cats; Electrophysiology; Glutamates; Glutamic Acid; Neurotransmitter Agents; Phenylephrine; Pressoreceptors; Pyrrolidinones; Vagus Nerve | 1984 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Kinetic study of the interactions between the glutamate and glycine recognition sites on the N-methyl-D-aspartic acid receptor complex.
Topics: Animals; Binding Sites; Cells, Cultured; Glutamic Acid; Glycine; Kinetics; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Evidence for activation of NMDA receptors when memory function is reinstated in rats with glutamatergic temporal systems disrupted.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Entorhinal Cortex; Glutamic Acid; Glycine; Light; Male; Memory; Nerve Fibers; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Temporal Lobe | 1994 |
Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists.
Topics: Amino Acids; Animals; Cocaine; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Male; Methamphetamine; Mice; Motor Activity; Pyrrolidinones; Quinoxalines | 1993 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Pilocarpine; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Interactions between the glycine and glutamate binding sites of the NMDA receptor.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Neurons; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1993 |
Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Molecular Sequence Data; Neurons; Neurotoxins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Time Factors | 1993 |
gp120, a human immunodeficiency virus-1 coat protein, augments excitotoxic hippocampal injury in perinatal rats.
Topics: Animals; Animals, Newborn; Autoradiography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; HIV Envelope Protein gp120; Injections; Male; N-Methylaspartate; Neurotoxins; Piperazines; Pyrrolidinones; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Interactions of cholinergic and glutamatergic neuronal systems in the functional activation of cerebral blood flow response: a PET study in unanesthetized monkeys.
Topics: Animals; Brain; Cerebrovascular Circulation; Choline; Cycloserine; Glucose; Glutamic Acid; Macaca mulatta; Male; Neurons; Physical Stimulation; Physostigmine; Pyrrolidinones; Scopolamine; Somatosensory Cortex; Tomography, Emission-Computed | 1998 |
Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Inhibition, Psychological; Kynurenic Acid; Male; Memory Disorders; Mice; Muscarinic Antagonists; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Scopolamine | 2000 |
Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Humans; Kynurenic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 2001 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space | 2002 |
Effects of NMDA glutamate receptor antagonist drugs on the volitional consumption of ethanol by a genetic drinking rat.
Topics: Alcohol Drinking; Alcohol-Induced Disorders, Nervous System; Alcoholism; Amino Acids, Cyclic; Animals; Brain; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Female; Genetic Predisposition to Disease; Glutamic Acid; Isoquinolines; Male; Motor Activity; Pyrrolidinones; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Volition | 2004 |
Is 1-hydroxy-3-aminopyrrolidone-2 (HA-966) a selective excitatory amino-acid antagonist?
Topics: Acetylcholine; Animals; Cerebral Cortex; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Pyrrolidinones | 1972 |