Compounds > 1-hydroxy-2-dodecyl-4(1h)quinolone

1-hydroxy-2-dodecyl-4(1h)quinolone and diphenyliodonium

1-hydroxy-2-dodecyl-4(1h)quinolone has been researched along with diphenyliodonium* in 1 studies

Other Studies

1 other study(ies) available for 1-hydroxy-2-dodecyl-4(1h)quinolone and diphenyliodonium

Article	Year
Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3 Plasmodium falciparum NDH2 (pfNDH2) is a non-proton pumping, rotenone-insensitive alternative enzyme to the multi-subunit NADH:ubiquinone oxidoreductases (Complex I) of many other eukaryotes. Recombinantly expressed pfNDH2 prefers coenzyme CoQ(0) as an acceptor substrate, and can also use the artificial electron acceptors, menadione and dichlorophenol-indophenol (DCIP). Previously characterized NDH2 inhibitors, dibenziodolium chloride (DPI), diphenyliodonium chloride (IDP), and 1-hydroxy-2-dodecyl-4(1H)quinolone (HDQ) do not inhibit pfNDH2 activity. Here, we provide evidence that HDQ likely targets another P. falciparum mitochondrial enzyme, dihydroorotate dehydrogenase (pfDHOD), which is essential for de novo pyrimidine biosynthesis. Topics: Animals; Biphenyl Compounds; Chemistry, Pharmaceutical; Dihydroorotate Dehydrogenase; Drug Design; Electron Transport; Electrons; Enzyme Inhibitors; Indophenol; Models, Chemical; NADH Dehydrogenase; Onium Compounds; Oxidoreductases Acting on CH-CH Group Donors; Phenol; Plasmodium falciparum; Quinolones; Vitamin K 3	2009

Article

Year

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.

Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

Plasmodium falciparum NDH2 (pfNDH2) is a non-proton pumping, rotenone-insensitive alternative enzyme to the multi-subunit NADH:ubiquinone oxidoreductases (Complex I) of many other eukaryotes. Recombinantly expressed pfNDH2 prefers coenzyme CoQ(0) as an acceptor substrate, and can also use the artificial electron acceptors, menadione and dichlorophenol-indophenol (DCIP). Previously characterized NDH2 inhibitors, dibenziodolium chloride (DPI), diphenyliodonium chloride (IDP), and 1-hydroxy-2-dodecyl-4(1H)quinolone (HDQ) do not inhibit pfNDH2 activity. Here, we provide evidence that HDQ likely targets another P. falciparum mitochondrial enzyme, dihydroorotate dehydrogenase (pfDHOD), which is essential for de novo pyrimidine biosynthesis.

Topics: Animals; Biphenyl Compounds; Chemistry, Pharmaceutical; Dihydroorotate Dehydrogenase; Drug Design; Electron Transport; Electrons; Enzyme Inhibitors; Indophenol; Models, Chemical; NADH Dehydrogenase; Onium Compounds; Oxidoreductases Acting on CH-CH Group Donors; Phenol; Plasmodium falciparum; Quinolones; Vitamin K 3

2009